PDB
9BUD
Resolution
2.5 Å
Released
April 23, 2025
Receptor
CT
Class
B1
Species
Homo sapiens
Ligand
cagrilintide
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
cagrilintide D77 N-term polar (charge-assisted hydrogen bond)
cagrilintide G78 N-term Van der Waals
cagrilintide W79 N-term hydrophobic
cagrilintide W79 N-term Van der Waals
cagrilintide F99 N-term Van der Waals
cagrilintide F99 N-term hydrophobic
cagrilintide P100 N-term hydrophobic
cagrilintide P100 N-term Van der Waals
cagrilintide D101 N-term polar (charge-assisted hydrogen bond)
cagrilintide F102 N-term hydrophobic
cagrilintide F102 N-term Van der Waals
cagrilintide W128 N-term Van der Waals
cagrilintide W128 N-term polar (hydrogen bond)
cagrilintide S129 N-term polar (hydrogen bond with backbone)
cagrilintide S129 N-term Van der Waals
cagrilintide Y131 N-term Van der Waals
cagrilintide Y131 N-term hydrophobic
cagrilintide T132 N-term Van der Waals
cagrilintide A136 N-term Van der Waals
cagrilintide F137 N-term Van der Waals
cagrilintide F137 N-term hydrophobic
cagrilintide A145 1.36x36 TM1 hydrophobic
cagrilintide A145 1.36x36 TM1 Van der Waals
cagrilintide Y146 1.37x37 TM1 Van der Waals
cagrilintide L148 1.39x39 TM1 hydrophobic
cagrilintide Y149 1.40x40 TM1 Van der Waals
cagrilintide Y149 1.40x40 TM1 hydrophobic
cagrilintide V206 ECL1 Van der Waals
cagrilintide R213 ECL1 polar (charge-assisted hydrogen bond)
cagrilintide M230 3.40x40 TM3 Van der Waals
cagrilintide Y234 3.44x44 TM3 hydrophobic
cagrilintide Y234 3.44x44 TM3 Van der Waals
cagrilintide L291 45.52x52 ECL2 polar (hydrogen bond with backbone)
cagrilintide L291 45.52x52 ECL2 Van der Waals
cagrilintide V293 ECL2 Van der Waals
cagrilintide V293 ECL2 polar (hydrogen bond with backbone)
cagrilintide E294 ECL2 Van der Waals
cagrilintide T295 ECL2 Van der Waals
cagrilintide T295 ECL2 polar (hydrogen bond with backbone)
cagrilintide H296 ECL2 Van der Waals
cagrilintide Y299 5.37x38 TM5 polar (hydrogen bond)
cagrilintide Y299 5.37x38 TM5 Van der Waals
cagrilintide H302 5.40x40 TM5 polar (hydrogen bond)
cagrilintide M306 5.44x44 TM5 Van der Waals
cagrilintide F356 6.53x53 TM6 hydrophobic
cagrilintide F356 6.53x53 TM6 Van der Waals
cagrilintide M376 7.42x41 TM7 Van der Waals
cagrilintide H377 7.43x42 TM7 Van der Waals
cagrilintide I380 7.46x45 TM7 Van der Waals
cagrilintide H381 7.47x46 TM7 Van der Waals

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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
Helix box plot — Download: PNG | SVG V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7

GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
1x36 1.40x40 Y149
TM3
3x36 3.40x40 M230
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x42 5.37x38 Y299
5x44 5.40x40 H302
5x48 5.44x44 M306
TM6
6x48 6.53x53 F356
TM7
7x37 7.42x41 M376
7x38 7.43x42 H377
7x41 7.46x45 I380
7x42 7.47x46 H381