PDB
9W2I
Resolution
2.9 Å
Released
June 17, 2026
Receptor
NK2
Class
A
Species
Homo sapiens
Ligand
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 T24 N-term polar (hydrogen bond)
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 T24 N-term polar (hydrogen bond)
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 A25 N-term Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 A25 N-term polar (hydrogen bond with backbone)
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 F26 N-term Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 F26 N-term hydrophobic
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 N86 2.57x57 TM2 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 N90 2.61x61 TM2 polar (hydrogen bond)
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 N90 2.61x61 TM2 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 Y93 2.64x64 TM2 hydrophobic
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 Y93 2.64x64 TM2 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 A94 2.65x65 TM2 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 N97 ECL1 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 N110 3.29x29 TM3 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 I114 3.33x33 TM3 hydrophobic
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 I114 3.33x33 TM3 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 Q176 ECL2 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 A178 ECL2 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 K180 ECL2 polar (charge-assisted hydrogen bond)
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 C181 45.50x50 ECL2 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 V182 45.51x51 ECL2 hydrophobic
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 V182 45.51x51 ECL2 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 Y266 6.51x51 TM6 polar (hydrogen bond)
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 Y269 6.54x54 TM6 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 F270 6.55x55 TM6 hydrophobic
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 F270 6.55x55 TM6 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 Y280 ECL3 polar (hydrogen bond with backbone)
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 Y280 ECL3 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 C281 ECL3 polar (hydrogen bond)
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 C281 ECL3 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 I285 7.31x30 TM7 hydrophobic
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 I285 7.31x30 TM7 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 Q286 7.32x31 TM7 Van der Waals
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 Y289 7.35x34 TM7 polar (hydrogen bond)
Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 Y289 7.35x34 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R R M R ICL1ECL1 I W Y F ECL1ICL2 P F Q P R L ICL2ECL2 T V T M D Q G A T K C V V A W P E D ECL2ICL3 Q A H G ICL3ECL3 E D I Y C H ECL3N-term M G T C D I V T E A N I S S G P E S N T T G I T A F S M N-termC-term R C C P W V T P T K E D K L E L T P T T S L S T R V N R C H T K E T L F M A G D T A P S E A T S G E A G R P Q D G S G L W F G Y G L L A P T K T H V E I C-term P S W Q L A L W A T A Y L A L V L V A V T G N A I V I W I I L A H T V T N Y F I V N L A L A D L C M A A F N A A F N F V Y A S H N G R A F C Y F Q N L F P I T A M F V S I Y S M T A I A A D R Y M A I V H S A P S T K A V I A G I W L V A L A L A S P Q C F Y S S G G K T L L L Y H L V V I A L I Y F L P L A V M F V A Y S V I G L T L W R R A V P G H A N L R H L Q A M K K F V K T M V L V V L T F A I C W L P Y H L Y F I L G S F Q K F I Q Q V Y L A L F W L A M S S T M Y N P I I Y C C L N H R F R L F R S G A F
Helix box plot — Download: PNG | SVG A N G T V A V L V L A L Y A T A W L A L 1 V N L A L A D L C M A A F N A A F N F V 2 A T M S Y I S V F M A T I P F L N Q F Y 3 T K A V I A G I W L V A L A L A S P Q 4 Y A V F M V A L P L F Y I L A I V V L H Y 5 V L V V L T F A I C W L P Y H L Y F I L 6 I P N Y M T S S M A L W F L A L Y V Q 7

GPCRdb(A)
GPCRdb(A)
NK2 receptor
TM2
2x57 2.57x57 N86
2x61 2.61x61 N90
2x64 2.64x64 Y93
2x65 2.65x65 A94
TM3
3x29 3.29x29 N110
3x33 3.33x33 I114
ECL2
45x50 45.50x50 C181
45x51 45.51x51 V182
TM6
6x51 6.51x51 Y266
6x54 6.54x54 Y269
6x55 6.55x55 F270
TM7
7x30 7.31x30 I285
7x31 7.32x31 Q286
7x34 7.35x34 Y289