NK2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9W2I

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

June 17, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

67 interactions (Click to see)

LIGANDS

Peptide 336 (P336) spinning GLU-LYS-TYR-VAL-GLY-MLE-NLE-NH2 - Agonist

PHYSIOLOGICAL LIGANDS

neuropeptide K (Human), substance P (Human), neuropeptide γ (Human), neurokinin B (Human), neurokinin A (Human), hemokinin 1 (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 131 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 393 G.H5.25
Polar ICL2 R 142 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 142 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 142 - G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 135 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 139 - G.S3 V 217 G.S3.01
Hydrophobic TM7 L 310 7x56 G.H5 V 394 G.H5.26
Van-der-waals TM7 L 310 7x56 G.H5 V 394 G.H5.26
Hydrophobic TM3 I 135 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 135 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL3 G 231 - G.S6 P 361 G.S6.03
Van-der-waals ICL3 G 231 - G.S6 P 361 G.S6.03
Hydrophobic ICL2 F 139 - G.H5 C 379 G.H5.11
Van-der-waals ICL2 F 139 - G.H5 C 379 G.H5.11
Van-der-waals ICL3 G 231 - G.S6 C 359 G.S6.01
Hydrophobic ICL3 H 232 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 I 135 3x54 G.H5 L 384 G.H5.16
Polar TM3 D 130 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 130 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 130 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 139 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 138 - G.H5 K 380 G.H5.12
Aromatic ICL2 F 139 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 139 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 139 - G.H5 F 376 G.H5.08
Hydrophobic TM5 R 227 5x68 G.H5 L 384 G.H5.16
Hydrophobic TM2 T 68 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 68 2x39 G.H5 Y 391 G.H5.23
Polar ICL3 Q 233 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 Q 233 - G.H4 R 342 G.H4.12
Hydrophobic TM6 M 245 6x30 G.H5 L 388 G.H5.20
Van-der-waals TM6 M 245 6x30 G.H5 L 388 G.H5.20
Aromatic ICL3 H 232 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 H 232 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 H 232 - G.S6 Y 360 G.S6.02
Polar TM3 A 134 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 387 G.H5.19
Hydrophobic ICL2 F 139 - G.S3 F 219 G.S3.03
Polar H8 R 313 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 R 313 8x49 G.H5 R 389 G.H5.21
Hydrophobic ICL2 P 138 - G.H5 L 384 G.H5.16
Hydrophobic TM3 A 134 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 134 3x53 G.H5 Y 391 G.H5.23
Polar H8 N 311 8x47 G.H5 N 392 G.H5.24
Hydrophobic H8 N 311 8x47 G.H5 N 392 G.H5.24
Van-der-waals H8 N 311 8x47 G.H5 N 392 G.H5.24
Polar TM6 H 241 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 H 241 6x26 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 H 241 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 M 245 6x30 G.H5 Q 385 G.H5.17
Van-der-waals TM6 M 245 6x30 G.H5 Q 385 G.H5.17
Hydrophobic H8 N 311 8x47 G.H5 V 394 G.H5.26
Polar TM2 N 69 2x40 G.H5 N 392 G.H5.24
Van-der-waals ICL3 Q 233 - G.H4 D 343 G.H4.13
Polar TM2 T 68 2x39 G.H5 E 390 G.H5.22
Van-der-waals TM2 T 68 2x39 G.H5 E 390 G.H5.22
Polar H8 R 313 8x49 G.H5 N 392 G.H5.24
Hydrophobic H8 R 313 8x49 G.H5 N 392 G.H5.24
Van-der-waals H8 R 313 8x49 G.H5 N 392 G.H5.24
Hydrophobic ICL2 F 139 - G.H5 K 380 G.H5.12
Van-der-waals ICL2 F 139 - G.H5 K 380 G.H5.12
Hydrophobic ICL2 P 138 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 138 - G.H5 I 383 G.H5.15
Aromatic ICL2 F 139 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 139 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 139 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 P 141 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 F 248 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 F 248 6x33 G.H5 L 393 G.H5.25
Ionic TM5 R 227 5x68 G.H5 D 381 G.H5.13
Polar TM5 R 227 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 227 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 227 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 L 224 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL3 Q 233 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 Q 233 - G.H4 L 346 G.H4.16
Hydrophobic ICL3 H 232 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 H 232 - G.S6 C 359 G.S6.01
Hydrophobic TM5 L 224 5x65 G.H5 L 384 G.H5.16
Hydrophobic TM6 H 241 6x26 G.h4s6 G 355 G.h4s6.11