PDB
9ODL
Resolution
3.6 Å
Released
Jan. 7, 2026
Receptor
μ
Class
A
Species
Mus musculus
Ligand
Mitragynine pseudoindoxyl
Function
Agonist (partial)
Reference
10.1038/S41586-025-10056-4

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Ligand Amino Acid Generic Number Segment Interaction Type
Mitragynine pseudoindoxyl Q124 2.60x60 TM2 polar (hydrogen bond)
Mitragynine pseudoindoxyl D147 3.32x32 TM3 Van der Waals
Mitragynine pseudoindoxyl Y148 3.33x33 TM3 hydrophobic
Mitragynine pseudoindoxyl Y148 3.33x33 TM3 Van der Waals
Mitragynine pseudoindoxyl M151 3.36x36 TM3 hydrophobic
Mitragynine pseudoindoxyl M151 3.36x36 TM3 Van der Waals
Mitragynine pseudoindoxyl W293 6.48x48 TM6 Van der Waals
Mitragynine pseudoindoxyl I296 6.51x51 TM6 Van der Waals
Mitragynine pseudoindoxyl I296 6.51x51 TM6 hydrophobic
Mitragynine pseudoindoxyl H297 6.52x52 TM6 Van der Waals
Mitragynine pseudoindoxyl V300 6.55x55 TM6 hydrophobic
Mitragynine pseudoindoxyl V300 6.55x55 TM6 Van der Waals
Mitragynine pseudoindoxyl H319 7.36x35 TM7 Van der Waals
Mitragynine pseudoindoxyl I322 7.39x38 TM7 hydrophobic
Mitragynine pseudoindoxyl I322 7.39x38 TM7 Van der Waals

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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q124
TM3
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x35 7.36x35 H319
7x38 7.39x38 I322