PDB
9L3Y
Resolution
3.6 Å
Released
March 12, 2025
Receptor
chemerin 2
Class
A
Species
Homo sapiens
Ligand
Chemerin
Function
Agonist
Reference
10.1093/PROCEL/PWAE073

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Ligand Amino Acid Generic Number Segment Interaction Type
Chemerin F12 N-term hydrophobic
Chemerin E13 N-term polar (charge-assisted hydrogen bond)
Chemerin N14 N-term Van der Waals
Chemerin Y15 N-term Van der Waals
Chemerin Y15 N-term polar (hydrogen bond)
Chemerin Y17 N-term polar (hydrogen bond with backbone)
Chemerin Y17 N-term Van der Waals
Chemerin L19 N-term Van der Waals
Chemerin L19 N-term polar (hydrogen bond with backbone)
Chemerin D20 N-term polar (charge-assisted hydrogen bond)
Chemerin Y21 N-term Van der Waals
Chemerin Y21 N-term polar (hydrogen bond with backbone)
Chemerin Y22 N-term hydrophobic
Chemerin Y22 N-term Van der Waals
Chemerin S23 N-term polar (hydrogen bond)
Chemerin S23 N-term polar (hydrogen bond with backbone)
Chemerin S23 N-term Van der Waals
Chemerin L24 N-term hydrophobic
Chemerin L24 N-term Van der Waals
Chemerin E25 N-term Van der Waals
Chemerin E25 N-term polar (hydrogen bond with backbone)
Chemerin S26 N-term Van der Waals
Chemerin D27 N-term Van der Waals
Chemerin D27 N-term polar (hydrogen bond with backbone)
Chemerin L28 N-term Van der Waals
Chemerin L28 N-term hydrophobic
Chemerin F86 2.53x53 TM2 aromatic (edge-to-face)
Chemerin F86 2.53x53 TM2 Van der Waals
Chemerin Y93 2.60x60 TM2 polar (hydrogen bond)
Chemerin Y93 2.60x60 TM2 Van der Waals
Chemerin Y96 2.63x63 TM2 Van der Waals
Chemerin Y96 2.63x63 TM2 polar (hydrogen bond)
Chemerin F101 ECL1 Van der Waals
Chemerin F101 ECL1 hydrophobic
Chemerin S114 3.29x29 TM3 polar (hydrogen bond)
Chemerin S114 3.29x29 TM3 polar (hydrogen bond with backbone)
Chemerin A117 3.32x32 TM3 Van der Waals
Chemerin A117 3.32x32 TM3 hydrophobic
Chemerin Q118 3.33x33 TM3 polar (hydrogen bond)
Chemerin Q118 3.33x33 TM3 polar (hydrogen bond)
Chemerin R176 ECL2 polar (charge-assisted hydrogen bond)
Chemerin V179 ECL2 hydrophobic
Chemerin V179 ECL2 Van der Waals
Chemerin L186 ECL2 Van der Waals
Chemerin L186 ECL2 hydrophobic
Chemerin Y188 45.51x51 ECL2 aromatic (face-to-face)
Chemerin Y188 45.51x51 ECL2 Van der Waals
Chemerin N189 45.52x52 ECL2 polar (hydrogen bond)
Chemerin N189 45.52x52 ECL2 polar (hydrogen bond with backbone)
Chemerin N189 45.52x52 ECL2 polar (hydrogen bond)
Chemerin Y262 6.51x51 TM6 Van der Waals
Chemerin Y262 6.51x51 TM6 hydrophobic
Chemerin E269 ECL3 polar (charge-assisted hydrogen bond)
Chemerin S276 ECL3 Van der Waals
Chemerin Y277 ECL3 Van der Waals
Chemerin Y277 ECL3 hydrophobic
Chemerin V281 7.30x29 TM7 Van der Waals
Chemerin M282 7.31x30 TM7 Van der Waals
Chemerin M282 7.31x30 TM7 hydrophobic
Chemerin I286 7.35x34 TM7 hydrophobic
Chemerin I286 7.35x34 TM7 Van der Waals
Chemerin F294 7.43x42 TM7 hydrophobic
Chemerin F294 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K K ICL1ECL1 F H W P F ECL1ICL2 P V L S H R H R ICL2ECL2 D T V E F N N H T L C Y N N F Q K H D P D ECL2ICL3 I L I ICL3ECL3 H N S Y S ECL3N-term M E D L E E T L F E E F E N Y S Y D L D Y Y S L E S D L E E K V Q L N-termC-term A E I L K Y T L W E V S C S G T V S E Q L R N S E T K N L C L L E T A Q C-term G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H T L K N S L I V I I F I W L L A S L I G G P A L Y F R L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F R S F Q A R S V
Helix box plot — Download: PNG | SVG A N G P I G L V F A L C Y L V L S V W H 1 L N L A I A D F I F L L F L P L Y I S Y 2 V T L F F V S A F M N L Q A T F S N A K 3 S L I V I I F I W L L A S L I G G P A L 4 Y C I S M T L L P F L Y G I I F K V W T L 5 L V V V V A F V V C W T P Y H L F S I W 6 I P N L C S N L F A L G T S L P I G A 7

GPCRdb(A)
GPCRdb(A)
chemerin receptor 2
TM2
2x53 2.53x53 F86
2x60 2.60x60 Y93
2x63 2.63x63 Y96
TM3
3x29 3.29x29 S114
3x32 3.32x32 A117
3x33 3.33x33 Q118
ECL2
45x51 45.51x51 Y188
45x52 45.52x52 N189
TM6
6x51 6.51x51 Y262
TM7
7x29 7.30x29 V281
7x30 7.31x30 M282
7x34 7.35x34 I286
7x42 7.43x42 F294