GIP receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8YW4

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41421-024-00700-0

PUBLICATION DATE

Sept. 18, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

67 interactions (Click to see)

LIGANDS

retatrutide - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

gastric inhibitory polypeptide (Mouse), gastric inhibitory polypeptide (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 E 253 - G.HN K 27 G.HN.51
Hydrophobic ICL3 R 328 - G.h4s6 Y 325 G.h4s6.20
Van-der-waals ICL3 R 328 - G.h4s6 Y 325 G.h4s6.20
Hydrophobic TM6 L 349 6x48 G.H5 Y 358 G.H5.23
Hydrophobic TM5 L 321 5x61 G.H5 L 361 G.H5.26
Hydrophobic TM5 K 324 5x64 G.H5 L 361 G.H5.26
Polar ICL3 R 328 - G.S6 C 326 G.S6.01
Van-der-waals ICL3 R 328 - G.S6 C 326 G.S6.01
Hydrophobic H8 N 396 8x47 G.H5 E 359 G.H5.24
Van-der-waals H8 N 396 8x47 G.H5 E 359 G.H5.24
Polar ICL2 L 247 - G.H5 R 347 G.H5.12
Van-der-waals ICL2 L 247 - G.H5 R 347 G.H5.12
Hydrophobic TM3 Y 240 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 Y 240 3x53 G.H5 Y 358 G.H5.23
Polar TM2 R 169 2x46 G.H5 Q 357 G.H5.22
Hydrophobic TM2 R 169 2x46 G.H5 Q 357 G.H5.22
Van-der-waals TM2 R 169 2x46 G.H5 Q 357 G.H5.22
Hydrophobic TM6 L 346 6x45 G.H5 L 360 G.H5.25
Polar TM3 L 244 3x57 G.H5 H 354 G.H5.19
Hydrophobic TM3 L 244 3x57 G.H5 H 354 G.H5.19
Van-der-waals TM3 L 244 3x57 G.H5 H 354 G.H5.19
Hydrophobic ICL2 V 248 - G.H5 R 347 G.H5.12
Van-der-waals ICL2 V 248 - G.H5 R 347 G.H5.12
Hydrophobic TM5 I 320 5x60 G.H5 L 355 G.H5.20
Polar TM6 R 338 6x37 G.H5 L 360 G.H5.25
Hydrophobic TM6 R 338 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 R 338 6x37 G.H5 L 360 G.H5.25
Hydrophobic TM3 L 241 3x54 G.H5 L 360 G.H5.25
Polar TM5 K 324 5x64 G.H5 R 352 G.H5.17
Hydrophobic TM5 K 324 5x64 G.H5 R 352 G.H5.17
Van-der-waals TM5 K 324 5x64 G.H5 R 352 G.H5.17
Polar TM3 E 237 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 L 244 3x57 G.H5 Y 358 G.H5.23
Hydrophobic TM5 K 324 5x64 G.H5 L 355 G.H5.20
Van-der-waals TM5 K 324 5x64 G.H5 L 355 G.H5.20
Polar H8 K 397 8x48 G.H5 E 359 G.H5.24
Hydrophobic H8 K 397 8x48 G.H5 E 359 G.H5.24
Van-der-waals H8 K 397 8x48 G.H5 E 359 G.H5.24
Hydrophobic TM3 L 241 3x54 G.H5 Y 358 G.H5.23
Van-der-waals TM3 L 241 3x54 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 S 251 - G.hns1 A 32 G.hns1.03
Polar TM3 L 245 3x58 G.H5 R 347 G.H5.12
Van-der-waals TM3 L 245 3x58 G.H5 R 347 G.H5.12
Polar ICL2 E 253 - G.HN Q 28 G.HN.52
Van-der-waals ICL2 E 253 - G.HN Q 28 G.HN.52
Hydrophobic TM5 L 321 5x61 G.H5 L 360 G.H5.25
Van-der-waals TM5 L 321 5x61 G.H5 L 360 G.H5.25
Hydrophobic TM6 F 345 6x44 G.H5 E 359 G.H5.24
Hydrophobic ICL2 S 251 - G.hns1 R 31 G.hns1.02
Polar TM3 L 245 3x58 G.H5 Q 351 G.H5.16
Hydrophobic TM3 L 245 3x58 G.H5 Q 351 G.H5.16
Van-der-waals TM3 L 245 3x58 G.H5 Q 351 G.H5.16
Ionic TM5 K 324 5x64 G.H5 D 348 G.H5.13
Polar TM5 K 324 5x64 G.H5 D 348 G.H5.13
Hydrophobic TM5 K 324 5x64 G.H5 D 348 G.H5.13
Polar TM6 S 342 6x41 G.H5 L 360 G.H5.25
Polar TM5 K 324 5x64 G.H5 Q 351 G.H5.16
Hydrophobic TM5 K 324 5x64 G.H5 Q 351 G.H5.16
Van-der-waals TM5 K 324 5x64 G.H5 Q 351 G.H5.16
Hydrophobic TM6 F 345 6x44 G.H5 L 360 G.H5.25
Hydrophobic ICL3 R 328 - G.H5 R 352 G.H5.17
Aromatic TM2 R 169 2x46 G.H5 Y 358 G.H5.23
Hydrophobic TM2 R 169 2x46 G.H5 Y 358 G.H5.23
Van-der-waals TM2 R 169 2x46 G.H5 Y 358 G.H5.23
Hydrophobic TM3 L 245 3x58 G.H5 H 354 G.H5.19
Van-der-waals TM3 L 245 3x58 G.H5 H 354 G.H5.19
Polar TM3 V 246 3x59 G.H5 R 347 G.H5.12
Hydrophobic TM5 L 321 5x61 G.H5 L 355 G.H5.20
Polar TM6 R 338 6x37 G.H5 E 359 G.H5.24
Van-der-waals TM6 R 338 6x37 G.H5 E 359 G.H5.24
Hydrophobic TM5 L 325 5x65 G.H5 L 361 G.H5.26
Van-der-waals TM5 L 325 5x65 G.H5 L 361 G.H5.26
Hydrophobic ICL2 V 248 - G.S3 V 194 G.S3.01
Van-der-waals ICL2 V 248 - G.S3 V 194 G.S3.01
Hydrophobic ICL2 V 248 - G.H5 F 343 G.H5.08
Hydrophobic ICL3 R 328 - G.S6 Y 327 G.S6.02
Van-der-waals ICL3 R 328 - G.S6 Y 327 G.S6.02
Polar TM6 R 338 6x37 G.H5 L 361 G.H5.26
Hydrophobic TM6 R 338 6x37 G.H5 L 361 G.H5.26
Hydrophobic ICL2 G 249 - G.S3 V 194 G.S3.01
Hydrophobic TM3 L 245 3x58 G.H5 L 355 G.H5.20
Van-der-waals TM3 L 245 3x58 G.H5 L 355 G.H5.20