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Ligand source activities (1 row/activity)

Ligand Receptor Assay information Chemical information
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name
GPCRdb ID #Vendors UniProt IUPHAR Species p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
770 782 0 CCR1 CCR1 Human - = Unclassified
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
772 824 0 CCR1 CCR1 Human - = Unclassified
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
10164 828 0 CCR1 CCR1 Human - = Unclassified
UnclassifiedUnclassified
Guide to Pharmacology 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 None
25016615 828 0 CCR1 CCR1 Human - = Unclassified
UnclassifiedUnclassified
Guide to Pharmacology 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 None
93149 106479 66 CCR1 CCR1 Human 6.0 pEC50 = 6 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
CHEMBL316589 106479 66 CCR1 CCR1 Human 6.0 pEC50 = 6 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
336912 83134 20 CCR1 CCR1 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 240 2 2 4 1.8 OCc1ccc2ccc3ccc(CO)nc3c2n1 10.1021/jm301121j
CHEMBL2205802 83134 20 CCR1 CCR1 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 240 2 2 4 1.8 OCc1ccc2ccc3ccc(CO)nc3c2n1 10.1021/jm301121j
2733927 83139 80 CCR1 CCR1 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
CHEMBL2205808 83139 80 CCR1 CCR1 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
667748 83136 70 CCR1 CCR1 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
CHEMBL2205805 83136 70 CCR1 CCR1 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
20445 83137 97 CCR1 CCR1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
CHEMBL2205806 83137 97 CCR1 CCR1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
667748 83136 70 CCR1 CCR1 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
CHEMBL2205805 83136 70 CCR1 CCR1 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
15783796 83142 1 CCR1 CCR1 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
CHEMBL2205810 83142 1 CCR1 CCR1 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
602123 83135 45 CCR1 CCR1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
CHEMBL2205803 83135 45 CCR1 CCR1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
20445 83137 97 CCR1 CCR1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
CHEMBL2205806 83137 97 CCR1 CCR1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
15783796 83142 1 CCR1 CCR1 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
CHEMBL2205810 83142 1 CCR1 CCR1 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
602123 83135 45 CCR1 CCR1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
CHEMBL2205803 83135 45 CCR1 CCR1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
74265 201875 96 CCR1 CCR1 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
CHEMBL99384 201875 96 CCR1 CCR1 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
353741 71486 3 CCR1 CCR1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
CHEMBL1976682 71486 3 CCR1 CCR1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
65237 136834 88 CCR1 CCR1 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
CHEMBL375781 136834 88 CCR1 CCR1 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
74265 201875 96 CCR1 CCR1 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
CHEMBL99384 201875 96 CCR1 CCR1 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
353741 71486 3 CCR1 CCR1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
CHEMBL1976682 71486 3 CCR1 CCR1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
15664 83138 85 CCR1 CCR1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
CHEMBL2205807 83138 85 CCR1 CCR1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
65237 136834 88 CCR1 CCR1 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
CHEMBL375781 136834 88 CCR1 CCR1 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
15664 83138 85 CCR1 CCR1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
CHEMBL2205807 83138 85 CCR1 CCR1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
72791 201768 62 CCR1 CCR1 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL98682 201768 62 CCR1 CCR1 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
77865 106564 68 CCR1 CCR1 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL317115 106564 68 CCR1 CCR1 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
72791 201768 62 CCR1 CCR1 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL98682 201768 62 CCR1 CCR1 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
12041800 197070 0 CCR1 CCR1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
ChEMBL 410 7 2 4 6.4 Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1 10.1016/j.bmcl.2011.11.014
CHEMBL66165 197070 0 CCR1 CCR1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
ChEMBL 410 7 2 4 6.4 Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1 10.1016/j.bmcl.2011.11.014
77865 106564 68 CCR1 CCR1 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL317115 106564 68 CCR1 CCR1 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
1474 153597 124 CCR1 CCR1 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
CHEMBL39879 153597 124 CCR1 CCR1 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
1474 153597 124 CCR1 CCR1 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
CHEMBL39879 153597 124 CCR1 CCR1 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
14338 4120 106 CCR1 CCR1 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4120 106 CCR1 CCR1 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
14338 4120 106 CCR1 CCR1 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4120 106 CCR1 CCR1 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
12987698 83140 2 CCR1 CCR1 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
CHEMBL2205809 83140 2 CCR1 CCR1 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
14434082 83133 6 CCR1 CCR1 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
CHEMBL2205801 83133 6 CCR1 CCR1 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
14434082 83133 6 CCR1 CCR1 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
CHEMBL2205801 83133 6 CCR1 CCR1 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
12987698 83140 2 CCR1 CCR1 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
CHEMBL2205809 83140 2 CCR1 CCR1 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
1318 161142 105 CCR1 CCR1 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 c1cnc2c(c1)ccc1cccnc12 10.1021/jm301121j
CHEMBL415879 161142 105 CCR1 CCR1 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 c1cnc2c(c1)ccc1cccnc12 10.1021/jm301121j
1318 161142 105 CCR1 CCR1 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 c1cnc2c(c1)ccc1cccnc12 10.1021/jm301121j
CHEMBL415879 161142 105 CCR1 CCR1 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 c1cnc2c(c1)ccc1cccnc12 10.1021/jm301121j
70848 200216 94 CCR1 CCR1 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
CHEMBL89445 200216 94 CCR1 CCR1 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
70848 200216 94 CCR1 CCR1 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
CHEMBL89445 200216 94 CCR1 CCR1 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
72792 193310 71 CCR1 CCR1 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 193310 71 CCR1 CCR1 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
72792 193310 71 CCR1 CCR1 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 193310 71 CCR1 CCR1 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL4128926 160742 0 CCR1 CCR1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
25109291 187277 8 CCR1 CCR1 Human 10.1 pIC50 = 10.1 Binding
Displacement of radiolabeled MIP1alpha from human CCR1 receptorDisplacement of radiolabeled MIP1alpha from human CCR1 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
CHEMBL519240 187277 8 CCR1 CCR1 Human 10.1 pIC50 = 10.1 Binding
Displacement of radiolabeled MIP1alpha from human CCR1 receptorDisplacement of radiolabeled MIP1alpha from human CCR1 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
10456104 71404 0 CCR1 CCR1 Human 10.0 pIC50 = 10 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197375 71404 0 CCR1 CCR1 Human 10.0 pIC50 = 10 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
59278332 170232 0 CCR1 CCR1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4457209 170232 0 CCR1 CCR1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
59278286 170716 0 CCR1 CCR1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464625 170716 0 CCR1 CCR1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
59278286 170716 0 CCR1 CCR1 Human 9.5 pIC50 = 9.5 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464625 170716 0 CCR1 CCR1 Human 9.5 pIC50 = 9.5 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
45138759 171496 0 CCR1 CCR1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 467 7 1 7 3.6 CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4475581 171496 0 CCR1 CCR1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 467 7 1 7 3.6 CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
11744314 86686 0 CCR1 CCR1 Human 9.4 pIC50 = 9.4 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 446 6 3 6 3.2 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
CHEMBL2332935 86686 0 CCR1 CCR1 Human 9.4 pIC50 = 9.4 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 446 6 3 6 3.2 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
68959963 86684 0 CCR1 CCR1 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 432 6 2 5 3.1 CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2012.12.095
CHEMBL2332933 86684 0 CCR1 CCR1 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 432 6 2 5 3.1 CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2012.12.095
11744314 86686 0 CCR1 CCR1 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 446 6 3 6 3.2 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2012.12.095
CHEMBL2332935 86686 0 CCR1 CCR1 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 446 6 3 6 3.2 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2012.12.095
512282 716 46 CCR1 CCR1 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 716 46 CCR1 CCR1 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 716 46 CCR1 CCR1 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
10094212 86687 0 CCR1 CCR1 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 430 6 3 6 2.7 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2013.04.047
CHEMBL2332936 86687 0 CCR1 CCR1 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 430 6 3 6 2.7 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2013.04.047
10094212 86687 0 CCR1 CCR1 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 430 6 3 6 2.7 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2012.12.095
CHEMBL2332936 86687 0 CCR1 CCR1 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 430 6 3 6 2.7 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2012.12.095
72945512 103610 0 CCR1 CCR1 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 471 7 4 6 3.0 O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)NC1CC1 10.1016/j.bmcl.2013.11.062
CHEMBL3099947 103610 0 CCR1 CCR1 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 471 7 4 6 3.0 O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)NC1CC1 10.1016/j.bmcl.2013.11.062
10478859 86682 0 CCR1 CCR1 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 448 6 2 5 3.6 CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2012.12.095
CHEMBL2332931 86682 0 CCR1 CCR1 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 448 6 2 5 3.6 CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2012.12.095
25141109 129497 0 CCR1 CCR1 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 493 5 4 4 3.8 C[C@H](NC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O nan
CHEMBL3679659 129497 0 CCR1 CCR1 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 493 5 4 4 3.8 C[C@H](NC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O nan
25141109 129497 0 CCR1 CCR1 Human 9.2 pIC50 = 9.2 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 493 5 4 4 3.8 C[C@H](NC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O nan
CHEMBL3679659 129497 0 CCR1 CCR1 Human 9.2 pIC50 = 9.2 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 493 5 4 4 3.8 C[C@H](NC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O nan
6918497 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
71570633 86691 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 445 6 3 6 3.2 CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2012.12.095
CHEMBL2332940 86691 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 445 6 3 6 3.2 CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2012.12.095
21070989 86221 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxis
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86221 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxis
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
66686405 174393 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 10.1016/j.bmcl.2018.11.015
CHEMBL4571977 174393 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 10.1016/j.bmcl.2018.11.015
57889003 90483 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398726 90483 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
57888919 90486 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398729 90486 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
72945510 103608 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 487 7 4 6 3.5 O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 10.1016/j.bmcl.2013.11.062
CHEMBL3099945 103608 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 487 7 4 6 3.5 O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 10.1016/j.bmcl.2013.11.062
9980155 71239 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71239 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
6918497 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards C-C chemokine receptor type 1Binding affinity towards C-C chemokine receptor type 1
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(03)00748-0
CHEMBL277930 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards C-C chemokine receptor type 1Binding affinity towards C-C chemokine receptor type 1
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(03)00748-0
CHEMBL331897 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards C-C chemokine receptor type 1Binding affinity towards C-C chemokine receptor type 1
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(03)00748-0
6918497 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL277930 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL331897 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(01)00176-7
10389562 86681 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 460 7 2 6 3.5 COc1ccc(NC(C)=O)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 10.1016/j.bmcl.2012.12.095
CHEMBL2332930 86681 0 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 460 7 2 6 3.5 COc1ccc(NC(C)=O)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 10.1016/j.bmcl.2012.12.095
6918497 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 112691 1 CCR1 CCR1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
10032207 90113 0 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 536 6 3 7 3.1 O=C(c1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 10.1016/j.bmcl.2013.04.047
CHEMBL2391803 90113 0 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 536 6 3 7 3.1 O=C(c1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 10.1016/j.bmcl.2013.04.047
9954423 86683 0 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 430 6 2 5 3.5 CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2012.12.095
CHEMBL2332932 86683 0 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 430 6 2 5 3.5 CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2012.12.095
10409538 86685 0 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 414 6 2 5 3.0 CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2012.12.095
CHEMBL2332934 86685 0 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 414 6 2 5 3.0 CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2012.12.095
57889003 90483 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Antagonist activity at human CCR1 assessed as inhibition of RANTES-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of RANTES-induced chemotaxis
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398726 90483 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Antagonist activity at human CCR1 assessed as inhibition of RANTES-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of RANTES-induced chemotaxis
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
10003548 71394 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71394 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
11743399 71904 7 CCR1 CCR1 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 71904 7 CCR1 CCR1 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405176 134620 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL372807 134620 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
57889327 90474 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 420 6 2 3 3.7 CC(C)[C@@H](NC(=O)CC1CC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398717 90474 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 420 6 2 3 3.7 CC(C)[C@@H](NC(=O)CC1CC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
25175119 129489 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 533 5 3 5 3.0 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(S(N)(=O)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679651 129489 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 533 5 3 5 3.0 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(S(N)(=O)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
44537841 639 1 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
57889181 639 1 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
9497 639 1 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
CHEMBL2398716 639 1 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
CHEMBL3334824 639 1 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
57888993 113737 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 471 6 3 3 4.3 CC(C)[C@@H](NC(=O)NCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1021/jm5003167
CHEMBL3334818 113737 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 471 6 3 3 4.3 CC(C)[C@@H](NC(=O)NCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1021/jm5003167
44309143 197068 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 481 11 4 6 2.9 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN 10.1016/j.bmcl.2004.02.022
CHEMBL66159 197068 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 481 11 4 6 2.9 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN 10.1016/j.bmcl.2004.02.022
59278286 170716 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Inhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysisInhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysis
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464625 170716 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Inhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysisInhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysis
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
25175119 129489 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 533 5 3 5 3.0 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(S(N)(=O)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679651 129489 0 CCR1 CCR1 Human 9.0 pIC50 = 9 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 533 5 3 5 3.0 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(S(N)(=O)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
68963686 90120 0 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 516 6 3 7 2.9 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCC(O)CC1 10.1016/j.bmcl.2013.04.047
CHEMBL2391810 90120 0 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 516 6 3 7 2.9 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCC(O)CC1 10.1016/j.bmcl.2013.04.047
512282 716 46 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
767 716 46 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
CHEMBL232656 716 46 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
57889430 90485 0 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398728 90485 0 CCR1 CCR1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
57888834 90501 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 436 7 2 3 4.4 CC(C)CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C 10.1016/j.bmcl.2013.04.079
CHEMBL2398744 90501 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 436 7 2 3 4.4 CC(C)CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C 10.1016/j.bmcl.2013.04.079
59278147 172150 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 492 5 1 6 3.9 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4518015 172150 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 492 5 1 6 3.9 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2018.12.024
57889764 90523 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 457 6 2 4 3.6 CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398769 90523 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 457 6 2 4 3.6 CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
6918497 112691 1 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 112691 1 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 112691 1 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
71655299 90107 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 529 7 2 7 3.0 CN(C)[C@@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 10.1016/j.bmcl.2013.04.047
CHEMBL2391797 90107 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 529 7 2 7 3.0 CN(C)[C@@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 10.1016/j.bmcl.2013.04.047
512282 716 46 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
767 716 46 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
CHEMBL232656 716 46 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
25175289 129493 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 446 4 2 3 4.3 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)C2CCCC2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679655 129493 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 446 4 2 3 4.3 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)C2CCCC2)CC[C@]1(O)c1ccc(Cl)cc1 nan
72945311 103605 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 461 6 4 6 3.0 CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.11.062
CHEMBL3099942 103605 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 461 6 4 6 3.0 CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.11.062
25175289 129493 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 446 4 2 3 4.3 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)C2CCCC2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679655 129493 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 446 4 2 3 4.3 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)C2CCCC2)CC[C@]1(O)c1ccc(Cl)cc1 nan
10367570 90105 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 472 7 3 6 3.1 O=C(NC1CC1)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
CHEMBL2391795 90105 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 472 7 3 6 3.1 O=C(NC1CC1)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
10412648 90144 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 474 7 2 5 3.6 O=C(NC1CC1)c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
CHEMBL2391939 90144 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 474 7 2 5 3.6 O=C(NC1CC1)c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
59278115 173990 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 7 2.8 CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4562738 173990 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 7 2.8 CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
57889423 90504 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 434 5 2 3 4.1 CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398747 90504 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 434 5 2 3 4.1 CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
68959770 103603 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 485 6 2 5 4.2 O=C(Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCC1 10.1016/j.bmcl.2013.11.062
CHEMBL3099940 103603 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 485 6 2 5 4.2 O=C(Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCC1 10.1016/j.bmcl.2013.11.062
42602331 86692 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 429 6 3 6 2.7 CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2012.12.095
CHEMBL2332941 86692 0 CCR1 CCR1 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
ChEMBL 429 6 3 6 2.7 CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2012.12.095
21070989 86221 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced chemotaxis
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86221 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced chemotaxis
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
44537841 639 1 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
57889181 639 1 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
9497 639 1 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
CHEMBL2398716 639 1 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
CHEMBL3334824 639 1 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
512282 716 46 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
767 716 46 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
CHEMBL232656 716 46 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
10434371 72377 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72377 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
25141158 175393 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 471 5 2 4 4.4 Cc1cc(C)c(C(=O)NC(C)(C)CC(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)cn1 nan
CHEMBL4436541 175393 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 471 5 2 4 4.4 Cc1cc(C)c(C(=O)NC(C)(C)CC(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)cn1 nan
CHEMBL4594791 175393 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 471 5 2 4 4.4 Cc1cc(C)c(C(=O)NC(C)(C)CC(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)cn1 nan
25175123 129491 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@H]2CC[C@@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679653 129491 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@H]2CC[C@@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 nan
25175123 129491 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@H]2CC[C@@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679653 129491 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@H]2CC[C@@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 nan
57889430 90485 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398728 90485 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
25175288 129492 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 498 5 3 4 4.1 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679654 129492 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 498 5 3 4 4.1 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
25175288 129492 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 498 5 3 4 4.1 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679654 129492 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 498 5 3 4 4.1 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
57889230 90496 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 484 8 2 3 5.0 CC(C)[C@@H](NC(=O)CCCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398739 90496 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 484 8 2 3 5.0 CC(C)[C@@H](NC(=O)CCCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
57888834 90501 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 436 7 2 3 4.4 CC(C)CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C 10.1016/j.bmcl.2013.04.079
CHEMBL2398744 90501 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 436 7 2 3 4.4 CC(C)CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C 10.1016/j.bmcl.2013.04.079
25206951 174492 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 434 5 2 3 4.3 CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)C1CCCC1 nan
CHEMBL4574123 174492 0 CCR1 CCR1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 434 5 2 3 4.3 CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)C1CCCC1 nan
42602328 90103 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 446 6 3 6 2.6 CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
CHEMBL2391793 90103 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 446 6 3 6 2.6 CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
10368175 90118 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 486 6 2 6 3.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCC1 10.1016/j.bmcl.2013.04.047
CHEMBL2391808 90118 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 486 6 2 6 3.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCC1 10.1016/j.bmcl.2013.04.047
66686405 174393 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 10.1016/j.bmcl.2018.11.015
CHEMBL4571977 174393 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 10.1016/j.bmcl.2018.11.015
57889897 90494 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 456 6 2 3 4.2 CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398737 90494 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 456 6 2 3 4.2 CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
52916803 170143 8 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4456123 170143 8 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 10.1016/j.bmcl.2018.12.024
57889071 90503 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 420 5 2 3 3.7 CC(C)[C@@H](NC(=O)C1CCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398746 90503 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 420 5 2 3 3.7 CC(C)[C@@H](NC(=O)C1CCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
59444283 171544 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 485 6 3 4 3.5 CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1cccc(C(N)=O)c1 nan
CHEMBL4476397 171544 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 485 6 3 4 3.5 CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1cccc(C(N)=O)c1 nan
59474992 129494 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 497 5 3 4 3.5 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(N)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679656 129494 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 497 5 3 4 3.5 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(N)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
72945313 103606 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 521 7 4 6 4.2 O=C(Nc1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 10.1016/j.bmcl.2013.11.062
CHEMBL3099943 103606 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 521 7 4 6 4.2 O=C(Nc1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 10.1016/j.bmcl.2013.11.062
72945314 103607 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 501 8 3 6 3.8 COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 10.1016/j.bmcl.2013.11.062
CHEMBL3099944 103607 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 501 8 3 6 3.8 COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 10.1016/j.bmcl.2013.11.062
59474992 129494 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 497 5 3 4 3.5 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(N)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679656 129494 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 497 5 3 4 3.5 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(N)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 nan
10436125 90114 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 502 6 3 7 2.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 10.1016/j.bmcl.2013.04.047
CHEMBL2391804 90114 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 502 6 3 7 2.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 10.1016/j.bmcl.2013.04.047
57889334 90500 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 422 6 2 3 4.0 CC(C)CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C 10.1016/j.bmcl.2013.04.079
CHEMBL2398743 90500 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 422 6 2 3 4.0 CC(C)CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C 10.1016/j.bmcl.2013.04.079
59444225 170837 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 467 6 4 4 3.4 C[C@H](NC(=O)NC(C)(C)CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O nan
CHEMBL4466344 170837 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 467 6 4 4 3.4 C[C@H](NC(=O)NC(C)(C)CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O nan
11803142 11728 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 615 5 1 2 7.8 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
CHEMBL1183314 11728 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 615 5 1 2 7.8 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
CHEMBL289902 11728 0 CCR1 CCR1 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 615 5 1 2 7.8 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
57889736 113732 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
ChEMBL 465 5 4 4 3.0 CC(C)[C@@H](NC(=O)N[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1021/jm5003167
CHEMBL3334727 113732 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
ChEMBL 465 5 4 4 3.0 CC(C)[C@@H](NC(=O)N[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1021/jm5003167
57889679 90515 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 442 5 2 3 4.2 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398761 90515 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 442 5 2 3 4.2 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
57888966 90525 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 476 5 2 3 4.9 CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398771 90525 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 476 5 2 3 4.9 CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
155511620 168746 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 3 6.3 CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
CHEMBL4436061 168746 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 3 6.3 CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
11554849 72273 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72273 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
57889613 90516 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 432 5 2 3 4.3 CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2013.04.079
CHEMBL2398762 90516 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 432 5 2 3 4.3 CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2013.04.079
57840192 86130 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 460 5 0 7 2.3 COc1cc(N2CCN(C(=O)Cn3nc(S(C)(=O)=O)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2321887 86130 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 460 5 0 7 2.3 COc1cc(N2CCN(C(=O)Cn3nc(S(C)(=O)=O)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
57840295 86191 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 407 4 0 6 2.7 COc1cc(N2CCN(C(=O)Cn3nc(C#N)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322847 86191 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 407 4 0 6 2.7 COc1cc(N2CCN(C(=O)Cn3nc(C#N)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
57840511 86213 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 466 5 1 6 3.1 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CO)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322867 86213 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 466 5 1 6 3.1 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CO)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
71719855 86226 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 484 4 0 5 4.5 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(Cl)c1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322880 86226 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 484 4 0 5 4.5 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(Cl)c1Cl 10.1016/j.bmcl.2013.01.005
17753030 86343 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232441 86343 0 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
59278314 169077 9 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Inhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysisInhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysis
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4441094 169077 9 CCR1 CCR1 Human 8.0 pIC50 = 8 Binding
Inhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysisInhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysis
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
44453265 94701 0 CCR1 CCR1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL256821 94701 0 CCR1 CCR1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 10.1016/j.bmcl.2007.09.068
44453400 94849 0 CCR1 CCR1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 460 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL257509 94849 0 CCR1 CCR1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 460 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl 10.1016/j.bmcl.2007.09.068
10003548 71394 0 CCR1 CCR1 Human 7.0 pIC50 = 7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71394 0 CCR1 CCR1 Human 7.0 pIC50 = 7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
21070993 86220 0 CCR1 CCR1 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 434 3 0 4 4.2 Cc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322874 86220 0 CCR1 CCR1 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 434 3 0 4 4.2 Cc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
57888715 82197 0 CCR1 CCR1 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 426 5 1 2 5.1 Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)c1C 10.1021/jm300896d
CHEMBL2180511 82197 0 CCR1 CCR1 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 426 5 1 2 5.1 Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)c1C 10.1021/jm300896d
10072252 72039 0 CCR1 CCR1 Mouse 6.0 pIC50 = 6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72039 0 CCR1 CCR1 Mouse 6.0 pIC50 = 6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405203 71907 0 CCR1 CCR1 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 71907 0 CCR1 CCR1 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
44405202 72414 0 CCR1 CCR1 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
CHEMBL200794 72414 0 CCR1 CCR1 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
44430755 152623 0 CCR1 CCR1 Mouse 6.0 pIC50 = 6 Binding
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL397910 152623 0 CCR1 CCR1 Mouse 6.0 pIC50 = 6 Binding
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453527 96850 0 CCR1 CCR1 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 477 4 0 4 4.7 N#CC1(c2ccc(Cl)cc2)CCN(C2CCN(S(=O)(=O)c3ccccc3Cl)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270563 96850 0 CCR1 CCR1 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 477 4 0 4 4.7 N#CC1(c2ccc(Cl)cc2)CCN(C2CCN(S(=O)(=O)c3ccccc3Cl)CC2)CC1 10.1016/j.bmcl.2007.09.068
5481702 199379 1 CCR1 CCR1 Human 5.0 pIC50 = 5 Binding
Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR1 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR1 receptor
ChEMBL 556 8 0 4 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 10.1016/s0960-894x(00)00639-9
CHEMBL83338 199379 1 CCR1 CCR1 Human 5.0 pIC50 = 5 Binding
Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR1 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR1 receptor
ChEMBL 556 8 0 4 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 10.1016/s0960-894x(00)00639-9
11329244 70540 7 CCR1 CCR1 Human 5.0 pIC50 = 5 Binding
Inhibition of C-C chemokine receptor type 1Inhibition of C-C chemokine receptor type 1
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 70540 7 CCR1 CCR1 Human 5.0 pIC50 = 5 Binding
Inhibition of C-C chemokine receptor type 1Inhibition of C-C chemokine receptor type 1
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
11272103 123594 0 CCR1 CCR1 Human 5.0 pIC50 = 5 Binding
Inhibition of C-C chemokine receptor type 1Inhibition of C-C chemokine receptor type 1
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 123594 0 CCR1 CCR1 Human 5.0 pIC50 = 5 Binding
Inhibition of C-C chemokine receptor type 1Inhibition of C-C chemokine receptor type 1
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
76322249 105459 0 CCR1 CCR1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 880 16 6 6 11.0 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3137848 105459 0 CCR1 CCR1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 880 16 6 6 11.0 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138130 204633 0 CCR1 CCR1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138370 204633 0 CCR1 CCR1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
14338 4120 106 CCR1 CCR1 Human 4.0 pIC50 = 4 Binding
Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsDisplacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4120 106 CCR1 CCR1 Human 4.0 pIC50 = 4 Binding
Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsDisplacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
72792 193310 71 CCR1 CCR1 Human 4.0 pIC50 = 4 Binding
Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsDisplacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 193310 71 CCR1 CCR1 Human 4.0 pIC50 = 4 Binding
Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsDisplacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
72945512 103610 0 Q9JLY8 CCR1 Rat 7.0 pIC50 = 7 Binding
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
ChEMBL 471 7 4 6 3.0 O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)NC1CC1 10.1016/j.bmcl.2013.11.062
CHEMBL3099947 103610 0 Q9JLY8 CCR1 Rat 7.0 pIC50 = 7 Binding
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
ChEMBL 471 7 4 6 3.0 O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)NC1CC1 10.1016/j.bmcl.2013.11.062
44453225 95054 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 440 4 1 5 3.5 O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL258368 95054 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 440 4 1 5 3.5 O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44309060 102277 0 CCR1 CCR1 Human 5.0 pIC50 = 5.0 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 446 10 3 3 4.3 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2004.02.021
CHEMBL306683 102277 0 CCR1 CCR1 Human 5.0 pIC50 = 5.0 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 446 10 3 3 4.3 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2004.02.021
57889664 82152 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 440 7 1 2 5.1 Cc1ccc(CCC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1 10.1021/jm300896d
CHEMBL2180194 82152 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 440 7 1 2 5.1 Cc1ccc(CCC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1 10.1021/jm300896d
10003548 71394 0 CCR1 CCR1 Human 5.0 pIC50 = 5.0 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71394 0 CCR1 CCR1 Human 5.0 pIC50 = 5.0 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
25175449 129478 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 526 4 2 5 4.1 CC1(C)CN(C(=O)[C@H]2CC3(CC[C@H]2NC(=O)c2ccccc2)OCCO3)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679640 129478 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 526 4 2 5 4.1 CC1(C)CN(C(=O)[C@H]2CC3(CC[C@H]2NC(=O)c2ccccc2)OCCO3)CC[C@]1(O)c1ccc(Cl)cc1 nan
25175449 129478 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 526 4 2 5 4.1 CC1(C)CN(C(=O)[C@H]2CC3(CC[C@H]2NC(=O)c2ccccc2)OCCO3)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679640 129478 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 526 4 2 5 4.1 CC1(C)CN(C(=O)[C@H]2CC3(CC[C@H]2NC(=O)c2ccccc2)OCCO3)CC[C@]1(O)c1ccc(Cl)cc1 nan
57888707 90522 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 413 6 1 3 3.8 CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2013.04.079
CHEMBL2398768 90522 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 413 6 1 3 3.8 CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2013.04.079
71718646 86224 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 464 4 0 5 4.2 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C)c1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322878 86224 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 464 4 0 5 4.2 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C)c1Cl 10.1016/j.bmcl.2013.01.005
57888718 82204 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 428 6 1 3 5.0 CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180518 82204 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 428 6 1 3 5.0 CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
10789018 34756 0 CCR1 CCR1 Human 5.0 pIC50 = 5.0 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 435 7 1 4 5.1 N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm990316l
CHEMBL143499 34756 0 CCR1 CCR1 Human 5.0 pIC50 = 5.0 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 435 7 1 4 5.1 N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm990316l
71719253 86199 0 CCR1 CCR1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 480 5 1 6 3.2 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@H](CO)C2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322854 86199 0 CCR1 CCR1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 480 5 1 6 3.2 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@H](CO)C2)ccc1Cl 10.1016/j.bmcl.2013.01.005
25233756 180011 0 CCR1 CCR1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
ChEMBL 467 4 1 2 5.6 Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
CHEMBL475748 180011 0 CCR1 CCR1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
ChEMBL 467 4 1 2 5.6 Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
118714034 113739 0 CCR1 CCR1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 424 6 3 4 2.7 CC(C)[C@@H](NC(=O)C[C@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1021/jm5003167
CHEMBL3334820 113739 0 CCR1 CCR1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 424 6 3 4 2.7 CC(C)[C@@H](NC(=O)C[C@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1021/jm5003167
68496383 169220 0 CCR1 CCR1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 503 5 3 5 3.7 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(C#N)cc1 nan
CHEMBL4443024 169220 0 CCR1 CCR1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 503 5 3 5 3.7 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(C#N)cc1 nan
59474993 129495 0 CCR1 CCR1 Human 8.0 pIC50 = 8.0 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 503 5 3 4 4.4 [C-]#[N+]c1ccc([C@@]2(O)CCN(C(=O)[C@H]3CCCC[C@H]3NC(=O)c3cccc(C(=O)O)c3)CC2(C)C)cc1 nan
CHEMBL3679657 129495 0 CCR1 CCR1 Human 8.0 pIC50 = 8.0 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 503 5 3 4 4.4 [C-]#[N+]c1ccc([C@@]2(O)CCN(C(=O)[C@H]3CCCC[C@H]3NC(=O)c3cccc(C(=O)O)c3)CC2(C)C)cc1 nan
25175448 129476 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 469 4 3 3 4.8 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679639 129476 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 469 4 3 3 4.8 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 nan
25175448 129476 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 469 4 3 3 4.8 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679639 129476 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 469 4 3 3 4.8 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 nan
71655559 90115 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 529 7 2 7 3.0 CN(C)[C@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 10.1016/j.bmcl.2013.04.047
CHEMBL2391805 90115 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 529 7 2 7 3.0 CN(C)[C@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 10.1016/j.bmcl.2013.04.047
44453503 94395 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 10.1016/j.bmcl.2007.09.068
CHEMBL255338 94395 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 10.1016/j.bmcl.2007.09.068
44453291 96733 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL269957 96733 0 CCR1 CCR1 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
68956901 90119 0 Q9JLY8 CCR1 Rat 6.0 pIC50 = 6.0 Binding
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
ChEMBL 500 6 2 6 3.9 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCCC1 10.1016/j.bmcl.2013.04.047
CHEMBL2391809 90119 0 Q9JLY8 CCR1 Rat 6.0 pIC50 = 6.0 Binding
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
ChEMBL 500 6 2 6 3.9 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCCC1 10.1016/j.bmcl.2013.04.047
58138765 173570 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4552741 173570 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1 10.1016/j.bmcl.2018.12.024
21071070 86211 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 478 5 0 5 4.7 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C(C)C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322865 86211 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 478 5 0 5 4.7 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C(C)C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
10811980 99246 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 418 6 1 2 5.8 O=C(NC1CCN(CC2CCCCCCC2)CC1)C(c1ccccc1)c1ccccc1 10.1021/jm0004244
CHEMBL286355 99246 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 418 6 1 2 5.8 O=C(NC1CCN(CC2CCCCCCC2)CC1)C(c1ccccc1)c1ccccc1 10.1021/jm0004244
21071081 86219 0 CCR1 CCR1 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 420 3 0 4 3.9 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2013.01.005
CHEMBL2322873 86219 0 CCR1 CCR1 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 420 3 0 4 3.9 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2013.01.005
44453227 94712 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 548 4 1 4 4.5 O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256887 94712 0 CCR1 CCR1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 548 4 1 4 4.5 O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
10367570 90105 0 Q9JLY8 CCR1 Rat 6.9 pIC50 = 6.9 Binding
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
ChEMBL 472 7 3 6 3.1 O=C(NC1CC1)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
CHEMBL2391795 90105 0 Q9JLY8 CCR1 Rat 6.9 pIC50 = 6.9 Binding
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
ChEMBL 472 7 3 6 3.1 O=C(NC1CC1)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
57888832 82146 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 446 6 1 2 5.1 CC(C)[C@@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180188 82146 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 446 6 1 2 5.1 CC(C)[C@@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
44453436 96958 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
CHEMBL271079 96958 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
44453525 96814 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270358 96814 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
24758046 82193 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 416 5 1 2 4.6 CC(C)[C@@H](NC(=O)c1ccc(F)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180507 82193 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 416 5 1 2 4.6 CC(C)[C@@H](NC(=O)c1ccc(F)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
44309194 197116 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 464 11 4 6 2.4 CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL66457 197116 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 464 11 4 6 2.4 CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
12015739 102903 0 CCR1 CCR1 Human 4.9 pIC50 = 4.9 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 413 10 3 4 3.5 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](CC(C)C)NC(=O)c1cnc2ccccc2c1 10.1016/j.bmcl.2004.02.020
CHEMBL308690 102903 0 CCR1 CCR1 Human 4.9 pIC50 = 4.9 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 413 10 3 4 3.5 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](CC(C)C)NC(=O)c1cnc2ccccc2c1 10.1016/j.bmcl.2004.02.020
59444213 170460 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 484 5 2 4 4.2 CC1(C)CN(C(=O)CC2(NC(=O)c3ccccc3)CCOCC2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL4460796 170460 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 484 5 2 4 4.2 CC1(C)CN(C(=O)CC2(NC(=O)c3ccccc3)CCOCC2)CC[C@]1(O)c1ccc(Cl)cc1 nan
59444196 174450 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 442 5 2 3 4.2 CC(NC(=O)c1ccccc1)C(C)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 nan
CHEMBL4573109 174450 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
ChEMBL 442 5 2 3 4.2 CC(NC(=O)c1ccccc1)C(C)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 nan
44430752 87329 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL234295 87329 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
68963562 90112 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 488 6 2 6 2.4 O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)N1CC[C@H](O)C1 10.1016/j.bmcl.2013.04.047
CHEMBL2391802 90112 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 488 6 2 6 2.4 O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)N1CC[C@H](O)C1 10.1016/j.bmcl.2013.04.047
10073725 90122 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 476 8 4 7 2.0 O=C(NCCO)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
CHEMBL2391812 90122 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 476 8 4 7 2.0 O=C(NCCO)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
57889974 90484 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398727 90484 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
44430752 87329 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL234295 87329 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
59278305 169192 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4442765 169192 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
59278307 170712 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 5 1 7 3.0 CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464575 170712 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 5 1 7 3.0 CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
44470374 175029 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 507 6 1 6 3.0 CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1 10.1016/j.bmcl.2018.12.024
CHEMBL4586189 175029 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 507 6 1 6 3.0 CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1 10.1016/j.bmcl.2018.12.024
21070989 86221 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human THP1 cellsDisplacement of [125I]-CCL15/Leukotactin1 from CCR1 in human THP1 cells
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86221 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human THP1 cellsDisplacement of [125I]-CCL15/Leukotactin1 from CCR1 in human THP1 cells
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
21070983 86222 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 464 5 0 5 4.3 CCOc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322876 86222 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 464 5 0 5 4.3 CCOc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
71718022 86232 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 480 5 1 6 3.4 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(CO)c1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322886 86232 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 480 5 1 6 3.4 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(CO)c1Cl 10.1016/j.bmcl.2013.01.005
44430752 87329 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL234295 87329 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
11803142 11728 0 CCR1 CCR1 Mouse 7.9 pIC50 = 7.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 615 5 1 2 7.8 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
CHEMBL1183314 11728 0 CCR1 CCR1 Mouse 7.9 pIC50 = 7.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 615 5 1 2 7.8 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
CHEMBL289902 11728 0 CCR1 CCR1 Mouse 7.9 pIC50 = 7.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 615 5 1 2 7.8 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
6918497 112691 1 CCR1 CCR1 Mouse 7.9 pIC50 = 7.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 112691 1 CCR1 CCR1 Mouse 7.9 pIC50 = 7.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 112691 1 CCR1 CCR1 Mouse 7.9 pIC50 = 7.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
25175446 129475 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 450 3 2 4 4.5 CC(C)(C)OC(=O)N[C@@H]1CCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 nan
CHEMBL3679638 129475 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 450 3 2 4 4.5 CC(C)(C)OC(=O)N[C@@H]1CCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 nan
25175446 129475 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 450 3 2 4 4.5 CC(C)(C)OC(=O)N[C@@H]1CCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 nan
CHEMBL3679638 129475 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 450 3 2 4 4.5 CC(C)(C)OC(=O)N[C@@H]1CCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 nan
44453162 94585 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 526 4 1 4 4.6 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
CHEMBL256272 94585 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 526 4 1 4 4.6 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
44453199 94983 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL258064 94983 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmcl.2007.09.068
44469804 171178 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
CHEMBL4471579 171178 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
44405203 71907 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 71907 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
71560163 86195 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 411 5 1 6 2.3 COc1cc(N2CCN(C(=O)Cn3nc(CN)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322850 86195 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 411 5 1 6 2.3 COc1cc(N2CCN(C(=O)Cn3nc(CN)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
57840312 86217 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 382 4 0 5 2.9 COc1cc(N2CCN(C(=O)Cn3ncc(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322871 86217 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 382 4 0 5 2.9 COc1cc(N2CCN(C(=O)Cn3ncc(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
25233754 178470 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
ChEMBL 473 4 1 2 5.7 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl 10.1021/jm801416q
CHEMBL473531 178470 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
ChEMBL 473 4 1 2 5.7 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl 10.1021/jm801416q
57889591 82224 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 398 6 1 2 4.6 CCCC(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180538 82224 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 398 6 1 2 4.6 CCCC(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
44309407 102252 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 476 9 4 6 2.5 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 10.1016/j.bmcl.2004.02.022
CHEMBL306457 102252 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 476 9 4 6 2.5 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 10.1016/j.bmcl.2004.02.022
155549724 173015 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 427 4 1 3 5.4 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4539264 173015 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
ChEMBL 427 4 1 3 5.4 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.11.015
44468442 169713 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4450029 169713 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
155530458 170700 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 5 2 4 4.0 O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO 10.1016/j.bmcl.2018.11.015
CHEMBL4464403 170700 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 5 2 4 4.0 O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO 10.1016/j.bmcl.2018.11.015
44468440 172513 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 346 4 1 4 3.5 O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4527255 172513 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 346 4 1 4 3.5 O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
24758630 82180 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 438 5 1 2 5.4 O=C(N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C1CCCCC1)c1ccccc1 10.1021/jm300896d
CHEMBL2180494 82180 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 438 5 1 2 5.4 O=C(N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C1CCCCC1)c1ccccc1 10.1021/jm300896d
57889696 82213 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 384 5 1 2 4.3 CC[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180527 82213 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 384 5 1 2 4.3 CC[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
57888938 90520 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 477 6 2 4 3.1 CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2013.04.079
CHEMBL2398766 90520 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 477 6 2 4 3.1 CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2013.04.079
44453357 96834 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270419 96834 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
11124782 117720 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
ChEMBL 587 11 3 3 7.3 O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL341306 117720 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
ChEMBL 587 11 3 3 7.3 O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
44453525 96814 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270358 96814 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44309161 197615 0 CCR1 CCR1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 462 9 3 6 2.3 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 10.1016/j.bmcl.2004.02.022
CHEMBL69876 197615 0 CCR1 CCR1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 462 9 3 6 2.3 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 10.1016/j.bmcl.2004.02.022
69435853 103614 0 Q9JLY8 CCR1 Rat 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
ChEMBL 444 5 2 6 2.9 O=C1COc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2N1 10.1016/j.bmcl.2013.11.062
CHEMBL3099951 103614 0 Q9JLY8 CCR1 Rat 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
ChEMBL 444 5 2 6 2.9 O=C1COc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2N1 10.1016/j.bmcl.2013.11.062
44453357 96834 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270419 96834 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL3138123 204631 0 CCR1 CCR1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CSCC[C@H](NC(=O)c1cc(C(=CCC[C@H]2CC[C@@]3(C)C(CC[C@@H]4[C@@H]3CC[C@@]3(C)[C@H]4CC[C@@H]3C(C)CCCC(C)C)C2)c2cc(Cl)c(O)c(C(=O)N[C@@H](CCSC)C(=O)O)c2)cc(Cl)c1O)C(=O)O 10.1016/s0960-894x(00)00601-6
44453638 165656 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL427834 165656 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
57889164 90517 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 476 5 3 4 4.1 CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398763 90517 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 476 5 3 4 4.1 CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
44430746 86449 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232638 86449 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
155564974 174630 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 3 5.9 CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
CHEMBL4577357 174630 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 3 5.9 CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
10388824 132653 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 132653 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44431529 87320 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Binding Affinity at CCL3Binding Affinity at CCL3
ChEMBL 490 9 1 5 4.0 C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)CCC(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 10.1016/j.bmcl.2007.03.037
CHEMBL234263 87320 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Binding Affinity at CCL3Binding Affinity at CCL3
ChEMBL 490 9 1 5 4.0 C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)CCC(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 10.1016/j.bmcl.2007.03.037
57889660 90497 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 380 4 2 3 2.9 CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C 10.1016/j.bmcl.2013.04.079
CHEMBL2398740 90497 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 380 4 2 3 2.9 CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C 10.1016/j.bmcl.2013.04.079
21070989 86221 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human monocytesDisplacement of [125I]-CCL15/Leukotactin1 from CCR1 in human monocytes
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86221 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human monocytesDisplacement of [125I]-CCL15/Leukotactin1 from CCR1 in human monocytes
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
24758296 82144 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 430 6 1 2 4.6 CC(C)[C@@H](NC(=O)Cc1ccccc1F)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180186 82144 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 430 6 1 2 4.6 CC(C)[C@@H](NC(=O)Cc1ccccc1F)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
72945111 103623 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 459 7 3 6 2.8 CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2013.11.062
CHEMBL3099960 103623 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 459 7 3 6 2.8 CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 10.1016/j.bmcl.2013.11.062
44309397 197383 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 466 11 3 5 3.4 CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL68366 197383 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 466 11 3 5 3.4 CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
68958915 90111 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 470 6 2 6 2.2 O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1ccccc1O2)N1CC[C@H](O)C1 10.1016/j.bmcl.2013.04.047
CHEMBL2391801 90111 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
ChEMBL 470 6 2 6 2.2 O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1ccccc1O2)N1CC[C@H](O)C1 10.1016/j.bmcl.2013.04.047
44453320 96800 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270253 96800 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453579 154780 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL404465 154780 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44430755 152623 0 Q9JLY8 CCR1 Rat 6.9 pIC50 = 6.9 Binding
Binding affinity at rat CCR1Binding affinity at rat CCR1
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL397910 152623 0 Q9JLY8 CCR1 Rat 6.9 pIC50 = 6.9 Binding
Binding affinity at rat CCR1Binding affinity at rat CCR1
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
57888652 82225 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 412 6 1 2 4.9 CC(C)CC(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180539 82225 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 412 6 1 2 4.9 CC(C)CC(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
44309267 197627 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 447 10 3 4 3.7 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2n1 10.1016/j.bmcl.2004.02.021
CHEMBL69978 197627 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 447 10 3 4 3.7 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2n1 10.1016/j.bmcl.2004.02.021
44309364 197493 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 494 12 3 5 4.0 CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 10.1016/j.bmcl.2004.02.022
CHEMBL69123 197493 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 494 12 3 5 4.0 CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 10.1016/j.bmcl.2004.02.022
44453615 94480 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL255797 94480 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
25231480 187061 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
ChEMBL 389 4 1 2 4.1 CN(Cc1ccc(F)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 10.1021/jm801416q
CHEMBL517261 187061 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
ChEMBL 389 4 1 2 4.1 CN(Cc1ccc(F)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 10.1021/jm801416q
72947880 103619 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 445 5 2 7 3.7 Nc1nc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2s1 10.1016/j.bmcl.2013.11.062
CHEMBL3099956 103619 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 445 5 2 7 3.7 Nc1nc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2s1 10.1016/j.bmcl.2013.11.062
69437067 103620 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 444 5 1 6 4.5 Cc1nc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2s1 10.1016/j.bmcl.2013.11.062
CHEMBL3099957 103620 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 444 5 1 6 4.5 Cc1nc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2s1 10.1016/j.bmcl.2013.11.062
10628025 10889 0 CCR1 CCR1 Mouse 5.9 pIC50 = 5.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 523 6 1 2 7.6 O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 10.1021/jm0004244
CHEMBL1178588 10889 0 CCR1 CCR1 Mouse 5.9 pIC50 = 5.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 523 6 1 2 7.6 O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 10.1021/jm0004244
CHEMBL33586 10889 0 CCR1 CCR1 Mouse 5.9 pIC50 = 5.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 523 6 1 2 7.6 O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 10.1021/jm0004244
44453464 94616 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 488 4 1 4 3.9 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256449 94616 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 488 4 1 4 3.9 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453402 94889 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL257698 94889 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 10.1016/j.bmcl.2007.09.068
11082578 117322 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
ChEMBL 603 10 3 3 7.5 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F 10.1021/jm0201767
CHEMBL340491 117322 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
ChEMBL 603 10 3 3 7.5 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F 10.1021/jm0201767
10456104 71404 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197375 71404 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44430723 86173 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232253 86173 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
71719254 86227 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 528 4 0 5 4.6 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(Br)c1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322881 86227 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 528 4 0 5 4.6 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(Br)c1Cl 10.1016/j.bmcl.2013.01.005
25175122 129490 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@@H]2CC[C@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679652 129490 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@@H]2CC[C@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 nan
24758297 82194 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 434 5 1 2 4.8 CC(C)[C@@H](NC(=O)c1ccc(F)c(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180508 82194 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 434 5 1 2 4.8 CC(C)[C@@H](NC(=O)c1ccc(F)c(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
10769447 10895 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 447 4 1 2 6.0 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 10.1021/jm0004244
CHEMBL1178601 10895 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 447 4 1 2 6.0 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 10.1021/jm0004244
CHEMBL34165 10895 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 447 4 1 2 6.0 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 10.1021/jm0004244
25175122 129490 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@@H]2CC[C@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679652 129490 0 CCR1 CCR1 Human 7.9 pIC50 = 7.9 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@@H]2CC[C@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 nan
44537841 639 1 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 mins
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
57889181 639 1 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 mins
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
9497 639 1 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 mins
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
CHEMBL2398716 639 1 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 mins
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
CHEMBL3334824 639 1 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 mins
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
25174956 129488 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 465 5 4 4 3.0 C[C@@H](O)CNC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 nan
CHEMBL3679650 129488 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 465 5 4 4 3.0 C[C@@H](O)CNC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 nan
25174956 129488 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 465 5 4 4 3.0 C[C@@H](O)CNC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 nan
CHEMBL3679650 129488 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 465 5 4 4 3.0 C[C@@H](O)CNC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 nan
24782826 186738 5 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL514611 186738 5 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.07.082
24782826 186738 5 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1021/jm801416q
CHEMBL514611 186738 5 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1021/jm801416q
57889255 82147 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 426 6 1 2 4.7 Cc1ccc(CC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1 10.1021/jm300896d
CHEMBL2180189 82147 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 426 6 1 2 4.7 Cc1ccc(CC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1 10.1021/jm300896d
44430726 86346 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 502 8 2 7 2.6 CNc1c(Nc2cc(F)c(F)cc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232455 86346 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 502 8 2 7 2.6 CNc1c(Nc2cc(F)c(F)cc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453293 166578 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 486 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
CHEMBL429591 166578 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 486 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
10765199 112089 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 432 4 1 3 5.9 O=C(NC1CCN(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 10.1021/jm0004244
CHEMBL33074 112089 0 CCR1 CCR1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 432 4 1 3 5.9 O=C(NC1CCN(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 10.1021/jm0004244
10676520 10888 0 CCR1 CCR1 Mouse 6.9 pIC50 = 6.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 617 5 1 2 7.9 CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
CHEMBL1178581 10888 0 CCR1 CCR1 Mouse 6.9 pIC50 = 6.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 617 5 1 2 7.9 CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
CHEMBL33340 10888 0 CCR1 CCR1 Mouse 6.9 pIC50 = 6.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 617 5 1 2 7.9 CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
10509339 12082 0 CCR1 CCR1 Mouse 6.9 pIC50 = 6.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 631 6 1 2 8.3 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
CHEMBL1185511 12082 0 CCR1 CCR1 Mouse 6.9 pIC50 = 6.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 631 6 1 2 8.3 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
CHEMBL418589 12082 0 CCR1 CCR1 Mouse 6.9 pIC50 = 6.9 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
ChEMBL 631 6 1 2 8.3 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 10.1021/jm0004244
44453614 154458 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL402825 154458 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
44453614 154458 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL402825 154458 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
10368788 90106 0 Q9JLY8 CCR1 Rat 4.9 pIC50 = 4.9 Binding
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
ChEMBL 502 6 3 7 2.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@@H](O)C1 10.1016/j.bmcl.2013.04.047
CHEMBL2391796 90106 0 Q9JLY8 CCR1 Rat 4.9 pIC50 = 4.9 Binding
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
ChEMBL 502 6 3 7 2.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@@H](O)C1 10.1016/j.bmcl.2013.04.047
10436125 90114 0 Q9JLY8 CCR1 Rat 4.9 pIC50 = 4.9 Binding
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
ChEMBL 502 6 3 7 2.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 10.1016/j.bmcl.2013.04.047
CHEMBL2391804 90114 0 Q9JLY8 CCR1 Rat 4.9 pIC50 = 4.9 Binding
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
ChEMBL 502 6 3 7 2.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 10.1016/j.bmcl.2013.04.047
11814253 116210 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
ChEMBL 635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1 10.1021/jm0201767
CHEMBL338624 116210 0 CCR1 CCR1 Human 5.9 pIC50 = 5.9 Binding
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
ChEMBL 635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1 10.1021/jm0201767
71455572 82209 0 CCR1 CCR1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 398 5 1 2 4.5 CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180523 82209 0 CCR1 CCR1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 398 5 1 2 4.5 CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
24758044 82214 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPRAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPR
ChEMBL 398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180528 82214 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPRAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPR
ChEMBL 398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
21070989 86221 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 in human monocytes assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisAntagonist activity at CCR1 in human monocytes assessed as inhibition of CCL15/Leukotactin1-induced chemotaxis
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86221 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 in human monocytes assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisAntagonist activity at CCR1 in human monocytes assessed as inhibition of CCL15/Leukotactin1-induced chemotaxis
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
57889660 90497 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 380 4 2 3 2.9 CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C 10.1016/j.bmcl.2013.04.079
CHEMBL2398740 90497 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 380 4 2 3 2.9 CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C 10.1016/j.bmcl.2013.04.079
44480600 174216 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4568048 174216 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.11.015
57889158 90491 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 443 5 2 4 3.6 CC(C)[C@@H](NC(=O)c1ccccn1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398734 90491 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 443 5 2 4 3.6 CC(C)[C@@H](NC(=O)c1ccccn1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
44430754 165850 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2ccccn2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL428193 165850 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2ccccn2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44309165 197580 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 490 9 3 6 3.0 CC1CC([C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)C(N)=O)CC(C)O1 10.1016/j.bmcl.2004.02.021
CHEMBL69659 197580 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 490 9 3 6 3.0 CC1CC([C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)C(N)=O)CC(C)O1 10.1016/j.bmcl.2004.02.021
25174462 129484 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 496 6 2 3 5.1 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CCc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679646 129484 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
ChEMBL 496 6 2 3 5.1 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CCc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 nan
25174462 129484 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 496 6 2 3 5.1 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CCc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 nan
CHEMBL3679646 129484 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
ChEMBL 496 6 2 3 5.1 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CCc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 nan
44405212 72388 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200680 72388 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
10001921 71874 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 71874 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
44453202 94608 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 422 7 2 4 3.3 Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256404 94608 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 422 7 2 4 3.3 Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
10555351 115415 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 586 4 1 3 7.3 O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Br)ccc2Oc2ccc(Br)cc21 10.1021/jm0004244
CHEMBL33580 115415 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 586 4 1 3 7.3 O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Br)ccc2Oc2ccc(Br)cc21 10.1021/jm0004244
512282 716 46 CCR1 CCR1 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 716 46 CCR1 CCR1 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 716 46 CCR1 CCR1 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
10388824 132653 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 132653 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44309155 197608 0 CCR1 CCR1 Human 4.8 pIC50 = 4.8 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 453 10 3 4 4.5 CNC(=O)[C@@H](CC(C)C)C[C@@H](O)[C@@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 10.1016/j.bmcl.2004.02.020
CHEMBL69822 197608 0 CCR1 CCR1 Human 4.8 pIC50 = 4.8 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 453 10 3 4 4.5 CNC(=O)[C@@H](CC(C)C)C[C@@H](O)[C@@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 10.1016/j.bmcl.2004.02.020
24758743 82210 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 364 6 1 2 4.0 CC[C@@H](NC(=O)CC(C)C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180524 82210 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 364 6 1 2 4.0 CC[C@@H](NC(=O)CC(C)C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
57888775 82227 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 412 6 1 2 5.0 CCCC(NC(=O)c1ccccc1C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180541 82227 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 412 6 1 2 5.0 CCCC(NC(=O)c1ccccc1C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
57889484 90518 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 532 7 3 3 5.7 CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2013.04.079
CHEMBL2398764 90518 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
ChEMBL 532 7 3 3 5.7 CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2013.04.079
10393066 103611 0 Q9JLY8 CCR1 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
ChEMBL 447 6 4 6 2.7 NC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.11.062
CHEMBL3099948 103611 0 Q9JLY8 CCR1 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
ChEMBL 447 6 4 6 2.7 NC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.11.062
49865900 15824 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 448 4 1 3 6.0 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224118 15824 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 448 4 1 3 6.0 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
24782574 178496 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 453 4 1 2 5.3 Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
CHEMBL473734 178496 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 453 4 1 2 5.3 Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
9980155 71239 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71239 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
11351191 86189 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 440 5 1 6 3.1 COc1cc(N2CCN(C(=O)Cn3nc(C(C)(C)O)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322845 86189 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 440 5 1 6 3.1 COc1cc(N2CCN(C(=O)Cn3nc(C(C)(C)O)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
71718023 86233 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 479 5 1 6 3.3 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(CN)c1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322887 86233 0 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
ChEMBL 479 5 1 6 3.3 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(CN)c1Cl 10.1016/j.bmcl.2013.01.005
72945313 103606 0 Q9JLY8 CCR1 Rat 7.8 pIC50 = 7.8 Binding
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
ChEMBL 521 7 4 6 4.2 O=C(Nc1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 10.1016/j.bmcl.2013.11.062
CHEMBL3099943 103606 0 Q9JLY8 CCR1 Rat 7.8 pIC50 = 7.8 Binding
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
ChEMBL 521 7 4 6 4.2 O=C(Nc1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 10.1016/j.bmcl.2013.11.062
44537841 639 1 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 mins
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
57889181 639 1 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 mins
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
9497 639 1 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 mins
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
CHEMBL2398716 639 1 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 mins
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
CHEMBL3334824 639 1 CCR1 CCR1 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 mins
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1021/jm5003167
42602328 90103 0 Q9JLY8 CCR1 Rat 6.8 pIC50 = 6.8 Binding
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
ChEMBL 446 6 3 6 2.6 CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
CHEMBL2391793 90103 0 Q9JLY8 CCR1 Rat 6.8 pIC50 = 6.8 Binding
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
ChEMBL 446 6 3 6 2.6 CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.04.047
69437029 103618 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 427 5 1 5 4.6 Cc1cc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2o1 10.1016/j.bmcl.2013.11.062
CHEMBL3099955 103618 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
ChEMBL 427 5 1 5 4.6 Cc1cc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2o1 10.1016/j.bmcl.2013.11.062
44430742 141250 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 557 11 2 8 2.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN(C)C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387821 141250 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 557 11 2 8 2.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN(C)C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44430724 151218 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 484 8 2 7 2.5 CNc1c(Nc2cc(F)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL396700 151218 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
ChEMBL 484 8 2 7 2.5 CNc1c(Nc2cc(F)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453529 97151 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 414 7 2 5 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1 10.1016/j.bmcl.2007.09.068
CHEMBL272097 97151 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
ChEMBL 414 7 2 5 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1 10.1016/j.bmcl.2007.09.068
44309347 197842 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 516 10 3 5 4.4 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)c1cnc2ccccc2n1 10.1016/j.bmcl.2004.02.021
CHEMBL71242 197842 0 CCR1 CCR1 Human 6.8 pIC50 = 6.8 Binding
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
ChEMBL 516 10 3 5 4.4 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)c1cnc2ccccc2n1 10.1016/j.bmcl.2004.02.021
44405234 132506 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370447 132506 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10575889 33275 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 458 8 1 3 6.3 N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL142199 33275 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 458 8 1 3 6.3 N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
10502989 112584 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 434 6 2 3 4.9 O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)c1ccccc1 10.1021/jm0004244
CHEMBL33159 112584 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
ChEMBL 434 6 2 3 4.9 O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)c1ccccc1 10.1021/jm0004244
57991685 90477 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 449 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
CHEMBL2398720 90477 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Binding
Binding affinity to human CCR1Binding affinity to human CCR1
ChEMBL 449 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 10.1016/j.bmcl.2013.04.079
10482996 103613 0 Q9JLY8 CCR1 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
ChEMBL 449 6 3 5 3.2 NC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.11.062
CHEMBL3099950 103613 0 Q9JLY8 CCR1 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
ChEMBL 449 6 3 5 3.2 NC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 10.1016/j.bmcl.2013.11.062
44453084 94583 0 CCR1 CCR1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 6 2 3 4.6 O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068