Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44263999	200646	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL	558	15	5	6	3.3	COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)O)cc1	10.1021/jm950908d
	CHEMBL7753	200646	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL	558	15	5	6	3.3	COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)O)cc1	10.1021/jm950908d
	CHEMBL267388	206221	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL		None	None	None		CSCC[C@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	1022	1559	44	None	4897	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL		None	None	None		None	10.1021/jm900592h
	443295	1559	44	None	4897	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL		None	None	None		None	10.1021/jm900592h
	CHEMBL267179	1559	44	None	4897	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL		None	None	None		None	10.1021/jm900592h
	145952664	161630	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	500	9	3	4	4.6	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4166385	161630	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	500	9	3	4	4.6	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	71698968	90034	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	445	5	1	4	4.2	Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391281	90034	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	445	5	1	4	4.2	Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	44232677	191934	0	None	1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	408	7	1	7	2.7	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL562456	191934	0	None	1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	408	7	1	7	2.7	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1	10.1021/jm900592h
	71698530	90029	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	509	7	1	5	5.3	COc1cccc(Cc2cc(C3CCCCC3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391257	90029	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	509	7	1	5	5.3	COc1cccc(Cc2cc(C3CCCCC3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	44233646	192011	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562910	192011	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	44233646	192011	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562910	192011	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	71698446	90066	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	427	5	1	5	3.6	COc1ccc(-c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391452	90066	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	427	5	1	5	3.6	COc1ccc(-c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2013.03.066
	44232924	190915	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551590	190915	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	44232924	190915	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551590	190915	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	122487974	169597	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	497	9	1	5	5.3	CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4448213	169597	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	497	9	1	5	5.3	CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O	10.1021/acs.jmedchem.8b01912
	71699142	90063	0	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	442	6	2	6	3.7	COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391449	90063	0	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	442	6	2	6	3.7	COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2013.03.066
	71698365	90061	0	None	-7	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	484	7	2	7	3.9	COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391447	90061	0	None	-7	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	484	7	2	7	3.9	COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2013.03.066
	71699061	90054	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	461	5	1	4	4.7	Cc1cc(Cc2cccc3ccccc23)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391438	90054	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	461	5	1	4	4.7	Cc1cc(Cc2cccc3ccccc23)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	145949892	162017	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4172556	162017	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	155519369	169561	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	441	7	1	6	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1OC	10.1021/acs.jmedchem.8b01912
	CHEMBL4447830	169561	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	441	7	1	6	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1OC	10.1021/acs.jmedchem.8b01912
	44233647	191124	0	None	-1	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	CHEMBL554291	191124	0	None	-1	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	54580795	60957	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assayAgonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	424	8	2	6	4.6	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770476	60957	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assayAgonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	424	8	2	6	4.6	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	44236330	190424	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL539401	190424	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	44236330	190424	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL539401	190424	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	155516247	169213	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	411	6	1	5	4.0	COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Cl)cc2)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4442702	169213	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	411	6	1	5	4.0	COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Cl)cc2)c1=O	10.1021/acs.jmedchem.8b01912
	145953127	161636	0	None	-9	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	470	8	4	2	4.9	O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4166447	161636	0	None	-9	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	470	8	4	2	4.9	O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL266802	206203	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL		None	None	None		CSCC[C@H](NC(=O)Nc1ccc(C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	1022	1559	44	None	4897	3	Human	7.7	pEC50	=	7.7	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL		None	None	None		None	10.1021/jm950908d
	443295	1559	44	None	4897	3	Human	7.7	pEC50	=	7.7	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL		None	None	None		None	10.1021/jm950908d
	CHEMBL267179	1559	44	None	4897	3	Human	7.7	pEC50	=	7.7	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL		None	None	None		None	10.1021/jm950908d
	44233648	190659	0	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL549570	190659	0	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	44233648	190659	0	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL549570	190659	0	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	155519289	169548	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	427	7	1	6	3.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1OC	10.1021/acs.jmedchem.8b01912
	CHEMBL4447632	169548	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	427	7	1	6	3.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1OC	10.1021/acs.jmedchem.8b01912
	44232675	191252	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1	10.1021/jm900592h
	CHEMBL556485	191252	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1	10.1021/jm900592h
	145978177	162258	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	452	8	4	2	4.7	O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4176353	162258	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	452	8	4	2	4.7	O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	122487986	175153	0	None	1	2	Human	4.6	pEC50	=	4.6	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	411	6	1	5	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/acs.jmedchem.8b01912
	CHEMBL4588649	175153	0	None	1	2	Human	4.6	pEC50	=	4.6	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	411	6	1	5	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/acs.jmedchem.8b01912
	122181231	120958	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL3588871	120958	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.ejmech.2017.09.023
	44236328	191265	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL556625	191265	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	44236326	190914	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551589	190914	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	44236326	190914	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551589	190914	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	44233644	191678	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL560780	191678	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	145952485	162050	0	None	-2	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4172968	162050	0	None	-2	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	155538591	171590	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	427	7	1	6	3.5	COc1cccc(OC)c1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4476616	171590	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	427	7	1	6	3.5	COc1cccc(OC)c1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O	10.1021/acs.jmedchem.8b01912
	71699063	90057	0	None	-1	2	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	454	6	2	5	2.6	Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391440	90057	0	None	-1	2	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	454	6	2	5	2.6	Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL265408	206150	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL		None	None	None		CCCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	71698362	90060	0	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	455	6	1	6	3.2	COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391446	90060	0	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	455	6	1	6	3.2	COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL7306	209953	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL		None	None	None		CSCC[C@H](NC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	24776341	3055	28	None	-20	4	Human	7.5	pEC50	=	7.5	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.8b01912
	5831	3055	28	None	-20	4	Human	7.5	pEC50	=	7.5	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.8b01912
	CHEMBL379761	3055	28	None	-20	4	Human	7.5	pEC50	=	7.5	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.8b01912
	44232925	192236	2	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL564392	192236	2	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	44233644	191678	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL560780	191678	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	44233645	191773	0	None	-5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	363	6	1	5	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1	10.1021/jm900592h
	CHEMBL561375	191773	0	None	-5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	363	6	1	5	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1	10.1021/jm900592h
	44233644	191678	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL560780	191678	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	44233645	191773	0	None	-5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	363	6	1	5	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1	10.1021/jm900592h
	CHEMBL561375	191773	0	None	-5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	363	6	1	5	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1	10.1021/jm900592h
	44236326	190914	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551589	190914	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	44233647	191124	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	CHEMBL554291	191124	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	44232675	191252	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1	10.1021/jm900592h
	CHEMBL556485	191252	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1	10.1021/jm900592h
	44233647	191124	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	CHEMBL554291	191124	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	44232675	191252	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1	10.1021/jm900592h
	CHEMBL556485	191252	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1	10.1021/jm900592h
	44236329	191038	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL552396	191038	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1	10.1021/jm900592h
	44236329	191038	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL552396	191038	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL7520	209956	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL		None	None	None		CSCC[C@H](NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	11024	656	6	None	-794	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	122583088	656	6	None	-794	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4784510	656	6	None	-794	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	71698528	90027	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	503	7	1	5	3.6	CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391255	90027	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	503	7	1	5	3.6	CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1	10.1016/j.ejmech.2013.03.066
	122181231	120958	0	None	-3	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3588871	120958	0	None	-3	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	44233905	191921	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562380	191921	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1021/jm900592h
	44233905	191921	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562380	191921	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1021/jm900592h
	145956361	161208	0	None	2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4159569	161208	0	None	2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	71698529	90028	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	469	7	1	5	4.4	COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391256	90028	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	469	7	1	5	4.4	COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	71699059	90036	0	None	3	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	417	5	1	5	3.6	Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391286	90036	0	None	3	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	417	5	1	5	3.6	Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	145956762	161366	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4162303	161366	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	457933	209804	18	None	-501	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C	10.1021/jm900592h
	CHEMBL552527	209804	18	None	-501	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C	10.1021/jm900592h
	11024	656	6	None	-524	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	122583088	656	6	None	-524	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4784510	656	6	None	-524	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	145958736	161414	0	None	-6	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4162930	161414	0	None	-6	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	155555898	173548	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4551649	173548	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O	10.1021/acs.jmedchem.8b01912
	146035589	172909	0	None	-1	2	Human	7.3	pEC50	=	7.3	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	483	10	1	6	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4536334	172909	0	None	-1	2	Human	7.3	pEC50	=	7.3	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	483	10	1	6	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O	10.1021/acs.jmedchem.8b01912
	145951856	162088	0	None	-8	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4173645	162088	0	None	-8	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	71698880	90031	0	None	2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	411	5	1	4	3.5	Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391277	90031	0	None	2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	411	5	1	4	3.5	Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	44233648	190659	0	None	-2	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL549570	190659	0	None	-2	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	71698972	90035	0	None	1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	401	5	1	5	3.1	Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391285	90035	0	None	1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	401	5	1	5	3.1	Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	145955803	161843	0	None	-2	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	488	8	3	3	4.7	Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F	10.1016/j.ejmech.2017.09.023
	CHEMBL4169807	161843	0	None	-2	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	488	8	3	3	4.7	Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F	10.1016/j.ejmech.2017.09.023
	154706263	172749	2	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	527	10	1	6	5.3	CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4532583	172749	2	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	527	10	1	6	5.3	CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O	10.1021/acs.jmedchem.8b01912
	146035588	170080	2	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4454594	170080	2	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O	10.1021/acs.jmedchem.8b01912
	71698527	90026	0	None	1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	427	6	1	5	3.2	COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391254	90026	0	None	1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	427	6	1	5	3.2	COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	145956276	161873	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4170201	161873	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	122488043	173446	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	427	7	1	6	3.5	COc1ccc(OC)c(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/acs.jmedchem.8b01912
	CHEMBL4549250	173446	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	427	7	1	6	3.5	COc1ccc(OC)c(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/acs.jmedchem.8b01912
	71698967	90033	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	429	5	1	4	3.7	Cc1cc(Cc2cccc(F)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391280	90033	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	429	5	1	4	3.7	Cc1cc(Cc2cccc(F)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	44236328	191265	0	None	-1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL556625	191265	0	None	-1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	44236328	191265	0	None	-1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL556625	191265	0	None	-1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	71698966	90032	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	377	5	1	6	2.5	Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc3c(c2)OCO3)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391279	90032	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	377	5	1	6	2.5	Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc3c(c2)OCO3)n1	10.1016/j.ejmech.2013.03.066
	44236330	190424	0	None	-1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL539401	190424	0	None	-1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	71699065	90058	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	519	7	1	6	3.4	COc1cc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)cc(OC)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391442	90058	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	519	7	1	6	3.4	COc1cc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)cc(OC)c1	10.1016/j.ejmech.2013.03.066
	44236329	191038	0	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL552396	191038	0	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1	10.1021/jm900592h
	44233646	192011	0	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562910	192011	0	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	44232925	192236	2	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL564392	192236	2	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	44232925	192236	2	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL564392	192236	2	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	ChEMBL	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	71699060	90053	0	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	417	5	1	5	3.6	Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391437	90053	0	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	417	5	1	5	3.6	Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	71698442	90062	0	None	3	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	336	3	2	5	1.5	Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391448	90062	0	None	3	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	336	3	2	5	1.5	Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	145963525	161520	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4164673	161520	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	146035588	170080	2	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4454594	170080	2	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL6997	209947	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	ChEMBL		None	None	None		CSCC[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	71698531	90030	0	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	503	7	1	5	4.9	COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391258	90030	0	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	503	7	1	5	4.9	COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	71699062	90055	0	None	-3	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	412	5	1	5	2.9	Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391439	90055	0	None	-3	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	412	5	1	5	2.9	Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	71699143	90065	0	None	-3	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	470	6	2	6	3.2	COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391450	90065	0	None	-3	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	470	6	2	6	3.2	COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	145954612	161767	0	None	-2	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	482	9	4	3	4.8	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4168567	161767	0	None	-2	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	482	9	4	3	4.8	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	122181322	121114	0	None	-1	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590073	121114	0	None	-1	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	71699139	90059	0	None	1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	493	5	1	4	4.0	Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391443	90059	0	None	1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	493	5	1	4	4.0	Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1	10.1016/j.ejmech.2013.03.066
	44232924	190915	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551590	190915	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	155555363	173555	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	439	8	1	5	4.8	CCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4551842	173555	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	439	8	1	5	4.8	CCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL1628710	55792	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.049
	CHEMBL6450	209935	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	57399909	67745	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	452	6	2	5	4.3	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916276	67745	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	452	6	2	5	4.3	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	57398259	67754	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	446	6	2	5	4.4	Cc1nn(-c2ccccc2)c(NS(=O)(=O)C2CCCCC2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.08.085
	CHEMBL1916286	67754	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	446	6	2	5	4.4	Cc1nn(-c2ccccc2)c(NS(=O)(=O)C2CCCCC2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.08.085
	57394708	67755	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	459	6	2	6	3.7	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2cccnc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.08.085
	CHEMBL1916287	67755	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	459	6	2	6	3.7	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2cccnc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.08.085
	57396213	69029	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	420	6	2	5	4.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)C)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934267	69029	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	420	6	2	5	4.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)C)cc1	10.1016/j.bmcl.2011.10.090
	57390868	69053	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	448	6	2	6	3.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOC2)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934423	69053	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	448	6	2	6	3.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOC2)cc1	10.1016/j.bmcl.2011.10.090
	54580795	60957	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	424	8	2	6	4.6	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770476	60957	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	424	8	2	6	4.6	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	54580798	60963	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	391	7	2	4	5.3	CCC[C@H](NC(=O)c1oc2ccc(OCC)cc2c1C)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770484	60963	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	391	7	2	4	5.3	CCC[C@H](NC(=O)c1oc2ccc(OCC)cc2c1C)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	2528	3491	78	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.049
	5342	3491	78	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.049
	5826	3491	78	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.049
	CHEMBL832	3491	78	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.049
	DB01138	3491	78	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.049
	57394598	67709	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	446	7	2	5	3.9	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccccc3)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916086	67709	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	446	7	2	5	3.9	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccccc3)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	57401587	67726	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	440	6	2	6	2.9	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916257	67726	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	440	6	2	6	2.9	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	57394706	67732	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	426	8	2	5	3.9	CCC(CC)NC(=O)c1cn(-c2ccccc2)nc1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916263	67732	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	426	8	2	5	3.9	CCC(CC)NC(=O)c1cn(-c2ccccc2)nc1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	57401680	67733	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	460	8	2	5	4.6	CCC(CC)NC(=O)c1cnn(-c2ccccc2Cl)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916264	67733	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	460	8	2	5	4.6	CCC(CC)NC(=O)c1cnn(-c2ccccc2Cl)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	57403415	67737	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	392	8	2	5	3.5	CCC(CC)NC(=O)c1cnn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916268	67737	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	392	8	2	5	3.5	CCC(CC)NC(=O)c1cnn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	57397970	69049	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	510	6	2	7	3.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCS(=O)(=O)CC2)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934419	69049	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	510	6	2	7	3.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCS(=O)(=O)CC2)cc1	10.1016/j.bmcl.2011.10.090
	54586641	60895	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	388	5	2	3	4.5	Cc1cccc(C)c1NC(=O)C(c1ccccc1)N(C)C(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	CHEMBL1770308	60895	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	388	5	2	3	4.5	Cc1cccc(C)c1NC(=O)C(c1ccccc1)N(C)C(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	24244526	60951	4	None	-	1	Human	5.0	pIC50	=	5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	327	6	2	5	2.6	CSCCC(NC(=O)c1cnccn1)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770469	60951	4	None	-	1	Human	5.0	pIC50	=	5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	327	6	2	5	2.6	CSCCC(NC(=O)c1cnccn1)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	54583762	60952	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	330	6	2	5	3.1	CSCCC(NC(=O)c1ocnc1C)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770470	60952	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	330	6	2	5	3.1	CSCCC(NC(=O)c1ocnc1C)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	5126271	60954	1	None	-	1	Human	5.0	pIC50	=	5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	339	6	2	3	4.1	CSCCC(NC(=O)c1ccc(C)cc1)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770472	60954	1	None	-	1	Human	5.0	pIC50	=	5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	339	6	2	3	4.1	CSCCC(NC(=O)c1ccc(C)cc1)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	54582778	60962	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	441	7	2	6	3.5	CCOc1ccc2oc(C(=O)NC(CS(C)(=O)=O)c3nc4ccccc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770482	60962	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	441	7	2	6	3.5	CCOc1ccc2oc(C(=O)NC(CS(C)(=O)=O)c3nc4ccccc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	155517073	169346	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4444413	169346	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	155529906	170657	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	421	8	3	4	2.8	COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C	10.1039/C9MD00336C
	CHEMBL4463562	170657	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	421	8	3	4	2.8	COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C	10.1039/C9MD00336C
	57398260	67757	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	526	6	2	5	5.3	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.08.085
	CHEMBL1916289	67757	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	526	6	2	5	5.3	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.08.085
	71698276	172979	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	475	9	3	4	4.1	COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4538076	172979	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	475	9	3	4	4.1	COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	57398258	67750	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916281	67750	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	3089940	60871	2	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	374	5	3	3	4.1	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccccc1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770153	60871	2	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	374	5	3	3	4.1	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccccc1	10.1016/j.bmcl.2011.03.049
	92263206	173353	0	None	-1	2	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	465	8	3	5	3.5	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C	10.1039/C9MD00336C
	CHEMBL4547265	173353	0	None	-1	2	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	465	8	3	5	3.5	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C	10.1039/C9MD00336C
	118707168	112308	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	893	22	6	8	6.6	CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311300	112308	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	893	22	6	8	6.6	CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	155524563	170109	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	435	9	3	4	3.2	COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4455225	170109	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	435	9	3	4	3.2	COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	4329947	2362	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	5829	2362	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	CHEMBL1770297	2362	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	57392963	67746	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	466	6	2	5	4.6	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916277	67746	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	466	6	2	5	4.6	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	57399910	67749	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	426	7	2	5	3.8	CCC(C)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916280	67749	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	426	7	2	5	3.8	CCC(C)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	56949966	69055	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	488	7	2	6	4.4	Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.10.090
	CHEMBL1934426	69055	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	488	7	2	6	4.4	Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.10.090
	53233899	1324	0	None	69	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	5830	1324	0	None	69	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	CHEMBL1770298	1324	0	None	69	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	57392872	67708	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	452	6	1	5	4.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916085	67708	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	452	6	1	5	4.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	57399908	67731	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	426	8	2	5	3.9	CCC(CC)NC(=O)c1ncn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916262	67731	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	426	8	2	5	3.9	CCC(CC)NC(=O)c1ncn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	57399672	69032	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	434	5	2	5	4.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)(C)C)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934270	69032	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	434	5	2	5	4.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)(C)C)cc1	10.1016/j.bmcl.2011.10.090
	54581781	60890	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	378	5	3	5	2.9	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1cn(C)cn1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770301	60890	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	378	5	3	5	2.9	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1cn(C)cn1	10.1016/j.bmcl.2011.03.049
	57396467	67734	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	451	8	2	6	3.8	CCC(CC)NC(=O)c1cnn(-c2ccc(C#N)cc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916265	67734	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	451	8	2	6	3.8	CCC(CC)NC(=O)c1cnn(-c2ccc(C#N)cc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL6997	209947	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CSCC[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	117993763	170789	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4465341	170789	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	92263206	173353	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	465	8	3	5	3.5	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C	10.1039/C9MD00336C
	CHEMBL4547265	173353	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	465	8	3	5	3.5	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C	10.1039/C9MD00336C
	71697968	173752	15	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4556626	173752	15	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	155510570	173211	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	449	10	3	4	3.1	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1039/C9MD00336C
	CHEMBL4543372	173211	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	449	10	3	4	3.1	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1039/C9MD00336C
	57401368	69043	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	432	6	2	5	4.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCC2)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934413	69043	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	432	6	2	5	4.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCC2)cc1	10.1016/j.bmcl.2011.10.090
	57399796	67706	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	426	8	2	5	3.9	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916082	67706	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	426	8	2	5	3.9	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	57401684	67748	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	440	6	2	5	4.1	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCC(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916279	67748	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	440	6	2	5	4.1	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCC(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	54581826	60953	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	365	6	2	4	4.5	CSCCC(NC(=O)c1sccc1Cl)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770471	60953	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	365	6	2	4	4.5	CSCCC(NC(=O)c1sccc1Cl)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	57398252	67735	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	427	8	2	6	3.3	CCC(CC)NC(=O)c1cnn(-c2ccccn2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916266	67735	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	427	8	2	6	3.3	CCC(CC)NC(=O)c1cnn(-c2ccccn2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL7486	209955	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		Cc1cccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1	10.1021/jm950908d
	CHEMBL3311030	206840	17	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	10579232	199306	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL	586	14	5	5	3.7	CSCC[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	CHEMBL6779	199306	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL	586	14	5	5	3.7	CSCC[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	CHEMBL415299	208682	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CSCC[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	CHEMBL7181	209950	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	155517009	169339	0	None	3	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4444320	169339	0	None	3	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	155524563	170109	0	None	-1	2	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	435	9	3	4	3.2	COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4455225	170109	0	None	-1	2	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	435	9	3	4	3.2	COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	57403416	67753	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	508	6	2	5	5.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C(F)(F)F)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916284	67753	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	508	6	2	5	5.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C(F)(F)F)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	54752118	67756	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	483	6	2	6	4.2	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.08.085
	CHEMBL1916288	67756	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	483	6	2	6	4.2	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.08.085
	54752118	67756	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	483	6	2	6	4.2	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.10.090
	CHEMBL1916288	67756	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	483	6	2	6	4.2	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.10.090
	CHEMBL1770296	204398	23	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL		None	None	None		CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmcl.2011.03.049
	57401370	69046	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	450	8	2	6	3.7	COCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934416	69046	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	450	8	2	6	3.7	COCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.10.090
	4652862	47080	9	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	331	6	2	3	4.1	CSCCC(NC(=O)C1CCCCC1)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1545798	47080	9	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	331	6	2	3	4.1	CSCCC(NC(=O)C1CCCCC1)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	54587661	60893	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	386	5	3	3	4.0	O=C(NC(C(=O)NC1CCCCC1)c1ccc(Cl)cc1)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	CHEMBL1770304	60893	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	386	5	3	3	4.0	O=C(NC(C(=O)NC1CCCCC1)c1ccc(Cl)cc1)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	54586640	60894	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	460	5	3	4	4.3	Cc1cccc(C)c1NC(=O)C(NC(=O)c1nc2ccccc2[nH]c1=O)c1ccc(Cl)cc1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770307	60894	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	460	5	3	4	4.3	Cc1cccc(C)c1NC(=O)C(NC(=O)c1nc2ccccc2[nH]c1=O)c1ccc(Cl)cc1	10.1016/j.bmcl.2011.03.049
	3825824	60955	10	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	415	8	1	4	5.3	CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccccc1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770474	60955	10	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	415	8	1	4	5.3	CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccccc1	10.1016/j.bmcl.2011.03.049
	57403176	69028	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	406	8	2	5	3.8	CCC(CC)NC(=O)c1c(C)nn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934266	69028	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	406	8	2	5	3.8	CCC(CC)NC(=O)c1c(C)nn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.10.090
	53233899	1324	0	None	-69	2	Mouse	4.6	pIC50	=	4.6	Functional	Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	5830	1324	0	None	-69	2	Mouse	4.6	pIC50	=	4.6	Functional	Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	CHEMBL1770298	1324	0	None	-69	2	Mouse	4.6	pIC50	=	4.6	Functional	Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	155529906	170657	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	421	8	3	4	2.8	COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C	10.1039/C9MD00336C
	CHEMBL4463562	170657	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	421	8	3	4	2.8	COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C	10.1039/C9MD00336C
	155510570	173211	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	449	10	3	4	3.1	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1039/C9MD00336C
	CHEMBL4543372	173211	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	449	10	3	4	3.1	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1039/C9MD00336C
	CHEMBL1934424	69054	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	490	7	2	6	4.6	CO[C@H]1CC[C@@H](n2nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c2NS(=O)(=O)c2ccc(C)cc2)CC1	10.1016/j.bmcl.2011.10.090
	9988173	161112	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL	862	21	7	6	5.5	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	CHEMBL415296	161112	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL	862	21	7	6	5.5	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	CHEMBL266448	206187	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	CHEMBL7214	209951	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	57390867	69045	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	460	6	2	5	5.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCCC2)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934415	69045	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	460	6	2	5	5.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCCC2)cc1	10.1016/j.bmcl.2011.10.090
	117993763	170789	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4465341	170789	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	57392882	67725	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	440	9	2	5	4.3	CCCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916255	67725	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	440	9	2	5	4.3	CCCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	57394389	69047	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	464	9	2	6	4.1	COCCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934417	69047	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	464	9	2	6	4.1	COCCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.10.090
	57396150	69052	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	462	6	2	6	3.8	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOCC2)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934422	69052	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	462	6	2	6	3.8	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOCC2)cc1	10.1016/j.bmcl.2011.10.090
	53233899	1324	0	None	69	2	Human	6.5	pIC50	=	6.5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	5830	1324	0	None	69	2	Human	6.5	pIC50	=	6.5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	CHEMBL1770298	1324	0	None	69	2	Human	6.5	pIC50	=	6.5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	3939767	60956	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	440	8	1	5	5.2	CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccc(C#N)cc1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770475	60956	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	440	8	1	5	5.2	CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccc(C#N)cc1	10.1016/j.bmcl.2011.03.049
	4329947	2362	1	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	5829	2362	1	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	CHEMBL1770297	2362	1	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	57398257	67744	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	466	6	1	5	4.7	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916275	67744	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	466	6	1	5	4.7	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	57392729	69031	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	460	6	2	5	4.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2CC(F)(F)F)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934269	69031	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	460	6	2	5	4.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2CC(F)(F)F)cc1	10.1016/j.bmcl.2011.10.090
	57399614	69051	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	543	7	2	6	4.7	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCN(CC(F)(F)F)CC2)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934421	69051	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	543	7	2	6	4.7	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCN(CC(F)(F)F)CC2)cc1	10.1016/j.bmcl.2011.10.090
	54584753	60958	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	424	8	2	6	4.6	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncccc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770477	60958	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	424	8	2	6	4.6	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncccc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	155523344	169925	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	475	9	3	4	3.7	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1	10.1039/C9MD00336C
	CHEMBL4452346	169925	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	475	9	3	4	3.7	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1	10.1039/C9MD00336C
	155517073	169346	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4444413	169346	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	57396149	69048	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	478	6	2	6	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCSCC2)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934418	69048	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	478	6	2	6	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCSCC2)cc1	10.1016/j.bmcl.2011.10.090
	53233899	1324	0	None	69	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	5830	1324	0	None	69	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	CHEMBL1770298	1324	0	None	69	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	53233899	1324	0	None	69	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	5830	1324	0	None	69	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	CHEMBL1770298	1324	0	None	69	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	53233899	1324	0	None	69	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.08.085
	5830	1324	0	None	69	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.08.085
	CHEMBL1770298	1324	0	None	69	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O	10.1016/j.bmcl.2011.08.085
	57396214	69033	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	448	8	2	5	4.8	CCC(CC)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934271	69033	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	448	8	2	5	4.8	CCC(CC)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.10.090
	57392871	67707	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	438	6	2	5	4.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916084	67707	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	438	6	2	5	4.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	57394609	67730	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	427	8	2	6	3.3	CCC(CC)NC(=O)c1nnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916261	67730	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	427	8	2	6	3.3	CCC(CC)NC(=O)c1nnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	4881668	60896	7	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	379	6	2	4	4.8	CSCCC(NC(=O)c1oc2ccccc2c1C)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770309	60896	7	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	379	6	2	4	4.8	CSCCC(NC(=O)c1oc2ccccc2c1C)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	47012371	60898	5	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	329	6	2	4	3.7	CSCCC(NC(=O)c1occc1C)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770310	60898	5	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	329	6	2	4	3.7	CSCCC(NC(=O)c1occc1C)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	54584752	60950	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	341	6	3	4	3.5	CSCCC(NC(=O)c1ccccc1O)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770468	60950	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	341	6	3	4	3.5	CSCCC(NC(=O)c1ccccc1O)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL268823	206271	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CSCC[C@H](NC(=O)NCC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	102234371	112291	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	889	22	6	8	6.0	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311137	112291	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	889	22	6	8	6.0	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	71697968	173752	15	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4556626	173752	15	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL162488	204329	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	CHEMBL7122	209949	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	CHEMBL7034	209948	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CSCC[C@H](NC(=O)NC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	4329947	2362	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	5829	2362	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	CHEMBL1770297	2362	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	4329947	2362	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.08.085
	5829	2362	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.08.085
	CHEMBL1770297	2362	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.08.085
	57401682	67741	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	440	8	2	5	4.2	CCC(CC)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916272	67741	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	440	8	2	5	4.2	CCC(CC)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	57396468	67752	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916283	67752	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	4329947	2362	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	5829	2362	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	CHEMBL1770297	2362	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC	10.1016/j.bmcl.2011.03.049
	5322194	1751	10	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	376	3	1	5	2.3	CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C	10.1016/j.bmcl.2011.03.049
	5827	1751	10	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	376	3	1	5	2.3	CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C	10.1016/j.bmcl.2011.03.049
	CHEMBL1770295	1751	10	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	376	3	1	5	2.3	CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C	10.1016/j.bmcl.2011.03.049
	57398165	67728	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	412	8	2	5	3.6	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916259	67728	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	412	8	2	5	3.6	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1	10.1016/j.bmcl.2011.08.085
	57398166	67729	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	404	8	2	5	3.5	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)C1CCCC1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916260	67729	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	404	8	2	5	3.5	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)C1CCCC1	10.1016/j.bmcl.2011.08.085
	57398253	67736	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	440	9	2	5	4.0	CCC(CC)NC(=O)c1cnn(Cc2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916267	67736	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	440	9	2	5	4.0	CCC(CC)NC(=O)c1cnn(Cc2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.08.085
	57398255	67739	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	479	9	2	7	4.2	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916270	67739	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	479	9	2	7	4.2	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.1016/j.bmcl.2011.08.085
	57392964	67747	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	454	6	2	6	3.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916278	67747	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	454	6	2	6	3.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	54581782	60892	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	380	5	3	3	4.2	O=C(NC(C(=O)Nc1ccccc1)c1ccc(Cl)cc1)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	CHEMBL1770303	60892	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	380	5	3	3	4.2	O=C(NC(C(=O)Nc1ccccc1)c1ccc(Cl)cc1)c1ccccc1O	10.1016/j.bmcl.2011.03.049
	5157579	60949	15	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	325	6	2	3	3.8	CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770466	60949	15	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	325	6	2	3	3.8	CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2[nH]1	10.1016/j.bmcl.2011.03.049
	54581827	60959	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	425	8	2	7	4.0	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncncc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770478	60959	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	425	8	2	7	4.0	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncncc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	155523344	169925	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	475	9	3	4	3.7	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1	10.1039/C9MD00336C
	CHEMBL4452346	169925	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	475	9	3	4	3.7	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1	10.1039/C9MD00336C
	155517009	169339	0	None	3	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4444320	169339	0	None	3	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL7226	209952	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CSCC[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	CHEMBL7363	209954	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	ChEMBL		None	None	None		CCCCNC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm950908d
	54580796	60961	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	409	7	2	5	4.9	CCOc1ccc2oc(C(=O)N[C@H](CSC)c3nc4ccccc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770481	60961	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	409	7	2	5	4.9	CCOc1ccc2oc(C(=O)N[C@H](CSC)c3nc4ccccc4[nH]3)c(C)c2c1	10.1016/j.bmcl.2011.03.049
	57391103	67727	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	426	8	2	5	3.9	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1C	10.1016/j.bmcl.2011.08.085
	CHEMBL1916258	67727	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	426	8	2	5	3.9	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1C	10.1016/j.bmcl.2011.08.085
	57398256	67742	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	412	6	2	5	3.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916273	67742	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	412	6	2	5	3.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	57401427	69030	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	406	6	2	5	3.5	CCn1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934268	69030	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	406	6	2	5	3.5	CCn1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1	10.1016/j.bmcl.2011.10.090
	54587699	60960	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	391	7	2	4	5.0	CSCCC(NC(=O)c1sccc1Cl)c1ncc(-c2ccccc2)[nH]1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770479	60960	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	391	7	2	4	5.0	CSCCC(NC(=O)c1sccc1Cl)c1ncc(-c2ccccc2)[nH]1	10.1016/j.bmcl.2011.03.049
	71698276	172979	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	475	9	3	4	4.1	COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4538076	172979	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	475	9	3	4	4.1	COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	57401681	67740	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	519	8	1	7	5.1	CCN(C(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1)C1CCCCC1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916271	67740	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	519	8	1	7	5.1	CCN(C(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1)C1CCCCC1	10.1016/j.bmcl.2011.08.085
	57394707	67751	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916282	67751	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	57394707	67751	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1916282	67751	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.10.090
	57401369	69044	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	446	6	2	5	4.6	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCC2)cc1	10.1016/j.bmcl.2011.10.090
	CHEMBL1934414	69044	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	ChEMBL	446	6	2	5	4.6	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCC2)cc1	10.1016/j.bmcl.2011.10.090
	54581780	60889	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	402	5	3	3	4.7	Cc1cccc(C(NC(=O)c2ccccc2O)C(=O)Nc2c(C)cccc2C)c1C	10.1016/j.bmcl.2011.03.049
	CHEMBL1770300	60889	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	402	5	3	3	4.7	Cc1cccc(C(NC(=O)c2ccccc2O)C(=O)Nc2c(C)cccc2C)c1C	10.1016/j.bmcl.2011.03.049
	57399797	67710	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	474	7	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccc(C)cc3C)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916087	67710	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	474	7	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccc(C)cc3C)cnn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	57401683	67743	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	452	6	2	5	4.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916274	67743	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	ChEMBL	452	6	2	5	4.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	4654636	60888	8	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	408	5	3	3	4.8	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccc(Cl)cc1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770299	60888	8	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	408	5	3	3	4.8	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccc(Cl)cc1	10.1016/j.bmcl.2011.03.049
	54582743	60891	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	380	5	3	3	4.3	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)C1CCCCC1	10.1016/j.bmcl.2011.03.049
	CHEMBL1770302	60891	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	ChEMBL	380	5	3	3	4.3	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)C1CCCCC1	10.1016/j.bmcl.2011.03.049
	118707023	112285	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	781	20	6	8	4.3	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](COC(C)(C)C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311130	112285	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	781	20	6	8	4.3	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](COC(C)(C)C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311298	206861	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O	10.1016/j.bmc.2014.06.048
	54752118	67756	0	None	-	1	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level	ChEMBL	483	6	2	6	4.2	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.08.085
	CHEMBL1916288	67756	0	None	-	1	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level	ChEMBL	483	6	2	6	4.2	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.08.085
	CHEMBL3311144	206851	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311292	206855	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311294	206857	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C(=O)O)[C@@H](C)OC(C)(C)C	10.1016/j.bmc.2014.06.048
	118706970	112282	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	795	20	6	8	4.7	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311037	112282	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	795	20	6	8	4.7	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	118707032	112293	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	870	24	7	8	5.1	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311140	112293	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	870	24	7	8	5.1	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	118707031	112292	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	877	24	7	8	5.3	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)C1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311139	112292	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	877	24	7	8	5.3	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)C1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311291	206854	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311297	206860	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311299	206862	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O	10.1016/j.bmc.2014.06.048
	102234371	112291	0	None	-	1	Human	7.8	pKd	=	7.8	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	889	22	6	8	6.0	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311137	112291	0	None	-	1	Human	7.8	pKd	=	7.8	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	889	22	6	8	6.0	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311031	206841	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311293	206856	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](COC(C)(C)C)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL1934424	69054	0	None	-	1	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry	ChEMBL	490	7	2	6	4.6	CO[C@H]1CC[C@@H](n2nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c2NS(=O)(=O)c2ccc(C)cc2)CC1	10.1016/j.bmcl.2011.10.090
	CHEMBL3311134	206847	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	118707168	112308	0	None	-	1	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	893	22	6	8	6.6	CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311300	112308	0	None	-	1	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	893	22	6	8	6.6	CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311036	206846	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311142	206849	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311030	206840	17	None	-	1	Human	6.6	pKd	=	6.6	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311143	206850	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3309281	206838	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C(=O)O)C(C)C	10.1016/j.bmc.2014.06.048
	CHEMBL3311032	206842	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311033	206843	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311035	206845	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)O	10.1016/j.bmc.2014.06.048
	57394707	67751	0	None	-	1	Human	6.4	pKd	=	6.4	Functional	Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level	ChEMBL	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL1916282	67751	0	None	-	1	Human	6.4	pKd	=	6.4	Functional	Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level	ChEMBL	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1	10.1016/j.bmcl.2011.08.085
	CHEMBL3311034	206844	0	None	-	0	Human	6.4	pKd	=	6.4	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311289	206853	0	None	-	0	Human	6.3	pKd	=	6.3	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	118707169	112309	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	900	22	6	8	7.3	CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CCCCC1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311301	112309	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	900	22	6	8	7.3	CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CCCCC1)C(=O)O	10.1016/j.bmc.2014.06.048
	118707026	112288	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	857	21	6	8	5.9	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311133	112288	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	857	21	6	8	5.9	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	118707024	112286	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	791	20	6	7	5.5	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311131	112286	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	791	20	6	7	5.5	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311296	206859	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccc(OC(C)(C)C)cc1)C(=O)O	10.1016/j.bmc.2014.06.048
	118707029	112290	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	925	20	6	10	6.5	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311136	112290	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	925	20	6	10	6.5	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311138	206848	0	None	-	0	Human	6.1	pKd	=	6.1	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	118707025	112287	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	819	20	6	7	5.4	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311132	112287	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	819	20	6	7	5.4	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311295	206858	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CCCCC1)C(=O)O	10.1016/j.bmc.2014.06.048
	56949966	69055	0	None	-	1	Human	6.1	pKd	=	6.1	Functional	Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry	ChEMBL	488	7	2	6	4.4	Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.10.090
	CHEMBL1934426	69055	0	None	-	1	Human	6.1	pKd	=	6.1	Functional	Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry	ChEMBL	488	7	2	6	4.4	Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C	10.1016/j.bmcl.2011.10.090
	CHEMBL3311288	206852	0	None	-	0	Human	6.1	pKd	=	6.1	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)OC(C)(C)C	10.1016/j.bmc.2014.06.048
	118707028	112289	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	852	21	6	9	4.7	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1cn(C=O)c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	CHEMBL3311135	112289	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	ChEMBL	852	21	6	9	4.7	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1cn(C=O)c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.bmc.2014.06.048
	3092570	91	11	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	376	3	0	6	4.1	CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C	10.1016/j.bmcl.2011.03.049
	5828	91	11	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	376	3	0	6	4.1	CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C	10.1016/j.bmcl.2011.03.049
	CHEMBL1329101	91	11	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at FPR1Antagonist activity at FPR1	ChEMBL	376	3	0	6	4.1	CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C	10.1016/j.bmcl.2011.03.049
	2831216	40609	13	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	386	3	0	2	4.8	O=C1C(C23CC4CC(CC(C4)C2)C3)C(=O)N(c2ccccc2)N1c1ccccc1	nan
	CHEMBL1487404	40609	13	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	386	3	0	2	4.8	O=C1C(C23CC4CC(CC(C4)C2)C3)C(=O)N(c2ccccc2)N1c1ccccc1	nan
	CHEMBL1371060	27447	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	401	5	1	5	4.0	Cc1ccc(C2C(C(=O)c3ccc(Cl)cc3)=C(O)C(=O)N2CC2CCCO2)o1	nan
	658811	44180	8	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	355	3	1	5	4.1	CCC(=O)Nc1c(C#N)c2nc3ccccc3nc2n1-c1ccccc1C	nan
	CHEMBL1520286	44180	8	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	355	3	1	5	4.1	CCC(=O)Nc1c(C#N)c2nc3ccccc3nc2n1-c1ccccc1C	nan
	3152750	54167	12	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	349	5	1	5	3.7	O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1ccco1)c1ccco1	nan
	CHEMBL1611036	54167	12	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	349	5	1	5	3.7	O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1ccco1)c1ccco1	nan
	CHEMBL1599624	52846	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	314	1	1	6	4.0	Cc1ccsc1C1C2=C(O)CC(C)(C)CC2=Nc2ncnn21	nan
	CHEMBL1438893	35128	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	385	8	1	6	3.2	CCOc1cccc(C(=O)C2=C(O)C(=O)N(CCOC)C2c2ccc(C)o2)c1	nan
	655756	40212	11	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	360	5	1	5	3.5	O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1ccncc1)c1ccco1	nan
	CHEMBL1483985	40212	11	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	360	5	1	5	3.5	O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1ccncc1)c1ccco1	nan
	2950328	48626	12	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	449	10	1	7	4.2	CCCOc1ccc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCCn2ccnc2)cc1	nan
	CHEMBL1561325	48626	12	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	449	10	1	7	4.2	CCCOc1ccc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCCn2ccnc2)cc1	nan
	CHEMBL1392442	30046	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	299	1	1	4	3.6	Cc1nn2c(O)c3c(nc2c1-c1ccc(Cl)cc1)CCC3	nan
	2528	3491	78	None	-	1	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1	nan
	5342	3491	78	None	-	1	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1	nan
	5826	3491	78	None	-	1	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1	nan
	CHEMBL832	3491	78	None	-	1	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1	nan
	DB01138	3491	78	None	-	1	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1	nan
	2999882	26896	15	None	-	2	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	341	7	1	5	2.9	COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccccc1	nan
	CHEMBL1367025	26896	15	None	-	2	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	341	7	1	5	2.9	COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccccc1	nan
	661728	36501	14	None	-	0	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	419	7	1	5	3.7	COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccc(Br)cc1	nan
	CHEMBL1450917	36501	14	None	-	0	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	419	7	1	5	3.7	COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccc(Br)cc1	nan
	3237505	46438	5	None	-	1	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	345	2	2	5	3.2	O=C(NC1CCCC1)c1sc(=S)n2c1[nH]c(=O)c1ccccc12	nan
	CHEMBL1540596	46438	5	None	-	1	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	345	2	2	5	3.2	O=C(NC1CCCC1)c1sc(=S)n2c1[nH]c(=O)c1ccccc12	nan
	2919194	47408	12	None	-	1	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	404	7	1	6	3.9	CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2Cc2cccnc2)cc1	nan
	CHEMBL1548838	47408	12	None	-	1	Human	4.8	pKi	=	4.8	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	404	7	1	6	3.9	CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2Cc2cccnc2)cc1	nan
	CHEMBL1563387	48852	0	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	341	5	1	7	2.5	CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccc(OC)cc3)c2n1	nan
	3244340	51733	1	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	382	7	2	4	3.5	CCN(C(=O)Cc1c(C(=O)O)[nH]c2ccccc12)c1cc(OC)ccc1OC	nan
	CHEMBL1588313	51733	1	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	382	7	2	4	3.5	CCN(C(=O)Cc1c(C(=O)O)[nH]c2ccccc12)c1cc(OC)ccc1OC	nan
	CHEMBL1417363	32764	0	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	345	4	1	6	3.2	CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccc(Cl)cc3)c2n1	nan
	656027	33068	7	None	-	1	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	439	8	1	7	4.2	COc1ccc(CCN2C(=O)C(O)=C(C(=O)c3ccco3)C2c2cccs2)cc1OC	nan
	CHEMBL1420005	33068	7	None	-	1	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	439	8	1	7	4.2	COc1ccc(CCN2C(=O)C(O)=C(C(=O)c3ccco3)C2c2cccs2)cc1OC	nan
	1300651	43866	17	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	392	5	0	7	4.7	COc1ccccc1Oc1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O	nan
	CHEMBL1517379	43866	17	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	392	5	0	7	4.7	COc1ccccc1Oc1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O	nan
	3240009	43195	1	None	-	1	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	333	4	2	5	3.1	CCCCNC(=O)c1sc(=S)n2c1[nH]c(=O)c1ccccc12	nan
	CHEMBL1509433	43195	1	None	-	1	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	333	4	2	5	3.1	CCCCNC(=O)c1sc(=S)n2c1[nH]c(=O)c1ccccc12	nan
	5307697	35462	5	None	-	1	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	433	3	0	5	5.2	COc1ccc2ccccc2c1C1CC(=O)N2CN(C3CCCCC3)CSC2=C1C#N	nan
	CHEMBL1441874	35462	5	None	-	1	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	433	3	0	5	5.2	COc1ccc2ccccc2c1C1CC(=O)N2CN(C3CCCCC3)CSC2=C1C#N	nan
	654635	46577	11	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	433	7	2	6	4.1	COc1cc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCc2ccccc2)ccc1O	nan
	CHEMBL1541719	46577	11	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	433	7	2	6	4.1	COc1cc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCc2ccccc2)ccc1O	nan
	CHEMBL1602770	53169	0	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	353	6	2	5	2.3	COc1ccccc1C1C(C(=O)c2ccccc2)=C(O)C(=O)N1CCO	nan
	CHEMBL1459454	37519	0	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	265	1	1	4	2.9	Cc1nn2c(O)c3c(nc2c1-c1ccccc1)CCC3	nan
	1998413	23468	17	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	406	6	0	7	5.1	CCOc1ccccc1Oc1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O	nan
	CHEMBL1336347	23468	17	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	406	6	0	7	5.1	CCOc1ccccc1Oc1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O	nan
	CHEMBL1320528	21573	0	None	-	0	Human	4.7	pKi	=	4.7	Functional	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	ChEMBL	468	7	2	8	1.7	COC(=O)c1[nH]c(C)c(C(=O)C2=C(O)C(=O)N(CCN3CCOCC3)C2c2cccnc2)c1C	nan
	CHEMBL1466140	38337	0	None	-	0	Human	4.7	pKi	=	4.7	Functional

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Main reference

Ligand source activities (1 row/activity)