EP1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9M1H

RESOLUTION

2.6 Å

REFERENCE

10.1073/PNAS.2423840122

PUBLICATION DATE

April 30, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

51 interactions (Click to see)

LIGANDS

PGE2 - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

PGF2α, PGE1, PGE2, PGD2, PGI2, thromboxane A2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL4 R 355 - G.H5 L 360 G.H5.25
Hydrophobic TM6 H 291 6x29 G.H5 V 361 G.H5.26
Van-der-waals TM6 H 291 6x29 G.H5 V 361 G.H5.26
Hydrophobic TM2 S 69 2x35 G.H5 E 357 G.H5.22
Van-der-waals TM2 S 69 2x35 G.H5 E 357 G.H5.22
Hydrophobic ICL2 L 143 34x51 G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 143 34x51 G.H5 F 343 G.H5.08
Hydrophobic TM2 F 73 2x39 G.H5 L 360 G.H5.25
Polar TM1 R 63 1x63 G.H5 V 361 G.H5.26
Hydrophobic TM1 R 63 1x63 G.H5 V 361 G.H5.26
Hydrophobic ICL2 P 142 34x50 G.H5 K 347 G.H5.12
Polar ICL2 H 145 34x53 G.H5 Y 358 G.H5.23
Polar TM3 R 135 3x50 G.H5 Y 358 G.H5.23
Aromatic TM3 R 135 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 135 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 142 34x50 G.H5 L 351 G.H5.16
Hydrophobic TM6 E 294 6x32 G.H5 N 359 G.H5.24
Polar TM3 E 134 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 E 134 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 E 134 3x49 G.H5 Y 358 G.H5.23
Polar TM6 H 291 6x29 G.H5 N 359 G.H5.24
Van-der-waals TM6 H 291 6x29 G.H5 N 359 G.H5.24
Hydrophobic TM2 R 68 2x34 G.HN R 31 G.HN.49
Hydrophobic TM3 V 139 3x54 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 143 34x51 G.S1 L 34 G.S1.02
Hydrophobic TM6 D 292 6x30 G.H5 L 355 G.H5.20
Van-der-waals TM6 D 292 6x30 G.H5 L 355 G.H5.20
Hydrophobic TM2 F 73 2x39 G.H5 Y 358 G.H5.23
Polar ICL2 A 147 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 147 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 147 34x55 G.hns1 R 32 G.hns1.03
Polar TM2 A 70 2x36 G.H5 E 357 G.H5.22
Hydrophobic TM2 A 70 2x36 G.H5 E 357 G.H5.22
Van-der-waals TM2 A 70 2x36 G.H5 E 357 G.H5.22
Hydrophobic ICL2 A 146 34x54 G.H5 I 350 G.H5.15
Hydrophobic TM6 M 295 6x33 G.H5 Y 358 G.H5.23
Van-der-waals TM6 M 295 6x33 G.H5 Y 358 G.H5.23
Polar TM3 G 138 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 G 138 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 G 138 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM6 R 287 6x25 G.h4s6 D 321 G.h4s6.10
Aromatic TM6 H 291 6x29 G.H5 R 356 G.H5.21
Hydrophobic TM6 H 291 6x29 G.H5 R 356 G.H5.21
Hydrophobic ICL2 L 143 34x51 G.H5 I 350 G.H5.15
Hydrophobic ICL2 L 143 34x51 G.H5 C 346 G.H5.11
Polar TM2 S 69 2x35 G.HN R 31 G.HN.49
Van-der-waals TM2 S 69 2x35 G.HN R 31 G.HN.49
Polar TM1 R 63 1x63 G.H5 L 360 G.H5.25
Hydrophobic TM6 R 287 6x25 G.h4s6 G 322 G.h4s6.11
Van-der-waals TM6 R 287 6x25 G.h4s6 G 322 G.h4s6.11
Polar TM6 Q 298 6x36 G.H5 N 359 G.H5.24
Van-der-waals TM6 Q 298 6x36 G.H5 N 359 G.H5.24
Hydrophobic TM3 G 138 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 G 138 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM6 H 291 6x29 G.H5 L 355 G.H5.20
Hydrophobic TM6 M 295 6x33 G.H5 N 359 G.H5.24
Van-der-waals TM6 M 295 6x33 G.H5 N 359 G.H5.24
Hydrophobic ICL4 R 355 - G.H5 N 359 G.H5.24
Hydrophobic TM1 A 60 1x60 G.H5 L 360 G.H5.25
Hydrophobic TM7 I 352 7x54 G.H5 L 360 G.H5.25
Hydrophobic TM6 A 288 6x26 G.H5 Q 352 G.H5.17
Hydrophobic ICL2 L 143 34x51 G.H5 K 347 G.H5.12
Van-der-waals ICL2 L 143 34x51 G.H5 K 347 G.H5.12
Polar ICL2 H 145 34x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 H 145 34x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 P 142 34x50 G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 142 34x50 G.H5 I 350 G.H5.15
Hydrophobic TM1 L 64 1x64 G.H5 V 361 G.H5.26
Van-der-waals TM1 L 64 1x64 G.H5 V 361 G.H5.26
Hydrophobic TM3 V 139 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM1 L 64 1x64 G.H5 L 360 G.H5.25
Van-der-waals TM1 L 64 1x64 G.H5 L 360 G.H5.25