PDB
9M1H
Resolution
2.6 Å
Released
April 30, 2025
Receptor
EP1
Class
A
Species
Homo sapiens
Ligand
PGE2
Function
Agonist
Reference
10.1073/PNAS.2423840122

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Ligand Amino Acid Generic Number Segment Interaction Type
PGE2 P39 1.39x39 TM1 polar (hydrogen bond with backbone)
PGE2 P39 1.39x39 TM1 Van der Waals
PGE2 S42 1.42x42 TM1 polar (hydrogen bond)
PGE2 M43 1.43x43 TM1 Van der Waals
PGE2 M43 1.43x43 TM1 hydrophobic
PGE2 G87 2.53x53 TM2 Van der Waals
PGE2 G87 2.53x53 TM2 polar (hydrogen bond with backbone)
PGE2 H88 2.54x54 TM2 polar (hydrogen bond)
PGE2 G92 2.58x58 TM2 Van der Waals
PGE2 V95 2.61x61 TM2 hydrophobic
PGE2 V95 2.61x61 TM2 Van der Waals
PGE2 Y99 2.65x65 TM2 Van der Waals
PGE2 Y99 2.65x65 TM2 polar (hydrogen bond)
PGE2 M117 3.32x32 TM3 Van der Waals
PGE2 M117 3.32x32 TM3 hydrophobic
PGE2 T186 ECL2 Van der Waals
PGE2 W187 ECL2 Van der Waals
PGE2 W310 6.48x48 TM6 Van der Waals
PGE2 W310 6.48x48 TM6 hydrophobic
PGE2 F334 7.36x35 TM7 hydrophobic
PGE2 F334 7.36x35 TM7 Van der Waals
PGE2 V337 7.39x38 TM7 hydrophobic
PGE2 V337 7.39x38 TM7 Van der Waals
PGE2 R338 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGE2 S341 7.43x42 TM7 polar (hydrogen bond)
PGE2 Q344 7.46x46 TM7 polar (hydrogen bond)
PGE2 Q344 7.46x46 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 G R L R ICL1ECL1 A G R A P A ECL1ICL2 P L L H A A R V ICL2ECL2 V G R Y E L Q Y P G T W C F I G L G P P G ECL2ICL3 P P P A S G P D S R R R W G A H G P R S A S A S S A S S I A S A S T F F G G S R S S G S A ICL3ECL3 W S S T S ECL3N-term M S P C G P L N L S L A G E A T T C A A P W V P N T S A V P P S G A N-termC-term G P A G L G L T P S A W E A S S L R S S R H S G L S H F C-term S P A L P I F S M T L G A V S N L L A L A L L A Q A A R R R S A A T F L L F V A S L L A T D L A G H V I P G A L V L R L Y T G G A C H F L G G C M V F F G L C P L L L G C G M A V E R C V G V T R S V A R A R L A L A A V A A V A L A V A L L P L A R G W R Q A L L A G L F A S L G L V A L L A A L V C N T L S G L A L L R A R W R R R S R R R R A R A H D V E M V G Q L V G I M V V S C I C W S P M L V L V A L A V G G L Q R P L F L A V R L A S W N Q I L D P W V Y I L L R Q A L L R R A G V L R Q L L P P A K G
Helix box plot — Download: PNG | SVG L N S V A G L T M S F I P L A P S 1 A S L L A T D L A G H V I P G A L V L R 2 G C G L L L P C L G F F V M C G G L F H 3 A R L A L A A V A A V A L A V A L L P L 4 L T N C V L A A L L A V L G L S A F L G 5 V G I M V V S C I C W S P M L V L V A L 6 W P D L I Q N W S A L R V A L F L P R 7

GPCRdb(A)
GPCRdb(A)
EP1 receptor
TM1
1x39 1.39x39 P39
1x42 1.42x42 S42
1x43 1.43x43 M43
TM2
2x53 2.53x53 G87
2x54 2.54x54 H88
2x58 2.58x58 G92
2x61 2.61x61 V95
2x65 2.65x65 Y99
TM3
3x32 3.32x32 M117
TM6
6x48 6.48x48 W310
TM7
7x35 7.36x35 F334
7x38 7.39x38 V337
7x39 7.40x39 R338
7x42 7.43x42 S341
7x46 7.46x46 Q344