Rhodopsin - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Hasarius adansoni

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

4.9 Å

REFERENCE

PUBLICATION DATE

Oct. 30, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Retinal (11-cis) - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
E12G.h4s6D09D13C23G24F26G.H5GproteinR5x73H5x68R3x50R6x32H8x47L5x72S7x56K8x49GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.h4s6G.H5GPCR segments:TM3TM5TM6TM7H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null3x503x545x685x695x725x735x796x326x337x568x478x488x49G.H5.26G.H5.25G.H5.24G.H5.23G.H5.20G.H5.16G.H5.13G.H5.12G.H5.09G.s6h5.04G.s6h5.02G.S6.05G.S6.02G.h4s6.12G.S3.01G.hns1.02Res. Pos.Rhodopsin (9EPR)- (9EPR)--------------RIHELRMRLSHPKRIHELRMRLSHPKMGLLDTDIYEFCTFCLA

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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