Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
10210629 | 8766 | None | 0 | Human | Functional | pIC50 | = | 9.9 | 9.9 | 2 | 4 | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL109644 | 8766 | None | 0 | Human | Functional | pIC50 | = | 9.9 | 9.9 | 2 | 4 | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
9870830 | 209172 | None | 29 | Human | Functional | pIC50 | = | 9.5 | 9.5 | -1 | 4 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL8981 | 209172 | None | 29 | Human | Functional | pIC50 | = | 9.5 | 9.5 | -1 | 4 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00008a002 | |||
23670447 | 3029 | None | 2 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm00008a002 | |||
999 | 3029 | None | 2 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm00008a002 | |||
CHEMBL1204799 | 3029 | None | 2 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm00008a002 | |||
CHEMBL25438 | 3029 | None | 2 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm00008a002 | |||
10187997 | 110028 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | 1 | 4 | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL323464 | 110028 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | 1 | 4 | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
9916235 | 9355 | None | 1 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 1 | 4 | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL111277 | 9355 | None | 1 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 1 | 4 | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
10603409 | 110667 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 1 | 4 | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | |||
CHEMBL325581 | 110667 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 1 | 4 | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | |||
9915028 | 9413 | None | 19 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -34 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL4507258 | |||
CHEMBL111612 | 9413 | None | 19 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -34 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL4507258 | |||
CHEMBL4761843 | 9413 | None | 19 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -34 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL4507258 | |||
443289 | 711 | None | 39 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2016.06.006 | |||||
997 | 711 | None | 39 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2016.06.006 | |||||
CHEMBL314691 | 711 | None | 39 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2016.06.006 | |||||
DB12054 | 711 | None | 39 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2016.06.006 | |||||
CHEMBL3980643 | 214974 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -6 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC | 10.1016/j.ejmech.2016.06.006 | |||||
10230737 | 112383 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 16 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL329251 | 112383 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 16 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
11318978 | 168006 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 7 | 2 | ChEMBL | 560 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL431286 | 168006 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 7 | 2 | ChEMBL | 560 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | |||
10651488 | 163474 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 1 | 4 | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | |||
CHEMBL419367 | 163474 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 1 | 4 | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | |||
CHEMBL412706 | 215479 | None | 0 | Pig | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00349-X | |||||
9894443 | 112636 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 3 | 2 | ChEMBL | 576 | 7 | 2 | 6 | 5.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL330104 | 112636 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 3 | 2 | ChEMBL | 576 | 7 | 2 | 6 | 5.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | |||
9955200 | 9334 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 53 | 3 | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL11115 | 9334 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 53 | 3 | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
70690542 | 76248 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 532 | 9 | 1 | 6 | 6.6 | CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058375 | 76248 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 532 | 9 | 1 | 6 | 6.6 | CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
70696781 | 76249 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 582 | 9 | 1 | 6 | 7.5 | CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058376 | 76249 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 582 | 9 | 1 | 6 | 7.5 | CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
11342089 | 107264 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 9 | 2 | ChEMBL | 568 | 9 | 2 | 8 | 4.0 | COc1ccc(CN2C(=O)CN[C@](c3cccc(OC)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL316629 | 107264 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 9 | 2 | ChEMBL | 568 | 9 | 2 | 8 | 4.0 | COc1ccc(CN2C(=O)CN[C@](c3cccc(OC)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
10230703 | 210318 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 4 | 2 | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96472 | 210318 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 4 | 2 | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | |||
9957883 | 98710 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | 25 | 2 | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL27732 | 98710 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | 25 | 2 | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | |||
44213651 | 4299 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 343 | 3 | 1 | 4 | 4.2 | OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL100795 | 4299 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 343 | 3 | 1 | 4 | 4.2 | OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
11455999 | 210288 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | 31 | 2 | ChEMBL | 580 | 7 | 2 | 4 | 6.6 | O=C(O)[C@@H](Oc1cccc(Cl)c1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 | 10.1021/jm031115r | |||
CHEMBL96325 | 210288 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | 31 | 2 | ChEMBL | 580 | 7 | 2 | 4 | 6.6 | O=C(O)[C@@H](Oc1cccc(Cl)c1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 | 10.1021/jm031115r | |||
11490160 | 209960 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | 5 | 2 | ChEMBL | 584 | 8 | 2 | 6 | 5.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(-c4ccccc4)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL94446 | 209960 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | 5 | 2 | ChEMBL | 584 | 8 | 2 | 6 | 5.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(-c4ccccc4)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11273181 | 210325 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -4 | 2 | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C(F)(F)F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96506 | 210325 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -4 | 2 | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C(F)(F)F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL386778 | 214850 | None | 0 | Pig | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
CHEMBL405337 | 215017 | None | 0 | Pig | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
CHEMBL405916 | 215045 | None | 0 | Pig | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
CHEMBL409180 | 215210 | None | 0 | Pig | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
6450144 | 122627 | None | 6 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 632 | 5 | 3 | 6 | 8.1 | CC1(C)CC[C@]2(C(=O)O)CC[C@]3(COC(=O)/C=C/c4ccc(O)c(O)c4)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 | 10.1016/j.bmc.2015.06.055 | |||
CHEMBL3601500 | 122627 | None | 6 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 632 | 5 | 3 | 6 | 8.1 | CC1(C)CC[C@]2(C(=O)O)CC[C@]3(COC(=O)/C=C/c4ccc(O)c(O)c4)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 | 10.1016/j.bmc.2015.06.055 | |||
70684240 | 76250 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 559 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058377 | 76250 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 559 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
11421972 | 210304 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 2 | 2 | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(OC(F)(F)F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96422 | 210304 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 2 | 2 | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(OC(F)(F)F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11342005 | 210008 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 2 | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)c(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL94766 | 210008 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 2 | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)c(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11744509 | 5432 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | 5 | 2 | ChEMBL | 450 | 5 | 1 | 6 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10733 | 5432 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | 5 | 2 | ChEMBL | 450 | 5 | 1 | 6 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 | 10.1021/jm00008a002 | |||
122194935 | 124161 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 619 | 11 | 2 | 8 | 6.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(S(F)(F)(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO | 10.1021/acs.jmedchem.5b00258 | |||
CHEMBL3633040 | 124161 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 619 | 11 | 2 | 8 | 6.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(S(F)(F)(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO | 10.1021/acs.jmedchem.5b00258 | |||
11387205 | 111624 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 544 | 8 | 2 | 7 | 4.5 | COc1ccc(CN2C(=O)CN[C@](C3CCCCC3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL328073 | 111624 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 544 | 8 | 2 | 7 | 4.5 | COc1ccc(CN2C(=O)CN[C@](C3CCCCC3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL62302 | 218333 | None | 0 | Pig | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
10342643 | 5159 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 144 | 2 | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm00008a002 | |||
CHEMBL10588 | 5159 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 144 | 2 | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm00008a002 | |||
10342643 | 5159 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 144 | 2 | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm00008a002 | |||
CHEMBL10588 | 5159 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 144 | 2 | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm00008a002 | |||
10224745 | 112753 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 15 | 2 | ChEMBL | 432 | 5 | 2 | 6 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL330425 | 112753 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 15 | 2 | ChEMBL | 432 | 5 | 2 | 6 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | |||
9865706 | 98187 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 1 | 2 | ChEMBL | 400 | 4 | 1 | 5 | 4.1 | Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL273613 | 98187 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 1 | 2 | ChEMBL | 400 | 4 | 1 | 5 | 4.1 | Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | |||
10452089 | 4567 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 375 | 3 | 0 | 5 | 4.1 | COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL102494 | 4567 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 375 | 3 | 0 | 5 | 4.1 | COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 | 10.1016/S0960-894X(96)00551-3 | |||
11432855 | 210313 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 28 | 2 | ChEMBL | 552 | 8 | 3 | 7 | 3.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(=O)O)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96463 | 210313 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 28 | 2 | ChEMBL | 552 | 8 | 3 | 7 | 3.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(=O)O)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11318559 | 210261 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 5 | 2 | ChEMBL | 531 | 8 | 2 | 8 | 2.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN3CCOCC3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96193 | 210261 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 5 | 2 | ChEMBL | 531 | 8 | 2 | 8 | 2.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN3CCOCC3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11238540 | 209984 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 11 | 2 | ChEMBL | 576 | 8 | 2 | 5 | 5.9 | COc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL94602 | 209984 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 11 | 2 | ChEMBL | 576 | 8 | 2 | 5 | 5.9 | COc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
10140418 | 106257 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 43 | 2 | ChEMBL | 476 | 7 | 3 | 7 | 1.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC(=O)O)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL313867 | 106257 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 43 | 2 | ChEMBL | 476 | 7 | 3 | 7 | 1.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC(=O)O)c3ccccc32)n1 | 10.1021/jm031115r | |||
11308052 | 112728 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 2 | ChEMBL | 618 | 10 | 2 | 6 | 5.8 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL330354 | 112728 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 2 | ChEMBL | 618 | 10 | 2 | 6 | 5.8 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 | 10.1021/jm031115r | |||
122194934 | 124160 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 561 | 10 | 2 | 8 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO | 10.1021/acs.jmedchem.5b00258 | |||
CHEMBL3633039 | 124160 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 561 | 10 | 2 | 8 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO | 10.1021/acs.jmedchem.5b00258 | |||
CHEMBL97470 | 218415 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
CHEMBL3143473 | 213793 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -1071 | 2 | ChEMBL | None | None | None | CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00084-7 | |||||
CHEMBL3305972 | 213793 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -1071 | 2 | ChEMBL | None | None | None | CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00084-7 | |||||
345351 | 9361 | None | 3 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 24 | 3 | ChEMBL | 386 | 4 | 1 | 5 | 3.8 | O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
CHEMBL11131 | 9361 | None | 3 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 24 | 3 | ChEMBL | 386 | 4 | 1 | 5 | 3.8 | O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
44332623 | 4768 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 320 | 3 | 1 | 4 | 2.9 | Cc1cc(C(C(N)=O)c2ccc3c(c2)OCO3)c2ccccc2n1 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL103886 | 4768 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 320 | 3 | 1 | 4 | 2.9 | Cc1cc(C(C(N)=O)c2ccc3c(c2)OCO3)c2ccccc2n1 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL405599 | 215028 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 3 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
11744509 | 5432 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 5 | 2 | ChEMBL | 450 | 5 | 1 | 6 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10733 | 5432 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 5 | 2 | ChEMBL | 450 | 5 | 1 | 6 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 | 10.1021/jm00008a002 | |||
11386977 | 210006 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 1 | 2 | ChEMBL | 528 | 8 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCC3CCCCC3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL94752 | 210006 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 1 | 2 | ChEMBL | 528 | 8 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCC3CCCCC3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11226767 | 209985 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 6 | 2 | ChEMBL | 560 | 7 | 2 | 4 | 6.2 | Cc1ccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL94606 | 209985 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 6 | 2 | ChEMBL | 560 | 7 | 2 | 4 | 6.2 | Cc1ccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)cc1 | 10.1021/jm031115r | |||
11452452 | 209660 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 404 | 5 | 2 | 6 | 1.8 | CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncccn2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | |||
CHEMBL92612 | 209660 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 404 | 5 | 2 | 6 | 1.8 | CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncccn2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | |||
CHEMBL284250 | 213319 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -19 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1016/0960-894X(95)00237-N | |||||
11331242 | 107476 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 652 | 8 | 2 | 6 | 7.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL318086 | 107476 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 652 | 8 | 2 | 6 | 7.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL265116 | 213094 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -3 | 3 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | |||||
CHEMBL4533479 | 216452 | None | 1 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -1 | 2 | ChEMBL | None | None | None | CCCOc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 | 10.6019/CHEMBL4507261 | |||||
10166981 | 209546 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 2 | 2 | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(F)(F)F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL91926 | 209546 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 2 | 2 | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(F)(F)F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11410074 | 210249 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 536 | 9 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96114 | 210249 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 536 | 9 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11365059 | 210254 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 564 | 7 | 2 | 6 | 5.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(C)(C)C)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96154 | 210254 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 564 | 7 | 2 | 6 | 5.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(C)(C)C)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
10347783 | 210293 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 32 | 2 | ChEMBL | 560 | 7 | 2 | 4 | 5.6 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL96347 | 210293 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 32 | 2 | ChEMBL | 560 | 7 | 2 | 4 | 5.6 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 | 10.1021/jm031115r | |||
11753090 | 106259 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 7 | 2 | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Cl)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL313870 | 106259 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 7 | 2 | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Cl)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
10412464 | 9139 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 11 | 2 | ChEMBL | 470 | 6 | 1 | 5 | 5.4 | COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10996 | 9139 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 11 | 2 | ChEMBL | 470 | 6 | 1 | 5 | 5.4 | COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
44327656 | 141876 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -1 | 2 | ChEMBL | 977 | 25 | 9 | 8 | 4.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||
CHEMBL386181 | 141876 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -1 | 2 | ChEMBL | 977 | 25 | 9 | 8 | 4.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||
11330923 | 210281 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 606 | 10 | 2 | 6 | 6.3 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(C)cc(C)cc3C)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL96303 | 210281 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 606 | 10 | 2 | 6 | 6.3 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(C)cc(C)cc3C)c3ccccc32)c1 | 10.1021/jm031115r | |||
11226740 | 210361 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 9 | 2 | ChEMBL | 558 | 7 | 2 | 4 | 6.0 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL96704 | 210361 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 9 | 2 | ChEMBL | 558 | 7 | 2 | 4 | 6.0 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL408574 | 215182 | None | 0 | Pig | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
10410546 | 9414 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 37 | 2 | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL11162 | 9414 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 37 | 2 | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL319537 | 213678 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 2 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
CHEMBL409808 | 215246 | None | 0 | Pig | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
10120430 | 209979 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 5 | 2 | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)ccc(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL94580 | 209979 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 5 | 2 | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)ccc(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
9890440 | 8256 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 301 | 2 | ChEMBL | 460 | 6 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10924 | 8256 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 301 | 2 | ChEMBL | 460 | 6 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 | 10.1021/jm00008a002 | |||
10166543 | 112425 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 33 | 2 | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL329477 | 112425 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 33 | 2 | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
10282008 | 209539 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 12 | 2 | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(OC(F)(F)F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL91873 | 209539 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 12 | 2 | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(OC(F)(F)F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11224973 | 107506 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 32 | 2 | ChEMBL | 460 | 7 | 2 | 6 | 2.9 | CCc1cc(CC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL318270 | 107506 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 32 | 2 | ChEMBL | 460 | 7 | 2 | 6 | 2.9 | CCc1cc(CC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | |||
11169125 | 210018 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 5 | 2 | ChEMBL | 574 | 7 | 2 | 4 | 6.5 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL94802 | 210018 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 5 | 2 | ChEMBL | 574 | 7 | 2 | 4 | 6.5 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL263295 | 213024 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | |||||
10024044 | 7841 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 402 | 6 | 1 | 5 | 4.1 | COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10897 | 7841 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 402 | 6 | 1 | 5 | 4.1 | COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
44332577 | 4708 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 341 | 3 | 0 | 4 | 4.4 | O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL103484 | 4708 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 341 | 3 | 0 | 4 | 4.4 | O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL2373086 | 212831 | None | 0 | Pig | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
3951 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | |||
4337 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | |||
6918493 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | |||
6918493.0 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | |||
CHEMBL1111 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | |||
DB06403 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | |||
CHEMBL317099 | 213657 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -69 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
CHEMBL96822 | 218410 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NS(C)(=O)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
11786120 | 169271 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 17 | 2 | ChEMBL | 546 | 7 | 2 | 4 | 5.9 | O=C(O)[C@@H](Oc1ccccc1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 | 10.1021/jm031115r | |||
CHEMBL440507 | 169271 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 17 | 2 | ChEMBL | 546 | 7 | 2 | 4 | 5.9 | O=C(O)[C@@H](Oc1ccccc1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 | 10.1021/jm031115r | |||
70692693 | 76242 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 500 | 8 | 1 | 6 | 6.1 | CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058369 | 76242 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 500 | 8 | 1 | 6 | 6.1 | CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
10385531 | 112745 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 387 | 4 | 0 | 6 | 4.4 | COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL330414 | 112745 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 387 | 4 | 0 | 6 | 4.4 | COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 | 10.1016/S0960-894X(96)00551-3 | |||
10024044 | 7841 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 402 | 6 | 1 | 5 | 4.1 | COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10897 | 7841 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 402 | 6 | 1 | 5 | 4.1 | COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
10070783 | 97109 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 3 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 4.5 | O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
CHEMBL267094 | 97109 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 3 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 4.5 | O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
11387315 | 209893 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -1 | 2 | ChEMBL | 552 | 8 | 2 | 7 | 4.3 | COc1ccc(CN2C(=O)CN[C@](c3ccc(C)cc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL94091 | 209893 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -1 | 2 | ChEMBL | 552 | 8 | 2 | 7 | 4.3 | COc1ccc(CN2C(=O)CN[C@](c3ccc(C)cc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
11408654 | 210395 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 19 | 2 | ChEMBL | 464 | 7 | 2 | 8 | 1.8 | COc1cc(OC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96906 | 210395 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 19 | 2 | ChEMBL | 464 | 7 | 2 | 8 | 1.8 | COc1cc(OC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | |||
11409474 | 210019 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 502 | 10 | 2 | 6 | 4.4 | CCCCCCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | |||
CHEMBL94810 | 210019 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 502 | 10 | 2 | 6 | 4.4 | CCCCCCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | |||
44327659 | 109878 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | -1 | 2 | ChEMBL | 937 | 26 | 9 | 8 | 4.6 | CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 | 10.1021/jm00015a003 | |||
CHEMBL323331 | 109878 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | -1 | 2 | ChEMBL | 937 | 26 | 9 | 8 | 4.6 | CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 | 10.1021/jm00015a003 | |||
CHEMBL263186 | 213021 | None | 0 | Pig | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
9896251 | 98827 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 3 | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL278176 | 98827 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 3 | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/j.bmc.2012.06.011 | |||
11467573 | 107296 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 9 | 2 | ChEMBL | 606 | 8 | 2 | 7 | 5.0 | COc1ccc(CN2C(=O)CN[C@](c3cccc(C(F)(F)F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL316851 | 107296 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 9 | 2 | ChEMBL | 606 | 8 | 2 | 7 | 5.0 | COc1ccc(CN2C(=O)CN[C@](c3cccc(C(F)(F)F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
11238500 | 210283 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 3 | 2 | ChEMBL | 572 | 8 | 2 | 7 | 4.7 | COc1ccc(CN2C(=O)CN[C@](c3cccc(Cl)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL96313 | 210283 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 3 | 2 | ChEMBL | 572 | 8 | 2 | 7 | 4.7 | COc1ccc(CN2C(=O)CN[C@](c3cccc(Cl)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
11753582 | 210047 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 4 | 2 | ChEMBL | 586 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Br)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL94962 | 210047 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 4 | 2 | ChEMBL | 586 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Br)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11397857 | 210250 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 6 | 2 | ChEMBL | 496 | 7 | 2 | 6 | 3.7 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccc(Cl)cc32)c1 | 10.1021/jm031115r | |||
CHEMBL96125 | 210250 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 6 | 2 | ChEMBL | 496 | 7 | 2 | 6 | 3.7 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccc(Cl)cc32)c1 | 10.1021/jm031115r | |||
11489946 | 209806 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 2 | 2 | ChEMBL | 566 | 8 | 2 | 7 | 4.6 | COc1ccc(CN2C(=O)CN[C@](c3cc(C)cc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL93612 | 209806 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 2 | 2 | ChEMBL | 566 | 8 | 2 | 7 | 4.6 | COc1ccc(CN2C(=O)CN[C@](c3cc(C)cc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL433406 | 216101 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | -9 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
44332803 | 4709 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 335 | 3 | 0 | 5 | 3.6 | COC(=O)C(c1ccc2c(c1)OCO2)c1cc(C)nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL103497 | 4709 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 335 | 3 | 0 | 5 | 3.6 | COC(=O)C(c1ccc2c(c1)OCO2)c1cc(C)nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
9820754 | 108618 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 371 | 3 | 0 | 5 | 4.4 | COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL320236 | 108618 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 371 | 3 | 0 | 5 | 4.4 | COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
11410410 | 210009 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 25 | 2 | ChEMBL | 560 | 7 | 2 | 4 | 6.2 | Cc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL94769 | 210009 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 25 | 2 | ChEMBL | 560 | 7 | 2 | 4 | 6.2 | Cc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL319660 | 213679 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 2 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | |||||
CHEMBL410694 | 215294 | None | 0 | Pig | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
CHEMBL411965 | 215426 | None | 0 | Pig | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
11387934 | 107233 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 28 | 2 | ChEMBL | 614 | 9 | 2 | 7 | 5.7 | COc1ccc(CN2C(=O)CN[C@](c3cccc(-c4ccccc4)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL316453 | 107233 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 28 | 2 | ChEMBL | 614 | 9 | 2 | 7 | 5.7 | COc1ccc(CN2C(=O)CN[C@](c3cccc(-c4ccccc4)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
11353580 | 210397 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 21 | 2 | ChEMBL | 566 | 9 | 2 | 7 | 4.6 | CCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL96932 | 210397 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 21 | 2 | ChEMBL | 566 | 9 | 2 | 7 | 4.6 | CCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 | 10.1021/jm031115r | |||
10303258 | 161969 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 3 | 2 | ChEMBL | 564 | 10 | 2 | 6 | 5.3 | CCCCc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL415010 | 161969 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 3 | 2 | ChEMBL | 564 | 10 | 2 | 6 | 5.3 | CCCCc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
11168474 | 210364 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 9 | 2 | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96723 | 210364 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 9 | 2 | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
11421392 | 209844 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 5 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL93820 | 209844 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 5 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
11489318 | 210258 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 5 | 2 | ChEMBL | 522 | 8 | 2 | 6 | 4.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96171 | 210258 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 5 | 2 | ChEMBL | 522 | 8 | 2 | 6 | 4.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL94983 | 218406 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 7 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
11398818 | 168034 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 2 | 2 | ChEMBL | 556 | 8 | 2 | 7 | 4.2 | COc1ccc(CN2C(=O)CN[C@](c3ccccc3F)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL431460 | 168034 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 2 | 2 | ChEMBL | 556 | 8 | 2 | 7 | 4.2 | COc1ccc(CN2C(=O)CN[C@](c3ccccc3F)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
11156692 | 167979 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 2 | 2 | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL431087 | 167979 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 2 | 2 | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
10412464 | 9139 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 11 | 2 | ChEMBL | 470 | 6 | 1 | 5 | 5.4 | COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10996 | 9139 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 11 | 2 | ChEMBL | 470 | 6 | 1 | 5 | 5.4 | COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
10410546 | 9414 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 37 | 2 | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL11162 | 9414 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 37 | 2 | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
15289330 | 99856 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 18 | 2 | ChEMBL | 493 | 8 | 1 | 8 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL285368 | 99856 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 18 | 2 | ChEMBL | 493 | 8 | 1 | 8 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL97431 | 218414 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 2 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | |||||
18995989 | 100609 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -2 | 2 | ChEMBL | 583 | 9 | 1 | 9 | 6.6 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL29147 | 100609 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -2 | 2 | ChEMBL | 583 | 9 | 1 | 9 | 6.6 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 | 10.1016/0960-894X(96)00232-6 | |||
11307120 | 112467 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -4 | 2 | ChEMBL | 532 | 11 | 2 | 7 | 4.5 | CCCCC[C@]1([C@H](Oc2nc(C)cc(C)n2)C(=O)O)NCC(=O)N(Cc2ccc(OC)cc2)c2ccccc21 | 10.1021/jm031115r | |||
CHEMBL329744 | 112467 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -4 | 2 | ChEMBL | 532 | 11 | 2 | 7 | 4.5 | CCCCC[C@]1([C@H](Oc2nc(C)cc(C)n2)C(=O)O)NCC(=O)N(Cc2ccc(OC)cc2)c2ccccc21 | 10.1021/jm031115r | |||
1009 | 194 | None | 25 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -1479 | 2 | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL4507261 | |||
5310991 | 194 | None | 25 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -1479 | 2 | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL4507261 | |||
CHEMBL332794 | 194 | None | 25 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -1479 | 2 | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL4507261 | |||
11362537 | 107577 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 24 | 2 | ChEMBL | 434 | 6 | 2 | 7 | 1.8 | COc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 | 10.1021/jm031115r | |||
CHEMBL318683 | 107577 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 24 | 2 | ChEMBL | 434 | 6 | 2 | 7 | 1.8 | COc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 | 10.1021/jm031115r | |||
11167889 | 210294 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 496 | 7 | 2 | 6 | 3.7 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(Cl)ccc32)c1 | 10.1021/jm031115r | |||
CHEMBL96351 | 210294 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 496 | 7 | 2 | 6 | 3.7 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(Cl)ccc32)c1 | 10.1021/jm031115r | |||
11752174 | 172828 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 4 | 2 | ChEMBL | 489 | 8 | 2 | 7 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN(C)C)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL450628 | 172828 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 4 | 2 | ChEMBL | 489 | 8 | 2 | 7 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN(C)C)c3ccccc32)n1 | 10.1021/jm031115r | |||
70686381 | 76241 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | -1 | 2 | ChEMBL | 486 | 7 | 1 | 6 | 5.7 | CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058368 | 76241 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | -1 | 2 | ChEMBL | 486 | 7 | 1 | 6 | 5.7 | CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
11785180 | 111571 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 492 | 8 | 2 | 7 | 3.1 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)ccc32)c1 | 10.1021/jm031115r | |||
CHEMBL327823 | 111571 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 492 | 8 | 2 | 7 | 3.1 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)ccc32)c1 | 10.1021/jm031115r | |||
CHEMBL1790448 | 211347 | None | 0 | Pig | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)[C@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
CHEMBL293029 | 213347 | None | 0 | Pig | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00349-X | |||||
CHEMBL410869 | 215307 | None | 0 | Pig | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
10230546 | 107303 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 4 | 2 | ChEMBL | 538 | 8 | 2 | 7 | 4.0 | COc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL316878 | 107303 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 4 | 2 | ChEMBL | 538 | 8 | 2 | 7 | 4.0 | COc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
9807691 | 100118 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 134 | 2 | ChEMBL | 553 | 10 | 1 | 10 | 5.3 | COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL287169 | 100118 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 134 | 2 | ChEMBL | 553 | 10 | 1 | 10 | 5.3 | COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | |||
44304492 | 96613 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 1 | 4 | ChEMBL | 949 | 23 | 9 | 8 | 4.3 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||
CHEMBL262993 | 96613 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 1 | 4 | ChEMBL | 949 | 23 | 9 | 8 | 4.3 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||
10027018 | 98542 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 454 | 4 | 1 | 5 | 5.1 | O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
CHEMBL275991 | 98542 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 454 | 4 | 1 | 5 | 5.1 | O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
CHEMBL94907 | 218404 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | |||||
10070783 | 97109 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 3 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 4.5 | O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
CHEMBL267094 | 97109 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 3 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 4.5 | O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
CHEMBL2370255 | 212278 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -13 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
CHEMBL433349 | 216098 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -1 | 3 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
CHEMBL2370254 | 212277 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 2 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
11168401 | 112367 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 18 | 2 | ChEMBL | 522 | 9 | 2 | 8 | 3.1 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)c(OC)cc32)c1 | 10.1021/jm031115r | |||
CHEMBL329132 | 112367 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 18 | 2 | ChEMBL | 522 | 9 | 2 | 8 | 3.1 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)c(OC)cc32)c1 | 10.1021/jm031115r | |||
11156376 | 112729 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 5 | 2 | ChEMBL | 504 | 9 | 3 | 7 | 2.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCC(=O)O)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL330359 | 112729 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 5 | 2 | ChEMBL | 504 | 9 | 3 | 7 | 2.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCC(=O)O)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL318020 | 213668 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 8 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | |||||
11330927 | 209966 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 8 | 2 | ChEMBL | 606 | 9 | 2 | 6 | 5.9 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL94488 | 209966 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 8 | 2 | ChEMBL | 606 | 9 | 2 | 6 | 5.9 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
10385531 | 112745 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 387 | 4 | 0 | 6 | 4.4 | COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL330414 | 112745 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 387 | 4 | 0 | 6 | 4.4 | COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 | 10.1016/S0960-894X(96)00551-3 | |||
9865706 | 98187 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 1 | 2 | ChEMBL | 400 | 4 | 1 | 5 | 4.1 | Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL273613 | 98187 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 1 | 2 | ChEMBL | 400 | 4 | 1 | 5 | 4.1 | Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL264330 | 213071 | None | 0 | Pig | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00349-X | |||||
CHEMBL386850 | 214857 | None | 0 | Pig | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00349-X | |||||
11318409 | 209914 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 3 | 2 | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1cccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL94212 | 209914 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 3 | 2 | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1cccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c1 | 10.1021/jm031115r | |||
10187261 | 111603 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 3 | 2 | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Cl)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL327976 | 111603 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 3 | 2 | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Cl)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11785813 | 106978 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 8 | 2 | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL314755 | 106978 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 8 | 2 | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL408616 | 215184 | None | 0 | Pig | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
9845562 | 4743 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 7 | 3 | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10374 | 4743 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 7 | 3 | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 | 10.1021/jm00008a002 | |||
11742628 | 98288 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 25 | 3 | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL274383 | 98288 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 25 | 3 | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | |||
9845562 | 4743 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 7 | 3 | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10374 | 4743 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 7 | 3 | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL411797 | 215417 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
10226239 | 210347 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 4 | 2 | ChEMBL | 456 | 5 | 2 | 8 | 2.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(C)n3-c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96614 | 210347 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 4 | 2 | ChEMBL | 456 | 5 | 2 | 8 | 2.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(C)n3-c3ccccc32)n1 | 10.1021/jm031115r | |||
10027018 | 98542 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 454 | 4 | 1 | 5 | 5.1 | O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
CHEMBL275991 | 98542 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 454 | 4 | 1 | 5 | 5.1 | O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
44332578 | 4316 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 413 | 3 | 0 | 5 | 5.6 | CC(C)(C)OC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL100874 | 4316 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 413 | 3 | 0 | 5 | 5.6 | CC(C)(C)OC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
122272 | 97150 | None | 32 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -4 | 4 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00029a001 | |||
CHEMBL267458 | 97150 | None | 32 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -4 | 4 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00029a001 | |||
10047521 | 8632 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 416 | 6 | 1 | 5 | 4.4 | COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10951 | 8632 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 416 | 6 | 1 | 5 | 4.4 | COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
11156301 | 78695 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 4 | 2 | ChEMBL | 500 | 7 | 3 | 9 | 2.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(CC(=O)O)n3-c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL2112377 | 78695 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 4 | 2 | ChEMBL | 500 | 7 | 3 | 9 | 2.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(CC(=O)O)n3-c3ccccc32)n1 | 10.1021/jm031115r | |||
9820754 | 108618 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 371 | 3 | 0 | 5 | 4.4 | COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL320236 | 108618 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 371 | 3 | 0 | 5 | 4.4 | COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
11203972 | 106933 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 576 | 8 | 2 | 5 | 5.9 | COc1ccccc1O[C@H](C(=O)O)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 | 10.1021/jm031115r | |||
CHEMBL314511 | 106933 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 576 | 8 | 2 | 5 | 5.9 | COc1ccccc1O[C@H](C(=O)O)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 | 10.1021/jm031115r | |||
CHEMBL2373085 | 212830 | None | 0 | Pig | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
CHEMBL433837 | 216106 | None | 0 | Pig | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
CHEMBL62641 | 218336 | None | 0 | Pig | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
10187313 | 107500 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 18 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL318247 | 107500 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 18 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
9890440 | 8256 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 301 | 2 | ChEMBL | 460 | 6 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10924 | 8256 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 301 | 2 | ChEMBL | 460 | 6 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 | 10.1021/jm00008a002 | |||
11284285 | 107385 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 8 | 2 | ChEMBL | 552 | 8 | 2 | 7 | 4.3 | COc1ccc(CN2C(=O)CN[C@](c3cccc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL317510 | 107385 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 8 | 2 | ChEMBL | 552 | 8 | 2 | 7 | 4.3 | COc1ccc(CN2C(=O)CN[C@](c3cccc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
11307805 | 107397 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 3 | 2 | ChEMBL | 586 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Br)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL317589 | 107397 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 3 | 2 | ChEMBL | 586 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Br)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11283571 | 210057 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 7 | 2 | ChEMBL | 508 | 7 | 2 | 6 | 4.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL95013 | 210057 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 7 | 2 | ChEMBL | 508 | 7 | 2 | 6 | 4.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11364770 | 163751 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 5 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL420435 | 163751 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 5 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
10209814 | 209729 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 7 | 2 | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL93084 | 209729 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 7 | 2 | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
10163956 | 210048 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 10 | 2 | ChEMBL | 500 | 7 | 3 | 9 | 1.5 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3nn[nH]n3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL94964 | 210048 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 10 | 2 | ChEMBL | 500 | 7 | 3 | 9 | 1.5 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3nn[nH]n3)c3ccccc32)n1 | 10.1021/jm031115r | |||
10166139 | 163439 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 550 | 7 | 2 | 6 | 4.9 | Cc1cc(C)c(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c(C)c1 | 10.1021/jm031115r | |||
CHEMBL419136 | 163439 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 550 | 7 | 2 | 6 | 4.9 | Cc1cc(C)c(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c(C)c1 | 10.1021/jm031115r | |||
11191999 | 209958 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 4 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)ccc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL94438 | 209958 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 4 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)ccc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
11375934 | 210372 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 3 | 2 | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96746 | 210372 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 3 | 2 | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11478911 | 156401 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 4 | 2 | ChEMBL | 598 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)c(F)c(F)c(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL406551 | 156401 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 4 | 2 | ChEMBL | 598 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)c(F)c(F)c(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
10298354 | 112069 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 15 | 2 | ChEMBL | 462 | 7 | 3 | 7 | 1.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCO)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL328878 | 112069 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 15 | 2 | ChEMBL | 462 | 7 | 3 | 7 | 1.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCO)c3ccccc32)n1 | 10.1021/jm031115r | |||
345351 | 9361 | None | 3 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 24 | 3 | ChEMBL | 386 | 4 | 1 | 5 | 3.8 | O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
CHEMBL11131 | 9361 | None | 3 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 24 | 3 | ChEMBL | 386 | 4 | 1 | 5 | 3.8 | O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | |||
CHEMBL329609 | 213777 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | 3 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
11202819 | 112627 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 1 | 2 | ChEMBL | 499 | 6 | 3 | 8 | 3.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3c(C(=O)O)nc(C)n3-c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL330045 | 112627 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 1 | 2 | ChEMBL | 499 | 6 | 3 | 8 | 3.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3c(C(=O)O)nc(C)n3-c3ccccc32)n1 | 10.1021/jm031115r | |||
11385689 | 112859 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 10 | 2 | ChEMBL | 462 | 7 | 2 | 6 | 3.0 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL330629 | 112859 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 10 | 2 | ChEMBL | 462 | 7 | 2 | 6 | 3.0 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)c1 | 10.1021/jm031115r | |||
44283270 | 167984 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2691 | 4 | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1016/0960-894X(95)00237-N | |||
CHEMBL431124 | 167984 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2691 | 4 | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1016/0960-894X(95)00237-N | |||
18995991 | 100354 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 9 | 2 | ChEMBL | 537 | 8 | 1 | 10 | 5.0 | COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL28920 | 100354 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 9 | 2 | ChEMBL | 537 | 8 | 1 | 10 | 5.0 | COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC | 10.1016/0960-894X(96)00232-6 | |||
18995992 | 99892 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 3 | 2 | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL28563 | 99892 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 3 | 2 | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | |||
11465096 | 96818 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 450 | 6 | 2 | 7 | 2.5 | CSc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 | 10.1021/jm031115r | |||
CHEMBL264625 | 96818 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 450 | 6 | 2 | 7 | 2.5 | CSc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 | 10.1021/jm031115r | |||
11235126 | 210386 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 52 | 2 | ChEMBL | 405 | 5 | 2 | 6 | 2.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCOc3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96831 | 210386 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 52 | 2 | ChEMBL | 405 | 5 | 2 | 6 | 2.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCOc3ccccc32)n1 | 10.1021/jm031115r | |||
11478553 | 163545 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 10 | 2 | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL419879 | 163545 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 10 | 2 | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
11330570 | 210043 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 4 | 2 | ChEMBL | 570 | 8 | 2 | 7 | 4.5 | COc1ccc(CN2C(=O)CN[C@](c3ccc(F)c(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL94934 | 210043 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 4 | 2 | ChEMBL | 570 | 8 | 2 | 7 | 4.5 | COc1ccc(CN2C(=O)CN[C@](c3ccc(F)c(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
11155687 | 210286 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 12 | 2 | ChEMBL | 472 | 7 | 2 | 6 | 3.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CC3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96318 | 210286 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 12 | 2 | ChEMBL | 472 | 7 | 2 | 6 | 3.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CC3)c3ccccc32)n1 | 10.1021/jm031115r | |||
10303311 | 107218 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 9 | 2 | ChEMBL | 566 | 8 | 2 | 8 | 3.8 | COC(=O)c1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL316301 | 107218 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 9 | 2 | ChEMBL | 566 | 8 | 2 | 8 | 3.8 | COC(=O)c1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
11742628 | 98288 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 25 | 3 | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL274383 | 98288 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 25 | 3 | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | |||
11477664 | 168270 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 6 | 2 | ChEMBL | 506 | 10 | 2 | 8 | 2.4 | COCCOCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | |||
CHEMBL433173 | 168270 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 6 | 2 | ChEMBL | 506 | 10 | 2 | 8 | 2.4 | COCCOCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | |||
11204331 | 112642 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 616 | 10 | 2 | 6 | 6.1 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL330135 | 112642 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 616 | 10 | 2 | 6 | 6.1 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | |||
11377200 | 108354 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 11 | 2 | ChEMBL | 638 | 8 | 2 | 6 | 6.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL319754 | 108354 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 11 | 2 | ChEMBL | 638 | 8 | 2 | 6 | 6.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | |||
11444738 | 164974 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 4 | 2 | ChEMBL | 594 | 11 | 2 | 7 | 5.4 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 | 10.1021/jm031115r | |||
CHEMBL422068 | 164974 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 4 | 2 | ChEMBL | 594 | 11 | 2 | 7 | 5.4 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 | 10.1021/jm031115r | |||
11398658 | 210058 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)cc(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL95017 | 210058 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)cc(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL319719 | 213680 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -3 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
CHEMBL328942 | 213775 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 1 | 3 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
9980487 | 5272 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 436 | 6 | 1 | 5 | 4.8 | COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10648 | 5272 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 436 | 6 | 1 | 5 | 4.8 | COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
10452089 | 4567 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 375 | 3 | 0 | 5 | 4.1 | COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL102494 | 4567 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 375 | 3 | 0 | 5 | 4.1 | COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 | 10.1016/S0960-894X(96)00551-3 | |||
70694736 | 76240 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 2 | ChEMBL | 472 | 6 | 1 | 6 | 5.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058367 | 76240 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 2 | ChEMBL | 472 | 6 | 1 | 6 | 5.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
134136255 | 142681 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 663 | 11 | 2 | 10 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)nc(-c2ncccn2)nc1OCCO | 10.1016/j.ejmech.2016.06.006 | |||
CHEMBL3891334 | 142681 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 663 | 11 | 2 | 10 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)nc(-c2ncccn2)nc1OCCO | 10.1016/j.ejmech.2016.06.006 | |||
10047521 | 8632 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 416 | 6 | 1 | 5 | 4.4 | COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10951 | 8632 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 416 | 6 | 1 | 5 | 4.4 | COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
44332807 | 107291 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 447 | 5 | 0 | 5 | 6.0 | O=C(OCc1ccccc1)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL316792 | 107291 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 447 | 5 | 0 | 5 | 6.0 | O=C(OCc1ccccc1)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
44332624 | 4182 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 356 | 3 | 1 | 4 | 3.7 | NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL100120 | 4182 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 356 | 3 | 1 | 4 | 3.7 | NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
10336018 | 102163 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -10 | 2 | ChEMBL | 318 | 3 | 2 | 5 | 3.0 | Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C | 10.1021/jm00029a001 | |||
CHEMBL30228 | 102163 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -10 | 2 | ChEMBL | 318 | 3 | 2 | 5 | 3.0 | Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C | 10.1021/jm00029a001 | |||
CHEMBL265614 | 213115 | None | 17 | Pig | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
CHEMBL269189 | 213241 | None | 0 | Pig | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00349-X | |||||
104865 | 706 | None | 60 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -3 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2012.06.011 | |||
104865.0 | 706 | None | 60 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -3 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2012.06.011 | |||
3494 | 706 | None | 60 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -3 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2012.06.011 | |||
392 | 706 | None | 60 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -3 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL957 | 706 | None | 60 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -3 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2012.06.011 | |||
DB00559 | 706 | None | 60 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -3 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2012.06.011 | |||
70694737 | 76245 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 544 | 10 | 1 | 7 | 6.5 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058372 | 76245 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 544 | 10 | 1 | 7 | 6.5 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
11432418 | 107004 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 6 | 2 | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL314946 | 107004 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 6 | 2 | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C)c3ccccc32)n1 | 10.1021/jm031115r | |||
44332638 | 4377 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 477 | 6 | 0 | 6 | 6.0 | COc1ccc(COC(=O)C(c2ccc3c(c2)OCO3)c2c3ccccc3nc3ccccc23)cc1 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL101239 | 4377 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 477 | 6 | 0 | 6 | 6.0 | COc1ccc(COC(=O)C(c2ccc3c(c2)OCO3)c2c3ccccc3nc3ccccc23)cc1 | 10.1016/S0960-894X(96)00551-3 | |||
11489174 | 112611 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 2 | ChEMBL | 514 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CCCCC3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL329943 | 112611 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 2 | ChEMBL | 514 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CCCCC3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL216082 | 211776 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -20 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
44332624 | 4182 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 356 | 3 | 1 | 4 | 3.7 | NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL100120 | 4182 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 356 | 3 | 1 | 4 | 3.7 | NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
44332546 | 107269 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 491 | 5 | 0 | 7 | 5.7 | O=C(OCc1ccc2c(c1)OCO2)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL316648 | 107269 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 491 | 5 | 0 | 7 | 5.7 | O=C(OCc1ccc2c(c1)OCO2)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
9955200 | 9334 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 53 | 3 | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL11115 | 9334 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 53 | 3 | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
11376627 | 107688 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(C(F)(F)F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL319007 | 107688 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(C(F)(F)F)c3)c3ccccc32)n1 | 10.1021/jm031115r | |||
11307457 | 210070 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 5 | 2 | ChEMBL | 556 | 8 | 2 | 7 | 4.2 | COc1ccc(CN2C(=O)CN[C@](c3cccc(F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
CHEMBL95095 | 210070 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 5 | 2 | ChEMBL | 556 | 8 | 2 | 7 | 4.2 | COc1ccc(CN2C(=O)CN[C@](c3cccc(F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | |||
70684239 | 76244 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 528 | 9 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058371 | 76244 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 528 | 9 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
70694738 | 76246 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 548 | 9 | 1 | 6 | 7.2 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058373 | 76246 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 548 | 9 | 1 | 6 | 7.2 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
70686382 | 76243 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 514 | 9 | 1 | 6 | 6.5 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058370 | 76243 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 514 | 9 | 1 | 6 | 6.5 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
70696780 | 76247 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 592 | 9 | 1 | 6 | 7.3 | CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058374 | 76247 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 592 | 9 | 1 | 6 | 7.3 | CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
44213651 | 4299 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 343 | 3 | 1 | 4 | 4.2 | OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL100795 | 4299 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 343 | 3 | 1 | 4 | 4.2 | OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
11441050 | 210290 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | 85 | 2 | ChEMBL | 403 | 5 | 2 | 5 | 3.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCCc3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96331 | 210290 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | 85 | 2 | ChEMBL | 403 | 5 | 2 | 5 | 3.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCCc3ccccc32)n1 | 10.1021/jm031115r | |||
11488556 | 210328 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | 10 | 2 | ChEMBL | 482 | 5 | 2 | 6 | 2.6 | CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncc(Br)cn2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | |||
CHEMBL96520 | 210328 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | 10 | 2 | ChEMBL | 482 | 5 | 2 | 6 | 2.6 | CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncc(Br)cn2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | |||
9980487 | 5272 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 436 | 6 | 1 | 5 | 4.8 | COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
CHEMBL10648 | 5272 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 436 | 6 | 1 | 5 | 4.8 | COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | |||
11456110 | 210298 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3OC(F)(F)F)c3ccccc32)n1 | 10.1021/jm031115r | |||
CHEMBL96387 | 210298 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3OC(F)(F)F)c3ccccc32)n1 | 10.1021/jm031115r | |||
70686380 | 76239 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | -1 | 2 | ChEMBL | 458 | 6 | 1 | 6 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
CHEMBL2058366 | 76239 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | -1 | 2 | ChEMBL | 458 | 6 | 1 | 6 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
44311232 | 206565 | None | 0 | Rat | Functional | pKd | = | 10 | 10.0 | - | 2 | ChEMBL | 658 | 13 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL70293 | 206565 | None | 0 | Rat | Functional | pKd | = | 10 | 10.0 | - | 2 | ChEMBL | 658 | 13 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
9939238 | 206586 | None | 0 | Rat | Functional | pKd | = | 9.7 | 9.7 | - | 2 | ChEMBL | 637 | 12 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL70385 | 206586 | None | 0 | Rat | Functional | pKd | = | 9.7 | 9.7 | - | 2 | ChEMBL | 637 | 12 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
9809919 | 206867 | None | 0 | Rat | Functional | pKd | = | 9.3 | 9.3 | - | 2 | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL72037 | 206867 | None | 0 | Rat | Functional | pKd | = | 9.3 | 9.3 | - | 2 | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
44212539 | 206551 | None | 0 | Rat | Functional | pKd | = | 9 | 9.0 | - | 2 | ChEMBL | 671 | 12 | 2 | 12 | 5.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL70203 | 206551 | None | 0 | Rat | Functional | pKd | = | 9 | 9.0 | - | 2 | ChEMBL | 671 | 12 | 2 | 12 | 5.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
44311233 | 206567 | None | 0 | Rat | Functional | pKd | = | 9 | 9.0 | - | 2 | ChEMBL | 630 | 12 | 2 | 13 | 4.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL70303 | 206567 | None | 0 | Rat | Functional | pKd | = | 9 | 9.0 | - | 2 | ChEMBL | 630 | 12 | 2 | 13 | 4.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
44311516 | 206576 | None | 0 | Rat | Functional | pKd | = | 8 | 8.0 | - | 2 | ChEMBL | 678 | 12 | 2 | 12 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL70339 | 206576 | None | 0 | Rat | Functional | pKd | = | 8 | 8.0 | - | 2 | ChEMBL | 678 | 12 | 2 | 12 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
44311527 | 206581 | None | 0 | Rat | Functional | pKd | = | 8 | 8.0 | - | 2 | ChEMBL | 675 | 12 | 2 | 11 | 7.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL70365 | 206581 | None | 0 | Rat | Functional | pKd | = | 8 | 8.0 | - | 2 | ChEMBL | 675 | 12 | 2 | 11 | 7.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
18184234 | 62229 | None | 0 | Rat | Functional | pKd | = | 7.0 | 7.0 | - | 2 | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL177802 | 62229 | None | 0 | Rat | Functional | pKd | = | 7.0 | 7.0 | - | 2 | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
9807456 | 60493 | None | 0 | Rat | Functional | pKd | = | 7.0 | 7.0 | - | 2 | ChEMBL | 545 | 9 | 1 | 9 | 4.8 | C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL175435 | 60493 | None | 0 | Rat | Functional | pKd | = | 7.0 | 7.0 | - | 2 | ChEMBL | 545 | 9 | 1 | 9 | 4.8 | C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
44311285 | 102354 | None | 0 | Rat | Functional | pKd | = | 7.9 | 7.9 | - | 2 | ChEMBL | 635 | 13 | 2 | 10 | 6.4 | CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL303428 | 102354 | None | 0 | Rat | Functional | pKd | = | 7.9 | 7.9 | - | 2 | ChEMBL | 635 | 13 | 2 | 10 | 6.4 | CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 | 10.1016/S0960-894X(97)00400-9 | |||
9917706 | 129807 | None | 0 | Rat | Functional | pKd | = | 6.9 | 6.9 | - | 2 | ChEMBL | 659 | 15 | 2 | 11 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL367444 | 129807 | None | 0 | Rat | Functional | pKd | = | 6.9 | 6.9 | - | 2 | ChEMBL | 659 | 15 | 2 | 11 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
9869444 | 97299 | None | 0 | Human | Functional | pKd | = | 6.9 | 6.9 | 120 | 2 | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 | 10.1016/0960-894X(96)00170-9 | |||
CHEMBL268751 | 97299 | None | 0 | Human | Functional | pKd | = | 6.9 | 6.9 | 120 | 2 | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 | 10.1016/0960-894X(96)00170-9 | |||
9848132 | 210036 | None | 0 | Rat | Functional | pKd | = | 5.9 | 5.9 | 120 | 2 | ChEMBL | 483 | 6 | 1 | 8 | 2.8 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | |||
CHEMBL94918 | 210036 | None | 0 | Rat | Functional | pKd | = | 5.9 | 5.9 | 120 | 2 | ChEMBL | 483 | 6 | 1 | 8 | 2.8 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | |||
10281606 | 129740 | None | 0 | Rat | Functional | pKd | = | 6.8 | 6.8 | - | 2 | ChEMBL | 575 | 9 | 2 | 10 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL367382 | 129740 | None | 0 | Rat | Functional | pKd | = | 6.8 | 6.8 | - | 2 | ChEMBL | 575 | 9 | 2 | 10 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
44311284 | 206703 | None | 0 | Rat | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 635 | 12 | 2 | 10 | 6.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL71070 | 206703 | None | 0 | Rat | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 635 | 12 | 2 | 10 | 6.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
44311346 | 103218 | None | 0 | Rat | Functional | pKd | = | 6.8 | 6.8 | - | 2 | ChEMBL | 681 | 13 | 2 | 13 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL308088 | 103218 | None | 0 | Rat | Functional | pKd | = | 6.8 | 6.8 | - | 2 | ChEMBL | 681 | 13 | 2 | 13 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL1790962 | 211369 | None | 0 | Pig | Functional | pKd | = | 7.7 | 7.7 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | |||||
CHEMBL2373291 | 212833 | None | 0 | Pig | Functional | pKd | = | 7.7 | 7.7 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | |||||
44311528 | 206600 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 633 | 12 | 2 | 10 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL70487 | 206600 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 633 | 12 | 2 | 10 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
10122675 | 98525 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 682 | 12 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL275897 | 98525 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 682 | 12 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
10146640 | 210013 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 689 | 12 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL94786 | 210013 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 689 | 12 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | |||
10212088 | 96749 | None | 0 | Rat | Functional | pKd | = | 6.7 | 6.7 | - | 2 | ChEMBL | 688 | 12 | 2 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL264035 | 96749 | None | 0 | Rat | Functional | pKd | = | 6.7 | 6.7 | - | 2 | ChEMBL | 688 | 12 | 2 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
10211772 | 56539 | None | 0 | Rat | Functional | pKd | = | 6.6 | 6.6 | - | 2 | ChEMBL | 660 | 11 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL163638 | 56539 | None | 0 | Rat | Functional | pKd | = | 6.6 | 6.6 | - | 2 | ChEMBL | 660 | 11 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
9917072 | 62123 | None | 0 | Rat | Functional | pKd | = | 6.6 | 6.6 | - | 2 | ChEMBL | 619 | 16 | 2 | 10 | 4.6 | CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL177538 | 62123 | None | 0 | Rat | Functional | pKd | = | 6.6 | 6.6 | - | 2 | ChEMBL | 619 | 16 | 2 | 10 | 4.6 | CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
9809270 | 131408 | None | 0 | Rat | Functional | pKd | = | 6.6 | 6.6 | - | 2 | ChEMBL | 622 | 14 | 2 | 12 | 2.3 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL368738 | 131408 | None | 0 | Rat | Functional | pKd | = | 6.6 | 6.6 | - | 2 | ChEMBL | 622 | 14 | 2 | 12 | 2.3 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
9870830 | 209172 | None | 29 | Human | Functional | pKd | = | 7.6 | 7.6 | -1 | 4 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | |||
CHEMBL8981 | 209172 | None | 29 | Human | Functional | pKd | = | 7.6 | 7.6 | -1 | 4 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | |||
44311283 | 102388 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 2 | ChEMBL | 649 | 11 | 2 | 10 | 6.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL303649 | 102388 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 2 | ChEMBL | 649 | 11 | 2 | 10 | 6.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
23670447 | 3029 | None | 2 | Human | Functional | pKd | = | 7.6 | 7.6 | 1 | 4 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(97)10151-2 | |||
999 | 3029 | None | 2 | Human | Functional | pKd | = | 7.6 | 7.6 | 1 | 4 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL1204799 | 3029 | None | 2 | Human | Functional | pKd | = | 7.6 | 7.6 | 1 | 4 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL25438 | 3029 | None | 2 | Human | Functional | pKd | = | 7.6 | 7.6 | 1 | 4 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(97)10151-2 | |||
44386169 | 131457 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 2 | ChEMBL | 690 | 12 | 2 | 14 | 3.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL368996 | 131457 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 2 | ChEMBL | 690 | 12 | 2 | 14 | 3.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
10190108 | 130766 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 2 | ChEMBL | 681 | 12 | 2 | 12 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL368386 | 130766 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 2 | ChEMBL | 681 | 12 | 2 | 12 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | |||
10211781 | 129809 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 2 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL367453 | 129809 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 2 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | |||
18184229 | 59627 | None | 0 | Rat | Functional | pKd | = | 6.5 | 6.5 | - | 2 | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL171950 | 59627 | None | 0 | Rat | Functional | pKd | = | 6.5 | 6.5 | - | 2 | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
9894460 | 209167 | None | 11 | Rat | Functional | pKd | = | 8.5 | 8.5 | -158 | 4 | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/S0960-894X(96)00617-8 | |||
CHEMBL313871 | 209167 | None | 11 | Rat | Functional | pKd | = | 8.5 | 8.5 | -158 | 4 | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/S0960-894X(96)00617-8 | |||
CHEMBL8978 | 209167 | None | 11 | Rat | Functional | pKd | = | 8.5 | 8.5 | -158 | 4 | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/S0960-894X(96)00617-8 | |||
10311570 | 14636 | None | 0 | Human | Functional | pKd | = | 8.5 | 8.5 | - | 2 | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL1205068 | 14636 | None | 0 | Human | Functional | pKd | = | 8.5 | 8.5 | - | 2 | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL48907 | 14636 | None | 0 | Human | Functional | pKd | = | 8.5 | 8.5 | - | 2 | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(97)10151-2 | |||
9830495 | 131217 | None | 0 | Rat | Functional | pKd | = | 6.5 | 6.5 | - | 2 | ChEMBL | 618 | 14 | 2 | 9 | 5.0 | CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL368617 | 131217 | None | 0 | Rat | Functional | pKd | = | 6.5 | 6.5 | - | 2 | ChEMBL | 618 | 14 | 2 | 9 | 5.0 | CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
9874557 | 129806 | None | 0 | Rat | Functional | pKd | = | 6.5 | 6.5 | - | 2 | ChEMBL | 667 | 15 | 2 | 10 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL367443 | 129806 | None | 0 | Rat | Functional | pKd | = | 6.5 | 6.5 | - | 2 | ChEMBL | 667 | 15 | 2 | 10 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | |||
9864880 | 102443 | None | 0 | Human | Functional | pKd | = | 7.5 | 7.5 | - | 1 | ChEMBL | 384 | 4 | 1 | 6 | 3.7 | CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4nsnc4c3)cccc12 | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL303902 | 102443 | None | 0 | Human | Functional | pKd | = | 7.5 | 7.5 | - | 1 | ChEMBL | 384 | 4 | 1 | 6 | 3.7 | CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4nsnc4c3)cccc12 | 10.1016/s0960-894x(97)10151-2 | |||
9810571 | 61406 | None | 0 | Rat | Functional | pKd | = | 5.5 | 5.5 | - | 2 | ChEMBL | 731 | 18 | 2 | 13 | 5.0 | CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL176997 | 61406 | None | 0 | Rat | Functional | pKd | = | 5.5 | 5.5 | - | 2 | ChEMBL | 731 | 18 | 2 | 13 | 5.0 | CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
9873255 | 59653 | None | 0 | Rat | Functional | pKd | = | 6.5 | 6.5 | - | 2 | ChEMBL | 591 | 14 | 2 | 10 | 3.8 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL172071 | 59653 | None | 0 | Rat | Functional | pKd | = | 6.5 | 6.5 | - | 2 | ChEMBL | 591 | 14 | 2 | 10 | 3.8 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL2373292 | 212834 | None | 0 | Pig | Functional | pKd | = | 7.4 | 7.4 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | |||||
44298982 | 198076 | None | 0 | Rat | Functional | pKd | = | 6.4 | 6.4 | - | 0 | ChEMBL | 445 | 7 | 1 | 6 | 5.2 | CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc(OC)cc1 | 10.1016/S0960-894X(97)00319-3 | |||
CHEMBL55621 | 198076 | None | 0 | Rat | Functional | pKd | = | 6.4 | 6.4 | - | 0 | ChEMBL | 445 | 7 | 1 | 6 | 5.2 | CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc(OC)cc1 | 10.1016/S0960-894X(97)00319-3 | |||
10122442 | 130765 | None | 0 | Rat | Functional | pKd | = | 6.4 | 6.4 | - | 2 | ChEMBL | 660 | 14 | 2 | 11 | 5.6 | CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL368383 | 130765 | None | 0 | Rat | Functional | pKd | = | 6.4 | 6.4 | - | 2 | ChEMBL | 660 | 14 | 2 | 11 | 5.6 | CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
18184194 | 130630 | None | 0 | Rat | Functional | pKd | = | 5.3 | 5.3 | - | 2 | ChEMBL | 712 | 15 | 2 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL368107 | 130630 | None | 0 | Rat | Functional | pKd | = | 5.3 | 5.3 | - | 2 | ChEMBL | 712 | 15 | 2 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | |||
44311345 | 206675 | None | 0 | Rat | Functional | pKd | = | 8.3 | 8.3 | - | 2 | ChEMBL | 663 | 13 | 3 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL70895 | 206675 | None | 0 | Rat | Functional | pKd | = | 8.3 | 8.3 | - | 2 | ChEMBL | 663 | 13 | 3 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
104865 | 706 | None | 60 | Rat | Functional | pKd | = | 7.3 | 7.3 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | |||
104865.0 | 706 | None | 60 | Rat | Functional | pKd | = | 7.3 | 7.3 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | |||
3494 | 706 | None | 60 | Rat | Functional | pKd | = | 7.3 | 7.3 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | |||
392 | 706 | None | 60 | Rat | Functional | pKd | = | 7.3 | 7.3 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL957 | 706 | None | 60 | Rat | Functional | pKd | = | 7.3 | 7.3 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | |||
DB00559 | 706 | None | 60 | Rat | Functional | pKd | = | 7.3 | 7.3 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | |||
10005597 | 119882 | None | 0 | Rat | Functional | pKd | = | 6.3 | 6.3 | 1 | 2 | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | |||
CHEMBL348407 | 119882 | None | 0 | Rat | Functional | pKd | = | 6.3 | 6.3 | 1 | 2 | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | |||
10168597 | 61357 | None | 0 | Rat | Functional | pKd | = | 6.3 | 6.3 | - | 2 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL176741 | 61357 | None | 0 | Rat | Functional | pKd | = | 6.3 | 6.3 | - | 2 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL411171 | 215327 | None | 0 | Pig | Functional | pKd | = | 5.3 | 5.3 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00077a013 | |||||
10233400 | 128753 | None | 0 | Rat | Functional | pKd | = | 7.3 | 7.3 | - | 2 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL366885 | 128753 | None | 0 | Rat | Functional | pKd | = | 7.3 | 7.3 | - | 2 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 | 10.1016/s0960-894x(02)01084-3 | |||
10305334 | 129115 | None | 0 | Rat | Functional | pKd | = | 6.3 | 6.3 | - | 2 | ChEMBL | 680 | 12 | 2 | 11 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL367036 | 129115 | None | 0 | Rat | Functional | pKd | = | 6.3 | 6.3 | - | 2 | ChEMBL | 680 | 12 | 2 | 11 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
192311 | 107330 | None | 1 | Pig | Functional | pKd | = | 7.2 | 7.2 | - | 1 | ChEMBL | 513 | 11 | 5 | 4 | 2.8 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O | 10.1016/0960-894X(95)00221-E | |||
CHEMBL31702 | 107330 | None | 1 | Pig | Functional | pKd | = | 7.2 | 7.2 | - | 1 | ChEMBL | 513 | 11 | 5 | 4 | 2.8 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O | 10.1016/0960-894X(95)00221-E | |||
10457385 | 112751 | None | 0 | Rat | Functional | pKd | = | 6.2 | 6.2 | 85 | 2 | ChEMBL | 469 | 6 | 1 | 8 | 2.5 | Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | |||
CHEMBL330424 | 112751 | None | 0 | Rat | Functional | pKd | = | 6.2 | 6.2 | 85 | 2 | ChEMBL | 469 | 6 | 1 | 8 | 2.5 | Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | |||
11755275 | 202465 | None | 0 | Rat | Functional | pKd | = | 5.2 | 5.2 | -1 | 2 | ChEMBL | 489 | 9 | 1 | 7 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC | 10.1016/S0960-894X(97)00319-3 | |||
CHEMBL59537 | 202465 | None | 0 | Rat | Functional | pKd | = | 5.2 | 5.2 | -1 | 2 | ChEMBL | 489 | 9 | 1 | 7 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC | 10.1016/S0960-894X(97)00319-3 | |||
9831249 | 59717 | None | 0 | Rat | Functional | pKd | = | 6.2 | 6.2 | - | 2 | ChEMBL | 672 | 14 | 2 | 10 | 6.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL172297 | 59717 | None | 0 | Rat | Functional | pKd | = | 6.2 | 6.2 | - | 2 | ChEMBL | 672 | 14 | 2 | 10 | 6.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
10146377 | 60434 | None | 0 | Rat | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 662 | 11 | 2 | 14 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL175058 | 60434 | None | 0 | Rat | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 662 | 11 | 2 | 14 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
44384715 | 60382 | None | 0 | Rat | Functional | pKd | = | 7.2 | 7.2 | - | 2 | ChEMBL | 559 | 9 | 1 | 9 | 5.2 | CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL174607 | 60382 | None | 0 | Rat | Functional | pKd | = | 7.2 | 7.2 | - | 2 | ChEMBL | 559 | 9 | 1 | 9 | 5.2 | CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
104865 | 706 | None | 60 | Rat | Functional | pKd | = | 7.1 | 7.1 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | |||
104865.0 | 706 | None | 60 | Rat | Functional | pKd | = | 7.1 | 7.1 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | |||
3494 | 706 | None | 60 | Rat | Functional | pKd | = | 7.1 | 7.1 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | |||
392 | 706 | None | 60 | Rat | Functional | pKd | = | 7.1 | 7.1 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL957 | 706 | None | 60 | Rat | Functional | pKd | = | 7.1 | 7.1 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | |||
DB00559 | 706 | None | 60 | Rat | Functional | pKd | = | 7.1 | 7.1 | 1 | 5 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | |||
9853077 | 59646 | None | 0 | Rat | Functional | pKd | = | 6.1 | 6.1 | - | 2 | ChEMBL | 696 | 13 | 2 | 12 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL172030 | 59646 | None | 0 | Rat | Functional | pKd | = | 6.1 | 6.1 | - | 2 | ChEMBL | 696 | 13 | 2 | 12 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
9961131 | 132225 | None | 0 | Rat | Functional | pKd | = | 6.1 | 6.1 | - | 2 | ChEMBL | 650 | 15 | 2 | 12 | 3.1 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL369676 | 132225 | None | 0 | Rat | Functional | pKd | = | 6.1 | 6.1 | - | 2 | ChEMBL | 650 | 15 | 2 | 12 | 3.1 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
9830773 | 130294 | None | 0 | Rat | Functional | pKd | = | 7.0 | 7.0 | - | 2 | ChEMBL | 636 | 14 | 2 | 12 | 2.8 | CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL367958 | 130294 | None | 0 | Rat | Functional | pKd | = | 7.0 | 7.0 | - | 2 | ChEMBL | 636 | 14 | 2 | 12 | 2.8 | CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
10096179 | 177125 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCOc1ccc(-c2cc(C)nc(OC(C(=O)O)C(C)(c3ccccc3)c3ccccc3)n2)cc1 | 10.1016/s0960-894x(03)00236-1 | |||
CHEMBL46311 | 177125 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCOc1ccc(-c2cc(C)nc(OC(C(=O)O)C(C)(c3ccccc3)c3ccccc3)n2)cc1 | 10.1016/s0960-894x(03)00236-1 | |||
10070 | 449 | None | 43 | Human | Functional | pA2 | = | 6.7 | 6.7 | 109 | 2 | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | |||
25099191 | 449 | None | 43 | Human | Functional | pA2 | = | 6.7 | 6.7 | 109 | 2 | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | |||
25099191.0 | 449 | None | 43 | Human | Functional | pA2 | = | 6.7 | 6.7 | 109 | 2 | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | |||
CHEMBL2165326 | 449 | None | 43 | Human | Functional | pA2 | = | 6.7 | 6.7 | 109 | 2 | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | |||
DB15059 | 449 | None | 43 | Human | Functional | pA2 | = | 6.7 | 6.7 | 109 | 2 | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | |||
3951 | 391 | None | 55 | Human | Functional | pA2 | = | 7.1 | 7.1 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
4337 | 391 | None | 55 | Human | Functional | pA2 | = | 7.1 | 7.1 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
6918493 | 391 | None | 55 | Human | Functional | pA2 | = | 7.1 | 7.1 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
6918493.0 | 391 | None | 55 | Human | Functional | pA2 | = | 7.1 | 7.1 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
CHEMBL1111 | 391 | None | 55 | Human | Functional | pA2 | = | 7.1 | 7.1 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
DB06403 | 391 | None | 55 | Human | Functional | pA2 | = | 7.1 | 7.1 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
443289 | 711 | None | 39 | Human | Functional | pA2 | = | 7.2 | 7.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
997 | 711 | None | 39 | Human | Functional | pA2 | = | 7.2 | 7.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
CHEMBL314691 | 711 | None | 39 | Human | Functional | pA2 | = | 7.2 | 7.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
DB12054 | 711 | None | 39 | Human | Functional | pA2 | = | 7.2 | 7.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
104865 | 706 | None | 60 | Rat | Functional | pA2 | = | 7.2 | 7.2 | 1 | 5 | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | |||
104865.0 | 706 | None | 60 | Rat | Functional | pA2 | = | 7.2 | 7.2 | 1 | 5 | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | |||
3494 | 706 | None | 60 | Rat | Functional | pA2 | = | 7.2 | 7.2 | 1 | 5 | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | |||
392 | 706 | None | 60 | Rat | Functional | pA2 | = | 7.2 | 7.2 | 1 | 5 | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | |||
CHEMBL957 | 706 | None | 60 | Rat | Functional | pA2 | = | 7.2 | 7.2 | 1 | 5 | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | |||
DB00559 | 706 | None | 60 | Rat | Functional | pA2 | = | 7.2 | 7.2 | 1 | 5 | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | |||
11477084 | 3610 | None | 36 | Human | Functional | pA2 | = | 8 | 8.0 | 58 | 2 | Guide to Pharmacology | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 9171878 | |||
216235 | 3610 | None | 36 | Human | Functional | pA2 | = | 8 | 8.0 | 58 | 2 | Guide to Pharmacology | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 9171878 | |||
3548 | 3610 | None | 36 | Human | Functional | pA2 | = | 8 | 8.0 | 58 | 2 | Guide to Pharmacology | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 9171878 | |||
3950 | 3610 | None | 36 | Human | Functional | pA2 | = | 8 | 8.0 | 58 | 2 | Guide to Pharmacology | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 9171878 | |||
CHEMBL282724 | 3610 | None | 36 | Human | Functional | pA2 | = | 8 | 8.0 | 58 | 2 | Guide to Pharmacology | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 9171878 | |||
DB06268 | 3610 | None | 36 | Human | Functional | pA2 | = | 8 | 8.0 | 58 | 2 | Guide to Pharmacology | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 9171878 | |||
3913 | 3737 | None | 0 | Rat | Functional | pA2 | = | 8.4 | 8.4 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 7780649 | |||||
5311469 | 3737 | None | 0 | Rat | Functional | pA2 | = | 8.4 | 8.4 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 7780649 | |||||
23670447 | 3029 | None | 2 | Human | Functional | pA2 | = | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10066864 | |||
23670447 | 3029 | None | 2 | Human | Functional | pA2 | = | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 9023329 | |||
999 | 3029 | None | 2 | Human | Functional | pA2 | = | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10066864 | |||
999 | 3029 | None | 2 | Human | Functional | pA2 | = | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 9023329 | |||
CHEMBL1204799 | 3029 | None | 2 | Human | Functional | pA2 | = | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10066864 | |||
CHEMBL1204799 | 3029 | None | 2 | Human | Functional | pA2 | = | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 9023329 | |||
CHEMBL25438 | 3029 | None | 2 | Human | Functional | pA2 | = | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10066864 | |||
CHEMBL25438 | 3029 | None | 2 | Human | Functional | pA2 | = | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 9023329 | |||
159594 | 522 | None | 36 | Human | Functional | pA2 | = | 9.2 | 9.2 | 2 | 4 | Guide to Pharmacology | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 8632312 | |||
159594.0 | 522 | None | 36 | Human | Functional | pA2 | = | 9.2 | 9.2 | 2 | 4 | Guide to Pharmacology | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 8632312 | |||
3487 | 522 | None | 36 | Human | Functional | pA2 | = | 9.2 | 9.2 | 2 | 4 | Guide to Pharmacology | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 8632312 | |||
CHEMBL9194 | 522 | None | 36 | Human | Functional | pA2 | = | 9.2 | 9.2 | 2 | 4 | Guide to Pharmacology | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 8632312 | |||
DB06199 | 522 | None | 36 | Human | Functional | pA2 | = | 9.2 | 9.2 | 2 | 4 | Guide to Pharmacology | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 8632312 | |||
12286 | 948 | None | 29 | Human | Functional | pA2 | = | 9.5 | 9.5 | 234 | 2 | Guide to Pharmacology | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 9399983 | |||
6433095 | 948 | None | 29 | Human | Functional | pA2 | = | 9.5 | 9.5 | 234 | 2 | Guide to Pharmacology | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 9399983 | |||
6433095.0 | 948 | None | 29 | Human | Functional | pA2 | = | 9.5 | 9.5 | 234 | 2 | Guide to Pharmacology | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 9399983 | |||
CHEMBL109648 | 948 | None | 29 | Human | Functional | pA2 | = | 9.5 | 9.5 | 234 | 2 | Guide to Pharmacology | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 9399983 | |||
DB06677 | 948 | None | 29 | Human | Functional | pA2 | = | 9.5 | 9.5 | 234 | 2 | Guide to Pharmacology | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 9399983 | |||
5340 | 168833 | None | 66 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | Drug Central | 255 | 3 | 2 | 5 | 1.5 | Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 | None | |||
CHEMBL437 | 168833 | None | 66 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | Drug Central | 255 | 3 | 2 | 5 | 1.5 | Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 | None | |||
6662 | 14452 | None | 40 | Human | Functional | pIC50 | = | 8.2 | 8.2 | -1 | 3 | Drug Central | 309 | 3 | 1 | 6 | 1.6 | CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 | None | |||
CHEMBL1200910 | 14452 | None | 40 | Human | Functional | pIC50 | = | 8.2 | 8.2 | -1 | 3 | Drug Central | 309 | 3 | 1 | 6 | 1.6 | CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 | None | |||
5344 | 173577 | None | 67 | Human | Functional | pIC50 | = | 8.2 | 8.2 | -100 | 6 | Drug Central | 267 | 3 | 2 | 5 | 1.7 | Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C | None | |||
CHEMBL453 | 173577 | None | 67 | Human | Functional | pIC50 | = | 8.2 | 8.2 | -100 | 6 | Drug Central | 267 | 3 | 2 | 5 | 1.7 | Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C | None | |||
8260 | 531 | None | 42 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 141 | 2 | Guide to Pharmacology | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | None | |||
9912992 | 531 | None | 42 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 141 | 2 | Guide to Pharmacology | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | None | |||
CHEMBL3989834 | 531 | None | 42 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 141 | 2 | Guide to Pharmacology | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | None | |||
107810 | 1684 | None | 26 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | 604 | 12 | 4 | 6 | 3.4 | CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C | 7647976 | |||
998 | 1684 | None | 26 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | 604 | 12 | 4 | 6 | 3.4 | CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C | 7647976 | |||
CHEMBL352396 | 1684 | None | 26 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | 604 | 12 | 4 | 6 | 3.4 | CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C | 7647976 | |||
3951 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
4337 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
6918493 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
6918493.0 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
CHEMBL1111 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
DB06403 | 391 | None | 55 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 47 | 2 | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | |||
3539 | 4141 | None | 55 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 424 | 6 | 1 | 9 | 2.7 | COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 | 15956965 | |||
9910224 | 4141 | None | 55 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 424 | 6 | 1 | 9 | 2.7 | COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 | 15956965 | |||
9910224.0 | 4141 | None | 55 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 424 | 6 | 1 | 9 | 2.7 | COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 | 15956965 | |||
CHEMBL1628688 | 4141 | None | 55 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 424 | 6 | 1 | 9 | 2.7 | COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 | 15956965 | |||
DB06629 | 4141 | None | 55 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 424 | 6 | 1 | 9 | 2.7 | COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 | 15956965 | |||
10070 | 449 | None | 43 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 109 | 2 | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | |||
25099191 | 449 | None | 43 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 109 | 2 | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | |||
25099191.0 | 449 | None | 43 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 109 | 2 | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | |||
CHEMBL2165326 | 449 | None | 43 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 109 | 2 | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | |||
DB15059 | 449 | None | 43 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 109 | 2 | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | |||
1000 | 3503 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | Guide to Pharmacology | 614 | 14 | 2 | 9 | 6.1 | CCCCn1ncc(c1c1ccc(cc1OCc1ccccc1C(=O)O)OC)/C=C(/C(=O)O)\Cc1cc2OCOc2cc1OC | 9694916 | |||
5311425 | 3503 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | Guide to Pharmacology | 614 | 14 | 2 | 9 | 6.1 | CCCCn1ncc(c1c1ccc(cc1OCc1ccccc1C(=O)O)OC)/C=C(/C(=O)O)\Cc1cc2OCOc2cc1OC | 9694916 | |||
CHEMBL1628624 | 3503 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | Guide to Pharmacology | 614 | 14 | 2 | 9 | 6.1 | CCCCn1ncc(c1c1ccc(cc1OCc1ccccc1C(=O)O)OC)/C=C(/C(=O)O)\Cc1cc2OCOc2cc1OC | 9694916 | |||
16004692 | 2454 | None | 59 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 107 | 2 | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | |||
16004692.0 | 2454 | None | 59 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 107 | 2 | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | |||
4809 | 2454 | None | 59 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 107 | 2 | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | |||
7352 | 2454 | None | 59 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 107 | 2 | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | |||
CHEMBL2103873 | 2454 | None | 59 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 107 | 2 | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | |||
DB08932 | 2454 | None | 59 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 107 | 2 | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | |||
131845706 | 3472 | None | 5 | Human | Functional | pIC50 | None | 7.8 | 7.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
71308726 | 3472 | None | 5 | Human | Functional | pIC50 | None | 7.8 | 7.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
995 | 3472 | None | 5 | Human | Functional | pIC50 | None | 7.8 | 7.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
CHEMBL1222310 | 3472 | None | 5 | Human | Functional | pIC50 | None | 7.8 | 7.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
CHEMBL4524099 | 3472 | None | 5 | Human | Functional | pIC50 | None | 7.8 | 7.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
101598716 | 1562 | None | 26 | Human | Functional | pIC50 | None | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
16133807 | 1562 | None | 26 | Human | Functional | pIC50 | None | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
16212950 | 1562 | None | 26 | Human | Functional | pIC50 | None | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
989 | 1562 | None | 26 | Human | Functional | pIC50 | None | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
CHEMBL3775234 | 1562 | None | 26 | Human | Functional | pIC50 | None | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
16133808 | 1563 | None | 0 | Human | Functional | pIC50 | None | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
16219332 | 1563 | None | 0 | Human | Functional | pIC50 | None | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
56947103 | 1563 | None | 0 | Human | Functional | pIC50 | None | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
990 | 1563 | None | 0 | Human | Functional | pIC50 | None | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
CHEMBL3774897 | 1563 | None | 0 | Human | Functional | pIC50 | None | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 7647976 | |||||
108002 | 3494 | None | 22 | Rat | Functional | pKB | = | 9.4 | 9.4 | -1 | 2 | Guide to Pharmacology | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 8201588 | |||
3528 | 3494 | None | 22 | Rat | Functional | pKB | = | 9.4 | 9.4 | -1 | 2 | Guide to Pharmacology | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 8201588 | |||
CHEMBL8823 | 3494 | None | 22 | Rat | Functional | pKB | = | 9.4 | 9.4 | -1 | 2 | Guide to Pharmacology | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 8201588 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
28230148 | 208189 | None | 59 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 320 | 3 | 2 | 6 | 0.7 | CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 | 10.1038/s41467-023-40064-9 | |||
3229 | 208189 | None | 59 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 320 | 3 | 2 | 6 | 0.7 | CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 | 10.1038/s41467-023-40064-9 | |||
CHEMBL826 | 208189 | None | 59 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 320 | 3 | 2 | 6 | 0.7 | CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 | 10.1038/s41467-023-40064-9 | |||
41684 | 31229 | None | 62 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1401 | 31229 | None | 62 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
54677470 | 203007 | None | 67 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 30 | ChEMBL | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1256873 | 203007 | None | 67 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 30 | ChEMBL | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL599 | 203007 | None | 67 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 30 | ChEMBL | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | 10.1038/s41467-023-40064-9 | |||
4829 | 202412 | None | 64 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 356 | 7 | 1 | 5 | 3.2 | CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL595 | 202412 | None | 64 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 356 | 7 | 1 | 5 | 3.2 | CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 | 10.1038/s41467-023-40064-9 | |||
104865 | 706 | None | 60 | Human | Binding | pAC50 | = | 7.5 | 7.5 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | |||
104865.0 | 706 | None | 60 | Human | Binding | pAC50 | = | 7.5 | 7.5 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | |||
3494 | 706 | None | 60 | Human | Binding | pAC50 | = | 7.5 | 7.5 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | |||
392 | 706 | None | 60 | Human | Binding | pAC50 | = | 7.5 | 7.5 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL957 | 706 | None | 60 | Human | Binding | pAC50 | = | 7.5 | 7.5 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | |||
DB00559 | 706 | None | 60 | Human | Binding | pAC50 | = | 7.5 | 7.5 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | |||
1209 | 1658 | None | 52 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 31 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.1038/s41467-023-40064-9 | |||
203 | 1658 | None | 52 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 31 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.1038/s41467-023-40064-9 | |||
3386 | 1658 | None | 52 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 31 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.1038/s41467-023-40064-9 | |||
CHEMBL41 | 1658 | None | 52 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 31 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.1038/s41467-023-40064-9 | |||
DB00472 | 1658 | None | 52 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 31 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.1038/s41467-023-40064-9 | |||
5329102 | 194838 | None | 50 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
CHEMBL535 | 194838 | None | 50 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
135398513 | 66140 | None | 73 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 225 | 4 | 3 | 8 | -0.9 | Nc1nc(O)c2ncn(COCCO)c2n1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL184 | 66140 | None | 73 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 225 | 4 | 3 | 8 | -0.9 | Nc1nc(O)c2ncn(COCCO)c2n1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL2370066 | 212236 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
CHEMBL315841 | 213652 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00070a001 | |||||
CHEMBL2370067 | 212237 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@H](C=O)Cc1c[nH]c2ccccc12)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
CHEMBL407269 | 215111 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
CHEMBL313344 | 213571 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
CHEMBL387200 | 214868 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
CHEMBL86703 | 218379 | None | 0 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C | 10.1021/jm00070a001 | |||||
44284437 | 100038 | None | 0 | Human | Binding | pIC50 | = | 11.0 | 11.0 | - | 0 | ChEMBL | 520 | 9 | 4 | 8 | 3.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL286621 | 100038 | None | 0 | Human | Binding | pIC50 | = | 11.0 | 11.0 | - | 0 | ChEMBL | 520 | 9 | 4 | 8 | 3.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
44284405 | 100410 | None | 0 | Human | Binding | pIC50 | = | 11.0 | 11.0 | - | 0 | ChEMBL | 532 | 10 | 2 | 7 | 5.4 | COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL289634 | 100410 | None | 0 | Human | Binding | pIC50 | = | 11.0 | 11.0 | - | 0 | ChEMBL | 532 | 10 | 2 | 7 | 5.4 | COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
44284287 | 161341 | None | 0 | Human | Binding | pIC50 | = | 11.0 | 11.0 | - | 0 | ChEMBL | 532 | 10 | 3 | 7 | 5.2 | CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL411925 | 161341 | None | 0 | Human | Binding | pIC50 | = | 11.0 | 11.0 | - | 0 | ChEMBL | 532 | 10 | 3 | 7 | 5.2 | CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
11017304 | 114204 | None | 0 | Pig | Binding | pIC50 | = | 10.9 | 10.9 | - | 0 | ChEMBL | 579 | 11 | 1 | 9 | 5.8 | CCc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL332922 | 114204 | None | 0 | Pig | Binding | pIC50 | = | 10.9 | 10.9 | - | 0 | ChEMBL | 579 | 11 | 1 | 9 | 5.8 | CCc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)cc1 | 10.1021/jm0102304 | |||
44284288 | 100189 | None | 0 | Human | Binding | pIC50 | = | 10.9 | 10.9 | - | 0 | ChEMBL | 559 | 9 | 2 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL287683 | 100189 | None | 0 | Human | Binding | pIC50 | = | 10.9 | 10.9 | - | 0 | ChEMBL | 559 | 9 | 2 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | |||
44284292 | 168215 | None | 0 | Human | Binding | pIC50 | = | 10.9 | 10.9 | - | 0 | ChEMBL | 518 | 8 | 3 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)(C)O)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL432856 | 168215 | None | 0 | Human | Binding | pIC50 | = | 10.9 | 10.9 | - | 0 | ChEMBL | 518 | 8 | 3 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)(C)O)c1 | 10.1016/j.bmcl.2004.01.008 | |||
9852318 | 9616 | None | 8 | Rat | Binding | pIC50 | = | 10.8 | 10.8 | - | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL112624 | 9616 | None | 8 | Rat | Binding | pIC50 | = | 10.8 | 10.8 | - | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL1627022 | 9616 | None | 8 | Rat | Binding | pIC50 | = | 10.8 | 10.8 | - | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
11082446 | 9913 | None | 0 | Pig | Binding | pIC50 | = | 10.8 | 10.8 | - | 0 | ChEMBL | 581 | 12 | 1 | 11 | 4.6 | COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2Oc2cccc(OC)c2)nc1 | 10.1021/jm0102304 | |||
CHEMBL114380 | 9913 | None | 0 | Pig | Binding | pIC50 | = | 10.8 | 10.8 | - | 0 | ChEMBL | 581 | 12 | 1 | 11 | 4.6 | COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2Oc2cccc(OC)c2)nc1 | 10.1021/jm0102304 | |||
10897569 | 10142 | None | 0 | Pig | Binding | pIC50 | = | 10.7 | 10.7 | - | 0 | ChEMBL | 645 | 11 | 1 | 10 | 5.7 | COc1ccccc1Sc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(Br)cn1 | 10.1021/jm0102304 | |||
CHEMBL115724 | 10142 | None | 0 | Pig | Binding | pIC50 | = | 10.7 | 10.7 | - | 0 | ChEMBL | 645 | 11 | 1 | 10 | 5.7 | COc1ccccc1Sc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(Br)cn1 | 10.1021/jm0102304 | |||
10227760 | 101041 | None | 0 | Human | Binding | pIC50 | = | 10.7 | 10.7 | - | 0 | ChEMBL | 481 | 6 | 2 | 7 | 4.9 | CC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL294291 | 101041 | None | 0 | Human | Binding | pIC50 | = | 10.7 | 10.7 | - | 0 | ChEMBL | 481 | 6 | 2 | 7 | 4.9 | CC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
10163017 | 203237 | None | 0 | Human | Binding | pIC50 | = | 10.7 | 10.7 | - | 0 | ChEMBL | 482 | 6 | 3 | 8 | 4.6 | C/C(=N\O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL60058 | 203237 | None | 0 | Human | Binding | pIC50 | = | 10.7 | 10.7 | - | 0 | ChEMBL | 482 | 6 | 3 | 8 | 4.6 | C/C(=N\O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
44284236 | 122389 | None | 0 | Human | Binding | pIC50 | = | 10.7 | 10.7 | - | 0 | ChEMBL | 504 | 9 | 3 | 7 | 4.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCCO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL35984 | 122389 | None | 0 | Human | Binding | pIC50 | = | 10.7 | 10.7 | - | 0 | ChEMBL | 504 | 9 | 3 | 7 | 4.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCCO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
72548703 | 161661 | None | 0 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
CHEMBL4128926 | 161661 | None | 0 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
101598716 | 1562 | None | 26 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
16133807 | 1562 | None | 26 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
16212950 | 1562 | None | 26 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
989 | 1562 | None | 26 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
CHEMBL3775234 | 1562 | None | 26 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
101598716 | 1562 | None | 26 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
16133807 | 1562 | None | 26 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
16212950 | 1562 | None | 26 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
989 | 1562 | None | 26 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
CHEMBL3775234 | 1562 | None | 26 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
44284288 | 100189 | None | 0 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 559 | 9 | 2 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL287683 | 100189 | None | 0 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 559 | 9 | 2 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | |||
44284405 | 100410 | None | 0 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 532 | 10 | 2 | 7 | 5.4 | COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL289634 | 100410 | None | 0 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 532 | 10 | 2 | 7 | 5.4 | COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
9873636 | 173928 | None | 0 | Rat | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 607 | 10 | 1 | 10 | 6.4 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cc3ccccc3s2)nc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4538570 | 173928 | None | 0 | Rat | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 607 | 10 | 1 | 10 | 6.4 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cc3ccccc3s2)nc1 | 10.1016/j.bmcl.2016.06.014 | |||
44381151 | 59407 | None | 0 | Pig | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 671 | 13 | 1 | 10 | 6.3 | CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 | 10.1016/s0960-894x(01)00682-5 | |||
CHEMBL170908 | 59407 | None | 0 | Pig | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 671 | 13 | 1 | 10 | 6.3 | CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 | 10.1016/s0960-894x(01)00682-5 | |||
44284266 | 137019 | None | 0 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 531 | 8 | 2 | 7 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CN(C)C(C)=O)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL37427 | 137019 | None | 0 | Human | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 531 | 8 | 2 | 7 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CN(C)C(C)=O)c1 | 10.1016/j.bmcl.2004.01.008 | |||
11039156 | 10072 | None | 0 | Pig | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 581 | 11 | 1 | 10 | 5.2 | COc1cccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)c1 | 10.1021/jm0102304 | |||
CHEMBL115333 | 10072 | None | 0 | Pig | Binding | pIC50 | = | 10.6 | 10.6 | - | 0 | ChEMBL | 581 | 11 | 1 | 10 | 5.2 | COc1cccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)c1 | 10.1021/jm0102304 | |||
10206855 | 100956 | None | 0 | Human | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 493 | 7 | 2 | 7 | 5.0 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CC2)c1 | 10.1021/jm030528p | |||
CHEMBL293830 | 100956 | None | 0 | Human | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 493 | 7 | 2 | 7 | 5.0 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CC2)c1 | 10.1021/jm030528p | |||
10185556 | 102711 | None | 0 | Human | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 503 | 6 | 2 | 8 | 3.8 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(C)(=O)=O)c1 | 10.1021/jm030528p | |||
CHEMBL304460 | 102711 | None | 0 | Human | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 503 | 6 | 2 | 8 | 3.8 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(C)(=O)=O)c1 | 10.1021/jm030528p | |||
10228523 | 203687 | None | 0 | Human | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 495 | 7 | 2 | 7 | 5.3 | CCC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL60367 | 203687 | None | 0 | Human | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 495 | 7 | 2 | 7 | 5.3 | CCC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
44284238 | 100181 | None | 0 | Human | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 490 | 8 | 3 | 7 | 4.2 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL287622 | 100181 | None | 0 | Human | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 490 | 8 | 3 | 7 | 4.2 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
10152810 | 14792 | None | 2 | Rat | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 538 | 10 | 1 | 9 | 4.8 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL1206706 | 14792 | None | 2 | Rat | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 538 | 10 | 1 | 9 | 4.8 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL298725 | 14792 | None | 2 | Rat | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 538 | 10 | 1 | 9 | 4.8 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F | 10.1016/s0960-894x(98)00301-1 | |||
159594 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.5 | 10.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm970101g | |||
159594.0 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.5 | 10.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm970101g | |||
3487 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.5 | 10.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm970101g | |||
CHEMBL9194 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.5 | 10.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm970101g | |||
DB06199 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.5 | 10.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm970101g | |||
10962637 | 10081 | None | 0 | Rat | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 549 | 10 | 2 | 9 | 4.3 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 | 10.1021/jm000538f | |||
CHEMBL115372 | 10081 | None | 0 | Rat | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 549 | 10 | 2 | 9 | 4.3 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 | 10.1021/jm000538f | |||
CHEMBL1627023 | 10081 | None | 0 | Rat | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 549 | 10 | 2 | 9 | 4.3 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 | 10.1021/jm000538f | |||
159594 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.5 | 10.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990171i | |||
159594.0 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.5 | 10.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990171i | |||
3487 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.5 | 10.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990171i | |||
CHEMBL9194 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.5 | 10.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990171i | |||
DB06199 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.5 | 10.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990171i | |||
11767155 | 11745 | None | 0 | Pig | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 596 | 10 | 1 | 9 | 5.9 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccccn3)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL1181545 | 11745 | None | 0 | Pig | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 596 | 10 | 1 | 9 | 5.9 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccccn3)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL177173 | 11745 | None | 0 | Pig | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 596 | 10 | 1 | 9 | 5.9 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccccn3)cn2)cc1 | 10.1021/jm0102304 | |||
44284041 | 100357 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 520 | 9 | 3 | 8 | 4.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL289216 | 100357 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 520 | 9 | 3 | 8 | 4.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
9938571 | 9599 | None | 0 | Rat | Binding | pIC50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | |||
CHEMBL112531 | 9599 | None | 0 | Rat | Binding | pIC50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | |||
CHEMBL369489 | 9599 | None | 0 | Rat | Binding | pIC50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | |||
9938571 | 9599 | None | 0 | Rat | Binding | pIC50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL112531 | 9599 | None | 0 | Rat | Binding | pIC50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL369489 | 9599 | None | 0 | Rat | Binding | pIC50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
10187997 | 110028 | None | 0 | Rat | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm031041j | |||
CHEMBL323464 | 110028 | None | 0 | Rat | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm031041j | |||
11828009 | 9893 | None | 0 | Pig | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 581 | 11 | 2 | 10 | 4.7 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(CO)cc2)nc1 | 10.1021/jm000538f | |||
CHEMBL114298 | 9893 | None | 0 | Pig | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 581 | 11 | 2 | 10 | 4.7 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(CO)cc2)nc1 | 10.1021/jm000538f | |||
11966523 | 110426 | None | 0 | Pig | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 613 | 10 | 2 | 9 | 4.7 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(CO)cc2)cc1 | 10.1021/jm000538f | |||
CHEMBL324184 | 110426 | None | 0 | Pig | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 613 | 10 | 2 | 9 | 4.7 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(CO)cc2)cc1 | 10.1021/jm000538f | |||
9934302 | 72669 | None | 1 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 467 | 6 | 2 | 7 | 4.6 | CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL19950 | 72669 | None | 1 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 467 | 6 | 2 | 7 | 4.6 | CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
11752337 | 162322 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 496 | 7 | 2 | 8 | 4.7 | CO/N=C(\C)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL416324 | 162322 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 496 | 7 | 2 | 8 | 4.7 | CO/N=C(\C)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
23445355 | 203359 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 469 | 6 | 2 | 8 | 3.8 | COC(=O)c1cc(C)ccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL60149 | 203359 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 469 | 6 | 2 | 8 | 3.8 | COC(=O)c1cc(C)ccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
9934302 | 72669 | None | 1 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 467 | 6 | 2 | 7 | 4.6 | CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm000349x | |||
CHEMBL19950 | 72669 | None | 1 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 467 | 6 | 2 | 7 | 4.6 | CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm000349x | |||
44284115 | 100249 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 518 | 9 | 3 | 7 | 4.8 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL288247 | 100249 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 518 | 9 | 3 | 7 | 4.8 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
44381125 | 59307 | None | 0 | Pig | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 674 | 10 | 1 | 9 | 6.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(-c3ccccn3)nc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/s0960-894x(01)00682-5 | |||
CHEMBL170493 | 59307 | None | 0 | Pig | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 674 | 10 | 1 | 9 | 6.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(-c3ccccn3)nc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/s0960-894x(01)00682-5 | |||
10187997 | 110028 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL323464 | 110028 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
44284287 | 161341 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 532 | 10 | 3 | 7 | 5.2 | CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL411925 | 161341 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 0 | ChEMBL | 532 | 10 | 3 | 7 | 5.2 | CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
44284481 | 216186 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/np900287e | |||||
CHEMBL437472 | 216186 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/np900287e | |||||
44284328 | 127608 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 476 | 7 | 2 | 7 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL36627 | 127608 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 476 | 7 | 2 | 7 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC)c1 | 10.1016/j.bmcl.2004.01.008 | |||
44284437 | 100038 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 520 | 9 | 4 | 8 | 3.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL286621 | 100038 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 520 | 9 | 4 | 8 | 3.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
44386450 | 62418 | None | 0 | Rat | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 606 | 15 | 1 | 10 | 5.1 | COC(=O)CCCCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OC)c1OC | 10.1021/jm031041j | |||
CHEMBL177973 | 62418 | None | 0 | Rat | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 606 | 15 | 1 | 10 | 5.1 | COC(=O)CCCCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OC)c1OC | 10.1021/jm031041j | |||
44284481 | 216186 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.ejmech.2013.01.044 | |||||
CHEMBL437472 | 216186 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.ejmech.2013.01.044 | |||||
10143256 | 100628 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 531 | 7 | 2 | 8 | 4.6 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(=O)(=O)C(C)C)c1 | 10.1021/jm030528p | |||
CHEMBL291592 | 100628 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 531 | 7 | 2 | 8 | 4.6 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(=O)(=O)C(C)C)c1 | 10.1021/jm030528p | |||
10183338 | 205243 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 464 | 5 | 2 | 7 | 4.5 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C#N)c1C | 10.1021/jm030528p | |||
CHEMBL62159 | 205243 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 464 | 5 | 2 | 7 | 4.5 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C#N)c1C | 10.1021/jm030528p | |||
10722385 | 100553 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 606 | 13 | 1 | 11 | 4.6 | COC(=O)CCCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | |||
CHEMBL291058 | 100553 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 606 | 13 | 1 | 11 | 4.6 | COC(=O)CCCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | |||
11006709 | 9959 | None | 0 | Pig | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 629 | 11 | 1 | 10 | 5.4 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1016/s0960-894x(01)00682-5 | |||
CHEMBL114700 | 9959 | None | 0 | Pig | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 629 | 11 | 1 | 10 | 5.4 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1016/s0960-894x(01)00682-5 | |||
11006709 | 9959 | None | 0 | Pig | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 629 | 11 | 1 | 10 | 5.4 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1021/jm0102304 | |||
CHEMBL114700 | 9959 | None | 0 | Pig | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 629 | 11 | 1 | 10 | 5.4 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1021/jm0102304 | |||
10651488 | 163474 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | |||
CHEMBL419367 | 163474 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | |||
159594 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.3 | 10.3 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/acs.jmedchem.5b01781 | |||
159594.0 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.3 | 10.3 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/acs.jmedchem.5b01781 | |||
3487 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.3 | 10.3 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/acs.jmedchem.5b01781 | |||
CHEMBL9194 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.3 | 10.3 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/acs.jmedchem.5b01781 | |||
DB06199 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.3 | 10.3 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/acs.jmedchem.5b01781 | |||
44284041 | 100357 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 520 | 9 | 3 | 8 | 4.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL289216 | 100357 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 520 | 9 | 3 | 8 | 4.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
11734600 | 10012 | None | 0 | Pig | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 585 | 11 | 1 | 10 | 5.3 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)c1 | 10.1021/jm0102304 | |||
CHEMBL114964 | 10012 | None | 0 | Pig | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 585 | 11 | 1 | 10 | 5.3 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)c1 | 10.1021/jm0102304 | |||
44284115 | 100249 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 518 | 9 | 3 | 7 | 4.8 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL288247 | 100249 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 518 | 9 | 3 | 7 | 4.8 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
10119327 | 205213 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 531 | 8 | 2 | 8 | 4.6 | CCCS(=O)(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL62019 | 205213 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 531 | 8 | 2 | 8 | 4.6 | CCCS(=O)(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
10206155 | 205233 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 481 | 7 | 2 | 7 | 5.0 | CCC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL62112 | 205233 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 481 | 7 | 2 | 7 | 5.0 | CCC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
10344914 | 100191 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 476 | 7 | 3 | 7 | 4.1 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL287711 | 100191 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 476 | 7 | 3 | 7 | 4.1 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CO)c1 | 10.1016/j.bmcl.2004.01.008 | |||
44284391 | 139388 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 532 | 9 | 3 | 7 | 5.3 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCC(C)(C)O)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL37920 | 139388 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 532 | 9 | 3 | 7 | 5.3 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCC(C)(C)O)c1 | 10.1016/j.bmcl.2004.01.008 | |||
10119177 | 117529 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 528 | 12 | 1 | 6 | 4.8 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm010237l | |||
CHEMBL339904 | 117529 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 528 | 12 | 1 | 6 | 4.8 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm010237l | |||
10603409 | 110667 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | |||
CHEMBL325581 | 110667 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | |||
10228588 | 101913 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 496 | 6 | 2 | 7 | 4.1 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)C)c1 | 10.1021/jm030528p | |||
CHEMBL300577 | 101913 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 496 | 6 | 2 | 7 | 4.1 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)C)c1 | 10.1021/jm030528p | |||
10210629 | 8766 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL109644 | 8766 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
9916235 | 9355 | None | 1 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL111277 | 9355 | None | 1 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
159594 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990170q | |||
159594.0 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990170q | |||
3487 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990170q | |||
CHEMBL9194 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990170q | |||
DB06199 | 522 | None | 36 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990170q | |||
9916235 | 9355 | None | 1 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm990170q | |||
CHEMBL111277 | 9355 | None | 1 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm990170q | |||
10278217 | 101825 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 492 | 6 | 2 | 8 | 5.0 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ncco2)c1 | 10.1021/jm030528p | |||
CHEMBL299921 | 101825 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 492 | 6 | 2 | 8 | 5.0 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ncco2)c1 | 10.1021/jm030528p | |||
9911482 | 168176 | None | 20 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 447 | 6 | 2 | 7 | 4.2 | CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm030528p | |||
CHEMBL432521 | 168176 | None | 20 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 447 | 6 | 2 | 7 | 4.2 | CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm030528p | |||
10114414 | 201278 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 444 | 5 | 2 | 7 | 4.2 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C#N)c1C | 10.1021/jm030528p | |||
CHEMBL58359 | 201278 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 444 | 5 | 2 | 7 | 4.2 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C#N)c1C | 10.1021/jm030528p | |||
11766844 | 109837 | None | 0 | Rat | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 553 | 9 | 1 | 8 | 5.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL176272 | 109837 | None | 0 | Rat | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 553 | 9 | 1 | 8 | 5.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL323243 | 109837 | None | 0 | Rat | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 553 | 9 | 1 | 8 | 5.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 | 10.1021/jm0102304 | |||
159594 | 522 | None | 36 | Rat | Binding | pIC50 | = | 10.1 | 10.1 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | |||
159594.0 | 522 | None | 36 | Rat | Binding | pIC50 | = | 10.1 | 10.1 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | |||
3487 | 522 | None | 36 | Rat | Binding | pIC50 | = | 10.1 | 10.1 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | |||
CHEMBL9194 | 522 | None | 36 | Rat | Binding | pIC50 | = | 10.1 | 10.1 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | |||
DB06199 | 522 | None | 36 | Rat | Binding | pIC50 | = | 10.1 | 10.1 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | |||
10115469 | 100892 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 459 | 5 | 2 | 6 | 5.0 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(Cl)c1 | 10.1021/jm030528p | |||
CHEMBL293398 | 100892 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 459 | 5 | 2 | 6 | 5.0 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(Cl)c1 | 10.1021/jm030528p | |||
10627272 | 206514 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 592 | 12 | 1 | 11 | 4.2 | COC(=O)CCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | |||
CHEMBL69986 | 206514 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 592 | 12 | 1 | 11 | 4.2 | COC(=O)CCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | |||
10603409 | 110667 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | |||
CHEMBL325581 | 110667 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | |||
10187997 | 110028 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL323464 | 110028 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
21041278 | 171880 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 554 | 12 | 2 | 9 | 3.5 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4467748 | 171880 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 554 | 12 | 2 | 9 | 3.5 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
10165963 | 102904 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 545 | 8 | 2 | 9 | 3.6 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)CS(C)(=O)=O)c1 | 10.1021/jm030528p | |||
CHEMBL305602 | 102904 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 545 | 8 | 2 | 9 | 3.6 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)CS(C)(=O)=O)c1 | 10.1021/jm030528p | |||
10366278 | 172567 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 446 | 6 | 2 | 6 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL448165 | 172567 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 446 | 6 | 2 | 6 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
10624511 | 71762 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 478 | 6 | 2 | 7 | 4.7 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2noc(C)c2Cl)c(C)c1CC#N | 10.1021/jm000349x | |||
CHEMBL19661 | 71762 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 478 | 6 | 2 | 7 | 4.7 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2noc(C)c2Cl)c(C)c1CC#N | 10.1021/jm000349x | |||
10210629 | 8766 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL109644 | 8766 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
11827657 | 19388 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 540 | 13 | 1 | 7 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 | 10.1021/jm010237l | |||
CHEMBL129220 | 19388 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 540 | 13 | 1 | 7 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 | 10.1021/jm010237l | |||
44284481 | 216186 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.bmc.2013.03.016 | |||||
CHEMBL437472 | 216186 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.bmc.2013.03.016 | |||||
44302615 | 202880 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 497 | 7 | 2 | 8 | 4.6 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)OC(C)C)c1 | 10.1021/jm030528p | |||
CHEMBL59819 | 202880 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 497 | 7 | 2 | 8 | 4.6 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)OC(C)C)c1 | 10.1021/jm030528p | |||
25211074 | 18492 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 543 | 10 | 2 | 7 | 5.1 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | |||
CHEMBL1272244 | 18492 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 543 | 10 | 2 | 7 | 5.1 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | |||
11016761 | 109079 | None | 0 | Pig | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 519 | 9 | 1 | 8 | 4.8 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL321242 | 109079 | None | 0 | Pig | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 519 | 9 | 1 | 8 | 4.8 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)cc1 | 10.1021/jm0102304 | |||
44284329 | 100466 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 504 | 8 | 2 | 7 | 5.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL290181 | 100466 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 504 | 8 | 2 | 7 | 5.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | |||
9914310 | 209101 | None | 9 | Human | Binding | pIC50 | = | 10.0 | 10.0 | 1995 | 2 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL8923 | 209101 | None | 9 | Human | Binding | pIC50 | = | 10.0 | 10.0 | 1995 | 2 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
10768977 | 61868 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 548 | 13 | 1 | 8 | 5.6 | CCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OCC)c1OCC | 10.1021/jm031041j | |||
CHEMBL177378 | 61868 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 548 | 13 | 1 | 8 | 5.6 | CCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OCC)c1OCC | 10.1021/jm031041j | |||
44352079 | 116605 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 494 | 11 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 | 10.1021/jm010237l | |||
CHEMBL336272 | 116605 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 494 | 11 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 | 10.1021/jm010237l | |||
10674176 | 162795 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 548 | 11 | 1 | 9 | 5.0 | CCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OCC)c1OCC | 10.1021/jm9606507 | |||
CHEMBL417067 | 162795 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 548 | 11 | 1 | 9 | 5.0 | CCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OCC)c1OCC | 10.1021/jm9606507 | |||
44334146 | 168103 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 446 | 7 | 2 | 6 | 4.6 | CCCNc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL432012 | 168103 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 446 | 7 | 2 | 6 | 4.6 | CCCNc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
10163744 | 98768 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 495 | 7 | 2 | 7 | 5.2 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C(C)C)c1 | 10.1021/jm000349x | |||
CHEMBL277706 | 98768 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 495 | 7 | 2 | 7 | 5.2 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C(C)C)c1 | 10.1021/jm000349x | |||
9916235 | 9355 | None | 1 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL111277 | 9355 | None | 1 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
11465535 | 203528 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 468 | 6 | 3 | 7 | 3.5 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 | 10.1021/jm030528p | |||
CHEMBL60276 | 203528 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 468 | 6 | 3 | 7 | 3.5 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 | 10.1021/jm030528p | |||
10277399 | 66887 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 478 | 6 | 2 | 7 | 4.7 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1CC#N | 10.1021/jm000349x | |||
CHEMBL18626 | 66887 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 478 | 6 | 2 | 7 | 4.7 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1CC#N | 10.1021/jm000349x | |||
10139080 | 72592 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 454 | 6 | 2 | 7 | 4.6 | Cc1cc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O | 10.1021/jm000349x | |||
CHEMBL19921 | 72592 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 454 | 6 | 2 | 7 | 4.6 | Cc1cc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O | 10.1021/jm000349x | |||
10717923 | 98747 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 439 | 5 | 2 | 6 | 4.7 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm030528p | |||
CHEMBL277595 | 98747 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 439 | 5 | 2 | 6 | 4.7 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm030528p | |||
9810351 | 58098 | None | 0 | Pig | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 705 | 14 | 2 | 12 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCO)nc1OCCOc1ncc(Br)cn1 | 10.1016/s0960-894x(01)00682-5 | |||
CHEMBL167314 | 58098 | None | 0 | Pig | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 705 | 14 | 2 | 12 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCO)nc1OCCOc1ncc(Br)cn1 | 10.1016/s0960-894x(01)00682-5 | |||
44284481 | 216186 | None | 0 | Pig | Binding | pIC50 | = | 9.8 | 9.8 | -3 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00077a013 | |||||
CHEMBL437472 | 216186 | None | 0 | Pig | Binding | pIC50 | = | 9.8 | 9.8 | -3 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00077a013 | |||||
9936145 | 19034 | None | 2 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 510 | 11 | 1 | 4 | 5.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 | 10.1021/jm010237l | |||
CHEMBL128818 | 19034 | None | 2 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 510 | 11 | 1 | 4 | 5.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 | 10.1021/jm010237l | |||
44284481 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm8007618 | |||||
CHEMBL437472 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm8007618 | |||||
11731472 | 9514 | None | 0 | Pig | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 571 | 10 | 1 | 10 | 5.6 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)s2)nc1 | 10.1021/jm0102304 | |||
CHEMBL112141 | 9514 | None | 0 | Pig | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 571 | 10 | 1 | 10 | 5.6 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)s2)nc1 | 10.1021/jm0102304 | |||
11050163 | 11748 | None | 0 | Pig | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 583 | 10 | 1 | 8 | 5.4 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL1181553 | 11748 | None | 0 | Pig | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 583 | 10 | 1 | 8 | 5.4 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL177924 | 11748 | None | 0 | Pig | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 583 | 10 | 1 | 8 | 5.4 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
44351968 | 118144 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 508 | 12 | 1 | 5 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 | 10.1021/jm010237l | |||
CHEMBL340575 | 118144 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 508 | 12 | 1 | 5 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 | 10.1021/jm010237l | |||
10717923 | 98747 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 439 | 5 | 2 | 6 | 4.7 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm000349x | |||
CHEMBL277595 | 98747 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 439 | 5 | 2 | 6 | 4.7 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm000349x | |||
10623757 | 98985 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 458 | 6 | 2 | 7 | 4.4 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1CC#N | 10.1021/jm000349x | |||
CHEMBL279471 | 98985 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 458 | 6 | 2 | 7 | 4.4 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1CC#N | 10.1021/jm000349x | |||
9806559 | 9152 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 515 | 13 | 1 | 6 | 3.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O | 10.1021/jm980217s | |||
CHEMBL110053 | 9152 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 515 | 13 | 1 | 6 | 3.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O | 10.1021/jm980217s | |||
9936145 | 19034 | None | 2 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 510 | 11 | 1 | 4 | 5.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 | 10.1021/jm010237l | |||
CHEMBL128818 | 19034 | None | 2 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 510 | 11 | 1 | 4 | 5.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 | 10.1021/jm010237l | |||
CHEMBL1790959 | 211367 | None | 0 | Pig | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | |||||
9825494 | 205067 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm031041j | |||
CHEMBL61211 | 205067 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm031041j | |||
9825494 | 205067 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL61211 | 205067 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
9825494 | 205067 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/acs.jmedchem.5b01781 | |||
CHEMBL61211 | 205067 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/acs.jmedchem.5b01781 | |||
9868637 | 99142 | None | 1 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 455 | 5 | 3 | 7 | 4.4 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O | 10.1021/jm000349x | |||
CHEMBL280659 | 99142 | None | 1 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 455 | 5 | 3 | 7 | 4.4 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O | 10.1021/jm000349x | |||
CHEMBL1790963 | 211370 | None | 0 | Pig | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | |||||
11757759 | 174550 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 570 | 13 | 2 | 10 | 2.8 | COCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4553625 | 174550 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 570 | 13 | 2 | 10 | 2.8 | COCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
18931096 | 58764 | None | 0 | Pig | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 689 | 14 | 2 | 12 | 4.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(OCCO)nc1OCCOc1ncc(Br)cn1 | 10.1016/s0960-894x(01)00682-5 | |||
CHEMBL168604 | 58764 | None | 0 | Pig | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 689 | 14 | 2 | 12 | 4.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(OCCO)nc1OCCOc1ncc(Br)cn1 | 10.1016/s0960-894x(01)00682-5 | |||
44284481 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | |||||
CHEMBL437472 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | |||||
10722371 | 102283 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 605 | 11 | 1 | 11 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN3CCOCC3)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL302974 | 102283 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 605 | 11 | 1 | 11 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN3CCOCC3)c2)cc1 | 10.1021/jm980504w | |||
10578853 | 103647 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 564 | 10 | 1 | 11 | 3.4 | COC(=O)COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | |||
CHEMBL308646 | 103647 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 564 | 10 | 1 | 11 | 3.4 | COC(=O)COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | |||
44334128 | 4407 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 443 | 7 | 1 | 5 | 4.9 | C=CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL101424 | 4407 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 443 | 7 | 1 | 5 | 4.9 | C=CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
9939238 | 206586 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 637 | 12 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL70385 | 206586 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 637 | 12 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
44284481 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(97)00400-9 | |||||
CHEMBL437472 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(97)00400-9 | |||||
CHEMBL1790960 | 211368 | None | 0 | Pig | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | None | None | None | CCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00077a013 | |||||
10120499 | 109812 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 564 | 12 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CC(C)C | 10.1021/jm970101g | |||
CHEMBL323055 | 109812 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 564 | 12 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CC(C)C | 10.1021/jm970101g | |||
11113541 | 205726 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 476 | 7 | 1 | 7 | 5.2 | COc1ccc(OC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL64632 | 205726 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 476 | 7 | 1 | 7 | 5.2 | COc1ccc(OC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
10299555 | 101087 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 481 | 6 | 2 | 7 | 4.9 | CC(=O)c1cc(C)cc(C)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL294563 | 101087 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 481 | 6 | 2 | 7 | 4.9 | CC(=O)c1cc(C)cc(C)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
10321290 | 4638 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 445 | 7 | 1 | 5 | 5.1 | CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL102969 | 4638 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 445 | 7 | 1 | 5 | 5.1 | CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
10651488 | 163474 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | |||
CHEMBL419367 | 163474 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | |||
44284381 | 128576 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 462 | 6 | 3 | 7 | 4.3 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(O)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL36671 | 128576 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 462 | 6 | 3 | 7 | 4.3 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(O)c1 | 10.1016/j.bmcl.2004.01.008 | |||
10648937 | 209765 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9334 | 209765 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
44284481 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.bmcl.2013.01.025 | |||||
CHEMBL437472 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.bmcl.2013.01.025 | |||||
123883 | 14650 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 927 | 12 | 9 | 11 | 0.8 | CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm970101g | |||
CHEMBL1205177 | 14650 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 927 | 12 | 9 | 11 | 0.8 | CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm970101g | |||
CHEMBL61425 | 14650 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 927 | 12 | 9 | 11 | 0.8 | CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm970101g | |||
123883 | 14650 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 927 | 12 | 9 | 11 | 0.8 | CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm030528p | |||
CHEMBL1205177 | 14650 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 927 | 12 | 9 | 11 | 0.8 | CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm030528p | |||
CHEMBL61425 | 14650 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 927 | 12 | 9 | 11 | 0.8 | CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm030528p | |||
11006532 | 12247 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 601 | 10 | 1 | 9 | 6.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL1184515 | 12247 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 601 | 10 | 1 | 9 | 6.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL367445 | 12247 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 601 | 10 | 1 | 9 | 6.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 | 10.1021/jm0102304 | |||
9894460 | 209167 | None | 11 | Human | Binding | pIC50 | = | 9.6 | 9.6 | 24 | 3 | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm970101g | |||
CHEMBL313871 | 209167 | None | 11 | Human | Binding | pIC50 | = | 9.6 | 9.6 | 24 | 3 | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm970101g | |||
CHEMBL8978 | 209167 | None | 11 | Human | Binding | pIC50 | = | 9.6 | 9.6 | 24 | 3 | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm970101g | |||
22004774 | 100863 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 442 | 8 | 1 | 6 | 5.7 | CCCCSC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL293192 | 100863 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 442 | 8 | 1 | 6 | 5.7 | CCCCSC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL2304284 | 211947 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/np900287e | |||||
44387242 | 120467 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 502 | 15 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(C)C | 10.1021/jm031041j | |||
CHEMBL353560 | 120467 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 502 | 15 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(C)C | 10.1021/jm031041j | |||
11093237 | 10410 | None | 0 | Pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 601 | 10 | 1 | 9 | 6.4 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc3ccccc3c2)nc1 | 10.1021/jm0102304 | |||
CHEMBL116281 | 10410 | None | 0 | Pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 601 | 10 | 1 | 9 | 6.4 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc3ccccc3c2)nc1 | 10.1021/jm0102304 | |||
10769526 | 102755 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 578 | 12 | 2 | 10 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCC(=O)O)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL304762 | 102755 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 578 | 12 | 2 | 10 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCC(=O)O)c2)cc1 | 10.1021/jm980504w | |||
9870959 | 8919 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | |||
CHEMBL109778 | 8919 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | |||
44339655 | 9108 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 530 | 14 | 1 | 6 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
CHEMBL109926 | 9108 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 530 | 14 | 1 | 6 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
10278777 | 168235 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | |||
CHEMBL432974 | 168235 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | |||
9870830 | 209172 | None | 29 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 66 | 2 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | |||
CHEMBL8981 | 209172 | None | 29 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 66 | 2 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | |||
9939238 | 206586 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 637 | 12 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL70385 | 206586 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 637 | 12 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | |||
21041284 | 171040 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 568 | 13 | 2 | 9 | 3.9 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4455360 | 171040 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 568 | 13 | 2 | 9 | 3.9 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
58688006 | 171219 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 524 | 13 | 2 | 9 | 3.8 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4458005 | 171219 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 524 | 13 | 2 | 9 | 3.8 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
21041264 | 82042 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 600 | 12 | 2 | 8 | 4.0 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
CHEMBL2165339 | 82042 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 600 | 12 | 2 | 8 | 4.0 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
10311570 | 14636 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL1205068 | 14636 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL48907 | 14636 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | |||
10555424 | 206494 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 592 | 13 | 2 | 10 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCCC(=O)O)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL69832 | 206494 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 592 | 13 | 2 | 10 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCCC(=O)O)c2)cc1 | 10.1021/jm980504w | |||
9870830 | 209172 | None | 29 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 66 | 2 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL8981 | 209172 | None | 29 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 66 | 2 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm980504w | |||
9871348 | 206485 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 520 | 8 | 1 | 10 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4nsnc4c3)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL69741 | 206485 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 520 | 8 | 1 | 10 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4nsnc4c3)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/s0960-894x(97)10151-2 | |||
9809919 | 206867 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 2 | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL72037 | 206867 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 2 | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
44284481 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(97)00400-9 | |||||
CHEMBL437472 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(97)00400-9 | |||||
159594 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm031041j | |||
159594.0 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm031041j | |||
3487 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm031041j | |||
CHEMBL9194 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm031041j | |||
DB06199 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm031041j | |||
159594 | 522 | None | 36 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm030528p | |||
159594.0 | 522 | None | 36 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm030528p | |||
3487 | 522 | None | 36 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm030528p | |||
CHEMBL9194 | 522 | None | 36 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm030528p | |||
DB06199 | 522 | None | 36 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm030528p | |||
159594 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm9505369 | |||
159594.0 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm9505369 | |||
3487 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm9505369 | |||
CHEMBL9194 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm9505369 | |||
DB06199 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm9505369 | |||
11144344 | 205470 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 424 | 8 | 1 | 5 | 5.8 | CCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL63267 | 205470 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 424 | 8 | 1 | 5 | 5.8 | CCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
44334150 | 4536 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 445 | 6 | 1 | 5 | 5.0 | COc1ccc([C@@H]2c3nc(CC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL102314 | 4536 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 445 | 6 | 1 | 5 | 5.0 | COc1ccc([C@@H]2c3nc(CC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
9852318 | 9616 | None | 8 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | |||
CHEMBL112624 | 9616 | None | 8 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | |||
CHEMBL1627022 | 9616 | None | 8 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | |||
11102201 | 205681 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 438 | 9 | 1 | 6 | 5.1 | C=CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL64447 | 205681 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 438 | 9 | 1 | 6 | 5.1 | C=CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
44266903 | 14592 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 536 | 11 | 1 | 9 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
CHEMBL10862 | 14592 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 536 | 11 | 1 | 9 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
CHEMBL1204672 | 14592 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 536 | 11 | 1 | 9 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
9960931 | 108077 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 635 | 12 | 1 | 12 | 4.1 | CCOC(=O)CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | |||
CHEMBL319452 | 108077 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 635 | 12 | 1 | 12 | 4.1 | CCOC(=O)CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | |||
159594 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | |||
159594.0 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | |||
3487 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | |||
CHEMBL9194 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | |||
DB06199 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | |||
9914310 | 209101 | None | 9 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 2 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL8923 | 209101 | None | 9 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 2 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
9870830 | 209172 | None | 29 | Human | Binding | pIC50 | = | 9.4 | 9.4 | 66 | 2 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/S0960-894X(97)00002-4 | |||
CHEMBL8981 | 209172 | None | 29 | Human | Binding | pIC50 | = | 9.4 | 9.4 | 66 | 2 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/S0960-894X(97)00002-4 | |||
11017436 | 9952 | None | 0 | Pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 597 | 12 | 1 | 11 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(SC)cn1 | 10.1021/jm0102304 | |||
CHEMBL114660 | 9952 | None | 0 | Pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 597 | 12 | 1 | 11 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(SC)cn1 | 10.1021/jm0102304 | |||
44333913 | 5103 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 431 | 6 | 1 | 5 | 4.8 | CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL105591 | 5103 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 431 | 6 | 1 | 5 | 4.8 | CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
9870959 | 8919 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | |||
CHEMBL109778 | 8919 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | |||
9809526 | 14865 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 614 | 12 | 2 | 11 | 3.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL1207463 | 14865 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 614 | 12 | 2 | 11 | 3.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL408055 | 14865 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 614 | 12 | 2 | 11 | 3.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 | 10.1021/jm980504w | |||
44284481 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm701575k | |||||
CHEMBL437472 | 216186 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -4 | 5 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm701575k | |||||
10208674 | 101908 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 529 | 7 | 2 | 7 | 5.6 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)c2ccccc2)c1 | 10.1021/jm030528p | |||
CHEMBL300547 | 101908 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 529 | 7 | 2 | 7 | 5.6 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)c2ccccc2)c1 | 10.1021/jm030528p | |||
10603409 | 110667 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | |||
CHEMBL325581 | 110667 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | |||
9852318 | 9616 | None | 8 | Human | Binding | pIC50 | = | 9.4 | 9.4 | 2691 | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/acs.jmedchem.5b01781 | |||
CHEMBL112624 | 9616 | None | 8 | Human | Binding | pIC50 | = | 9.4 | 9.4 | 2691 | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/acs.jmedchem.5b01781 | |||
CHEMBL1627022 | 9616 | None | 8 | Human | Binding | pIC50 | = | 9.4 | 9.4 | 2691 | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/acs.jmedchem.5b01781 | |||
44332735 | 172805 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 649 | 13 | 1 | 12 | 4.5 | CCOC(=O)CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | |||
CHEMBL450337 | 172805 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 649 | 13 | 1 | 12 | 4.5 | CCOC(=O)CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | |||
159594 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm960077r | |||
159594.0 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm960077r | |||
3487 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm960077r | |||
CHEMBL9194 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm960077r | |||
DB06199 | 522 | None | 36 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm960077r | |||
9852318 | 9616 | None | 8 | Human | Binding | pIC50 | = | 9.4 | 9.4 | 2691 | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | |||
CHEMBL112624 | 9616 | None | 8 | Human | Binding | pIC50 | = | 9.4 | 9.4 | 2691 | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | |||
CHEMBL1627022 | 9616 | None | 8 | Human | Binding | pIC50 | = | 9.4 | 9.4 | 2691 | 2 | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | |||
71462245 | 81697 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 588 | 13 | 2 | 10 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cc(OC)ccc1Cl | 10.1021/jm3009103 | |||
CHEMBL2163692 | 81697 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 588 | 13 | 2 | 10 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cc(OC)ccc1Cl | 10.1021/jm3009103 | |||
44386169 | 131457 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 690 | 12 | 2 | 14 | 3.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL368996 | 131457 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 690 | 12 | 2 | 14 | 3.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
11122784 | 163017 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 426 | 8 | 1 | 6 | 4.9 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL417413 | 163017 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 426 | 8 | 1 | 6 | 4.9 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
44339655 | 9108 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 530 | 14 | 1 | 6 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
CHEMBL109926 | 9108 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 530 | 14 | 1 | 6 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
44284196 | 100577 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 504 | 9 | 2 | 7 | 5.4 | CCCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL291247 | 100577 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 504 | 9 | 2 | 7 | 5.4 | CCCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
10364227 | 205257 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm031041j | |||
CHEMBL62264 | 205257 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm031041j | |||
10364227 | 205257 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL62264 | 205257 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
9806559 | 9152 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 515 | 13 | 1 | 6 | 3.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O | 10.1021/jm980217s | |||
CHEMBL110053 | 9152 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 515 | 13 | 1 | 6 | 3.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O | 10.1021/jm980217s | |||
11827880 | 10228 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 565 | 10 | 1 | 9 | 5.5 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | |||
CHEMBL116046 | 10228 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 565 | 10 | 1 | 9 | 5.5 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | |||
CHEMBL177979 | 10228 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 565 | 10 | 1 | 9 | 5.5 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | |||
CHEMBL1790962 | 211369 | None | 0 | Pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | |||||
10303555 | 163476 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 574 | 15 | 1 | 7 | 4.9 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | |||
CHEMBL419383 | 163476 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 574 | 15 | 1 | 7 | 4.9 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | |||
10578320 | 97363 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 538 | 12 | 1 | 6 | 5.2 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CCC(C)C)CCC(C)C)cc1 | 10.1021/jm9505369 | |||
CHEMBL269141 | 97363 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 538 | 12 | 1 | 6 | 5.2 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CCC(C)C)CCC(C)C)cc1 | 10.1021/jm9505369 | |||
10182624 | 99607 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 453 | 6 | 2 | 6 | 4.9 | CCc1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm000349x | |||
CHEMBL283582 | 99607 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 453 | 6 | 2 | 6 | 4.9 | CCc1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm000349x | |||
9870830 | 209172 | None | 29 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 2 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL8981 | 209172 | None | 29 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 2 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/s0960-894x(97)10151-2 | |||
9825494 | 205067 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL61211 | 205067 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
44380648 | 120577 | None | 0 | Pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 727 | 12 | 1 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCN(C)CC2)nc1OCCOc1ncc(Br)cn1 | 10.1016/s0960-894x(01)00682-5 | |||
CHEMBL354528 | 120577 | None | 0 | Pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 727 | 12 | 1 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCN(C)CC2)nc1OCCOc1ncc(Br)cn1 | 10.1016/s0960-894x(01)00682-5 | |||
10210629 | 8766 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL109644 | 8766 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
10167052 | 109695 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 578 | 13 | 1 | 7 | 4.5 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCC(C)C | 10.1021/jm970101g | |||
CHEMBL322297 | 109695 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 578 | 13 | 1 | 7 | 4.5 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCC(C)C | 10.1021/jm970101g | |||
44265870 | 210030 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 524 | 12 | 1 | 6 | 5.1 | CCCCN(CCCC)C(=O)C(C)N1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9488 | 210030 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 524 | 12 | 1 | 6 | 5.1 | CCCCN(CCCC)C(=O)C(C)N1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
10391487 | 9663 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | |||
CHEMBL112832 | 9663 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | |||
10983045 | 205364 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 440 | 9 | 1 | 6 | 5.3 | CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL62762 | 205364 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 440 | 9 | 1 | 6 | 5.3 | CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
11050177 | 10261 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 585 | 10 | 1 | 9 | 6.1 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL116108 | 10261 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 585 | 10 | 1 | 9 | 6.1 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL175501 | 10261 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 585 | 10 | 1 | 9 | 6.1 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 | 10.1021/jm0102304 | |||
9915028 | 9413 | None | 19 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 21877 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL4507258 | |||
CHEMBL111612 | 9413 | None | 19 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 21877 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL4507258 | |||
CHEMBL4761843 | 9413 | None | 19 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 21877 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL4507258 | |||
9915028 | 9413 | None | 19 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 21877 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm010237l | |||
CHEMBL111612 | 9413 | None | 19 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 21877 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm010237l | |||
CHEMBL4761843 | 9413 | None | 19 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 21877 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm010237l | |||
10391487 | 9663 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm031041j | |||
CHEMBL112832 | 9663 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm031041j | |||
10840068 | 60377 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 536 | 11 | 1 | 9 | 4.4 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm031041j | |||
CHEMBL174573 | 60377 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 536 | 11 | 1 | 9 | 4.4 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm031041j | |||
44387124 | 130959 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 524 | 13 | 1 | 6 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](CC(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm031041j | |||
CHEMBL368558 | 130959 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 524 | 13 | 1 | 6 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](CC(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm031041j | |||
10530409 | 5708 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 536 | 9 | 1 | 10 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | |||
CHEMBL10781 | 5708 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 536 | 9 | 1 | 10 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | |||
10815823 | 9799 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 520 | 8 | 1 | 9 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C | 10.1021/jm9606507 | |||
CHEMBL11369 | 9799 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 520 | 8 | 1 | 9 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C | 10.1021/jm9606507 | |||
15411009 | 107246 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 691 | 14 | 1 | 12 | 5.6 | CCOC(=O)C(CC(C)C)NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | |||
CHEMBL316523 | 107246 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 691 | 14 | 1 | 12 | 5.6 | CCOC(=O)C(CC(C)C)NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | |||
10391487 | 9663 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL112832 | 9663 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
16004692 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | |||
16004692.0 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | |||
4809 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | |||
7352 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL2103873 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | |||
DB08932 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | |||
157574 | 78421 | None | 8 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 517 | 4 | 1 | 5 | 5.0 | CCc1cc(C2=C(C(=O)O)N(c3ccccc3C(F)(F)F)S(=O)(=O)c3ccccc32)cc2c1OCO2 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL2110610 | 78421 | None | 8 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 517 | 4 | 1 | 5 | 5.0 | CCc1cc(C2=C(C(=O)O)N(c3ccccc3C(F)(F)F)S(=O)(=O)c3ccccc32)cc2c1OCO2 | 10.1016/j.bmcl.2016.06.014 | |||
21041283 | 173250 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 552 | 13 | 2 | 9 | 3.2 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4521348 | 173250 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 552 | 13 | 2 | 9 | 3.2 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
155544917 | 173518 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 540 | 13 | 2 | 10 | 3.4 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4528516 | 173518 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 540 | 13 | 2 | 10 | 3.4 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 | 10.1016/j.bmcl.2016.06.014 | |||
16004692 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | |||
16004692.0 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | |||
4809 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | |||
7352 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | |||
CHEMBL2103873 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | |||
DB08932 | 2454 | None | 59 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | |||
44279554 | 99380 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 512 | 11 | 2 | 7 | 3.8 | COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
CHEMBL282187 | 99380 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 512 | 11 | 2 | 7 | 3.8 | COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
11754394 | 108684 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 468 | 8 | 2 | 6 | 3.8 | CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
CHEMBL32066 | 108684 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 468 | 8 | 2 | 6 | 3.8 | CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
9933950 | 205284 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL62395 | 205284 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
10553384 | 109724 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 498 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 | 10.1021/jm980217s | |||
CHEMBL322537 | 109724 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 498 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 | 10.1021/jm980217s | |||
44333721 | 167896 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 447 | 7 | 1 | 6 | 4.3 | CCOCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL430506 | 167896 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 447 | 7 | 1 | 6 | 4.3 | CCOCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
9916235 | 9355 | None | 1 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL111277 | 9355 | None | 1 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
10994374 | 205874 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 474 | 7 | 1 | 6 | 5.4 | COc1ccc(CC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL65619 | 205874 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 474 | 7 | 1 | 6 | 5.4 | COc1ccc(CC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
10651146 | 108920 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 596 | 12 | 1 | 8 | 4.4 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(OC)cc1 | 10.1021/jm970101g | |||
CHEMBL321035 | 108920 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 596 | 12 | 1 | 8 | 4.4 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(OC)cc1 | 10.1021/jm970101g | |||
10982740 | 205841 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 422 | 5 | 1 | 5 | 5.4 | CC(C)Oc1ccc2c(c1)C(C1CCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
CHEMBL65353 | 205841 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 422 | 5 | 1 | 5 | 5.4 | CC(C)Oc1ccc2c(c1)C(C1CCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
10187997 | 110028 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL323464 | 110028 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | |||
10651488 | 163474 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | |||
CHEMBL419367 | 163474 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | |||
9915510 | 85189 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 549 | 8 | 2 | 8 | 3.4 | CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | |||
CHEMBL22513 | 85189 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 549 | 8 | 2 | 8 | 3.4 | CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | |||
9915510 | 85189 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 549 | 8 | 2 | 8 | 3.4 | CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1007/s00044-004-0021-y | |||
CHEMBL22513 | 85189 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 549 | 8 | 2 | 8 | 3.4 | CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1007/s00044-004-0021-y | |||
44334097 | 110125 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 447 | 7 | 2 | 6 | 3.7 | COc1ccc([C@@H]2c3nc(CCCO)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL323561 | 110125 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 447 | 7 | 2 | 6 | 3.7 | COc1ccc([C@@H]2c3nc(CCCO)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
10719598 | 209448 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9139 | 209448 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
9915028 | 9413 | None | 19 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | |||
CHEMBL111612 | 9413 | None | 19 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | |||
CHEMBL4761843 | 9413 | None | 19 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | |||
10886132 | 9811 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 549 | 10 | 1 | 9 | 4.8 | COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | |||
CHEMBL113757 | 9811 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 549 | 10 | 1 | 9 | 4.8 | COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | |||
CHEMBL368796 | 9811 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 549 | 10 | 1 | 9 | 4.8 | COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | |||
10744973 | 209734 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 538 | 14 | 1 | 6 | 5.5 | CCCCCN(CCCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9313 | 209734 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 538 | 14 | 1 | 6 | 5.5 | CCCCCN(CCCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
10209779 | 163526 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 560 | 14 | 1 | 7 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | |||
CHEMBL419749 | 163526 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 560 | 14 | 1 | 7 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | |||
11015826 | 205989 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 450 | 6 | 1 | 5 | 6.1 | CC(C)Oc1ccc2c(c1)C(CC1CCCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
CHEMBL66426 | 205989 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 450 | 6 | 1 | 5 | 6.1 | CC(C)Oc1ccc2c(c1)C(CC1CCCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
9915028 | 9413 | None | 19 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 21877 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL5210121 | |||
CHEMBL111612 | 9413 | None | 19 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 21877 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL5210121 | |||
CHEMBL4761843 | 9413 | None | 19 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 21877 | 3 | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL5210121 | |||
10346184 | 9198 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | |||
CHEMBL110366 | 9198 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | |||
15411005 | 4762 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 677 | 13 | 1 | 12 | 5.2 | CCOC(=O)C(NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1)C(C)C | 10.1016/S0960-894X(97)00002-4 | |||
CHEMBL103846 | 4762 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 677 | 13 | 1 | 12 | 5.2 | CCOC(=O)C(NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1)C(C)C | 10.1016/S0960-894X(97)00002-4 | |||
10346184 | 9198 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL110366 | 9198 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL2373291 | 212833 | None | 0 | Pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | |||||
10579303 | 9433 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 590 | 16 | 1 | 8 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCOC)cc1 | 10.1021/jm970101g | |||
CHEMBL111712 | 9433 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 590 | 16 | 1 | 8 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCOC)cc1 | 10.1021/jm970101g | |||
11015645 | 205645 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 438 | 9 | 1 | 5 | 6.1 | CCCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL64282 | 205645 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 438 | 9 | 1 | 5 | 6.1 | CCCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
10938122 | 163101 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 396 | 5 | 1 | 5 | 4.8 | CC(C)Oc1ccc2c(c1)C(C(C)C)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
CHEMBL417555 | 163101 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 396 | 5 | 1 | 5 | 4.8 | CC(C)Oc1ccc2c(c1)C(C(C)C)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
10503921 | 101531 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1noc(C)c1Cl)OCO2 | 10.1021/jm9700068 | |||
CHEMBL297783 | 101531 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1noc(C)c1Cl)OCO2 | 10.1021/jm9700068 | |||
44279141 | 107079 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 498 | 10 | 3 | 7 | 3.2 | COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)NCCO)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
CHEMBL31544 | 107079 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 498 | 10 | 3 | 7 | 3.2 | COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)NCCO)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
10552883 | 110060 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 484 | 13 | 1 | 5 | 4.8 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C1CC1 | 10.1021/jm980217s | |||
CHEMBL323485 | 110060 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 484 | 13 | 1 | 5 | 4.8 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C1CC1 | 10.1021/jm980217s | |||
10974047 | 9519 | None | 0 | Pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 601 | 11 | 1 | 10 | 4.3 | COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1OC | 10.1021/jm0102304 | |||
CHEMBL112162 | 9519 | None | 0 | Pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 601 | 11 | 1 | 10 | 4.3 | COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1OC | 10.1021/jm0102304 | |||
10745942 | 9313 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 588 | 13 | 1 | 8 | 4.3 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc2c(c1)OCCO2 | 10.1021/jm970101g | |||
CHEMBL111010 | 9313 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 588 | 13 | 1 | 8 | 4.3 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc2c(c1)OCCO2 | 10.1021/jm970101g | |||
11080933 | 205870 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 454 | 10 | 1 | 6 | 5.7 | CCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL65599 | 205870 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 454 | 10 | 1 | 6 | 5.7 | CCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
10166223 | 205168 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 552 | 7 | 2 | 7 | 5.5 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)CC(C)(C)C)c1 | 10.1021/jm030528p | |||
CHEMBL61711 | 205168 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 552 | 7 | 2 | 7 | 5.5 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)CC(C)(C)C)c1 | 10.1021/jm030528p | |||
10076527 | 14621 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 485 | 7 | 2 | 6 | 4.3 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3ccccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | |||
CHEMBL1204990 | 14621 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 485 | 7 | 2 | 6 | 4.3 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3ccccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | |||
10720982 | 127884 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 530 | 9 | 2 | 6 | 4.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 | 10.1021/jm031041j | |||
CHEMBL121647 | 127884 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 530 | 9 | 2 | 6 | 4.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 | 10.1021/jm031041j | |||
CHEMBL366441 | 127884 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 530 | 9 | 2 | 6 | 4.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 | 10.1021/jm031041j | |||
71462320 | 82035 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 570 | 11 | 2 | 8 | 3.9 | Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL2165332 | 82035 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 570 | 11 | 2 | 8 | 3.9 | Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
10720982 | 127884 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 530 | 9 | 2 | 6 | 4.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 | 10.1021/jm990171i | |||
CHEMBL121647 | 127884 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 530 | 9 | 2 | 6 | 4.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 | 10.1021/jm990171i | |||
CHEMBL366441 | 127884 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 530 | 9 | 2 | 6 | 4.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 | 10.1021/jm990171i | |||
10649266 | 9634 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL112685 | 9634 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
11505449 | 171587 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 616 | 12 | 3 | 9 | 2.6 | O=C(O)CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4463633 | 171587 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 616 | 12 | 3 | 9 | 2.6 | O=C(O)CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
58688005 | 175064 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 540 | 11 | 2 | 9 | 3.1 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4565926 | 175064 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 540 | 11 | 2 | 9 | 3.1 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
71462320 | 82035 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 570 | 11 | 2 | 8 | 3.9 | Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | |||
CHEMBL2165332 | 82035 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 570 | 11 | 2 | 8 | 3.9 | Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | |||
10746431 | 102361 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 619 | 12 | 1 | 11 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCOCC3)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL303484 | 102361 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 619 | 12 | 1 | 11 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCOCC3)c2)cc1 | 10.1021/jm980504w | |||
9809919 | 206867 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 2 | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL72037 | 206867 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 2 | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL2373292 | 212834 | None | 0 | Pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | |||||
9870959 | 8919 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | |||
CHEMBL109778 | 8919 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | |||
10916597 | 205773 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL64832 | 205773 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
44284184 | 140087 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 490 | 8 | 2 | 7 | 5.0 | CCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL38000 | 140087 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 490 | 8 | 2 | 7 | 5.0 | CCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL427748 | 215833 | None | 0 | Pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | |||||
11827489 | 117050 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 12 | 1 | 4 | 5.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 | 10.1021/jm010237l | |||
CHEMBL338754 | 117050 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 12 | 1 | 4 | 5.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 | 10.1021/jm010237l | |||
10984671 | 9475 | None | 0 | Pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 571 | 10 | 1 | 9 | 4.3 | COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1 | 10.1021/jm0102304 | |||
CHEMBL111934 | 9475 | None | 0 | Pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 571 | 10 | 1 | 9 | 4.3 | COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1 | 10.1021/jm0102304 | |||
10648006 | 161760 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 468 | 6 | 1 | 6 | 4.7 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1021/jm9700068 | |||
CHEMBL413093 | 161760 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 468 | 6 | 1 | 6 | 4.7 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1021/jm9700068 | |||
10648135 | 9344 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 472 | 13 | 1 | 5 | 4.7 | C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm031041j | |||
CHEMBL111218 | 9344 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 472 | 13 | 1 | 5 | 4.7 | C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm031041j | |||
10209320 | 9287 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 546 | 12 | 1 | 7 | 4.0 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC(C)C | 10.1021/jm970101g | |||
CHEMBL110899 | 9287 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 546 | 12 | 1 | 7 | 4.0 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC(C)C | 10.1021/jm970101g | |||
11038320 | 18880 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 492 | 11 | 1 | 4 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 | 10.1021/jm010237l | |||
CHEMBL128240 | 18880 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 492 | 11 | 1 | 4 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 | 10.1021/jm010237l | |||
44340049 | 110387 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 500 | 13 | 1 | 5 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
CHEMBL323951 | 110387 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 500 | 13 | 1 | 5 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
10552413 | 110731 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 472 | 13 | 1 | 5 | 4.7 | C/C=C\CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
CHEMBL325935 | 110731 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 472 | 13 | 1 | 5 | 4.7 | C/C=C\CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
44266851 | 14591 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 550 | 11 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C | 10.1021/jm9606507 | |||
CHEMBL10847 | 14591 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 550 | 11 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C | 10.1021/jm9606507 | |||
CHEMBL1204671 | 14591 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 550 | 11 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C | 10.1021/jm9606507 | |||
44279316 | 107402 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 518 | 8 | 2 | 6 | 4.0 | COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
CHEMBL31763 | 107402 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 518 | 8 | 2 | 6 | 4.0 | COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
137649592 | 157502 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 567 | 10 | 2 | 9 | 4.6 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
CHEMBL4078537 | 157502 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 567 | 10 | 2 | 9 | 4.6 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
15411003 | 108776 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 589 | 11 | 1 | 10 | 4.8 | C=CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | |||
CHEMBL320839 | 108776 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 589 | 11 | 1 | 10 | 4.8 | C=CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | |||
10673644 | 9784 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL113611 | 9784 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
177236 | 1325 | None | 32 | Human | Binding | pIC50 | = | 9.1 | 9.1 | 2 | 3 | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(01)00660-6 | |||
3508 | 1325 | None | 32 | Human | Binding | pIC50 | = | 9.1 | 9.1 | 2 | 3 | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(01)00660-6 | |||
CHEMBL23261 | 1325 | None | 32 | Human | Binding | pIC50 | = | 9.1 | 9.1 | 2 | 3 | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(01)00660-6 | |||
DB04883 | 1325 | None | 32 | Human | Binding | pIC50 | = | 9.1 | 9.1 | 2 | 3 | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(01)00660-6 | |||
71462322 | 82041 | None | 12 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 572 | 10 | 2 | 8 | 3.2 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
CHEMBL2165338 | 82041 | None | 12 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 572 | 10 | 2 | 8 | 3.2 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
44284199 | 100164 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 552 | 9 | 2 | 7 | 6.2 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL287517 | 100164 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 552 | 9 | 2 | 7 | 6.2 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.01.008 | |||
10993320 | 205438 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 412 | 6 | 1 | 6 | 4.6 | CC(C)OC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL63067 | 205438 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 412 | 6 | 1 | 6 | 4.6 | CC(C)OC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
10097589 | 208739 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 502 | 7 | 2 | 7 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCC(C(=O)O)CC1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL86965 | 208739 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 502 | 7 | 2 | 7 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCC(C(=O)O)CC1 | 10.1016/s0960-894x(00)00513-8 | |||
10792319 | 209692 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 530 | 10 | 1 | 6 | 5.1 | CCCCN(C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm9505369 | |||
CHEMBL9283 | 209692 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 530 | 10 | 1 | 6 | 5.1 | CCCCN(C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm9505369 | |||
10648937 | 209765 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9334 | 209765 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
10673644 | 9784 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | |||
CHEMBL113611 | 9784 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | |||
10814655 | 210059 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9502 | 210059 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
44339714 | 111371 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 500 | 14 | 1 | 5 | 5.4 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC/C=C(/C)CC | 10.1021/jm980217s | |||
CHEMBL326685 | 111371 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 500 | 14 | 1 | 5 | 5.4 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC/C=C(/C)CC | 10.1021/jm980217s | |||
10984617 | 10010 | None | 0 | Pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 565 | 11 | 1 | 10 | 4.9 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(C)cn2)c1 | 10.1021/jm0102304 | |||
CHEMBL114933 | 10010 | None | 0 | Pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 565 | 11 | 1 | 10 | 4.9 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(C)cn2)c1 | 10.1021/jm0102304 | |||
44284183 | 139662 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 518 | 9 | 2 | 7 | 5.7 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCC(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | |||
CHEMBL37973 | 139662 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 518 | 9 | 2 | 7 | 5.7 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCC(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | |||
11027946 | 18920 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 540 | 12 | 1 | 5 | 5.4 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 | 10.1021/jm010237l | |||
CHEMBL128479 | 18920 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 540 | 12 | 1 | 5 | 5.4 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 | 10.1021/jm010237l | |||
11006213 | 169372 | None | 0 | Pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 557 | 10 | 1 | 10 | 5.3 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cccs2)nc1 | 10.1021/jm0102304 | |||
CHEMBL441277 | 169372 | None | 0 | Pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 557 | 10 | 1 | 10 | 5.3 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cccs2)nc1 | 10.1021/jm0102304 | |||
10602743 | 7159 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 550 | 9 | 1 | 10 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C | 10.1021/jm9606507 | |||
CHEMBL10854 | 7159 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 550 | 9 | 1 | 10 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C | 10.1021/jm9606507 | |||
10983992 | 19468 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 | 10.1021/jm010237l | |||
CHEMBL129740 | 19468 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 | 10.1021/jm010237l | |||
44333598 | 109246 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 447 | 7 | 1 | 6 | 4.6 | CCCOc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL321520 | 109246 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 447 | 7 | 1 | 6 | 4.6 | CCCOc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
11037806 | 205282 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 456 | 10 | 2 | 7 | 4.3 | CC(C)Oc1ccc2c(c1)C(OCCCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
CHEMBL62376 | 205282 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 456 | 10 | 2 | 7 | 4.3 | CC(C)Oc1ccc2c(c1)C(OCCCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
10788494 | 170726 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 424 | 6 | 1 | 6 | 4.5 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9700068 | |||
CHEMBL445101 | 170726 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 424 | 6 | 1 | 6 | 4.5 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9700068 | |||
10768294 | 14594 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 520 | 10 | 1 | 8 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C | 10.1021/jm9606507 | |||
CHEMBL10922 | 14594 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 520 | 10 | 1 | 8 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C | 10.1021/jm9606507 | |||
CHEMBL1204674 | 14594 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 520 | 10 | 1 | 8 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C | 10.1021/jm9606507 | |||
10625694 | 11450 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 516 | 9 | 2 | 6 | 4.5 | CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | |||
CHEMBL1180344 | 11450 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 516 | 9 | 2 | 6 | 4.5 | CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | |||
CHEMBL123107 | 11450 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 516 | 9 | 2 | 6 | 4.5 | CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | |||
9868379 | 100837 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 450 | 5 | 1 | 6 | 5.6 | Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 | 10.1021/jm010382z | |||
CHEMBL293012 | 100837 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 450 | 5 | 1 | 6 | 5.6 | Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 | 10.1021/jm010382z | |||
44332842 | 109777 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 703 | 11 | 1 | 10 | 7.5 | COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/S0960-894X(97)00002-4 | |||
CHEMBL322920 | 109777 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 703 | 11 | 1 | 10 | 7.5 | COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/S0960-894X(97)00002-4 | |||
44314904 | 103202 | None | 0 | Pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 585 | 12 | 5 | 5 | 3.6 | CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL307936 | 103202 | None | 0 | Pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 585 | 12 | 5 | 5 | 3.6 | CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | |||
10649321 | 111009 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL326191 | 111009 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
3951 | 391 | None | 55 | Human | Binding | pIC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | |||
4337 | 391 | None | 55 | Human | Binding | pIC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | |||
6918493 | 391 | None | 55 | Human | Binding | pIC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | |||
6918493.0 | 391 | None | 55 | Human | Binding | pIC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL1111 | 391 | None | 55 | Human | Binding | pIC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | |||
DB06403 | 391 | None | 55 | Human | Binding | pIC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | |||
9868379 | 100837 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 450 | 5 | 1 | 6 | 5.6 | Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL293012 | 100837 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 450 | 5 | 1 | 6 | 5.6 | Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 | 10.1016/j.bmcl.2016.06.014 | |||
155519384 | 170521 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 674 | 12 | 1 | 13 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4448273 | 170521 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 674 | 12 | 1 | 13 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 | 10.1016/j.bmcl.2016.06.014 | |||
155551580 | 174097 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 526 | 12 | 2 | 10 | 3.0 | CCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4542394 | 174097 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 526 | 12 | 2 | 10 | 3.0 | CCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 | 10.1016/j.bmcl.2016.06.014 | |||
10146305 | 174375 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 656 | 14 | 2 | 13 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2cccs2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4549357 | 174375 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 656 | 14 | 2 | 13 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2cccs2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | |||
44439102 | 90333 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 508 | 8 | 1 | 7 | 5.2 | CN(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1ccno1)C(=O)CC(C)(C)C | 10.1016/j.bmcl.2006.10.009 | |||
CHEMBL238539 | 90333 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 508 | 8 | 1 | 7 | 5.2 | CN(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1ccno1)C(=O)CC(C)(C)C | 10.1016/j.bmcl.2006.10.009 | |||
71460621 | 82032 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 602 | 13 | 2 | 10 | 3.7 | COc1cccc(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1021/jm3009103 | |||
CHEMBL2165329 | 82032 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 602 | 13 | 2 | 10 | 3.7 | COc1cccc(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1021/jm3009103 | |||
44295173 | 14639 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 554 | 10 | 1 | 9 | 5.3 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL1205090 | 14639 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 554 | 10 | 1 | 9 | 5.3 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL51234 | 14639 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 554 | 10 | 1 | 9 | 5.3 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl | 10.1016/s0960-894x(98)00301-1 | |||
44279398 | 99943 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 454 | 8 | 2 | 6 | 3.6 | COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
CHEMBL285976 | 99943 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 454 | 8 | 2 | 6 | 3.6 | COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
44279294 | 99950 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 546 | 8 | 1 | 6 | 4.6 | COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
CHEMBL286014 | 99950 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 546 | 8 | 1 | 6 | 4.6 | COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
10897248 | 9511 | None | 0 | Pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 591 | 9 | 1 | 8 | 5.4 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc4ccccc4c3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL112134 | 9511 | None | 0 | Pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 591 | 9 | 1 | 8 | 5.4 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc4ccccc4c3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
11136124 | 10373 | None | 0 | Pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 667 | 9 | 1 | 8 | 4.9 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(I)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL116220 | 10373 | None | 0 | Pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 667 | 9 | 1 | 8 | 4.9 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(I)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
10211781 | 129809 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL367453 | 129809 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | |||
10146640 | 210013 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 689 | 12 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL94786 | 210013 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 689 | 12 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | |||
10555191 | 206250 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 577 | 12 | 1 | 10 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN(C)C)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL68269 | 206250 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 577 | 12 | 1 | 10 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN(C)C)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL1790519 | 211352 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N(C)[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC | 10.1021/jm970161m | |||||
44311346 | 103218 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 681 | 13 | 2 | 13 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL308088 | 103218 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 681 | 13 | 2 | 13 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
44340049 | 110387 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 500 | 13 | 1 | 5 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
CHEMBL323951 | 110387 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 500 | 13 | 1 | 5 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
44339662 | 9854 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 527 | 13 | 1 | 7 | 4.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1nc(C)c(C)o1 | 10.1021/jm980217s | |||
CHEMBL114074 | 9854 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 527 | 13 | 1 | 7 | 4.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1nc(C)c(C)o1 | 10.1021/jm980217s | |||
44351961 | 18843 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 522 | 13 | 1 | 5 | 5.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCC)cc1 | 10.1021/jm010237l | |||
CHEMBL128061 | 18843 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 522 | 13 | 1 | 5 | 5.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCC)cc1 | 10.1021/jm010237l | |||
10553384 | 109724 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 498 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 | 10.1021/jm980217s | |||
CHEMBL322537 | 109724 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 498 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 | 10.1021/jm980217s | |||
9909467 | 207969 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 409 | 4 | 1 | 5 | 3.8 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL80782 | 207969 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 409 | 4 | 1 | 5 | 3.8 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Br | 10.1016/0960-894X(96)00441-6 | |||
9827093 | 173528 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 494 | 9 | 2 | 7 | 5.1 | CCCc1nc(SC2CCC(CC(=O)O)CC2)c(C(=O)O)n1Cc1cc2c(cc1Cl)OCO2 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4528664 | 173528 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 494 | 9 | 2 | 7 | 5.1 | CCCc1nc(SC2CCC(CC(=O)O)CC2)c(C(=O)O)n1Cc1cc2c(cc1Cl)OCO2 | 10.1016/j.bmcl.2016.06.014 | |||
10347080 | 85261 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 535 | 7 | 2 | 8 | 3.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | |||
CHEMBL22562 | 85261 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 535 | 7 | 2 | 8 | 3.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | |||
10347080 | 85261 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 535 | 7 | 2 | 8 | 3.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1007/s00044-004-0021-y | |||
CHEMBL22562 | 85261 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 535 | 7 | 2 | 8 | 3.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1007/s00044-004-0021-y | |||
71449713 | 81699 | None | 25 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 585 | 11 | 1 | 8 | 4.5 | CCCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
CHEMBL2163694 | 81699 | None | 25 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 585 | 11 | 1 | 8 | 4.5 | CCCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
71458719 | 81709 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 647 | 15 | 1 | 13 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(SC)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163704 | 81709 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 647 | 15 | 1 | 13 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(SC)cn1 | 10.1021/jm3009103 | |||
17885918 | 106029 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 458 | 6 | 1 | 6 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccsc2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL313044 | 106029 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 458 | 6 | 1 | 6 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccsc2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | |||
9846994 | 106045 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 458 | 6 | 1 | 6 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL313153 | 106045 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 458 | 6 | 1 | 6 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | |||
44380976 | 165721 | None | 0 | Pig | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 639 | 10 | 1 | 8 | 6.7 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(C(C)C)nc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/s0960-894x(01)00682-5 | |||
CHEMBL424358 | 165721 | None | 0 | Pig | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 639 | 10 | 1 | 8 | 6.7 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(C(C)C)nc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/s0960-894x(01)00682-5 | |||
10505755 | 14590 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 506 | 10 | 1 | 8 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
CHEMBL10832 | 14590 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 506 | 10 | 1 | 8 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
CHEMBL1204670 | 14590 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 506 | 10 | 1 | 8 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
9870830 | 209172 | None | 29 | Human | Binding | pIC50 | = | 9.0 | 9.0 | 66 | 2 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | |||
CHEMBL8981 | 209172 | None | 29 | Human | Binding | pIC50 | = | 9.0 | 9.0 | 66 | 2 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | |||
10142669 | 9446 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 518 | 11 | 1 | 7 | 3.3 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC | 10.1021/jm970101g | |||
CHEMBL111769 | 9446 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 518 | 11 | 1 | 7 | 3.3 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC | 10.1021/jm970101g | |||
137637038 | 156031 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 581 | 11 | 2 | 9 | 5.0 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
CHEMBL4061110 | 156031 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 581 | 11 | 2 | 9 | 5.0 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
10649321 | 111009 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | |||
CHEMBL326191 | 111009 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | |||
10576427 | 5372 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 473 | 6 | 2 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(NC(C)=O)cc2)cc1 | 10.1021/jm9606507 | |||
CHEMBL10697 | 5372 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 473 | 6 | 2 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(NC(C)=O)cc2)cc1 | 10.1021/jm9606507 | |||
21041324 | 81695 | None | 5 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 542 | 11 | 2 | 8 | 3.5 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 | 10.1021/jm3009103 | |||
CHEMBL2163690 | 81695 | None | 5 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 542 | 11 | 2 | 8 | 3.5 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 | 10.1021/jm3009103 | |||
11093167 | 10055 | None | 0 | Pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 593 | 11 | 1 | 9 | 6.3 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C(C)C)cc2)nc1 | 10.1021/jm0102304 | |||
CHEMBL115230 | 10055 | None | 0 | Pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 593 | 11 | 1 | 9 | 6.3 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C(C)C)cc2)nc1 | 10.1021/jm0102304 | |||
11813644 | 110433 | None | 0 | Pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 551 | 11 | 1 | 10 | 4.6 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccncn2)c1 | 10.1021/jm0102304 | |||
CHEMBL324246 | 110433 | None | 0 | Pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 551 | 11 | 1 | 10 | 4.6 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccncn2)c1 | 10.1021/jm0102304 | |||
CHEMBL414165 | 215575 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](c2cccs2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
10719598 | 209448 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9139 | 209448 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
44279296 | 110693 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 532 | 8 | 2 | 6 | 4.3 | CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
CHEMBL32572 | 110693 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 532 | 8 | 2 | 6 | 4.3 | CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
10206812 | 202091 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 492 | 6 | 2 | 8 | 5.0 | Cc1cc(-c2ncco2)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL59288 | 202091 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 492 | 6 | 2 | 8 | 5.0 | Cc1cc(-c2ncco2)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
11102609 | 168673 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 462 | 6 | 1 | 6 | 5.2 | COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1021/jm031041j | |||
CHEMBL435773 | 168673 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 462 | 6 | 1 | 6 | 5.2 | COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1021/jm031041j | |||
10603546 | 110510 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCC)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL324639 | 110510 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCC)c(F)c1 | 10.1021/jm970101g | |||
11102609 | 168673 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 462 | 6 | 1 | 6 | 5.2 | COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1021/jm010382z | |||
CHEMBL435773 | 168673 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 462 | 6 | 1 | 6 | 5.2 | COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1021/jm010382z | |||
10576910 | 108595 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 486 | 13 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C(C)C | 10.1021/jm980217s | |||
CHEMBL320124 | 108595 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 486 | 13 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C(C)C | 10.1021/jm980217s | |||
10278777 | 168235 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | |||
CHEMBL432974 | 168235 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | |||
10767586 | 9771 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 496 | 13 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL113529 | 9771 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 496 | 13 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
58688008 | 175406 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 496 | 11 | 2 | 9 | 3.0 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4573273 | 175406 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 496 | 11 | 2 | 9 | 3.0 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
23670447 | 3029 | None | 2 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 2 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(98)00301-1 | |||
999 | 3029 | None | 2 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 2 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL1204799 | 3029 | None | 2 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 2 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL25438 | 3029 | None | 2 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 2 | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(98)00301-1 | |||
44320480 | 106014 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 442 | 6 | 1 | 6 | 5.4 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccco2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL312979 | 106014 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 442 | 6 | 1 | 6 | 5.4 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccco2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | |||
17885920 | 208899 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 502 | 7 | 2 | 7 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCC(C(=O)O)C1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL88011 | 208899 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 502 | 7 | 2 | 7 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCC(C(=O)O)C1 | 10.1016/s0960-894x(00)00513-8 | |||
44291775 | 101221 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 506 | 6 | 1 | 10 | 4.1 | CC#N.Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2cc3c(cc2C#N)OCO3)c1Cl | 10.1021/jm9700068 | |||
CHEMBL295557 | 101221 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 506 | 6 | 1 | 10 | 4.1 | CC#N.Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2cc3c(cc2C#N)OCO3)c1Cl | 10.1021/jm9700068 | |||
10280278 | 100897 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 535 | 7 | 2 | 7 | 6.1 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CCCCC2)c1 | 10.1021/jm030528p | |||
CHEMBL293421 | 100897 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 535 | 7 | 2 | 7 | 6.1 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CCCCC2)c1 | 10.1021/jm030528p | |||
11071347 | 117870 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 516 | 11 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 | 10.1021/jm010237l | |||
CHEMBL340190 | 117870 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 516 | 11 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 | 10.1021/jm010237l | |||
10745564 | 6227 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 566 | 11 | 1 | 7 | 4.4 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccccc1 | 10.1021/jm970101g | |||
CHEMBL108142 | 6227 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 566 | 11 | 1 | 7 | 4.4 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccccc1 | 10.1021/jm970101g | |||
11125029 | 10041 | None | 0 | Pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 627 | 11 | 2 | 9 | 4.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C(=O)O)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | |||
CHEMBL115147 | 10041 | None | 0 | Pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 627 | 11 | 2 | 9 | 4.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C(=O)O)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | |||
15453177 | 207979 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL80857 | 207979 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br | 10.1016/0960-894X(96)00441-6 | |||
10790757 | 97266 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | |||
CHEMBL268480 | 97266 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | |||
10554273 | 9412 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 532 | 13 | 1 | 7 | 4.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C1OCCO1 | 10.1021/jm980217s | |||
CHEMBL111611 | 9412 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 532 | 13 | 1 | 7 | 4.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C1OCCO1 | 10.1021/jm980217s | |||
8260 | 531 | None | 42 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | 10.1016/j.bmcl.2016.06.014 | |||
9912992 | 531 | None | 42 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL3989834 | 531 | None | 42 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | 10.1016/j.bmcl.2016.06.014 | |||
18630945 | 171095 | None | 1 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 507 | 9 | 1 | 9 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OC | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4456288 | 171095 | None | 1 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 507 | 9 | 1 | 9 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OC | 10.1016/j.bmcl.2016.06.014 | |||
155542285 | 173180 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 522 | 14 | 2 | 11 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1cccc(OC)c1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4519822 | 173180 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 522 | 14 | 2 | 11 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1cccc(OC)c1 | 10.1016/j.bmcl.2016.06.014 | |||
11477084 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
216235 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
3548 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
3950 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
CHEMBL282724 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
DB06268 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
22467234 | 85387 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 534 | 7 | 1 | 8 | 4.1 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(C)=O)ccc12 | 10.1007/s00044-004-0021-y | |||
CHEMBL2261599 | 85387 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 534 | 7 | 1 | 8 | 4.1 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(C)=O)ccc12 | 10.1007/s00044-004-0021-y | |||
21041372 | 81731 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 687 | 14 | 2 | 12 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(N2CCOCC2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163725 | 81731 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 687 | 14 | 2 | 12 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(N2CCOCC2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
21041370 | 82033 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 636 | 13 | 2 | 10 | 4.4 | COc1ccc(Cl)c(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1021/jm3009103 | |||
CHEMBL2165330 | 82033 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 636 | 13 | 2 | 10 | 4.4 | COc1ccc(Cl)c(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1021/jm3009103 | |||
21979593 | 82036 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 590 | 11 | 2 | 8 | 4.3 | O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 | 10.1021/jm3009103 | |||
CHEMBL2165333 | 82036 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 590 | 11 | 2 | 8 | 4.3 | O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 | 10.1021/jm3009103 | |||
44295177 | 14787 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 534 | 10 | 1 | 9 | 5.0 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL1206680 | 14787 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 534 | 10 | 1 | 9 | 5.0 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL295483 | 14787 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 534 | 10 | 1 | 9 | 5.0 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C | 10.1016/s0960-894x(98)00301-1 | |||
104865 | 706 | None | 60 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | |||
104865.0 | 706 | None | 60 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | |||
3494 | 706 | None | 60 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | |||
392 | 706 | None | 60 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | |||
CHEMBL957 | 706 | None | 60 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | |||
DB00559 | 706 | None | 60 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | |||
10952199 | 10025 | None | 0 | Pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 609 | 9 | 1 | 8 | 5.3 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(F)(F)F)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL115017 | 10025 | None | 0 | Pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 609 | 9 | 1 | 8 | 5.3 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(F)(F)F)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
11477084 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | |||
216235 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | |||
3548 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | |||
3950 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | |||
CHEMBL282724 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | |||
DB06268 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | |||
11477084 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
216235 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
3548 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
3950 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
CHEMBL282724 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
DB06268 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm030528p | |||
11477084 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm000349x | |||
216235 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm000349x | |||
3548 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm000349x | |||
3950 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm000349x | |||
CHEMBL282724 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm000349x | |||
DB06268 | 3610 | None | 36 | Human | Binding | pIC50 | = | 8.9 | 8.9 | 1 | 2 | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm000349x | |||
42630655 | 18414 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 557 | 11 | 2 | 7 | 5.5 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | |||
CHEMBL1271586 | 18414 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 557 | 11 | 2 | 7 | 5.5 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | |||
11409462 | 201144 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 501 | 6 | 2 | 6 | 6.0 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ccccc2)c1 | 10.1021/jm030528p | |||
CHEMBL58058 | 201144 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 501 | 6 | 2 | 6 | 6.0 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ccccc2)c1 | 10.1021/jm030528p | |||
10505771 | 163451 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | |||
CHEMBL419211 | 163451 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | |||
11026025 | 205343 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 412 | 7 | 1 | 6 | 4.6 | CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL62669 | 205343 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 412 | 7 | 1 | 6 | 4.6 | CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
10649122 | 9741 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 502 | 12 | 1 | 4 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL113400 | 9741 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 502 | 12 | 1 | 4 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
10505771 | 163451 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL419211 | 163451 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
21041297 | 169710 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 510 | 12 | 2 | 9 | 3.4 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4436531 | 169710 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 510 | 12 | 2 | 9 | 3.4 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
71453357 | 81713 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 707 | 12 | 1 | 12 | 5.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163708 | 81713 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 707 | 12 | 1 | 12 | 5.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
159594 | 522 | None | 36 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1016/s0960-894x(98)00301-1 | |||
159594.0 | 522 | None | 36 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1016/s0960-894x(98)00301-1 | |||
3487 | 522 | None | 36 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL9194 | 522 | None | 36 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1016/s0960-894x(98)00301-1 | |||
DB06199 | 522 | None | 36 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -1 | 3 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1016/s0960-894x(98)00301-1 | |||
44279303 | 107152 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 576 | 11 | 2 | 7 | 4.3 | COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
CHEMBL31592 | 107152 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 576 | 11 | 2 | 7 | 4.3 | COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
10302092 | 111400 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 532 | 12 | 1 | 7 | 3.7 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC | 10.1021/jm970101g | |||
CHEMBL326861 | 111400 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 532 | 12 | 1 | 7 | 3.7 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC | 10.1021/jm970101g | |||
10768903 | 12138 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 544 | 11 | 2 | 6 | 5.3 | CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | |||
CHEMBL1184133 | 12138 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 544 | 11 | 2 | 6 | 5.3 | CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | |||
CHEMBL334076 | 12138 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 544 | 11 | 2 | 6 | 5.3 | CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | |||
11733231 | 205302 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)c1 | 10.1021/jm010382z | |||
CHEMBL62465 | 205302 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)c1 | 10.1021/jm010382z | |||
9872534 | 176127 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 521 | 11 | 2 | 10 | 3.5 | COc1ccccc1Oc1c(NS(=O)(=O)/C=C/c2ccccc2)nc(-c2ncccn2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4590018 | 176127 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 521 | 11 | 2 | 10 | 3.5 | COc1ccccc1Oc1c(NS(=O)(=O)/C=C/c2ccccc2)nc(-c2ncccn2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
44439103 | 91985 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 859 | 27 | 2 | 14 | 5.3 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 | 10.1016/j.bmcl.2006.10.009 | |||
CHEMBL241460 | 91985 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 859 | 27 | 2 | 14 | 5.3 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 | 10.1016/j.bmcl.2006.10.009 | |||
67952994 | 82037 | None | 15 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 634 | 11 | 2 | 8 | 4.4 | O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
CHEMBL2165334 | 82037 | None | 15 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 634 | 11 | 2 | 8 | 4.4 | O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
19689505 | 58931 | None | 0 | Pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 639 | 11 | 1 | 8 | 6.5 | CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(-c2ccc(C)cc2)c(OCCOc2ncc(Br)cn2)n1 | 10.1016/s0960-894x(01)00682-5 | |||
CHEMBL168904 | 58931 | None | 0 | Pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 639 | 11 | 1 | 8 | 6.5 | CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(-c2ccc(C)cc2)c(OCCOc2ncc(Br)cn2)n1 | 10.1016/s0960-894x(01)00682-5 | |||
44334065 | 167925 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 429 | 5 | 1 | 5 | 4.7 | COc1ccc([C@@H]2c3nc(C4CC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL430695 | 167925 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 429 | 5 | 1 | 5 | 4.7 | COc1ccc([C@@H]2c3nc(C4CC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
10719367 | 98283 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)cc(OC)c2)cc1 | 10.1021/jm9606507 | |||
CHEMBL274359 | 98283 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)cc(OC)c2)cc1 | 10.1021/jm9606507 | |||
12286 | 948 | None | 29 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1348 | 2 | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | |||
6433095 | 948 | None | 29 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1348 | 2 | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | |||
6433095.0 | 948 | None | 29 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1348 | 2 | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL109648 | 948 | None | 29 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1348 | 2 | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | |||
DB06677 | 948 | None | 29 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1348 | 2 | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | |||
22467237 | 85377 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 549 | 8 | 3 | 8 | 2.3 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(CC(=O)O)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1007/s00044-004-0021-y | |||
CHEMBL2261357 | 85377 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 549 | 8 | 3 | 8 | 2.3 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(CC(=O)O)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1007/s00044-004-0021-y | |||
71455063 | 81726 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 646 | 15 | 2 | 12 | 3.8 | CCCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | |||
CHEMBL2163720 | 81726 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 646 | 15 | 2 | 12 | 3.8 | CCCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | |||
21041267 | 82040 | None | 15 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 558 | 9 | 2 | 8 | 2.8 | CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
CHEMBL2165337 | 82040 | None | 15 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 558 | 9 | 2 | 8 | 2.8 | CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
10813261 | 60447 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm031041j | |||
CHEMBL175129 | 60447 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm031041j | |||
9955200 | 9334 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | |||
CHEMBL11115 | 9334 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | |||
10601668 | 98499 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)cc2OC)cc1 | 10.1021/jm9606507 | |||
CHEMBL275701 | 98499 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)cc2OC)cc1 | 10.1021/jm9606507 | |||
10973523 | 205319 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 537 | 7 | 1 | 8 | 4.2 | COc1ccc(C2=C(C(=O)NS(C)(=O)=O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL62578 | 205319 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 537 | 7 | 1 | 8 | 4.2 | COc1ccc(C2=C(C(=O)NS(C)(=O)=O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
11122785 | 205433 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 426 | 8 | 1 | 6 | 4.6 | COCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL63057 | 205433 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 426 | 8 | 1 | 6 | 4.6 | COCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
10649546 | 108670 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 516 | 13 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCCO1 | 10.1021/jm980217s | |||
CHEMBL320569 | 108670 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 516 | 13 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCCO1 | 10.1021/jm980217s | |||
CHEMBL2304015 | 211930 | None | 0 | Pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O | 10.1021/jm9600914 | |||||
10029171 | 98819 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 505 | 6 | 2 | 7 | 3.0 | Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | |||
CHEMBL278109 | 98819 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 505 | 6 | 2 | 7 | 3.0 | Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | |||
11800804 | 161930 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 550 | 10 | 4 | 5 | 4.7 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | |||
CHEMBL414605 | 161930 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 550 | 10 | 4 | 5 | 4.7 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | |||
42630655 | 18414 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 557 | 11 | 2 | 7 | 5.5 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
CHEMBL1271586 | 18414 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 557 | 11 | 2 | 7 | 5.5 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
10504475 | 209410 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 468 | 8 | 1 | 6 | 3.4 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)C)cc1 | 10.1021/jm9505369 | |||
CHEMBL9119 | 209410 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 468 | 8 | 1 | 6 | 3.4 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)C)cc1 | 10.1021/jm9505369 | |||
71456863 | 81721 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL2163716 | 81721 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1016/j.bmcl.2016.06.014 | |||
10971938 | 205434 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 424 | 7 | 1 | 5 | 5.6 | CC(C)CCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL63058 | 205434 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 424 | 7 | 1 | 5 | 5.6 | CC(C)CCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
44315008 | 102886 | None | 0 | Pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 665 | 13 | 5 | 5 | 4.7 | CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL305524 | 102886 | None | 0 | Pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 665 | 13 | 5 | 5 | 4.7 | CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
71453356 | 81696 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 554 | 13 | 2 | 10 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cccc(OC)c1 | 10.1021/jm3009103 | |||
CHEMBL2163691 | 81696 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 554 | 13 | 2 | 10 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cccc(OC)c1 | 10.1021/jm3009103 | |||
71456863 | 81721 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163716 | 81721 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
11827768 | 9877 | None | 0 | Pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 551 | 11 | 1 | 10 | 4.6 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)c1 | 10.1021/jm0102304 | |||
CHEMBL114201 | 9877 | None | 0 | Pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 551 | 11 | 1 | 10 | 4.6 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)c1 | 10.1021/jm0102304 | |||
44387543 | 60582 | None | 0 | Pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 759 | 9 | 1 | 9 | 8.1 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Cl)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1.O=C1C2=C(CCCC2)c2ccccc21 | 10.1021/jm0102304 | |||
CHEMBL175931 | 60582 | None | 0 | Pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 759 | 9 | 1 | 9 | 8.1 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Cl)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1.O=C1C2=C(CCCC2)c2ccccc21 | 10.1021/jm0102304 | |||
44334129 | 108610 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 459 | 8 | 1 | 5 | 5.5 | CCCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL320208 | 108610 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 459 | 8 | 1 | 5 | 5.5 | CCCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | |||
10507467 | 8502 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 580 | 12 | 1 | 7 | 4.5 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)Cc1ccccc1 | 10.1021/jm970101g | |||
CHEMBL109408 | 8502 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 580 | 12 | 1 | 7 | 4.5 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)Cc1ccccc1 | 10.1021/jm970101g | |||
10118046 | 9438 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 504 | 10 | 1 | 7 | 2.9 | CCCS(=O)(=O)N(C)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | |||
CHEMBL111728 | 9438 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 504 | 10 | 1 | 7 | 2.9 | CCCS(=O)(=O)N(C)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | |||
10597575 | 6898 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 408 | 5 | 1 | 6 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCC2)cc1 | 10.1021/jm9606507 | |||
CHEMBL10843 | 6898 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 408 | 5 | 1 | 6 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCC2)cc1 | 10.1021/jm9606507 | |||
10671928 | 7278 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 467 | 5 | 1 | 7 | 4.4 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2nccc3ccccc23)cc1 | 10.1021/jm9606507 | |||
CHEMBL10860 | 7278 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 467 | 5 | 1 | 7 | 4.4 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2nccc3ccccc23)cc1 | 10.1021/jm9606507 | |||
10791988 | 8585 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 516 | 13 | 1 | 6 | 4.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCOCC1 | 10.1021/jm980217s | |||
CHEMBL109474 | 8585 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 516 | 13 | 1 | 6 | 4.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCOCC1 | 10.1021/jm980217s | |||
10792934 | 164008 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 558 | 10 | 2 | 6 | 5.6 | CCc1cc(CC)c(NC(=O)CN2C[C@H](c3ccc4c(c3)OCO4)[C@@H](C(=O)O)[C@@H]2c2ccc(OC)cc2)c(CC)c1 | 10.1021/jm990170q | |||
CHEMBL420729 | 164008 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 558 | 10 | 2 | 6 | 5.6 | CCc1cc(CC)c(NC(=O)CN2C[C@H](c3ccc4c(c3)OCO4)[C@@H](C(=O)O)[C@@H]2c2ccc(OC)cc2)c(CC)c1 | 10.1021/jm990170q | |||
9939960 | 175679 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 704 | 13 | 2 | 11 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)cc(C(=O)N2CCN(C)CC2)cc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4579445 | 175679 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 704 | 13 | 2 | 11 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)cc(C(=O)N2CCN(C)CC2)cc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | |||
127035070 | 136559 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 647 | 11 | 2 | 7 | 7.3 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
CHEMBL3735931 | 136559 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 647 | 11 | 2 | 7 | 7.3 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
127036865 | 137511 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 584 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
CHEMBL3753406 | 137511 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 584 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
9875246 | 120373 | None | 0 | Pig | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 733 | 15 | 2 | 12 | 6.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCC(=O)O)nc1OCCOc1ncc(Br)cn1 | 10.1016/s0960-894x(01)00682-5 | |||
CHEMBL352775 | 120373 | None | 0 | Pig | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 733 | 15 | 2 | 12 | 6.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCC(=O)O)nc1OCCOc1ncc(Br)cn1 | 10.1016/s0960-894x(01)00682-5 | |||
10696210 | 99602 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 483 | 6 | 2 | 9 | 3.7 | CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm9608366 | |||
CHEMBL283535 | 99602 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 483 | 6 | 2 | 9 | 3.7 | CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm9608366 | |||
44291884 | 173001 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 483 | 6 | 2 | 9 | 3.7 | CC(=O)c1c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)ccc2c1OCO2 | 10.1021/jm9700068 | |||
CHEMBL45160 | 173001 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 483 | 6 | 2 | 9 | 3.7 | CC(=O)c1c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)ccc2c1OCO2 | 10.1021/jm9700068 | |||
10671037 | 131512 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
CHEMBL273660 | 131512 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
CHEMBL369085 | 131512 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
10673756 | 205920 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 529 | 9 | 1 | 8 | 4.3 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN3CCCC3)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL65939 | 205920 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 529 | 9 | 1 | 8 | 4.3 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN3CCCC3)c2)cc1 | 10.1021/jm980504w | |||
10475644 | 205590 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 392 | 5 | 1 | 6 | 3.2 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 | 10.1021/jm9604585 | |||
CHEMBL6412 | 205590 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 392 | 5 | 1 | 6 | 3.2 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 | 10.1021/jm9604585 | |||
10696210 | 99602 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 483 | 6 | 2 | 9 | 3.7 | CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm000349x | |||
CHEMBL283535 | 99602 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 483 | 6 | 2 | 9 | 3.7 | CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm000349x | |||
71456862 | 81714 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 651 | 12 | 1 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163709 | 81714 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 651 | 12 | 1 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
44291583 | 101445 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 500 | 8 | 3 | 9 | 2.9 | COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 | 10.1021/jm9608366 | |||
CHEMBL297215 | 101445 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 500 | 8 | 3 | 9 | 2.9 | COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 | 10.1021/jm9608366 | |||
44278215 | 99612 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 491 | 5 | 1 | 9 | 4.7 | O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL283598 | 99612 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 491 | 5 | 1 | 9 | 4.7 | O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 | 10.1016/0960-894X(96)00232-6 | |||
10841576 | 11447 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 620 | 11 | 2 | 6 | 6.3 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC | 10.1021/jm990171i | |||
CHEMBL1180336 | 11447 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 620 | 11 | 2 | 6 | 6.3 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC | 10.1021/jm990171i | |||
CHEMBL122673 | 11447 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 620 | 11 | 2 | 6 | 6.3 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC | 10.1021/jm990171i | |||
CHEMBL94907 | 218404 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | |||||
CHEMBL2304010 | 211925 | None | 0 | Pig | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | None | None | None | CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Cl)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O | 10.1021/jm9600914 | |||||
10792316 | 168585 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 530 | 8 | 2 | 6 | 5.3 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C(C)C)cc1 | 10.1021/jm990170q | |||
CHEMBL435185 | 168585 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 530 | 8 | 2 | 6 | 5.3 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C(C)C)cc1 | 10.1021/jm990170q | |||
18738890 | 99201 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 548 | 7 | 1 | 8 | 4.5 | COC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)cn(C)c2c1 | 10.1016/s0960-894x(01)00660-6 | |||
CHEMBL281121 | 99201 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 548 | 7 | 1 | 8 | 4.5 | COC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)cn(C)c2c1 | 10.1016/s0960-894x(01)00660-6 | |||
23445498 | 209158 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 426 | 4 | 1 | 5 | 4.9 | Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL89688 | 209158 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 426 | 4 | 1 | 5 | 4.9 | Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(96)00496-9 | |||
10265127 | 96889 | None | 1 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 270 | 3 | 1 | 4 | 2.2 | Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C | 10.1021/jm00008a013 | |||
CHEMBL26522 | 96889 | None | 1 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 270 | 3 | 1 | 4 | 2.2 | Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C | 10.1021/jm00008a013 | |||
CHEMBL315047 | 213645 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
44327659 | 109878 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 937 | 26 | 9 | 8 | 4.6 | CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 | 10.1021/jm00015a003 | |||
CHEMBL323331 | 109878 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 937 | 26 | 9 | 8 | 4.6 | CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 | 10.1021/jm00015a003 | |||
CHEMBL318020 | 213668 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | |||||
44316685 | 207506 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 266 | 3 | 1 | 4 | 2.4 | Cc1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL77090 | 207506 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 266 | 3 | 1 | 4 | 2.4 | Cc1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | |||
10022291 | 112091 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 374 | 9 | 1 | 3 | 5.1 | O=C(O)CCC(C(=O)c1cccc(OCc2ccccc2)c1)c1ccccc1 | 10.1021/jm970847e | |||
CHEMBL328964 | 112091 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 374 | 9 | 1 | 3 | 5.1 | O=C(O)CCC(C(=O)c1cccc(OCc2ccccc2)c1)c1ccccc1 | 10.1021/jm970847e | |||
12060119 | 110447 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 441 | 7 | 2 | 6 | 3.9 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL324304 | 110447 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 441 | 7 | 2 | 6 | 3.9 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
4568158 | 111470 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 400 | 8 | 2 | 4 | 4.9 | O=C(O)c1cc(-c2ccc(OCc3ccccc3)cc2OCc2ccccc2)[nH]n1 | 10.1021/jm9707131 | |||
CHEMBL327247 | 111470 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 400 | 8 | 2 | 4 | 4.9 | O=C(O)c1cc(-c2ccc(OCc3ccccc3)cc2OCc2ccccc2)[nH]n1 | 10.1021/jm9707131 | |||
CHEMBL315047 | 213645 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | |||||
10568280 | 205561 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 328 | 4 | 1 | 5 | 2.5 | CN(C)c1cccc2c(S(=O)(=O)Nc3cnccn3)cccc12 | 10.1021/jm9604585 | |||
CHEMBL6399 | 205561 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 328 | 4 | 1 | 5 | 2.5 | CN(C)c1cccc2c(S(=O)(=O)Nc3cnccn3)cccc12 | 10.1021/jm9604585 | |||
10553319 | 61088 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 496 | 11 | 5 | 4 | 3.8 | CCN(CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C)[nH]1 | 10.1021/jm950592+ | |||
CHEMBL176430 | 61088 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 496 | 11 | 5 | 4 | 3.8 | CCN(CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C)[nH]1 | 10.1021/jm950592+ | |||
10006086 | 121126 | None | 0 | Pig | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 498 | 9 | 2 | 5 | 4.6 | COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | |||
CHEMBL356916 | 121126 | None | 0 | Pig | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 498 | 9 | 2 | 5 | 4.6 | COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | |||
10381122 | 99251 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 317 | 3 | 2 | 5 | 2.8 | Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C | 10.1021/jm00008a013 | |||
CHEMBL281427 | 99251 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 317 | 3 | 2 | 5 | 2.8 | Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C | 10.1021/jm00008a013 | |||
44327466 | 96504 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 966 | 25 | 9 | 8 | 5.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(C)(C)C)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||
CHEMBL262229 | 96504 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 966 | 25 | 9 | 8 | 5.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(C)(C)C)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||
18617385 | 207670 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 286 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1C | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL78601 | 207670 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 286 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1C | 10.1016/0960-894X(96)00441-6 | |||
127029201 | 137345 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 644 | 12 | 3 | 9 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
CHEMBL3751994 | 137345 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 644 | 12 | 3 | 9 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
3080568 | 178951 | None | 28 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 348 | 5 | 3 | 7 | 2.7 | COC(=O)c1cc(O)cc(OC)c1Oc1cc(C)cc(O)c1C(=O)O | 10.1021/np0102758 | |||
CHEMBL469424 | 178951 | None | 28 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 348 | 5 | 3 | 7 | 2.7 | COC(=O)c1cc(O)cc(OC)c1Oc1cc(C)cc(O)c1C(=O)O | 10.1021/np0102758 | |||
9846065 | 171022 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 439 | 7 | 2 | 6 | 3.6 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4455096 | 171022 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 439 | 7 | 2 | 6 | 3.6 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
44276947 | 106907 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 430 | 5 | 1 | 3 | 5.2 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)c(Cl)c3)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144803 | 106907 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 430 | 5 | 1 | 3 | 5.2 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)c(Cl)c3)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
44276907 | 106911 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 376 | 4 | 1 | 4 | 3.6 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144845 | 106911 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 376 | 4 | 1 | 4 | 3.6 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1 | 10.1016/s0960-894x(00)00232-8 | |||
10381122 | 99251 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 317 | 3 | 2 | 5 | 2.8 | Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C | 10.1021/jm00004a012 | |||
CHEMBL281427 | 99251 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 317 | 3 | 2 | 5 | 2.8 | Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C | 10.1021/jm00004a012 | |||
3765218 | 205879 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 419 | 4 | 1 | 4 | 4.2 | Cc1nc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)ccc1Br | 10.1021/jm9604585 | |||
CHEMBL6566 | 205879 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 419 | 4 | 1 | 4 | 4.2 | Cc1nc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)ccc1Br | 10.1021/jm9604585 | |||
44266649 | 98163 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 391 | 3 | 1 | 4 | 5.4 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(Cl)ccc2n1-c1ccccc1 | 10.1016/0960-894X(96)00170-9 | |||
CHEMBL273488 | 98163 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 391 | 3 | 1 | 4 | 5.4 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(Cl)ccc2n1-c1ccccc1 | 10.1016/0960-894X(96)00170-9 | |||
23445421 | 59950 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 454 | 6 | 1 | 5 | 5.0 | Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | |||
CHEMBL173189 | 59950 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 454 | 6 | 1 | 5 | 5.0 | Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | |||
10832763 | 168542 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 366 | 4 | 2 | 6 | 2.3 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Br | 10.1016/S0960-894X(97)00367-3 | |||
CHEMBL434983 | 168542 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 366 | 4 | 2 | 6 | 2.3 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Br | 10.1016/S0960-894X(97)00367-3 | |||
137649809 | 157479 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 583 | 10 | 2 | 7 | 5.9 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
CHEMBL4078297 | 157479 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 583 | 10 | 2 | 7 | 5.9 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
10527774 | 183794 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 455 | 5 | 2 | 6 | 4.2 | Cc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1021/jm9608366 | |||
CHEMBL48031 | 183794 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 455 | 5 | 2 | 6 | 4.2 | Cc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1021/jm9608366 | |||
22998456 | 59814 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 514 | 8 | 1 | 8 | 4.9 | CCCc1cc2c(cc1OCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00132-7 | |||
CHEMBL172666 | 59814 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 514 | 8 | 1 | 8 | 4.9 | CCCc1cc2c(cc1OCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00132-7 | |||
9874379 | 60466 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 653 | 14 | 2 | 10 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL175268 | 60466 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 653 | 14 | 2 | 10 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | |||
10718385 | 209269 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 450 | 7 | 1 | 6 | 2.4 | C#CCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9040 | 209269 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 450 | 7 | 1 | 6 | 2.4 | C#CCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
23445593 | 60255 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 440 | 6 | 1 | 5 | 4.7 | Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00133-9 | |||
CHEMBL174086 | 60255 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 440 | 6 | 1 | 5 | 4.7 | Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00133-9 | |||
10805820 | 206175 | None | 41 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 322 | 4 | 2 | 6 | 2.2 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Cl | 10.1016/S0960-894X(97)00367-3 | |||
CHEMBL67664 | 206175 | None | 41 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 322 | 4 | 2 | 6 | 2.2 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Cl | 10.1016/S0960-894X(97)00367-3 | |||
10812400 | 98432 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 427 | 9 | 1 | 6 | 3.7 | CCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL275306 | 98432 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 427 | 9 | 1 | 6 | 3.7 | CCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
44265853 | 208860 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 454 | 4 | 1 | 6 | 2.7 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)N2CCOCC2)cc1 | 10.1021/jm9505369 | |||
CHEMBL8776 | 208860 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 454 | 4 | 1 | 6 | 2.7 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)N2CCOCC2)cc1 | 10.1021/jm9505369 | |||
10854399 | 205458 | None | 26 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 336 | 4 | 1 | 7 | 2.3 | COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1016/S0960-894X(97)00367-3 | |||
CHEMBL63169 | 205458 | None | 26 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 336 | 4 | 1 | 7 | 2.3 | COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1016/S0960-894X(97)00367-3 | |||
10647020 | 61315 | None | 0 | Rat | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1OC | 10.1021/jm031041j | |||
CHEMBL176696 | 61315 | None | 0 | Rat | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1OC | 10.1021/jm031041j | |||
10647021 | 6976 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1OC | 10.1021/jm9606507 | |||
CHEMBL10846 | 6976 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1OC | 10.1021/jm9606507 | |||
10552548 | 98575 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2OC)cc1 | 10.1021/jm9606507 | |||
CHEMBL276252 | 98575 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2OC)cc1 | 10.1021/jm9606507 | |||
9934580 | 163025 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 474 | 6 | 1 | 8 | 3.6 | COC(=O)c1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | |||
CHEMBL417428 | 163025 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 474 | 6 | 1 | 8 | 3.6 | COC(=O)c1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | |||
127035757 | 136592 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 591 | 10 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
CHEMBL3736242 | 136592 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 591 | 10 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
76308472 | 85388 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 517 | 6 | 1 | 8 | 3.7 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C#N)ccc12 | 10.1007/s00044-004-0021-y | |||
CHEMBL2261600 | 85388 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 517 | 6 | 1 | 8 | 3.7 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C#N)ccc12 | 10.1007/s00044-004-0021-y | |||
44320338 | 107030 | None | 0 | Rat | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 490 | 7 | 2 | 6 | 5.0 | O=C(O)c1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL315087 | 107030 | None | 0 | Rat | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 490 | 7 | 2 | 6 | 5.0 | O=C(O)c1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc1 | 10.1016/s0960-894x(00)00513-8 | |||
44385162 | 61401 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 533 | 10 | 2 | 10 | 3.3 | C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL176963 | 61401 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 533 | 10 | 2 | 10 | 3.3 | C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
10697633 | 60354 | None | 0 | Rat | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 536 | 10 | 5 | 5 | 4.4 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL174448 | 60354 | None | 0 | Rat | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 536 | 10 | 5 | 5 | 4.4 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm950592+ | |||
10697633 | 60354 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 536 | 10 | 5 | 5 | 4.4 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | |||
CHEMBL174448 | 60354 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 536 | 10 | 5 | 5 | 4.4 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | |||
10551548 | 127885 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 450 | 7 | 1 | 5 | 5.0 | COc1ccc(C(=O)/C(Cc2ccc(Cl)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm031041j | |||
CHEMBL366442 | 127885 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 450 | 7 | 1 | 5 | 5.0 | COc1ccc(C(=O)/C(Cc2ccc(Cl)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm031041j | |||
11732966 | 205629 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 444 | 5 | 1 | 5 | 5.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 | 10.1021/jm031041j | |||
CHEMBL64244 | 205629 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 444 | 5 | 1 | 5 | 5.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 | 10.1021/jm031041j | |||
CHEMBL302776 | 213374 | None | 0 | Pig | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00089a028 | |||||
22616262 | 207997 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 366 | 3 | 1 | 4 | 3.7 | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL80980 | 207997 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 366 | 3 | 1 | 4 | 3.7 | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1Br | 10.1016/0960-894X(96)00441-6 | |||
18617351 | 104164 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 384 | 3 | 1 | 4 | 3.9 | Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL309397 | 104164 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 384 | 3 | 1 | 4 | 3.9 | Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1Br | 10.1016/0960-894X(96)00441-6 | |||
10433234 | 207905 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 436 | 5 | 1 | 4 | 4.3 | CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL80342 | 207905 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 436 | 5 | 1 | 4 | 4.3 | CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | |||
11744509 | 5432 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 450 | 5 | 1 | 6 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 | 10.1021/jm9606507 | |||
CHEMBL10733 | 5432 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 450 | 5 | 1 | 6 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 | 10.1021/jm9606507 | |||
11732966 | 205629 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 444 | 5 | 1 | 5 | 5.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL64244 | 205629 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 444 | 5 | 1 | 5 | 5.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 | 10.1021/jm010382z | |||
54587165 | 60329 | None | 0 | Pig | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 675 | 15 | 5 | 4 | 5.9 | CCCCCC[C@@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL1744023 | 60329 | None | 0 | Pig | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 675 | 15 | 5 | 4 | 5.9 | CCCCCC[C@@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
44293932 | 163241 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 521 | 10 | 2 | 8 | 3.9 | CCOc1ccc2c(c1)[C@H](c1cccc(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | |||
CHEMBL417903 | 163241 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 521 | 10 | 2 | 8 | 3.9 | CCOc1ccc2c(c1)[C@H](c1cccc(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | |||
15304942 | 164525 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 394 | 9 | 1 | 4 | 5.5 | Cc1ccccc1C(CCC(=O)O)C(=O)c1cccc(OCc2ccsc2)c1 | 10.1021/jm9707131 | |||
CHEMBL421365 | 164525 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 394 | 9 | 1 | 4 | 5.5 | Cc1ccccc1C(CCC(=O)O)C(=O)c1cccc(OCc2ccsc2)c1 | 10.1021/jm9707131 | |||
44213279 | 106904 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 456 | 6 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144737 | 106904 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 456 | 6 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
10554748 | 60094 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 552 | 10 | 6 | 6 | 3.3 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(O)CC2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL173826 | 60094 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 552 | 10 | 6 | 6 | 3.3 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(O)CC2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL335143 | 214005 | None | 0 | Pig | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
44382975 | 120397 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 596 | 11 | 4 | 7 | 3.7 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCc1nc(C(=O)O)cs1 | 10.1016/0960-894X(95)00144-I | |||
CHEMBL352929 | 120397 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 596 | 11 | 4 | 7 | 3.7 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCc1nc(C(=O)O)cs1 | 10.1016/0960-894X(95)00144-I | |||
10440821 | 209997 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 918 | 24 | 9 | 8 | 4.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c(C)c(C)c(C)c(C)c1C)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||
CHEMBL94689 | 209997 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 918 | 24 | 9 | 8 | 4.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c(C)c(C)c(C)c(C)c1C)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||
10620470 | 111582 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 391 | 7 | 1 | 5 | 4.8 | COc1cccc(/C(=C\c2cc(OCc3ccsc3)ccc2C#N)C(=O)O)c1 | 10.1021/jm970847e | |||
CHEMBL327861 | 111582 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 391 | 7 | 1 | 5 | 4.8 | COc1cccc(/C(=C\c2cc(OCc3ccsc3)ccc2C#N)C(=O)O)c1 | 10.1021/jm970847e | |||
44293915 | 192655 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 507 | 9 | 1 | 8 | 4.4 | CCOc1ccc2c(c1)[C@H](c1cc(OC)c(OC)c(OC)c1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | |||
CHEMBL52110 | 192655 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 507 | 9 | 1 | 8 | 4.4 | CCOc1ccc2c(c1)[C@H](c1cc(OC)c(OC)c(OC)c1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | |||
44291495 | 11237 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 455 | 6 | 2 | 9 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl | 10.1021/jm9700068 | |||
CHEMBL1178832 | 11237 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 455 | 6 | 2 | 9 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl | 10.1021/jm9700068 | |||
CHEMBL45351 | 11237 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 455 | 6 | 2 | 9 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl | 10.1021/jm9700068 | |||
44266565 | 98287 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 417 | 5 | 1 | 6 | 4.7 | COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OC)cc23)cc1 | 10.1016/0960-894X(96)00170-9 | |||
CHEMBL274370 | 98287 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 417 | 5 | 1 | 6 | 4.7 | COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OC)cc23)cc1 | 10.1016/0960-894X(96)00170-9 | |||
44311225 | 207165 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 581 | 11 | 1 | 10 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1ccoc1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL74118 | 207165 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 581 | 11 | 1 | 10 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1ccoc1 | 10.1016/S0960-894X(97)00400-9 | |||
13044638 | 85872 | None | 16 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 206 | 2 | 1 | 3 | 2.4 | COc1cccc2oc(C(=O)O)c(C)c12 | 10.1007/s00044-013-0542-3 | |||
CHEMBL2296888 | 85872 | None | 16 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 206 | 2 | 1 | 3 | 2.4 | COc1cccc2oc(C(=O)O)c(C)c12 | 10.1007/s00044-013-0542-3 | |||
CHEMBL269428 | 213246 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
10769177 | 112975 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 558 | 11 | 2 | 6 | 5.2 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCOC)cc1 | 10.1021/jm990170q | |||
CHEMBL331066 | 112975 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 558 | 11 | 2 | 6 | 5.2 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCOC)cc1 | 10.1021/jm990170q | |||
127026338 | 137491 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
CHEMBL3753277 | 137491 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
120533 | 101685 | None | 6 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 379 | 3 | 2 | 5 | 2.0 | Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1I | 10.1016/s0960-894x(00)00366-8 | |||
CHEMBL298976 | 101685 | None | 6 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 379 | 3 | 2 | 5 | 2.0 | Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1I | 10.1016/s0960-894x(00)00366-8 | |||
10674532 | 168691 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 567 | 10 | 4 | 5 | 5.8 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)s1 | 10.1021/jm950591h | |||
CHEMBL435894 | 168691 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 567 | 10 | 4 | 5 | 5.8 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)s1 | 10.1021/jm950591h | |||
10452089 | 4567 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 375 | 3 | 0 | 5 | 4.1 | COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL102494 | 4567 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 375 | 3 | 0 | 5 | 4.1 | COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 | 10.1016/S0960-894X(96)00551-3 | |||
10095637 | 49981 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00186-W | |||
CHEMBL15689 | 49981 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00186-W | |||
19385674 | 98642 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 715 | 13 | 1 | 7 | 8.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br | 10.1016/0960-894X(95)00186-W | |||
CHEMBL276819 | 98642 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 715 | 13 | 1 | 7 | 8.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br | 10.1016/0960-894X(95)00186-W | |||
19385674 | 98642 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 715 | 13 | 1 | 7 | 8.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br | 10.1021/jm058225d | |||
CHEMBL276819 | 98642 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 715 | 13 | 1 | 7 | 8.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br | 10.1021/jm058225d | |||
44266538 | 5467 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 371 | 4 | 1 | 4 | 4.8 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccccc1 | 10.1016/0960-894X(96)00170-9 | |||
CHEMBL10750 | 5467 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 371 | 4 | 1 | 4 | 4.8 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccccc1 | 10.1016/0960-894X(96)00170-9 | |||
11798999 | 210044 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 482 | 7 | 1 | 6 | 3.8 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)(C)C)cc1 | 10.1021/jm9505369 | |||
CHEMBL9495 | 210044 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 482 | 7 | 1 | 6 | 3.8 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)(C)C)cc1 | 10.1021/jm9505369 | |||
71460536 | 81717 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 589 | 11 | 1 | 12 | 3.1 | COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163712 | 81717 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 589 | 11 | 1 | 12 | 3.1 | COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
10669120 | 209904 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 407 | 9 | 1 | 5 | 5.5 | Cc1ccccc1[C@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N | 10.1021/jm9707131 | |||
CHEMBL94141 | 209904 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 407 | 9 | 1 | 5 | 5.5 | Cc1ccccc1[C@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N | 10.1021/jm9707131 | |||
23445366 | 106239 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 482 | 7 | 1 | 5 | 6.2 | Cc1cc(CCC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL313801 | 106239 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 482 | 7 | 1 | 5 | 6.2 | Cc1cc(CCC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
52949197 | 18431 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 555 | 10 | 2 | 7 | 5.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | |||
CHEMBL1271746 | 18431 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 555 | 10 | 2 | 7 | 5.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | |||
10694591 | 9228 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 444 | 6 | 1 | 6 | 4.6 | CC(C)Oc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | |||
CHEMBL11064 | 9228 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 444 | 6 | 1 | 6 | 4.6 | CC(C)Oc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | |||
18184194 | 130630 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 2 | ChEMBL | 712 | 15 | 2 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL368107 | 130630 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 2 | ChEMBL | 712 | 15 | 2 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | |||
9998577 | 98155 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 359 | 5 | 1 | 5 | 3.6 | CCc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL27344 | 98155 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 359 | 5 | 1 | 5 | 3.6 | CCc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL327350 | 213749 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | |||||
18184228 | 61373 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 604 | 13 | 2 | 9 | 4.6 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL176749 | 61373 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 604 | 13 | 2 | 9 | 4.6 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
10342643 | 5159 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm9606507 | |||
CHEMBL10588 | 5159 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm9606507 | |||
10791694 | 98253 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2OC)cc1 | 10.1021/jm9606507 | |||
CHEMBL274175 | 98253 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2OC)cc1 | 10.1021/jm9606507 | |||
11058202 | 205281 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 388 | 4 | 1 | 5 | 4.4 | CC(C)Oc1ccc2c(c1)C(Cl)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
CHEMBL62374 | 205281 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 388 | 4 | 1 | 5 | 4.4 | CC(C)Oc1ccc2c(c1)C(Cl)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
11799636 | 109320 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 502 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCO1 | 10.1021/jm980217s | |||
CHEMBL321831 | 109320 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 502 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCO1 | 10.1021/jm980217s | |||
10626646 | 16453 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCc1cccc(CCC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | |||
CHEMBL123305 | 16453 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCc1cccc(CCC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | |||
10224745 | 112753 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 432 | 5 | 2 | 6 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL330425 | 112753 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 432 | 5 | 2 | 6 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1016/j.bmcl.2016.06.014 | |||
44459272 | 91274 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 491 | 6 | 2 | 7 | 2.6 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | |||
CHEMBL24015 | 91274 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 491 | 6 | 2 | 7 | 2.6 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | |||
22010352 | 117690 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 404 | 10 | 1 | 4 | 5.5 | CC(=O)c1ccc(OCc2ccccc2)cc1OC(CCC(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | |||
CHEMBL3400984 | 117690 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 404 | 10 | 1 | 4 | 5.5 | CC(=O)c1ccc(OCc2ccccc2)cc1OC(CCC(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | |||
10693270 | 60089 | None | 1 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 417 | 7 | 1 | 6 | 4.4 | Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O | 10.1021/jm990378b | |||
CHEMBL172144 | 60089 | None | 1 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 417 | 7 | 1 | 6 | 4.4 | Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O | 10.1021/jm990378b | |||
CHEMBL173792 | 60089 | None | 1 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 417 | 7 | 1 | 6 | 4.4 | Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O | 10.1021/jm990378b | |||
44295257 | 14634 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 538 | 10 | 1 | 9 | 4.8 | COc1cc(F)ccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL1205063 | 14634 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 538 | 10 | 1 | 9 | 4.8 | COc1cc(F)ccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL48458 | 14634 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 538 | 10 | 1 | 9 | 4.8 | COc1cc(F)ccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 | 10.1016/s0960-894x(98)00301-1 | |||
9915095 | 101585 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 535 | 8 | 2 | 8 | 3.4 | CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(C(=O)C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | |||
CHEMBL298212 | 101585 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 535 | 8 | 2 | 8 | 3.4 | CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(C(=O)C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | |||
10864618 | 113385 | None | 0 | Pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 556 | 11 | 1 | 10 | 5.3 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2nccs2)c1 | 10.1021/jm0102304 | |||
CHEMBL331580 | 113385 | None | 0 | Pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 556 | 11 | 1 | 10 | 5.3 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2nccs2)c1 | 10.1021/jm0102304 | |||
10599879 | 101330 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 455 | 5 | 2 | 6 | 4.2 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | |||
CHEMBL296326 | 101330 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 455 | 5 | 2 | 6 | 4.2 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | |||
10233400 | 128753 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL366885 | 128753 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 | 10.1016/s0960-894x(02)01084-3 | |||
10304227 | 130076 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 603 | 10 | 2 | 13 | 4.2 | C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL367686 | 130076 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 603 | 10 | 2 | 13 | 4.2 | C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
10745668 | 206835 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 572 | 10 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCN(C)CC3)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL71787 | 206835 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 572 | 10 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCN(C)CC3)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL137659 | 211205 | None | 0 | Pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O | 10.1021/jm00021a021 | |||||
44302513 | 102773 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 553 | 9 | 3 | 9 | 5.1 | CCCc1c(O)c(C(C)=O)cc(C(C)=O)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
CHEMBL304860 | 102773 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 553 | 9 | 3 | 9 | 5.1 | CCCc1c(O)c(C(C)=O)cc(C(C)=O)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl | 10.1021/jm030528p | |||
10623465 | 206205 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 450 | 6 | 1 | 6 | 3.7 | CCN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 | 10.1021/jm9604585 | |||
CHEMBL6785 | 206205 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 450 | 6 | 1 | 6 | 3.7 | CCN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 | 10.1021/jm9604585 | |||
18617303 | 105851 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1cccc(S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL312685 | 105851 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1cccc(S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/0960-894X(96)00441-6 | |||
15453179 | 207939 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL80538 | 207939 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Br | 10.1016/0960-894X(96)00441-6 | |||
44293866 | 101677 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 461 | 8 | 1 | 6 | 4.8 | CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | |||
CHEMBL298922 | 101677 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 461 | 8 | 1 | 6 | 4.8 | CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | |||
CHEMBL292901 | 213346 | None | 0 | Pig | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00349-X | |||||
10627333 | 60403 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 595 | 11 | 4 | 8 | 4.2 | COC(=O)C1(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2cn(C)c3ccccc23)c2nc(C(=O)O)c(C)o2)CCCCC1 | 10.1021/jm950592+ | |||
CHEMBL174818 | 60403 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 595 | 11 | 4 | 8 | 4.2 | COC(=O)C1(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2cn(C)c3ccccc23)c2nc(C(=O)O)c(C)o2)CCCCC1 | 10.1021/jm950592+ | |||
CHEMBL335416 | 214006 | None | 0 | Pig | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CCCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O | 10.1021/jm00021a021 | |||||
10961510 | 205293 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 7 | 1 | 4 | 6.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm031041j | |||
CHEMBL62425 | 205293 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 7 | 1 | 4 | 6.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm031041j | |||
44371449 | 49392 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c(OC)c1 | 10.1016/s0960-894x(99)00040-2 | |||
CHEMBL156404 | 49392 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c(OC)c1 | 10.1016/s0960-894x(99)00040-2 | |||
44371460 | 49544 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 469 | 5 | 1 | 7 | 4.9 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2oc3ccccc3c21 | 10.1016/s0960-894x(99)00040-2 | |||
CHEMBL156539 | 49544 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 469 | 5 | 1 | 7 | 4.9 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2oc3ccccc3c21 | 10.1016/s0960-894x(99)00040-2 | |||
10961510 | 205293 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 7 | 1 | 4 | 6.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL62425 | 205293 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 7 | 1 | 4 | 6.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
11733232 | 205322 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 460 | 7 | 1 | 6 | 5.2 | CCCOc1cccc2c1C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
CHEMBL62586 | 205322 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 460 | 7 | 1 | 6 | 5.2 | CCCOc1cccc2c1C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
CHEMBL412460 | 215451 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||||
23445317 | 100600 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 456 | 5 | 1 | 7 | 4.1 | Cc1cccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/S0960-894X(97)00367-3 | |||
CHEMBL291404 | 100600 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 456 | 5 | 1 | 7 | 4.1 | Cc1cccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/S0960-894X(97)00367-3 | |||
23445507 | 59780 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 442 | 6 | 1 | 6 | 4.5 | Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00132-7 | |||
CHEMBL172538 | 59780 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 442 | 6 | 1 | 6 | 4.5 | Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00132-7 | |||
44298956 | 198136 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 489 | 9 | 1 | 7 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1OC)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | |||
CHEMBL55666 | 198136 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 489 | 9 | 1 | 7 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1OC)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | |||
10041979 | 99426 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 325 | 6 | 3 | 6 | 1.6 | Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2)c1C | 10.1021/jm00008a013 | |||
CHEMBL282557 | 99426 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 325 | 6 | 3 | 6 | 1.6 | Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2)c1C | 10.1021/jm00008a013 | |||
44266654 | 98125 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 387 | 4 | 1 | 5 | 4.7 | COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccccc1 | 10.1016/0960-894X(96)00170-9 | |||
CHEMBL273258 | 98125 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 387 | 4 | 1 | 5 | 4.7 | COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccccc1 | 10.1016/0960-894X(96)00170-9 | |||
44385576 | 131445 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 539 | 10 | 1 | 10 | 3.4 | C#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL368929 | 131445 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 539 | 10 | 1 | 10 | 3.4 | C#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
11799440 | 209434 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCN(CCC)C(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9132 | 209434 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCN(CCC)C(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
52949197 | 18431 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 555 | 10 | 2 | 7 | 5.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
CHEMBL1271746 | 18431 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 555 | 10 | 2 | 7 | 5.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
10531506 | 12120 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 | 10.1021/jm990171i | |||
CHEMBL1184076 | 12120 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 | 10.1021/jm990171i | |||
CHEMBL331548 | 12120 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 | 10.1021/jm990171i | |||
10650546 | 12124 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 562 | 7 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 | 10.1021/jm990171i | |||
CHEMBL1184091 | 12124 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 562 | 7 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 | 10.1021/jm990171i | |||
CHEMBL332144 | 12124 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 562 | 7 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 | 10.1021/jm990171i | |||
10814743 | 179477 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 484 | 6 | 1 | 9 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C2(Cc3ccc4c(c3)OCO4)OCCO2)c1Cl | 10.1021/jm9700068 | |||
CHEMBL47383 | 179477 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 484 | 6 | 1 | 9 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C2(Cc3ccc4c(c3)OCO4)OCCO2)c1Cl | 10.1021/jm9700068 | |||
10623888 | 163253 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 461 | 8 | 1 | 6 | 3.4 | CCCCS(=O)(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL417971 | 163253 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 461 | 8 | 1 | 6 | 3.4 | CCCCS(=O)(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
10281573 | 59995 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 574 | 9 | 2 | 9 | 4.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccncc2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL173358 | 59995 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 574 | 9 | 2 | 9 | 4.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccncc2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
44385586 | 61682 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 531 | 10 | 1 | 9 | 4.7 | C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL177143 | 61682 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 531 | 10 | 1 | 9 | 4.7 | C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
10645066 | 97247 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 406 | 4 | 1 | 5 | 3.3 | CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Br)cn3)cccc12 | 10.1021/jm9604585 | |||
CHEMBL268339 | 97247 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 406 | 4 | 1 | 5 | 3.3 | CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Br)cn3)cccc12 | 10.1021/jm9604585 | |||
11792960 | 162009 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 361 | 4 | 1 | 4 | 3.8 | CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nc3)cccc12 | 10.1021/jm9604585 | |||
CHEMBL415292 | 162009 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 361 | 4 | 1 | 4 | 3.8 | CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nc3)cccc12 | 10.1021/jm9604585 | |||
10593411 | 205905 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 342 | 4 | 1 | 5 | 2.8 | Cc1cnc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)cn1 | 10.1021/jm9604585 | |||
CHEMBL6583 | 205905 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 342 | 4 | 1 | 5 | 2.8 | Cc1cnc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)cn1 | 10.1021/jm9604585 | |||
127029202 | 137415 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 598 | 11 | 3 | 7 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
CHEMBL3752680 | 137415 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 598 | 11 | 3 | 7 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
10122495 | 30879 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 665 | 12 | 1 | 10 | 6.4 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOCc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL139734 | 30879 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 665 | 12 | 1 | 10 | 6.4 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOCc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
44384177 | 120357 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 6 | 1 | 8 | 4.6 | Cc1noc(NS(=O)(=O)c2ccsc2COc2cc3c(cc2Cl)OCO3)c1Br | 10.1016/S0960-894X(97)00132-7 | |||
CHEMBL352657 | 120357 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 6 | 1 | 8 | 4.6 | Cc1noc(NS(=O)(=O)c2ccsc2COc2cc3c(cc2Cl)OCO3)c1Br | 10.1016/S0960-894X(97)00132-7 | |||
10550033 | 101422 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 419 | 5 | 2 | 9 | 2.9 | Cc1nnc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)s1 | 10.1021/jm9608366 | |||
CHEMBL297048 | 101422 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 419 | 5 | 2 | 9 | 2.9 | Cc1nnc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)s1 | 10.1021/jm9608366 | |||
10626521 | 60095 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 551 | 11 | 4 | 6 | 5.1 | CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)o2)c2ccccc21 | 10.1021/jm950592+ | |||
CHEMBL173833 | 60095 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 551 | 11 | 4 | 6 | 5.1 | CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)o2)c2ccccc21 | 10.1021/jm950592+ | |||
CHEMBL94983 | 218406 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
10671036 | 6659 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c(OC)c1 | 10.1021/jm9606507 | |||
CHEMBL10834 | 6659 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c(OC)c1 | 10.1021/jm9606507 | |||
9932004 | 98230 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 422 | 5 | 1 | 6 | 4.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCC2)cc1 | 10.1021/jm9606507 | |||
CHEMBL273948 | 98230 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 422 | 5 | 1 | 6 | 4.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCC2)cc1 | 10.1021/jm9606507 | |||
10816110 | 108622 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 532 | 13 | 1 | 7 | 4.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OC(C)C(C)O1 | 10.1021/jm980217s | |||
CHEMBL320254 | 108622 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 532 | 13 | 1 | 7 | 4.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OC(C)C(C)O1 | 10.1021/jm980217s | |||
44314619 | 207144 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 631 | 12 | 5 | 4 | 4.5 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL73925 | 207144 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 631 | 12 | 5 | 4 | 4.5 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | |||
10209324 | 14496 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 546 | 8 | 1 | 7 | 6.2 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
CHEMBL12013 | 14496 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 546 | 8 | 1 | 7 | 6.2 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
10740439 | 172851 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 412 | 5 | 2 | 7 | 3.5 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)nc1 | 10.1021/jm9608366 | |||
CHEMBL45087 | 172851 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 412 | 5 | 2 | 7 | 3.5 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)nc1 | 10.1021/jm9608366 | |||
135415889 | 59287 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 587 | 10 | 2 | 13 | 3.6 | C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL170401 | 59287 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 587 | 10 | 2 | 13 | 3.6 | C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
10281943 | 60084 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 589 | 10 | 1 | 10 | 4.9 | COCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL173743 | 60084 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 589 | 10 | 1 | 10 | 4.9 | COCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
10212088 | 96749 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 688 | 12 | 2 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL264035 | 96749 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 688 | 12 | 2 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL2370830 | 212388 | None | 0 | Pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
42630531 | 18495 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 543 | 9 | 2 | 7 | 5.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)C)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | |||
CHEMBL1272299 | 18495 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 543 | 9 | 2 | 7 | 5.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)C)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | |||
10768904 | 12134 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 544 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | |||
CHEMBL1184117 | 12134 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 544 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | |||
CHEMBL333034 | 12134 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 544 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | |||
10385400 | 96260 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 385 | 4 | 1 | 5 | 3.4 | Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCC4=O)cccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL26079 | 96260 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 385 | 4 | 1 | 5 | 3.4 | Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCC4=O)cccc23)c1C | 10.1021/jm00008a013 | |||
10426828 | 98198 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 331 | 4 | 2 | 5 | 3.3 | CNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 | 10.1021/jm00008a013 | |||
CHEMBL27370 | 98198 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 331 | 4 | 2 | 5 | 3.3 | CNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 | 10.1021/jm00008a013 | |||
10361993 | 99620 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 373 | 5 | 1 | 5 | 4.1 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C(C)C)cccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL283652 | 99620 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 373 | 5 | 1 | 5 | 4.1 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C(C)C)cccc23)c1C | 10.1021/jm00008a013 | |||
11103224 | 205110 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 510 | 14 | 1 | 6 | 7.3 | CCCCCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL61406 | 205110 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 510 | 14 | 1 | 6 | 7.3 | CCCCCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
11826847 | 205377 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccccc1OC)O2 | 10.1021/jm010382z | |||
CHEMBL62814 | 205377 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccccc1OC)O2 | 10.1021/jm010382z | |||
10837347 | 8871 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 452 | 8 | 1 | 5 | 3.3 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL109736 | 8871 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 452 | 8 | 1 | 5 | 3.3 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
10298764 | 9856 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 468 | 8 | 1 | 6 | 3.2 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL114084 | 9856 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 468 | 8 | 1 | 6 | 3.2 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL317064 | 213656 | None | 12 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | |||||
44266552 | 4515 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | |||
CHEMBL10218 | 4515 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | |||
CHEMBL337567 | 214057 | None | 0 | Pig | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CSCC[C@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL150719 | 211250 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC | 10.1016/S0960-894X(01)81219-1 | |||||
44371421 | 51450 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 459 | 5 | 1 | 5 | 5.8 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3Cl)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | |||
CHEMBL158204 | 51450 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 459 | 5 | 1 | 5 | 5.8 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3Cl)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | |||
10067008 | 97853 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 359 | 4 | 2 | 5 | 3.2 | CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 | 10.1021/jm00008a013 | |||
CHEMBL27187 | 97853 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 359 | 4 | 2 | 5 | 3.2 | CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 | 10.1021/jm00008a013 | |||
10423091 | 100025 | None | 1 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 267 | 3 | 2 | 5 | 1.7 | Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C | 10.1021/jm00008a013 | |||
CHEMBL286521 | 100025 | None | 1 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 267 | 3 | 2 | 5 | 1.7 | Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C | 10.1021/jm00008a013 | |||
10552007 | 6325 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 462 | 8 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c(OC)c(OC)c3)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | |||
CHEMBL10819 | 6325 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 462 | 8 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c(OC)c(OC)c3)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | |||
10961720 | 205942 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 472 | 6 | 1 | 5 | 6.3 | CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(C(C)C)cc1)O2 | 10.1021/jm010382z | |||
CHEMBL66094 | 205942 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 472 | 6 | 1 | 5 | 6.3 | CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(C(C)C)cc1)O2 | 10.1021/jm010382z | |||
10577405 | 9654 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1C(C)(C)CCCC | 10.1021/jm980217s | |||
CHEMBL112777 | 9654 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1C(C)(C)CCCC | 10.1021/jm980217s | |||
10573912 | 111685 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 415 | 7 | 1 | 5 | 5.5 | O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1Cl | 10.1021/jm970847e | |||
CHEMBL328444 | 111685 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 415 | 7 | 1 | 5 | 5.5 | O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1Cl | 10.1021/jm970847e | |||
10524954 | 209518 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 399 | 6 | 1 | 5 | 4.5 | N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1/C=C(/C(=O)O)c1ccccc1 | 10.1021/jm970847e | |||
CHEMBL91741 | 209518 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 399 | 6 | 1 | 5 | 4.5 | N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1/C=C(/C(=O)O)c1ccccc1 | 10.1021/jm970847e | |||
44298343 | 101848 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 485 | 9 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC#N)c1 | 10.1016/s0960-894x(00)00366-8 | |||
CHEMBL300066 | 101848 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 485 | 9 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC#N)c1 | 10.1016/s0960-894x(00)00366-8 | |||
44298279 | 196591 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 502 | 10 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(C)=O)c1 | 10.1016/s0960-894x(00)00366-8 | |||
CHEMBL54274 | 196591 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 502 | 10 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(C)=O)c1 | 10.1016/s0960-894x(00)00366-8 | |||
155560344 | 176608 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/acs.jmedchem.5b01781 | |||
CHEMBL4568795 | 176608 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/acs.jmedchem.5b01781 | |||
CHEMBL4596821 | 176608 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/acs.jmedchem.5b01781 | |||
155535325 | 172112 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 549 | 10 | 2 | 8 | 5.4 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc(-c2ncccn2)cc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4471434 | 172112 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 549 | 10 | 2 | 8 | 5.4 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc(-c2ncccn2)cc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
44276946 | 106902 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 440 | 5 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc(Cl)c4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144735 | 106902 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 440 | 5 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc(Cl)c4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
44309897 | 207089 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 469 | 5 | 1 | 7 | 4.9 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4c(c3)OCO4)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL73506 | 207089 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 469 | 5 | 1 | 7 | 4.9 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4c(c3)OCO4)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(97)10151-2 | |||
44298988 | 100773 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 459 | 8 | 1 | 6 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | |||
CHEMBL292580 | 100773 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 459 | 8 | 1 | 6 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | |||
10067008 | 97853 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 359 | 4 | 2 | 5 | 3.2 | CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 | 10.1021/jm00004a012 | |||
CHEMBL27187 | 97853 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 359 | 4 | 2 | 5 | 3.2 | CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 | 10.1021/jm00004a012 | |||
10423091 | 100025 | None | 1 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 267 | 3 | 2 | 5 | 1.7 | Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C | 10.1021/jm00004a012 | |||
CHEMBL286521 | 100025 | None | 1 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 267 | 3 | 2 | 5 | 1.7 | Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C | 10.1021/jm00004a012 | |||
44266595 | 4394 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 507 | 6 | 1 | 7 | 6.0 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | |||
CHEMBL10136 | 4394 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 507 | 6 | 1 | 7 | 6.0 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | |||
10337668 | 102192 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 346 | 4 | 2 | 5 | 2.9 | Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C | 10.1021/jm00029a001 | |||
CHEMBL30246 | 102192 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 346 | 4 | 2 | 5 | 2.9 | Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C | 10.1021/jm00029a001 | |||
6662 | 14452 | None | 40 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 309 | 3 | 1 | 6 | 1.6 | CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 | 10.1021/jm00008a013 | |||
CHEMBL1200910 | 14452 | None | 40 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 309 | 3 | 1 | 6 | 1.6 | CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 | 10.1021/jm00008a013 | |||
10337668 | 102192 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 346 | 4 | 2 | 5 | 2.9 | Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL30246 | 102192 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 346 | 4 | 2 | 5 | 2.9 | Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C | 10.1021/jm00008a013 | |||
18617314 | 207690 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 334 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL78734 | 207690 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 334 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL38071 | 214732 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00087a001 | |||||
44213959 | 170471 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 592 | 11 | 3 | 9 | 5.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(=O)Nc2ccccc2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4447655 | 170471 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 592 | 11 | 3 | 9 | 5.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(=O)Nc2ccccc2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
127026027 | 137360 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
CHEMBL3752145 | 137360 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
CHEMBL1791280 | 211379 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00152-J | |||||
10816667 | 11448 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 558 | 9 | 2 | 6 | 5.6 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | |||
CHEMBL1180341 | 11448 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 558 | 9 | 2 | 6 | 5.6 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | |||
CHEMBL122933 | 11448 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 558 | 9 | 2 | 6 | 5.6 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | |||
9853680 | 98701 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 771 | 17 | 2 | 14 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL277275 | 98701 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 771 | 17 | 2 | 14 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
10576378 | 101177 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 471 | 6 | 2 | 7 | 3.9 | COc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br | 10.1021/jm9608366 | |||
CHEMBL295207 | 101177 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 471 | 6 | 2 | 7 | 3.9 | COc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br | 10.1021/jm9608366 | |||
CHEMBL170229 | 211301 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)N1CCCCCC1)C(=O)O | 10.1016/0960-894X(95)00144-I | |||||
23445219 | 112538 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 428 | 5 | 1 | 6 | 4.3 | COc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL329861 | 112538 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 428 | 5 | 1 | 6 | 4.3 | COc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/S0960-894X(96)00496-9 | |||
44386163 | 60400 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 577 | 14 | 2 | 10 | 3.4 | CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL174781 | 60400 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 577 | 14 | 2 | 10 | 3.4 | CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
23445537 | 61165 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 514 | 8 | 1 | 8 | 4.9 | CCCc1cc2c(cc1OCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00132-7 | |||
CHEMBL176538 | 61165 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 514 | 8 | 1 | 8 | 4.9 | CCCc1cc2c(cc1OCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00132-7 | |||
10766067 | 9740 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 452 | 8 | 1 | 5 | 3.3 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL113379 | 9740 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 452 | 8 | 1 | 5 | 3.3 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
127035069 | 136486 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 663 | 11 | 2 | 8 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
CHEMBL3735300 | 136486 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 663 | 11 | 2 | 8 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
10792785 | 166819 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 551 | 10 | 3 | 6 | 5.0 | CCOC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C | 10.1021/jm950592+ | |||
CHEMBL428298 | 166819 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 551 | 10 | 3 | 6 | 5.0 | CCOC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C | 10.1021/jm950592+ | |||
9831527 | 129550 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 698 | 14 | 2 | 12 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL367274 | 129550 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 698 | 14 | 2 | 12 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | |||
10189776 | 60077 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 651 | 11 | 1 | 10 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL173689 | 60077 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 651 | 11 | 1 | 10 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
10743478 | 109324 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 484 | 12 | 1 | 4 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm031041j | |||
CHEMBL321852 | 109324 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 484 | 12 | 1 | 4 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm031041j | |||
10504389 | 130742 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 466 | 7 | 1 | 5 | 5.5 | COc1ccc(C(=O)/C(Cc2cccc3ccccc23)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm031041j | |||
CHEMBL368270 | 130742 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 466 | 7 | 1 | 5 | 5.5 | COc1ccc(C(=O)/C(Cc2cccc3ccccc23)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm031041j | |||
10505209 | 9319 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 490 | 6 | 1 | 9 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
CHEMBL11106 | 9319 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 490 | 6 | 1 | 9 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
10742841 | 97402 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 466 | 5 | 1 | 6 | 5.0 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3ccccc3c2)cc1 | 10.1021/jm9606507 | |||
CHEMBL269453 | 97402 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 466 | 5 | 1 | 6 | 5.0 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3ccccc3c2)cc1 | 10.1021/jm9606507 | |||
44314645 | 172775 | None | 0 | Pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 601 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC1CC1)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL449962 | 172775 | None | 0 | Pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 601 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC1CC1)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
10743478 | 109324 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 484 | 12 | 1 | 4 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL321852 | 109324 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 484 | 12 | 1 | 4 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
10166561 | 10066 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 562 | 9 | 2 | 8 | 5.4 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
CHEMBL11528 | 10066 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 562 | 9 | 2 | 8 | 5.4 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
44214320 | 85384 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 510 | 6 | 1 | 7 | 4.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(F)ccc12 | 10.1007/s00044-004-0021-y | |||
CHEMBL2261364 | 85384 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 510 | 6 | 1 | 7 | 4.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(F)ccc12 | 10.1007/s00044-004-0021-y | |||
10240093 | 81718 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 603 | 12 | 1 | 12 | 3.5 | CCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | |||
CHEMBL2163713 | 81718 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 603 | 12 | 1 | 12 | 3.5 | CCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | |||
71458721 | 81732 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 642 | 14 | 2 | 10 | 4.6 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(C2CC2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163726 | 81732 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 642 | 14 | 2 | 10 | 4.6 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(C2CC2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
10812894 | 120340 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 437 | 7 | 1 | 6 | 4.7 | N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm990378b | |||
CHEMBL352536 | 120340 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 437 | 7 | 1 | 6 | 4.7 | N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm990378b | |||
17869371 | 14795 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 478 | 8 | 1 | 7 | 4.8 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL1206716 | 14795 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 478 | 8 | 1 | 7 | 4.8 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL299521 | 14795 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 478 | 8 | 1 | 7 | 4.8 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | |||
44293417 | 187442 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 563 | 11 | 2 | 8 | 4.9 | CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(C)(C)C(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | |||
CHEMBL49312 | 187442 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 563 | 11 | 2 | 8 | 4.9 | CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(C)(C)C(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | |||
443289 | 711 | None | 39 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | -2 | 3 | ChEMBL | None | None | None | None | 10.1021/jm9707131 | |||||
997 | 711 | None | 39 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | -2 | 3 | ChEMBL | None | None | None | None | 10.1021/jm9707131 | |||||
CHEMBL314691 | 711 | None | 39 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | -2 | 3 | ChEMBL | None | None | None | None | 10.1021/jm9707131 | |||||
DB12054 | 711 | None | 39 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | -2 | 3 | ChEMBL | None | None | None | None | 10.1021/jm9707131 | |||||
10814746 | 181700 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 484 | 6 | 1 | 8 | 3.8 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | |||
CHEMBL47706 | 181700 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 484 | 6 | 1 | 8 | 3.8 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | |||
10122675 | 98525 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 682 | 12 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL275897 | 98525 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 682 | 12 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL1791271 | 211375 | None | 1 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00152-J | |||||
9831249 | 59717 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 2 | ChEMBL | 672 | 14 | 2 | 10 | 6.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL172297 | 59717 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 2 | ChEMBL | 672 | 14 | 2 | 10 | 6.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
44311283 | 102388 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 649 | 11 | 2 | 10 | 6.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL303649 | 102388 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 649 | 11 | 2 | 10 | 6.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
44320590 | 106617 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 556 | 10 | 2 | 9 | 4.8 | COc1ccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL314206 | 106617 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 556 | 10 | 2 | 9 | 4.8 | COc1ccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL1788127 | 213575 | None | 5 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
CHEMBL313760 | 213575 | None | 5 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
44382933 | 165194 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 541 | 12 | 4 | 5 | 3.2 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCCCC(=O)O | 10.1016/0960-894X(95)00144-I | |||
CHEMBL422720 | 165194 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 541 | 12 | 4 | 5 | 3.2 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCCCC(=O)O | 10.1016/0960-894X(95)00144-I | |||
CHEMBL330144 | 213786 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C | 10.1021/jm00015a003 | |||||
22616257 | 207472 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 272 | 3 | 1 | 4 | 2.4 | Cc1noc(NS(=O)(=O)c2ccccc2)c1Cl | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL76860 | 207472 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 272 | 3 | 1 | 4 | 2.4 | Cc1noc(NS(=O)(=O)c2ccccc2)c1Cl | 10.1016/0960-894X(96)00441-6 | |||
44317109 | 104948 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 472 | 3 | 1 | 4 | 4.1 | Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL311216 | 104948 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 472 | 3 | 1 | 4 | 4.1 | Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1Br | 10.1016/0960-894X(96)00441-6 | |||
18617327 | 207714 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1ccccc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL78929 | 207714 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1ccccc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | |||
44276969 | 106895 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 7 | 1 | 5 | 4.8 | COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144607 | 106895 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 7 | 1 | 5 | 4.8 | COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
9961131 | 132225 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 2 | ChEMBL | 650 | 15 | 2 | 12 | 3.1 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL369676 | 132225 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 2 | ChEMBL | 650 | 15 | 2 | 12 | 3.1 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL342617 | 214135 | None | 0 | Pig | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL407639 | 215132 | None | 0 | Pig | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CS(=O)(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
10381121 | 96286 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 317 | 3 | 2 | 5 | 2.8 | Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL26090 | 96286 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 317 | 3 | 2 | 5 | 2.8 | Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C | 10.1021/jm00008a013 | |||
9974856 | 99407 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C | 10.1021/jm00008a013 | |||
CHEMBL282401 | 99407 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C | 10.1021/jm00008a013 | |||
CHEMBL1790499 | 211351 | None | 0 | Pig | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | CC[C@@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC1=O | 10.1021/jm00089a028 | |||||
CHEMBL327350 | 213749 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
18617355 | 207412 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL76438 | 207412 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL432683 | 216095 | None | 0 | Pig | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00087a001 | |||||
10618969 | 209801 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 367 | 7 | 1 | 5 | 4.8 | O=[N+]([O-])c1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1 | 10.1021/jm970847e | |||
CHEMBL93596 | 209801 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 367 | 7 | 1 | 5 | 4.8 | O=[N+]([O-])c1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1 | 10.1021/jm970847e | |||
127034901 | 136565 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 670 | 12 | 2 | 9 | 5.5 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
CHEMBL3736037 | 136565 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 670 | 12 | 2 | 9 | 5.5 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
44298382 | 197508 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 502 | 11 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCC=O)c1 | 10.1016/s0960-894x(00)00366-8 | |||
CHEMBL54998 | 197508 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 502 | 11 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCC=O)c1 | 10.1016/s0960-894x(00)00366-8 | |||
9974856 | 99407 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C | 10.1021/jm00004a012 | |||
CHEMBL282401 | 99407 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C | 10.1021/jm00004a012 | |||
CHEMBL343379 | 214158 | None | 0 | Pig | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL343379 | 214158 | None | 0 | Pig | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL315780 | 213651 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c1csc2ccccc12)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
10334781 | 96063 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 297 | 4 | 1 | 6 | 2.0 | Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1C | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL25970 | 96063 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 297 | 4 | 1 | 6 | 2.0 | Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1C | 10.1016/0960-894X(96)00441-6 | |||
18617299 | 207732 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 320 | 3 | 1 | 4 | 3.4 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1C | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL79054 | 207732 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 320 | 3 | 1 | 4 | 3.4 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1C | 10.1016/0960-894X(96)00441-6 | |||
127028930 | 137391 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 570 | 9 | 3 | 7 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
CHEMBL3752444 | 137391 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 570 | 9 | 3 | 7 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
10769025 | 60290 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 550 | 10 | 5 | 5 | 4.6 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL174171 | 60290 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 550 | 10 | 5 | 5 | 4.6 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O | 10.1021/jm950592+ | |||
44384656 | 130163 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 468 | 5 | 1 | 7 | 4.5 | Cc1noc(NS(=O)(=O)c2ccsc2/C=C/c2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | |||
CHEMBL367763 | 130163 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 468 | 5 | 1 | 7 | 4.5 | Cc1noc(NS(=O)(=O)c2ccsc2/C=C/c2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | |||
10577111 | 209355 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 493 | 7 | 1 | 6 | 4.0 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)COc2ccc(F)cc2)cc1 | 10.1021/jm9505369 | |||
CHEMBL9084 | 209355 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 493 | 7 | 1 | 6 | 4.0 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)COc2ccc(F)cc2)cc1 | 10.1021/jm9505369 | |||
10723203 | 11454 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 678 | 14 | 2 | 7 | 6.8 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | |||
CHEMBL1180350 | 11454 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 678 | 14 | 2 | 7 | 6.8 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | |||
CHEMBL123206 | 11454 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 678 | 14 | 2 | 7 | 6.8 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | |||
44291584 | 101288 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 501 | 8 | 3 | 9 | 3.5 | COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 | 10.1021/jm9608366 | |||
CHEMBL296074 | 101288 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 501 | 8 | 3 | 9 | 3.5 | COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 | 10.1021/jm9608366 | |||
10625875 | 129716 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 523 | 9 | 4 | 5 | 4.6 | Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O | 10.1021/jm950591h | |||
CHEMBL367313 | 129716 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 523 | 9 | 4 | 5 | 4.6 | Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O | 10.1021/jm950591h | |||
10625875 | 129716 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 523 | 9 | 4 | 5 | 4.6 | Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL367313 | 129716 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 523 | 9 | 4 | 5 | 4.6 | Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O | 10.1021/jm950592+ | |||
22998447 | 209133 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 414 | 5 | 1 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2sccc2Oc2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL89457 | 209133 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 414 | 5 | 1 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2sccc2Oc2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
10381121 | 96286 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 317 | 3 | 2 | 5 | 2.8 | Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C | 10.1021/jm00004a012 | |||
CHEMBL26090 | 96286 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 317 | 3 | 2 | 5 | 2.8 | Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C | 10.1021/jm00004a012 | |||
10718688 | 183732 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 457 | 5 | 3 | 7 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(O)c2)c1Br | 10.1021/jm9608366 | |||
CHEMBL48024 | 183732 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 457 | 5 | 3 | 7 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(O)c2)c1Br | 10.1021/jm9608366 | |||
23445325 | 205845 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 397 | 5 | 2 | 6 | 3.8 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Cl | 10.1016/S0960-894X(97)00367-3 | |||
CHEMBL65407 | 205845 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 397 | 5 | 2 | 6 | 3.8 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Cl | 10.1016/S0960-894X(97)00367-3 | |||
10961546 | 96812 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm031041j | |||
CHEMBL264543 | 96812 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm031041j | |||
122272 | 97150 | None | 32 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL267458 | 97150 | None | 32 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00008a013 | |||
10961546 | 96812 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL264543 | 96812 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
44314751 | 161449 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 603 | 13 | 5 | 4 | 5.0 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL412602 | 161449 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 603 | 13 | 5 | 4 | 5.0 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
10602620 | 16598 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 544 | 10 | 2 | 6 | 5.4 | CCCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | |||
CHEMBL123997 | 16598 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 544 | 10 | 2 | 6 | 5.4 | CCCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | |||
10529868 | 164286 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 516 | 8 | 2 | 6 | 4.8 | CCc1cccc(C)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | |||
CHEMBL421073 | 164286 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 516 | 8 | 2 | 6 | 4.8 | CCc1cccc(C)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | |||
127035410 | 136472 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 557 | 8 | 1 | 8 | 5.7 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
CHEMBL3735155 | 136472 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 557 | 8 | 1 | 8 | 5.7 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
44320474 | 107124 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 440 | 8 | 1 | 5 | 5.7 | CCC(CC)Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL315752 | 107124 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 440 | 8 | 1 | 5 | 5.7 | CCC(CC)Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | |||
10575845 | 11233 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 457 | 7 | 2 | 8 | 3.8 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 | 10.1021/jm9608366 | |||
CHEMBL1178807 | 11233 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 457 | 7 | 2 | 8 | 3.8 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 | 10.1021/jm9608366 | |||
CHEMBL43788 | 11233 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 457 | 7 | 2 | 8 | 3.8 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 | 10.1021/jm9608366 | |||
10811595 | 98821 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 411 | 5 | 2 | 6 | 4.1 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9608366 | |||
10811595 | 98821 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 411 | 5 | 2 | 6 | 4.1 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9700068 | |||
CHEMBL278114 | 98821 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 411 | 5 | 2 | 6 | 4.1 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9608366 | |||
CHEMBL278114 | 98821 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 411 | 5 | 2 | 6 | 4.1 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9700068 | |||
CHEMBL328942 | 213775 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | |||||
10360201 | 95739 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1onc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00004a012 | |||
CHEMBL25816 | 95739 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1onc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00004a012 | |||
122272 | 97150 | None | 32 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00004a012 | |||
CHEMBL267458 | 97150 | None | 32 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00004a012 | |||
44283349 | 100380 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 603 | 13 | 5 | 4 | 5.0 | CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | |||
CHEMBL289410 | 100380 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 603 | 13 | 5 | 4 | 5.0 | CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | |||
44334053 | 4553 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 465 | 5 | 1 | 5 | 5.5 | COc1ccc([C@@H]2c3nc(-c4ccccc4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL102411 | 4553 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 465 | 5 | 1 | 5 | 5.5 | COc1ccc([C@@H]2c3nc(-c4ccccc4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
10811595 | 98821 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 411 | 5 | 2 | 6 | 4.1 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm000349x | |||
CHEMBL278114 | 98821 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 411 | 5 | 2 | 6 | 4.1 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm000349x | |||
CHEMBL336563 | 214043 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL347948 | 214173 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81219-1 | |||||
11072080 | 12108 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 600 | 11 | 1 | 9 | 6.4 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccc3ccccc3n2)c1 | 10.1021/jm0102304 | |||
CHEMBL1183970 | 12108 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 600 | 11 | 1 | 9 | 6.4 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccc3ccccc3n2)c1 | 10.1021/jm0102304 | |||
CHEMBL326160 | 12108 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 600 | 11 | 1 | 9 | 6.4 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccc3ccccc3n2)c1 | 10.1021/jm0102304 | |||
155562688 | 175284 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 554 | 13 | 2 | 10 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4570529 | 175284 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 554 | 13 | 2 | 10 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | |||
22616258 | 105462 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 372 | 5 | 1 | 4 | 3.8 | CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL311781 | 105462 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 372 | 5 | 1 | 4 | 3.8 | CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | |||
10740943 | 205864 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 422 | 5 | 2 | 6 | 3.2 | CNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 | 10.1021/jm9604585 | |||
CHEMBL6555 | 205864 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 422 | 5 | 2 | 6 | 3.2 | CNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 | 10.1021/jm9604585 | |||
CHEMBL67074 | 206072 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 646 | 8 | 2 | 13 | 5.8 | COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC(=O)C2=C(C)N=C(C)/C(=C(/O)OC)[C@@H]2c2cccc([N+](=O)[O-])c2)[C@@H]1c1cccc([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81025-8 | |||
122272 | 97150 | None | 32 | Human | Binding | pIC50 | = | 6.8 | 6.8 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00029a001 | |||
CHEMBL267458 | 97150 | None | 32 | Human | Binding | pIC50 | = | 6.8 | 6.8 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm00029a001 | |||
10095393 | 97611 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 452 | 5 | 3 | 5 | 5.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N/C(S)=N/c4ccccc4)cccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL27063 | 97611 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 452 | 5 | 3 | 5 | 5.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N/C(S)=N/c4ccccc4)cccc23)c1C | 10.1021/jm00008a013 | |||
10576863 | 8290 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 484 | 5 | 1 | 6 | 5.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)c(Cl)c2)cc1 | 10.1021/jm9606507 | |||
CHEMBL10926 | 8290 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 484 | 5 | 1 | 6 | 5.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)c(Cl)c2)cc1 | 10.1021/jm9606507 | |||
44279338 | 106750 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 487 | 11 | 6 | 4 | 2.3 | CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O | 10.1016/0960-894X(95)00221-E | |||
CHEMBL31436 | 106750 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 487 | 11 | 6 | 4 | 2.3 | CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O | 10.1016/0960-894X(95)00221-E | |||
44279309 | 161911 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 412 | 3 | 2 | 3 | 4.5 | Cc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 | 10.1016/0960-894X(95)00230-Q | |||
CHEMBL414408 | 161911 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 412 | 3 | 2 | 3 | 4.5 | Cc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 | 10.1016/0960-894X(95)00230-Q | |||
10641986 | 209693 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 356 | 6 | 1 | 4 | 4.2 | N#Cc1ccc(OCc2cccnc2)cc1/C=C(/C(=O)O)c1ccccc1 | 10.1021/jm970847e | |||
CHEMBL92842 | 209693 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 356 | 6 | 1 | 4 | 4.2 | N#Cc1ccc(OCc2cccnc2)cc1/C=C(/C(=O)O)c1ccccc1 | 10.1021/jm970847e | |||
44266646 | 98618 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 475 | 6 | 1 | 8 | 4.5 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL276638 | 98618 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 475 | 6 | 1 | 8 | 4.5 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/s0960-894x(97)10151-2 | |||
10087191 | 101892 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 317 | 3 | 2 | 5 | 2.8 | Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C | 10.1021/jm00004a012 | |||
CHEMBL30039 | 101892 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 317 | 3 | 2 | 5 | 2.8 | Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C | 10.1021/jm00004a012 | |||
CHEMBL424227 | 215783 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00349-X | |||||
44334084 | 109709 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 461 | 7 | 2 | 6 | 3.8 | COc1ccc([C@@H]2c3nc(CCC(=O)O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL322434 | 109709 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 461 | 7 | 2 | 6 | 3.8 | COc1ccc([C@@H]2c3nc(CCC(=O)O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
122272 | 97150 | None | 32 | Human | Binding | pIC50 | = | 6.8 | 6.8 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm030480f | |||
CHEMBL267458 | 97150 | None | 32 | Human | Binding | pIC50 | = | 6.8 | 6.8 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1021/jm030480f | |||
44266646 | 98618 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 475 | 6 | 1 | 8 | 4.5 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1021/jm0300429 | |||
CHEMBL276638 | 98618 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 475 | 6 | 1 | 8 | 4.5 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1021/jm0300429 | |||
CHEMBL137671 | 211206 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL335128 | 214004 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
44371429 | 48914 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 455 | 6 | 1 | 6 | 5.2 | COc1cccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 | 10.1016/s0960-894x(99)00040-2 | |||
CHEMBL155973 | 48914 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 455 | 6 | 1 | 6 | 5.2 | COc1cccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 | 10.1016/s0960-894x(99)00040-2 | |||
44316993 | 207397 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 286 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1C | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL76360 | 207397 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 286 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1C | 10.1016/0960-894X(96)00441-6 | |||
10983585 | 173378 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 473 | 9 | 2 | 8 | 3.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO | 10.1021/acs.jmedchem.0c01093 | |||
CHEMBL4525321 | 173378 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 473 | 9 | 2 | 8 | 3.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO | 10.1021/acs.jmedchem.0c01093 | |||
10650477 | 114313 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 558 | 10 | 2 | 6 | 5.8 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC(C)C)cc1 | 10.1021/jm990170q | |||
CHEMBL333009 | 114313 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 558 | 10 | 2 | 6 | 5.8 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC(C)C)cc1 | 10.1021/jm990170q | |||
44298356 | 197229 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 503 | 10 | 2 | 8 | 5.7 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC/C=N/O)c1 | 10.1016/s0960-894x(00)00366-8 | |||
CHEMBL54703 | 197229 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 503 | 10 | 2 | 8 | 5.7 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC/C=N/O)c1 | 10.1016/s0960-894x(00)00366-8 | |||
10983585 | 173378 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 473 | 9 | 2 | 8 | 3.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4525321 | 173378 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 473 | 9 | 2 | 8 | 3.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
66875612 | 175376 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 495 | 10 | 2 | 10 | 2.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4572634 | 175376 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 495 | 10 | 2 | 10 | 2.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
10693981 | 59569 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 431 | 7 | 1 | 6 | 4.4 | Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCCO3)ccc1C#N)C(=O)O | 10.1021/jm990378b | |||
CHEMBL171702 | 59569 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 431 | 7 | 1 | 6 | 4.4 | Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCCO3)ccc1C#N)C(=O)O | 10.1021/jm990378b | |||
15340612 | 106888 | None | 1 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144599 | 106888 | None | 1 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
10744921 | 60073 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 536 | 10 | 5 | 4 | 4.6 | CCc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O | 10.1021/jm950591h | |||
CHEMBL173666 | 60073 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 536 | 10 | 5 | 4 | 4.6 | CCc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O | 10.1021/jm950591h | |||
44299023 | 198954 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 457 | 6 | 1 | 6 | 4.7 | CCc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | |||
CHEMBL56343 | 198954 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 457 | 6 | 1 | 6 | 4.7 | CCc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | |||
44332577 | 4708 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 341 | 3 | 0 | 4 | 4.4 | O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
CHEMBL103484 | 4708 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 341 | 3 | 0 | 4 | 4.4 | O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 | 10.1016/S0960-894X(96)00551-3 | |||
44266540 | 4907 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 447 | 6 | 1 | 7 | 4.8 | COc1ccc2c(c1)c(-c1ccc(OC)c(OC)c1)c(C(=O)O)n2-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | |||
CHEMBL10457 | 4907 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 447 | 6 | 1 | 7 | 4.8 | COc1ccc2c(c1)c(-c1ccc(OC)c(OC)c1)c(C(=O)O)n2-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | |||
44266549 | 162461 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 415 | 4 | 1 | 6 | 4.5 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | |||
CHEMBL416518 | 162461 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 415 | 4 | 1 | 6 | 4.5 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | |||
19432649 | 206946 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 487 | 9 | 2 | 8 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCO | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL72473 | 206946 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 487 | 9 | 2 | 8 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCO | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL342215 | 214122 | None | 0 | Pig | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2cn(C(=O)OC(C)(C)C)c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
44279349 | 168250 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 448 | 3 | 2 | 3 | 5.3 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cccc4ccccc34)cc21 | 10.1016/0960-894X(95)00230-Q | |||
CHEMBL433039 | 168250 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 448 | 3 | 2 | 3 | 5.3 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cccc4ccccc34)cc21 | 10.1016/0960-894X(95)00230-Q | |||
CHEMBL336087 | 214036 | None | 0 | Pig | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00021a021 | |||||
44386537 | 127877 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 532 | 10 | 4 | 7 | 4.2 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccnc2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL366391 | 127877 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 532 | 10 | 4 | 7 | 4.2 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccnc2)nc1C(=O)O | 10.1021/jm950592+ | |||
10188517 | 61786 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 582 | 9 | 2 | 10 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL177203 | 61786 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 582 | 9 | 2 | 10 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
10122442 | 130765 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 660 | 14 | 2 | 11 | 5.6 | CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL368383 | 130765 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 660 | 14 | 2 | 11 | 5.6 | CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
10832511 | 205862 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 3.2 | CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Cl)cn3)cccc12 | 10.1021/jm9604585 | |||
CHEMBL6553 | 205862 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 3.2 | CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Cl)cn3)cccc12 | 10.1021/jm9604585 | |||
104865 | 706 | None | 60 | Human | Binding | pIC50 | = | 5.8 | 5.8 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | |||
104865.0 | 706 | None | 60 | Human | Binding | pIC50 | = | 5.8 | 5.8 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | |||
3494 | 706 | None | 60 | Human | Binding | pIC50 | = | 5.8 | 5.8 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | |||
392 | 706 | None | 60 | Human | Binding | pIC50 | = | 5.8 | 5.8 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | |||
CHEMBL957 | 706 | None | 60 | Human | Binding | pIC50 | = | 5.8 | 5.8 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | |||
DB00559 | 706 | None | 60 | Human | Binding | pIC50 | = | 5.8 | 5.8 | 1 | 4 | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | |||
10569313 | 97256 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 342 | 4 | 1 | 5 | 2.8 | Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 | 10.1021/jm9604585 | |||
CHEMBL268387 | 97256 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 342 | 4 | 1 | 5 | 2.8 | Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 | 10.1021/jm9604585 | |||
5018984 | 205588 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 405 | 4 | 1 | 4 | 3.9 | CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)cn3)cccc12 | 10.1021/jm9604585 | |||
CHEMBL6411 | 205588 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 405 | 4 | 1 | 4 | 3.9 | CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)cn3)cccc12 | 10.1021/jm9604585 | |||
10690058 | 205655 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 3.2 | CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Cl)cn3)cccc12 | 10.1021/jm9604585 | |||
CHEMBL6433 | 205655 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 3.2 | CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Cl)cn3)cccc12 | 10.1021/jm9604585 | |||
5017966 | 205724 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 341 | 4 | 1 | 4 | 3.4 | Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nc1 | 10.1021/jm9604585 | |||
CHEMBL6463 | 205724 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 341 | 4 | 1 | 4 | 3.4 | Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nc1 | 10.1021/jm9604585 | |||
23445285 | 112440 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 454 | 7 | 1 | 5 | 5.6 | CCCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL329560 | 112440 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 454 | 7 | 1 | 5 | 5.6 | CCCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | |||
10250826 | 99159 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 407 | 5 | 1 | 5 | 4.7 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1-c1ccccc1 | 10.1021/jm00008a013 | |||
CHEMBL280823 | 99159 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 407 | 5 | 1 | 5 | 4.7 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1-c1ccccc1 | 10.1021/jm00008a013 | |||
9980084 | 102188 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 429 | 10 | 1 | 5 | 5.7 | CCCCN(CCCC)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 | 10.1021/jm00008a013 | |||
CHEMBL30245 | 102188 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 429 | 10 | 1 | 5 | 5.7 | CCCCN(CCCC)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 | 10.1021/jm00008a013 | |||
9852624 | 128749 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 656 | 14 | 2 | 11 | 4.5 | CCS(=O)(=O)NCCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL366872 | 128749 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 656 | 14 | 2 | 11 | 4.5 | CCS(=O)(=O)NCCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
10744040 | 113633 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 | 10.1021/jm031041j | |||
CHEMBL332231 | 113633 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 | 10.1021/jm031041j | |||
10815726 | 11452 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 516 | 8 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 | 10.1021/jm990171i | |||
CHEMBL1180348 | 11452 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 516 | 8 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 | 10.1021/jm990171i | |||
CHEMBL123146 | 11452 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 516 | 8 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 | 10.1021/jm990171i | |||
10671649 | 98619 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 460 | 5 | 1 | 8 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
CHEMBL276639 | 98619 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 460 | 5 | 1 | 8 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | |||
10299975 | 110310 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 488 | 14 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(C)CC | 10.1021/jm980217s | |||
CHEMBL323791 | 110310 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 488 | 14 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(C)CC | 10.1021/jm980217s | |||
10816152 | 16340 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 534 | 9 | 2 | 8 | 3.9 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(OC)cccc2OC)cc1 | 10.1021/jm990170q | |||
CHEMBL122832 | 16340 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 534 | 9 | 2 | 8 | 3.9 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(OC)cccc2OC)cc1 | 10.1021/jm990170q | |||
10744040 | 113633 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 | 10.1021/jm990170q | |||
CHEMBL332231 | 113633 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 | 10.1021/jm990170q | |||
10552344 | 59233 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 471 | 7 | 1 | 6 | 5.1 | N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1C(F)(F)F | 10.1021/jm990378b | |||
CHEMBL170202 | 59233 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 471 | 7 | 1 | 6 | 5.1 | N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1C(F)(F)F | 10.1021/jm990378b | |||
44295156 | 14633 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL1205062 | 14633 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL48411 | 14633 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 | 10.1016/s0960-894x(98)00301-1 | |||
10231591 | 131428 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 569 | 10 | 2 | 11 | 2.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL368828 | 131428 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 569 | 10 | 2 | 11 | 2.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
10338502 | 119539 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 359 | 4 | 2 | 5 | 3.2 | CC(=O)Nc1cccc2c(S(=O)(=O)Nc3noc(C)c3C)cccc12 | 10.1021/jm00004a012 | |||
CHEMBL345247 | 119539 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 359 | 4 | 2 | 5 | 3.2 | CC(=O)Nc1cccc2c(S(=O)(=O)Nc3noc(C)c3C)cccc12 | 10.1021/jm00004a012 | |||
44386370 | 60435 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 531 | 10 | 4 | 6 | 4.8 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL175066 | 60435 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 531 | 10 | 4 | 6 | 4.8 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O | 10.1021/jm950592+ | |||
15453177 | 207979 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL80857 | 207979 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
10601795 | 97025 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 510 | 10 | 1 | 6 | 4.4 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CC(C)C)CC(C)C)cc1 | 10.1021/jm9505369 | |||
CHEMBL266354 | 97025 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 510 | 10 | 1 | 6 | 4.4 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CC(C)C)CC(C)C)cc1 | 10.1021/jm9505369 | |||
44265869 | 97315 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 466 | 7 | 2 | 6 | 3.3 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2CCCC2)cc1 | 10.1021/jm9505369 | |||
CHEMBL268864 | 97315 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 466 | 7 | 2 | 6 | 3.3 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2CCCC2)cc1 | 10.1021/jm9505369 | |||
44278003 | 99322 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 449 | 8 | 1 | 6 | 5.6 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL28188 | 99322 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 449 | 8 | 1 | 6 | 5.6 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | |||
18617302 | 104472 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 334 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccccc2F)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL310361 | 104472 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 334 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccccc2F)c1Br | 10.1016/0960-894X(96)00441-6 | |||
15453180 | 105281 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 348 | 4 | 1 | 4 | 4.1 | Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Cl | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL311510 | 105281 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 348 | 4 | 1 | 4 | 4.1 | Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Cl | 10.1016/0960-894X(96)00441-6 | |||
10951244 | 205411 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 504 | 9 | 1 | 7 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cc(OC)ccc1OC)O2 | 10.1021/jm010382z | |||
CHEMBL62962 | 205411 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 504 | 9 | 1 | 7 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cc(OC)ccc1OC)O2 | 10.1021/jm010382z | |||
11100307 | 205659 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 354 | 5 | 1 | 5 | 3.8 | CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | |||
CHEMBL64340 | 205659 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 354 | 5 | 1 | 5 | 3.8 | CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | |||
44314461 | 207237 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 605 | 13 | 5 | 4 | 3.9 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCC1)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL74837 | 207237 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 605 | 13 | 5 | 4 | 3.9 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCC1)C(=O)O | 10.1021/jm9600914 | |||
10767778 | 16409 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)cc(C)c2)cc1 | 10.1021/jm990170q | |||
CHEMBL123077 | 16409 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)cc(C)c2)cc1 | 10.1021/jm990170q | |||
44295114 | 14886 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 556 | 11 | 1 | 9 | 5.3 | COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL1207717 | 14886 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 556 | 11 | 1 | 9 | 5.3 | COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL433090 | 14886 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 556 | 11 | 1 | 9 | 5.3 | COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | |||
122044 | 10175 | None | 42 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 473 | 9 | 2 | 8 | 3.7 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 | 10.1021/jm0102304 | |||
CHEMBL115951 | 10175 | None | 42 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 473 | 9 | 2 | 8 | 3.7 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 | 10.1021/jm0102304 | |||
44309814 | 103061 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 487 | 8 | 1 | 7 | 6.2 | CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1cc2nsnc2cc1C | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL306863 | 103061 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 487 | 8 | 1 | 7 | 6.2 | CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1cc2nsnc2cc1C | 10.1016/s0960-894x(97)10151-2 | |||
44327380 | 111667 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 457 | 6 | 1 | 9 | 1.4 | COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C)ccc2=O)cc1 | 10.1016/S0960-894X(96)00617-8 | |||
CHEMBL328311 | 111667 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 457 | 6 | 1 | 9 | 1.4 | COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C)ccc2=O)cc1 | 10.1016/S0960-894X(96)00617-8 | |||
CHEMBL136634 | 211199 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL337031 | 214049 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL342840 | 214153 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
10926281 | 102813 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 354 | 4 | 1 | 5 | 3.8 | CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 | 10.1021/jm031041j | |||
CHEMBL305117 | 102813 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 354 | 4 | 1 | 5 | 3.8 | CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 | 10.1021/jm031041j | |||
10926281 | 102813 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 354 | 4 | 1 | 5 | 3.8 | CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
CHEMBL305117 | 102813 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 354 | 4 | 1 | 5 | 3.8 | CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
11026419 | 205640 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 432 | 5 | 1 | 6 | 4.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3c(OC)cccc32)cc1 | 10.1021/jm010382z | |||
CHEMBL64266 | 205640 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 432 | 5 | 1 | 6 | 4.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3c(OC)cccc32)cc1 | 10.1021/jm010382z | |||
44368819 | 168995 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1637 | 31 | 19 | 20 | 1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||
77282140 | 168995 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1637 | 31 | 19 | 20 | 1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||
CHEMBL438380 | 168995 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1637 | 31 | 19 | 20 | 1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||
44270524 | 98260 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 682 | 13 | 1 | 9 | 6.9 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccccc1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | |||
CHEMBL274243 | 98260 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 682 | 13 | 1 | 9 | 6.9 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccccc1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | |||
44267002 | 98612 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 546 | 5 | 1 | 7 | 5.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3c2CCc2ccccc2C3=O)cc1 | 10.1021/jm9606507 | |||
CHEMBL276601 | 98612 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 546 | 5 | 1 | 7 | 5.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3c2CCc2ccccc2C3=O)cc1 | 10.1021/jm9606507 | |||
10627398 | 130755 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 599 | 11 | 4 | 5 | 5.8 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)o1 | 10.1021/jm950591h | |||
CHEMBL368339 | 130755 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 599 | 11 | 4 | 5 | 5.8 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)o1 | 10.1021/jm950591h | |||
10841170 | 12123 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | |||
CHEMBL1184090 | 12123 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | |||
CHEMBL332109 | 12123 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | |||
10579647 | 168581 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 612 | 11 | 4 | 5 | 5.8 | Cc1c(C(=O)O)nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)n1Cc1ccccc1 | 10.1021/jm950592+ | |||
CHEMBL435156 | 168581 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 612 | 11 | 4 | 5 | 5.8 | Cc1c(C(=O)O)nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)n1Cc1ccccc1 | 10.1021/jm950592+ | |||
10575061 | 209351 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 439 | 9 | 1 | 6 | 4.0 | CCCCC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9082 | 209351 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 439 | 9 | 1 | 6 | 4.0 | CCCCC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
10646637 | 209506 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 437 | 8 | 1 | 5 | 4.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C/C=C/CC(C)C)cc1 | 10.1021/jm9505369 | |||
CHEMBL9168 | 209506 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 437 | 8 | 1 | 5 | 4.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C/C=C/CC(C)C)cc1 | 10.1021/jm9505369 | |||
44368416 | 44706 | None | 0 | Pig | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 540 | 8 | 2 | 6 | 5.6 | O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)Cc1cc2c(cc1Cl)OCO2 | 10.1016/s0960-894x(01)00009-9 | |||
CHEMBL152098 | 44706 | None | 0 | Pig | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 540 | 8 | 2 | 6 | 5.6 | O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)Cc1cc2c(cc1Cl)OCO2 | 10.1016/s0960-894x(01)00009-9 | |||
10478562 | 131866 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 442 | 6 | 1 | 6 | 4.5 | Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00132-7 | |||
CHEMBL369359 | 131866 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 442 | 6 | 1 | 6 | 4.5 | Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00132-7 | |||
127026043 | 137440 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 607 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
CHEMBL3752947 | 137440 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 607 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
44386162 | 60429 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 575 | 11 | 1 | 9 | 6.2 | CC/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL175005 | 60429 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 575 | 11 | 1 | 9 | 6.2 | CC/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
10503334 | 173448 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 441 | 5 | 2 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br | 10.1016/S0960-894X(97)00367-3 | |||
CHEMBL45269 | 173448 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 441 | 5 | 2 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br | 10.1016/S0960-894X(97)00367-3 | |||
10503334 | 173448 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 441 | 5 | 2 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br | 10.1021/jm9608366 | |||
CHEMBL45269 | 173448 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 441 | 5 | 2 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br | 10.1021/jm9608366 | |||
10140871 | 59269 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 484 | 9 | 2 | 9 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)ncnc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL170342 | 59269 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 484 | 9 | 2 | 9 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)ncnc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
44383754 | 59903 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 452 | 5 | 1 | 5 | 5.4 | Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | |||
CHEMBL172987 | 59903 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 452 | 5 | 1 | 5 | 5.4 | Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | |||
CHEMBL319660 | 213679 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | |||||
11005243 | 205839 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
CHEMBL65337 | 205839 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
9801093 | 59254 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 399 | 7 | 1 | 5 | 5.1 | N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm990378b | |||
CHEMBL170296 | 59254 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 399 | 7 | 1 | 5 | 5.1 | N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm990378b | |||
44295089 | 14638 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 476 | 8 | 1 | 7 | 5.4 | COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL1205088 | 14638 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 476 | 8 | 1 | 7 | 5.4 | COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | |||
CHEMBL51030 | 14638 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 476 | 8 | 1 | 7 | 5.4 | COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | |||
44320192 | 107112 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 480 | 6 | 1 | 5 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1cccc(Cl)c1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL315622 | 107112 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 480 | 6 | 1 | 5 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1cccc(Cl)c1 | 10.1016/s0960-894x(00)00513-8 | |||
10504542 | 179669 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 469 | 6 | 2 | 6 | 4.4 | CCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | |||
CHEMBL47418 | 179669 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 469 | 6 | 2 | 6 | 4.4 | CCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | |||
44386536 | 130781 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 549 | 10 | 4 | 6 | 4.9 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2F)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL368461 | 130781 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 549 | 10 | 4 | 6 | 4.9 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2F)nc1C(=O)O | 10.1021/jm950592+ | |||
10626245 | 131230 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 539 | 10 | 2 | 8 | 5.5 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)OC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | |||
CHEMBL368629 | 131230 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 539 | 10 | 2 | 8 | 5.5 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)OC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | |||
44311516 | 206576 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 678 | 12 | 2 | 12 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL70339 | 206576 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 678 | 12 | 2 | 12 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | |||
137633242 | 156571 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 569 | 10 | 2 | 10 | 3.8 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCOC)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
CHEMBL4067475 | 156571 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 569 | 10 | 2 | 10 | 3.8 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCOC)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | |||
10599230 | 209453 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 440 | 8 | 2 | 6 | 2.8 | CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9141 | 209453 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 440 | 8 | 2 | 6 | 2.8 | CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
71458718 | 81705 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 615 | 14 | 1 | 12 | 4.3 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163700 | 81705 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 615 | 14 | 1 | 12 | 4.3 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C)cn1 | 10.1021/jm3009103 | |||
44320783 | 106749 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 453 | 6 | 1 | 6 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccnc2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL314357 | 106749 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 453 | 6 | 1 | 6 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccnc2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | |||
18995986 | 99635 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 537 | 8 | 1 | 10 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL283858 | 99635 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 537 | 8 | 1 | 10 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | |||
18617379 | 207682 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 364 | 3 | 1 | 4 | 3.5 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL78669 | 207682 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 364 | 3 | 1 | 4 | 3.5 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1Br | 10.1016/0960-894X(96)00441-6 | |||
10622616 | 8060 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 432 | 5 | 1 | 6 | 4.5 | CSc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | |||
CHEMBL10911 | 8060 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 432 | 5 | 1 | 6 | 4.5 | CSc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | |||
10412464 | 9139 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 470 | 6 | 1 | 5 | 5.4 | COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | |||
CHEMBL10996 | 9139 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 470 | 6 | 1 | 5 | 5.4 | COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | |||
11826883 | 202607 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 476 | 8 | 1 | 6 | 5.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)c(OC)c3)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL59635 | 202607 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 476 | 8 | 1 | 6 | 5.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)c(OC)c3)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | |||
11017198 | 109069 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 563 | 12 | 1 | 8 | 6.0 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOCc2ccccc2)c1 | 10.1021/jm0102304 | |||
CHEMBL321226 | 109069 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 563 | 12 | 1 | 8 | 6.0 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOCc2ccccc2)c1 | 10.1021/jm0102304 | |||
10765567 | 111417 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 440 | 9 | 1 | 5 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2cccc(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL326951 | 111417 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 440 | 9 | 1 | 5 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2cccc(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
9870117 | 195547 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 488 | 10 | 1 | 7 | 5.5 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL54057 | 195547 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 488 | 10 | 1 | 7 | 5.5 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 | 10.1016/j.bmcl.2016.06.014 | |||
9870117 | 195547 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 488 | 10 | 1 | 7 | 5.5 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 | 10.1016/s0960-894x(00)00366-8 | |||
CHEMBL54057 | 195547 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 488 | 10 | 1 | 7 | 5.5 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 | 10.1016/s0960-894x(00)00366-8 | |||
44277367 | 106894 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 392 | 4 | 2 | 5 | 3.3 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144606 | 106894 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 392 | 4 | 2 | 5 | 3.3 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
44387128 | 168692 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 558 | 12 | 2 | 10 | 3.8 | CNCC(=O)OCCOc1nc(C)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL435895 | 168692 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 558 | 12 | 2 | 10 | 3.8 | CNCC(=O)OCCOc1nc(C)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL422464 | 215747 | None | 0 | Pig | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
5310990 | 166926 | None | 8 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 2 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL428504 | 166926 | None | 8 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 2 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
23445506 | 112621 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 428 | 5 | 1 | 6 | 4.3 | COc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL330003 | 112621 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 428 | 5 | 1 | 6 | 4.3 | COc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
10452145 | 98257 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 376 | 5 | 1 | 7 | 2.9 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1[N+](=O)[O-] | 10.1021/jm00008a013 | |||
CHEMBL27420 | 98257 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 376 | 5 | 1 | 7 | 2.9 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1[N+](=O)[O-] | 10.1021/jm00008a013 | |||
10813007 | 113383 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 440 | 9 | 1 | 5 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL331577 | 113383 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 440 | 9 | 1 | 5 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
44384852 | 60260 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 544 | 9 | 1 | 8 | 5.5 | C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL174094 | 60260 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 544 | 9 | 1 | 8 | 5.5 | C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
10362674 | 97835 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 385 | 4 | 1 | 5 | 4.2 | Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCCC4)cccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL27178 | 97835 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 385 | 4 | 1 | 5 | 4.2 | Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCCC4)cccc23)c1C | 10.1021/jm00008a013 | |||
10742446 | 209470 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 456 | 9 | 2 | 7 | 2.0 | COCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL9147 | 209470 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 456 | 9 | 2 | 7 | 2.0 | COCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
10650638 | 9186 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 566 | 13 | 1 | 6 | 4.8 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 | 10.1021/jm970101g | |||
CHEMBL110305 | 9186 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 566 | 13 | 1 | 6 | 4.8 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 | 10.1021/jm970101g | |||
10647898 | 97399 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 466 | 5 | 1 | 6 | 5.0 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3ccccc23)cc1 | 10.1021/jm9606507 | |||
CHEMBL269409 | 97399 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 466 | 5 | 1 | 6 | 5.0 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3ccccc23)cc1 | 10.1021/jm9606507 | |||
10993781 | 203806 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 434 | 7 | 1 | 7 | 5.0 | CCCCC1=C(c2nnn[nH]2)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL60440 | 203806 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 434 | 7 | 1 | 7 | 5.0 | CCCCC1=C(c2nnn[nH]2)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
10896412 | 205262 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 504 | 9 | 1 | 7 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1OC)O2 | 10.1021/jm010382z | |||
CHEMBL62277 | 205262 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 504 | 9 | 1 | 7 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1OC)O2 | 10.1021/jm010382z | |||
15410997 | 4710 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 563 | 8 | 1 | 7 | 6.3 | COc1ccc(C2(OC(=O)N[C@@H](C)c3ccccc3)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1016/S0960-894X(97)00002-4 | |||
CHEMBL103501 | 4710 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 563 | 8 | 1 | 7 | 6.3 | COc1ccc(C2(OC(=O)N[C@@H](C)c3ccccc3)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1016/S0960-894X(97)00002-4 | |||
CHEMBL2370534 | 212328 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](N)Cc2ccccc2)C(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm990170q | |||||
151174 | 205177 | None | 35 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 605 | 12 | 3 | 13 | 3.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL61780 | 205177 | None | 35 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 605 | 12 | 3 | 13 | 3.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
76319370 | 85390 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 564 | 8 | 1 | 9 | 4.0 | CCOC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 | 10.1007/s00044-004-0021-y | |||
CHEMBL2261602 | 85390 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 564 | 8 | 1 | 9 | 4.0 | CCOC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 | 10.1007/s00044-004-0021-y | |||
10050696 | 96831 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 476 | 7 | 1 | 6 | 5.3 | COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL26474 | 96831 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 476 | 7 | 1 | 6 | 5.3 | COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | |||
10050696 | 96831 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 476 | 7 | 1 | 6 | 5.3 | COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL26474 | 96831 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 476 | 7 | 1 | 6 | 5.3 | COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
10138169 | 99415 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | |||
CHEMBL282470 | 99415 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | |||
10211772 | 56539 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 660 | 11 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL163638 | 56539 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 660 | 11 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | |||
10165809 | 131867 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 541 | 9 | 2 | 11 | 2.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL369362 | 131867 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 541 | 9 | 2 | 11 | 2.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL61900 | 218331 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00349-X | |||||
44327412 | 210040 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 497 | 5 | 1 | 8 | 3.0 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | |||
CHEMBL94929 | 210040 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 497 | 5 | 1 | 8 | 3.0 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | |||
44385621 | 128263 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 550 | 10 | 5 | 5 | 4.6 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL366544 | 128263 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 550 | 10 | 5 | 5 | 4.6 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O | 10.1021/jm950592+ | |||
44356917 | 119305 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 638 | 8 | 5 | 8 | 0.3 | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2cn(C=O)c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||
CHEMBL343516 | 119305 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 638 | 8 | 5 | 8 | 0.3 | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2cn(C=O)c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||
CHEMBL2370825 | 212387 | None | 0 | Pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2C[C@@H](O)CN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
11091217 | 101121 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 426 | 9 | 1 | 6 | 5.0 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cc(OCCC)ccc21 | 10.1021/jm010382z | |||
CHEMBL294787 | 101121 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 426 | 9 | 1 | 6 | 5.0 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cc(OCCC)ccc21 | 10.1021/jm010382z | |||
44314722 | 155841 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 597 | 14 | 5 | 4 | 4.9 | CCCCC(NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL405724 | 155841 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 597 | 14 | 5 | 4 | 4.9 | CCCCC(NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL293216 | 213348 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00349-X | |||||
44283421 | 100211 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 597 | 14 | 5 | 4 | 4.9 | CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | |||
CHEMBL287888 | 100211 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 597 | 14 | 5 | 4 | 4.9 | CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | |||
44383742 | 168608 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 452 | 5 | 1 | 5 | 5.4 | Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | |||
CHEMBL435346 | 168608 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 452 | 5 | 1 | 5 | 5.4 | Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | |||
CHEMBL137361 | 211203 | None | 0 | Pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL313382 | 213572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
CHEMBL86814 | 218382 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
44368819 | 168995 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1637 | 31 | 19 | 20 | 1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||
77282140 | 168995 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1637 | 31 | 19 | 20 | 1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||
CHEMBL438380 | 168995 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1637 | 31 | 19 | 20 | 1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||
44316973 | 208063 | None | 1 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1C | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL81593 | 208063 | None | 1 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1C | 10.1016/0960-894X(96)00441-6 | |||
127035067 | 136479 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 683 | 12 | 2 | 9 | 5.4 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
CHEMBL3735236 | 136479 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 683 | 12 | 2 | 9 | 5.4 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
44368824 | 96880 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1595 | 31 | 19 | 20 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||
77282142 | 96880 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1595 | 31 | 19 | 20 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||
CHEMBL265164 | 96880 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1595 | 31 | 19 | 20 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||
CHEMBL436899 | 216155 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||||
44277034 | 106899 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1ccccc1Cn1[nH]c(C(F)(F)F)c(Cc2ccc3c(c2)OCO3)c1=O | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144729 | 106899 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1ccccc1Cn1[nH]c(C(F)(F)F)c(Cc2ccc3c(c2)OCO3)c1=O | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL1791279 | 211378 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00152-J | |||||
171348836 | 193851 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 439 | 7 | 2 | 6 | 3.3 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccccc1)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.0c01093 | |||
CHEMBL5272983 | 193851 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 439 | 7 | 2 | 6 | 3.3 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccccc1)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.0c01093 | |||
19735343 | 176155 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 473 | 7 | 2 | 6 | 4.0 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4590568 | 176155 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 473 | 7 | 2 | 6 | 4.0 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
23445516 | 106684 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 468 | 7 | 1 | 5 | 5.9 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CCC(C)C)cc2)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL314307 | 106684 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 468 | 7 | 1 | 5 | 5.9 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CCC(C)C)cc2)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
23445354 | 209093 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 426 | 5 | 1 | 5 | 4.8 | CCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL89203 | 209093 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 426 | 5 | 1 | 5 | 4.8 | CCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL273391 | 213268 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
CHEMBL273391 | 213268 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | |||||
18184206 | 60352 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 600 | 13 | 2 | 11 | 3.2 | CCS(=O)(=O)NCCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL174413 | 60352 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 600 | 13 | 2 | 11 | 3.2 | CCS(=O)(=O)NCCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
44385792 | 60371 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 617 | 13 | 2 | 11 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL174547 | 60371 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 617 | 13 | 2 | 11 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | |||
44384966 | 60017 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 545 | 9 | 1 | 9 | 4.8 | C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL173465 | 60017 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 545 | 9 | 1 | 9 | 4.8 | C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
71460537 | 81728 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 660 | 12 | 1 | 13 | 2.7 | COc1ccccc1Oc1c(NS(=O)(=O)N2CCOCC2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163722 | 81728 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 660 | 12 | 1 | 13 | 2.7 | COc1ccccc1Oc1c(NS(=O)(=O)N2CCOCC2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
10765057 | 163255 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 430 | 4 | 1 | 7 | 3.5 | O=C1OC(O)(c2ccc3c(c2)OCO3)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm9606507 | |||
CHEMBL417978 | 163255 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 430 | 4 | 1 | 7 | 3.5 | O=C1OC(O)(c2ccc3c(c2)OCO3)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm9606507 | |||
CHEMBL2304012 | 211927 | None | 0 | Pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | None | None | None | CC(C)[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC1=O | 10.1021/jm9600914 | |||||
44458399 | 99046 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 520 | 7 | 2 | 7 | 4.2 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | |||
CHEMBL279947 | 99046 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 520 | 7 | 2 | 7 | 4.2 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | |||
73669992 | 117695 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 387 | 9 | 1 | 4 | 5.4 | N#CCCC(Oc1cc(OCc2ccccc2)ccc1C(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | |||
CHEMBL3400998 | 117695 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 387 | 9 | 1 | 4 | 5.4 | N#CCCC(Oc1cc(OCc2ccccc2)ccc1C(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | |||
10814776 | 99527 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 485 | 5 | 2 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9608366 | |||
10814776 | 99527 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 485 | 5 | 2 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | |||
CHEMBL283136 | 99527 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 485 | 5 | 2 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9608366 | |||
CHEMBL283136 | 99527 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 485 | 5 | 2 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | |||
44387111 | 166277 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 548 | 10 | 5 | 5 | 4.2 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL426413 | 166277 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 548 | 10 | 5 | 5 | 4.2 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O | 10.1021/jm950592+ | |||
9830773 | 130294 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 2 | ChEMBL | 636 | 14 | 2 | 12 | 2.8 | CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
CHEMBL367958 | 130294 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 2 | ChEMBL | 636 | 14 | 2 | 12 | 2.8 | CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | |||
10814776 | 99527 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 485 | 5 | 2 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm000349x | |||
CHEMBL283136 | 99527 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 485 | 5 | 2 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm000349x | |||
CHEMBL341994 | 214120 | None | 0 | Pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C2=CCC=CC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
10410546 | 9414 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | |||
CHEMBL11162 | 9414 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | |||
44279481 | 112446 | None | 0 | Pig | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 555 | 11 | 5 | 4 | 4.0 | CC(C)C[C@H](NC(=O)N1C(C)(C)CCCC1(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O | 10.1016/0960-894X(95)00221-E | |||
CHEMBL32959 | 112446 | None | 0 | Pig | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 555 | 11 | 5 | 4 | 4.0 | CC(C)C[C@H](NC(=O)N1C(C)(C)CCCC1(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O | 10.1016/0960-894X(95)00221-E | |||
10674095 | 113577 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 544 | 9 | 1 | 6 | 5.1 | CCc1cccc(CC)c1N(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | |||
CHEMBL332093 | 113577 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 544 | 9 | 1 | 6 | 5.1 | CCc1cccc(CC)c1N(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | |||
CHEMBL135906 | 211193 | None | 0 | Pig | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
44316983 | 104852 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 312 | 5 | 1 | 6 | 2.1 | COc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1OC | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL310944 | 104852 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 312 | 5 | 1 | 6 | 2.1 | COc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1OC | 10.1016/0960-894X(96)00441-6 | |||
44371670 | 141750 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 1082 | 23 | 11 | 10 | 3.7 | CC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C1c2ccccc2CCc2ccccc21 | 10.1016/0960-894X(95)00084-7 | |||
CHEMBL385405 | 141750 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 1082 | 23 | 11 | 10 | 3.7 | CC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C1c2ccccc2CCc2ccccc21 | 10.1016/0960-894X(95)00084-7 | |||
44277035 | 106908 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 410 | 4 | 1 | 4 | 4.2 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(Cl)c1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144806 | 106908 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 410 | 4 | 1 | 4 | 4.2 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(Cl)c1 | 10.1016/s0960-894x(00)00232-8 | |||
10554385 | 60235 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 537 | 10 | 4 | 5 | 4.8 | CCc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O | 10.1021/jm950591h | |||
CHEMBL174000 | 60235 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 537 | 10 | 4 | 5 | 4.8 | CCc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O | 10.1021/jm950591h | |||
10721963 | 60579 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 580 | 11 | 5 | 6 | 3.7 | Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)NCC(=O)O | 10.1021/jm950592+ | |||
CHEMBL175924 | 60579 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 580 | 11 | 5 | 6 | 3.7 | Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)NCC(=O)O | 10.1021/jm950592+ | |||
44386620 | 170708 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 549 | 10 | 4 | 6 | 4.9 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccc(F)cc2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL445076 | 170708 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 549 | 10 | 4 | 6 | 4.9 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccc(F)cc2)nc1C(=O)O | 10.1021/jm950592+ | |||
44311218 | 103182 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 607 | 11 | 2 | 10 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccncc1 | 10.1016/S0960-894X(97)00400-9 | |||
CHEMBL307803 | 103182 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 607 | 11 | 2 | 10 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccncc1 | 10.1016/S0960-894X(97)00400-9 | |||
18617344 | 207736 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 361 | 4 | 1 | 6 | 2.5 | Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL79080 | 207736 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 361 | 4 | 1 | 6 | 2.5 | Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1Br | 10.1016/0960-894X(96)00441-6 | |||
15342056 | 209471 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 322 | 3 | 1 | 5 | 2.6 | Cc1noc(NS(=O)(=O)c2cccs2)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL91470 | 209471 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 322 | 3 | 1 | 5 | 2.6 | Cc1noc(NS(=O)(=O)c2cccs2)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
10503976 | 11242 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 455 | 5 | 1 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N(C)c2ccccc2)c1Br | 10.1021/jm9608366 | |||
CHEMBL1178874 | 11242 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 455 | 5 | 1 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N(C)c2ccccc2)c1Br | 10.1021/jm9608366 | |||
CHEMBL47536 | 11242 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 455 | 5 | 1 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N(C)c2ccccc2)c1Br | 10.1021/jm9608366 | |||
10211543 | 131453 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 640 | 13 | 2 | 12 | 3.5 | CCCCNC(=O)OCC#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL368989 | 131453 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 640 | 13 | 2 | 12 | 3.5 | CCCCNC(=O)OCC#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | |||
10341117 | 163292 | None | 1 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 403 | 8 | 3 | 6 | 3.5 | Cc1noc(NS(=O)(=O)c2cccc3c(NCCCC(=O)O)cccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL418202 | 163292 | None | 1 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 403 | 8 | 3 | 6 | 3.5 | Cc1noc(NS(=O)(=O)c2cccc3c(NCCCC(=O)O)cccc23)c1C | 10.1021/jm00008a013 | |||
10554085 | 101341 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 524 | 6 | 1 | 9 | 3.2 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N2CCN(Cc3ccc4c(c3)OCO4)CC2)c1Cl | 10.1021/jm9700068 | |||
CHEMBL296427 | 101341 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 524 | 6 | 1 | 9 | 3.2 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N2CCN(Cc3ccc4c(c3)OCO4)CC2)c1Cl | 10.1021/jm9700068 | |||
10817024 | 12132 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 578 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | |||
CHEMBL1184112 | 12132 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 578 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | |||
CHEMBL332808 | 12132 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 578 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | |||
44279140 | 110695 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 588 | 12 | 2 | 6 | 5.8 | CCCCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
CHEMBL32574 | 110695 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 588 | 12 | 2 | 6 | 5.8 | CCCCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
11793037 | 206165 | None | 1 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 3.2 | CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nn3)cccc12 | 10.1021/jm9604585 | |||
CHEMBL6761 | 206165 | None | 1 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 3.2 | CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nn3)cccc12 | 10.1021/jm9604585 | |||
9885296 | 97022 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 361 | 4 | 1 | 4 | 3.8 | CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)cn3)cccc12 | 10.1021/jm9604585 | |||
CHEMBL266315 | 97022 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 361 | 4 | 1 | 4 | 3.8 | CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)cn3)cccc12 | 10.1021/jm9604585 | |||
10786783 | 205893 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 393 | 4 | 1 | 5 | 3.2 | COc1nc(Br)cnc1NS(=O)(=O)c1cccc2ccccc12 | 10.1021/jm9604585 | |||
CHEMBL6576 | 205893 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 393 | 4 | 1 | 5 | 3.2 | COc1nc(Br)cnc1NS(=O)(=O)c1cccc2ccccc12 | 10.1021/jm9604585 | |||
10740137 | 205971 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 406 | 4 | 1 | 5 | 3.3 | CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)cn3)cccc12 | 10.1021/jm9604585 | |||
CHEMBL6630 | 205971 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 406 | 4 | 1 | 5 | 3.3 | CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)cn3)cccc12 | 10.1021/jm9604585 | |||
10230836 | 8911 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 13 | 1 | 7 | 4.1 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | |||
CHEMBL109765 | 8911 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 13 | 1 | 7 | 4.1 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | |||
10209319 | 9372 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 13 | 1 | 7 | 4.1 | CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC | 10.1021/jm970101g | |||
CHEMBL111355 | 9372 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 13 | 1 | 7 | 4.1 | CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC | 10.1021/jm970101g | |||
10507211 | 110427 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 566 | 13 | 1 | 7 | 3.9 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCCCl | 10.1021/jm970101g | |||
CHEMBL324214 | 110427 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 566 | 13 | 1 | 7 | 3.9 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCCCl | 10.1021/jm970101g | |||
9807691 | 100118 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 553 | 10 | 1 | 10 | 5.3 | COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL287169 | 100118 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 553 | 10 | 1 | 10 | 5.3 | COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | |||
11732669 | 205575 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 426 | 9 | 1 | 6 | 5.0 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCC)cc21 | 10.1021/jm010382z | |||
CHEMBL64039 | 205575 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 426 | 9 | 1 | 6 | 5.0 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCC)cc21 | 10.1021/jm010382z | |||
10602267 | 8589 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 529 | 13 | 1 | 6 | 3.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCCC1=O | 10.1021/jm980217s | |||
CHEMBL109478 | 8589 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 529 | 13 | 1 | 6 | 3.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCCC1=O | 10.1021/jm980217s | |||
44332842 | 109777 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 703 | 11 | 1 | 10 | 7.5 | COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/S0960-894X(97)00002-4 | |||
CHEMBL322920 | 109777 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 703 | 11 | 1 | 10 | 7.5 | COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/S0960-894X(97)00002-4 | |||
44315009 | 103261 | None | 0 | Pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 665 | 13 | 5 | 5 | 4.7 | CSCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL308403 | 103261 | None | 0 | Pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 665 | 13 | 5 | 5 | 4.7 | CSCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
10791702 | 198272 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL558148 | 198272 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
9895957 | 10676 | None | 19 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 3 | 3 | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1039/C4MD00499J | |||
CHEMBL11706 | 10676 | None | 19 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 3 | 3 | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1039/C4MD00499J | |||
21041288 | 174030 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 526 | 10 | 2 | 9 | 2.8 | CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4540866 | 174030 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 526 | 10 | 2 | 9 | 2.8 | CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
155563100 | 175380 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 619 | 13 | 2 | 10 | 4.6 | COc1cnc(OCCOc2nc(-c3ccncc3)nc(NS(=O)(=O)NCc3ccccc3)c2-c2ccc(Cl)cc2)nc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4572734 | 175380 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 619 | 13 | 2 | 10 | 4.6 | COc1cnc(OCCOc2nc(-c3ccncc3)nc(NS(=O)(=O)NCc3ccccc3)c2-c2ccc(Cl)cc2)nc1 | 10.1016/j.bmcl.2016.06.014 | |||
9829478 | 175429 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 567 | 10 | 1 | 8 | 4.9 | Cc1ccc(-c2c(NS(=O)(=O)/C=C/c3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4573806 | 175429 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 567 | 10 | 1 | 8 | 4.9 | Cc1ccc(-c2c(NS(=O)(=O)/C=C/c3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
10146377 | 60434 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 662 | 11 | 2 | 14 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL175058 | 60434 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 662 | 11 | 2 | 14 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
10816682 | 102196 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 559 | 10 | 1 | 9 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCOCC3)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL302493 | 102196 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 559 | 10 | 1 | 9 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCOCC3)c2)cc1 | 10.1021/jm980504w | |||
10579885 | 102762 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 632 | 12 | 1 | 11 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCN(C)CC3)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL304802 | 102762 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 632 | 12 | 1 | 11 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCN(C)CC3)c2)cc1 | 10.1021/jm980504w | |||
10814440 | 98200 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)ccc2OC)cc1 | 10.1021/jm9606507 | |||
CHEMBL273723 | 98200 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)ccc2OC)cc1 | 10.1021/jm9606507 | |||
71462247 | 81729 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2cnccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163723 | 81729 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2cnccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
23548253 | 81707 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 679 | 14 | 1 | 12 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL2163702 | 81707 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 679 | 14 | 1 | 12 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1016/j.bmcl.2016.06.014 | |||
11014820 | 205370 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 398 | 6 | 1 | 6 | 4.2 | CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
CHEMBL62780 | 205370 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 398 | 6 | 1 | 6 | 4.2 | CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | |||
10602183 | 9241 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 525 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1ccccc1=O | 10.1021/jm980217s | |||
CHEMBL110695 | 9241 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 525 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1ccccc1=O | 10.1021/jm980217s | |||
10625152 | 110522 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 498 | 13 | 1 | 6 | 4.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccoc1 | 10.1021/jm980217s | |||
CHEMBL324685 | 110522 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 498 | 13 | 1 | 6 | 4.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccoc1 | 10.1021/jm980217s | |||
90766557 | 170631 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 528 | 10 | 2 | 8 | 3.1 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4449731 | 170631 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 528 | 10 | 2 | 8 | 3.1 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
76312118 | 85381 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 691 | 2 | ChEMBL | 522 | 7 | 2 | 8 | 3.4 | COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 | 10.1007/s00044-004-0021-y | |||
CHEMBL2261361 | 85381 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 691 | 2 | ChEMBL | 522 | 7 | 2 | 8 | 3.4 | COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 | 10.1007/s00044-004-0021-y | |||
9916121 | 81698 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 571 | 10 | 1 | 8 | 4.1 | CCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
CHEMBL2163693 | 81698 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 571 | 10 | 1 | 8 | 4.1 | CCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | |||
23548253 | 81707 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 679 | 14 | 1 | 12 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163702 | 81707 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 679 | 14 | 1 | 12 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | |||
44334130 | 4511 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 458 | 5 | 1 | 6 | 4.4 | COc1ccc([C@@H]2c3nc(N4CCCC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL102173 | 4511 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 458 | 5 | 1 | 6 | 4.4 | COc1ccc([C@@H]2c3nc(N4CCCC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
9808602 | 109265 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 590 | 15 | 1 | 8 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 | 10.1021/jm970101g | |||
CHEMBL321673 | 109265 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 590 | 15 | 1 | 8 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 | 10.1021/jm970101g | |||
11826062 | 205447 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 426 | 8 | 2 | 6 | 4.3 | CC(C)Oc1ccc2c(c1)C(CCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
CHEMBL63113 | 205447 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 426 | 8 | 2 | 6 | 4.3 | CC(C)Oc1ccc2c(c1)C(CCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | |||
10696876 | 110392 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 504 | 13 | 1 | 7 | 3.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCO1 | 10.1021/jm980217s | |||
CHEMBL323989 | 110392 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 504 | 13 | 1 | 7 | 3.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCO1 | 10.1021/jm980217s | |||
22467235 | 96578 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 533 | 7 | 2 | 7 | 3.8 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | |||
CHEMBL262784 | 96578 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 533 | 7 | 2 | 7 | 3.8 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | |||
22467235 | 96578 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 533 | 7 | 2 | 7 | 3.8 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1007/s00044-004-0021-y | |||
CHEMBL262784 | 96578 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 533 | 7 | 2 | 7 | 3.8 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1007/s00044-004-0021-y | |||
71462321 | 82038 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 584 | 12 | 2 | 8 | 4.2 | CCc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | |||
CHEMBL2165335 | 82038 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 584 | 12 | 2 | 8 | 4.2 | CCc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | |||
9890440 | 8256 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 460 | 6 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 | 10.1021/jm9606507 | |||
CHEMBL10924 | 8256 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 460 | 6 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 | 10.1021/jm9606507 | |||
10577306 | 109744 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 499 | 13 | 1 | 7 | 3.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ncco1 | 10.1021/jm980217s | |||
CHEMBL322732 | 109744 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 499 | 13 | 1 | 7 | 3.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ncco1 | 10.1021/jm980217s | |||
44315007 | 207006 | None | 0 | Pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 679 | 14 | 5 | 5 | 5.1 | CCCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL72891 | 207006 | None | 0 | Pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 679 | 14 | 5 | 5 | 5.1 | CCCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
21041273 | 173852 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 538 | 12 | 2 | 9 | 2.8 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4536769 | 173852 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 538 | 12 | 2 | 9 | 2.8 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | |||
9821701 | 4614 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 389 | 4 | 1 | 5 | 3.8 | COc1ccc([C@@H]2c3ncccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
CHEMBL102825 | 4614 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 389 | 4 | 1 | 5 | 3.8 | COc1ccc([C@@H]2c3ncccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | |||
10698065 | 12117 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 558 | 11 | 2 | 6 | 5.6 | CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | |||
CHEMBL1184065 | 12117 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 558 | 11 | 2 | 6 | 5.6 | CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | |||
CHEMBL330895 | 12117 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 558 | 11 | 2 | 6 | 5.6 | CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | |||
CHEMBL171198 | 211305 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)O | 10.1016/0960-894X(95)00144-I | |||||
10529742 | 8194 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 511 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1cccn1C | 10.1021/jm980217s | |||
CHEMBL109206 | 8194 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 511 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1cccn1C | 10.1021/jm980217s | |||
10116355 | 8268 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 474 | 14 | 1 | 5 | 4.9 | CCCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
CHEMBL109248 | 8268 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 474 | 14 | 1 | 5 | 4.9 | CCCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | |||
10648715 | 109725 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 488 | 14 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC(C)C | 10.1021/jm980217s | |||
CHEMBL322547 | 109725 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 488 | 14 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC(C)C | 10.1021/jm980217s | |||
44320291 | 105994 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 548 | 7 | 2 | 8 | 4.8 | O=C(O)c1cc2c(c(Cn3nc(-c4ccccc4)c(Cc4cc5c(cc4Cl)OCO5)c3C(=O)O)c1)OCOC2 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL312854 | 105994 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 548 | 7 | 2 | 8 | 4.8 | O=C(O)c1cc2c(c(Cn3nc(-c4ccccc4)c(Cc4cc5c(cc4Cl)OCO5)c3C(=O)O)c1)OCOC2 | 10.1016/s0960-894x(00)00513-8 | |||
17885912 | 107155 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 496 | 7 | 2 | 6 | 5.1 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCC(C(=O)O)C1 | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL315936 | 107155 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 496 | 7 | 2 | 6 | 5.1 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCC(C(=O)O)C1 | 10.1016/s0960-894x(00)00513-8 | |||
44279295 | 106058 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 482 | 8 | 1 | 6 | 4.2 | COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
CHEMBL31324 | 106058 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 482 | 8 | 1 | 6 | 4.2 | COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 | 10.1016/S0960-894X(97)00228-X | |||
10670600 | 96629 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 436 | 6 | 2 | 6 | 3.6 | CCNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 | 10.1021/jm9604585 | |||
CHEMBL263079 | 96629 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 436 | 6 | 2 | 6 | 3.6 | CCNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 | 10.1021/jm9604585 | |||
10646831 | 184026 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9608366 | |||
10646831 | 184026 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9700068 | |||
CHEMBL48134 | 184026 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9608366 | |||
CHEMBL48134 | 184026 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9700068 | |||
11751754 | 102416 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 469 | 6 | 3 | 7 | 4.1 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 | 10.1021/jm030528p | |||
CHEMBL303806 | 102416 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 469 | 6 | 3 | 7 | 4.1 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 | 10.1021/jm030528p | |||
10555516 | 9243 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 598 | 12 | 1 | 7 | 4.6 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)Cc1ccccc1 | 10.1021/jm970101g | |||
CHEMBL110700 | 9243 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 598 | 12 | 1 | 7 | 4.6 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)Cc1ccccc1 | 10.1021/jm970101g | |||
11799503 | 9755 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 498 | 13 | 1 | 6 | 4.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccco1 | 10.1021/jm980217s | |||
CHEMBL113472 | 9755 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 498 | 13 | 1 | 6 | 4.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccco1 | 10.1021/jm980217s | |||
10289311 | 110498 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 514 | 13 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C=C(C)C | 10.1021/jm980217s | |||
CHEMBL324586 | 110498 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 514 | 13 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C=C(C)C | 10.1021/jm980217s | |||
CHEMBL2304007 | 211922 | None | 0 | Pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | None | None | None | Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O | 10.1021/jm9600914 | |||||
44380954 | 57694 | None | 0 | Pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 643 | 11 | 1 | 10 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOc1ncc(Br)cn1 | 10.1016/s0960-894x(01)00682-5 | |||
CHEMBL166875 | 57694 | None | 0 | Pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 643 | 11 | 1 | 10 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOc1ncc(Br)cn1 | 10.1016/s0960-894x(01)00682-5 | |||
10525281 | 182956 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 404 | 6 | 1 | 6 | 4.2 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 | 10.1021/jm9700068 | |||
CHEMBL47915 | 182956 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 404 | 6 | 1 | 6 | 4.2 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 | 10.1021/jm9700068 | |||
9888574 | 104231 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 422 | 4 | 1 | 4 | 3.9 | CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL309692 | 104231 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 422 | 4 | 1 | 4 | 3.9 | CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | |||
11102844 | 205699 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 476 | 7 | 2 | 7 | 4.2 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)CO)cc32)cc1 | 10.1021/jm010382z | |||
CHEMBL64536 | 205699 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 476 | 7 | 2 | 7 | 4.2 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)CO)cc32)cc1 | 10.1021/jm010382z | |||
44314906 | 103633 | None | 0 | Pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 607 | 12 | 6 | 5 | 3.4 | Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)NC(Cc1c[nH]cn1)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL308621 | 103633 | None | 0 | Pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 607 | 12 | 6 | 5 | 3.4 | Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)NC(Cc1c[nH]cn1)C(=O)O | 10.1021/jm9600914 | |||
44458670 | 99106 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 521 | 7 | 2 | 8 | 2.7 | COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | |||
CHEMBL280379 | 99106 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 521 | 7 | 2 | 8 | 2.7 | COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | |||
71455060 | 81694 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 614 | 9 | 1 | 9 | 2.9 | O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)N1CCOCC1 | 10.1021/jm3009103 | |||
CHEMBL2163689 | 81694 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 614 | 9 | 1 | 9 | 2.9 | O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)N1CCOCC1 | 10.1021/jm3009103 | |||
71451526 | 81706 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 635 | 14 | 1 | 12 | 4.6 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Cl)cn1 | 10.1021/jm3009103 | |||
CHEMBL2163701 | 81706 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 635 | 14 | 1 | 12 | 4.6 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Cl)cn1 | 10.1021/jm3009103 | |||
10875868 | 115025 | None | 0 | Pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 619 | 9 | 1 | 8 | 5.0 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Br)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
CHEMBL334263 | 115025 | None | 0 | Pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 619 | 9 | 1 | 8 | 5.0 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Br)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | |||
9810190 | 103121 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 563 | 11 | 1 | 10 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN(C)C)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL307330 | 103121 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 563 | 11 | 1 | 10 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN(C)C)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL2304015 | 211930 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | None | None | None | Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O | 10.1021/jm9600914 | |||||
10875239 | 9589 | None | 0 | Pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 541 | 10 | 1 | 10 | 4.8 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccco2)nc1 | 10.1021/jm0102304 | |||
CHEMBL112502 | 9589 | None | 0 | Pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 541 | 10 | 1 | 10 | 4.8 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccco2)nc1 | 10.1021/jm0102304 | |||
10791823 | 9451 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)C(=O)CCC | 10.1021/jm970101g | |||
CHEMBL111783 | 9451 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)C(=O)CCC | 10.1021/jm970101g | |||
15289330 | 99856 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 493 | 8 | 1 | 8 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL285368 | 99856 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 493 | 8 | 1 | 8 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | |||
10361107 | 162142 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 359 | 5 | 2 | 5 | 4.1 | Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL416026 | 162142 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 359 | 5 | 2 | 5 | 4.1 | Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C | 10.1021/jm00008a013 | |||
44314658 | 207626 | None | 0 | Pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 589 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL78230 | 207626 | None | 0 | Pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 589 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
9951753 | 166432 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 379 | 7 | 1 | 5 | 4.7 | Cc1ccccc1C(Oc1cc(OCc2ccsc2)ccc1C#N)C(=O)O | 10.1021/jm990378b | |||
CHEMBL427294 | 166432 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 379 | 7 | 1 | 5 | 4.7 | Cc1ccccc1C(Oc1cc(OCc2ccsc2)ccc1C#N)C(=O)O | 10.1021/jm990378b | |||
11797717 | 209519 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 448 | 10 | 2 | 5 | 6.0 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc[nH]n1 | 10.1021/jm9707131 | |||
CHEMBL91753 | 209519 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 448 | 10 | 2 | 5 | 6.0 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc[nH]n1 | 10.1021/jm9707131 | |||
10668808 | 209619 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 402 | 9 | 1 | 5 | 4.8 | Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccncc2)ccc1C#N | 10.1021/jm9707131 | |||
CHEMBL92353 | 209619 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 402 | 9 | 1 | 5 | 4.8 | Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccncc2)ccc1C#N | 10.1021/jm9707131 | |||
10694804 | 210279 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 449 | 10 | 1 | 6 | 6.3 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ncco1 | 10.1021/jm9707131 | |||
CHEMBL96301 | 210279 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 449 | 10 | 1 | 6 | 6.3 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ncco1 | 10.1021/jm9707131 | |||
10695071 | 101212 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 454 | 6 | 1 | 6 | 4.3 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9700068 | |||
CHEMBL295477 | 101212 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 454 | 6 | 1 | 6 | 4.3 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9700068 | |||
10672494 | 179659 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 483 | 6 | 2 | 6 | 5.0 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)C)cc2)c1Br | 10.1021/jm9608366 | |||
CHEMBL47417 | 179659 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 483 | 6 | 2 | 6 | 5.0 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)C)cc2)c1Br | 10.1021/jm9608366 | |||
44327412 | 210040 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 497 | 5 | 1 | 8 | 3.0 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | |||
CHEMBL94929 | 210040 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 497 | 5 | 1 | 8 | 3.0 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | |||
CHEMBL343062 | 214155 | None | 0 | Pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
443289 | 711 | None | 39 | Human | Binding | pIC50 | = | 7.7 | 7.7 | 2 | 3 | ChEMBL | None | None | None | None | 10.1021/jm3009103 | |||||
997 | 711 | None | 39 | Human | Binding | pIC50 | = | 7.7 | 7.7 | 2 | 3 | ChEMBL | None | None | None | None | 10.1021/jm3009103 | |||||
CHEMBL314691 | 711 | None | 39 | Human | Binding | pIC50 | = | 7.7 | 7.7 | 2 | 3 | ChEMBL | None | None | None | None | 10.1021/jm3009103 | |||||
DB12054 | 711 | None | 39 | Human | Binding | pIC50 | = | 7.7 | 7.7 | 2 | 3 | ChEMBL | None | None | None | None | 10.1021/jm3009103 | |||||
44320431 | 107012 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 526 | 9 | 2 | 7 | 4.9 | O=C(O)COC1CCCCC1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | |||
CHEMBL314973 | 107012 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 526 | 9 | 2 | 7 | 4.9 | O=C(O)COC1CCCCC1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | |||
10767442 | 131291 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 492 | 8 | 1 | 5 | 6.1 | COc1ccc(C(=O)/C(Cc2ccc(-c3ccccc3)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm031041j | |||
CHEMBL368668 | 131291 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 492 | 8 | 1 | 5 | 6.1 | COc1ccc(C(=O)/C(Cc2ccc(-c3ccccc3)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm031041j | |||
CHEMBL313984 | 213582 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | |||||
CHEMBL265116 | 213094 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | |||||
10815005 | 9750 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 492 | 6 | 1 | 6 | 5.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(-c3ccccc3)cc2)cc1 | 10.1021/jm9606507 | |||
CHEMBL11345 | 9750 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 492 | 6 | 1 | 6 | 5.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(-c3ccccc3)cc2)cc1 | 10.1021/jm9606507 | |||
10506430 | 113854 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 532 | 9 | 2 | 7 | 4.5 | CCc1cccc(OC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | |||
CHEMBL332387 | 113854 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 532 | 9 | 2 | 7 | 4.5 | CCc1cccc(OC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | |||
10669001 | 112685 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 405 | 6 | 1 | 6 | 4.6 | N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccc2c(c1)OCO2 | 10.1021/jm970847e | |||
CHEMBL330255 | 112685 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 405 | 6 | 1 | 6 | 4.6 | N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccc2c(c1)OCO2 | 10.1021/jm970847e | |||
10692108 | 168273 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 395 | 6 | 1 | 4 | 5.5 | N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccccc1Cl | 10.1021/jm970847e | |||
CHEMBL433201 | 168273 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 395 | 6 | 1 | 4 | 5.5 | N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccccc1Cl | 10.1021/jm970847e | |||
CHEMBL313984 | 213582 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | |||||
10577255 | 175523 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 497 | 8 | 2 | 6 | 5.2 | CCCCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | |||
CHEMBL45760 | 175523 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 497 | 8 | 2 | 6 | 5.2 | CCCCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | |||
CHEMBL1793926 | 211389 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm970161m | |||||
10769045 | 131285 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 551 | 10 | 4 | 6 | 5.0 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2(C)CCCCC2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL368641 | 131285 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 551 | 10 | 4 | 6 | 5.0 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2(C)CCCCC2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL134562 | 211189 | None | 0 | Pig | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL436899 | 216155 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | |||||
CHEMBL407933 | 215154 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
18617284 | 207666 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 350 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | |||
CHEMBL78552 | 207666 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 350 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | |||
44314579 | 102972 | None | 0 | Pig | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL306123 | 102972 | None | 0 | Pig | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1021/jm9600914 | |||
10549516 | 110446 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 410 | 8 | 1 | 4 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2ccccc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
CHEMBL324301 | 110446 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 410 | 8 | 1 | 4 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2ccccc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | |||
22010208 | 209553 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 362 | 9 | 1 | 3 | 5.3 | O=C(O)CCC(Oc1cccc(OCc2ccccc2)c1)c1ccccc1 | 10.1021/jm970847e | |||
CHEMBL91965 | 209553 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 362 | 9 | 1 | 3 | 5.3 | O=C(O)CCC(Oc1cccc(OCc2ccccc2)c1)c1ccccc1 | 10.1021/jm970847e | |||
10717670 | 209653 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 433 | 7 | 1 | 5 | 5.7 | O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1c(F)cccc1Cl | 10.1021/jm970847e | |||
CHEMBL92570 | 209653 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 433 | 7 | 1 | 5 | 5.7 | O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1c(F)cccc1Cl | 10.1021/jm970847e | |||
19735404 | 175925 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 471 | 9 | 2 | 7 | 3.5 | COc1ccccc1Cc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL4584753 | 175925 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 471 | 9 | 2 | 7 | 3.5 | COc1ccccc1Cc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO | 10.1016/j.bmcl.2016.06.014 | |||
10528383 | 11239 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 470 | 5 | 1 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | |||
CHEMBL1178854 | 11239 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 470 | 5 | 1 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | |||
CHEMBL46357 | 11239 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 470 | 5 | 1 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | |||
10604797 | 102399 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 704 | 14 | 1 | 13 | 3.3 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OCCN3CCOCC3)c(OC)c(OCCN3CCOCC3)c2)cc1 | 10.1021/jm980504w | |||
CHEMBL303712 | 102399 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 704 | 14 | 1 | 13 | 3.3 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OCCN3CCOCC3)c(OC)c(OCCN3CCOCC3)c2)cc1 | 10.1021/jm980504w | |||
10238141 | 198307 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 429 | 5 | 1 | 6 | 4.2 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2ccccc21 | 10.1016/S0960-894X(97)00319-3 | |||
CHEMBL55853 | 198307 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 429 | 5 | 1 | 6 | 4.2 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2ccccc21 | 10.1016/S0960-894X(97)00319-3 | |||
44283270 | 167984 | None | 0 | Pig | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1016/0960-894X(95)00237-N | |||
CHEMBL431124 | 167984 | None | 0 | Pig | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1016/0960-894X(95)00237-N | |||
10357554 | 97617 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 302 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C | 10.1021/jm00029a001 | |||
CHEMBL27065 | 97617 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 302 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C | 10.1021/jm00029a001 | |||
44278161 | 99858 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 569 | 10 | 1 | 8 | 6.9 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | |||
CHEMBL285380 | 99858 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 569 | 10 | 1 | 8 | 6.9 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | |||
10357554 | 97617 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 302 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C | 10.1021/jm00008a013 | |||
CHEMBL27065 | 97617 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 302 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C | 10.1021/jm00008a013 | |||
10495634 | 210387 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 316 | 6 | 1 | 2 | 4.8 | OC/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 | 10.1021/jm970847e | |||
CHEMBL96836 | 210387 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 316 | 6 | 1 | 2 | 4.8 | OC/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 | 10.1021/jm970847e | |||
44276966 | 106912 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 352 | 5 | 1 | 5 | 2.9 | COc1cccc(Cn2[nH]c(C)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144846 | 106912 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 352 | 5 | 1 | 5 | 2.9 | COc1cccc(Cn2[nH]c(C)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | |||
44386894 | 62501 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 412 | 7 | 2 | 6 | 2.1 | COc1ccc([C@@H]2[C@@H](CC(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 | 10.1021/jm031041j | |||
CHEMBL177999 | 62501 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 412 | 7 | 2 | 6 | 2.1 | COc1ccc([C@@H]2[C@@H](CC(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 | 10.1021/jm031041j | |||
11795139 | 166632 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 398 | 6 | 2 | 6 | 1.8 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 | 10.1021/jm9505369 | |||
CHEMBL427935 | 166632 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 398 | 6 | 2 | 6 | 1.8 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 | 10.1021/jm9505369 | |||
10212163 | 130164 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 696 | 11 | 2 | 13 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL367767 | 130164 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 696 | 11 | 2 | 13 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | |||
23445256 | 60209 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 470 | 6 | 1 | 7 | 4.1 | Cc1noc(NS(=O)(=O)c2ccsc2CCc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | |||
CHEMBL173982 | 60209 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 470 | 6 | 1 | 7 | 4.1 | Cc1noc(NS(=O)(=O)c2ccsc2CCc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | |||
10604119 | 11461 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 636 | 12 | 2 | 7 | 5.8 | COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | |||
CHEMBL1180361 | 11461 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 636 | 12 | 2 | 7 | 5.8 | COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | |||
CHEMBL123654 | 11461 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 636 | 12 | 2 | 7 | 5.8 | COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | |||
44325305 | 209926 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 426 | 10 | 2 | 5 | 5.3 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(=O)O | 10.1021/jm9707131 | |||
CHEMBL94279 | 209926 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 426 | 10 | 2 | 5 | 5.3 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(=O)O | 10.1021/jm9707131 | |||
10005597 | 119882 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 | 10.1021/jm031041j | |||
CHEMBL348407 | 119882 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 | 10.1021/jm031041j | |||
10005597 | 119882 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | |||
CHEMBL348407 | 119882 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | |||
CHEMBL433349 | 216098 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
44314890 | 105132 | None | 0 | Pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 647 | 12 | 5 | 4 | 5.0 | CC(C)CC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
CHEMBL311384 | 105132 | None | 0 | Pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 647 | 12 | 5 | 4 | 5.0 | CC(C)CC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | |||
3539 | 4141 | None | 55 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 424 | 6 | 1 | 9 | 2.7 | COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 | 10.1016/j.bmcl.2016.06.014 | |||
9910224 | 4141 | None | 55 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 424 | 6 | 1 | 9 | 2.7 | COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 | 10.1016/j.bmcl.2016.06.014 | |||
9910224.0 | 4141 | None | 55 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 424 | 6 | 1 | 9 | 2.7 | COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 | 10.1016/j.bmcl.2016.06.014 | |||
CHEMBL1628688 | 4141 | None | 55 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 424 | 6 | 1 | 9 | 2.7 | COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 | 10.1016/j.bmcl.2016.06.014 | |||
DB06629 | 4141 | None | 55 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 424 | 6 | 1 | 9 | 2.7 | COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 | 10.1016/j.bmcl.2016.06.014 | |||
10168597 | 61357 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 | 10.1016/s0960-894x(02)01084-3 | |||
CHEMBL176741 | 61357 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 | 10.1016/s0960-894x(02)01084-3 | |||
10673969 | 62125 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 538 | 10 | 3 | 7 | 5.0 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | |||
CHEMBL177546 | 62125 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 538 | 10 | 3 | 7 | 5.0 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | |||
10138169 | 99415 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl | 10.1021/jm000349x | |||
CHEMBL282470 | 99415 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl | 10.1021/jm000349x | |||
CHEMBL342615 | 214134 | None | 0 | Pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
CHEMBL342615 | 214134 | None | 0 | Pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
10527706 | 97054 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 454 | 8 | 1 | 6 | 3.1 | CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
CHEMBL266594 | 97054 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 454 | 8 | 1 | 6 | 3.1 | CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | |||
44439114 | 161724 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 993 | 32 | 2 | 15 | 7.3 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CCC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 | 10.1016/j.bmcl.2006.10.009 | |||
CHEMBL413001 | 161724 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 993 | 32 | 2 | 15 | 7.3 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CCC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 | 10.1016/j.bmcl.2006.10.009 | |||
18738889 | 88000 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 562 | 8 | 1 | 8 | 4.9 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)OC)cc21 | 10.1016/s0960-894x(01)00660-6 | |||
CHEMBL23418 | 88000 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 562 | 8 | 1 | 8 | 4.9 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)OC)cc21 | 10.1016/s0960-894x(01)00660-6 | |||
10310877 | 206347 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 473 | 8 | 1 | 7 | 5.9 | CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1ccc2nsnc2c1 | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL68896 | 206347 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 473 | 8 | 1 | 7 | 5.9 | CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1ccc2nsnc2c1 | 10.1016/s0960-894x(97)10151-2 | |||
CHEMBL136210 | 211196 | None | 0 | Pig | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | |||||
21462927 | 120306 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 500 | 7 | 1 | 8 | 5.1 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc([N+](=O)[O-])ccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | |||
CHEMBL352241 | 120306 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 500 | 7 | 1 | 8 | 5.1 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc([N+](=O)[O-])ccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | |||
10086660 | 99214 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 309 | 6 | 2 | 5 | 2.9 | CCCNc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1 | 10.1021/jm00008a013 | |||
CHEMBL281199 | 99214 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 309 | 6 | 2 | 5 | 2.9 | CCCNc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1 | 10.1021/jm00008a013 | |||
44279308 | 100187 | None | 0 | Pig | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 521 | 12 | 6 | 4 | 3.3 | Cc1cccc(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCC(=O)O)c1 | 10.1016/0960-894X(95)00221-E | |||
CHEMBL287676 | 100187 | None | 0 | Pig | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 521 | 12 | 6 | 4 | 3.3 | Cc1cccc(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCC(=O)O)c1 | 10.1016/0960-894X(95)00221-E | |||
44279307 | 108070 | None | 0 | Pig | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 541 | 12 | 6 | 4 | 3.7 | CC(C)C[C@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O | 10.1016/0960-894X(95)00221-E | |||
CHEMBL31944 | 108070 | None | 0 | Pig | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 541 | 12 | 6 | 4 | 3.7 | CC(C)C[C@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O | 10.1016/0960-894X(95)00221-E | |||
CHEMBL319537 | 213678 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | |||||
10621049 | 209701 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 400 | 6 | 1 | 3 | 5.6 | OC/C(=C/c1cc(OCc2ccsc2)ccc1Br)c1ccccc1 | 10.1021/jm970847e | |||
CHEMBL92876 | 209701 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 400 | 6 | 1 | 3 | 5.6 | OC/C(=C/c1cc(OCc2ccsc2)ccc1Br)c1ccccc1 | 10.1021/jm970847e | |||
44213278 | 106905 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)cc1 | 10.1016/s0960-894x(00)00232-8 | |||
CHEMBL3144799 | 106905 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)cc1 | 10.1016/s0960-894x(00)00232-8 | |||
10719007 | 11245 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 465 | 6 | 1 | 9 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | |||
CHEMBL1178895 | 11245 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 465 | 6 | 1 | 9 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | |||
CHEMBL48448 | 11245 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 465 | 6 | 1 | 9 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | |||
10626054 | 131416 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 530 | 11 | 6 | 4 | 4.2 | Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL368788 | 131416 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 530 | 11 | 6 | 4 | 4.2 | Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O | 10.1021/jm950592+ | |||
CHEMBL1206645 | 211067 | None | 0 | Pig | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm00087a001 | |||||
CHEMBL290454 | 211067 | None | 0 | Pig | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm00087a001 | |||||
10742968 | 12365 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 469 | 7 | 1 | 8 | 4.1 | Cc1noc(NS(=O)(=O)c2ccsc2C(Cc2ccc3c(c2)OCO3)N(C)C)c1Cl | 10.1021/jm9700068 | |||
CHEMBL1185472 | 12365 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 469 | 7 | 1 | 8 | 4.1 | Cc1noc(NS(=O)(=O)c2ccsc2C(Cc2ccc3c(c2)OCO3)N(C)C)c1Cl | 10.1021/jm9700068 | |||
CHEMBL416453 | 12365 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 469 | 7 | 1 | 8 | 4.1 | Cc1noc(NS(=O)(=O)c2ccsc2C(Cc2ccc3c(c2)OCO3)N(C)C)c1Cl | 10.1021/jm9700068 | |||
44368481 | 121584 | None | 0 | Pig | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 435 | 9 | 2 | 7 | 2.8 | CCOC(=O)CN(Cc1cc2c(cc1Cl)OCO2)C(Cc1ccc(O)cc1)C(=O)O | 10.1016/s0960-894x(01)00009-9 | |||
CHEMBL358444 | 121584 | None | 0 | Pig | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 435 | 9 | 2 | 7 | 2.8 | CCOC(=O)CN(Cc1cc2c(cc1Cl)OCO2)C(Cc1ccc(O)cc1)C(=O)O | 10.1016/s0960-894x(01)00009-9 | |||
10576888 | 170948 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 485 | 6 | 3 | 7 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2C(=O)O)c1Br | 10.1021/jm9608366 | |||
CHEMBL44539 | 170948 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 485 | 6 | 3 | 7 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2C(=O)O)c1Br | 10.1021/jm9608366 | |||
23445284 | 112865 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 440 | 5 | 1 | 5 | 5.4 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(C(C)C)cc2)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
CHEMBL330674 | 112865 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 440 | 5 | 1 | 5 | 5.4 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(C(C)C)cc2)c1Br | 10.1016/S0960-894X(96)00496-9 | |||
23445458 | 60320 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 468 | 5 | 1 | 7 | 4.5 | Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | |||
CHEMBL174363 | 60320 | None | 0 | Human | Binding | pIC50 | = | 6.7 |