PDB
9EPR
Resolution
4.9 Å
Released
Oct. 30, 2024
Receptor
Rhodopsin
Class
A
Species
Hasarius adansoni
Ligand
Function
all-trans-retinal
Agonist
Reference
10.1038/S41467-024-53208-2

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Ligand Amino Acid Generic Number Segment Interaction Type
all-trans-retinal M99 2.53x53 TM2 hydrophobic
all-trans-retinal Y126 3.28x28 TM3 Van der Waals
all-trans-retinal G134 3.36x36 TM3 Van der Waals
all-trans-retinal I202 45.52x52 ECL2 hydrophobic
all-trans-retinal L215 5.39x40 TM5 hydrophobic
all-trans-retinal Y218 5.42x43 TM5 hydrophobic
all-trans-retinal A219 5.43x44 TM5 hydrophobic
all-trans-retinal V222 5.46x461 TM5 Van der Waals
all-trans-retinal Y223 5.47x47 TM5 Van der Waals
all-trans-retinal W290 6.48x48 TM6 hydrophobic
all-trans-retinal Y293 6.51x51 TM6 hydrophobic
all-trans-retinal L294 6.52x52 TM6 Van der Waals
all-trans-retinal S297 6.55x55 TM6 Van der Waals
all-trans-retinal A317 7.39x38 TM7 Van der Waals
all-trans-retinal A320 7.42x41 TM7 Van der Waals
all-trans-retinal K321 7.43x42 TM7 covalent bond

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Snake plot — Download: PNG | SVG
ICL1 K N L R ICL1ECL1 T W V I ECL1ICL2 G M A G K P L ICL2ECL2 G W S R Y V P E G S M T S C T I D Y I D T ECL2ICL3 I K S L R S ICL3ECL3 D R T W L ECL3N-term M L P H A A K M A A R V A G D H D G R N I S I V D L L P E D M L P M I H E H W Y K F P P M N-termC-term P C L K C G S D S P K G D S A S T V A E S E K A G E C-term E T S M H Y I L G M L I I V I G I I S V S G N G V V M Y L M M T V T P G N F L V L N L A L S D F G M L F F M M P T M S I N C F A E G P F M C E L Y G M I G S L F G S A S I W S L V M I T L D R Y N V I V K T K V G A L L R M L F V W I W S L G W T I A P M Y A I N P M S Y L I A Y A I F V Y F V P L F I I I Y C Y A F I V M Q V A A H E K S L R E Q A K K M N N E D N K K A S A E F R L A K V A F M T I C C W F M A W T P Y L T L S F L G I F S T P M T S V W G A I F A K A S A C Y N P I V Y G I S H P K L H D Y R A A K F
Helix box plot — Download: PNG | SVG G N G S V S I I G I V I I L M G L I Y H 1 L N L A L S D F G M L F F M M P T M S I 2 M V L S W I S A S G F L S G I M G Y L E 3 A L L R M L F V W I W S L G W T I A P M 4 Y C Y I I I F L P V F Y V F I A Y A I L Y 5 F M T I C C W F M A W T P Y L T L S F L 6 I P N Y C A S A K A F I A G W V S T M 7

GPCRdb(A)
GPCRdb(A)
Rhodopsin
TM2
2x53 2.53x53 M99
TM3
3x28 3.28x28 Y126
3x36 3.36x36 G134
ECL2
45x52 45.52x52 I202
TM5
5x40 5.39x40 L215
5x43 5.42x43 Y218
5x44 5.43x44 A219
5x461 5.46x461 V222
5x47 5.47x47 Y223
TM6
6x48 6.48x48 W290
6x51 6.51x51 Y293
6x52 6.52x52 L294
6x55 6.55x55 S297
TM7
7x38 7.39x38 A317
7x41 7.42x41 A320
7x42 7.43x42 K321