chemerin receptor 2 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9L3Y

RESOLUTION

3.6 Å

REFERENCE

10.1093/PROCEL/PWAE073

PUBLICATION DATE

March 12, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

107 interactions (Click to see)

LIGANDS

Chemerin - Agonist

PHYSIOLOGICAL LIGANDS

chemerin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 142 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 142 - G.H5 I 344 G.H5.16
Polar C-term K 310 - G.H5 K 349 G.H5.21
Hydrophobic C-term K 310 - G.H5 K 349 G.H5.21
Van-der-waals C-term K 310 - G.H5 K 349 G.H5.21
Hydrophobic TM3 H 138 3x53 G.H5 G 352 G.H5.24
Polar TM3 H 135 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 H 135 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 H 135 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 147 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 147 - G.hns1 R 32 G.hns1.03
Ionic ICL2 R 147 - G.s2s3 D 193 G.s2s3.02
Polar ICL1 K 69 - G.H5 D 350 G.H5.22
Hydrophobic TM6 R 243 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 243 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 240 6x29 G.H5 F 354 G.H5.26
Hydrophobic C-term F 311 - G.H5 L 353 G.H5.25
Van-der-waals C-term F 311 - G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 143 - G.H5 F 336 G.H5.08
Polar TM6 H 244 6x33 G.H5 F 354 G.H5.26
Aromatic TM6 H 244 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 H 244 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 H 244 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM2 T 72 2x39 G.H5 L 353 G.H5.25
Polar TM3 H 138 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 H 138 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 H 138 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 I 238 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 142 - G.H5 T 340 G.H5.12
Polar TM3 H 138 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 H 138 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 H 138 3x53 G.H5 N 347 G.H5.19
Polar TM2 T 70 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 70 2x37 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 70 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 72 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 139 3x54 G.H5 F 354 G.H5.26
Polar TM3 H 135 3x50 G.H5 F 354 G.H5.26
Hydrophobic TM3 H 135 3x50 G.H5 F 354 G.H5.26
Ionic TM5 R 236 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 236 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 236 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 236 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM2 F 76 2x43 G.H5 L 353 G.H5.25
Van-der-waals TM2 F 76 2x43 G.H5 L 353 G.H5.25
Hydrophobic C-term S 308 - G.H5 L 353 G.H5.25
Polar ICL2 H 146 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 L 139 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 139 3x54 G.H5 L 348 G.H5.20
Polar TM3 H 135 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 H 135 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 H 135 3x50 G.H5 G 352 G.H5.24
Polar ICL2 H 146 - G.hns1 R 32 G.hns1.03
Aromatic ICL2 H 146 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 146 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 146 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 143 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 H 138 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 H 138 3x53 G.H5 L 348 G.H5.20