μ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9ODL

RESOLUTION

3.6 Å

REFERENCE

10.1038/S41586-025-10056-4

PUBLICATION DATE

Jan. 7, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

29 interactions (Click to see)

LIGANDS

Mitragynine pseudoindoxyl - Agonist (partial)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 L 265 - G.hns1 A 31 G.hns1.02
Ionic TM6 R 273 6x28 G.h3s5 D 261 G.h3s5.02
Polar TM6 R 273 6x28 G.h3s5 D 261 G.h3s5.02
Polar ICL3 L 265 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL3 L 265 - G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL3 L 265 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL3 L 265 - G.H5 N 347 G.H5.19
Van-der-waals ICL3 L 265 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 S 266 - G.S1 E 33 G.S1.01
Van-der-waals ICL3 S 266 - G.S1 E 33 G.S1.01
Polar ICL3 S 266 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 S 266 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 S 261 - G.H5 C 351 G.H5.23
Van-der-waals ICL3 S 261 - G.H5 C 351 G.H5.23