Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

1481 2066 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749 2066 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
589 2066 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
6908 2066 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
CHEMBL1513 2066 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
DB01029 2066 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
40466887 205875 66 None - 1 Human 5.4 pAC50 = 5.4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
5362124 205875 66 None - 1 Human 5.4 pAC50 = 5.4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
CHEMBL838 205875 66 None - 1 Human 5.4 pAC50 = 5.4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
1610 2347 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 2347 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 2347 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 2347 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 2347 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 2347 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
158781 44166 98 None -95499 3 Human 4.3 pAC50 = 4.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
CHEMBL1516 44166 98 None -95499 3 Human 4.3 pAC50 = 4.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
1610 2347 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 2347 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 2347 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 2347 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 2347 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 2347 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
1610 2347 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 2347 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 2347 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 2347 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 2347 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 2347 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
130881 2921 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
1985 2921 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
591 2921 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
CHEMBL1200692 2921 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
DB00275 2921 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
40466887 205875 66 None - 1 Human 5.1 pAC50 = 5.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
5362124 205875 66 None - 1 Human 5.1 pAC50 = 5.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
CHEMBL838 205875 66 None - 1 Human 5.1 pAC50 = 5.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
2541 786 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
587 786 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
6907 786 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1016 786 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB00796 786 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB13919 786 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
3033 30152 102 None -8709 4 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 295 4 2 2 4.4 O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
CHEMBL1034 30152 102 None -8709 4 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 295 4 2 2 4.4 O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
CHEMBL139 30152 102 None -8709 4 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 295 4 2 2 4.4 O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
2540 4401 111 None -1380 28 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 4401 111 None -1380 28 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
1481 2066 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749 2066 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
589 2066 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
6908 2066 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
CHEMBL1513 2066 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
DB01029 2066 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
44377942 57454 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 530 6 2 5 5.9 O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F 10.1021/jm1013693
CHEMBL165572 57454 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 530 6 2 5 5.9 O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F 10.1021/jm1013693
44355628 24906 0 None -5 2 Rat 6.0 pIC50 = 6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
CHEMBL134567 24906 0 None -5 2 Rat 6.0 pIC50 = 6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
10411653 24424 0 None -208 2 Rat 5.0 pIC50 = 5 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
CHEMBL134151 24424 0 None -208 2 Rat 5.0 pIC50 = 5 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
10410730 24618 0 None -6 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
CHEMBL134307 24618 0 None -6 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
10048220 26189 0 None -109 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL135704 26189 0 None -109 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10322995 115263 0 None -134 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
CHEMBL334832 115263 0 None -134 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
10003482 165743 0 None -158 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL424643 165743 0 None -158 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10364891 26245 0 None -33 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
CHEMBL135792 26245 0 None -33 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
192345 26236 6 None -12022 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL135775 26236 6 None -12022 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10393397 22799 0 None -6 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL132807 22799 0 None -6 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
10367704 22343 0 None -25 2 Rat 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL132408 22343 0 None -25 2 Rat 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10094520 24758 0 None -11 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
CHEMBL134433 24758 0 None -11 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
15698118 206143 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 537 10 2 6 5.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL86067 206143 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 537 10 2 6 5.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm1013693
44355660 21557 0 None -89 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL131676 21557 0 None -89 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
11743704 115498 0 None -3 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
CHEMBL335179 115498 0 None -3 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
10026268 116930 0 None -173 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
CHEMBL338505 116930 0 None -173 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
10322504 26383 0 None -19 2 Rat 5.8 pIC50 = 5.8 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135929 26383 0 None -19 2 Rat 5.8 pIC50 = 5.8 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10095493 26048 0 None -93 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
CHEMBL135521 26048 0 None -93 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
11754335 25303 0 None -186 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
CHEMBL134901 25303 0 None -186 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
1610 2347 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
3941 2347 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
3961 2347 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
590 2347 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
CHEMBL191 2347 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
DB00678 2347 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
44355662 26462 0 None -125 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL135999 26462 0 None -125 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
10411101 165665 0 None -676 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
CHEMBL424465 165665 0 None -676 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
19742811 57421 0 None 1 3 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL165354 57421 0 None 1 3 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
130762 98247 9 None 1 6 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm1013693
CHEMBL274447 98247 9 None 1 6 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm1013693
192567 116652 6 None -223 2 Rat 6.7 pIC50 = 6.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL337007 116652 6 None -223 2 Rat 6.7 pIC50 = 6.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
10366811 24826 0 None -31 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
CHEMBL134491 24826 0 None -31 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
11744592 115503 0 None -33 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
CHEMBL335228 115503 0 None -33 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
10409549 115978 0 None -104 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL335514 115978 0 None -104 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10027636 24594 0 None -70 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL134286 24594 0 None -70 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
71455883 83764 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1021/jm1013693
CHEMBL2205685 83764 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1021/jm1013693
10048602 26050 0 None -37 2 Rat 4.6 pIC50 = 4.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
CHEMBL135522 26050 0 None -37 2 Rat 4.6 pIC50 = 4.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
9914666 116670 0 None -3388 2 Rat 5.6 pIC50 = 5.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL337086 116670 0 None -3388 2 Rat 5.6 pIC50 = 5.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
9846535 57515 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 427 5 2 4 5.4 O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 10.1021/jm1013693
CHEMBL166143 57515 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 427 5 2 4 5.4 O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 10.1021/jm1013693
10326140 116651 0 None -2884 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL337006 116651 0 None -2884 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
10365283 25853 0 None -416 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135345 25853 0 None -416 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10393717 116099 0 None -524 2 Rat 6.4 pIC50 = 6.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL335722 116099 0 None -524 2 Rat 6.4 pIC50 = 6.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
10344571 116614 0 None -125 2 Rat 5.4 pIC50 = 5.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336773 116614 0 None -125 2 Rat 5.4 pIC50 = 5.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10027714 115437 0 None -398 2 Rat 5.3 pIC50 = 5.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL335066 115437 0 None -398 2 Rat 5.3 pIC50 = 5.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10004112 25530 0 None -93 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL135089 25530 0 None -93 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10344052 116607 0 None -107 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336738 116607 0 None -107 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10437543 26267 0 None -7 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL135819 26267 0 None -7 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
10414429 115997 0 None -363 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
CHEMBL335535 115997 0 None -363 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
10434876 116618 0 None -7 2 Rat 6.2 pIC50 = 6.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336808 116618 0 None -7 2 Rat 6.2 pIC50 = 6.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10026868 23859 0 None -331 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL133653 23859 0 None -331 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
10456041 25855 0 None -186 2 Rat 6.1 pIC50 = 6.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135346 25855 0 None -186 2 Rat 6.1 pIC50 = 6.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10095589 115519 0 None -851 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL335289 115519 0 None -851 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10345459 116770 0 None -43 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
CHEMBL337663 116770 0 None -43 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
10250898 118488 0 None -37 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
CHEMBL341407 118488 0 None -37 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
10071193 204324 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonism against A-2 induced contraction of aortic rings of rabbit.Antagonism against A-2 induced contraction of aortic rings of rabbit.
ChEMBL 427 7 1 4 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 10.1021/jm9508853
CHEMBL71485 204324 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonism against A-2 induced contraction of aortic rings of rabbit.Antagonism against A-2 induced contraction of aortic rings of rabbit.
ChEMBL 427 7 1 4 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 10.1021/jm9508853
6918 1028 35 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
9804984 1028 35 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
CHEMBL189568 1028 35 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
6918 1028 35 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
9804984 1028 35 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
CHEMBL189568 1028 35 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
6918 1028 35 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
9804984 1028 35 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
CHEMBL189568 1028 35 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
1610 2347 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2347 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2347 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2347 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2347 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2347 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
36736 3474 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
598 3474 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
6324663 3474 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
CHEMBL356431 3474 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
123805 417 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
46878481 417 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
5578 417 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
582 417 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
CHEMBL3545347 417 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
DB11720 417 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
8374 2922 42 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
9937291 2922 42 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
CHEMBL34124 2922 42 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
DB16266 2922 42 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
8374 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
8374 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
8374 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
9937291 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
9937291 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
9937291 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
CHEMBL34124 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
CHEMBL34124 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
CHEMBL34124 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
DB16266 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
DB16266 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
DB16266 2922 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
114899 3020 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
114899 3020 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
114899 3020 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
596 3020 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
596 3020 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
596 3020 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
CHEMBL1188080 3020 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
CHEMBL1188080 3020 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
CHEMBL1188080 3020 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
36736 3474 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
598 3474 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
6324663 3474 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
CHEMBL356431 3474 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
123794 893 46 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
3944 893 46 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
594 893 46 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
CHEMBL1885579 893 46 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
6894 418 0 None 2 3 Human 9.9 pIC50 = 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938
91691124 418 0 None 2 3 Human 9.9 pIC50 = 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

44348523 113179 0 None - 0 Rat 10.3 pIC50 = 10.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 113179 0 None - 0 Rat 10.3 pIC50 = 10.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
11930 1019 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
15780052 1019 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
CHEMBL289472 1019 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
10033116 208236 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98665 208236 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
11765177 117008 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 117008 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
16133225 419 52 None 1 4 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
172198 419 52 None 1 4 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
2504 419 52 None 1 4 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
45266664 419 52 None 1 4 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
5272 419 52 None 1 4 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL408403 419 52 None 1 4 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
DB11842 419 52 None 1 4 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL385433 212350 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2016.03.006
10259841 16158 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 16158 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10417195 109079 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321313 109079 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
10078554 116968 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116968 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10440174 167814 0 None - 0 Rat 10.0 pIC50 = 10 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 767 17 1 9 8.0 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL430659 167814 0 None - 0 Rat 10.0 pIC50 = 10 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 767 17 1 9 8.0 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL385189 212343 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cccs1)C(=O)O 10.1021/jm00108a043
10078800 109191 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissuesInhibitory concentration against AT1 receptor from rat adrenal tissues
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 109191 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissuesInhibitory concentration against AT1 receptor from rat adrenal tissues
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
9853391 116839 1 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116839 1 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9853391 116839 1 None - 0 Human 9.9 pIC50 = 9.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm9504722
CHEMBL338027 116839 1 None - 0 Human 9.9 pIC50 = 9.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm9504722
CHEMBL2391146 210412 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human angiotensin AT2 receptor by radioligand displacement assayBinding affinity to human angiotensin AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
10101351 168664 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168664 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259525 15619 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15619 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372810 106202 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL313868 106202 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
10078800 109191 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 109191 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10395335 117082 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 117082 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10033136 16073 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 16073 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
19430477 208131 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 8.1 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 10.1021/jm00015a016
CHEMBL98047 208131 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 8.1 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 10.1021/jm00015a016
10259468 118481 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 118481 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101606 15771 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15771 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10032988 116917 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116917 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10440179 107399 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL317962 107399 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10078780 116916 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116916 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259468 118481 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 118481 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259265 110043 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissues.Inhibitory concentration against AT1 receptor from rat adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 110043 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissues.Inhibitory concentration against AT1 receptor from rat adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10372659 118090 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 118090 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10327728 98122 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 98122 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10078554 116968 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116968 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10033116 208236 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98665 208236 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
44348523 113179 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 113179 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
10032877 15549 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15549 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
183134 204844 17 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL7550 204844 17 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10259525 15619 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15619 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010071 117349 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 117349 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292111 204745 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 204745 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL2392353 210414 6 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human AT2 receptor by radioligand displacement assayBinding affinity to human AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
10033136 16073 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 16073 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10439837 16353 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16353 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
10032820 117304 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 117304 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
9853391 116839 1 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116839 1 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101690 116861 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116861 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10440144 116894 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116894 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10439715 117035 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 117035 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314761 102854 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102854 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
44315344 105081 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 105081 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315078 204756 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 204756 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
15780085 118150 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL34082 118150 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10440144 116894 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116894 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10032988 116917 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116917 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101351 168664 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168664 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315078 204756 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 204756 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10033126 168137 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL433005 168137 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10078780 116916 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116916 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372451 117294 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 117294 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462683 113282 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 113282 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44283480 100468 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 9 1 8 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL290768 100468 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 9 1 8 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10259265 110043 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 110043 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10259265 110043 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL323506 110043 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462933 16882 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16882 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
19754068 102733 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL304946 102733 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10101606 15771 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15771 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10101608 117029 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 117029 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
44315282 96624 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96624 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
44315351 104885 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104885 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
9896750 4180 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm00015a016
CHEMBL100119 4180 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm00015a016
10372550 164516 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 164516 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439715 117035 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 117035 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987414 117049 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 117049 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
11765177 117008 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 117008 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10032851 16835 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16835 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314761 102854 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102854 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
9896750 4180 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm9504722
CHEMBL100119 4180 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm9504722
10032877 15549 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15549 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10009984 113180 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 113180 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
10078475 113330 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 113330 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987414 117049 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 117049 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010164 117397 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 117397 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765560 15537 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15537 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314822 102949 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102949 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9895877 53889 1 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 653 12 2 8 7.1 CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm9504722
CHEMBL160494 53889 1 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 653 12 2 8 7.1 CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm9504722
10439858 16861 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16861 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259447 16928 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16928 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
10010071 117349 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 117349 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292111 204745 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 204745 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19754061 102734 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL304947 102734 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
10462573 117009 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 117009 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10395335 117082 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 117082 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
44315349 60390 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60390 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10394859 17429 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17429 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
2583 3776 118 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
592 3776 118 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
65999 3776 118 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
CHEMBL1017 3776 118 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
DB00966 3776 118 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
10373120 117601 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117601 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
10394859 17429 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17429 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315351 104885 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104885 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
15780090 100455 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 631 9 1 7 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL290669 100455 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 631 9 1 7 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10101608 117029 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 117029 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10259841 16158 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 16158 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10372659 118090 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 118090 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314822 102949 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102949 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10373120 117601 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117601 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
44315144 96592 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96592 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10032851 16835 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16835 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395076 168576 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168576 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9874508 204680 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 204680 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9874508 204680 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1021/jm9504722
CHEMBL73876 204680 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1021/jm9504722
44338708 110444 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL324629 110444 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
22850667 200800 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 542 11 1 3 6.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL60071 200800 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 542 11 1 3 6.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10032820 117304 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 117304 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10462683 113282 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 113282 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314823 161886 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161886 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL938 215907 28 None -1 2 Human 9.4 pIC50 = 9.4 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm8007618
9809637 203852 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68618 203852 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
9830680 100643 0 None - 1 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
CHEMBL292150 100643 0 None - 1 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
15780094 99810 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 651 9 1 7 7.4 CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL285433 99810 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 651 9 1 7 7.4 CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL384352 212324 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 10.1021/jm00065a013
9917295 102958 17 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306407 102958 17 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
10417321 15618 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15618 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439819 169889 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169889 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292113 96033 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 96033 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10078800 109191 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 109191 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10485034 107186 1 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 719 17 1 9 7.1 CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL316503 107186 1 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 719 17 1 9 7.1 CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
15292113 96033 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 96033 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10462598 114136 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 114136 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10259447 16928 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16928 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL938 215907 28 None -1 2 Human 9.3 pIC50 = 9.3 Binding
Inhibition of human angiotensin II AT2 receptorInhibition of human angiotensin II AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmc.2010.07.034
10462933 16882 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16882 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462598 114136 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 114136 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10009984 113180 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 113180 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
15292112 102948 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102948 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44314780 103078 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 103078 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10101690 116861 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116861 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
8374 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
9937291 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
CHEMBL34124 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
DB16266 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
10327309 113891 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113891 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10372451 117294 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 117294 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
8374 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
9937291 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
CHEMBL34124 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
DB16266 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
44338834 7858 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL108981 7858 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44338834 7858 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL108981 7858 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44303887 203321 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64861 203321 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
8374 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
9937291 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
CHEMBL34124 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
DB16266 2922 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
44315344 105081 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 105081 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
16133225 419 52 None 1 4 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
172198 419 52 None 1 4 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
2504 419 52 None 1 4 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
45266664 419 52 None 1 4 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
5272 419 52 None 1 4 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
CHEMBL408403 419 52 None 1 4 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
DB11842 419 52 None 1 4 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
11765454 118068 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 118068 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10349897 114428 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 114428 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315058 70453 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70453 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315059 204712 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 204712 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10101606 15771 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15771 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL385283 212347 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
19430475 204252 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71125 204252 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F 10.1016/S0960-894X(00)80077-3
9940350 204758 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
CHEMBL74573 204758 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
9851889 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL302102 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
9940350 204758 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74573 204758 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
10031067 100352 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
CHEMBL289614 100352 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
10031067 100352 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL289614 100352 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
10031067 100352 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL289614 100352 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
44283174 100074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 7.2 CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL287250 100074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 7.2 CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9851889 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)80595-3
CHEMBL302102 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)80595-3
9851889 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81115-X
CHEMBL302102 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81115-X
9851889 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00019a004
CHEMBL302102 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00019a004
10395076 168576 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168576 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315058 70453 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70453 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9851889 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL302102 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44303886 100880 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL293660 100880 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9851889 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
CHEMBL302102 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
9851889 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm9504722
CHEMBL302102 102074 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm9504722
9851889 102074 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm058225d
CHEMBL302102 102074 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm058225d
44315057 204829 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 204829 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10078475 113330 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 113330 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44283175 120370 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 8 1 7 7.1 Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL35324 120370 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 8 1 7 7.1 Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44315304 205010 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 205010 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
44314823 161886 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161886 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
9874508 204680 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 204680 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10439819 169889 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169889 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44338697 109659 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 613 11 1 8 6.8 CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL322471 109659 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 613 11 1 8 6.8 CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
10372550 164516 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 164516 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
15292112 102948 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102948 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44314780 103078 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 103078 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10462573 117009 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 117009 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL414533 213136 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
10259265 110043 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 110043 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10327309 113891 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113891 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10439837 16353 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16353 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
9892451 48740 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155836 48740 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
10010164 117397 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 117397 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10032988 116917 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116917 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765454 118068 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 118068 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10100951 115044 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 115044 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
20647138 100472 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL290829 100472 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
9918412 204262 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL71172 204262 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
19430479 204269 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71220 204269 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
10462053 168057 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 664 15 4 8 5.9 CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL432378 168057 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 664 15 4 8 5.9 CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10327728 98122 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 98122 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315282 96624 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96624 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
9917399 102146 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL302519 102146 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
9917399 102146 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1021/jm9504722
CHEMBL302519 102146 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1021/jm9504722
44315349 60390 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60390 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44311675 102154 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL302579 102154 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311676 103061 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307318 103061 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311412 105329 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL311625 105329 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311072 204186 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70789 204186 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311736 204207 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70867 204207 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311452 204505 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL72595 204505 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
15780095 98595 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 595 9 1 7 6.5 CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL276853 98595 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 595 9 1 7 6.5 CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
15780091 120996 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 618 9 1 8 6.1 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL35638 120996 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 618 9 1 8 6.1 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9851082 101020 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(01)80554-0
CHEMBL294512 101020 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(01)80554-0
9810305 98572 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL276674 98572 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
9810305 98572 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL276674 98572 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
1037 1578 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
3940 1578 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
5281037 1578 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
588 1578 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
CHEMBL813 1578 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
DB00876 1578 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
9810305 98572 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98572 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44315144 96592 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96592 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9851082 101020 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
CHEMBL294512 101020 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
10395395 107294 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL317159 107294 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10033013 111653 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 750 17 1 10 7.3 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm00015a016
CHEMBL328602 111653 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 750 17 1 10 7.3 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm00015a016
9937227 202172 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
CHEMBL60942 202172 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
10078661 208247 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 17 1 9 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98746 208247 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 17 1 9 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10259277 208314 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 715 18 1 9 7.4 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 10.1021/jm00015a016
CHEMBL99112 208314 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 715 18 1 9 7.4 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 10.1021/jm00015a016
44315304 205010 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 205010 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315057 204829 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 204829 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL5272027 194610 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of angiotensin 2 (unknown origin)Inhibition of angiotensin 2 (unknown origin)
ChEMBL 846 21 4 9 8.0 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C.CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O 10.1016/j.ejmech.2019.111852
CHEMBL5315276 194610 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of angiotensin 2 (unknown origin)Inhibition of angiotensin 2 (unknown origin)
ChEMBL 846 21 4 9 8.0 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C.CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O 10.1016/j.ejmech.2019.111852
44322202 106871 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 692 17 4 8 6.7 CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL314506 106871 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 692 17 4 8 6.7 CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44322203 106934 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 650 13 4 8 5.4 CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL314827 106934 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 650 13 4 8 5.4 CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44321791 206613 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 698 14 4 8 6.0 CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89053 206613 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 698 14 4 8 6.0 CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10078554 116968 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116968 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765560 15537 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15537 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10417321 15618 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15618 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9810305 98572 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98572 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
10485116 116853 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 116853 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
18965174 100868 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 507 12 1 3 5.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL293625 100868 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 507 12 1 3 5.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9870559 46868 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 8 1 4 5.6 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL154057 46868 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 8 1 4 5.6 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 10.1016/S0960-894X(01)81122-7
19939495 207825 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory concentration against AT2 receptor from rat adrenal tissues.Inhibitory concentration against AT2 receptor from rat adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 207825 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory concentration against AT2 receptor from rat adrenal tissues.Inhibitory concentration against AT2 receptor from rat adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10010071 117349 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 117349 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL216061 209316 15 None - 2 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00108a043
10395335 117082 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 117082 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10349897 114428 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 114428 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439858 16861 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16861 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315060 103057 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 103057 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL938 215907 28 None -1 2 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm00065a013
15780089 99809 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 603 8 1 7 6.4 Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL285432 99809 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 603 8 1 7 6.4 Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10349732 118753 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL341828 118753 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
10101351 168664 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168664 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259489 16918 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
CHEMBL125231 16918 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
22850669 202986 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL63109 202986 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10321941 138147 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl 10.1021/jm00108a043
CHEMBL37679 138147 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl 10.1021/jm00108a043
20647138 100472 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
CHEMBL290829 100472 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
10033136 16073 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 16073 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10394859 17429 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17429 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
20647138 100472 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL290829 100472 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
19430442 204175 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL70726 204175 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
10078663 207787 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL96075 207787 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
10100951 115044 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL334300 115044 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
10078663 207787 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL96075 207787 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
44381553 120336 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352947 120336 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10100951 115044 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 115044 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44315350 105218 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 105218 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10417321 15618 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15618 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44348523 113179 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 113179 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
9870914 203327 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64881 203327 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44299731 420 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
585 420 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
CHEMBL56448 420 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
10395076 168576 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168576 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315059 204712 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 204712 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19430462 102984 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306638 102984 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(00)80077-3
44321824 205564 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 642 13 4 8 5.5 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL81236 205564 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 642 13 4 8 5.5 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
22402434 49027 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 1 5 5.8 COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81122-7
CHEMBL156100 49027 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 1 5 5.8 COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81122-7
44311617 102539 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL304065 102539 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 10.1016/S0960-894X(00)80077-3
44311538 102963 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL306435 102963 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311755 103134 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 18 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL307866 103134 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 18 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311071 103415 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 8.0 CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL308482 103415 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 8.0 CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 10.1016/S0960-894X(00)80077-3
44311752 104865 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL311018 104865 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 10.1016/S0960-894X(00)80077-3
10005139 57604 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 10.1016/j.bmc.2010.10.043
CHEMBL1668008 57604 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 10.1016/j.bmc.2010.10.043
14403498 101031 3 None - 0 Rat 8.0 pIC50 = 8 Binding
Binding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomesBinding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomes
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL294558 101031 3 None - 0 Rat 8.0 pIC50 = 8 Binding
Binding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomesBinding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomes
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
44303640 200113 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 511 12 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59611 200113 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 511 12 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 10.1016/S0960-894X(01)80554-0
44303208 202546 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 555 12 1 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL61168 202546 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 555 12 1 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 10.1016/S0960-894X(01)80554-0
44210590 58714 0 None - 0 Rat 8.0 pIC50 = 8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168490 58714 0 None - 0 Rat 8.0 pIC50 = 8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10078475 113330 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 113330 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
18965184 202916 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 504 4 0 2 7.3 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL62806 202916 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 504 4 0 2 7.3 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
44330905 4410 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 746 19 1 8 8.2 CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 10.1021/jm00015a016
CHEMBL101455 4410 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 746 19 1 8 8.2 CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 10.1021/jm00015a016
9937227 202172 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
CHEMBL60942 202172 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
11755896 116972 0 None - 0 Rat 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 505 7 1 3 5.8 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL338709 116972 0 None - 0 Rat 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 505 7 1 3 5.8 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
11765541 119008 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342605 119008 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9988057 106161 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 831 10 5 15 3.3 CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C 10.1016/0960-894X(95)00477-B
CHEMBL313691 106161 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 831 10 5 15 3.3 CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C 10.1016/0960-894X(95)00477-B
44311496 204244 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 722 15 2 8 7.2 CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL71069 204244 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 722 15 2 8 7.2 CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1016/S0960-894X(00)80076-1
44379292 120334 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 613 12 1 6 7.4 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352934 120334 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 613 12 1 6 7.4 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81125-2
10077497 11369 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
CHEMBL1179757 11369 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
CHEMBL98426 11369 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
44328276 112727 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL330464 112727 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10077929 207345 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 643 14 2 8 5.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1021/jm00043a020
CHEMBL93606 207345 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 643 14 2 8 5.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1021/jm00043a020
15818748 99913 0 None - 0 Human 7.0 pIC50 = 7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 543 9 1 5 5.7 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL286134 99913 0 None - 0 Human 7.0 pIC50 = 7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 543 9 1 5 5.7 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311571 204455 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL72249 204455 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303248 202753 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 414 8 1 6 4.4 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C 10.1016/S0960-894X(01)80554-0
CHEMBL61976 202753 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 414 8 1 6 4.4 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C 10.1016/S0960-894X(01)80554-0
44311567 103013 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 11 2 8 6.4 CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306922 103013 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 11 2 8 6.4 CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311450 104101 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 652 12 2 8 6.4 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309365 104101 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 652 12 2 8 6.4 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311497 167857 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 547 10 1 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL430997 167857 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 547 10 1 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311664 204163 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 680 12 2 8 5.9 CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70638 204163 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 680 12 2 8 5.9 CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44377125 55639 0 None - 0 Rat 6.0 pIC50 = 6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL162148 55639 0 None - 0 Rat 6.0 pIC50 = 6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
1610 2347 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
3941 2347 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
3961 2347 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
590 2347 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
CHEMBL191 2347 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
DB00678 2347 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
44376747 120089 0 None - 0 Rat 5.0 pIC50 = 5 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 510 11 2 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350851 120089 0 None - 0 Rat 5.0 pIC50 = 5 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 510 11 2 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
9852384 100416 5 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL290214 100416 5 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
9852384 100416 5 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm049715t
CHEMBL290214 100416 5 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm049715t
9852384 100416 5 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
CHEMBL290214 100416 5 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
23583071 188218 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1450 7 8 31 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL499234 188218 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1450 7 8 31 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
164613196 185439 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 951 23 12 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4861538 185439 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 951 23 12 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
10440203 118987 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342492 118987 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44315058 70453 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70453 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315344 105081 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 105081 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10258694 112587 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 10.1021/jm00043a020
CHEMBL330165 112587 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 10.1021/jm00043a020
10233073 207633 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 10.1021/jm00043a020
CHEMBL95198 207633 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 10.1021/jm00043a020
10438523 208144 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 10 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
CHEMBL98126 208144 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 10 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
57380412 70528 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947129 70528 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
15296724 120018 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 462 7 2 5 4.3 COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 10.1016/S0960-894X(01)81122-7
CHEMBL350220 120018 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 462 7 2 5 4.3 COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 10.1016/S0960-894X(01)81122-7
11757357 207992 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 552 9 1 6 5.8 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL97273 207992 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 552 9 1 6 5.8 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
23584461 178673 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1368 7 9 30 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL467872 178673 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1368 7 9 30 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
90663955 106776 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL 1280 38 16 17 0.0 CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O 10.1021/jm00065a013
CHEMBL3144487 106776 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL 1280 38 16 17 0.0 CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O 10.1021/jm00065a013
164625885 186266 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4873899 186266 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
44303458 167882 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 10.1016/S0960-894X(01)80554-0
CHEMBL431137 167882 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 10.1016/S0960-894X(01)80554-0
10417251 96905 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL265797 96905 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
19939453 112391 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL329679 112391 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10417251 96905 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL265797 96905 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL413925 213102 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 10.1021/jm00065a013
44381724 120308 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352771 120308 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
10259265 110043 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 110043 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
44315180 102896 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102896 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44373238 97087 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 1051 29 11 12 1.9 CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O 10.1021/jm9504722
CHEMBL267354 97087 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 1051 29 11 12 1.9 CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O 10.1021/jm9504722
44304147 100776 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 0 4 5.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 10.1016/S0960-894X(01)81007-6
CHEMBL292939 100776 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 0 4 5.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 10.1016/S0960-894X(01)81007-6
44315057 204829 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 204829 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44322236 112828 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 14 4 8 5.4 CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL330744 112828 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 14 4 8 5.4 CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44323447 106901 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 627 11 1 9 6.5 CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL314605 106901 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 627 11 1 9 6.5 CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379269 57168 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 644 12 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164769 57168 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 644 12 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
10438745 107216 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 10.1021/jm00043a020
CHEMBL316655 107216 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 10.1021/jm00043a020
10349597 111618 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 10.1021/jm00043a020
CHEMBL328434 111618 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 10.1021/jm00043a020
10416475 207704 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 10.1021/jm00043a020
CHEMBL95579 207704 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 10.1021/jm00043a020
44300735 100760 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 629 9 1 9 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL292829 100760 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 629 9 1 9 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
46910582 70353 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945009 70353 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
19385652 47518 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 459 9 1 6 5.3 CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15458 47518 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 459 9 1 6 5.3 CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
19385680 98881 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 487 10 1 6 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC 10.1016/0960-894X(95)00185-V
CHEMBL279103 98881 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 487 10 1 6 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC 10.1016/0960-894X(95)00185-V
15696755 148023 1 None - 0 Rat 4.9 pIC50 = 4.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 306 7 1 3 3.6 CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL39345 148023 1 None - 0 Rat 4.9 pIC50 = 4.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 306 7 1 3 3.6 CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
44323530 207180 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 586 10 1 8 5.1 CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL92479 207180 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 586 10 1 8 5.1 CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10259395 26995 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL136465 26995 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381552 120287 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352629 120287 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 10.1016/S0960-894X(01)81126-4
10349659 111543 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 10.1021/jm00043a020
CHEMBL327988 111543 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 10.1021/jm00043a020
10439275 168060 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 10.1021/jm00043a020
CHEMBL432392 168060 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 10.1021/jm00043a020
10054753 208146 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 629 9 2 7 5.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL98140 208146 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 629 9 2 7 5.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
44300615 196783 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 572 9 1 7 6.5 CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL56549 196783 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 572 9 1 7 6.5 CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
44373417 52383 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 10.1021/jm9504722
CHEMBL159004 52383 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 10.1021/jm9504722
57380649 70375 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945149 70375 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
11765394 118777 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C 10.1021/jm00052a006
CHEMBL341986 118777 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C 10.1021/jm00052a006
19939409 107160 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 710 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316299 107160 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 710 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
136026557 206862 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 617 11 1 10 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL90663 206862 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 617 11 1 10 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00477-B
44309903 204394 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL71925 204394 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
19939495 207825 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 207825 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
44309903 204394 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL71925 204394 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
44270330 51746 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 10 1 5 6.2 CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15847 51746 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 10 1 5 6.2 CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
57380647 70354 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945010 70354 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
10349791 111579 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm00043a020
CHEMBL328176 111579 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm00043a020
10008962 119273 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343719 119273 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
73347893 92626 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435828 92626 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
10484866 31785 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL140619 31785 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
44322097 107106 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 608 12 4 8 4.6 CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315994 107106 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 608 12 4 8 4.6 CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381425 120454 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353980 120454 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
18965154 100600 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 490 4 0 2 6.9 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL291818 100600 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 490 4 0 2 6.9 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
44303880 202973 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 12 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 10.1016/S0960-894X(01)81007-6
CHEMBL63046 202973 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 12 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 10.1016/S0960-894X(01)81007-6
44304044 203186 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 7 1 3 4.3 CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64280 203186 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 7 1 3 4.3 CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44323293 107033 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 629 14 1 9 6.8 CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O 10.1016/0960-894X(95)00477-B
CHEMBL315483 107033 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 629 14 1 9 6.8 CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O 10.1016/0960-894X(95)00477-B
44323357 112387 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 648 11 1 8 6.7 CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL329655 112387 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 648 11 1 8 6.7 CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323352 206550 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 9 1 9 5.2 CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88663 206550 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 9 1 9 5.2 CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10326775 112239 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 10.1021/jm00043a020
CHEMBL329089 112239 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 10.1021/jm00043a020
10483726 207576 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL94910 207576 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00043a020
10349506 208059 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 10.1021/jm00043a020
CHEMBL97615 208059 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 10.1021/jm00043a020
44300637 100925 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 600 11 1 7 7.2 CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL293949 100925 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 600 11 1 7 7.2 CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
10100413 198590 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 620 9 1 7 7.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL57853 198590 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 620 9 1 7 7.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
15296725 165285 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 535 9 0 5 5.9 CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL423236 165285 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 535 9 0 5 5.9 CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
46910583 70352 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945008 70352 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
44379348 164921 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 558 10 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL422374 164921 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 558 10 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
10439172 207483 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 644 13 2 8 5.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 10.1021/jm00043a020
CHEMBL94355 207483 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 644 13 2 8 5.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 10.1021/jm00043a020
44377171 120211 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 485 6 1 8 5.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 10.1016/S0960-894X(01)80193-1
CHEMBL352042 120211 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 485 6 1 8 5.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 10.1016/S0960-894X(01)80193-1
15287894 54947 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(95)00185-V
CHEMBL16148 54947 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(95)00185-V
44381739 58785 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168771 58785 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
44381739 58785 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL168771 58785 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
10326797 207574 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
CHEMBL94905 207574 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
10326460 208107 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 614 9 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL97897 208107 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 614 9 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 10.1021/jm00043a020
44327912 208135 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC 10.1021/jm00043a020
CHEMBL98068 208135 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC 10.1021/jm00043a020
44348153 117970 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 10.1021/jm00075a033
CHEMBL340367 117970 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 10.1021/jm00075a033
44210836 56509 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 453 6 1 8 3.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 10.1016/S0960-894X(01)80193-1
CHEMBL163523 56509 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 453 6 1 8 3.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 10.1016/S0960-894X(01)80193-1
73357017 92629 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 483 10 2 4 6.2 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435831 92629 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 483 10 2 4 6.2 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
44323532 207134 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL92206 207134 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
9830680 100643 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL292150 100643 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
9830680 100643 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL292150 100643 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
10372497 118746 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341783 118746 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9830680 100643 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL292150 100643 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00043a020
10078800 109191 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 109191 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
9830680 100643 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm9504722
CHEMBL292150 100643 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm9504722
19754050 203880 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 603 15 2 7 6.6 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68786 203880 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 603 15 2 7 6.6 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 10.1016/S0960-894X(01)81115-X
44381528 58993 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 548 10 2 8 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169009 58993 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 548 10 2 8 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10394995 111394 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 10.1021/jm00043a020
CHEMBL327191 111394 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 10.1021/jm00043a020
10077743 207957 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1021/jm00043a020
CHEMBL97068 207957 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1021/jm00043a020
44304148 203289 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 458 4 1 3 4.3 CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL64714 203289 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 458 4 1 3 4.3 CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 10.1016/S0960-894X(01)81007-6
22402428 48751 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 450 6 2 4 4.5 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155847 48751 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 450 6 2 4 4.5 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 10.1016/S0960-894X(01)81122-7
15229605 48154 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 463 7 1 5 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL15517 48154 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 463 7 1 5 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 10.1016/0960-894X(95)00185-V
44323448 96850 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 559 10 2 8 5.1 CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL265291 96850 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 559 10 2 8 5.1 CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
11764788 100858 0 None - 1 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL293501 100858 0 None - 1 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9810305 98572 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98572 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
9895212 119640 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL346728 119640 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
44385182 61074 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 637 10 3 7 5.7 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL176473 61074 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 637 10 3 7 5.7 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
10031920 107987 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 10.1021/jm00043a020
CHEMBL319404 107987 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 10.1021/jm00043a020
44372814 119790 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 672 11 2 6 6.7 CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1021/jm9504722
CHEMBL348157 119790 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 672 11 2 6 6.7 CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1021/jm9504722
44303888 203279 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 552 12 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64674 203279 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 552 12 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10390872 116146 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00050a002
CHEMBL335778 116146 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00050a002
44377086 119951 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 546 11 2 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349652 119951 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 546 11 2 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
10101582 119376 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1021/jm00052a006
CHEMBL344466 119376 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1021/jm00052a006
5311348 100673 4 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1016/S0960-894X(01)81007-6
CHEMBL292277 100673 4 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1016/S0960-894X(01)81007-6
10484986 118697 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341715 118697 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
1952 2209 4 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
5312129 2209 4 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
CHEMBL1182768 2209 4 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
9960852 107182 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL316482 107182 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10416957 111499 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 10.1021/jm00043a020
CHEMBL327791 111499 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 10.1021/jm00043a020
10010125 208031 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97464 208031 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 10.1021/jm00043a020
136059719 189129 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1438 10 9 31 4.5 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL510526 189129 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1438 10 9 31 4.5 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
44300827 101767 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 602 8 1 7 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL299897 101767 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 602 8 1 7 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
44348355 113387 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 10.1021/jm00075a033
CHEMBL331797 113387 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 10.1021/jm00075a033
44311289 102225 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL302964 102225 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311455 102744 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305017 102744 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311754 102997 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 757 16 1 9 9.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL306761 102997 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 757 16 1 9 9.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311715 103196 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL308323 103196 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311435 204022 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL69721 204022 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311434 204124 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70370 204124 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311414 204223 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70935 204223 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311413 204351 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71639 204351 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311753 204611 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL73283 204611 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
3936 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
6603900 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
CHEMBL288174 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
44303191 167886 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 529 12 1 7 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL431162 167886 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 529 12 1 7 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 10.1016/S0960-894X(01)80554-0
3936 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
6603900 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
CHEMBL288174 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
3936 2210 35 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
6603900 2210 35 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
CHEMBL288174 2210 35 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
44322095 107010 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315327 107010 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10259841 16158 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 16158 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10259447 16928 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16928 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
11765177 117008 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 117008 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
3936 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
6603900 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
CHEMBL288174 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
44372744 52151 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 10.1021/jm9504722
CHEMBL158795 52151 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 10.1021/jm9504722
3936 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
6603900 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
CHEMBL288174 2210 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
19430458 204074 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL70100 204074 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 10.1016/S0960-894X(00)80077-3
10010234 98427 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL275552 98427 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10078320 206515 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 684 13 4 8 5.8 CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL88446 206515 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 684 13 4 8 5.8 CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381426 120272 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352502 120272 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10349897 114428 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 114428 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259489 16918 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
CHEMBL125231 16918 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
10078780 116916 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116916 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259468 118481 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 118481 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44309938 204300 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL71388 204300 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
19802473 198705 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 415 5 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL58156 198705 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 415 5 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10439862 118772 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341934 118772 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10010195 119184 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343142 119184 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10032851 16835 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16835 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10485116 116853 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL338101 116853 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
9895984 204749 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL74476 204749 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10485116 116853 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 116853 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
10372810 106202 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL313868 106202 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
44315180 102896 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102896 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9895984 204749 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
CHEMBL74476 204749 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
9892451 48740 23 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155836 48740 23 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
9895984 204749 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1021/jm9504722
CHEMBL74476 204749 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1021/jm9504722
10101284 207402 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL93907 207402 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
10101284 207402 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL93907 207402 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
16133225 419 52 None 1 4 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
172198 419 52 None 1 4 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
2504 419 52 None 1 4 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
45266664 419 52 None 1 4 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
5272 419 52 None 1 4 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
CHEMBL408403 419 52 None 1 4 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
DB11842 419 52 None 1 4 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
11765560 15537 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15537 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10010071 117349 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 117349 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10101284 207402 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
CHEMBL93907 207402 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
44315060 103057 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 103057 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
10032877 15549 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15549 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10462683 113282 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 113282 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10417195 109079 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321313 109079 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
44310069 203738 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67801 203738 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10009984 113180 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 113180 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
44303884 202833 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62422 202833 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44381403 59166 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169968 59166 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10259657 119393 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344597 119393 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381413 120722 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354779 120722 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
9987414 117049 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 117049 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44311453 204037 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL69839 204037 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311557 204283 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL71286 204283 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311558 204722 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74236 204722 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44303388 162907 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 539 12 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL417393 162907 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 539 12 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 10.1016/S0960-894X(01)80554-0
44303459 200287 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 586 13 1 10 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)80554-0
CHEMBL59728 200287 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 586 13 1 10 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)80554-0
44303197 202236 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 619 12 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60992 202236 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 619 12 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 10.1016/S0960-894X(01)80554-0
10394727 103062 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 672 15 2 9 5.4 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL307321 103062 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 672 15 2 9 5.4 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
44210589 58596 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168413 58596 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
11765454 118068 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 118068 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10092454 100247 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II induced contractions in rabbit aortic ringsInhibition of Angiotensin II induced contractions in rabbit aortic rings
ChEMBL 401 7 2 5 4.9 CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00037a014
CHEMBL288705 100247 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II induced contractions in rabbit aortic ringsInhibition of Angiotensin II induced contractions in rabbit aortic rings
ChEMBL 401 7 2 5 4.9 CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00037a014
44303859 200991 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 514 8 1 3 5.8 CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL60209 200991 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 514 8 1 3 5.8 CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 10.1016/S0960-894X(01)81007-6
9896877 60232 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 748 6 1 8 8.3 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
CHEMBL174080 60232 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 748 6 1 8 8.3 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
44311584 102780 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 695 16 1 8 8.1 CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL305239 102780 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 695 16 1 8 8.1 CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80077-3
44311406 103807 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL309081 103807 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10480819 21806 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 492 6 1 3 6.1 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL131940 21806 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 492 6 1 3 6.1 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
44311635 102224 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 581 10 2 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(00)80076-1
CHEMBL302959 102224 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 581 10 2 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(00)80076-1
44311499 204399 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 557 17 2 7 6.6 CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
CHEMBL71953 204399 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 557 17 2 7 6.6 CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
44384389 129837 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 10.1016/0960-894X(96)00116-3
CHEMBL367569 129837 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 10.1016/0960-894X(96)00116-3
10429298 18902 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL128416 18902 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
44210864 148105 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 503 8 1 5 4.8 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39352 148105 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 503 8 1 5 4.8 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
9850811 154740 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 561 8 1 6 5.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39996 154740 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 561 8 1 6 5.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311616 102140 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL302485 102140 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311776 103015 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306924 103015 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10255071 163464 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 0 4 5.6 COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL419974 163464 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 0 4 5.6 COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
9981762 163466 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 5 0 3 5.6 COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL419979 163466 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 5 0 3 5.6 COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44379347 120487 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 544 9 1 7 4.3 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL354338 120487 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 544 9 1 7 4.3 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44377075 119977 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 479 10 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349869 119977 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 479 10 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
15287882 49743 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 414 9 1 4 5.6 CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15670 49743 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 414 9 1 4 5.6 CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
22407453 49758 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15671 49758 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
9987311 116757 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL337588 116757 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
14952914 154910 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 410 9 2 5 5.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 10.1021/jm00108a043
CHEMBL40089 154910 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 410 9 2 5 5.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 10.1021/jm00108a043
44338666 110958 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 9 1 8 5.5 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL326217 110958 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 9 1 8 5.5 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44379335 120221 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 574 10 2 6 6.0 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352137 120221 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 574 10 2 6 6.0 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1016/S0960-894X(01)81125-2
44379293 120290 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 611 10 1 6 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352639 120290 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 611 10 1 6 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1016/S0960-894X(01)81125-2
44376780 56504 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 509 10 1 7 4.1 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL163486 56504 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 509 10 1 7 4.1 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
44300734 101806 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 586 9 1 7 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL300154 101806 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 586 9 1 7 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10049400 155440 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(94)00476-V
CHEMBL40381 155440 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(94)00476-V
44323358 112505 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 626 10 1 8 6.0 CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL329887 112505 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 626 10 1 8 6.0 CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
19939398 107334 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 10.1021/jm00043a020
CHEMBL317547 107334 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 10.1021/jm00043a020
10055534 157461 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL407919 157461 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 10.1021/jm00043a020
44338833 9179 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 537 9 2 8 5.4 CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL110265 9179 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 537 9 2 8 5.4 CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
15231091 93988 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24861 93988 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
15231091 93988 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL24861 93988 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL443325 213921 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSSC[C@H](C(=O)N[C@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C[C@H](CN1C(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)SS2 10.1021/jm00065a013
44303857 100810 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O 10.1016/S0960-894X(01)81007-6
CHEMBL293195 100810 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O 10.1016/S0960-894X(01)81007-6
10417144 32980 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL141592 32980 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44303852 102349 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 524 11 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL303755 102349 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 524 11 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
18950586 15564 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm00075a033
CHEMBL122017 15564 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm00075a033
44377058 120006 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350121 120006 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
10482937 167137 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL321086 167137 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL429058 167137 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
14956757 67593 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00052a006
CHEMBL19018 67593 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00052a006
14956757 67593 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00043a020
CHEMBL19018 67593 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00043a020
4189 206922 96 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 206922 96 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 206922 96 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
71455883 83764 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
CHEMBL2205685 83764 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
44372686 96655 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 600 4 2 7 6.2 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O 10.1021/jm9504722
CHEMBL263714 96655 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 600 4 2 7 6.2 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O 10.1021/jm9504722
44211677 130614 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 614 4 2 7 6.6 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
CHEMBL368149 130614 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 614 4 2 7 6.6 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
164623569 186187 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1008 26 12 10 2.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4872735 186187 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1008 26 12 10 2.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
44348302 16491 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm00075a033
CHEMBL123562 16491 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm00075a033
11764826 98284 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1021/jm00043a020
CHEMBL274710 98284 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1021/jm00043a020
44348302 16491 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm9504722
CHEMBL123562 16491 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm9504722
10028460 116521 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00050a002
CHEMBL336180 116521 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00050a002
10349512 208007 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97332 208007 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm00043a020
19385665 51061 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 9 1 5 6.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C 10.1016/0960-894X(95)00185-V
CHEMBL15788 51061 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 9 1 5 6.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C 10.1016/0960-894X(95)00185-V
10028815 208095 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 496 8 1 6 4.4 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 10.1021/jm00043a020
CHEMBL97783 208095 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 496 8 1 6 4.4 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 10.1021/jm00043a020
CHEMBL411657 212954 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CSS2)N(C(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C1 10.1021/jm00065a013
10078397 12109 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL1184032 12109 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL329290 12109 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
168298448 192703 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 477 5 2 4 5.8 O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
CHEMBL5219534 192703 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 477 5 2 4 5.8 O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
44211576 107118 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 10 1 9 5.2 CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL316063 107118 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 10 1 9 5.2 CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
136059721 188998 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1537 12 10 33 3.3 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL508699 188998 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1537 12 10 33 3.3 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
10429298 18902 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128416 18902 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44300838 198670 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 530 7 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL57976 198670 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 530 7 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10009968 112547 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 10.1021/jm00043a020
CHEMBL329942 112547 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 10.1021/jm00043a020
10372341 168198 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 10.1021/jm00043a020
CHEMBL433375 168198 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 10.1021/jm00043a020
16725318 188963 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1494 11 9 32 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL508306 188963 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1494 11 9 32 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
192626 15659 14 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 499 11 1 5 6.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 10.1021/jm00075a033
CHEMBL122212 15659 14 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 499 11 1 5 6.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 10.1021/jm00075a033
9978845 130712 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 408 9 1 3 5.6 CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL36846 130712 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 408 9 1 3 5.6 CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL417584 213235 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
9939191 98946 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98946 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98946 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
10326972 112261 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 10.1021/jm00043a020
CHEMBL329099 112261 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 10.1021/jm00043a020
10077555 207410 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 10.1021/jm00043a020
CHEMBL93956 207410 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 10.1021/jm00043a020
19102815 207878 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL96554 207878 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
19385603 98779 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 455 9 1 5 5.6 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL278234 98779 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 455 9 1 5 5.6 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL408885 212736 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
19754062 102985 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 604 13 3 7 5.9 CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306641 102985 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 604 13 3 7 5.9 CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10349029 208096 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 10.1021/jm00043a020
CHEMBL97812 208096 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 10.1021/jm00043a020
9888865 57497 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 429 6 1 6 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 10.1016/S0960-894X(01)80193-1
CHEMBL165974 57497 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 429 6 1 6 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 10.1016/S0960-894X(01)80193-1
10055448 30763 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139582 30763 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44379334 58111 1 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 585 10 2 9 4.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167584 58111 1 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 585 10 2 9 4.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81125-2
44381603 59116 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 532 8 2 7 3.8 CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169798 59116 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 532 8 2 7 3.8 CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/S0960-894X(01)81126-4
133031 100859 21 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00017-0
CHEMBL293511 100859 21 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00017-0
133031 100859 21 None - 1 Rat 5.5 pIC50 = 5.5 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00050a002
CHEMBL293511 100859 21 None - 1 Rat 5.5 pIC50 = 5.5 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00050a002
19385675 51374 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 445 8 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
CHEMBL15816 51374 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 445 8 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
44311537 102332 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL303647 102332 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311580 102779 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305238 102779 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311182 103027 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307008 103027 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311619 103070 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL307359 103070 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311185 104191 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL309790 104191 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311073 204200 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70843 204200 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311184 204421 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL72099 204421 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311183 204700 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74069 204700 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311735 204752 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74514 204752 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9937227 202172 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60942 202172 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1016/S0960-894X(01)80554-0
9851082 101020 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL294512 101020 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
9987283 161942 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 705 16 1 9 6.7 CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL415502 161942 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 705 16 1 9 6.7 CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
133031 100859 21 None - 1 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL293511 100859 21 None - 1 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
9937227 202172 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm9504722
CHEMBL60942 202172 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm9504722
10032820 117304 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 117304 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10372659 118090 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 118090 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315351 104885 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104885 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
44381402 59165 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169967 59165 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
15780064 99623 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 613 10 1 8 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL284123 99623 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 613 10 1 8 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44381671 120427 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353800 120427 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
15292113 96033 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 96033 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10032858 29761 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
CHEMBL138690 29761 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
9853391 116839 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116839 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439715 117035 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 117035 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10350123 57603 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 713 12 1 9 6.0 CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F 10.1016/j.bmc.2010.10.043
CHEMBL1668007 57603 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 713 12 1 9 6.0 CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F 10.1016/j.bmc.2010.10.043
19939418 108270 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL319730 108270 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
19939495 207825 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 207825 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10395335 117082 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 117082 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
44315144 96592 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96592 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44381527 59074 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169568 59074 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
44210588 120345 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353037 120345 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10440144 116894 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116894 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462573 117009 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 117009 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44382947 59233 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 813 19 4 12 6.4 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/S0960-894X(00)80690-3
CHEMBL170290 59233 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 813 19 4 12 6.4 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/S0960-894X(00)80690-3
10101608 117029 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 117029 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10372451 117294 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 117294 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010164 117397 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 117397 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101284 207402 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
CHEMBL93907 207402 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
9850834 154662 17 None - 1 Rat 8.4 pIC50 = 8.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL39959 154662 17 None - 1 Rat 8.4 pIC50 = 8.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
10032988 116917 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116917 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44321825 107110 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL316021 107110 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44309700 103185 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 651 13 2 7 7.2 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL308237 103185 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 651 13 2 7 7.2 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10433752 18921 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128527 18921 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44283372 100420 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
CHEMBL290286 100420 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
9875044 208029 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 10.1021/jm00043a020
CHEMBL97446 208029 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 10.1021/jm00043a020
44303835 101766 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)81007-6
CHEMBL299887 101766 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)81007-6
44283372 100420 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm9504722
CHEMBL290286 100420 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm9504722
44311609 102808 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL305369 102808 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311428 102969 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 647 17 1 8 7.1 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306473 102969 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 647 17 1 8 7.1 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311583 204120 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL70353 204120 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
11740800 18837 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 385 4 1 2 4.2 Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
CHEMBL128065 18837 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 385 4 1 2 4.2 Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
10386376 18937 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 402 4 1 3 4.5 CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 10.1021/jm00077a001
CHEMBL128594 18937 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 402 4 1 3 4.5 CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 10.1021/jm00077a001
9939191 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
CHEMBL279629 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
CHEMBL97539 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
44323387 105987 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 600 11 2 8 5.6 CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL313142 105987 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 600 11 2 8 5.6 CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323364 111900 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 599 10 1 8 6.6 CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328780 111900 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 599 10 1 8 6.6 CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44311758 204671 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 626 12 3 7 6.7 CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL73780 204671 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 626 12 3 7 6.7 CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
9939191 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
44379350 120785 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 599 10 1 7 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL355443 120785 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 599 10 1 7 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1016/S0960-894X(01)81125-2
9939191 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
CHEMBL279629 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
CHEMBL97539 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
9939191 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL279629 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97539 98946 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10348847 112589 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 615 10 2 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1021/jm00043a020
CHEMBL330170 112589 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 615 10 2 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1021/jm00043a020
10054912 207632 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 10.1021/jm00043a020
CHEMBL95197 207632 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 10.1021/jm00043a020
10054827 164138 0 None - 1 Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL42101 164138 0 None - 1 Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
19385729 50879 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15774 50879 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 10.1016/0960-894X(95)00185-V
15818746 124069 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 529 8 1 5 5.3 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL36324 124069 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 529 8 1 5 5.3 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311775 103014 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306923 103014 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303636 169098 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 418 8 1 6 4.2 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(01)80554-0
CHEMBL439936 169098 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 418 8 1 6 4.2 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(01)80554-0
44311681 103023 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 592 11 2 9 4.8 CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306961 103023 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 592 11 2 9 4.8 CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44384870 60046 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL173643 60046 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(96)00116-3
44270285 99065 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.7 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL280456 99065 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.7 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
9980304 98536 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 433 9 3 8 1.4 CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 10.1021/jm00053a013
CHEMBL276381 98536 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 433 9 3 8 1.4 CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 10.1021/jm00053a013
10258916 29711 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL138654 29711 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
14952906 100505 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] 10.1021/jm00108a043
CHEMBL291086 100505 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] 10.1021/jm00108a043
11764788 100858 0 None - 1 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
CHEMBL293501 100858 0 None - 1 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
10439253 112321 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 10.1021/jm00043a020
CHEMBL329255 112321 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 10.1021/jm00043a020
164611280 184999 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4854474 184999 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10077328 206472 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 601 11 1 9 6.0 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88170 206472 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 601 11 1 9 6.0 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44315060 103057 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 103057 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
44404967 135418 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
CHEMBL372814 135418 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
44323345 107004 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 557 10 1 8 5.6 CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315302 107004 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 557 10 1 8 5.6 CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10372723 107318 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL317368 107318 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00043a020
15231094 139297 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 641 12 1 8 7.4 CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL37919 139297 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 641 12 1 8 7.4 CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44309719 203854 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68638 203854 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
44323365 112075 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparationIn vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparation
ChEMBL 619 11 1 8 6.9 CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328997 112075 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparationIn vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparation
ChEMBL 619 11 1 8 6.9 CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379270 56857 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 580 9 1 7 5.2 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164395 56857 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 580 9 1 7 5.2 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
10010027 208032 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97465 208032 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 10.1021/jm00043a020
130762 98247 9 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00053a013
CHEMBL274447 98247 9 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00053a013
44270306 52177 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15882 52177 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 10.1016/0960-894X(95)00185-V
5311345 3021 46 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
597 3021 46 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
CHEMBL321820 3021 46 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
10394712 119377 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344467 119377 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
122189454 123256 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 497 7 1 5 4.1 COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C 10.1016/j.bmc.2015.07.045
CHEMBL3613974 123256 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 497 7 1 5 4.1 COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C 10.1016/j.bmc.2015.07.045
5311345 3021 46 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
597 3021 46 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
CHEMBL321820 3021 46 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
44379217 58149 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 608 10 2 6 7.1 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167929 58149 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 608 10 2 6 7.1 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
15287883 98210 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL274260 98210 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
10461785 11923 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
CHEMBL1182712 11923 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
CHEMBL262296 11923 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
10032342 208022 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 10.1021/jm00043a020
CHEMBL97394 208022 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 10.1021/jm00043a020
44303941 203255 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 580 13 1 5 6.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64575 203255 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 580 13 1 5 6.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
22402431 49100 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 575 8 1 4 6.8 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156165 49100 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 575 8 1 4 6.8 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 10.1016/S0960-894X(01)81122-7
44384871 129320 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 726 14 1 7 8.0 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
CHEMBL367095 129320 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 726 14 1 7 8.0 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
18950609 16405 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl 10.1021/jm00075a033
CHEMBL123084 16405 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl 10.1021/jm00075a033
44321626 105966 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 616 14 3 9 4.8 CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL313005 105966 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 616 14 3 9 4.8 CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
9809961 107161 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316300 107161 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
9809961 107161 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL316300 107161 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9809961 107161 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
CHEMBL316300 107161 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
44323350 107019 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315400 107019 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
57380414 70530 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947131 70530 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
10028545 21005 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm00050a002
CHEMBL131156 21005 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm00050a002
10009273 107225 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL316706 107225 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
15236320 172606 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 548 10 1 7 6.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL449095 172606 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 548 10 1 7 6.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
44315059 204712 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 204712 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
2911265 100842 13 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 476 4 0 2 6.5 O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL293414 100842 13 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 476 4 0 2 6.5 O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
183134 204844 17 None - 1 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL7550 204844 17 None - 1 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
9938088 102481 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
CHEMBL304022 102481 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
15230315 54437 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 552 8 0 7 5.7 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL160930 54437 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 552 8 0 7 5.7 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
14403498 101031 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81007-6
CHEMBL294558 101031 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81007-6
44322234 206708 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 8 5.1 CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89769 206708 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 8 5.1 CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
9986299 158451 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 10.1021/jm00043a020
CHEMBL409058 158451 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 10.1021/jm00043a020
44322235 112649 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 7 6.0 CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL330302 112649 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 7 6.0 CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10032193 119145 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342843 119145 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44211506 57541 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 557 10 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL166338 57541 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 557 10 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44311456 102298 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL303427 102298 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
71611145 184862 2 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1072 29 14 13 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4852514 184862 2 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1072 29 14 13 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
44303195 203214 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL64411 203214 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 10.1016/S0960-894X(01)80554-0
44331176 208355 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 7.8 CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL99438 208355 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 7.8 CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10010311 30527 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139325 30527 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10327728 98122 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 98122 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10439819 169889 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169889 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9850834 154662 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
CHEMBL39959 154662 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
9850834 154662 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL39959 154662 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
9850834 154662 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL39959 154662 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
19102786 207189 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL92533 207189 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
44309702 203740 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 591 13 2 8 6.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67805 203740 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 591 13 2 8 6.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10439837 16353 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16353 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
10462598 114136 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 114136 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10327537 116677 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL337118 116677 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10439848 119210 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343309 119210 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9852499 120463 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354080 120463 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 10.1016/S0960-894X(01)81126-4
44314761 102854 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102854 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
44315350 105218 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 105218 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44304123 200577 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL59913 200577 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44210585 120407 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81126-4
CHEMBL353615 120407 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81126-4
10327309 113891 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113891 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
44322096 98401 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 622 12 4 8 4.8 CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL275449 98401 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 622 12 4 8 4.8 CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10259411 30658 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139452 30658 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL408886 212737 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 10.1021/jm00065a013
22402420 49062 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 521 9 1 4 5.5 COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156129 49062 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 521 9 1 4 5.5 COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
19939454 207557 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 761 15 2 8 8.2 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL94793 207557 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 761 15 2 8 8.2 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
10003751 18838 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128066 18838 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
5311348 100673 4 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm00077a001
CHEMBL292277 100673 4 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm00077a001
10455982 116647 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 441 8 1 2 5.6 CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
CHEMBL336991 116647 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 441 8 1 2 5.6 CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
10435148 118134 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 477 6 1 3 5.5 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL340778 118134 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 477 6 1 3 5.5 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
44303430 101034 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 541 12 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL294578 101034 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 541 12 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 10.1016/S0960-894X(01)80554-0
44303878 98691 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 5 1 3 4.3 CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C 10.1016/S0960-894X(01)81007-6
CHEMBL277567 98691 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 5 1 3 4.3 CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C 10.1016/S0960-894X(01)81007-6
22402433 49597 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 2 5 5.2 COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156587 49597 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 2 5 5.2 COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
9851082 101020 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL294512 101020 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
44311543 104141 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 643 14 1 8 6.3 CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL309455 104141 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 643 14 1 8 6.3 CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10410436 117804 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 430 5 1 3 4.4 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL340187 117804 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 430 5 1 3 4.4 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 10.1021/jm00077a001
18950592 16790 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 10.1021/jm00075a033
CHEMBL124541 16790 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 10.1021/jm00075a033
44309902 103117 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL307757 103117 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
44311663 204189 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 561 10 2 7 5.8 CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70796 204189 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 561 10 2 7 5.8 CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311569 204704 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 625 13 2 7 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL74113 204704 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 625 13 2 7 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44381714 59121 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 732 11 1 7 7.6 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169827 59121 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 732 11 1 7 7.6 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
10416501 112410 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 9 1 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL329759 112410 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 9 1 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
10349392 208050 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 10.1021/jm00043a020
CHEMBL97557 208050 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 10.1021/jm00043a020
44311607 204183 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 517 9 3 8 4.5 CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70770 204183 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 517 9 3 8 4.5 CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44211673 59720 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 678 4 1 8 6.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL172376 59720 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 678 4 1 8 6.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
44300826 198738 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL58291 198738 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10099830 108491 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 584 9 1 7 4.9 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
CHEMBL319955 108491 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 584 9 1 7 4.9 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
44270278 98864 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 443 8 1 5 5.4 CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL278983 98864 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 443 8 1 5 5.4 CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
73349424 92631 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 495 7 1 4 6.3 CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435833 92631 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 495 7 1 4 6.3 CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
44379268 120054 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL350554 120054 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
10417431 109108 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 10.1021/jm00043a020
CHEMBL321363 109108 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 10.1021/jm00043a020
44322967 167942 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 712 15 1 10 7.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 10.1016/0960-894X(95)00477-B
CHEMBL431592 167942 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 712 15 1 10 7.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 10.1016/0960-894X(95)00477-B
10032583 12349 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
CHEMBL1185398 12349 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
CHEMBL411487 12349 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
3082918 95069 1 None - 0 Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 340 7 1 3 4.2 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL25528 95069 1 None - 0 Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 340 7 1 3 4.2 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
60148656 92627 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435829 92627 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
44322233 111630 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 644 12 2 11 4.5 CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL328480 111630 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 644 12 2 11 4.5 CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10047444 100347 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL289543 100347 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
10010047 207951 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 10.1021/jm00043a020
CHEMBL97020 207951 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 10.1021/jm00043a020
164611656 184737 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1067 27 14 12 0.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4850726 184737 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1067 27 14 12 0.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
44348408 113573 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm00075a033
CHEMBL332239 113573 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm00075a033
10055096 98285 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL274712 98285 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10054188 207521 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 592 9 1 7 5.1 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL94582 207521 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 592 9 1 7 5.1 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
9939191 98946 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL279629 98946 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL97539 98946 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
9829012 92556 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24322 92556 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
9829012 92556 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL24322 92556 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44376781 56272 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 517 10 2 6 4.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL162859 56272 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 517 10 2 6 4.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
9829012 92556 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
CHEMBL24322 92556 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
9895635 112023 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 10.1021/jm00043a020
CHEMBL328941 112023 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 10.1021/jm00043a020
10484119 168108 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL432822 168108 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 10.1021/jm00043a020
10075750 107558 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 532 10 1 7 4.8 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL318891 107558 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 532 10 1 7 4.8 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
44323291 206541 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.4 CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88600 206541 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.4 CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10095637 49967 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15689 49967 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
10009735 158205 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 676 3 1 7 6.9 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL408798 158205 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 676 3 1 7 6.9 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 10.1016/0960-894X(96)00116-3
10004112 25530 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm9504722
CHEMBL135089 25530 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm9504722
44311683 105618 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL312301 105618 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311618 163337 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL419073 163337 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311581 167833 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL430792 167833 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311415 204085 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70161 204085 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311582 204208 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70868 204208 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44321790 206612 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 634 13 4 8 4.9 C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89052 206612 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 634 13 4 8 4.9 C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381656 120268 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352458 120268 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
44330904 4346 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 698 19 1 8 7.3 CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL101039 4346 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 698 19 1 8 7.3 CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10373120 117601 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117601 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
15284887 165480 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 607 6 2 5 4.7 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O 10.1016/S0960-894X(00)80690-3
CHEMBL424004 165480 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 607 6 2 5 4.7 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O 10.1016/S0960-894X(00)80690-3
44381427 120273 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352503 120273 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10259525 15619 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15619 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987614 168573 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL435792 168573 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44321823 206219 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 696 13 4 8 6.1 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL86617 206219 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 696 13 4 8 6.1 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
19939753 203754 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67921 203754 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10100951 115044 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 115044 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44371045 119811 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 4 6.0 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL348363 119811 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 4 6.0 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
10344854 57605 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL1668009 57605 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O 10.1016/j.bmc.2010.10.043
10053595 103116 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 562 10 2 8 4.8 CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL307756 103116 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 562 10 2 8 4.8 CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311638 102925 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 613 18 1 8 6.7 CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306186 102925 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 613 18 1 8 6.7 CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303230 200647 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59957 200647 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80554-0
44303232 202715 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 434 8 1 6 4.8 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl 10.1016/S0960-894X(01)80554-0
CHEMBL61754 202715 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 434 8 1 6 4.8 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl 10.1016/S0960-894X(01)80554-0
44311636 204129 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 549 9 2 9 3.8 CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70389 204129 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 549 9 2 9 3.8 CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222103 204539 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 678 12 2 9 5.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72819 204539 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 678 12 2 9 5.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(00)80076-1
44376746 119859 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 568 16 2 7 5.9 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL348758 119859 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 568 16 2 7 5.9 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
44303230 200647 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL59957 200647 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
11764669 66820 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL18606 66820 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10233056 107159 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 637 10 1 8 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 10.1021/jm00043a020
CHEMBL316297 107159 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 637 10 1 8 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 10.1021/jm00043a020
10009478 112472 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1021/jm00043a020
CHEMBL329858 112472 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1021/jm00043a020
10032361 112726 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 10.1021/jm00043a020
CHEMBL330463 112726 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 10.1021/jm00043a020
10100723 207448 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 646 9 1 7 6.1 CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL94176 207448 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 646 9 1 7 6.1 CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
44303230 200647 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL59957 200647 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
11741658 18813 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 399 4 0 3 4.3 COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL127844 18813 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 399 4 0 3 4.3 COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
108185 1614 78 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
586 1614 78 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
CHEMBL907 1614 78 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
1610 2347 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
3941 2347 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
3961 2347 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
590 2347 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
CHEMBL191 2347 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
DB00678 2347 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
183134 204844 17 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00050a002
CHEMBL7550 204844 17 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00050a002
44475943 188708 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1508 12 8 32 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL504492 188708 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1508 12 8 32 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
44309703 172554 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL448476 172554 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
10417031 107386 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 669 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 10.1021/jm00043a020
CHEMBL317864 107386 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 669 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 10.1021/jm00043a020
9986951 207767 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 10.1021/jm00043a020
CHEMBL95955 207767 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 10.1021/jm00043a020
10416422 207999 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 620 9 1 7 5.8 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97295 207999 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 620 9 1 7 5.8 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10416836 107904 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 651 11 1 8 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm00043a020
CHEMBL319313 107904 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 651 11 1 8 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm00043a020
9888876 48990 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15606 48990 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(95)00185-V
73353934 92622 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435824 92622 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
10372093 112762 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
CHEMBL330533 112762 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
44376822 120053 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 565 10 1 7 5.5 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350493 120053 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 565 10 1 7 5.5 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
44274823 99075 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL280526 99075 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
9830839 106931 0 None - 2 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1021/jm00043a020
CHEMBL314812 106931 0 None - 2 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1021/jm00043a020
44379183 120815 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 571 10 1 6 6.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL355708 120815 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 571 10 1 6 6.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1016/S0960-894X(01)81125-2
11758341 117283 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 603 13 1 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 10.1021/jm00019a005
CHEMBL339544 117283 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 603 13 1 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 10.1021/jm00019a005
10326942 112394 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 10.1021/jm00043a020
CHEMBL329693 112394 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 10.1021/jm00043a020
10100074 112560 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 9 1 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL330007 112560 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 9 1 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1021/jm00043a020
44379184 57449 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 602 14 2 7 5.9 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL165541 57449 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 602 14 2 7 5.9 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1016/S0960-894X(01)81125-2
44323351 107020 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315401 107020 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10394829 119360 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344387 119360 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10485202 119420 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344811 119420 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9873751 96420 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 614 12 1 8 5.9 CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL261981 96420 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 614 12 1 8 5.9 CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323290 106900 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 587 10 1 9 5.6 CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL314603 106900 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 587 10 1 9 5.6 CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44381431 58501 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 578 11 1 9 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168346 58501 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 578 11 1 9 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10078452 107278 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1021/jm00043a020
CHEMBL317061 107278 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1021/jm00043a020
44377123 119975 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 481 10 2 6 3.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349856 119975 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 481 10 2 6 3.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
10391038 116932 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 494 13 0 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1021/jm00019a005
CHEMBL338514 116932 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 494 13 0 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1021/jm00019a005
44309701 103186 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 609 11 2 7 6.3 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL308238 103186 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 609 11 2 7 6.3 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
15230312 48914 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155987 48914 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
164620345 186213 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4873167 186213 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10054324 98353 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL275160 98353 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
9908300 15546 0 None - 0 Rat 4.2 pIC50 = 4.2 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 387 8 2 5 3.9 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1021/jm00053a013
CHEMBL12190 15546 0 None - 0 Rat 4.2 pIC50 = 4.2 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 387 8 2 5 3.9 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1021/jm00053a013
73357016 92623 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 503 8 2 4 7.0 CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435825 92623 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 503 8 2 4 7.0 CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL408773 212731 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 10.1021/jm00065a013
10462933 16882 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16882 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9850834 154662 17 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
CHEMBL39959 154662 17 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
9874508 204680 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 204680 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44210586 59012 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169221 59012 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10101690 116861 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116861 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395394 31880 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL140708 31880 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44314780 103078 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 103078 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10010207 30195 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139041 30195 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44315180 102896 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102896 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
19763341 61985 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 448 8 1 6 5.2 CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00137a004
CHEMBL177435 61985 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 448 8 1 6 5.2 CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00137a004
5311345 3021 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
597 3021 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
CHEMBL321820 3021 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
5311345 3021 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
597 3021 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
CHEMBL321820 3021 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
9804437 118065 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 463 6 1 3 5.6 O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340467 118065 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 463 6 1 3 5.6 O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
9915892 103618 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308703 103618 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
10417351 207958 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL97075 207958 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 10.1021/jm00043a020
9895984 204749 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
CHEMBL74476 204749 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
9915892 103618 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL308703 103618 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
19385644 98751 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 519 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 10.1016/0960-894X(95)00185-V
CHEMBL278061 98751 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 519 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 10.1016/0960-894X(95)00185-V
44311429 204616 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 649 11 1 8 6.8 CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL73369 204616 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 649 11 1 8 6.8 CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10318033 118273 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 387 4 2 3 3.6 O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340933 118273 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 387 4 2 3 3.6 O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311342 102181 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 611 12 3 7 5.9 CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL302760 102181 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 611 12 3 7 5.9 CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222094 102974 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 596 10 2 8 5.4 CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306489 102974 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 596 10 2 8 5.4 CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222101 158562 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 642 12 2 9 4.2 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL409170 158562 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 642 12 2 9 4.2 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(00)80076-1
44311688 104196 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 554 10 2 8 3.5 CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309820 104196 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 554 10 2 8 3.5 CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
14952909 148075 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O 10.1021/jm00108a043
CHEMBL39349 148075 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O 10.1021/jm00108a043
73357018 92632 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435834 92632 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
19385598 98862 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 6 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 10.1016/0960-894X(95)00185-V
CHEMBL278955 98862 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 6 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 10.1016/0960-894X(95)00185-V
44379291 120516 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 702 15 2 8 7.5 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL354535 120516 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 702 15 2 8 7.5 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)81125-2
14952916 100146 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 10.1021/jm00108a043
CHEMBL287762 100146 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 10.1021/jm00108a043
44384872 59995 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 575 9 3 7 4.4 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/0960-894X(96)00116-3
CHEMBL173455 59995 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 575 9 3 7 4.4 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/0960-894X(96)00116-3
CHEMBL440063 213857 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44315349 60390 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60390 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315350 105218 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 105218 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10259334 208038 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 13 1 10 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00043a020
CHEMBL97500 208038 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 13 1 10 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00043a020
114899 3020 15 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
596 3020 15 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
CHEMBL1188080 3020 15 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
5311348 100673 4 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm9504722
CHEMBL292277 100673 4 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm9504722
44379086 56578 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 543 9 1 6 5.4 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164174 56578 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 543 9 1 6 5.4 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44311074 104900 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL311253 104900 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9938088 102481 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1016/S0960-894X(01)80554-0
CHEMBL304022 102481 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1016/S0960-894X(01)80554-0
9851889 102074 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL302102 102074 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44303883 202902 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 634 11 1 3 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62744 202902 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 634 11 1 3 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9938088 102481 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
CHEMBL304022 102481 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
44382994 96904 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 933 25 7 10 5.8 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 10.1016/S0960-894X(00)80690-3
CHEMBL265790 96904 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 933 25 7 10 5.8 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 10.1016/S0960-894X(00)80690-3
CHEMBL384125 212317 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44381657 59058 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169488 59058 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10372550 164516 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 164516 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314823 161886 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161886 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
44314822 102949 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102949 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44303885 202903 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 538 12 1 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62754 202903 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 538 12 1 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10413312 117311 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 1 3 5.8 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL339706 117311 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 1 3 5.8 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
10344278 118183 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 118183 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44323559 207011 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 628 10 1 9 4.9 CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL91465 207011 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 628 10 1 9 4.9 CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44311451 104102 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 576 10 2 8 5.1 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309367 104102 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 576 10 2 8 5.1 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
18655106 200469 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)81007-6
CHEMBL59854 200469 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)81007-6
15296723 48865 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 7 1 4 5.2 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155938 48865 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 7 1 4 5.2 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 10.1016/S0960-894X(01)81122-7
14403498 101031 3 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm9504722
CHEMBL294558 101031 3 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm9504722
164612059 184501 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1123 30 14 12 1.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4847398 184501 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1123 30 14 12 1.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
44303614 200667 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 478 8 1 6 4.9 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
CHEMBL59974 200667 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 478 8 1 6 4.9 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
15222070 102297 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 9 2 9 3.8 CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL303426 102297 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 9 2 9 3.8 CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311648 204527 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 11 2 9 4.5 CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72721 204527 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 11 2 9 4.5 CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
10349256 111456 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 647 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 10.1021/jm00043a020
CHEMBL327569 111456 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 647 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 10.1021/jm00043a020
10461595 208120 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 10.1021/jm00043a020
CHEMBL97964 208120 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 10.1021/jm00043a020
10254358 117495 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 475 6 0 3 5.5 COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340018 117495 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 475 6 0 3 5.5 COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311472 103792 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 669 14 3 8 5.7 CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308943 103792 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 669 14 3 8 5.7 CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44377199 57419 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 531 10 2 6 4.9 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL165349 57419 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 531 10 2 6 4.9 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
73353933 92619 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 554 11 2 6 5.2 CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435821 92619 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 554 11 2 6 5.2 CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
10078132 107251 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 10.1021/jm00043a020
CHEMBL316904 107251 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 10.1021/jm00043a020
10078048 106880 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 12 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1021/jm00043a020
CHEMBL314514 106880 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 12 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1021/jm00043a020
10411441 51790 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL15850 51790 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
15230316 120092 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 522 7 1 6 5.3 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL350875 120092 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 522 7 1 6 5.3 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
44348259 16032 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 575 12 1 5 8.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 10.1021/jm00075a033
CHEMBL122367 16032 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 575 12 1 5 8.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 10.1021/jm00075a033
1610 2347 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3941 2347 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3961 2347 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
590 2347 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
CHEMBL191 2347 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
DB00678 2347 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
1610 2347 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
3941 2347 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
3961 2347 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
590 2347 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
CHEMBL191 2347 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
DB00678 2347 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
10393837 167944 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 602 10 1 8 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 10.1021/jm00043a020
CHEMBL431619 167944 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 602 10 1 8 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 10.1021/jm00043a020
44211672 158206 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 706 4 1 8 7.4 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL408799 158206 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 706 4 1 8 7.4 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
9892451 48740 23 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/acs.jmedchem.9b01780
CHEMBL155836 48740 23 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/acs.jmedchem.9b01780
15296726 51871 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 2 5 5.1 COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL158557 51871 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 2 5 5.1 COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
18950598 15542 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C 10.1021/jm00075a033
CHEMBL121891 15542 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C 10.1021/jm00075a033
10483888 111455 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1021/jm00043a020
CHEMBL327563 111455 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1021/jm00043a020
18950607 50418 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 489 9 1 5 6.2 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15729 50418 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 489 9 1 5 6.2 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
9933755 55046 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 456 9 1 5 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL16165 55046 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 456 9 1 5 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
73355475 92625 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 9 2 4 6.9 CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435827 92625 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 9 2 4 6.9 CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
9807029 203104 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL63998 203104 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1016/S0960-894X(01)80554-0
9807029 203104 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1021/jm9504722
CHEMBL63998 203104 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1021/jm9504722
73347892 92621 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435823 92621 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
25135102 188870 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1495 12 10 32 3.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL507053 188870 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1495 12 10 32 3.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
10349801 107938 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL319353 107938 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 10.1021/jm00043a020
19385586 49726 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 479 8 1 6 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
CHEMBL15669 49726 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 479 8 1 6 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
10414470 17129 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00019a005
CHEMBL125542 17129 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00019a005
44322176 206677 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 646 13 3 11 4.4 CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89463 206677 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 646 13 3 11 4.4 CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381622 59021 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169279 59021 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
44315078 204756 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 204756 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19102815 207878 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL96554 207878 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
44321775 106999 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 588 13 4 8 4.4 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315275 106999 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 588 13 4 8 4.4 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
10439858 16861 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16861 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
5311345 3021 46 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
597 3021 46 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
CHEMBL321820 3021 46 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
44381670 120484 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 657 11 3 9 6.0 CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354298 120484 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 657 11 3 9 6.0 CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 10.1016/S0960-894X(01)81126-4
44315282 96624 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96624 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
10344278 118183 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 118183 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44303211 100598 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomesCompound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomes
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
CHEMBL291803 100598 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomesCompound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomes
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
44303404 199706 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59331 199706 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL264450 210619 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CCSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44311498 102930 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 580 10 2 8 4.9 CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306216 102930 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 580 10 2 8 4.9 CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222092 103824 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 564 10 2 10 3.5 CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309165 103824 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 564 10 2 10 3.5 CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44379182 58122 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 593 10 1 6 6.7 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167662 58122 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 593 10 1 6 6.7 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
9961192 11366 43 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
CHEMBL1179743 11366 43 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
CHEMBL97688 11366 43 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
10417102 207446 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 10.1021/jm00043a020
CHEMBL94145 207446 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 10.1021/jm00043a020
44303211 100598 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1021/jm9504722
CHEMBL291803 100598 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1021/jm9504722
18950608 15671 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 10.1021/jm00075a033
CHEMBL122224 15671 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 10.1021/jm00075a033
44311568 98184 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 13 2 8 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL273992 98184 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 13 2 8 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44270367 163223 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 505 9 1 5 6.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 10.1016/0960-894X(95)00185-V
CHEMBL418354 163223 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 505 9 1 5 6.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 10.1016/0960-894X(95)00185-V
44377111 119884 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 495 10 1 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349020 119884 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 495 10 1 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
44210830 57483 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 461 6 1 6 5.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 10.1016/S0960-894X(01)80193-1
CHEMBL165850 57483 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 461 6 1 6 5.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 10.1016/S0960-894X(01)80193-1
10054708 107154 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 10.1021/jm00043a020
CHEMBL316273 107154 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 10.1021/jm00043a020
44304163 202785 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 496 17 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62157 202785 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 496 17 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10350378 208199 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 10.1021/jm00043a020
CHEMBL98453 208199 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 10.1021/jm00043a020
44574325 188750 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1521 12 8 32 4.8 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL505204 188750 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1521 12 8 32 4.8 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL413034 213048 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
9874086 109113 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 10.1021/jm00043a020
CHEMBL321367 109113 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 10.1021/jm00043a020
19939756 5038 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL105199 5038 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
10349845 11362 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
CHEMBL1179731 11362 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
CHEMBL97271 11362 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
164627947 186385 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4875696 186385 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10426066 100508 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 318 7 1 3 4.0 CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL291114 100508 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 318 7 1 3 4.0 CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
44311454 102945 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL306340 102945 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311436 204188 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 8 8.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70793 204188 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 8 8.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44303420 201743 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60661 201743 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 10.1016/S0960-894X(01)80554-0
44321804 105980 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 690 13 4 8 5.7 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL313073 105980 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 690 13 4 8 5.7 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL406290 212603 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
15292111 204745 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 204745 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315304 205010 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 205010 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
15230313 48614 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 446 6 1 4 4.3 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155728 48614 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 446 6 1 4 4.3 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
15292112 102948 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102948 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10368357 117271 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 7 1 3 5.5 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL339485 117271 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 7 1 3 5.5 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
10344278 118183 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 118183 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311739 102607 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 14 2 7 6.2 CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
CHEMBL304137 102607 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 14 2 7 6.2 CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
44311662 102681 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 624 17 2 7 5.8 CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC 10.1016/S0960-894X(00)80076-1
CHEMBL304620 102681 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 624 17 2 7 5.8 CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC 10.1016/S0960-894X(00)80076-1
44311650 103201 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 674 14 2 10 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308361 103201 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 674 14 2 10 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
14952904 100164 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 396 9 2 5 4.8 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O 10.1021/jm00108a043
CHEMBL287936 100164 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 396 9 2 5 4.8 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O 10.1021/jm00108a043
44309704 204278 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL71253 204278 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
44300798 198955 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 558 8 1 7 6.1 CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL58499 198955 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 558 8 1 7 6.1 CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
9805344 99040 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 483 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL280290 99040 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 483 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
10372718 108557 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl 10.1021/jm00043a020
CHEMBL320222 108557 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl 10.1021/jm00043a020
9809280 204972 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL76525 204972 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL80370 204972 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
9809280 204972 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
CHEMBL76525 204972 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
CHEMBL80370 204972 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
19385623 50435 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15730 50435 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 10.1016/0960-894X(95)00185-V
44335530 107509 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL318605 107509 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
44323292 163802 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.2 CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL420607 163802 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.2 CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323363 111606 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 558 10 2 8 4.5 CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328340 111606 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 558 10 2 8 4.5 CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379185 57554 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 603 13 2 7 5.6 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL166428 57554 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 603 13 2 7 5.6 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 10.1016/S0960-894X(01)81125-2
19742811 57421 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL165354 57421 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
56661223 63252 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791308 63252 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL2392353 210414 6 None - 1 Human 10.0 pKi = 10.0 Binding
Binding affinity to human AT2 receptor by radioligand displacement assayBinding affinity to human AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
10079601 212531 14 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1021/ml500278g
CHEMBL404594 212531 14 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1021/ml500278g
10079601 212531 14 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL404594 212531 14 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL938 215907 28 None -1 2 Human 9.8 pKi = 9.8 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm8007618
CHEMBL216061 209316 15 None -1 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
16133225 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
172198 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
2504 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
45266664 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
5272 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
CHEMBL408403 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
DB11842 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
16133225 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
172198 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
2504 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
45266664 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
5272 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
CHEMBL408403 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
DB11842 419 52 None 1 4 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
16133225 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
172198 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
2504 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
45266664 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
5272 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
CHEMBL408403 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
DB11842 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
16133225 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
172198 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
2504 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
45266664 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
5272 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
CHEMBL408403 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
DB11842 419 52 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
56661223 63252 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791308 63252 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
16133225 419 52 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
172198 419 52 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
2504 419 52 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
45266664 419 52 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
5272 419 52 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
CHEMBL408403 419 52 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
DB11842 419 52 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
CHEMBL938 215907 28 None -1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/ml500278g
CHEMBL938 215907 28 None -1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmcl.2015.10.084
6918 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
9804984 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
CHEMBL189568 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
6918 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
6918 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
9804984 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
9804984 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
CHEMBL189568 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
CHEMBL189568 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
6918 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
9804984 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
CHEMBL189568 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
6918 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
9804984 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
CHEMBL189568 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
11317806 123642 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 489 10 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 10.1021/jm049715t
CHEMBL361927 123642 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 489 10 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 10.1021/jm049715t
11994291 80728 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 485 12 1 7 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL215160 80728 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 485 12 1 7 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11994289 82477 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217673 82477 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
16133225 419 52 None 1 4 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
172198 419 52 None 1 4 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
2504 419 52 None 1 4 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
45266664 419 52 None 1 4 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
5272 419 52 None 1 4 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
CHEMBL408403 419 52 None 1 4 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
DB11842 419 52 None 1 4 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
CHEMBL404996 212539 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None CCSC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm030921v
CHEMBL3350599 211481 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
11994289 82477 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL217673 82477 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/acs.jmedchem.5b00982
11994289 82477 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL217673 82477 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL268815 210766 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm051222g
10463891 96914 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL265881 96914 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL268815 210766 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm0491492
CHEMBL424755 213324 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)O 10.1021/jm0613469
44398242 67216 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
CHEMBL187880 67216 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
10163396 81578 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 489 12 1 7 4.5 CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216250 81578 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 489 12 1 7 4.5 CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL5286105 194331 0 None - 1 Rat 9.0 pKi = 9 Binding
Displacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting methodDisplacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting method
ChEMBL 1073 26 13 14 -1.2 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@]1(Cc2ccc(O)cc2)CC(=O)N2[C@H]1SC[C@H]2C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2022.128983
168283461 190983 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 10 1 8 4.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5186237 190983 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 10 1 8 4.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
16133225 419 52 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
172198 419 52 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
2504 419 52 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
45266664 419 52 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
5272 419 52 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
CHEMBL408403 419 52 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
DB11842 419 52 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
CHEMBL5274111 193795 0 None -1 2 Rat 8.9 pKi = 8.9 Binding
Displacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting methodDisplacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting method
ChEMBL 1060 30 14 13 -0.7 CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2022.128983
168273584 190213 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 503 8 1 10 4.2 CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5174659 190213 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 503 8 1 10 4.2 CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL268815 210766 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm049651m
9850834 154662 17 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL39959 154662 17 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
16087342 141713 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL385706 141713 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
11564291 167094 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1008 26 12 12 -0.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL428986 167094 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1008 26 12 12 -0.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
10160913 141807 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386269 141807 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11766283 71580 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 909 23 11 11 -0.2 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL196316 71580 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 909 23 11 11 -0.2 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
168270996 190059 0 None 64 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 533 11 1 6 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5172324 190059 0 None 64 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 533 11 1 6 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168291545 191990 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 597 10 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 10.1016/j.bmc.2022.116804
CHEMBL5201369 191990 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 597 10 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 10.1016/j.bmc.2022.116804
162660565 181322 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 9 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL4762752 181322 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 9 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL426885 213351 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)O 10.1021/jm0613469
56657702 63253 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791309 63253 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
168290795 191947 0 None 33 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 559 11 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5200734 191947 0 None 33 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 559 11 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168292515 192039 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 10.1016/j.bmc.2022.116804
CHEMBL5202149 192039 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 10.1016/j.bmc.2022.116804
118725967 117198 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
CHEMBL3394207 117198 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
118725967 117198 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
CHEMBL3394207 117198 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
168274956 190338 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 10 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5176607 190338 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 10 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10227337 81656 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216361 81656 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168296606 192448 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 587 11 1 6 8.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5208437 192448 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 587 11 1 6 8.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145963801 164061 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4209214 164061 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
11365721 98667 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 640 13 1 10 6.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1021/jm031031i
CHEMBL277388 98667 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 640 13 1 10 6.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1021/jm031031i
168287840 191306 0 None 32 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 12 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5191241 191306 0 None 32 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 12 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145978135 163889 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 9 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4207027 163889 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 9 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 10.1016/j.bmcl.2017.11.042
168295859 192285 0 None -50 2 Human 5.9 pKi = 5.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 569 11 1 9 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205969 192285 0 None -50 2 Human 5.9 pKi = 5.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 569 11 1 9 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
168288075 191662 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 595 12 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5196244 191662 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 595 12 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
11994292 81986 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 471 10 1 7 4.6 CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216515 81986 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 471 10 1 7 4.6 CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168285844 191569 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 8 1 8 4.2 CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5194914 191569 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 8 1 8 4.2 CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
44420775 137884 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 315 7 2 4 2.2 CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1021/jm0613469
CHEMBL376286 137884 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 315 7 2 4 2.2 CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1021/jm0613469
145965121 164426 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4213607 164426 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1016/j.bmcl.2017.11.042
11296725 100374 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 652 13 2 9 6.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289803 100374 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 652 13 2 9 6.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 10.1021/jm031031i
9830680 100643 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
CHEMBL292150 100643 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
162657895 181059 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 12 1 8 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4759641 181059 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 12 1 8 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 10.1016/j.bmc.2020.115859
56964910 77444 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/ml500278g
CHEMBL2086892 77444 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/ml500278g
56964910 77444 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
CHEMBL2086892 77444 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
162675267 183357 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 8 1 7 4.8 CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4797684 183357 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 8 1 7 4.8 CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
11764788 100858 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
CHEMBL293501 100858 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
158303357 192232 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 532 10 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205106 192232 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 532 10 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
166492461 191812 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 474 8 1 8 4.2 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5198482 191812 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 474 8 1 8 4.2 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
145977406 163848 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 487 8 1 7 5.2 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4206507 163848 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 487 8 1 7 5.2 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 10.1016/j.bmcl.2017.11.042
73213176 104701 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 454 9 2 6 2.6 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105392 104701 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 454 9 2 6 2.6 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2013.12.040
11995658 82138 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 364 6 1 6 4.0 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 10.1021/jm0606185
CHEMBL216746 82138 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 364 6 1 6 4.0 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 10.1021/jm0606185
168274734 190666 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 12 1 6 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5181652 190666 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 12 1 6 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
166492455 191409 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 7 1 8 4.4 CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5192639 191409 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 7 1 8 4.4 CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
3936 2210 35 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
6603900 2210 35 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
CHEMBL288174 2210 35 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
11994290 80400 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 441 9 1 6 4.4 CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 10.1021/jm0606185
CHEMBL214525 80400 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 441 9 1 6 4.4 CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 10.1021/jm0606185
CHEMBL268815 210766 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm030921v
10031067 100352 4 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL289614 100352 4 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL216331 209323 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm049651m
56657702 63253 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791309 63253 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
168277309 190228 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 448 8 1 8 3.7 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5174923 190228 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 448 8 1 8 3.7 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
3936 2210 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
6603900 2210 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
CHEMBL288174 2210 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
44400670 158892 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 993 23 12 13 -0.7 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL409528 158892 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 993 23 12 13 -0.7 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
3936 2210 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
6603900 2210 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
CHEMBL288174 2210 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
168277868 190477 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 10 1 8 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5178914 190477 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 10 1 8 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
145978497 163654 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 10 1 7 5.3 CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4204342 163654 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 10 1 7 5.3 CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145972310 164567 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 9 1 6 4.6 CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4215292 164567 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 9 1 6 4.6 CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
45102601 169571 12 None -1995 2 Human 5.6 pKi = 5.6 Binding
Displacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
CHEMBL4435800 169571 12 None -1995 2 Human 5.6 pKi = 5.6 Binding
Displacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
162651258 180335 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 13 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 10.1016/j.bmc.2020.115859
CHEMBL4751226 180335 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 13 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 10.1016/j.bmc.2020.115859
166492466 191942 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 8 1 8 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5200682 191942 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 8 1 8 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
56964910 77444 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
CHEMBL2086892 77444 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
56964910 77444 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL2086892 77444 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145967796 164833 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4218765 164833 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1016/j.bmcl.2017.11.042
67132863 77447 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 503 11 1 8 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
CHEMBL2086910 77447 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 503 11 1 8 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
145976243 163526 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 11 1 6 5.2 CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4202730 163526 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 11 1 6 5.2 CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
163408877 190699 3 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 490 7 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5182186 190699 3 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 490 7 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
168277087 190486 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 505 10 1 6 5.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5179052 190486 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 505 10 1 6 5.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145969149 164769 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 9 1 7 4.7 CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4217991 164769 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 9 1 7 4.7 CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
73213178 104702 0 None - 1 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 483 10 3 6 2.4 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105394 104702 0 None - 1 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 483 10 3 6 2.4 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2013.12.040
10057017 161827 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm030921v
CHEMBL414478 161827 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm030921v
10057017 161827 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm0491492
CHEMBL414478 161827 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm0491492
168272246 190492 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 477 10 1 8 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5179119 190492 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 477 10 1 8 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 10.1016/j.bmc.2022.116790
10196520 67644 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 553 11 1 7 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1021/jm049715t
CHEMBL190577 67644 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 553 11 1 7 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1021/jm049715t
6918 1028 35 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
9804984 1028 35 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
CHEMBL189568 1028 35 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
44398381 67606 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
CHEMBL190286 67606 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
CHEMBL5286767 194355 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Displacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting methodDisplacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting method
ChEMBL 1073 26 13 14 -1.2 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@]1(Cc2ccc(O)cc2)CC(=O)N2[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CS[C@@H]21 10.1016/j.bmcl.2022.128983
10054827 164138 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
CHEMBL42101 164138 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
145978684 163561 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 445 9 1 6 4.5 CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4203099 163561 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 445 9 1 6 4.5 CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145974498 164726 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4217484 164726 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
168287782 191824 0 None 22 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 545 11 1 6 6.8 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5198739 191824 0 None 22 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 545 11 1 6 6.8 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10277322 141788 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386172 141788 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11274375 100462 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 804 16 1 9 9.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL290708 100462 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 804 16 1 9 9.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
163409135 190183 3 None -37 2 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 623 11 1 9 6.5 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmc.2022.116790
CHEMBL5174180 190183 3 None -37 2 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 623 11 1 9 6.5 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmc.2022.116790
11216369 100371 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289775 100371 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
11994293 82301 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.9 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217208 82301 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.9 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
145976532 163606 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 443 8 1 6 4.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4203624 163606 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 443 8 1 6 4.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 10.1016/j.bmcl.2017.11.042
168279676 191129 0 None 11 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5188126 191129 0 None 11 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
166492421 190625 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 545 11 1 10 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5181087 190625 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 545 11 1 10 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
10116410 141519 1 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL384577 141519 1 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11445913 133622 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 908 19 10 12 0.3 C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL371395 133622 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 908 19 10 12 0.3 C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
16124929 83445 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 2 4 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 10.1021/jm0613469
CHEMBL219840 83445 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 2 4 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 10.1021/jm0613469
166492441 191505 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 504 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5193845 191505 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 504 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
162666037 182312 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 14 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 10.1016/j.bmc.2020.115859
CHEMBL4784233 182312 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 14 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 10.1016/j.bmc.2020.115859
8374 2922 42 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
9937291 2922 42 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL34124 2922 42 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
DB16266 2922 42 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
145964638 164383 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 11 1 7 5.5 CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4213069 164383 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 11 1 7 5.5 CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
168274602 190376 0 None 97 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 11 1 6 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5177359 190376 0 None 97 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 11 1 6 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
9806878 127520 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 525 10 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1021/jm049715t
CHEMBL366210 127520 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 525 10 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1021/jm049715t
11995655 141497 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 10 1 6 5.0 CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL384462 141497 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 10 1 6 5.0 CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
44212339 205036 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 438 7 1 6 4.9 CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL77029 205036 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 438 7 1 6 4.9 CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
168297670 192378 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 615 10 1 6 7.8 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
CHEMBL5207511 192378 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 615 10 1 6 7.8 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
11181498 100509 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 680 14 1 9 6.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL291124 100509 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 680 14 1 9 6.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
16087341 96881 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL265613 96881 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
16124928 83444 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 3 3 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 10.1021/jm0613469
CHEMBL219839 83444 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 3 3 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 10.1021/jm0613469
11180576 100312 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 566 11 1 7 6.6 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL289306 100312 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 566 11 1 7 6.6 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
145972980 164494 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 433 7 1 7 3.9 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4214477 164494 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 433 7 1 7 3.9 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145972801 164602 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4215828 164602 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
166492420 192258 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 559 11 1 10 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205556 192258 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 559 11 1 10 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
11722069 70567 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 895 22 11 11 0.1 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL194864 70567 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 895 22 11 11 0.1 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
73213175 104700 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 397 8 2 6 3.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 10.1016/j.bmcl.2013.12.040
CHEMBL3105391 104700 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 397 8 2 6 3.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 10.1016/j.bmcl.2013.12.040
166492452 190775 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 502 11 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5183386 190775 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 502 11 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
145966800 164026 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 5.1 CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4208670 164026 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 5.1 CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
11366289 168013 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 784 18 1 9 9.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL432095 168013 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 784 18 1 9 9.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 10.1021/jm031031i
168283187 191217 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 639 11 1 6 8.4 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5189691 191217 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 639 11 1 6 8.4 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10396262 115434 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1022 27 12 12 0.3 CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
CHEMBL3350600 115434 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1022 27 12 12 0.3 CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
16125001 106431 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
CHEMBL3105395 106431 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
CHEMBL3139603 106431 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
11331641 100302 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289211 100302 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
67133138 77448 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 12 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 10.1016/j.bmc.2020.115859
CHEMBL2086911 77448 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 12 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 10.1016/j.bmc.2020.115859
10742620 57602 0 None -16 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 460 7 2 6 5.1 CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1668003 57602 0 None -16 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 460 7 2 6 5.1 CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
163409136 190902 3 None -18 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 583 11 1 9 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5185088 190902 3 None -18 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 583 11 1 9 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
145965943 164204 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4210874 164204 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
131590 20703 44 None -16 3 Human 6.3 pKi = 6.3 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9504722
CHEMBL130896 20703 44 None -16 3 Human 6.3 pKi = 6.3 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9504722
10276878 80422 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 11 1 6 5.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL214592 80422 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 11 1 6 5.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
10140383 82390 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 11 1 7 5.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217249 82390 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 11 1 7 5.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168271055 189938 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 588 11 1 8 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5170220 189938 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 588 11 1 8 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168272577 190355 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 10 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5176951 190355 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 10 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168277414 190463 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 517 8 1 10 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5178751 190463 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 517 8 1 10 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
166492465 190547 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 11 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5179875 190547 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 11 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
162650706 180038 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 515 10 1 8 5.0 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL4747530 180038 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 515 10 1 8 5.0 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
16087340 165937 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 912 21 10 11 1.2 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL425077 165937 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 912 21 10 11 1.2 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
168292360 191877 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 581 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5199606 191877 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 581 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168278021 190193 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
CHEMBL5174301 190193 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
11994156 82129 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 10 1 7 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216688 82129 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 10 1 7 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
162663560 181938 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 11 1 8 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4779819 181938 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 11 1 8 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
56678310 63251 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1034 25 11 12 1.0 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm030921v
CHEMBL1791259 63251 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1034 25 11 12 1.0 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm030921v
10140382 141876 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1021/jm0606185
CHEMBL386671 141876 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1021/jm0606185
9891811 119742 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL347703 119742 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL4524047 119742 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
10289461 67768 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 526 10 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 10.1021/jm049715t
CHEMBL190811 67768 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 526 10 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 10.1021/jm049715t
162663467 181952 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 9 1 8 5.4 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4779945 181952 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 9 1 8 5.4 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
11316477 68094 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 434 9 1 6 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 10.1021/jm049715t
CHEMBL191468 68094 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 434 9 1 6 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 10.1021/jm049715t
163848227 190111 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 10 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5173054 190111 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 10 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
145965035 164251 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 529 10 1 7 5.6 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4211391 164251 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 529 10 1 7 5.6 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmcl.2017.11.042
132404 119786 14 None -36 2 Human 6.1 pKi = 6.1 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 637 13 3 5 8.0 CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 10.1021/jm9504722
CHEMBL348126 119786 14 None -36 2 Human 6.1 pKi = 6.1 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 637 13 3 5 8.0 CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 10.1021/jm9504722
10161763 80727 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1021/jm0606185
CHEMBL215159 80727 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1021/jm0606185
10300357 141714 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 495 11 1 7 4.3 CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL385714 141714 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 495 11 1 7 4.3 CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
4189 206922 96 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 206922 96 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 206922 96 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10182998 141884 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.7 CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386718 141884 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.7 CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
132840 105489 22 None -3311 3 Rat 4.1 pKi = 4.1 Binding
In vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenalIn vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenal
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL312104 105489 22 None -3311 3 Rat 4.1 pKi = 4.1 Binding
In vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenalIn vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenal
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
11239632 100151 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 748 15 1 10 8.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL287829 100151 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 748 15 1 10 8.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 10.1021/jm031031i
118725969 117199 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
CHEMBL3394209 117199 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
11251114 159186 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 714 14 2 9 7.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL409843 159186 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 714 14 2 9 7.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
73213179 104705 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 511 10 3 6 3.0 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C 10.1016/j.bmcl.2013.12.040
CHEMBL3105465 104705 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 511 10 3 6 3.0 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C 10.1016/j.bmcl.2013.12.040
10205901 82513 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 11 1 8 4.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217752 82513 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 11 1 8 4.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168294859 192276 0 None 19 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 13 1 6 7.3 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5205769 192276 0 None 19 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 13 1 6 7.3 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
44400615 156617 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1007 22 11 13 0.4 CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL406907 156617 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1007 22 11 13 0.4 CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
162670036 182656 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 517 8 1 8 5.0 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4788892 182656 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 517 8 1 8 5.0 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
168275495 190471 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 519 10 1 6 6.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5178838 190471 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 519 10 1 6 6.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
11672486 98511 0 None 3 2 Human 8.0 pKi = 8.0 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 994 25 12 12 0.3 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL276163 98511 0 None 3 2 Human 8.0 pKi = 8.0 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 994 25 12 12 0.3 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
166492458 191574 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 516 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5195051 191574 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 516 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
6918 1028 35 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
9804984 1028 35 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
CHEMBL189568 1028 35 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
73213180 104706 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 499 11 3 7 2.1 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105466 104706 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 499 11 3 7 2.1 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 10.1016/j.bmcl.2013.12.040
73213252 104707 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 434 11 2 6 2.3 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC 10.1016/j.bmcl.2013.12.040
CHEMBL3105467 104707 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 434 11 2 6 2.3 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC 10.1016/j.bmcl.2013.12.040
1610 2347 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2347 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2347 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2347 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2347 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2347 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
1037 1578 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
3940 1578 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
5281037 1578 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
588 1578 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
CHEMBL813 1578 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
DB00876 1578 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
2583 3776 118 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
592 3776 118 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
65999 3776 118 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
CHEMBL1017 3776 118 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
DB00966 3776 118 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
16133225 419 52 None 1 4 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
172198 419 52 None 1 4 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
2504 419 52 None 1 4 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
45266664 419 52 None 1 4 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
5272 419 52 None 1 4 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
CHEMBL408403 419 52 None 1 4 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
DB11842 419 52 None 1 4 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
16133225 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
16133225 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
172198 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
172198 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
2504 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
2504 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
45266664 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
45266664 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
5272 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
5272 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
CHEMBL408403 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL408403 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
DB11842 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
DB11842 419 52 None 1 4 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
44299731 420 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
44299731 420 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
585 420 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
585 420 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
CHEMBL56448 420 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL56448 420 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
123794 893 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
123794 893 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
3944 893 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
3944 893 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
594 893 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
594 893 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL1885579 893 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
CHEMBL1885579 893 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
5311345 3021 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
5311345 3021 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
597 3021 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
597 3021 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
CHEMBL321820 3021 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
CHEMBL321820 3021 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
595 2996 0 None - 1 Rat 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2194459
4189 206922 96 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 206922 96 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 206922 96 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
36736 3474 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
598 3474 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
6324663 3474 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
CHEMBL356431 3474 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
6893 2867 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18207609
9987879 2867 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18207609
6894 418 0 None -1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
91691124 418 0 None -1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
6918 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
9804984 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
CHEMBL189568 1028 35 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
11931 1065 0 None 10 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 621 10 1 8 6.7 CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
126456406 1065 0 None 10 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 621 10 1 8 6.7 CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
11930 1019 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
15780052 1019 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
CHEMBL289472 1019 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944