Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.8 | 10.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm00018a005 | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.8 | 10.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm00018a005 | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.8 | 10.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm00018a005 | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.8 | 10.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm00018a005 | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.8 | 10.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm00018a005 | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.8 | 10.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm00018a005 | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.8 | 10.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm00018a005 | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.8 | 10.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm00018a005 | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.8 | 10.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm00018a005 | |||||
CHEMBL413212 | 215515 | None | 0 | Human | Functional | pEC50 | = | 10.7 | 10.7 | 3 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm00018a005 | |||||
CHEMBL428615 | 215921 | None | 0 | Human | Functional | pEC50 | = | 10.7 | 10.7 | 1 | 5 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm00018a005 | |||||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.7 | 10.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030111j | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.7 | 10.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030111j | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.7 | 10.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030111j | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.7 | 10.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030111j | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.7 | 10.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030111j | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.7 | 10.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030111j | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.7 | 10.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030111j | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.7 | 10.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030111j | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 10.7 | 10.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030111j | |||||
155527254 | 171353 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | - | 1 | ChEMBL | 1038 | 17 | 14 | 11 | -0.6 | CCCCC(NC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL4460053 | 171353 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | - | 1 | ChEMBL | 1038 | 17 | 14 | 11 | -0.6 | CCCCC(NC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.8b00238 | |||
57646411 | 76949 | None | 0 | Human | Functional | pEC50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | 1739 | 49 | 24 | 20 | -1.7 | CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
CHEMBL2070245 | 76949 | None | 0 | Human | Functional | pEC50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | 1739 | 49 | 24 | 20 | -1.7 | CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
1323 | 2688 | None | 38 | Mouse | Functional | pEC50 | = | 10.4 | 10.4 | -1 | 7 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
92432 | 2688 | None | 38 | Mouse | Functional | pEC50 | = | 10.4 | 10.4 | -1 | 7 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
CHEMBL430239 | 2688 | None | 38 | Mouse | Functional | pEC50 | = | 10.4 | 10.4 | -1 | 7 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 10.4 | 10.4 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 10.4 | 10.4 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 10.4 | 10.4 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
118722941 | 116306 | None | 0 | Mouse | Functional | pEC50 | = | 10.3 | 10.3 | -1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3358549 | 116306 | None | 0 | Mouse | Functional | pEC50 | = | 10.3 | 10.3 | -1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
118722937 | 116302 | None | 0 | Mouse | Functional | pEC50 | = | 10.3 | 10.3 | -1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3358545 | 116302 | None | 0 | Mouse | Functional | pEC50 | = | 10.3 | 10.3 | -1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
118722933 | 116299 | None | 0 | Mouse | Functional | pEC50 | = | 10.2 | 10.2 | -1 | 3 | ChEMBL | 1038 | 33 | 13 | 11 | 1.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O | 10.1021/jm501027w | |||
CHEMBL3358541 | 116299 | None | 0 | Mouse | Functional | pEC50 | = | 10.2 | 10.2 | -1 | 3 | ChEMBL | 1038 | 33 | 13 | 11 | 1.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O | 10.1021/jm501027w | |||
1323 | 2688 | None | 38 | Mouse | Functional | pEC50 | = | 10.2 | 10.2 | -1 | 7 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
92432 | 2688 | None | 38 | Mouse | Functional | pEC50 | = | 10.2 | 10.2 | -1 | 7 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
CHEMBL430239 | 2688 | None | 38 | Mouse | Functional | pEC50 | = | 10.2 | 10.2 | -1 | 7 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
155551846 | 175238 | None | 0 | Human | Functional | pEC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 1589 | 48 | 22 | 20 | -3.2 | CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL4569789 | 175238 | None | 0 | Human | Functional | pEC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 1589 | 48 | 22 | 20 | -3.2 | CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL415661 | 215658 | None | 0 | Human | Functional | pEC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
CHEMBL2371851 | 212598 | None | 0 | Mouse | Functional | pEC50 | = | 10.2 | 10.2 | -1 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N1C(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]1CC(=O)O | 10.1021/jm0490843 | |||||
118722944 | 116309 | None | 0 | Mouse | Functional | pEC50 | = | 10.2 | 10.2 | 1 | 3 | ChEMBL | 1034 | 17 | 13 | 13 | -1.1 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3358552 | 116309 | None | 0 | Mouse | Functional | pEC50 | = | 10.2 | 10.2 | 1 | 3 | ChEMBL | 1034 | 17 | 13 | 13 | -1.1 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
1323 | 2688 | None | 38 | Mouse | Functional | pEC50 | = | 10.1 | 10.1 | -1 | 7 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
92432 | 2688 | None | 38 | Mouse | Functional | pEC50 | = | 10.1 | 10.1 | -1 | 7 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
CHEMBL430239 | 2688 | None | 38 | Mouse | Functional | pEC50 | = | 10.1 | 10.1 | -1 | 7 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
44310104 | 81619 | None | 0 | Mouse | Functional | pEC50 | = | 10.1 | 10.1 | -4 | 3 | ChEMBL | 1040 | 16 | 13 | 13 | -1.5 | CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CC(=O)ONCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm0303608 | |||
CHEMBL216295 | 81619 | None | 0 | Mouse | Functional | pEC50 | = | 10.1 | 10.1 | -4 | 3 | ChEMBL | 1040 | 16 | 13 | 13 | -1.5 | CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CC(=O)ONCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm0303608 | |||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm701093y | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm701093y | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm701093y | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm701093y | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm701093y | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm701093y | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm701093y | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm701093y | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm701093y | |||||
118722930 | 116297 | None | 0 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -1 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O | 10.1021/jm501027w | |||
CHEMBL3358539 | 116297 | None | 0 | Mouse | Functional | pEC50 | = | 10.0 | 10.0 | -1 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O | 10.1021/jm501027w | |||
CHEMBL412495 | 215458 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
16746823 | 18164 | None | 0 | Human | Functional | pEC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | 679 | 6 | 0 | 6 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CC(N(C)C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)c1ncnn1C | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL1269576 | 18164 | None | 0 | Human | Functional | pEC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | 679 | 6 | 0 | 6 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CC(N(C)C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)c1ncnn1C | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL2372570 | 212730 | None | 0 | Human | Functional | pEC50 | = | 10.0 | 10.0 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC2=NC=NC2)NC1=O | 10.1021/jm9017866 | |||||
CHEMBL407809 | 215145 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
90643803 | 111806 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -3 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287323 | 111806 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -3 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
10408 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
5329 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
9941379 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
9941379.0 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL2070241 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
DB11653 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | |||||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | |||||
118722926 | 116294 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | 1 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O | 10.1021/jm501027w | |||
CHEMBL3358535 | 116294 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | 1 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O | 10.1021/jm501027w | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0492756 | |||||
CHEMBL5090946 | 217775 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -4 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
172449425 | 195974 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | 123 | 4 | ChEMBL | 1148 | 14 | 16 | 18 | -2.8 | C[C@@H]1NC(=O)c2cc(-c3cn([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)nn3)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5414451 | 195974 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | 123 | 4 | ChEMBL | 1148 | 14 | 16 | 18 | -2.8 | C[C@@H]1NC(=O)c2cc(-c3cn([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)nn3)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
118722931 | 116298 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O | 10.1021/jm501027w | |||
CHEMBL3358540 | 116298 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O | 10.1021/jm501027w | |||
118722938 | 116303 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCc2cn(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3358546 | 116303 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCc2cn(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
118722942 | 116307 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | 1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cn2cc(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3358550 | 116307 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | 1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cn2cc(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
118722943 | 116308 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | 1 | 3 | ChEMBL | 1034 | 17 | 13 | 13 | -1.1 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3358551 | 116308 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | 1 | 3 | ChEMBL | 1034 | 17 | 13 | 13 | -1.1 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm201489a | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm201489a | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm201489a | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm201489a | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm201489a | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm201489a | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm201489a | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm201489a | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm201489a | |||||
127036484 | 136532 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -2 | 3 | ChEMBL | 1024 | 17 | 14 | 11 | -1.0 | CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1016/j.bmcl.2015.10.095 | |||
CHEMBL3735690 | 136532 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -2 | 3 | ChEMBL | 1024 | 17 | 14 | 11 | -1.0 | CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1016/j.bmcl.2015.10.095 | |||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2009.07.025 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2009.07.025 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2009.07.025 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2009.07.025 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2009.07.025 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2009.07.025 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2009.07.025 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2009.07.025 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2009.07.025 | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0490843 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0490843 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0490843 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0490843 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0490843 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0490843 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0490843 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0490843 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0490843 | |||||
57646437 | 76950 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 1855 | 51 | 23 | 23 | -2.2 | CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
70684621 | 76950 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 1855 | 51 | 23 | 23 | -2.2 | CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
91929804 | 76950 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 1855 | 51 | 23 | 23 | -2.2 | CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
CHEMBL2070246 | 76950 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 1855 | 51 | 23 | 23 | -2.2 | CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
127036484 | 136532 | None | 0 | Mouse | Functional | pEC50 | = | 9.8 | 9.8 | -2 | 3 | ChEMBL | 1024 | 17 | 14 | 11 | -1.0 | CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1016/j.bmcl.2015.10.095 | |||
CHEMBL3735690 | 136532 | None | 0 | Mouse | Functional | pEC50 | = | 9.8 | 9.8 | -2 | 3 | ChEMBL | 1024 | 17 | 14 | 11 | -1.0 | CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1016/j.bmcl.2015.10.095 | |||
CHEMBL266879 | 213165 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1021/jm0501432 | |||||
57646441 | 76948 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 1706 | 46 | 22 | 20 | -1.4 | CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
CHEMBL2070243 | 76948 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 1706 | 46 | 22 | 20 | -1.4 | CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
CHEMBL1688107 | 211293 | None | 0 | Mouse | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||||
CHEMBL5083551 | 217358 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | -10 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL2369484 | 212086 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NN[C@H]2Cc3ccc(O)cc3NC2=O)CC(=O)N[C@H](C(=O)NN[C@@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm0303608 | |||||
CHEMBL3646885 | 214483 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | 74 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCCNC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O | nan | |||||
118722927 | 116295 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CN=[N+]=[N-])C(N)=O | 10.1021/jm501027w | |||
CHEMBL3358536 | 116295 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CN=[N+]=[N-])C(N)=O | 10.1021/jm501027w | |||
CHEMBL3287329 | 213770 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c01587 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c01587 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c01587 | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm501027w | |||||
44415914 | 139357 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | 5 | 3 | ChEMBL | 762 | 16 | 6 | 7 | 1.8 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL379054 | 139357 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | 5 | 3 | ChEMBL | 762 | 16 | 6 | 7 | 1.8 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
10408 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/jm201489a | |||||
5329 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/jm201489a | |||||
9941379 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/jm201489a | |||||
9941379.0 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/jm201489a | |||||
CHEMBL2070241 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/jm201489a | |||||
DB11653 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/jm201489a | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm301253y | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm301253y | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm301253y | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm301253y | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm301253y | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm301253y | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm301253y | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm301253y | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm301253y | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm101425m | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm101425m | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm101425m | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm101425m | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm101425m | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm101425m | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm101425m | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm101425m | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm101425m | |||||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm049579s | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm049579s | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm049579s | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm049579s | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm049579s | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm049579s | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm049579s | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm049579s | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm049579s | |||||
CHEMBL405087 | 215001 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 5 | ChEMBL | None | None | None | C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O | 10.1021/jm030452x | |||||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
CHEMBL2372859 | 212759 | None | 1 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | 2 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm501027w | |||||
90643808 | 111810 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 4 | ChEMBL | 747 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287328 | 111810 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -14 | 4 | ChEMBL | 747 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010524p | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0303608 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0303608 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0303608 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0303608 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0303608 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0303608 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0303608 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0303608 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm0303608 | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm00018a005 | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm00018a005 | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm00018a005 | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm00018a005 | |||||
CHEMBL5080489 | 217177 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
118722936 | 116301 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3358544 | 116301 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
50899078 | 18161 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 623 | 4 | 0 | 5 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)c1ncnn1C | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL1269573 | 18161 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 623 | 4 | 0 | 5 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)c1ncnn1C | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL2373515 | 212838 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
90643802 | 111805 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287322 | 111805 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3646890 | 214488 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | 72 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCC(=O)NCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O | nan | |||||
10408 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
5329 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
9941379 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
9941379.0 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
CHEMBL2070241 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
DB11653 | 720 | None | 23 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
56659456 | 63722 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 655 | 4 | 1 | 4 | 6.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CC[C@@H](O)C1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801215 | 63722 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 655 | 4 | 1 | 4 | 6.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CC[C@@H](O)C1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL408257 | 215164 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | 2 | 2 | ChEMBL | None | None | None | CC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
90643804 | 111807 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -8 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287324 | 111807 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -8 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL264352 | 213076 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
CHEMBL1688107 | 211293 | None | 0 | Mouse | Functional | pEC50 | = | 9.6 | 9.6 | 1 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||||
172461542 | 196823 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | 17 | 3 | ChEMBL | 961 | 12 | 14 | 11 | -0.7 | C[C@H]1NC(=O)c2cc(C(=N)N)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5432868 | 196823 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | 17 | 3 | ChEMBL | 961 | 12 | 14 | 11 | -0.7 | C[C@H]1NC(=O)c2cc(C(=N)N)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5087839 | 217610 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | 2 | 3 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.6 | 9.6 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00053 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.6 | 9.6 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00053 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.6 | 9.6 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00053 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.6 | 9.6 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00053 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.6 | 9.6 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00053 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.6 | 9.6 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00053 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.6 | 9.6 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00053 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.6 | 9.6 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00053 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.6 | 9.6 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00053 | |||||
CHEMBL267900 | 213196 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | 5 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
CHEMBL491870 | 216565 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -9 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
118722932 | 115582 | None | 0 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 1038 | 33 | 13 | 11 | 1.2 | CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O | 10.1021/jm501027w | |||
CHEMBL3352878 | 115582 | None | 0 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -1 | 3 | ChEMBL | 1038 | 33 | 13 | 11 | 1.2 | CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O | 10.1021/jm501027w | |||
90643805 | 111808 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287325 | 111808 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030452x | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030452x | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030452x | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030452x | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030452x | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030452x | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030452x | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030452x | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm030452x | |||||
118735099 | 118863 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 4 | 4 | ChEMBL | 746 | 15 | 9 | 6 | 1.6 | CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O | 10.1021/ml500436s | |||
CHEMBL3421676 | 118863 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 4 | 4 | ChEMBL | 746 | 15 | 9 | 6 | 1.6 | CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O | 10.1021/ml500436s | |||
118735101 | 118865 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 9 | 4 | ChEMBL | 824 | 15 | 9 | 6 | 2.4 | CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(Br)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O | 10.1021/ml500436s | |||
CHEMBL3421678 | 118865 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 9 | 4 | ChEMBL | 824 | 15 | 9 | 6 | 2.4 | CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(Br)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O | 10.1021/ml500436s | |||
44415913 | 79982 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -4 | 3 | ChEMBL | 736 | 16 | 6 | 7 | 0.8 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL212614 | 79982 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -4 | 3 | ChEMBL | 736 | 16 | 6 | 7 | 0.8 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL385556 | 214814 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
CHEMBL3037885 | 213385 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -1 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.0c00561 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.0c00561 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.0c00561 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.0c00561 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.0c00561 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.0c00561 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.0c00561 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.0c00561 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.0c00561 | |||||
CHEMBL3646880 | 214479 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 29 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCNC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O | nan | |||||
CHEMBL5090285 | 217743 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -1 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL3358542 | 214028 | None | 0 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | 2 | 2 | ChEMBL | None | None | None | CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(C)=O)C(N)=O | 10.1021/jm501027w | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010061n | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010061n | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010061n | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010061n | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010061n | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010061n | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010061n | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010061n | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/jm010061n | |||||
CHEMBL429236 | 215977 | None | 0 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -15 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm010061n | |||||
44416057 | 81222 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 745 | 17 | 6 | 7 | 0.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL215833 | 81222 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 745 | 17 | 6 | 7 | 0.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
137637283 | 156071 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 2 | 3 | ChEMBL | 984 | 15 | 12 | 10 | -0.5 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4061566 | 156071 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 2 | 3 | ChEMBL | 984 | 15 | 12 | 10 | -0.5 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/acs.jmedchem.6b01707 | |||
122194229 | 124050 | None | 0 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -14 | 4 | ChEMBL | 1646 | 50 | 23 | 21 | -4.1 | CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2015.09.046 | |||
CHEMBL3629347 | 124050 | None | 0 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -14 | 4 | ChEMBL | 1646 | 50 | 23 | 21 | -4.1 | CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2015.09.046 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00170 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00170 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00170 | |||||
CHEMBL415165 | 215636 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0501432 | |||||
56666386 | 63723 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 655 | 4 | 1 | 4 | 6.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801216 | 63723 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 655 | 4 | 1 | 4 | 6.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2010.06.062 | |||
56676638 | 63714 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 655 | 4 | 0 | 4 | 6.7 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CCOCC1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801146 | 63714 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 655 | 4 | 0 | 4 | 6.7 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CCOCC1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL414965 | 215626 | None | 0 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -8 | 5 | ChEMBL | None | None | None | C[C@@H](O)[C@H](NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O | 10.1021/jm030452x | |||||
11993702 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | |||||
11993702.0 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | |||||
5416 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | |||||
9272 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL3301624 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | |||||
DB11700 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01707 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01707 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01707 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01707 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01707 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01707 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01707 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01707 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01707 | |||||
11993702 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | |||||
11993702.0 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | |||||
5416 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | |||||
9272 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | |||||
CHEMBL3301624 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | |||||
DB11700 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | |||||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
CHEMBL491870 | 216565 | None | 0 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | 3 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
90643806 | 111809 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287326 | 111809 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00856 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00856 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00856 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00856 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00856 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00856 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00856 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00856 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00856 | |||||
CHEMBL3646891 | 214489 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 30 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCC(=O)NCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O | nan | |||||
16172929 | 215461 | None | 14 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
CHEMBL412536 | 215461 | None | 14 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
6918780 | 63487 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 204 | 2 | ChEMBL | 637 | 10 | 2 | 6 | 3.6 | CCCN(c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL179836 | 63487 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 204 | 2 | ChEMBL | 637 | 10 | 2 | 6 | 3.6 | CCCN(c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL386081 | 214835 | None | 0 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -23 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm010061n | |||||
172441600 | 195257 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 5 | 4 | ChEMBL | 943 | 11 | 12 | 10 | -0.0 | C#Cc1ccc2c(c1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@H](C(N)=O)CS2 | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5399539 | 195257 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 5 | 4 | ChEMBL | 943 | 11 | 12 | 10 | -0.0 | C#Cc1ccc2c(c1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@H](C(N)=O)CS2 | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL444219 | 216391 | None | 0 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | 4 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
CHEMBL3287327 | 213769 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -5 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL267794 | 213192 | None | 0 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -13 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010061n | |||||
CHEMBL405335 | 215016 | None | 0 | Mouse | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm010061n | |||||
CHEMBL5090670 | 217767 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 3 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01894 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01894 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01894 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01894 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01894 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01894 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01894 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01894 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01894 | |||||
CHEMBL2070244 | 211643 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||||
122194229 | 124050 | None | 0 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 4 | ChEMBL | 1646 | 50 | 23 | 21 | -4.1 | CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2015.10.095 | |||
CHEMBL3629347 | 124050 | None | 0 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 4 | ChEMBL | 1646 | 50 | 23 | 21 | -4.1 | CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2015.10.095 | |||
44416106 | 141533 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 4 | 3 | ChEMBL | 617 | 12 | 4 | 5 | 1.5 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL384176 | 141533 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 4 | 3 | ChEMBL | 617 | 12 | 4 | 5 | 1.5 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
44448629 | 167561 | None | 0 | Rat | Functional | pEC50 | = | 9.3 | 9.3 | 3 | 4 | ChEMBL | 619 | 6 | 1 | 3 | 7.0 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL429854 | 167561 | None | 0 | Rat | Functional | pEC50 | = | 9.3 | 9.3 | 3 | 4 | ChEMBL | 619 | 6 | 1 | 3 | 7.0 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL3646882 | 214481 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 35 | 2 | ChEMBL | None | None | None | CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1CCCNC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O | nan | |||||
172441036 | 195202 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 5 | 3 | ChEMBL | 944 | 11 | 12 | 11 | -0.1 | C[C@H]1NC(=O)c2cc(C#N)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5398659 | 195202 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 5 | 3 | ChEMBL | 944 | 11 | 12 | 11 | -0.1 | C[C@H]1NC(=O)c2cc(C#N)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
CHEMBL413912 | 215560 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -7 | 3 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2004.07.046 | |||||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00552-3 | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00552-3 | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00552-3 | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00552-3 | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00552-3 | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00552-3 | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00552-3 | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00552-3 | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00552-3 | |||||
CHEMBL5080784 | 217194 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -2 | 4 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL264132 | 213065 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cncn2C)NC(=O)[C@@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
45487403 | 199891 | None | 0 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -53 | 4 | ChEMBL | 788 | 22 | 9 | 7 | 2.4 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC1=CN=CC1)NC(=O)CCCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL569693 | 199891 | None | 0 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | -53 | 4 | ChEMBL | 788 | 22 | 9 | 7 | 2.4 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC1=CN=CC1)NC(=O)CCCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL414718 | 215611 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm0501432 | |||||
127047475 | 139836 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 4 | ChEMBL | 1630 | 54 | 21 | 19 | -1.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
132991507 | 139836 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 4 | ChEMBL | 1630 | 54 | 21 | 19 | -1.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL3798421 | 139836 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 4 | ChEMBL | 1630 | 54 | 21 | 19 | -1.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL428801 | 215933 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -21 | 5 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm00018a005 | |||||
118722939 | 116304 | None | 0 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | 1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3358547 | 116304 | None | 0 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | 1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
10146211 | 64350 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 61 | 3 | ChEMBL | 649 | 10 | 2 | 6 | 3.6 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL181162 | 64350 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 61 | 3 | ChEMBL | 649 | 10 | 2 | 6 | 3.6 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
56669819 | 63712 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 625 | 4 | 0 | 3 | 7.0 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CCC1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801144 | 63712 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 625 | 4 | 0 | 3 | 7.0 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CCC1 | 10.1016/j.bmcl.2010.06.062 | |||
49862748 | 15155 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 657 | 5 | 0 | 6 | 5.8 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)N1CCOCC1 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209799 | 15155 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 657 | 5 | 0 | 6 | 5.8 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)N1CCOCC1 | 10.1016/j.bmcl.2010.06.068 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00114-8 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00114-8 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00114-8 | |||||
10146211 | 64350 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 61 | 3 | ChEMBL | 649 | 10 | 2 | 6 | 3.6 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL181162 | 64350 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 61 | 3 | ChEMBL | 649 | 10 | 2 | 6 | 3.6 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
11061068 | 31300 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 138 | 3 | ChEMBL | 603 | 8 | 2 | 7 | 4.0 | Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm025539h | |||
CHEMBL140154 | 31300 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 138 | 3 | ChEMBL | 603 | 8 | 2 | 7 | 4.0 | Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm025539h | |||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL3646884 | 214482 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 39 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCNC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O | nan | |||||
CHEMBL412523 | 215460 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
129627786 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
1330 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
16129617 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
16129674 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
16133751 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
16133802 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
16133802.0 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
16162116 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
3767 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
4516 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
60210072 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
6965 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
CHEMBL2103784 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
DB01284 | 280 | None | 26 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm500064t | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm500064t | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm500064t | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm500064t | |||||
127046235 | 139725 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 4 | ChEMBL | 1004 | 36 | 12 | 13 | -1.3 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL3797690 | 139725 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 4 | ChEMBL | 1004 | 36 | 12 | 13 | -1.3 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL428326 | 215899 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm0501432 | |||||
CHEMBL406842 | 215084 | None | 0 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 5 | ChEMBL | None | None | None | C[C@H](O)[C@@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O | 10.1021/jm030452x | |||||
56662904 | 63724 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 669 | 5 | 0 | 4 | 7.1 | CO[C@@H]1CCN(C(=O)C(C)(C)[C@H]2CC3(CCN(C(=O)[C@@H]4CN(C(C)(C)C)C[C@H]4c4ccc(F)cc4F)CC3)c3cc(Cl)c(C)cc32)C1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801217 | 63724 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 669 | 5 | 0 | 4 | 7.1 | CO[C@@H]1CCN(C(=O)C(C)(C)[C@H]2CC3(CCN(C(=O)[C@@H]4CN(C(C)(C)C)C[C@H]4c4ccc(F)cc4F)CC3)c3cc(Cl)c(C)cc32)C1 | 10.1016/j.bmcl.2010.06.062 | |||
90643803 | 111806 | None | 0 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | -1 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287323 | 111806 | None | 0 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | -1 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.3c00432 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.3c00432 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.3c00432 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.3c00432 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.3c00432 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.3c00432 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.3c00432 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.3c00432 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.3c00432 | |||||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960845e | |||||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960840h | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960840h | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960840h | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960840h | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960840h | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960840h | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960840h | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960840h | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm960840h | |||||
56669820 | 63715 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 4 | 0 | 4 | 6.8 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1C[C@@H]2C[C@H]1CO2 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801147 | 63715 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 4 | 0 | 4 | 6.8 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1C[C@@H]2C[C@H]1CO2 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL410763 | 215298 | None | 0 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -21 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010061n | |||||
CHEMBL412494 | 215457 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O | 10.1021/jm0501432 | |||||
CHEMBL3601426 | 214286 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 17 | 4 | ChEMBL | None | None | None | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O | 10.1021/acs.jmedchem.5b00102 | |||||
56676632 | 63699 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 625 | 5 | 1 | 3 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NC1CC1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801118 | 63699 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 625 | 5 | 1 | 3 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NC1CC1 | 10.1016/j.bmcl.2010.06.062 | |||
25129453 | 171869 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 15 | 3 | ChEMBL | 677 | 11 | 3 | 5 | 3.9 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1Cc2ccccc2CN1 | 10.1021/jm800525p | |||
CHEMBL446757 | 171869 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 15 | 3 | ChEMBL | 677 | 11 | 3 | 5 | 3.9 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1Cc2ccccc2CN1 | 10.1021/jm800525p | |||
49862750 | 15158 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 657 | 5 | 1 | 6 | 5.6 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209801 | 15158 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 657 | 5 | 1 | 6 | 5.6 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL3358537 | 214027 | None | 0 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -3 | 3 | ChEMBL | None | None | None | C#CC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O | 10.1021/jm501027w | |||||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL3646889 | 214487 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 31 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCNC(=O)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O | nan | |||||
118722940 | 116305 | None | 0 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3358548 | 116305 | None | 0 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3646892 | 214490 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 25 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCCNC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O | nan | |||||
56673302 | 63692 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 613 | 4 | 0 | 3 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N(C)C | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801095 | 63692 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 613 | 4 | 0 | 3 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N(C)C | 10.1016/j.bmcl.2010.06.062 | |||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00251 | |||||
CHEMBL5077095 | 216967 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -25 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
16746686 | 18163 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 651 | 5 | 0 | 6 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)c1ncnn1C | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL1269575 | 18163 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 651 | 5 | 0 | 6 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)c1ncnn1C | 10.1016/j.bmcl.2010.09.049 | |||
25133210 | 169560 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 44 | 3 | ChEMBL | 615 | 11 | 3 | 5 | 3.0 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1CCCN1 | 10.1021/jm800525p | |||
CHEMBL442829 | 169560 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 44 | 3 | ChEMBL | 615 | 11 | 3 | 5 | 3.0 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1CCCN1 | 10.1021/jm800525p | |||
25131478 | 169611 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 574 | 10 | 5 | 6 | 1.1 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C/C=N/NC(=N)N)C1=O | 10.1021/jm800525p | |||
CHEMBL443396 | 169611 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 574 | 10 | 5 | 6 | 1.1 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C/C=N/NC(=N)N)C1=O | 10.1021/jm800525p | |||
44569176 | 172648 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 48 | 3 | ChEMBL | 629 | 11 | 3 | 5 | 3.3 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H]1CCCCN1 | 10.1021/jm800525p | |||
CHEMBL448410 | 172648 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 48 | 3 | ChEMBL | 629 | 11 | 3 | 5 | 3.3 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H]1CCCCN1 | 10.1021/jm800525p | |||
44275650 | 94107 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -2 | 4 | ChEMBL | 953 | 15 | 12 | 10 | -0.8 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL24892 | 94107 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -2 | 4 | ChEMBL | 953 | 15 | 12 | 10 | -0.8 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00641 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00641 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00641 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00641 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00641 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00641 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00641 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00641 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00641 | |||||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00860 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00860 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00860 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00860 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00860 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00860 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00860 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00860 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b00860 | |||||
10886436 | 119221 | None | 0 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -1 | 4 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/acs.jmedchem.0c02041 | |||
CHEMBL342954 | 119221 | None | 0 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -1 | 4 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/acs.jmedchem.0c02041 | |||
44448660 | 95026 | None | 0 | Rat | Functional | pEC50 | = | 9.1 | 9.1 | 4 | 4 | ChEMBL | 575 | 6 | 1 | 3 | 6.9 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL254589 | 95026 | None | 0 | Rat | Functional | pEC50 | = | 9.1 | 9.1 | 4 | 4 | ChEMBL | 575 | 6 | 1 | 3 | 6.9 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
56659466 | 63694 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 599 | 4 | 1 | 3 | 6.6 | CNC(=O)C(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801097 | 63694 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 599 | 4 | 1 | 3 | 6.6 | CNC(=O)C(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL427666 | 215825 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | None | None | None | CSC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CSC)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(N)=O | 10.1021/jm0501432 | |||||
CHEMBL264190 | 213067 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -30 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL264536 | 213086 | None | 9 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | -20 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1021/jm010061n | |||||
127048118 | 173110 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 2236 | 54 | 25 | 25 | -5.6 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL4518266 | 173110 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 2236 | 54 | 25 | 25 | -5.6 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL5087859 | 217613 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -4 | 3 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
56683301 | 63718 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 657 | 4 | 0 | 3 | 7.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CC[C@H](F)C1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801150 | 63718 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 657 | 4 | 0 | 3 | 7.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CC[C@H](F)C1 | 10.1016/j.bmcl.2010.06.062 | |||
172453477 | 196059 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | 22 | 2 | ChEMBL | 1323 | 13 | 16 | 16 | 3.8 | C[C@@H]1NC(=O)c2cc(NC(=S)Nc3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5416095 | 196059 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | 22 | 2 | ChEMBL | 1323 | 13 | 16 | 16 | 3.8 | C[C@@H]1NC(=O)c2cc(NC(=S)Nc3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00830-2 | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00830-2 | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00830-2 | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00830-2 | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00830-2 | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00830-2 | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00830-2 | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00830-2 | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00830-2 | |||||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9 | 9.0 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2007.11.109 | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9 | 9.0 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2007.11.109 | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 9 | 9.0 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2007.11.109 | |||
56679968 | 63716 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 639 | 4 | 0 | 3 | 7.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CCCC1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801148 | 63716 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 639 | 4 | 0 | 3 | 7.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CCCC1 | 10.1016/j.bmcl.2010.06.062 | |||
172453477 | 196059 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 22 | 2 | ChEMBL | 1323 | 13 | 16 | 16 | 3.8 | C[C@@H]1NC(=O)c2cc(NC(=S)Nc3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5416095 | 196059 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 22 | 2 | ChEMBL | 1323 | 13 | 16 | 16 | 3.8 | C[C@@H]1NC(=O)c2cc(NC(=S)Nc3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
172457809 | 196344 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 3 | ChEMBL | 964 | 12 | 12 | 12 | -0.1 | C[C@H]1NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5421885 | 196344 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 3 | ChEMBL | 964 | 12 | 12 | 12 | -0.1 | C[C@H]1NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
70688853 | 76952 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 1495 | 39 | 18 | 16 | -0.1 | CCCCCCCCCCCCCCCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
CHEMBL2070248 | 76952 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 1495 | 39 | 18 | 16 | -0.1 | CCCCCCCCCCCCCCCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
11571540 | 135278 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 910 | 22 | 9 | 7 | 3.9 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2ccc(C(N)=O)cc2)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL372201 | 135278 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 910 | 22 | 9 | 7 | 3.9 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2ccc(C(N)=O)cc2)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
11593230 | 161324 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 958 | 22 | 10 | 7 | 4.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(NC(=O)Cc2ccccc2)CC[C@@H](c2ccccc2)CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(C(N)=O)cc1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL411817 | 161324 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 958 | 22 | 10 | 7 | 4.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(NC(=O)Cc2ccccc2)CC[C@@H](c2ccccc2)CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(C(N)=O)cc1 | 10.1016/j.bmcl.2005.08.083 | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00459-6 | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00459-6 | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00459-6 | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00459-6 | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00459-6 | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00459-6 | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00459-6 | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00459-6 | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(02)00459-6 | |||||
11851038 | 140422 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 497 | 6 | 0 | 5 | 5.2 | CN(C)[C@H]1C[C@@H](C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1021/jm050780s | |||
CHEMBL380691 | 140422 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 497 | 6 | 0 | 5 | 5.2 | CN(C)[C@H]1C[C@@H](C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1021/jm050780s | |||
CHEMBL5076315 | 216916 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL3287059 | 213757 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL502093 | 216637 | None | 0 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | 2 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Br)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
CHEMBL3799094 | 214728 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -8 | 4 | ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||||
56673305 | 63704 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 631 | 6 | 1 | 3 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NCCF | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801123 | 63704 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 631 | 6 | 1 | 3 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NCCF | 10.1016/j.bmcl.2010.06.062 | |||
56676639 | 63717 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 657 | 4 | 0 | 3 | 7.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CC[C@@H](F)C1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801149 | 63717 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 657 | 4 | 0 | 3 | 7.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CC[C@@H](F)C1 | 10.1016/j.bmcl.2010.06.062 | |||
49862736 | 15143 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | 117 | 2 | ChEMBL | 569 | 3 | 0 | 4 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209787 | 15143 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | 117 | 2 | ChEMBL | 569 | 3 | 0 | 4 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00198 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00198 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00198 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00198 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00198 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00198 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00198 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00198 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 8 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00198 | |||||
46919520 | 15144 | None | 0 | Rat | Functional | pEC50 | = | 9.0 | 9.0 | 2 | 6 | ChEMBL | 597 | 4 | 0 | 5 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209788 | 15144 | None | 0 | Rat | Functional | pEC50 | = | 9.0 | 9.0 | 2 | 6 | ChEMBL | 597 | 4 | 0 | 5 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
168281421 | 191066 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 3 | ChEMBL | 2430 | 43 | 34 | 31 | -3.4 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5185945 | 191066 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -10 | 3 | ChEMBL | 2430 | 43 | 34 | 31 | -3.4 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
11158573 | 71143 | None | 0 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -2 | 3 | ChEMBL | 783 | 25 | 9 | 7 | 2.1 | CCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL195439 | 71143 | None | 0 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -2 | 3 | ChEMBL | 783 | 25 | 9 | 7 | 2.1 | CCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
127047853 | 140080 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 4 | ChEMBL | 1948 | 72 | 23 | 25 | -2.1 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL3799955 | 140080 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 4 | ChEMBL | 1948 | 72 | 23 | 25 | -2.1 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
56676614 | 63725 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 669 | 5 | 0 | 4 | 7.1 | CO[C@H]1CCN(C(=O)C(C)(C)[C@H]2CC3(CCN(C(=O)[C@@H]4CN(C(C)(C)C)C[C@H]4c4ccc(F)cc4F)CC3)c3cc(Cl)c(C)cc32)C1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801218 | 63725 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 669 | 5 | 0 | 4 | 7.1 | CO[C@H]1CCN(C(=O)C(C)(C)[C@H]2CC3(CCN(C(=O)[C@@H]4CN(C(C)(C)C)C[C@H]4c4ccc(F)cc4F)CC3)c3cc(Cl)c(C)cc32)C1 | 10.1016/j.bmcl.2010.06.062 | |||
25129107 | 173881 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 36 | 3 | ChEMBL | 603 | 11 | 3 | 5 | 2.9 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C(C)(C)N | 10.1021/jm800525p | |||
CHEMBL453734 | 173881 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 36 | 3 | ChEMBL | 603 | 11 | 3 | 5 | 2.9 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C(C)(C)N | 10.1021/jm800525p | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL5077144 | 216973 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -13 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL5090946 | 217775 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL322610 | 213693 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -2 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL5091236 | 217789 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -48 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
44408287 | 75412 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 162 | 4 | ChEMBL | 620 | 8 | 2 | 5 | 5.1 | C[C@@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.11.095 | |||
CHEMBL203911 | 75412 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 162 | 4 | ChEMBL | 620 | 8 | 2 | 5 | 5.1 | C[C@@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.11.095 | |||
56659467 | 63707 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 629 | 6 | 2 | 4 | 5.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NCCO | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801126 | 63707 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 629 | 6 | 2 | 4 | 5.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NCCO | 10.1016/j.bmcl.2010.06.062 | |||
25133556 | 188957 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 7 | 3 | ChEMBL | 629 | 11 | 3 | 5 | 3.2 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCNCC1 | 10.1021/jm800525p | |||
CHEMBL506762 | 188957 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 7 | 3 | ChEMBL | 629 | 11 | 3 | 5 | 3.2 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCNCC1 | 10.1021/jm800525p | |||
168276507 | 190374 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -15 | 4 | ChEMBL | 2158 | 33 | 32 | 24 | -2.3 | CCCC[C@@H]1NC(=O)[C@@H]2CSCc3cccc(c3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5175487 | 190374 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -15 | 4 | ChEMBL | 2158 | 33 | 32 | 24 | -2.3 | CCCC[C@@H]1NC(=O)[C@@H]2CSCc3cccc(c3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
168289457 | 191489 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -7 | 4 | ChEMBL | 2158 | 33 | 32 | 24 | -2.3 | CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccccc3CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5192329 | 191489 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -7 | 4 | ChEMBL | 2158 | 33 | 32 | 24 | -2.3 | CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccccc3CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
137638778 | 156850 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 11 | 3 | ChEMBL | 1053 | 18 | 14 | 15 | -2.4 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4070639 | 156850 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 11 | 3 | ChEMBL | 1053 | 18 | 14 | 15 | -2.4 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
137633806 | 156572 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 10 | 3 | ChEMBL | 1031 | 14 | 14 | 13 | -2.0 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4067491 | 156572 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 10 | 3 | ChEMBL | 1031 | 14 | 14 | 13 | -2.0 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.7b00353 | |||
56662925 | 63697 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 613 | 5 | 1 | 3 | 7.0 | CCNC(=O)C(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801116 | 63697 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 613 | 5 | 1 | 3 | 7.0 | CCNC(=O)C(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL503229 | 216651 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O | 10.1021/jm801300c | |||||
134466953 | 156750 | None | 0 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 3 | ChEMBL | 1153 | 14 | 13 | 12 | -1.3 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4069451 | 156750 | None | 0 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 3 | ChEMBL | 1153 | 14 | 13 | 12 | -1.3 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
44310344 | 97382 | None | 0 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -13 | 3 | ChEMBL | 4414 | 53 | 53 | 68 | -9.9 | CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4 | 10.1021/jm0303608 | |||
77231883 | 97382 | None | 0 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -13 | 3 | ChEMBL | 4414 | 53 | 53 | 68 | -9.9 | CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4 | 10.1021/jm0303608 | |||
CHEMBL269274 | 97382 | None | 0 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -13 | 3 | ChEMBL | 4414 | 53 | 53 | 68 | -9.9 | CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4 | 10.1021/jm0303608 | |||
CHEMBL443071 | 216381 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON | 10.1021/jm049579s | |||||
CHEMBL410404 | 215279 | None | 0 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -11 | 5 | ChEMBL | None | None | None | C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O | 10.1021/jm030452x | |||||
10408 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
5329 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
9941379 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
9941379.0 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL2070241 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
DB11653 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.1c00095 | |||||
10408 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.2c00793 | |||||
5329 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.2c00793 | |||||
9941379 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.2c00793 | |||||
9941379.0 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.2c00793 | |||||
CHEMBL2070241 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.2c00793 | |||||
DB11653 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.2c00793 | |||||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm049278i | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm049278i | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm049278i | |||
CHEMBL3358533 | 214026 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -3 | 3 | ChEMBL | None | None | None | C#CC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN=[N+]=[N-])C(N)=O | 10.1021/jm501027w | |||||
49862745 | 15152 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 615 | 5 | 0 | 5 | 6.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)N(C)C | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209796 | 15152 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 615 | 5 | 0 | 5 | 6.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)N(C)C | 10.1016/j.bmcl.2010.06.068 | |||
90643803 | 111806 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -3 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287323 | 111806 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -3 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
172468014 | 196563 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 6 | 3 | ChEMBL | 934 | 11 | 13 | 11 | -0.4 | C[C@H]1NC(=O)c2cc(N)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5426684 | 196563 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 6 | 3 | ChEMBL | 934 | 11 | 13 | 11 | -0.4 | C[C@H]1NC(=O)c2cc(N)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5087814 | 217609 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -4 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
16132144 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm0490843 | |||||
16133793 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm0490843 | |||||
44273719 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm0490843 | |||||
CHEMBL214332 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm0490843 | |||||
44415920 | 80402 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 2 | 3 | ChEMBL | 644 | 12 | 4 | 6 | 1.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)N2CCNCC2)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL214410 | 80402 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 2 | 3 | ChEMBL | 644 | 12 | 4 | 6 | 1.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)N2CCNCC2)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
44416060 | 81349 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 66 | 3 | ChEMBL | 734 | 13 | 5 | 6 | 2.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2Cc3ccccc3CN2)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL215895 | 81349 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 66 | 3 | ChEMBL | 734 | 13 | 5 | 6 | 2.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2Cc3ccccc3CN2)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
44415912 | 139313 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 23 | 3 | ChEMBL | 575 | 11 | 4 | 5 | 1.3 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL378837 | 139313 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 23 | 3 | ChEMBL | 575 | 11 | 4 | 5 | 1.3 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
56683299 | 63710 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 627 | 5 | 0 | 3 | 7.3 | CCN(C)C(=O)C(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801142 | 63710 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 627 | 5 | 0 | 3 | 7.3 | CCN(C)C(=O)C(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
134463477 | 159345 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -5 | 3 | ChEMBL | 977 | 11 | 12 | 11 | -1.9 | C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4099127 | 159345 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -5 | 3 | ChEMBL | 977 | 11 | 12 | 11 | -1.9 | C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O | 10.1021/acs.jmedchem.6b01707 | |||
101670969 | 168999 | None | 21 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 3 | ChEMBL | 1623 | 49 | 22 | 22 | -4.3 | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C | 10.1021/acs.jmedchem.0c02041 | |||
16131138 | 168999 | None | 21 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 3 | ChEMBL | 1623 | 49 | 22 | 22 | -4.3 | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C | 10.1021/acs.jmedchem.0c02041 | |||
44349184 | 168999 | None | 21 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 3 | ChEMBL | 1623 | 49 | 22 | 22 | -4.3 | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C | 10.1021/acs.jmedchem.0c02041 | |||
53310908 | 168999 | None | 21 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 3 | ChEMBL | 1623 | 49 | 22 | 22 | -4.3 | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C | 10.1021/acs.jmedchem.0c02041 | |||
91898438 | 168999 | None | 21 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 3 | ChEMBL | 1623 | 49 | 22 | 22 | -4.3 | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C | 10.1021/acs.jmedchem.0c02041 | |||
CHEMBL438402 | 168999 | None | 21 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -2 | 3 | ChEMBL | 1623 | 49 | 22 | 22 | -4.3 | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C | 10.1021/acs.jmedchem.0c02041 | |||
118722935 | 116300 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | 1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
CHEMBL3358543 | 116300 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | 1 | 3 | ChEMBL | 1048 | 17 | 13 | 13 | -0.7 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm501027w | |||
42630327 | 155961 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -6 | 4 | ChEMBL | 1119 | 32 | 19 | 14 | -3.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(N)=O | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4060381 | 155961 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -6 | 4 | ChEMBL | 1119 | 32 | 19 | 14 | -3.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(N)=O | 10.1021/acs.jmedchem.8b00170 | |||
16007263 | 79827 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 23 | 3 | ChEMBL | 557 | 11 | 4 | 5 | 1.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccccc2)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL211975 | 79827 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 23 | 3 | ChEMBL | 557 | 11 | 4 | 5 | 1.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccccc2)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
56683300 | 63711 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 641 | 6 | 0 | 3 | 7.7 | CCN(CC)C(=O)C(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801143 | 63711 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 641 | 6 | 0 | 3 | 7.7 | CCN(CC)C(=O)C(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
25129109 | 188809 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 29 | 3 | ChEMBL | 603 | 12 | 3 | 5 | 2.8 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](C)NC | 10.1021/jm800525p | |||
CHEMBL504349 | 188809 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | 29 | 3 | ChEMBL | 603 | 12 | 3 | 5 | 2.8 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](C)NC | 10.1021/jm800525p | |||
16132144 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acsmedchemlett.5b00053 | |||||
16133793 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acsmedchemlett.5b00053 | |||||
44273719 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acsmedchemlett.5b00053 | |||||
CHEMBL214332 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acsmedchemlett.5b00053 | |||||
168293710 | 192275 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -19 | 4 | ChEMBL | 2158 | 33 | 32 | 24 | -2.3 | CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccc(cc3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5203986 | 192275 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -19 | 4 | ChEMBL | 2158 | 33 | 32 | 24 | -2.3 | CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccc(cc3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
168289404 | 191421 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -39 | 4 | ChEMBL | 2134 | 33 | 32 | 28 | -5.0 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5191309 | 191421 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -39 | 4 | ChEMBL | 2134 | 33 | 32 | 28 | -5.0 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
137635422 | 156000 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 30 | 3 | ChEMBL | 1111 | 22 | 15 | 16 | -2.3 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4060816 | 156000 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 30 | 3 | ChEMBL | 1111 | 22 | 15 | 16 | -2.3 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL264190 | 213067 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -30 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
24848934 | 78983 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 655 | 11 | 1 | 6 | 4.2 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2CN(C3CCCCC3)C2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL2113004 | 78983 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 655 | 11 | 1 | 6 | 4.2 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2CN(C3CCCCC3)C2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
16132144 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm0492756 | |||||
16133793 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm0492756 | |||||
44273719 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm0492756 | |||||
CHEMBL214332 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm0492756 | |||||
155531854 | 171751 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 2286 | 54 | 25 | 25 | -4.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL4466007 | 171751 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 2286 | 54 | 25 | 25 | -4.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
155563057 | 175402 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1680 | 54 | 21 | 19 | -0.0 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL4573190 | 175402 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1680 | 54 | 21 | 19 | -0.0 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
56662927 | 63709 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 657 | 6 | 2 | 4 | 6.7 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NC(C)(C)CO | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801141 | 63709 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 657 | 6 | 2 | 4 | 6.7 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NC(C)(C)CO | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL3287069 | 213766 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccc(O)c(I)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2005.02.068 | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2005.02.068 | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2005.02.068 | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2005.02.068 | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2004.10.020 | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2004.10.020 | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2004.10.020 | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2004.10.020 | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2005.05.109 | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2005.05.109 | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2005.05.109 | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2005.05.109 | |||||
44456222 | 97978 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 637 | 10 | 1 | 6 | 5.0 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1 | 10.1016/j.bmcl.2007.10.115 | |||
CHEMBL272538 | 97978 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 637 | 10 | 1 | 6 | 5.0 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1 | 10.1016/j.bmcl.2007.10.115 | |||
49862376 | 15046 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 624 | 8 | 0 | 6 | 5.2 | CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1ncccn1 | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209319 | 15046 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 624 | 8 | 0 | 6 | 5.2 | CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1ncccn1 | 10.1016/j.bmcl.2010.06.038 | |||
25133208 | 172097 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 4 | 3 | ChEMBL | 615 | 11 | 3 | 5 | 3.1 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CCC1 | 10.1021/jm800525p | |||
CHEMBL447117 | 172097 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 4 | 3 | ChEMBL | 615 | 11 | 3 | 5 | 3.1 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CCC1 | 10.1021/jm800525p | |||
145977650 | 163929 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -2 | 3 | ChEMBL | 865 | 11 | 12 | 9 | -0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL4206406 | 163929 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -2 | 3 | ChEMBL | 865 | 11 | 12 | 9 | -0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8 | 8.0 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01620 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8 | 8.0 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01620 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8 | 8.0 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01620 | |||||
11845272 | 80389 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 9 | 3 | ChEMBL | 632 | 12 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1 | 10.1021/jm060384p | |||
CHEMBL214347 | 80389 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 9 | 3 | ChEMBL | 632 | 12 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1 | 10.1021/jm060384p | |||
44275265 | 161384 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 14 | 2 | ChEMBL | 1066 | 13 | 11 | 9 | 1.6 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3ccc(Br)cc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL412174 | 161384 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 14 | 2 | ChEMBL | 1066 | 13 | 11 | 9 | 1.6 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3ccc(Br)cc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
90643802 | 111805 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287322 | 111805 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287327 | 213769 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -5 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
11851038 | 140422 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 497 | 6 | 0 | 5 | 5.2 | CN(C)[C@H]1C[C@@H](C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1021/jm050780s | |||
CHEMBL380691 | 140422 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 497 | 6 | 0 | 5 | 5.2 | CN(C)[C@H]1C[C@@H](C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1021/jm050780s | |||
44409257 | 140673 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 690 | 15 | 7 | 6 | 1.6 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL381357 | 140673 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 690 | 15 | 7 | 6 | 1.6 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2005.12.005 | |||
44409338 | 168847 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 739 | 19 | 7 | 6 | 3.4 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(O)cc1)NC(C)=O)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL437132 | 168847 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 739 | 19 | 7 | 6 | 3.4 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(O)cc1)NC(C)=O)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL412358 | 215446 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -10 | 2 | ChEMBL | None | None | None | CCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)00459-6 | |||||
44441684 | 94184 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 28 | 3 | ChEMBL | 571 | 7 | 3 | 5 | 3.1 | CC1CCC(C2(C(=O)NC(C)(C)C)CCN(C(=O)[C@H](Cc3ccc(F)cc3)NC(=O)[C@H]3CN(C)CCN3)CC2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL249321 | 94184 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 28 | 3 | ChEMBL | 571 | 7 | 3 | 5 | 3.1 | CC1CCC(C2(C(=O)NC(C)(C)C)CCN(C(=O)[C@H](Cc3ccc(F)cc3)NC(=O)[C@H]3CN(C)CCN3)CC2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL264190 | 213067 | None | 0 | Mouse | Functional | pEC50 | = | 8.0 | 8.0 | -2 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010061n | |||||
44448631 | 95123 | None | 0 | Rat | Functional | pEC50 | = | 8.0 | 8.0 | 1 | 4 | ChEMBL | 619 | 6 | 1 | 3 | 7.0 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL255286 | 95123 | None | 0 | Rat | Functional | pEC50 | = | 8.0 | 8.0 | 1 | 4 | ChEMBL | 619 | 6 | 1 | 3 | 7.0 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL5081077 | 217205 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -89 | 4 | ChEMBL | None | None | None | CN1C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]1CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
168295726 | 192514 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -117 | 4 | ChEMBL | 2547 | 50 | 34 | 33 | -2.8 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCOCCC(=O)O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5207936 | 192514 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -117 | 4 | ChEMBL | 2547 | 50 | 34 | 33 | -2.8 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCOCCC(=O)O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL589308 | 218289 | None | 0 | Mouse | Functional | pEC50 | = | 8.0 | 8.0 | -1 | 3 | ChEMBL | None | None | None | CC(=O)NCC(=O)N(CC(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)Cc1ccccc1)Cc1ccccc1 | 10.1016/j.bmc.2009.12.010 | |||||
44394659 | 66975 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 53 | 3 | ChEMBL | 754 | 19 | 9 | 7 | 1.5 | N#CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL186687 | 66975 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 53 | 3 | ChEMBL | 754 | 19 | 9 | 7 | 1.5 | N#CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
11239907 | 133195 | None | 0 | Mouse | Functional | pEC50 | = | 8.0 | 8.0 | -18 | 3 | ChEMBL | 854 | 30 | 9 | 7 | 4.1 | CCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL370261 | 133195 | None | 0 | Mouse | Functional | pEC50 | = | 8.0 | 8.0 | -18 | 3 | ChEMBL | 854 | 30 | 9 | 7 | 4.1 | CCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL264190 | 213067 | None | 0 | Mouse | Functional | pEC50 | = | 8.0 | 8.0 | -2 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||||
46228690 | 203949 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -63 | 2 | ChEMBL | 519 | 5 | 1 | 4 | 4.4 | O=C1[C@@H](Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)C=CN1CC(=O)N1CCCCc2ccccc21 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL605115 | 203949 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -63 | 2 | ChEMBL | 519 | 5 | 1 | 4 | 4.4 | O=C1[C@@H](Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)C=CN1CC(=O)N1CCCCc2ccccc21 | 10.1016/j.bmc.2010.01.049 | |||
137638218 | 156920 | None | 0 | Mouse | Functional | pEC50 | = | 7 | 7.0 | -2 | 3 | ChEMBL | 988 | 11 | 11 | 10 | -0.7 | C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4071283 | 156920 | None | 0 | Mouse | Functional | pEC50 | = | 7 | 7.0 | -2 | 3 | ChEMBL | 988 | 11 | 11 | 10 | -0.7 | C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
44373317 | 119722 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | 2 | 2 | ChEMBL | 787 | 22 | 9 | 9 | 0.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1csc2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
CHEMBL346930 | 119722 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | 2 | 2 | ChEMBL | 787 | 22 | 9 | 9 | 0.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1csc2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
16157270 | 215013 | None | 15 | Human | Functional | pEC50 | = | 7 | 7.0 | -162 | 6 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O | 10.1021/jm049579s | |||||
CHEMBL405282 | 215013 | None | 15 | Human | Functional | pEC50 | = | 7 | 7.0 | -162 | 6 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O | 10.1021/jm049579s | |||||
16157270 | 215013 | None | 15 | Human | Functional | pEC50 | = | 7 | 7.0 | -162 | 6 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O | 10.1021/jm000211e | |||||
CHEMBL405282 | 215013 | None | 15 | Human | Functional | pEC50 | = | 7 | 7.0 | -162 | 6 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O | 10.1021/jm000211e | |||||
71459896 | 78570 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | 6 | 2 | ChEMBL | 820 | 21 | 9 | 7 | 1.3 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2ccccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL2112064 | 78570 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | 6 | 2 | ChEMBL | 820 | 21 | 9 | 7 | 1.3 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2ccccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
44442998 | 93659 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 578 | 8 | 1 | 5 | 5.2 | O=C([C@H]1CN(C2CCOCC2)C[C@@H]1c1ccc(Cl)cc1)N1CCN(C2(CNCc3ccccc3)CCCCC2)CC1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL246631 | 93659 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 578 | 8 | 1 | 5 | 5.2 | O=C([C@H]1CN(C2CCOCC2)C[C@@H]1c1ccc(Cl)cc1)N1CCN(C2(CNCc3ccccc3)CCCCC2)CC1 | 10.1016/j.bmcl.2007.10.032 | |||
44443016 | 94141 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 566 | 9 | 1 | 5 | 5.4 | COc1ccccc1CNCC1(N2CCN(C(=O)[C@H]3CN(C(C)C)C[C@@H]3c3ccc(Cl)cc3)CC2)CCCCC1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL249064 | 94141 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 566 | 9 | 1 | 5 | 5.4 | COc1ccccc1CNCC1(N2CCN(C(=O)[C@H]3CN(C(C)C)C[C@@H]3c3ccc(Cl)cc3)CC2)CCCCC1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL3600921 | 214284 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -7 | 4 | ChEMBL | None | None | None | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O | 10.1021/acs.jmedchem.5b00102 | |||||
11706338 | 204164 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -33 | 2 | ChEMBL | 523 | 7 | 2 | 5 | 4.2 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(O)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL1237150 | 204164 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -33 | 2 | ChEMBL | 523 | 7 | 2 | 5 | 4.2 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(O)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL1237166 | 204164 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -33 | 2 | ChEMBL | 523 | 7 | 2 | 5 | 4.2 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(O)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL606399 | 204164 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -33 | 2 | ChEMBL | 523 | 7 | 2 | 5 | 4.2 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(O)cc1 | 10.1016/j.bmc.2010.01.049 | |||
145966364 | 164215 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -131 | 3 | ChEMBL | 865 | 11 | 12 | 9 | -0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL4209913 | 164215 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -131 | 3 | ChEMBL | 865 | 11 | 12 | 9 | -0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL320157 | 213685 | None | 0 | Mouse | Functional | pEC50 | = | 6 | 6.0 | -1 | 3 | ChEMBL | None | None | None | CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.9b00198 | |||||
11851038 | 140422 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 497 | 6 | 0 | 5 | 5.2 | CN(C)[C@H]1C[C@@H](C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1021/jm050780s | |||
CHEMBL380691 | 140422 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 497 | 6 | 0 | 5 | 5.2 | CN(C)[C@H]1C[C@@H](C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1021/jm050780s | |||
44349170 | 116887 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 650 | 9 | 4 | 5 | 4.8 | O=C(NCc1ccccc1)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL337941 | 116887 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 650 | 9 | 4 | 5 | 4.8 | O=C(NCc1ccccc1)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/s0960-894x(03)00796-0 | |||
44348844 | 118267 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 665 | 11 | 2 | 6 | 4.0 | CCC(C)N(Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL340908 | 118267 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 665 | 11 | 2 | 6 | 4.0 | CCC(C)N(Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL381739 | 214752 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | -8 | 3 | ChEMBL | None | None | None | CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O | 10.1021/jm0510326 | |||||
44305763 | 205544 | None | 0 | Mouse | Functional | pEC50 | = | 4 | 4.0 | -5 | 3 | ChEMBL | 490 | 11 | 5 | 4 | 3.1 | NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCC(Cc2ccccc2)CC1 | 10.1016/s0960-894x(03)00318-4 | |||
CHEMBL63850 | 205544 | None | 0 | Mouse | Functional | pEC50 | = | 4 | 4.0 | -5 | 3 | ChEMBL | 490 | 11 | 5 | 4 | 3.1 | NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCC(Cc2ccccc2)CC1 | 10.1016/s0960-894x(03)00318-4 | |||
164612768 | 184825 | None | 0 | Mouse | Functional | pEC50 | = | 4 | 4.0 | -165 | 3 | ChEMBL | 591 | 10 | 3 | 3 | 6.3 | CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N | 10.1021/acs.jmedchem.0c02041 | |||
CHEMBL4850501 | 184825 | None | 0 | Mouse | Functional | pEC50 | = | 4 | 4.0 | -165 | 3 | ChEMBL | 591 | 10 | 3 | 3 | 6.3 | CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N | 10.1021/acs.jmedchem.0c02041 | |||
164613353 | 184881 | None | 0 | Mouse | Functional | pEC50 | = | 4 | 4.0 | - | 1 | ChEMBL | 539 | 13 | 4 | 4 | 4.0 | CC(C)CCCN1C(=N)N([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C[C@H]1[C@@H](C)O | 10.1021/acs.jmedchem.0c02041 | |||
CHEMBL4851292 | 184881 | None | 0 | Mouse | Functional | pEC50 | = | 4 | 4.0 | - | 1 | ChEMBL | 539 | 13 | 4 | 4 | 4.0 | CC(C)CCCN1C(=N)N([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C[C@H]1[C@@H](C)O | 10.1021/acs.jmedchem.0c02041 | |||
164613550 | 185235 | None | 0 | Mouse | Functional | pEC50 | = | 4 | 4.0 | -177 | 3 | ChEMBL | 606 | 11 | 3 | 3 | 6.7 | CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N | 10.1021/acs.jmedchem.0c02041 | |||
CHEMBL4856539 | 185235 | None | 0 | Mouse | Functional | pEC50 | = | 4 | 4.0 | -177 | 3 | ChEMBL | 606 | 11 | 3 | 3 | 6.7 | CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N | 10.1021/acs.jmedchem.0c02041 | |||
45487298 | 199798 | None | 0 | Mouse | Functional | pEC50 | = | 5 | 5.0 | -12 | 3 | ChEMBL | 657 | 17 | 8 | 8 | 0.4 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/C=C/c1ccc2c(c1)OCO2)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL568965 | 199798 | None | 0 | Mouse | Functional | pEC50 | = | 5 | 5.0 | -12 | 3 | ChEMBL | 657 | 17 | 8 | 8 | 0.4 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/C=C/c1ccc2c(c1)OCO2)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
49862663 | 15128 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 613 | 3 | 0 | 5 | 7.0 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(=O)OC(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209705 | 15128 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 613 | 3 | 0 | 5 | 7.0 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(=O)OC(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
44413576 | 78185 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -3 | 2 | ChEMBL | 725 | 10 | 10 | 7 | 0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)CCCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
CHEMBL210399 | 78185 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -3 | 2 | ChEMBL | 725 | 10 | 10 | 7 | 0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)CCCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
CHEMBL5091245 | 217790 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -5 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
46228814 | 201832 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -2 | 2 | ChEMBL | 617 | 10 | 2 | 6 | 4.9 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)C(Cc3cc[nH]n3)(Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL590955 | 201832 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -2 | 2 | ChEMBL | 617 | 10 | 2 | 6 | 4.9 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)C(Cc3cc[nH]n3)(Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
137646617 | 157636 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -2 | 4 | ChEMBL | 1728 | 21 | 21 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4080223 | 157636 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -2 | 4 | ChEMBL | 1728 | 21 | 21 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
44433423 | 88758 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 496 | 6 | 1 | 4 | 5.1 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1 | 10.1016/j.bmcl.2007.09.079 | |||
CHEMBL236110 | 88758 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 496 | 6 | 1 | 4 | 5.1 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1 | 10.1016/j.bmcl.2007.09.079 | |||
44433423 | 88758 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 496 | 6 | 1 | 4 | 5.1 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL236110 | 88758 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 496 | 6 | 1 | 4 | 5.1 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1 | 10.1016/j.bmcl.2007.06.088 | |||
46885368 | 7958 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 10 | 3 | ChEMBL | 470 | 6 | 1 | 3 | 4.8 | CCCCN1C[C@H](c2ccc(F)cc2F)[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)C1 | 10.1021/jm9017866 | |||
CHEMBL1090484 | 7958 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 10 | 3 | ChEMBL | 470 | 6 | 1 | 3 | 4.8 | CCCCN1C[C@H](c2ccc(F)cc2F)[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)C1 | 10.1021/jm9017866 | |||
44275312 | 141494 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 70 | 2 | ChEMBL | 1023 | 13 | 11 | 9 | 1.9 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3c(Cl)cccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL384036 | 141494 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 70 | 2 | ChEMBL | 1023 | 13 | 11 | 9 | 1.9 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3c(Cl)cccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
44394627 | 124148 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 7 | 3 | ChEMBL | 757 | 20 | 8 | 6 | 2.1 | CCCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL363272 | 124148 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 7 | 3 | ChEMBL | 757 | 20 | 8 | 6 | 2.1 | CCCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
46228726 | 202947 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -3 | 2 | ChEMBL | 507 | 7 | 1 | 4 | 4.5 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)[C@H](Cc2n[nH]c3ccccc23)C1=O)c1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL598643 | 202947 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -3 | 2 | ChEMBL | 507 | 7 | 1 | 4 | 4.5 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)[C@H](Cc2n[nH]c3ccccc23)C1=O)c1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
137646617 | 157636 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -2 | 4 | ChEMBL | 1728 | 21 | 21 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4080223 | 157636 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -2 | 4 | ChEMBL | 1728 | 21 | 21 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
46202892 | 7758 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 538 | 3 | 1 | 3 | 5.8 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm9017866 | |||
CHEMBL1089107 | 7758 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 538 | 3 | 1 | 3 | 5.8 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm9017866 | |||
CHEMBL1204062 | 7758 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 538 | 3 | 1 | 3 | 5.8 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm9017866 | |||
CHEMBL438596 | 216242 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm050780s | |||||
44413969 | 80261 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -24 | 3 | ChEMBL | 584 | 12 | 5 | 5 | 3.5 | N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1 | 10.1021/jm060384p | |||
CHEMBL213752 | 80261 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -24 | 3 | ChEMBL | 584 | 12 | 5 | 5 | 3.5 | N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1 | 10.1021/jm060384p | |||
44310258 | 159512 | None | 0 | Mouse | Functional | pEC50 | = | 5.0 | 5.0 | -4 | 3 | ChEMBL | 1421 | 24 | 20 | 20 | -4.6 | C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O | 10.1021/jm0303608 | |||
91932908 | 159512 | None | 0 | Mouse | Functional | pEC50 | = | 5.0 | 5.0 | -4 | 3 | ChEMBL | 1421 | 24 | 20 | 20 | -4.6 | C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O | 10.1021/jm0303608 | |||
CHEMBL410091 | 159512 | None | 0 | Mouse | Functional | pEC50 | = | 5.0 | 5.0 | -4 | 3 | ChEMBL | 1421 | 24 | 20 | 20 | -4.6 | C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O | 10.1021/jm0303608 | |||
44413968 | 80260 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -57 | 3 | ChEMBL | 632 | 12 | 5 | 5 | 4.0 | N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1 | 10.1021/jm060384p | |||
CHEMBL213751 | 80260 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -57 | 3 | ChEMBL | 632 | 12 | 5 | 5 | 4.0 | N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1 | 10.1021/jm060384p | |||
CHEMBL444493 | 216394 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 37 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2C[C@H](NC(=N)N)CN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm801300c | |||||
CHEMBL438596 | 216242 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm050780s | |||||
44405911 | 140594 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 994 | 20 | 10 | 7 | 4.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)Cc2ccccc2)CCc2c(Br)cccc2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1C(N)=O | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL381007 | 140594 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 994 | 20 | 10 | 7 | 4.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)Cc2ccccc2)CCc2c(Br)cccc2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1C(N)=O | 10.1016/j.bmcl.2005.08.083 | |||
1337 | 3424 | None | 5 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
6918851 | 3424 | None | 5 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
CHEMBL364346 | 3424 | None | 5 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
9808720 | 64243 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 3 | 2 | ChEMBL | 595 | 8 | 3 | 6 | 2.8 | CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL180892 | 64243 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 3 | 2 | ChEMBL | 595 | 8 | 3 | 6 | 2.8 | CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
6918813 | 131439 | None | 2 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 77 | 4 | ChEMBL | 557 | 7 | 3 | 5 | 2.9 | CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL368876 | 131439 | None | 2 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 77 | 4 | ChEMBL | 557 | 7 | 3 | 5 | 2.9 | CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL91957 | 218395 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 3 | 3 | ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NS(=O)(=O)c1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||||
168278271 | 191224 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -23 | 4 | ChEMBL | 2167 | 35 | 34 | 26 | -5.3 | CCCC[C@@H]1NC(=O)[C@@H]2CS/C(C(=O)O)=C(/C(N)=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5187932 | 191224 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -23 | 4 | ChEMBL | 2167 | 35 | 34 | 26 | -5.3 | CCCC[C@@H]1NC(=O)[C@@H]2CS/C(C(=O)O)=C(/C(N)=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
137656521 | 159838 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 12 | 3 | ChEMBL | 1139 | 22 | 17 | 16 | -3.1 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4104927 | 159838 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 12 | 3 | ChEMBL | 1139 | 22 | 17 | 16 | -3.1 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
44322895 | 163465 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -5 | 3 | ChEMBL | 811 | 21 | 10 | 8 | 1.3 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)COc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL419307 | 163465 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -5 | 3 | ChEMBL | 811 | 21 | 10 | 8 | 1.3 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)COc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
44442954 | 94352 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 526 | 8 | 2 | 5 | 4.1 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4c[nH]cn4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL250495 | 94352 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 526 | 8 | 2 | 5 | 4.1 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4c[nH]cn4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
24848995 | 118011 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 583 | 8 | 2 | 7 | 3.1 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cncn2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm049278i | |||
CHEMBL340355 | 118011 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 583 | 8 | 2 | 7 | 3.1 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cncn2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm049278i | |||
145973975 | 164752 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -16 | 4 | ChEMBL | 901 | 11 | 12 | 9 | 0.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL4216654 | 164752 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -16 | 4 | ChEMBL | 901 | 11 | 12 | 9 | 0.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
90643846 | 111831 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 692 | 15 | 8 | 7 | 0.0 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287353 | 111831 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 692 | 15 | 8 | 7 | 0.0 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
90643850 | 111834 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 711 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287357 | 111834 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 711 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
44405802 | 72885 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 921 | 22 | 8 | 7 | 4.6 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc2ccc3ccccc3c2)C(=O)NCc2cccc(C(N)=O)c2)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL200270 | 72885 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 921 | 22 | 8 | 7 | 4.6 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc2ccc3ccccc3c2)C(=O)NCc2cccc(C(N)=O)c2)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
44349055 | 16473 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 613 | 9 | 2 | 8 | 3.1 | COc1ccc(Cn2cncn2)c(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)c1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL123426 | 16473 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 613 | 9 | 2 | 8 | 3.1 | COc1ccc(Cn2cncn2)c(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)c1 | 10.1016/s0960-894x(03)00796-0 | |||
11295737 | 120277 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 544 | 7 | 2 | 4 | 4.6 | CC(C)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
CHEMBL352063 | 120277 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 544 | 7 | 2 | 4 | 4.6 | CC(C)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
24848995 | 118011 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 583 | 8 | 2 | 7 | 3.1 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cncn2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL340355 | 118011 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 583 | 8 | 2 | 7 | 3.1 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cncn2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
70695694 | 78445 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 770 | 22 | 10 | 8 | -0.7 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
CHEMBL2111251 | 78445 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 770 | 22 | 10 | 8 | -0.7 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
44397652 | 123701 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 14 | 2 | ChEMBL | 620 | 10 | 2 | 7 | 6.0 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL361883 | 123701 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 14 | 2 | ChEMBL | 620 | 10 | 2 | 7 | 6.0 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
44397461 | 126295 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 16 | 3 | ChEMBL | 606 | 10 | 2 | 7 | 5.6 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL365005 | 126295 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 16 | 3 | ChEMBL | 606 | 10 | 2 | 7 | 5.6 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
44448661 | 95052 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 575 | 6 | 1 | 3 | 6.9 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Cl)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL254792 | 95052 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 575 | 6 | 1 | 3 | 6.9 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Cl)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
44442931 | 150478 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 536 | 8 | 1 | 4 | 5.4 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ccccc4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL395355 | 150478 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 536 | 8 | 1 | 4 | 5.4 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ccccc4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
44443027 | 155110 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 579 | 9 | 1 | 5 | 5.5 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ccc(N(C)C)cc4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL401488 | 155110 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 579 | 9 | 1 | 5 | 5.5 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ccc(N(C)C)cc4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
44433384 | 154800 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 564 | 7 | 1 | 4 | 6.2 | CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.079 | |||
CHEMBL399801 | 154800 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 564 | 7 | 1 | 4 | 6.2 | CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.079 | |||
44433384 | 154800 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 564 | 7 | 1 | 4 | 6.2 | CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL399801 | 154800 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 564 | 7 | 1 | 4 | 6.2 | CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL3287356 | 213774 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||||
137645898 | 158110 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | -27 | 2 | ChEMBL | 797 | 10 | 9 | 8 | -1.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4085584 | 158110 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | -27 | 2 | ChEMBL | 797 | 10 | 9 | 8 | -1.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
155558348 | 175140 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | -61 | 3 | ChEMBL | 677 | 19 | 9 | 7 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4567480 | 175140 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | -61 | 3 | ChEMBL | 677 | 19 | 9 | 7 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
155566298 | 175897 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | -85 | 3 | ChEMBL | 683 | 16 | 8 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4584189 | 175897 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | -85 | 3 | ChEMBL | 683 | 16 | 8 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL343094 | 214156 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | -6 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2003.08.078 | |||||
44349006 | 114516 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 622 | 8 | 3 | 6 | 4.1 | O=C(Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)c1cccnc1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL333368 | 114516 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 622 | 8 | 3 | 6 | 4.1 | O=C(Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)c1cccnc1 | 10.1016/s0960-894x(03)00796-0 | |||
44397534 | 67289 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 621 | 10 | 2 | 8 | 5.1 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@@H]3CNCCN3c3ccc(F)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL188142 | 67289 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 621 | 10 | 2 | 8 | 5.1 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@@H]3CNCCN3c3ccc(F)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
44397698 | 126269 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 616 | 10 | 2 | 7 | 6.2 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(C)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL364992 | 126269 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 616 | 10 | 2 | 7 | 6.2 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(C)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
1337 | 3424 | None | 5 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
6918851 | 3424 | None | 5 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
CHEMBL364346 | 3424 | None | 5 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
1337 | 3424 | None | 5 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
6918851 | 3424 | None | 5 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
CHEMBL364346 | 3424 | None | 5 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
1337 | 3424 | None | 5 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
6918851 | 3424 | None | 5 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
CHEMBL364346 | 3424 | None | 5 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 3 | 5 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.05.109 | |||
46885561 | 7814 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 492 | 4 | 1 | 5 | 4.0 | C[C@H]1CN(C(=O)[C@H]2CN(c3cnccn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL1089487 | 7814 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 492 | 4 | 1 | 5 | 4.0 | C[C@H]1CN(C(=O)[C@H]2CN(c3cnccn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
44441646 | 154177 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 10 | 3 | ChEMBL | 611 | 9 | 2 | 7 | 3.7 | Cn1nnnc1CC1(Cc2ccccc2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL398487 | 154177 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 10 | 3 | ChEMBL | 611 | 9 | 2 | 7 | 3.7 | Cn1nnnc1CC1(Cc2ccccc2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
122184912 | 122624 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -2 | 4 | ChEMBL | 1130 | 17 | 10 | 11 | 1.5 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O | 10.1021/acs.jmedchem.5b00102 | |||
CHEMBL3601430 | 122624 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -2 | 4 | ChEMBL | 1130 | 17 | 10 | 11 | 1.5 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O | 10.1021/acs.jmedchem.5b00102 | |||
46203214 | 7863 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 472 | 3 | 1 | 5 | 3.6 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cncnc1 | 10.1021/jm9017866 | |||
CHEMBL1089831 | 7863 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 472 | 3 | 1 | 5 | 3.6 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cncnc1 | 10.1021/jm9017866 | |||
CHEMBL1204064 | 7863 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 472 | 3 | 1 | 5 | 3.6 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cncnc1 | 10.1021/jm9017866 | |||
CHEMBL430843 | 216082 | None | 0 | Mouse | Functional | pEC50 | = | 5.0 | 5.0 | -3 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](CCc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010524p | |||||
16038121 | 106760 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -8 | 2 | ChEMBL | 697 | 10 | 10 | 7 | -0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
CHEMBL3143817 | 106760 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -8 | 2 | ChEMBL | 697 | 10 | 10 | 7 | -0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
46885674 | 7961 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 442 | 3 | 1 | 3 | 4.3 | CC(C)(C)N1C[C@@H](C(=O)N2CCC(O)(c3ccccc3)CC2)[C@H](c2ccc(F)cc2F)C1 | 10.1021/jm9017866 | |||
CHEMBL1090487 | 7961 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 442 | 3 | 1 | 3 | 4.3 | CC(C)(C)N1C[C@@H](C(=O)N2CCC(O)(c3ccccc3)CC2)[C@H](c2ccc(F)cc2F)C1 | 10.1021/jm9017866 | |||
137656033 | 158735 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 1034 | 20 | 15 | 16 | -3.5 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4092477 | 158735 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 1034 | 20 | 15 | 16 | -3.5 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL65339 | 218350 | None | 0 | Mouse | Functional | pEC50 | = | 5.0 | 5.0 | -1 | 3 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010061n | |||||
90643825 | 111812 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 923 | 10 | 3 | 5 | 4.1 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287331 | 111812 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 923 | 10 | 3 | 5 | 4.1 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
44394657 | 127531 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 4 | 3 | ChEMBL | 745 | 19 | 10 | 7 | 0.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL366040 | 127531 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 4 | 3 | ChEMBL | 745 | 19 | 10 | 7 | 0.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
137647538 | 158054 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -891 | 4 | ChEMBL | 1680 | 20 | 21 | 21 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4084765 | 158054 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -891 | 4 | ChEMBL | 1680 | 20 | 21 | 21 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
137638725 | 157071 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 3 | 3 | ChEMBL | 1728 | 21 | 21 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4073016 | 157071 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 3 | 3 | ChEMBL | 1728 | 21 | 21 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
90643844 | 111830 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 695 | 10 | 4 | 6 | 2.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287351 | 111830 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 695 | 10 | 4 | 6 | 2.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
44372942 | 119821 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -6 | 2 | ChEMBL | 786 | 22 | 11 | 9 | -1.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
CHEMBL347864 | 119821 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -6 | 2 | ChEMBL | 786 | 22 | 11 | 9 | -1.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
45487417 | 199500 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -27 | 3 | ChEMBL | 617 | 17 | 8 | 7 | 0.1 | COc1ccc(/C=C/C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)cc1 | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL567233 | 199500 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -27 | 3 | ChEMBL | 617 | 17 | 8 | 7 | 0.1 | COc1ccc(/C=C/C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)cc1 | 10.1016/j.bmcl.2009.07.025 | |||
46885559 | 7812 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 492 | 4 | 1 | 5 | 4.0 | C[C@H]1CN(C(=O)[C@H]2CN(c3cncnc3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL1089484 | 7812 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 492 | 4 | 1 | 5 | 4.0 | C[C@H]1CN(C(=O)[C@H]2CN(c3cncnc3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
73347133 | 89506 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -7 | 2 | ChEMBL | 960 | 13 | 10 | 9 | 0.9 | CCCCC(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2c3ccccc3CN2C1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL2371903 | 89506 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -7 | 2 | ChEMBL | 960 | 13 | 10 | 9 | 0.9 | CCCCC(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2c3ccccc3CN2C1=O | 10.1016/s0960-894x(03)00114-8 | |||
44416122 | 80159 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 576 | 11 | 4 | 5 | 1.7 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCNC(N)=O)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL213284 | 80159 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 576 | 11 | 4 | 5 | 1.7 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCNC(N)=O)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
56679964 | 63693 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 599 | 4 | 1 | 3 | 6.6 | CNC(=O)C(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801096 | 63693 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 599 | 4 | 1 | 3 | 6.6 | CNC(=O)C(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
25129105 | 177124 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 12 | 3 | ChEMBL | 623 | 11 | 2 | 5 | 3.9 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1 | 10.1021/jm800525p | |||
CHEMBL463047 | 177124 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 12 | 3 | ChEMBL | 623 | 11 | 2 | 5 | 3.9 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1 | 10.1021/jm800525p | |||
168273822 | 190679 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -7 | 4 | ChEMBL | 1106 | 17 | 13 | 12 | 1.5 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.1c01848 | |||
CHEMBL5180152 | 190679 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -7 | 4 | ChEMBL | 1106 | 17 | 13 | 12 | 1.5 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.1c01848 | |||
11328898 | 7962 | None | 25 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 85 | 4 | ChEMBL | 470 | 3 | 1 | 3 | 4.8 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL1090488 | 7962 | None | 25 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 85 | 4 | ChEMBL | 470 | 3 | 1 | 3 | 4.8 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL1204059 | 7962 | None | 25 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 85 | 4 | ChEMBL | 470 | 3 | 1 | 3 | 4.8 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
122179552 | 121551 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 3 | ChEMBL | 699 | 19 | 10 | 7 | 0.0 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CC(N)=O)Cc1c[nH]c2ccccc12 | 10.1021/acsmedchemlett.5b00053 | |||
CHEMBL3582446 | 121551 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 3 | ChEMBL | 699 | 19 | 10 | 7 | 0.0 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CC(N)=O)Cc1c[nH]c2ccccc12 | 10.1021/acsmedchemlett.5b00053 | |||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL438596 | 216242 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm050780s | |||||
CHEMBL184870 | 211510 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 3 | 3 | ChEMBL | None | None | None | C=CCNC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||||
11786860 | 66355 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 614 | 9 | 4 | 6 | 3.4 | CC(N[C@H]1CCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL185035 | 66355 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 614 | 9 | 4 | 6 | 3.4 | CC(N[C@H]1CCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
71454491 | 78984 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 615 | 10 | 1 | 6 | 3.2 | CN1CCC(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCN(c3ccccc3N(CC3CC3)S(C)(=O)=O)CC2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL2113006 | 78984 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 615 | 10 | 1 | 6 | 3.2 | CN1CCC(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCN(c3ccccc3N(CC3CC3)S(C)(=O)=O)CC2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
44441642 | 154494 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 75 | 3 | ChEMBL | 577 | 9 | 2 | 7 | 3.5 | CC(C)CC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL398816 | 154494 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 75 | 3 | ChEMBL | 577 | 9 | 2 | 7 | 3.5 | CC(C)CC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
162670951 | 182944 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 4 | 2 | ChEMBL | 1100 | 18 | 14 | 11 | 0.6 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL4791306 | 182944 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 4 | 2 | ChEMBL | 1100 | 18 | 14 | 11 | 0.6 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
137644225 | 158528 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 1083 | 22 | 13 | 16 | -1.4 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4090425 | 158528 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 1083 | 22 | 13 | 16 | -1.4 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL501679 | 216631 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -1 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
44277299 | 169535 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 8 | 2 | ChEMBL | 864 | 23 | 9 | 8 | 1.7 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(cccc2OCC)C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL442537 | 169535 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 8 | 2 | ChEMBL | 864 | 23 | 9 | 8 | 1.7 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(cccc2OCC)C1 | 10.1016/s0960-894x(02)00830-2 | |||
145976863 | 163853 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -6 | 4 | ChEMBL | 879 | 11 | 12 | 9 | -0.3 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL4205548 | 163853 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -6 | 4 | ChEMBL | 879 | 11 | 12 | 9 | -0.3 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
90643838 | 111823 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 831 | 10 | 3 | 5 | 4.1 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287345 | 111823 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 831 | 10 | 3 | 5 | 4.1 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
1324 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00318-4 | |||||
16154396 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00318-4 | |||||
16197727 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00318-4 | |||||
16197727.0 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00318-4 | |||||
44285019 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00318-4 | |||||
57514683 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00318-4 | |||||
91898441 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00318-4 | |||||
CHEMBL441738 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00318-4 | |||||
DB04931 | 302 | None | 19 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 8 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(03)00318-4 | |||||
44397655 | 67328 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 627 | 10 | 2 | 8 | 5.7 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(C#N)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL188360 | 67328 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 627 | 10 | 2 | 8 | 5.7 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(C#N)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
10168556 | 63894 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 657 | 9 | 3 | 6 | 4.2 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)c2ccccc2)CC1)[C@@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL180366 | 63894 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 657 | 9 | 3 | 6 | 4.2 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)c2ccccc2)CC1)[C@@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2005.01.060 | |||
137641398 | 158408 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -162 | 4 | ChEMBL | 1694 | 20 | 20 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4089162 | 158408 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -162 | 4 | ChEMBL | 1694 | 20 | 20 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
44448479 | 155461 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 9 | 3 | ChEMBL | 573 | 6 | 1 | 3 | 7.3 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL403420 | 155461 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 9 | 3 | ChEMBL | 573 | 6 | 1 | 3 | 7.3 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
44442977 | 93867 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 537 | 8 | 1 | 5 | 4.8 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ccccn4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL247636 | 93867 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 537 | 8 | 1 | 5 | 4.8 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ccccn4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
44443020 | 94142 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 566 | 9 | 1 | 5 | 5.4 | COc1cccc(CNCC2(N3CCN(C(=O)[C@H]4CN(C(C)C)C[C@@H]4c4ccc(Cl)cc4)CC3)CCCCC2)c1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL249065 | 94142 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 566 | 9 | 1 | 5 | 5.4 | COc1cccc(CNCC2(N3CCN(C(=O)[C@H]4CN(C(C)C)C[C@@H]4c4ccc(Cl)cc4)CC3)CCCCC2)c1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL264190 | 213067 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -30 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
71456245 | 79007 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | 2 | 4 | ChEMBL | 608 | 9 | 2 | 6 | 6.2 | COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)C2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL2113039 | 79007 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | 2 | 4 | ChEMBL | 608 | 9 | 2 | 6 | 6.2 | COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)C2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
44394694 | 66333 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 819 | 21 | 9 | 6 | 3.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL184895 | 66333 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 819 | 21 | 9 | 6 | 3.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL50056 | 216607 | None | 1 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | -117 | 6 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.5b00053 | |||||
44394580 | 122214 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 4 | 3 | ChEMBL | 757 | 19 | 8 | 6 | 2.0 | CC(C)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL359701 | 122214 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 4 | 3 | ChEMBL | 757 | 19 | 8 | 6 | 2.0 | CC(C)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
46944097 | 71942 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 441 | 6 | 1 | 5 | 5.3 | COc1ccc(-c2cc(NC=O)c3ncc(-c4cccc(C(F)(F)F)c4)n3c2)cc1OC | nan | |||
CHEMBL1971975 | 71942 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 441 | 6 | 1 | 5 | 5.3 | COc1ccc(-c2cc(NC=O)c3ncc(-c4cccc(C(F)(F)F)c4)n3c2)cc1OC | nan | |||
CHEMBL3287059 | 213757 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
137644225 | 158528 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1083 | 22 | 13 | 16 | -1.4 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4090425 | 158528 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1083 | 22 | 13 | 16 | -1.4 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
45487296 | 199781 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -10 | 3 | ChEMBL | 635 | 18 | 8 | 7 | 0.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccc(F)cc1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL568836 | 199781 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -10 | 3 | ChEMBL | 635 | 18 | 8 | 7 | 0.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccc(F)cc1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL3287061 | 213759 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
46228764 | 202680 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -35 | 2 | ChEMBL | 525 | 7 | 1 | 4 | 4.6 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)[C@H](Cc2n[nH]c3cc(F)ccc23)C1=O)c1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL596804 | 202680 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -35 | 2 | ChEMBL | 525 | 7 | 1 | 4 | 4.6 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)[C@H](Cc2n[nH]c3cc(F)ccc23)C1=O)c1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
46885816 | 7908 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 28 | 2 | ChEMBL | 436 | 4 | 1 | 3 | 4.4 | CCC[C@]1(O)[C@@H](C)CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@H]1C | 10.1021/jm9017866 | |||
CHEMBL1090161 | 7908 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 28 | 2 | ChEMBL | 436 | 4 | 1 | 3 | 4.4 | CCC[C@]1(O)[C@@H](C)CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@H]1C | 10.1021/jm9017866 | |||
CHEMBL2323800 | 211985 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | -79 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)[C@]23CCCN2C(=O)[C@@H](CSCC3=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||||
45487411 | 199501 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -46 | 3 | ChEMBL | 603 | 16 | 9 | 7 | -0.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(O)c1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL567240 | 199501 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -46 | 3 | ChEMBL | 603 | 16 | 9 | 7 | -0.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(O)c1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
44278193 | 168540 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 22 | 2 | ChEMBL | 862 | 22 | 9 | 7 | 2.4 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(cccc2C(C)C)C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL434966 | 168540 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 22 | 2 | ChEMBL | 862 | 22 | 9 | 7 | 2.4 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(cccc2C(C)C)C1 | 10.1016/s0960-894x(02)00830-2 | |||
9808801 | 60829 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 29 | 4 | ChEMBL | 599 | 8 | 3 | 4 | 5.0 | CC[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1 | 10.1016/j.bmcl.2011.02.090 | |||
CHEMBL1761871 | 60829 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 29 | 4 | ChEMBL | 599 | 8 | 3 | 4 | 5.0 | CC[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1 | 10.1016/j.bmcl.2011.02.090 | |||
10077258 | 15037 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 15 | 4 | ChEMBL | 596 | 8 | 0 | 5 | 4.5 | CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)S(C)(=O)=O | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209253 | 15037 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 15 | 4 | ChEMBL | 596 | 8 | 0 | 5 | 4.5 | CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)S(C)(=O)=O | 10.1016/j.bmcl.2010.06.038 | |||
118735100 | 118864 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 26 | 4 | ChEMBL | 764 | 15 | 9 | 6 | 1.8 | CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(F)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O | 10.1021/ml500436s | |||
CHEMBL3421677 | 118864 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 26 | 4 | ChEMBL | 764 | 15 | 9 | 6 | 1.8 | CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(F)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O | 10.1021/ml500436s | |||
162670951 | 182944 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 4 | 2 | ChEMBL | 1100 | 18 | 14 | 11 | 0.6 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL4791306 | 182944 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 4 | 2 | ChEMBL | 1100 | 18 | 14 | 11 | 0.6 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL3287329 | 213770 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL3287329 | 213770 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL451423 | 216431 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
44373198 | 52182 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 7 | 2 | ChEMBL | 848 | 22 | 10 | 8 | 0.1 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
CHEMBL158808 | 52182 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 7 | 2 | ChEMBL | 848 | 22 | 10 | 8 | 0.1 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
10213106 | 72450 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 199 | 2 | ChEMBL | 892 | 24 | 9 | 8 | 2.9 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccc(OCC)cc2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
CHEMBL198772 | 72450 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 199 | 2 | ChEMBL | 892 | 24 | 9 | 8 | 2.9 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccc(OCC)cc2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
71449119 | 78999 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 117 | 2 | ChEMBL | 643 | 7 | 3 | 6 | 4.2 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CNCCN2C(=O)OC(C)(C)C)CC1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL2113028 | 78999 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 117 | 2 | ChEMBL | 643 | 7 | 3 | 6 | 4.2 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CNCCN2C(=O)OC(C)(C)C)CC1 | 10.1016/j.bmcl.2004.10.020 | |||
44323032 | 209062 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -6 | 3 | ChEMBL | 761 | 20 | 10 | 7 | 0.8 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL89004 | 209062 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -6 | 3 | ChEMBL | 761 | 20 | 10 | 7 | 0.8 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
11308957 | 69415 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -6 | 3 | ChEMBL | 868 | 31 | 9 | 7 | 4.5 | CCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL193151 | 69415 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -6 | 3 | ChEMBL | 868 | 31 | 9 | 7 | 4.5 | CCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
44448631 | 95123 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -1 | 4 | ChEMBL | 619 | 6 | 1 | 3 | 7.0 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL255286 | 95123 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -1 | 4 | ChEMBL | 619 | 6 | 1 | 3 | 7.0 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
44400428 | 125744 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -16 | 3 | ChEMBL | 896 | 35 | 9 | 7 | 6.1 | CCCCCCCCCCCCCCCCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL364726 | 125744 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -16 | 3 | ChEMBL | 896 | 35 | 9 | 7 | 6.1 | CCCCCCCCCCCCCCCCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL264190 | 213067 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.5b01894 | |||||
44394585 | 66787 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 61 | 3 | ChEMBL | 755 | 20 | 9 | 6 | 2.1 | C=CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL185868 | 66787 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 61 | 3 | ChEMBL | 755 | 20 | 9 | 6 | 2.1 | C=CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL5077095 | 216967 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -25 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL204310 | 211623 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -64 | 4 | ChEMBL | None | None | None | CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm0510326 | |||||
44278223 | 99189 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 5 | 2 | ChEMBL | 878 | 23 | 9 | 8 | 2.1 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(cccc2OC(C)C)C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL281060 | 99189 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 5 | 2 | ChEMBL | 878 | 23 | 9 | 8 | 2.1 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(cccc2OC(C)C)C1 | 10.1016/s0960-894x(02)00830-2 | |||
44277301 | 100910 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 3 | 2 | ChEMBL | 854 | 21 | 9 | 7 | 2.0 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(Cl)cccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL29349 | 100910 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 3 | 2 | ChEMBL | 854 | 21 | 9 | 7 | 2.0 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(Cl)cccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
145972289 | 164615 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -45 | 3 | ChEMBL | 915 | 11 | 12 | 9 | 0.5 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL4214826 | 164615 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -45 | 3 | ChEMBL | 915 | 11 | 12 | 9 | 0.5 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
90643806 | 111809 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287326 | 111809 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
59149264 | 76830 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1946 | 57 | 23 | 26 | -3.0 | CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
70684624 | 76830 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1946 | 57 | 23 | 26 | -3.0 | CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
91929810 | 76830 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1946 | 57 | 23 | 26 | -3.0 | CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
CHEMBL2069317 | 76830 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1946 | 57 | 23 | 26 | -3.0 | CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
46885862 | 8473 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 462 | 3 | 1 | 3 | 4.3 | C[C@H]1CN(C(=O)[C@@H]2CN(C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(Cl)cc1 | 10.1021/jm9017866 | |||
CHEMBL1093857 | 8473 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 462 | 3 | 1 | 3 | 4.3 | C[C@H]1CN(C(=O)[C@@H]2CN(C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(Cl)cc1 | 10.1021/jm9017866 | |||
CHEMBL2323793 | 211978 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -17 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||||
137644449 | 158384 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -3 | 3 | ChEMBL | 1016 | 12 | 11 | 10 | -0.7 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4088980 | 158384 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -3 | 3 | ChEMBL | 1016 | 12 | 11 | 10 | -0.7 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
44404528 | 72533 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 10 | 2 | ChEMBL | 791 | 20 | 8 | 6 | 3.3 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL199037 | 72533 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 10 | 2 | ChEMBL | 791 | 20 | 8 | 6 | 3.3 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
44404528 | 72533 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 10 | 2 | ChEMBL | 791 | 20 | 8 | 6 | 3.3 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
CHEMBL199037 | 72533 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 10 | 2 | ChEMBL | 791 | 20 | 8 | 6 | 3.3 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
44448436 | 95655 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 577 | 6 | 1 | 3 | 6.6 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2cc(F)c(F)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL257770 | 95655 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 577 | 6 | 1 | 3 | 6.6 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2cc(F)c(F)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
44443015 | 94099 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 570 | 8 | 1 | 4 | 6.1 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ccccc4Cl)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL248862 | 94099 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 570 | 8 | 1 | 4 | 6.1 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ccccc4Cl)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
44443031 | 154646 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 572 | 8 | 1 | 4 | 5.7 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ccc(F)cc4F)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL399112 | 154646 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 572 | 8 | 1 | 4 | 5.7 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ccc(F)cc4F)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL2323797 | 211982 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | -67 | 3 | ChEMBL | None | None | None | C[C@H]1CN2C(=O)CSC[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)CSSC[C@@H](C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2Cc2c[nH]c3ccccc23)C(=O)N1 | 10.1021/jm301253y | |||||
155555217 | 174441 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | -812 | 3 | ChEMBL | 775 | 16 | 8 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4550976 | 174441 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | -812 | 3 | ChEMBL | 775 | 16 | 8 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
162667982 | 182521 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 776 | 16 | 8 | 7 | -0.1 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)O | 10.1021/acsmedchemlett.0c00561 | |||
CHEMBL4785727 | 182521 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 776 | 16 | 8 | 7 | -0.1 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)O | 10.1021/acsmedchemlett.0c00561 | |||
11364343 | 119988 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 516 | 6 | 2 | 4 | 3.7 | Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
CHEMBL349427 | 119988 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 516 | 6 | 2 | 4 | 3.7 | Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
CHEMBL184968 | 211511 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 7 | 3 | ChEMBL | None | None | None | CCC(=O)OC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||||
145980198 | 166781 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 692 | 17 | 7 | 6 | 2.7 | CCCC[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2018.04.021 | |||
CHEMBL4282109 | 166781 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 692 | 17 | 7 | 6 | 2.7 | CCCC[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2018.04.021 | |||
164622453 | 186196 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | -2 | 3 | ChEMBL | 601 | 12 | 3 | 3 | 6.2 | CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2 | 10.1021/acs.jmedchem.0c02041 | |||
CHEMBL4871577 | 186196 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | -2 | 3 | ChEMBL | 601 | 12 | 3 | 3 | 6.2 | CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2 | 10.1021/acs.jmedchem.0c02041 | |||
162669632 | 182671 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL4787753 | 182671 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
44310243 | 169290 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -2 | 3 | ChEMBL | 1421 | 24 | 20 | 20 | -4.6 | C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm0303608 | |||
91932909 | 169290 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -2 | 3 | ChEMBL | 1421 | 24 | 20 | 20 | -4.6 | C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm0303608 | |||
CHEMBL440633 | 169290 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -2 | 3 | ChEMBL | 1421 | 24 | 20 | 20 | -4.6 | C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm0303608 | |||
44394734 | 64578 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 4 | 3 | ChEMBL | 791 | 19 | 9 | 6 | 2.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL181494 | 64578 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 4 | 3 | ChEMBL | 791 | 19 | 9 | 6 | 2.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
162669632 | 182671 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL4787753 | 182671 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL434357 | 216113 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 5 | 3 | ChEMBL | None | None | None | COP(=O)(N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)OC | 10.1016/j.bmcl.2004.07.046 | |||||
46232220 | 203511 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | -3 | 3 | ChEMBL | 835 | 12 | 9 | 8 | -0.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
CHEMBL602652 | 203511 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | -3 | 3 | ChEMBL | 835 | 12 | 9 | 8 | -0.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
45487407 | 199424 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -8 | 3 | ChEMBL | 617 | 17 | 8 | 7 | 0.1 | COc1ccccc1/C=C/C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCCNC(=N)N)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL566545 | 199424 | None | 0 | Mouse | Functional | pEC50 | = | 4.9 | 4.9 | -8 | 3 | ChEMBL | 617 | 17 | 8 | 7 | 0.1 | COc1ccccc1/C=C/C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCCNC(=N)N)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
122184636 | 122501 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -7 | 4 | ChEMBL | 1116 | 17 | 11 | 11 | 1.1 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||
CHEMBL3600917 | 122501 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -7 | 4 | ChEMBL | 1116 | 17 | 11 | 11 | 1.1 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||
44393888 | 127150 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 625 | 10 | 3 | 6 | 4.9 | CC(NCc1ccco1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL365636 | 127150 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 625 | 10 | 3 | 6 | 4.9 | CC(NCc1ccco1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
44408253 | 140431 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 54 | 4 | ChEMBL | 650 | 10 | 2 | 5 | 6.1 | CCOC(=O)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)C(C)C | 10.1016/j.bmcl.2005.11.095 | |||
CHEMBL380727 | 140431 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 54 | 4 | ChEMBL | 650 | 10 | 2 | 5 | 6.1 | CCOC(=O)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)C(C)C | 10.1016/j.bmcl.2005.11.095 | |||
52940633 | 18158 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 624 | 4 | 0 | 5 | 7.5 | Cc1nc(C(C)(C)C2CC3(CCN(C(=O)[C@@H]4CN(C(C)(C)C)C[C@H]4c4ccc(F)cc4F)CC3)c3cc(Cl)c(C)cc32)no1 | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL1269570 | 18158 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 624 | 4 | 0 | 5 | 7.5 | Cc1nc(C(C)(C)C2CC3(CCN(C(=O)[C@@H]4CN(C(C)(C)C)C[C@H]4c4ccc(F)cc4F)CC3)c3cc(Cl)c(C)cc32)no1 | 10.1016/j.bmcl.2010.09.049 | |||
11846669 | 80308 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 2 | 3 | ChEMBL | 584 | 12 | 5 | 5 | 3.5 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1 | 10.1021/jm060384p | |||
CHEMBL213956 | 80308 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 2 | 3 | ChEMBL | 584 | 12 | 5 | 5 | 3.5 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1 | 10.1021/jm060384p | |||
44413930 | 138735 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 6 | 3 | ChEMBL | 678 | 15 | 5 | 6 | 3.6 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL377620 | 138735 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 6 | 3 | ChEMBL | 678 | 15 | 5 | 6 | 3.6 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
90643805 | 111808 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287325 | 111808 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
90643802 | 111805 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287322 | 111805 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
10325955 | 165366 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 112 | 2 | ChEMBL | 582 | 8 | 2 | 6 | 3.7 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2ccnc2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
CHEMBL423101 | 165366 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 112 | 2 | ChEMBL | 582 | 8 | 2 | 6 | 3.7 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2ccnc2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
11157584 | 168347 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 587 | 10 | 2 | 5 | 4.3 | CCN(CC)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
CHEMBL433710 | 168347 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 587 | 10 | 2 | 5 | 4.3 | CCN(CC)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
44394730 | 132555 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 42 | 3 | ChEMBL | 772 | 21 | 10 | 7 | 0.3 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CNC=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL369770 | 132555 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 42 | 3 | ChEMBL | 772 | 21 | 10 | 7 | 0.3 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CNC=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
11181928 | 166252 | None | 0 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | -4 | 3 | ChEMBL | 797 | 26 | 9 | 7 | 2.5 | CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL426282 | 166252 | None | 0 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | -4 | 3 | ChEMBL | 797 | 26 | 9 | 7 | 2.5 | CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL3799094 | 214728 | None | 0 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | -12 | 4 | ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.5b01894 | |||||
44394660 | 67075 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 41 | 3 | ChEMBL | 772 | 20 | 9 | 7 | 0.2 | NC(=O)CC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL187167 | 67075 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 41 | 3 | ChEMBL | 772 | 20 | 9 | 7 | 0.2 | NC(=O)CC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44322958 | 107068 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -2 | 3 | ChEMBL | 727 | 18 | 9 | 7 | 0.4 | CC(C)(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL315356 | 107068 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -2 | 3 | ChEMBL | 727 | 18 | 9 | 7 | 0.4 | CC(C)(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL3350396 | 213938 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -60 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm960845e | |||||
44415972 | 79914 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 141 | 3 | ChEMBL | 549 | 13 | 6 | 5 | 0.9 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL212332 | 79914 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 141 | 3 | ChEMBL | 549 | 13 | 6 | 5 | 0.9 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2006.05.087 | |||
155556954 | 174652 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -467 | 3 | ChEMBL | 692 | 15 | 8 | 7 | 0.0 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4556149 | 174652 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -467 | 3 | ChEMBL | 692 | 15 | 8 | 7 | 0.0 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
11262020 | 120331 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 612 | 9 | 2 | 7 | 3.7 | Cn1ccnc1COc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
CHEMBL352457 | 120331 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 612 | 9 | 2 | 7 | 3.7 | Cn1ccnc1COc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
73351850 | 89553 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 2 | ChEMBL | 781 | 22 | 9 | 8 | -0.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
CHEMBL2373212 | 89553 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 2 | ChEMBL | 781 | 22 | 9 | 8 | -0.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
44433475 | 148977 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 514 | 7 | 1 | 4 | 5.2 | CC(C)CN1C[C@@H](C(=O)N2CCN(c3c(F)cccc3[C@@H](N)C(C)C)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2007.09.079 | |||
CHEMBL394160 | 148977 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 514 | 7 | 1 | 4 | 5.2 | CC(C)CN1C[C@@H](C(=O)N2CCN(c3c(F)cccc3[C@@H](N)C(C)C)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2007.09.079 | |||
CHEMBL502300 | 216640 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -27 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C1=O | 10.1021/jm801300c | |||||
71459937 | 79006 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 622 | 9 | 2 | 6 | 6.6 | COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@@H]3CCNC[C@H]3c3ccc(F)cc3)C2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL2113038 | 79006 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 622 | 9 | 2 | 6 | 6.6 | COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@@H]3CCNC[C@H]3c3ccc(F)cc3)C2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
44409206 | 140271 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 567 | 13 | 4 | 4 | 4.8 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)[C@H](CC[C@H]1Cc2ccccc2CN1)Cc1ccccc1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL380437 | 140271 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 567 | 13 | 4 | 4 | 4.8 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)[C@H](CC[C@H]1Cc2ccccc2CN1)Cc1ccccc1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL309213 | 213474 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | 1 | 2 | ChEMBL | None | None | None | CCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)00459-6 | |||||
11214733 | 120360 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 530 | 7 | 2 | 4 | 4.0 | CCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
CHEMBL352677 | 120360 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 530 | 7 | 2 | 4 | 4.0 | CCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
122184914 | 122625 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -51 | 4 | ChEMBL | 1144 | 17 | 9 | 11 | 1.8 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O | 10.1021/acs.jmedchem.5b00102 | |||
CHEMBL3601432 | 122625 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -51 | 4 | ChEMBL | 1144 | 17 | 9 | 11 | 1.8 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O | 10.1021/acs.jmedchem.5b00102 | |||
CHEMBL359765 | 214267 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 3 | ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)Nc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||||
44393822 | 124110 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 668 | 9 | 2 | 6 | 4.5 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CN2CCC(N3CCCC3)CC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL363074 | 124110 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 668 | 9 | 2 | 6 | 4.5 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CN2CCC(N3CCCC3)CC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
46203216 | 8478 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 460 | 4 | 1 | 3 | 4.1 | CCN1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccc(F)cc3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1 | 10.1021/jm9017866 | |||
CHEMBL1093889 | 8478 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 460 | 4 | 1 | 3 | 4.1 | CCN1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccc(F)cc3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1 | 10.1021/jm9017866 | |||
CHEMBL1204067 | 8478 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 460 | 4 | 1 | 3 | 4.1 | CCN1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccc(F)cc3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1 | 10.1021/jm9017866 | |||
137658158 | 159811 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -10 | 4 | ChEMBL | 1714 | 21 | 22 | 21 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4104465 | 159811 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -10 | 4 | ChEMBL | 1714 | 21 | 22 | 21 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
45487406 | 199350 | None | 0 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | -12 | 3 | ChEMBL | 605 | 16 | 8 | 6 | 0.3 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccccc1F)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL566150 | 199350 | None | 0 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | -12 | 3 | ChEMBL | 605 | 16 | 8 | 6 | 0.3 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccccc1F)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
44408388 | 140410 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 36 | 4 | ChEMBL | 646 | 8 | 2 | 5 | 5.6 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CCC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2005.11.095 | |||
CHEMBL380635 | 140410 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 36 | 4 | ChEMBL | 646 | 8 | 2 | 5 | 5.6 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CCC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2005.11.095 | |||
49862376 | 15046 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 624 | 8 | 0 | 6 | 5.2 | CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1ncccn1 | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209319 | 15046 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 624 | 8 | 0 | 6 | 5.2 | CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1ncccn1 | 10.1016/j.bmcl.2010.06.038 | |||
44275192 | 168985 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 1066 | 13 | 11 | 9 | 1.6 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3c(Br)cccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL438286 | 168985 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 1066 | 13 | 11 | 9 | 1.6 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3c(Br)cccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
90643806 | 111809 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287326 | 111809 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
59149255 | 76956 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 1960 | 58 | 24 | 26 | -2.5 | CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
70693082 | 76956 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 1960 | 58 | 24 | 26 | -2.5 | CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
91929809 | 76956 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 1960 | 58 | 24 | 26 | -2.5 | CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
CHEMBL2070252 | 76956 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 1960 | 58 | 24 | 26 | -2.5 | CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
46885480 | 7756 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 4 | 3 | ChEMBL | 491 | 4 | 1 | 4 | 4.6 | C[C@H]1CN(C(=O)[C@H]2CN(c3ccccn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL1089103 | 7756 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 4 | 3 | ChEMBL | 491 | 4 | 1 | 4 | 4.6 | C[C@H]1CN(C(=O)[C@H]2CN(c3ccccn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
46885621 | 7957 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 506 | 3 | 1 | 3 | 5.1 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)c(F)c1 | 10.1021/jm9017866 | |||
CHEMBL1090473 | 7957 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 506 | 3 | 1 | 3 | 5.1 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)c(F)c1 | 10.1021/jm9017866 | |||
CHEMBL1204057 | 7957 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 506 | 3 | 1 | 3 | 5.1 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)c(F)c1 | 10.1021/jm9017866 | |||
90643815 | 111782 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 707 | 15 | 8 | 6 | 1.1 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287066 | 111782 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 707 | 15 | 8 | 6 | 1.1 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||
90643843 | 111829 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 809 | 13 | 5 | 6 | 2.6 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287350 | 111829 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 809 | 13 | 5 | 6 | 2.6 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287352 | 213773 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||||
44405879 | 141321 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 946 | 20 | 9 | 7 | 3.8 | CCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc2C(N)=O)CCc2c(Br)cccc2C1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL382930 | 141321 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 946 | 20 | 9 | 7 | 3.8 | CCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc2C(N)=O)CCc2c(Br)cccc2C1 | 10.1016/j.bmcl.2005.08.083 | |||
44405794 | 161940 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 975 | 21 | 10 | 7 | 4.0 | CCCCNC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc2C(N)=O)CCc2c(Br)cccc2C1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL414670 | 161940 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 975 | 21 | 10 | 7 | 4.0 | CCCCNC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc2C(N)=O)CCc2c(Br)cccc2C1 | 10.1016/j.bmcl.2005.08.083 | |||
10030530 | 17606 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 552 | 10 | 1 | 4 | 4.8 | CCN(C(C)=O)C(C)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)NC2CCC2)Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL125819 | 17606 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 552 | 10 | 1 | 4 | 4.8 | CCN(C(C)=O)C(C)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)NC2CCC2)Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
44393864 | 66217 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 642 | 9 | 4 | 6 | 4.4 | CC(N[C@H]1CCCCC1N)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL184405 | 66217 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 642 | 9 | 4 | 6 | 4.4 | CC(N[C@H]1CCCCC1N)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
10030530 | 17606 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 552 | 10 | 1 | 4 | 4.8 | CCN(C(C)=O)C(C)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)NC2CCC2)Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2003.10.056 | |||
CHEMBL125819 | 17606 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 552 | 10 | 1 | 4 | 4.8 | CCN(C(C)=O)C(C)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)NC2CCC2)Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2003.10.056 | |||
44413536 | 140016 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 4 | 2 | ChEMBL | 753 | 10 | 10 | 7 | 1.2 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)CCCCCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
CHEMBL379959 | 140016 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 4 | 2 | ChEMBL | 753 | 10 | 10 | 7 | 1.2 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)CCCCCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
145971389 | 164728 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -15 | 4 | ChEMBL | 851 | 11 | 12 | 9 | -1.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL4216242 | 164728 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -15 | 4 | ChEMBL | 851 | 11 | 12 | 9 | -1.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
44457043 | 97665 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 4 | ChEMBL | 883 | 12 | 10 | 8 | 0.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm701093y | |||
CHEMBL270923 | 97665 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 4 | ChEMBL | 883 | 12 | 10 | 8 | 0.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm701093y | |||
137654884 | 158689 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -3 | 3 | ChEMBL | 840 | 9 | 10 | 9 | -1.4 | C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4092082 | 158689 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -3 | 3 | ChEMBL | 840 | 9 | 10 | 9 | -1.4 | C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O | 10.1021/acs.jmedchem.6b01707 | |||
155542040 | 173181 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -758 | 3 | ChEMBL | 654 | 14 | 7 | 6 | 0.7 | CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4519837 | 173181 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -758 | 3 | ChEMBL | 654 | 14 | 7 | 6 | 0.7 | CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C | 10.1021/acs.jmedchem.9b00053 | |||
44394584 | 96623 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 5 | 3 | ChEMBL | 797 | 19 | 9 | 6 | 2.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CC(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL263047 | 96623 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 5 | 3 | ChEMBL | 797 | 19 | 9 | 6 | 2.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CC(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
11387898 | 56064 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 608 | 9 | 2 | 5 | 5.0 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2OCc2ccccc2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
CHEMBL162493 | 56064 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 608 | 9 | 2 | 5 | 5.0 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2OCc2ccccc2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
11237928 | 164966 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 532 | 7 | 3 | 5 | 2.9 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CO)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
CHEMBL422027 | 164966 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 532 | 7 | 3 | 5 | 2.9 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CO)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
44401313 | 12291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 2 | ChEMBL | 571 | 8 | 4 | 5 | 3.3 | CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1 | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL1184856 | 12291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 2 | ChEMBL | 571 | 8 | 4 | 5 | 3.3 | CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1 | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL2028956 | 12291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 2 | ChEMBL | 571 | 8 | 4 | 5 | 3.3 | CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1 | 10.1016/j.bmcl.2005.02.068 | |||
44397633 | 126448 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 636 | 10 | 2 | 7 | 6.5 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(Cl)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL365051 | 126448 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 636 | 10 | 2 | 7 | 6.5 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(Cl)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
44442997 | 93975 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 576 | 8 | 1 | 4 | 6.3 | O=C([C@H]1CN(C2CCCCC2)C[C@@H]1c1ccc(Cl)cc1)N1CCN(C2(CNCc3ccccc3)CCCCC2)CC1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL248205 | 93975 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 576 | 8 | 1 | 4 | 6.3 | O=C([C@H]1CN(C2CCCCC2)C[C@@H]1c1ccc(Cl)cc1)N1CCN(C2(CNCc3ccccc3)CCCCC2)CC1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL320157 | 213685 | None | 0 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -1 | 3 | ChEMBL | None | None | None | CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.9b00198 | |||||
44447818 | 95463 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 613 | 6 | 2 | 5 | 5.1 | Cc1ccc(N2CCN(C(=O)[C@@H]3[C@@H](c4ccc(Cl)cc4)CCN3C(=O)[C@H]3Cc4ccccc4CN3)CC2)c([C@@H](N)C(C)C)c1 | 10.1016/j.bmcl.2008.01.125 | |||
CHEMBL256956 | 95463 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 613 | 6 | 2 | 5 | 5.1 | Cc1ccc(N2CCN(C(=O)[C@@H]3[C@@H](c4ccc(Cl)cc4)CCN3C(=O)[C@H]3Cc4ccccc4CN3)CC2)c([C@@H](N)C(C)C)c1 | 10.1016/j.bmcl.2008.01.125 | |||
44441686 | 97297 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 545 | 8 | 3 | 5 | 2.7 | CCC(C)(C)C1(C(=O)NC(C)(C)C)CCN(C(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H]2CN(C)CCN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL268722 | 97297 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 545 | 8 | 3 | 5 | 2.7 | CCC(C)(C)C1(C(=O)NC(C)(C)C)CCN(C(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H]2CN(C)CCN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
11592389 | 201848 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -6 | 2 | ChEMBL | 591 | 8 | 1 | 5 | 5.4 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(OC(F)(F)F)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL591037 | 201848 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -6 | 2 | ChEMBL | 591 | 8 | 1 | 5 | 5.4 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(OC(F)(F)F)cc1 | 10.1016/j.bmc.2010.01.049 | |||
45487404 | 199892 | None | 0 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | -3019 | 4 | ChEMBL | 603 | 18 | 8 | 6 | 0.4 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL569694 | 199892 | None | 0 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | -3019 | 4 | ChEMBL | 603 | 18 | 8 | 6 | 0.4 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
122184575 | 122493 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -2 | 4 | ChEMBL | 1102 | 17 | 12 | 11 | 0.8 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||
CHEMBL3600836 | 122493 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -2 | 4 | ChEMBL | 1102 | 17 | 12 | 11 | 0.8 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||
122184909 | 122620 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 6 | 4 | ChEMBL | 1130 | 17 | 10 | 11 | 1.5 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||
CHEMBL3601427 | 122620 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 6 | 4 | ChEMBL | 1130 | 17 | 10 | 11 | 1.5 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||
44413879 | 138989 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -50 | 3 | ChEMBL | 681 | 15 | 6 | 7 | 0.9 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL378293 | 138989 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -50 | 3 | ChEMBL | 681 | 15 | 6 | 7 | 0.9 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N | 10.1021/jm060384p | |||
11851038 | 140422 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 497 | 6 | 0 | 5 | 5.2 | CN(C)[C@H]1C[C@@H](C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1021/jm050780s | |||
CHEMBL380691 | 140422 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 497 | 6 | 0 | 5 | 5.2 | CN(C)[C@H]1C[C@@H](C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1021/jm050780s | |||
CHEMBL433296 | 216097 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -2 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010061n | |||||
44394582 | 168477 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 2 | 3 | ChEMBL | 771 | 21 | 8 | 6 | 2.5 | CCCCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL434544 | 168477 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 2 | 3 | ChEMBL | 771 | 21 | 8 | 6 | 2.5 | CCCCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44448698 | 94985 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 591 | 6 | 1 | 3 | 7.5 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2Cl)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL254351 | 94985 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 591 | 6 | 1 | 3 | 7.5 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2Cl)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
90643842 | 111827 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 714 | 12 | 6 | 6 | 1.5 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287349 | 111827 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 714 | 12 | 6 | 6 | 1.5 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44441648 | 154781 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 41 | 3 | ChEMBL | 605 | 8 | 2 | 8 | 2.9 | Cn1nnnc1CC1(C2CCOCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL399715 | 154781 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 41 | 3 | ChEMBL | 605 | 8 | 2 | 8 | 2.9 | Cn1nnnc1CC1(C2CCOCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
122184637 | 122502 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -4 | 4 | ChEMBL | 1116 | 17 | 11 | 11 | 1.1 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O | 10.1021/acs.jmedchem.5b00102 | |||
CHEMBL3600918 | 122502 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -4 | 4 | ChEMBL | 1116 | 17 | 11 | 11 | 1.1 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O | 10.1021/acs.jmedchem.5b00102 | |||
44413577 | 139613 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -5 | 2 | ChEMBL | 711 | 10 | 10 | 7 | 0.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
CHEMBL379531 | 139613 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -5 | 2 | ChEMBL | 711 | 10 | 10 | 7 | 0.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
46885325 | 8318 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 432 | 3 | 2 | 3 | 3.4 | C[C@H]1CN(C(=O)[C@@H]2CNC[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cccc(F)c1 | 10.1021/jm9017866 | |||
CHEMBL1092733 | 8318 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 432 | 3 | 2 | 3 | 3.4 | C[C@H]1CN(C(=O)[C@@H]2CNC[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cccc(F)c1 | 10.1021/jm9017866 | |||
44394626 | 65805 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 12 | 3 | ChEMBL | 743 | 19 | 8 | 6 | 1.7 | CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL183476 | 65805 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 12 | 3 | ChEMBL | 743 | 19 | 8 | 6 | 1.7 | CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44310259 | 161794 | None | 0 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | 1 | 2 | ChEMBL | 1421 | 24 | 20 | 20 | -4.6 | C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O | 10.1021/jm0303608 | |||
91932914 | 161794 | None | 0 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | 1 | 2 | ChEMBL | 1421 | 24 | 20 | 20 | -4.6 | C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O | 10.1021/jm0303608 | |||
CHEMBL413465 | 161794 | None | 0 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | 1 | 2 | ChEMBL | 1421 | 24 | 20 | 20 | -4.6 | C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O | 10.1021/jm0303608 | |||
CHEMBL413573 | 215535 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -30 | 4 | ChEMBL | None | None | None | CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](C(C)C)NC1=O | 10.1021/jm0510326 | |||||
44408252 | 140756 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 30 | 4 | ChEMBL | 605 | 8 | 3 | 4 | 4.3 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCNC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2005.11.095 | |||
CHEMBL381503 | 140756 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 30 | 4 | ChEMBL | 605 | 8 | 3 | 4 | 4.3 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCNC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2005.11.095 | |||
44408189 | 168982 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 32 | 4 | ChEMBL | 619 | 8 | 2 | 4 | 4.6 | CN1CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)C1=O | 10.1016/j.bmcl.2005.11.095 | |||
CHEMBL438259 | 168982 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 32 | 4 | ChEMBL | 619 | 8 | 2 | 4 | 4.6 | CN1CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)C1=O | 10.1016/j.bmcl.2005.11.095 | |||
10373417 | 100859 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 301 | 2 | ChEMBL | 863 | 22 | 9 | 8 | 1.4 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(cccc2N(C)C)C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL29317 | 100859 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 301 | 2 | ChEMBL | 863 | 22 | 9 | 8 | 1.4 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(cccc2N(C)C)C1 | 10.1016/s0960-894x(02)00830-2 | |||
44444495 | 155005 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 595 | 10 | 1 | 5 | 5.2 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1 | 10.1016/j.bmcl.2007.10.115 | |||
CHEMBL400932 | 155005 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 595 | 10 | 1 | 5 | 5.2 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1 | 10.1016/j.bmcl.2007.10.115 | |||
9867330 | 97894 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 14 | 3 | ChEMBL | 429 | 6 | 1 | 5 | 3.7 | N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1 | 10.1016/j.bmcl.2007.11.109 | |||
CHEMBL272099 | 97894 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 14 | 3 | ChEMBL | 429 | 6 | 1 | 5 | 3.7 | N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1 | 10.1016/j.bmcl.2007.11.109 | |||
44444495 | 155005 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 595 | 10 | 1 | 5 | 5.2 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL400932 | 155005 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 595 | 10 | 1 | 5 | 5.2 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1 | 10.1016/j.bmcl.2007.06.088 | |||
44444497 | 155102 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 571 | 9 | 2 | 5 | 4.3 | CNCC(=O)N[C@H](c1cccc(F)c1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1)C(C)C | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL401465 | 155102 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 571 | 9 | 2 | 5 | 4.3 | CNCC(=O)N[C@H](c1cccc(F)c1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1)C(C)C | 10.1016/j.bmcl.2007.06.088 | |||
9960253 | 117013 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 25 | 2 | ChEMBL | 595 | 8 | 3 | 6 | 2.8 | CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
CHEMBL338594 | 117013 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 25 | 2 | ChEMBL | 595 | 8 | 3 | 6 | 2.8 | CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
71456236 | 78921 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -31 | 2 | ChEMBL | 814 | 24 | 10 | 9 | -0.3 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc(OCC)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
CHEMBL2112918 | 78921 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -31 | 2 | ChEMBL | 814 | 24 | 10 | 9 | -0.3 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc(OCC)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
6918813 | 131439 | None | 2 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 77 | 4 | ChEMBL | 557 | 7 | 3 | 5 | 2.9 | CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL368876 | 131439 | None | 2 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 77 | 4 | ChEMBL | 557 | 7 | 3 | 5 | 2.9 | CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2004.10.020 | |||
44413535 | 96758 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 4 | 2 | ChEMBL | 738 | 10 | 9 | 7 | 2.9 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC[C@H](Cc2c[nH]cn2)NC(=O)CCCCCCCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
CHEMBL264120 | 96758 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 4 | 2 | ChEMBL | 738 | 10 | 9 | 7 | 2.9 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC[C@H](Cc2c[nH]cn2)NC(=O)CCCCCCCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
44322977 | 111632 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -2 | 3 | ChEMBL | 714 | 18 | 11 | 8 | -1.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL328117 | 111632 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -2 | 3 | ChEMBL | 714 | 18 | 11 | 8 | -1.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
168271237 | 190597 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -69 | 4 | ChEMBL | 2788 | 45 | 36 | 36 | 0.1 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5179081 | 190597 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -69 | 4 | ChEMBL | 2788 | 45 | 36 | 36 | 0.1 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
155563222 | 175395 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -524 | 3 | ChEMBL | 711 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4572994 | 175395 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -524 | 3 | ChEMBL | 711 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
155564058 | 175438 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -794 | 3 | ChEMBL | 746 | 14 | 7 | 6 | 0.7 | CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4574056 | 175438 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -794 | 3 | ChEMBL | 746 | 14 | 7 | 6 | 0.7 | CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C | 10.1021/acs.jmedchem.9b00053 | |||
90643844 | 111830 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 695 | 10 | 4 | 6 | 2.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287351 | 111830 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 695 | 10 | 4 | 6 | 2.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
44409140 | 141373 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 675 | 16 | 6 | 5 | 3.5 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@@H]1Cc2ccccc2CN1)Cc1ccccc1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL383256 | 141373 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 675 | 16 | 6 | 5 | 3.5 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@@H]1Cc2ccccc2CN1)Cc1ccccc1 | 10.1016/j.bmcl.2005.12.005 | |||
44405425 | 71884 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 669 | 10 | 3 | 5 | 4.5 | NC1(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCN(C3(CNC(=O)Cc4ccccc4)CCCCC3)CC2)CCc2ccccc2C1 | 10.1016/j.bmcl.2005.08.061 | |||
CHEMBL197020 | 71884 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 669 | 10 | 3 | 5 | 4.5 | NC1(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCN(C3(CNC(=O)Cc4ccccc4)CCCCC3)CC2)CCc2ccccc2C1 | 10.1016/j.bmcl.2005.08.061 | |||
44443033 | 93751 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 584 | 9 | 1 | 5 | 5.5 | COc1ccc(CNCC2(N3CCN(C(=O)[C@H]4CN(C(C)C)C[C@@H]4c4ccc(Cl)cc4)CC3)CCCCC2)c(F)c1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL247010 | 93751 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 584 | 9 | 1 | 5 | 5.5 | COc1ccc(CNCC2(N3CCN(C(=O)[C@H]4CN(C(C)C)C[C@@H]4c4ccc(Cl)cc4)CC3)CCCCC2)c(F)c1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL264190 | 213067 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -30 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
155556466 | 174520 | None | 0 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -2238 | 3 | ChEMBL | 648 | 17 | 8 | 6 | 1.2 | CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(C)C | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4552764 | 174520 | None | 0 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -2238 | 3 | ChEMBL | 648 | 17 | 8 | 6 | 1.2 | CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(C)C | 10.1021/acs.jmedchem.9b00053 | |||
44349151 | 18537 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 603 | 7 | 3 | 7 | 2.5 | COC(=O)C(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL127461 | 18537 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 603 | 7 | 3 | 7 | 2.5 | COC(=O)C(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/s0960-894x(03)00796-0 | |||
44413842 | 138464 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -3 | 3 | ChEMBL | 587 | 14 | 5 | 6 | 1.3 | NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL377210 | 138464 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -3 | 3 | ChEMBL | 587 | 14 | 5 | 6 | 1.3 | NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
44394010 | 125492 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 599 | 9 | 3 | 5 | 4.5 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNC2CCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL364577 | 125492 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 599 | 9 | 3 | 5 | 4.5 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNC2CCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
10188529 | 126849 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 19 | 3 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | CN1C[C@H]2CC[C@@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2 | 10.1016/j.bmcl.2005.05.109 | |||
CHEMBL365401 | 126849 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 19 | 3 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | CN1C[C@H]2CC[C@@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2 | 10.1016/j.bmcl.2005.05.109 | |||
46228846 | 201849 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 8 | 2 | ChEMBL | 567 | 9 | 1 | 6 | 4.3 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)C(Cc3n[nH]c4ccccc34)(OC)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL591041 | 201849 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 8 | 2 | ChEMBL | 567 | 9 | 1 | 6 | 4.3 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)C(Cc3n[nH]c4ccccc34)(OC)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
25133903 | 170661 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 596 | 11 | 3 | 6 | 3.1 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNc2ccccn2)C1=O | 10.1021/jm800525p | |||
CHEMBL445009 | 170661 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 596 | 11 | 3 | 6 | 3.1 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNc2ccccn2)C1=O | 10.1021/jm800525p | |||
CHEMBL420581 | 215711 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -27 | 2 | ChEMBL | None | None | None | CCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)00459-6 | |||||
44394093 | 127306 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 3 | 3 | ChEMBL | 881 | 19 | 9 | 6 | 3.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL365825 | 127306 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 3 | 3 | ChEMBL | 881 | 19 | 9 | 6 | 3.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44456138 | 95406 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 609 | 8 | 2 | 6 | 4.4 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)[C@@H](C)N)C(C)C)c1 | 10.1016/j.bmcl.2007.10.115 | |||
CHEMBL256686 | 95406 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 609 | 8 | 2 | 6 | 4.4 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)[C@@H](C)N)C(C)C)c1 | 10.1016/j.bmcl.2007.10.115 | |||
145989222 | 167376 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 4 | ChEMBL | 676 | 17 | 7 | 6 | 2.2 | CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2018.04.021 | |||
CHEMBL4293365 | 167376 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 4 | ChEMBL | 676 | 17 | 7 | 6 | 2.2 | CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2018.04.021 | |||
44413932 | 137633 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 3 | 3 | ChEMBL | 570 | 12 | 5 | 5 | 3.1 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1 | 10.1021/jm060384p | |||
CHEMBL375440 | 137633 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 3 | 3 | ChEMBL | 570 | 12 | 5 | 5 | 3.1 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1 | 10.1021/jm060384p | |||
CHEMBL3287329 | 213770 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL3287064 | 213762 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL264190 | 213067 | None | 0 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | -2 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2003.08.078 | |||||
49862742 | 14976 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 601 | 4 | 0 | 5 | 6.1 | CC(C)(C#N)[C@H]1OC2(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(F)c(Cl)cc21 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1208802 | 14976 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 601 | 4 | 0 | 5 | 6.1 | CC(C)(C#N)[C@H]1OC2(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(F)c(Cl)cc21 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL264190 | 213067 | None | 0 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | -2 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010524p | |||||
137662147 | 159473 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 25 | 3 | ChEMBL | 1051 | 19 | 15 | 15 | -3.0 | C[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4100598 | 159473 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 25 | 3 | ChEMBL | 1051 | 19 | 15 | 15 | -3.0 | C[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
11555886 | 155724 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 6 | 1 | 3 | 6.4 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL404696 | 155724 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 6 | 1 | 3 | 6.4 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
44443035 | 154506 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 584 | 9 | 1 | 5 | 5.5 | COc1ccc(CNCC2(N3CCN(C(=O)[C@H]4CN(C(C)C)C[C@@H]4c4ccc(Cl)cc4)CC3)CCCCC2)cc1F | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL398929 | 154506 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 584 | 9 | 1 | 5 | 5.5 | COc1ccc(CNCC2(N3CCN(C(=O)[C@H]4CN(C(C)C)C[C@@H]4c4ccc(Cl)cc4)CC3)CCCCC2)cc1F | 10.1016/j.bmcl.2007.10.032 | |||
44444493 | 155220 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 581 | 9 | 1 | 5 | 4.8 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CN(C)C)C(C)C)c1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL402058 | 155220 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 581 | 9 | 1 | 5 | 4.8 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CN(C)C)C(C)C)c1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL432201 | 216094 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 6 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
57817730 | 76951 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 1919 | 56 | 24 | 26 | -3.5 | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
70684622 | 76951 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 1919 | 56 | 24 | 26 | -3.5 | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
91929805 | 76951 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 1919 | 56 | 24 | 26 | -3.5 | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
CHEMBL2070247 | 76951 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 1919 | 56 | 24 | 26 | -3.5 | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
137648053 | 157631 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -10 | 3 | ChEMBL | 934 | 12 | 11 | 10 | -1.5 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4080169 | 157631 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -10 | 3 | ChEMBL | 934 | 12 | 11 | 10 | -1.5 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
44349093 | 168625 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 633 | 8 | 2 | 7 | 4.2 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2c(Cn3cncn3)ccc3ccccc23)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL435410 | 168625 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 633 | 8 | 2 | 7 | 4.2 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2c(Cn3cncn3)ccc3ccccc23)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL439128 | 216286 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -52 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O | 10.1021/jm030119t | |||||
10141778 | 116783 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 500 | 9 | 2 | 6 | 3.2 | NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1 | 10.1016/j.bmcl.2003.09.036 | |||
CHEMBL337351 | 116783 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 500 | 9 | 2 | 6 | 3.2 | NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1 | 10.1016/j.bmcl.2003.09.036 | |||
46232228 | 203480 | None | 0 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -5 | 3 | ChEMBL | 863 | 12 | 8 | 8 | 1.0 | N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
CHEMBL602299 | 203480 | None | 0 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -5 | 3 | ChEMBL | 863 | 12 | 8 | 8 | 1.0 | N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
171378343 | 196422 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -8 | 4 | ChEMBL | 697 | 15 | 10 | 7 | -0.2 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CNC1=O | 10.1021/acs.jmedchem.2c01794 | |||
CHEMBL5423711 | 196422 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -8 | 4 | ChEMBL | 697 | 15 | 10 | 7 | -0.2 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CNC1=O | 10.1021/acs.jmedchem.2c01794 | |||
45487413 | 199707 | None | 0 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | -14 | 3 | ChEMBL | 616 | 15 | 10 | 7 | -0.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1cc2cc(O)ccc2[nH]1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL568409 | 199707 | None | 0 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | -14 | 3 | ChEMBL | 616 | 15 | 10 | 7 | -0.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1cc2cc(O)ccc2[nH]1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
44358915 | 13082 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL1190181 | 13082 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL540320 | 13082 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
137653925 | 158699 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -4 | 4 | ChEMBL | 1742 | 21 | 20 | 21 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4092141 | 158699 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -4 | 4 | ChEMBL | 1742 | 21 | 20 | 21 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL263822 | 213049 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -16 | 4 | ChEMBL | None | None | None | CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC1=O | 10.1021/jm0510326 | |||||
44393886 | 66380 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 585 | 9 | 3 | 5 | 4.2 | CC(NC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL185145 | 66380 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 585 | 9 | 3 | 5 | 4.2 | CC(NC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
44275264 | 156472 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 1066 | 13 | 11 | 9 | 1.6 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3cccc(Br)c3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL406636 | 156472 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 1066 | 13 | 11 | 9 | 1.6 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3cccc(Br)c3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
44441689 | 154507 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 569 | 7 | 3 | 6 | 1.8 | CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3C=CC(=O)CC3)CC2)C1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL398932 | 154507 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 569 | 7 | 3 | 6 | 1.8 | CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3C=CC(=O)CC3)CC2)C1 | 10.1016/j.bmcl.2006.11.084 | |||
15953838 | 67291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 18 | 3 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL188146 | 67291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 18 | 3 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL539306 | 67291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 18 | 3 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
11635265 | 202942 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -12 | 2 | ChEMBL | 543 | 7 | 1 | 4 | 4.8 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3cc(F)ccc23)C1=O)c1ccc(F)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL598617 | 202942 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -12 | 2 | ChEMBL | 543 | 7 | 1 | 4 | 4.8 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3cc(F)ccc23)C1=O)c1ccc(F)cc1 | 10.1016/j.bmc.2010.01.049 | |||
44335147 | 4594 | None | 0 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -4 | 3 | ChEMBL | 711 | 16 | 9 | 7 | -0.3 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NC1(C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1 | 10.1021/jm010524p | |||
CHEMBL102688 | 4594 | None | 0 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -4 | 3 | ChEMBL | 711 | 16 | 9 | 7 | -0.3 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NC1(C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1 | 10.1021/jm010524p | |||
CHEMBL275303 | 213280 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | 4 | 4 | ChEMBL | None | None | None | CC(=O)N1Cc2ccccc2C[C@@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
11555886 | 155724 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 6 | 1 | 3 | 6.4 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1 | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL404696 | 155724 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 6 | 1 | 3 | 6.4 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1 | 10.1016/j.bmcl.2010.09.049 | |||
10483153 | 60831 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 53 | 4 | ChEMBL | 571 | 6 | 3 | 4 | 4.2 | C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1 | 10.1016/j.bmcl.2011.02.090 | |||
CHEMBL1761873 | 60831 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 53 | 4 | ChEMBL | 571 | 6 | 3 | 4 | 4.2 | C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1 | 10.1016/j.bmcl.2011.02.090 | |||
44416014 | 80046 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 562 | 10 | 4 | 5 | 1.3 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(N)=O)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL212855 | 80046 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 562 | 10 | 4 | 5 | 1.3 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(N)=O)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
11555886 | 155724 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 6 | 1 | 3 | 6.4 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL404696 | 155724 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 6 | 1 | 3 | 6.4 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1 | 10.1016/j.bmcl.2010.06.062 | |||
145976444 | 164058 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -6 | 4 | ChEMBL | 889 | 11 | 12 | 9 | -0.1 | CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL4207858 | 164058 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -6 | 4 | ChEMBL | 889 | 11 | 12 | 9 | -0.1 | CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
46885712 | 8073 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 63 | 4 | ChEMBL | 488 | 3 | 1 | 3 | 4.9 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1 | 10.1021/jm9017866 | |||
CHEMBL1091151 | 8073 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 63 | 4 | ChEMBL | 488 | 3 | 1 | 3 | 4.9 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1 | 10.1021/jm9017866 | |||
CHEMBL1204061 | 8073 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 63 | 4 | ChEMBL | 488 | 3 | 1 | 3 | 4.9 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1 | 10.1021/jm9017866 | |||
46885417 | 8283 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 498 | 4 | 1 | 4 | 4.2 | C[C@H]1CN(C(=O)[C@H]2CN(C3CCOCC3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL1092573 | 8283 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 498 | 4 | 1 | 4 | 4.2 | C[C@H]1CN(C(=O)[C@H]2CN(C3CCOCC3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
44456964 | 156782 | None | 0 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 3 | ChEMBL | 849 | 12 | 10 | 8 | 0.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm701093y | |||
CHEMBL406985 | 156782 | None | 0 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 3 | ChEMBL | 849 | 12 | 10 | 8 | 0.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm701093y | |||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
10145026 | 12273 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 585 | 8 | 4 | 5 | 3.5 | CC(C)C1CNC[C@@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)N1 | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL1184727 | 12273 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 585 | 8 | 4 | 5 | 3.5 | CC(C)C1CNC[C@@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)N1 | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL2028962 | 12273 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 585 | 8 | 4 | 5 | 3.5 | CC(C)C1CNC[C@@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)N1 | 10.1016/j.bmcl.2005.02.068 | |||
44393885 | 124454 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 628 | 8 | 3 | 6 | 3.6 | C[C@H]1CN(Cc2ccccc2N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)[C@@H](C)CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL363925 | 124454 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 628 | 8 | 3 | 6 | 3.6 | C[C@H]1CN(Cc2ccccc2N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)[C@@H](C)CN1 | 10.1016/j.bmcl.2004.06.059 | |||
44390421 | 63927 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 645 | 10 | 1 | 6 | 4.8 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cc3ccccc3cn2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL180544 | 63927 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 645 | 10 | 1 | 6 | 4.8 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cc3ccccc3cn2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
44322923 | 209004 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -2 | 3 | ChEMBL | 710 | 19 | 10 | 8 | -0.5 | N#CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL88630 | 209004 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -2 | 3 | ChEMBL | 710 | 19 | 10 | 8 | -0.5 | N#CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
127047913 | 140011 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -19 | 4 | ChEMBL | 962 | 35 | 12 | 13 | -1.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.5b01894 | |||
CHEMBL3799563 | 140011 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -19 | 4 | ChEMBL | 962 | 35 | 12 | 13 | -1.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.5b01894 | |||
CHEMBL370254 | 214626 | None | 2 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -6 | 3 | ChEMBL | None | None | None | NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1 | 10.1021/jm0490843 | |||||
44394735 | 123382 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 34 | 3 | ChEMBL | 797 | 19 | 9 | 7 | 2.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccs1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL361578 | 123382 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 34 | 3 | ChEMBL | 797 | 19 | 9 | 7 | 2.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccs1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44278071 | 100498 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 1 | 2 | ChEMBL | 704 | 20 | 9 | 7 | -0.6 | CCCC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL29056 | 100498 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 1 | 2 | ChEMBL | 704 | 20 | 9 | 7 | -0.6 | CCCC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)00830-2 | |||
49862426 | 15067 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 534 | 6 | 0 | 4 | 4.6 | CC(=O)N(CC(N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)(C)C)C(C)C | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209383 | 15067 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 534 | 6 | 0 | 4 | 4.6 | CC(=O)N(CC(N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)(C)C)C(C)C | 10.1016/j.bmcl.2010.06.038 | |||
15953838 | 67291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 18 | 3 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL188146 | 67291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 18 | 3 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL539306 | 67291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 18 | 3 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL415200 | 215639 | None | 0 | Mouse | Functional | pEC50 | = | 6.8 | 6.8 | -20 | 5 | ChEMBL | None | None | None | C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(CCCN)CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O | 10.1021/jm030452x | |||||
1334 | 1501 | None | 4 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -6 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030119t | |||||
16133814 | 1501 | None | 4 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -6 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030119t | |||||
CHEMBL437050 | 1501 | None | 4 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -6 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030119t | |||||
44442995 | 93705 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 562 | 8 | 1 | 4 | 5.9 | O=C([C@H]1CN(C2CCCC2)C[C@@H]1c1ccc(Cl)cc1)N1CCN(C2(CNCc3ccccc3)CCCCC2)CC1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL246837 | 93705 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 562 | 8 | 1 | 4 | 5.9 | O=C([C@H]1CN(C2CCCC2)C[C@@H]1c1ccc(Cl)cc1)N1CCN(C2(CNCc3ccccc3)CCCCC2)CC1 | 10.1016/j.bmcl.2007.10.032 | |||
11364326 | 66707 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -4 | 2 | ChEMBL | 515 | 6 | 3 | 3 | 5.2 | C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1 | 10.1021/jm0400496 | |||
CHEMBL185455 | 66707 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -4 | 2 | ChEMBL | 515 | 6 | 3 | 3 | 5.2 | C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1 | 10.1021/jm0400496 | |||
168285101 | 191753 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -85 | 4 | ChEMBL | 1347 | 15 | 14 | 15 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccccc2CSCC[C@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5195937 | 191753 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -85 | 4 | ChEMBL | 1347 | 15 | 14 | 15 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccccc2CSCC[C@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.2c00793 | |||
45487415 | 199895 | None | 0 | Mouse | Functional | pEC50 | = | 4.7 | 4.7 | -218 | 3 | ChEMBL | 603 | 16 | 9 | 7 | -0.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(O)cc1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL569697 | 199895 | None | 0 | Mouse | Functional | pEC50 | = | 4.7 | 4.7 | -218 | 3 | ChEMBL | 603 | 16 | 9 | 7 | -0.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(O)cc1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
44413913 | 138760 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 1 | 3 | ChEMBL | 672 | 16 | 6 | 7 | 0.2 | CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL377779 | 138760 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 1 | 3 | ChEMBL | 672 | 16 | 6 | 7 | 0.2 | CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N | 10.1021/jm060384p | |||
137643023 | 158402 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 1010 | 16 | 13 | 14 | -1.1 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)CCC[C@H](N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4089119 | 158402 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 1010 | 16 | 13 | 14 | -1.1 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)CCC[C@H](N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
44394787 | 166083 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 4 | 3 | ChEMBL | 821 | 21 | 9 | 7 | 2.6 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)COc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL425348 | 166083 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 4 | 3 | ChEMBL | 821 | 21 | 9 | 7 | 2.6 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)COc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
90643819 | 111783 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 688 | 13 | 6 | 6 | 1.8 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287070 | 111783 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 688 | 13 | 6 | 6 | 1.8 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||
44441633 | 94583 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 18 | 2 | ChEMBL | 546 | 7 | 2 | 4 | 5.2 | N#CCC1(C2CCCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL251735 | 94583 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 18 | 2 | ChEMBL | 546 | 7 | 2 | 4 | 5.2 | N#CCC1(C2CCCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
44456137 | 155211 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 609 | 9 | 2 | 6 | 4.2 | CNCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@@H]2CN(C3CCOCC3)C[C@H]2c2ccc(Cl)cc2)CC1)C(C)C | 10.1016/j.bmcl.2007.10.115 | |||
CHEMBL402017 | 155211 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 609 | 9 | 2 | 6 | 4.2 | CNCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@@H]2CN(C3CCOCC3)C[C@H]2c2ccc(Cl)cc2)CC1)C(C)C | 10.1016/j.bmcl.2007.10.115 | |||
49862377 | 15047 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 13 | 4 | ChEMBL | 654 | 9 | 0 | 6 | 6.2 | CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cnn(C(C)C)c1 | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209320 | 15047 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 13 | 4 | ChEMBL | 654 | 9 | 0 | 6 | 6.2 | CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cnn(C(C)C)c1 | 10.1016/j.bmcl.2010.06.038 | |||
49862425 | 15066 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 74 | 4 | ChEMBL | 570 | 9 | 0 | 5 | 4.0 | CC(C)CC(CN(C(C)C)S(C)(=O)=O)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1 | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209382 | 15066 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 74 | 4 | ChEMBL | 570 | 9 | 0 | 5 | 4.0 | CC(C)CC(CN(C(C)C)S(C)(=O)=O)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1 | 10.1016/j.bmcl.2010.06.038 | |||
49862478 | 15081 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 570 | 7 | 0 | 5 | 4.0 | CC(C)N(CC(N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)(C)C)S(C)(=O)=O | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209458 | 15081 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 570 | 7 | 0 | 5 | 4.0 | CC(C)N(CC(N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)(C)C)S(C)(=O)=O | 10.1016/j.bmcl.2010.06.038 | |||
46885366 | 7853 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 456 | 5 | 1 | 3 | 4.4 | CCCN1C[C@H](c2ccc(F)cc2F)[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)C1 | 10.1021/jm9017866 | |||
CHEMBL1089796 | 7853 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 456 | 5 | 1 | 3 | 4.4 | CCCN1C[C@H](c2ccc(F)cc2F)[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)C1 | 10.1021/jm9017866 | |||
11787684 | 70298 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -6 | 3 | ChEMBL | 811 | 27 | 9 | 7 | 2.9 | CCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL194217 | 70298 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -6 | 3 | ChEMBL | 811 | 27 | 9 | 7 | 2.9 | CCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
16132144 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2009.07.025 | |||||
16133793 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2009.07.025 | |||||
44273719 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2009.07.025 | |||||
CHEMBL214332 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2009.07.025 | |||||
137631599 | 156617 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -16 | 4 | ChEMBL | 1694 | 20 | 20 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4067967 | 156617 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -16 | 4 | ChEMBL | 1694 | 20 | 20 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
172446133 | 195506 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 3 | 3 | ChEMBL | 964 | 12 | 12 | 12 | -0.1 | C[C@@H]1NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5405038 | 195506 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 3 | 3 | ChEMBL | 964 | 12 | 12 | 12 | -0.1 | C[C@@H]1NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
44443026 | 154892 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 593 | 9 | 2 | 5 | 5.4 | CC(=O)Nc1ccc(CNCC2(N3CCN(C(=O)[C@H]4CN(C(C)C)C[C@@H]4c4ccc(Cl)cc4)CC3)CCCCC2)cc1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL400263 | 154892 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 593 | 9 | 2 | 5 | 5.4 | CC(=O)Nc1ccc(CNCC2(N3CCN(C(=O)[C@H]4CN(C(C)C)C[C@@H]4c4ccc(Cl)cc4)CC3)CCCCC2)cc1 | 10.1016/j.bmcl.2007.10.032 | |||
90643802 | 111805 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287322 | 111805 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
102096778 | 58823 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | -10 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||
51351277 | 58823 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | -10 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||
53322400 | 58823 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | -10 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||
91932360 | 58823 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | -10 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||
CHEMBL1688111 | 58823 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | -10 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||
CHEMBL2323794 | 211979 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | -21 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||||
44349173 | 117054 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 3 | 3 | ChEMBL | 606 | 6 | 2 | 5 | 3.4 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)c2ccccc21 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL338768 | 117054 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 3 | 3 | ChEMBL | 606 | 6 | 2 | 5 | 3.4 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)c2ccccc21 | 10.1016/s0960-894x(03)00796-0 | |||
44393821 | 66733 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 650 | 11 | 2 | 6 | 4.5 | CN(CCc1ccccn1)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL185583 | 66733 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 650 | 11 | 2 | 6 | 4.5 | CN(CCc1ccccn1)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL3349030 | 213864 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -1 | 3 | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O | 10.1021/jm000211e | |||||
168285904 | 191779 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -117 | 4 | ChEMBL | 1347 | 15 | 14 | 15 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2cccc(c2)CSCC[C@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5196407 | 191779 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -117 | 4 | ChEMBL | 1347 | 15 | 14 | 15 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2cccc(c2)CSCC[C@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.2c00793 | |||
44433380 | 88521 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 564 | 6 | 1 | 4 | 5.3 | CC(=O)N1C[C@@H](C(=O)N2CCN(c3ccc(C(F)(F)F)cc3[C@@H](N)CC(C)C)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2007.09.079 | |||
CHEMBL234992 | 88521 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 564 | 6 | 1 | 4 | 5.3 | CC(=O)N1C[C@@H](C(=O)N2CCN(c3ccc(C(F)(F)F)cc3[C@@H](N)CC(C)C)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2007.09.079 | |||
11341045 | 66187 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -4 | 2 | ChEMBL | 501 | 6 | 3 | 3 | 5.0 | O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCNCC2)cc1 | 10.1021/jm0400496 | |||
CHEMBL184275 | 66187 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -4 | 2 | ChEMBL | 501 | 6 | 3 | 3 | 5.0 | O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCNCC2)cc1 | 10.1021/jm0400496 | |||
44349110 | 18558 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 559 | 7 | 3 | 5 | 3.4 | CC(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL127574 | 18558 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 559 | 7 | 3 | 5 | 3.4 | CC(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL264190 | 213067 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -30 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
45487291 | 199829 | None | 0 | Mouse | Functional | pEC50 | = | 4.7 | 4.7 | -6 | 3 | ChEMBL | 605 | 16 | 8 | 6 | 0.4 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C(F)=C/c1ccccc1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL569220 | 199829 | None | 0 | Mouse | Functional | pEC50 | = | 4.7 | 4.7 | -6 | 3 | ChEMBL | 605 | 16 | 8 | 6 | 0.4 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C(F)=C/c1ccccc1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
44448480 | 95611 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 573 | 6 | 1 | 3 | 7.3 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL257616 | 95611 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 573 | 6 | 1 | 3 | 7.3 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
44409379 | 76549 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 757 | 19 | 6 | 5 | 4.3 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(Cl)cc1)NC(C)=O)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL206018 | 76549 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 757 | 19 | 6 | 5 | 4.3 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(Cl)cc1)NC(C)=O)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2005.12.005 | |||
137647538 | 158054 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -891 | 4 | ChEMBL | 1680 | 20 | 21 | 21 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4084765 | 158054 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -891 | 4 | ChEMBL | 1680 | 20 | 21 | 21 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL3287073 | 213768 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||||
49862662 | 15127 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 569 | 3 | 0 | 4 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209704 | 15127 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 569 | 3 | 0 | 4 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
44441639 | 94103 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 11 | 2 | ChEMBL | 532 | 7 | 2 | 4 | 4.8 | N#CCC1(C2CCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL248893 | 94103 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 11 | 2 | ChEMBL | 532 | 7 | 2 | 4 | 4.8 | N#CCC1(C2CCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
46232222 | 203512 | None | 0 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | -3 | 3 | ChEMBL | 835 | 12 | 8 | 8 | 0.2 | N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
CHEMBL602653 | 203512 | None | 0 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | -3 | 3 | ChEMBL | 835 | 12 | 8 | 8 | 0.2 | N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
90643804 | 111807 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -8 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287324 | 111807 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -8 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
122184634 | 122499 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -2 | 4 | ChEMBL | 1116 | 17 | 11 | 11 | 1.1 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||
CHEMBL3600915 | 122499 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -2 | 4 | ChEMBL | 1116 | 17 | 11 | 11 | 1.1 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||
44456957 | 98091 | None | 0 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | -8 | 2 | ChEMBL | 432 | 5 | 1 | 2 | 5.2 | O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2-c2ccccc2)c2ccccc21 | 10.1021/jm701303z | |||
CHEMBL273044 | 98091 | None | 0 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | -8 | 2 | ChEMBL | 432 | 5 | 1 | 2 | 5.2 | O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2-c2ccccc2)c2ccccc21 | 10.1021/jm701303z | |||
10373417 | 100859 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 301 | 2 | ChEMBL | 863 | 22 | 9 | 8 | 1.4 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(cccc2N(C)C)C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL29317 | 100859 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 301 | 2 | ChEMBL | 863 | 22 | 9 | 8 | 1.4 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(cccc2N(C)C)C1 | 10.1016/s0960-894x(02)00830-2 | |||
137638778 | 156850 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 11 | 3 | ChEMBL | 1053 | 18 | 14 | 15 | -2.4 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4070639 | 156850 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 11 | 3 | ChEMBL | 1053 | 18 | 14 | 15 | -2.4 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
44447251 | 154888 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 531 | 5 | 0 | 4 | 5.4 | CC(C)(C)N1C[C@H](c2ccc(F)cc2F)[C@@H](C(=O)N2CCC(CN3CCOC3=O)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.11.128 | |||
CHEMBL400237 | 154888 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 531 | 5 | 0 | 4 | 5.4 | CC(C)(C)N1C[C@H](c2ccc(F)cc2F)[C@@H](C(=O)N2CCC(CN3CCOC3=O)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.11.128 | |||
127047913 | 140011 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -4 | 4 | ChEMBL | 962 | 35 | 12 | 13 | -1.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL3799563 | 140011 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -4 | 4 | ChEMBL | 962 | 35 | 12 | 13 | -1.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
44415918 | 141636 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 754 | 16 | 6 | 7 | 0.9 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL384774 | 141636 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 754 | 16 | 6 | 7 | 0.9 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2018.04.021 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2018.04.021 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2018.04.021 | |||||
44569175 | 188930 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 12 | 3 | ChEMBL | 629 | 11 | 3 | 5 | 2.5 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCC(=O)N1 | 10.1021/jm800525p | |||
CHEMBL506272 | 188930 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 12 | 3 | ChEMBL | 629 | 11 | 3 | 5 | 2.5 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCC(=O)N1 | 10.1021/jm800525p | |||
172445559 | 195459 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 981 | 17 | 15 | 11 | -0.5 | CCCC[C@H](NC(C)=N)C(=O)N[C@@H]1NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.2c01794 | |||
CHEMBL5404193 | 195459 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 981 | 17 | 15 | 11 | -0.5 | CCCC[C@H](NC(C)=N)C(=O)N[C@@H]1NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.2c01794 | |||
73347133 | 89506 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -7 | 2 | ChEMBL | 960 | 13 | 10 | 9 | 0.9 | CCCCC(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2c3ccccc3CN2C1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL2371903 | 89506 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -7 | 2 | ChEMBL | 960 | 13 | 10 | 9 | 0.9 | CCCCC(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2c3ccccc3CN2C1=O | 10.1016/s0960-894x(03)00114-8 | |||
44275656 | 159562 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 6 | 2 | ChEMBL | 1031 | 15 | 11 | 9 | 1.5 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(C(F)(F)F)cc2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL410148 | 159562 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 6 | 2 | ChEMBL | 1031 | 15 | 11 | 9 | 1.5 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(C(F)(F)F)cc2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL2070242 | 211642 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||||
11753695 | 8395 | None | 6 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | 3 | 7 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.02.058 | |||
CHEMBL1093304 | 8395 | None | 6 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | 3 | 7 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.02.058 | |||
1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -14 | 8 | ChEMBL | None | None | None | None | 10.1021/jm050780s | |||||
44405858 | 72886 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 896 | 21 | 9 | 7 | 4.2 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc2C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL200276 | 72886 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 896 | 21 | 9 | 7 | 4.2 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc2C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
44405833 | 133525 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 877 | 23 | 10 | 7 | 2.6 | CCCCNC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCCC(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL370665 | 133525 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 877 | 23 | 10 | 7 | 2.6 | CCCCNC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCCC(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
44405836 | 135277 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 882 | 21 | 9 | 7 | 2.5 | NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(NC(=O)Cc2ccccc2)CC[C@@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL372200 | 135277 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 882 | 21 | 9 | 7 | 2.5 | NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(NC(=O)Cc2ccccc2)CC[C@@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
44405860 | 136240 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 925 | 22 | 10 | 7 | 4.4 | CCCCNC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc2C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL373259 | 136240 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 925 | 22 | 10 | 7 | 4.4 | CCCCNC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc2C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
9919056 | 141156 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1380 | 2 | ChEMBL | 848 | 22 | 9 | 7 | 2.5 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL382511 | 141156 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1380 | 2 | ChEMBL | 848 | 22 | 9 | 7 | 2.5 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
44405793 | 159037 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 958 | 22 | 10 | 7 | 4.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(NC(=O)Cc2ccccc2)CC[C@@H](c2ccccc2)CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL409588 | 159037 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 958 | 22 | 10 | 7 | 4.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(NC(=O)Cc2ccccc2)CC[C@@H](c2ccccc2)CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2005.08.083 | |||
44405792 | 166205 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 940 | 23 | 10 | 7 | 4.1 | CCCCNC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cccc(C(N)=O)c2)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL425992 | 166205 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 940 | 23 | 10 | 7 | 4.1 | CCCCNC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cccc(C(N)=O)c2)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
44405910 | 170559 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 910 | 22 | 9 | 7 | 3.9 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cccc(C(N)=O)c2)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL444880 | 170559 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 910 | 22 | 9 | 7 | 3.9 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cccc(C(N)=O)c2)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL200614 | 211567 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CCCCNC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||||
CHEMBL434186 | 216112 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CCCCNC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||||
11273288 | 12965 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 61 | 3 | ChEMBL | 585 | 8 | 3 | 5 | 3.6 | CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL1189370 | 12965 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 61 | 3 | ChEMBL | 585 | 8 | 3 | 5 | 3.6 | CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL538567 | 12965 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 61 | 3 | ChEMBL | 585 | 8 | 3 | 5 | 3.6 | CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C | 10.1016/j.bmcl.2005.02.068 | |||
44404526 | 96545 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 346 | 2 | ChEMBL | 878 | 23 | 9 | 8 | 2.5 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2cccc(OC)c2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
CHEMBL262470 | 96545 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 346 | 2 | ChEMBL | 878 | 23 | 9 | 8 | 2.5 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2cccc(OC)c2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
9919056 | 141156 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1380 | 2 | ChEMBL | 848 | 22 | 9 | 7 | 2.5 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
CHEMBL382511 | 141156 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1380 | 2 | ChEMBL | 848 | 22 | 9 | 7 | 2.5 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
CHEMBL3644320 | 214420 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 30 | 2 | ChEMBL | None | None | None | CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O | nan | |||||
CHEMBL3646886 | 214484 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 39 | 2 | ChEMBL | None | None | None | CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1CCCNC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O | nan | |||||
CHEMBL5083551 | 217358 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -10 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2005.11.095 | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2005.11.095 | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2005.11.095 | |||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2007.11.109 | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2007.11.109 | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2007.11.109 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/ml500436s | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/ml500436s | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/ml500436s | |||||
44448629 | 167561 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -3 | 4 | ChEMBL | 619 | 6 | 1 | 3 | 7.0 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL429854 | 167561 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -3 | 4 | ChEMBL | 619 | 6 | 1 | 3 | 7.0 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
46911588 | 63689 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 613 | 4 | 0 | 3 | 7.0 | CC(=O)N(C)C(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801092 | 63689 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 613 | 4 | 0 | 3 | 7.0 | CC(=O)N(C)C(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2011.03.019 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2011.03.019 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2011.03.019 | |||||
44358565 | 30034 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 588 | 8 | 2 | 6 | 5.3 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@H]1CCc2ccccc2N1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL138901 | 30034 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 588 | 8 | 2 | 6 | 5.3 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@H]1CCc2ccccc2N1 | 10.1016/j.bmcl.2003.09.026 | |||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm049579s | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm049579s | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm049579s | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm049579s | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm030111j | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm030111j | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm030111j | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm030111j | |||||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm025539h | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm025539h | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm025539h | |||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm025539h | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm025539h | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm025539h | |||
118722929 | 116296 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O | 10.1021/jm501027w | |||
CHEMBL3358538 | 116296 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O | 10.1021/jm501027w | |||
10101361 | 155793 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 4 | ChEMBL | 717 | 16 | 8 | 6 | 2.4 | CC(=O)Nc1cc2ccccc2cc1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||
CHEMBL405174 | 155793 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 4 | ChEMBL | 717 | 16 | 8 | 6 | 2.4 | CC(=O)Nc1cc2ccccc2cc1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||
CHEMBL5078687 | 217068 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -4 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
168271934 | 190194 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -26 | 4 | ChEMBL | 2229 | 37 | 32 | 26 | -3.7 | C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5172738 | 190194 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -26 | 4 | ChEMBL | 2229 | 37 | 32 | 26 | -3.7 | C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O | 10.1021/acs.jmedchem.2c00793 | |||
52943061 | 18155 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 610 | 4 | 0 | 5 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)CC2C(C)(C)c1nnco1 | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL1269568 | 18155 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 610 | 4 | 0 | 5 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)CC2C(C)(C)c1nnco1 | 10.1016/j.bmcl.2010.09.049 | |||
44416135 | 80215 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 38 | 3 | ChEMBL | 561 | 10 | 5 | 5 | 1.1 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(=N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
CHEMBL213566 | 80215 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 38 | 3 | ChEMBL | 561 | 10 | 5 | 5 | 1.1 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(=N)N)C1=O | 10.1016/j.bmcl.2006.05.087 | |||
44416135 | 80215 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 38 | 3 | ChEMBL | 561 | 10 | 5 | 5 | 1.1 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(=N)N)C1=O | 10.1021/jm800525p | |||
CHEMBL213566 | 80215 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 38 | 3 | ChEMBL | 561 | 10 | 5 | 5 | 1.1 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(=N)N)C1=O | 10.1021/jm800525p | |||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm9017866 | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm9017866 | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm9017866 | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm9017866 | |||||
118722925 | 116293 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -3 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=[N+]=[N-])C(N)=O | 10.1021/jm501027w | |||
CHEMBL3358534 | 116293 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -3 | 3 | ChEMBL | 1052 | 34 | 13 | 11 | 1.6 | CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=[N+]=[N-])C(N)=O | 10.1021/jm501027w | |||
CHEMBL264190 | 213067 | None | 0 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -2 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.07.015 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.07.015 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -33 | 7 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.07.015 | |||||
137662147 | 159473 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 25 | 3 | ChEMBL | 1051 | 19 | 15 | 15 | -3.0 | C[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4100598 | 159473 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 25 | 3 | ChEMBL | 1051 | 19 | 15 | 15 | -3.0 | C[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
52945472 | 18156 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 624 | 4 | 0 | 5 | 7.5 | Cc1nnc(C(C)(C)[C@H]2CC3(CCN(C(=O)[C@@H]4CN(C(C)(C)C)C[C@H]4c4ccc(F)cc4F)CC3)c3cc(Cl)c(C)cc32)o1 | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL1269569 | 18156 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 624 | 4 | 0 | 5 | 7.5 | Cc1nnc(C(C)(C)[C@H]2CC3(CCN(C(=O)[C@@H]4CN(C(C)(C)C)C[C@H]4c4ccc(F)cc4F)CC3)c3cc(Cl)c(C)cc32)o1 | 10.1016/j.bmcl.2010.09.049 | |||
56676635 | 63708 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 669 | 5 | 1 | 4 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NC1CCOCC1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801127 | 63708 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 669 | 5 | 1 | 4 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NC1CCOCC1 | 10.1016/j.bmcl.2010.06.062 | |||
11845450 | 138556 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -51 | 3 | ChEMBL | 652 | 15 | 5 | 6 | 2.6 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL377465 | 138556 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -51 | 3 | ChEMBL | 652 | 15 | 5 | 6 | 2.6 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
44408286 | 140755 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 117 | 4 | ChEMBL | 634 | 8 | 2 | 5 | 5.5 | CC1(C)COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.11.095 | |||
CHEMBL381501 | 140755 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 117 | 4 | ChEMBL | 634 | 8 | 2 | 5 | 5.5 | CC1(C)COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.11.095 | |||
52941830 | 18162 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 637 | 4 | 0 | 5 | 7.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CCN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)c1ncnn1C | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL1269574 | 18162 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 637 | 4 | 0 | 5 | 7.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CCN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)c1ncnn1C | 10.1016/j.bmcl.2010.09.049 | |||
90643802 | 111805 | None | 0 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -2 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287322 | 111805 | None | 0 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -2 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL2115441 | 211727 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -8 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm960845e | |||||
10078903 | 68041 | None | 0 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -7 | 3 | ChEMBL | 769 | 24 | 9 | 7 | 1.8 | CCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL191303 | 68041 | None | 0 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -7 | 3 | ChEMBL | 769 | 24 | 9 | 7 | 1.8 | CCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
16132144 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm701303z | |||||
16133793 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm701303z | |||||
44273719 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm701303z | |||||
CHEMBL214332 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm701303z | |||||
CHEMBL5085972 | 217492 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -1 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL5090670 | 217767 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 3 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
49862665 | 15130 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 128 | 2 | ChEMBL | 585 | 5 | 1 | 5 | 5.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)CO)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209707 | 15130 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 128 | 2 | ChEMBL | 585 | 5 | 1 | 5 | 5.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)CO)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
90643804 | 111807 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -8 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287324 | 111807 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -8 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
90643841 | 111826 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 828 | 15 | 7 | 6 | 1.9 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287348 | 111826 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 828 | 15 | 7 | 6 | 1.9 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL5087839 | 217610 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 2 | 3 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
44418430 | 83287 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -1 | 3 | ChEMBL | 334 | 4 | 0 | 2 | 3.1 | O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 | 10.1016/j.bmcl.2006.07.015 | |||
CHEMBL218748 | 83287 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -1 | 3 | ChEMBL | 334 | 4 | 0 | 2 | 3.1 | O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 | 10.1016/j.bmcl.2006.07.015 | |||
25133209 | 173455 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 19 | 3 | ChEMBL | 589 | 12 | 3 | 5 | 2.4 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)CNC | 10.1021/jm800525p | |||
CHEMBL452710 | 173455 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 19 | 3 | ChEMBL | 589 | 12 | 3 | 5 | 2.4 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)CNC | 10.1021/jm800525p | |||
46919520 | 15144 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -2 | 6 | ChEMBL | 597 | 4 | 0 | 5 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209788 | 15144 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -2 | 6 | ChEMBL | 597 | 4 | 0 | 5 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
90643804 | 111807 | None | 0 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -2 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287324 | 111807 | None | 0 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | -2 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL5094168 | 217969 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -134 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
137637656 | 156329 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 40 | 3 | ChEMBL | 1045 | 20 | 14 | 15 | -2.2 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4064777 | 156329 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 40 | 3 | ChEMBL | 1045 | 20 | 14 | 15 | -2.2 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
44448660 | 95026 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -4 | 4 | ChEMBL | 575 | 6 | 1 | 3 | 6.9 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL254589 | 95026 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -4 | 4 | ChEMBL | 575 | 6 | 1 | 3 | 6.9 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00488 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00488 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00488 | |||||
90643806 | 111809 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287326 | 111809 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL448536 | 216421 | None | 0 | Mouse | Functional | pEC50 | = | 8.6 | 8.6 | 1 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C#N)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm070461w | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm070461w | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm070461w | |||||
CHEMBL393075 | 214922 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -7 | 4 | ChEMBL | None | None | None | CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1016/j.bmcl.2007.02.020 | |||||
168270124 | 190064 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -20 | 4 | ChEMBL | 2096 | 33 | 32 | 24 | -3.6 | CCCC[C@@H]1NC(=O)[C@@H]2CSCCCSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5170533 | 190064 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -20 | 4 | ChEMBL | 2096 | 33 | 32 | 24 | -3.6 | CCCC[C@@H]1NC(=O)[C@@H]2CSCCCSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm0510326 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm0510326 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm0510326 | |||||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm060768f | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm060768f | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm060768f | |||||
56683296 | 63700 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 627 | 5 | 1 | 3 | 7.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NC(C)C | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801119 | 63700 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 627 | 5 | 1 | 3 | 7.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NC(C)C | 10.1016/j.bmcl.2010.06.062 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm801300c | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm801300c | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/jm801300c | |||||
49862751 | 15159 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 677 | 5 | 0 | 5 | 6.8 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)N1CCC(F)(F)C1 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209802 | 15159 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 677 | 5 | 0 | 5 | 6.8 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)N1CCC(F)(F)C1 | 10.1016/j.bmcl.2010.06.068 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01285 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01285 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01285 | |||||
90643804 | 111807 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -8 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287324 | 111807 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -8 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287327 | 213769 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -5 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
90643803 | 111806 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -3 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287323 | 111806 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -3 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
16132144 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2015.09.046 | |||||
16133793 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2015.09.046 | |||||
44273719 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2015.09.046 | |||||
CHEMBL214332 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2015.09.046 | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44393824 | 122418 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 659 | 13 | 3 | 5 | 5.7 | CCCC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ncc[nH]2)NC(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL359976 | 122418 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 659 | 13 | 3 | 5 | 5.7 | CCCC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ncc[nH]2)NC(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
1338 | 3807 | None | 36 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | 2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm025539h | |||
9938402 | 3807 | None | 36 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | 2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm025539h | |||
CHEMBL339053 | 3807 | None | 36 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | 2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm025539h | |||
CHEMBL410217 | 215268 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 2 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm960845e | |||||
44277696 | 101259 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 4 | ChEMBL | 770 | 22 | 10 | 8 | -0.7 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL29582 | 101259 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 4 | ChEMBL | 770 | 22 | 10 | 8 | -0.7 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)00830-2 | |||
44456027 | 155560 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 599 | 10 | 1 | 5 | 5.0 | CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.10.115 | |||
CHEMBL403967 | 155560 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 599 | 10 | 1 | 5 | 5.0 | CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.10.115 | |||
44413938 | 139026 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 10 | 3 | ChEMBL | 662 | 15 | 4 | 5 | 3.9 | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL378446 | 139026 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 10 | 3 | ChEMBL | 662 | 15 | 4 | 5 | 3.9 | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL3287327 | 213769 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -5 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL2323795 | 211980 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -39 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||||
90643826 | 111813 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287333 | 111813 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
44277696 | 101259 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 4 | ChEMBL | 770 | 22 | 10 | 8 | -0.7 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL29582 | 101259 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 4 | ChEMBL | 770 | 22 | 10 | 8 | -0.7 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/j.bmcl.2005.08.083 | |||
44409339 | 75022 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 723 | 19 | 6 | 5 | 3.7 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccccc1)NC(C)=O)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL203252 | 75022 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 723 | 19 | 6 | 5 | 3.7 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccccc1)NC(C)=O)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL78565 | 218370 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | None | None | None | CCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)00459-6 | |||||
44394693 | 96651 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 2 | 3 | ChEMBL | 805 | 20 | 9 | 6 | 2.8 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL263234 | 96651 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 2 | 3 | ChEMBL | 805 | 20 | 9 | 6 | 2.8 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44373177 | 119895 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 804 | 22 | 10 | 8 | -0.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
CHEMBL348511 | 119895 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 804 | 22 | 10 | 8 | -0.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
44372933 | 119977 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 770 | 22 | 10 | 8 | -0.7 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
CHEMBL349298 | 119977 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 770 | 22 | 10 | 8 | -0.7 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
44277696 | 101259 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 4 | ChEMBL | 770 | 22 | 10 | 8 | -0.7 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/j.bmcl.2005.08.012 | |||
CHEMBL29582 | 101259 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 4 | ChEMBL | 770 | 22 | 10 | 8 | -0.7 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/j.bmcl.2005.08.012 | |||
CHEMBL411400 | 215343 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -141 | 5 | ChEMBL | None | None | None | C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC1(C)C)C(N)=O | 10.1021/jm030452x | |||||
44323031 | 168181 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -39 | 3 | ChEMBL | 775 | 21 | 10 | 7 | 1.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL432565 | 168181 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -39 | 3 | ChEMBL | 775 | 21 | 10 | 7 | 1.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
71452720 | 79002 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 34 | 3 | ChEMBL | 568 | 7 | 3 | 4 | 4.3 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2C[C@H]3CC[C@@H]2NC3)CC1 | 10.1016/j.bmcl.2005.05.109 | |||
CHEMBL2113031 | 79002 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 34 | 3 | ChEMBL | 568 | 7 | 3 | 4 | 4.3 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2C[C@H]3CC[C@@H]2NC3)CC1 | 10.1016/j.bmcl.2005.05.109 | |||
44322812 | 112445 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -5 | 3 | ChEMBL | 711 | 19 | 10 | 7 | 0.0 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C1CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL329586 | 112445 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -5 | 3 | ChEMBL | 711 | 19 | 10 | 7 | 0.0 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C1CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
11491374 | 67641 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -21 | 3 | ChEMBL | 840 | 29 | 9 | 7 | 3.7 | CCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL190366 | 67641 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -21 | 3 | ChEMBL | 840 | 29 | 9 | 7 | 3.7 | CCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL501592 | 216629 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -38 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C1=O | 10.1021/jm801300c | |||||
CHEMBL501642 | 216630 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm801300c | |||||
CHEMBL509582 | 218036 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 6 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm801300c | |||||
44405832 | 133653 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 14 | 2 | ChEMBL | 909 | 21 | 8 | 7 | 2.7 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc2ccc3ccccc3c2)C(=O)NCC(N)=O)CCc2c(Br)cccc2C1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL371215 | 133653 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 14 | 2 | ChEMBL | 909 | 21 | 8 | 7 | 2.7 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc2ccc3ccccc3c2)C(=O)NCC(N)=O)CCc2c(Br)cccc2C1 | 10.1016/j.bmcl.2005.08.083 | |||
11272336 | 57210 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 517 | 6 | 3 | 5 | 3.0 | Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
CHEMBL164969 | 57210 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 517 | 6 | 3 | 5 | 3.0 | Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
44397657 | 124190 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 624 | 10 | 2 | 7 | 5.8 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3F)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL363384 | 124190 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 624 | 10 | 2 | 7 | 5.8 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3F)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL438235 | 216220 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -10 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)CSSC1(C)C | 10.1021/jm030119t | |||||
CHEMBL446185 | 216405 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -5 | 3 | ChEMBL | None | None | None | CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm0510326 | |||||
71459937 | 79006 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 622 | 9 | 2 | 6 | 6.6 | COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@@H]3CCNC[C@H]3c3ccc(F)cc3)C2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL2113038 | 79006 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 622 | 9 | 2 | 6 | 6.6 | COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@@H]3CCNC[C@H]3c3ccc(F)cc3)C2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
44349226 | 117047 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 601 | 10 | 1 | 6 | 2.8 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)N2CCNCC2)Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2003.10.056 | |||
CHEMBL338747 | 117047 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 601 | 10 | 1 | 6 | 2.8 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)N2CCNCC2)Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2003.10.056 | |||
11845444 | 80098 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -11 | 3 | ChEMBL | 678 | 15 | 5 | 6 | 3.6 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL213026 | 80098 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -11 | 3 | ChEMBL | 678 | 15 | 5 | 6 | 3.6 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
44413970 | 139102 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -50 | 3 | ChEMBL | 587 | 14 | 5 | 6 | 1.3 | NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL378571 | 139102 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -50 | 3 | ChEMBL | 587 | 14 | 5 | 6 | 1.3 | NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL2323792 | 211977 | None | 0 | Mouse | Functional | pEC50 | = | 4.7 | 4.7 | -2 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||||
CHEMBL438596 | 216242 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm050780s | |||||
118735103 | 118867 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -1 | 4 | ChEMBL | 698 | 15 | 8 | 9 | -0.8 | CC(=O)N[C@H]1Cn2nncc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O | 10.1021/ml500436s | |||
CHEMBL3421680 | 118867 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -1 | 4 | ChEMBL | 698 | 15 | 8 | 9 | -0.8 | CC(=O)N[C@H]1Cn2nncc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O | 10.1021/ml500436s | |||
90643833 | 111819 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 920 | 15 | 7 | 6 | 1.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287340 | 111819 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 920 | 15 | 7 | 6 | 1.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL566764 | 218243 | None | 0 | Mouse | Functional | pEC50 | = | 4.7 | 4.7 | -2 | 2 | ChEMBL | None | None | None | CC(=O)N/C(=C\c1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCCNC(=N)N)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||||
90643819 | 111783 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 688 | 13 | 6 | 6 | 1.8 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287070 | 111783 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 688 | 13 | 6 | 6 | 1.8 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||
44393889 | 66368 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 667 | 11 | 3 | 5 | 5.5 | CC(NCCc1ccccc1F)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL185094 | 66368 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 667 | 11 | 3 | 5 | 5.5 | CC(NCCc1ccccc1F)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
44393877 | 122319 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 628 | 10 | 4 | 6 | 3.5 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCC2CCNCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL359777 | 122319 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 628 | 10 | 4 | 6 | 3.5 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCC2CCNCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL3287064 | 213762 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(N)=O | 10.1021/jm500064t | |||||
46885524 | 7806 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 186 | 3 | ChEMBL | 458 | 5 | 1 | 5 | 3.6 | CCC[C@]1(O)[C@@H](C)CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@H]1C | 10.1021/jm9017866 | |||
CHEMBL1089462 | 7806 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 186 | 3 | ChEMBL | 458 | 5 | 1 | 5 | 3.6 | CCC[C@]1(O)[C@@H](C)CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@H]1C | 10.1021/jm9017866 | |||
CHEMBL1204054 | 7806 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 186 | 3 | ChEMBL | 458 | 5 | 1 | 5 | 3.6 | CCC[C@]1(O)[C@@H](C)CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@H]1C | 10.1021/jm9017866 | |||
CHEMBL264190 | 213067 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -2 | 7 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.9b00198 | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
CHEMBL3287356 | 213774 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||||
44394691 | 122969 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 15 | 3 | ChEMBL | 792 | 19 | 9 | 7 | 2.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccnc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL360598 | 122969 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 15 | 3 | ChEMBL | 792 | 19 | 9 | 7 | 2.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccnc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
11753667 | 57194 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 596 | 8 | 2 | 6 | 4.0 | Cc1nccn1Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
CHEMBL164857 | 57194 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 596 | 8 | 2 | 6 | 4.0 | Cc1nccn1Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
44441643 | 154890 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 43 | 2 | ChEMBL | 591 | 8 | 2 | 7 | 3.9 | Cn1nnnc1CC1(CC(C)(C)C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL400252 | 154890 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 43 | 2 | ChEMBL | 591 | 8 | 2 | 7 | 3.9 | Cn1nnnc1CC1(CC(C)(C)C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
44323034 | 208988 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 3 | ChEMBL | 729 | 21 | 11 | 8 | -0.6 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL88537 | 208988 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 3 | ChEMBL | 729 | 21 | 11 | 8 | -0.6 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
11263053 | 68042 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -29 | 3 | ChEMBL | 896 | 33 | 9 | 7 | 5.3 | CCCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL191304 | 68042 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -29 | 3 | ChEMBL | 896 | 33 | 9 | 7 | 5.3 | CCCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL88185 | 218386 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 4 | 3 | ChEMBL | None | None | None | CS(=O)(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||||
44444508 | 155172 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 635 | 9 | 2 | 5 | 5.7 | CC(C)C[C@H](NC(=O)[C@H](C)N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL401853 | 155172 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 635 | 9 | 2 | 5 | 5.7 | CC(C)C[C@H](NC(=O)[C@H](C)N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL526334 | 218171 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -1 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O | 10.1021/jm801300c | |||||
CHEMBL3287327 | 213769 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -5 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL2323529 | 211969 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | -2 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||||
11261324 | 58151 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 547 | 7 | 2 | 6 | 3.3 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2[N+](=O)[O-])CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
CHEMBL167780 | 58151 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 547 | 7 | 2 | 6 | 3.3 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2[N+](=O)[O-])CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
44397569 | 122972 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 636 | 10 | 2 | 7 | 6.5 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(Cl)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL360602 | 122972 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 636 | 10 | 2 | 7 | 6.5 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(Cl)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL3600842 | 214279 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -7 | 4 | ChEMBL | None | None | None | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O | 10.1021/acs.jmedchem.5b00102 | |||||
CHEMBL50056 | 216607 | None | 1 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | -117 | 6 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.9b00198 | |||||
44349008 | 114393 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 646 | 10 | 4 | 7 | 3.1 | CCOC(=O)CNC(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL333071 | 114393 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 646 | 10 | 4 | 7 | 3.1 | CCOC(=O)CNC(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/s0960-894x(03)00796-0 | |||
137659949 | 159225 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -1 | 2 | ChEMBL | 3926 | 63 | 56 | 62 | -18.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2[C@H]2CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NC2=O | 10.1021/acs.jmedchem.8b00251 | |||
CHEMBL4097903 | 159225 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -1 | 2 | ChEMBL | 3926 | 63 | 56 | 62 | -18.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2[C@H]2CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NC2=O | 10.1021/acs.jmedchem.8b00251 | |||
52943061 | 18155 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 610 | 4 | 0 | 5 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)CC2C(C)(C)c1nnco1 | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL1269568 | 18155 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 610 | 4 | 0 | 5 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)CC2C(C)(C)c1nnco1 | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL50056 | 216607 | None | 1 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | -117 | 6 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010061n | |||||
16725558 | 155759 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 575 | 6 | 1 | 3 | 6.9 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2Cl)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL404905 | 155759 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 575 | 6 | 1 | 3 | 6.9 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2Cl)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
90643847 | 111832 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 828 | 15 | 7 | 6 | 1.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287354 | 111832 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 828 | 15 | 7 | 6 | 1.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL2369131 | 212052 | None | 0 | Mouse | Functional | pEC50 | = | 4.7 | 4.7 | -5 | 3 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O | 10.1021/jm0492756 | |||||
44441682 | 154738 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 529 | 8 | 3 | 5 | 2.1 | CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(CC3CC3)(C(=O)NC(C)(C)C)CC2)C1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL399474 | 154738 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 529 | 8 | 3 | 5 | 2.1 | CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(CC3CC3)(C(=O)NC(C)(C)C)CC2)C1 | 10.1016/j.bmcl.2006.11.084 | |||
168295131 | 192351 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -14 | 4 | ChEMBL | 1135 | 17 | 13 | 12 | 2.2 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.1c01848 | |||
CHEMBL5205283 | 192351 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -14 | 4 | ChEMBL | 1135 | 17 | 13 | 12 | 2.2 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.1c01848 | |||
CHEMBL3600920 | 214283 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -8 | 4 | ChEMBL | None | None | None | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||||
52918026 | 60828 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 63 | 4 | ChEMBL | 571 | 6 | 3 | 4 | 4.2 | C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1 | 10.1016/j.bmcl.2011.02.090 | |||
CHEMBL1761870 | 60828 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 63 | 4 | ChEMBL | 571 | 6 | 3 | 4 | 4.2 | C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1 | 10.1016/j.bmcl.2011.02.090 | |||
11753695 | 8395 | None | 6 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -10 | 7 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1093304 | 8395 | None | 6 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -10 | 7 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
11753695 | 8395 | None | 6 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -10 | 7 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.02.058 | |||
CHEMBL1093304 | 8395 | None | 6 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | -10 | 7 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.02.058 | |||
90643847 | 111832 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 828 | 15 | 7 | 6 | 1.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287354 | 111832 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 828 | 15 | 7 | 6 | 1.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
44409104 | 76552 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 582 | 12 | 5 | 5 | 2.9 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL206033 | 76552 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 582 | 12 | 5 | 5 | 2.9 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2005.12.005 | |||
44322957 | 208669 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -3 | 3 | ChEMBL | 753 | 19 | 10 | 7 | 0.6 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CC(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL86573 | 208669 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -3 | 3 | ChEMBL | 753 | 19 | 10 | 7 | 0.6 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CC(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL5075506 | 216867 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -676 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
CHEMBL5091236 | 217789 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -48 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
44442972 | 153107 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 538 | 8 | 1 | 6 | 4.2 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4cncnc4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL397562 | 153107 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 538 | 8 | 1 | 6 | 4.2 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4cncnc4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
145948912 | 167583 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -8 | 4 | ChEMBL | 1170 | 17 | 14 | 11 | 0.7 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.5b01285 | |||
CHEMBL4299454 | 167583 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -8 | 4 | ChEMBL | 1170 | 17 | 14 | 11 | 0.7 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.5b01285 | |||
46885622 | 8461 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 492 | 4 | 1 | 3 | 4.7 | CC(C)N1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccc(F)cc3F)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1 | 10.1021/jm9017866 | |||
CHEMBL1093801 | 8461 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 492 | 4 | 1 | 3 | 4.7 | CC(C)N1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccc(F)cc3F)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1 | 10.1021/jm9017866 | |||
CHEMBL2323785 | 211970 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | -35 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||||
CHEMBL500516 | 216605 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | 1 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(N)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
44405913 | 132804 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 859 | 21 | 8 | 7 | 3.1 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc2ccc3ccccc3c2)C(=O)N[C@@H](C)C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL369915 | 132804 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 859 | 21 | 8 | 7 | 3.1 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc2ccc3ccccc3c2)C(=O)N[C@@H](C)C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
44349134 | 117387 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 679 | 12 | 2 | 6 | 4.4 | CCC(CC)N(Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL339708 | 117387 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 679 | 12 | 2 | 6 | 4.4 | CCC(CC)N(Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/s0960-894x(03)00796-0 | |||
90643833 | 111819 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 920 | 15 | 7 | 6 | 1.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287340 | 111819 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 920 | 15 | 7 | 6 | 1.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
46232225 | 203539 | None | 0 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | -6 | 3 | ChEMBL | 849 | 12 | 8 | 8 | 0.6 | N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
CHEMBL602852 | 203539 | None | 0 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | -6 | 3 | ChEMBL | 849 | 12 | 8 | 8 | 0.6 | N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
90643828 | 111815 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 806 | 12 | 6 | 6 | 1.5 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287335 | 111815 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 806 | 12 | 6 | 6 | 1.5 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
90643834 | 111820 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 806 | 12 | 6 | 6 | 1.5 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287341 | 111820 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 806 | 12 | 6 | 6 | 1.5 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
118735102 | 118866 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -6 | 4 | ChEMBL | 707 | 15 | 8 | 6 | 1.1 | CC(=O)N[C@H]1Cc2ccccc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O | 10.1021/ml500436s | |||
CHEMBL3421679 | 118866 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -6 | 4 | ChEMBL | 707 | 15 | 8 | 6 | 1.1 | CC(=O)N[C@H]1Cc2ccccc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O | 10.1021/ml500436s | |||
10348630 | 30204 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CCC(C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL139042 | 30204 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CCC(C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
45487295 | 199830 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -13 | 3 | ChEMBL | 617 | 18 | 8 | 7 | 0.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccccc1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL569221 | 199830 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -13 | 3 | ChEMBL | 617 | 18 | 8 | 7 | 0.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccccc1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
137660671 | 159311 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -812 | 4 | ChEMBL | 1708 | 20 | 19 | 21 | -2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4098785 | 159311 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -812 | 4 | ChEMBL | 1708 | 20 | 19 | 21 | -2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
137656489 | 159804 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 3 | ChEMBL | 1125 | 13 | 13 | 12 | -1.2 | C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4104402 | 159804 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 3 | ChEMBL | 1125 | 13 | 13 | 12 | -1.2 | C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL195468 | 211561 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | -7 | 3 | ChEMBL | None | None | None | CCCCCCCCCCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||||
44394583 | 122411 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 6 | 3 | ChEMBL | 771 | 18 | 8 | 6 | 2.4 | CC(C)(C)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL359927 | 122411 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 6 | 3 | ChEMBL | 771 | 18 | 8 | 6 | 2.4 | CC(C)(C)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44442956 | 94401 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 526 | 8 | 2 | 5 | 4.1 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ncc[nH]4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL250701 | 94401 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 526 | 8 | 2 | 5 | 4.1 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4ncc[nH]4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
44397658 | 125493 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 622 | 10 | 2 | 7 | 6.1 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(Cl)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL364582 | 125493 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 622 | 10 | 2 | 7 | 6.1 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(Cl)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
155567399 | 176070 | None | 0 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -501 | 3 | ChEMBL | 769 | 19 | 9 | 7 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4588429 | 176070 | None | 0 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -501 | 3 | ChEMBL | 769 | 19 | 9 | 7 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL3287073 | 213768 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL432895 | 216096 | None | 2 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -1 | 4 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010061n | |||||
45487288 | 199812 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -18 | 3 | ChEMBL | 623 | 16 | 8 | 6 | 0.4 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(F)cc1F)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL569076 | 199812 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -18 | 3 | ChEMBL | 623 | 16 | 8 | 6 | 0.4 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(F)cc1F)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
45487286 | 199797 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -41 | 3 | ChEMBL | 631 | 16 | 8 | 8 | -0.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc2c(c1)OCO2)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL568940 | 199797 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -41 | 3 | ChEMBL | 631 | 16 | 8 | 8 | -0.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc2c(c1)OCO2)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
44358660 | 168662 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL435697 | 168662 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL544851 | 168662 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
44305790 | 102895 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | 1 | 3 | ChEMBL | 407 | 10 | 5 | 3 | 2.4 | NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1 | 10.1016/s0960-894x(03)00318-4 | |||
CHEMBL305559 | 102895 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | 1 | 3 | ChEMBL | 407 | 10 | 5 | 3 | 2.4 | NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1 | 10.1016/s0960-894x(03)00318-4 | |||
44305704 | 205795 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | 1 | 3 | ChEMBL | 407 | 10 | 5 | 3 | 2.4 | NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1 | 10.1016/s0960-894x(03)00318-4 | |||
CHEMBL64954 | 205795 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | 1 | 3 | ChEMBL | 407 | 10 | 5 | 3 | 2.4 | NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1 | 10.1016/s0960-894x(03)00318-4 | |||
44396986 | 67453 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 20 | 3 | ChEMBL | 568 | 7 | 3 | 4 | 4.3 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@H]3CC[C@@H]2NC3)CC1 | 10.1016/j.bmcl.2005.05.109 | |||
CHEMBL188966 | 67453 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 20 | 3 | ChEMBL | 568 | 7 | 3 | 4 | 4.3 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@H]3CC[C@@H]2NC3)CC1 | 10.1016/j.bmcl.2005.05.109 | |||
44278194 | 99424 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 8 | 2 | ChEMBL | 848 | 22 | 9 | 7 | 1.9 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(CC)cccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL282533 | 99424 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 8 | 2 | ChEMBL | 848 | 22 | 9 | 7 | 1.9 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(CC)cccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
24873537 | 146149 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 6 | 1 | 5 | 4.8 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1 | 10.1016/j.bmcl.2007.09.079 | |||
CHEMBL391902 | 146149 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 6 | 1 | 5 | 4.8 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1 | 10.1016/j.bmcl.2007.09.079 | |||
CHEMBL2370964 | 212426 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.1c01295 | |||||
90643830 | 111817 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 787 | 10 | 4 | 6 | 2.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287337 | 111817 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 787 | 10 | 4 | 6 | 2.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
44349019 | 114501 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 583 | 8 | 2 | 7 | 3.1 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cnnc2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL333283 | 114501 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 583 | 8 | 2 | 7 | 3.1 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cnnc2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/s0960-894x(03)00796-0 | |||
44322986 | 106153 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -3 | 3 | ChEMBL | 713 | 19 | 9 | 7 | 0.1 | CC(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL313377 | 106153 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -3 | 3 | ChEMBL | 713 | 19 | 9 | 7 | 0.1 | CC(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL2370964 | 212426 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O | 10.1021/jm030119t | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.7b00353 | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.7b00353 | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.7b00353 | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.7b00353 | |||||
CHEMBL5087814 | 217609 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -4 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
10098133 | 15021 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 518 | 7 | 1 | 4 | 4.9 | CC(C)NCC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1 | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209191 | 15021 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 518 | 7 | 1 | 4 | 4.9 | CC(C)NCC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1 | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL2323790 | 211975 | None | 0 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | -7 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||||
24882615 | 97545 | None | 0 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | -5 | 3 | ChEMBL | 371 | 6 | 2 | 3 | 3.1 | NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O | 10.1021/jm701303z | |||
CHEMBL270270 | 97545 | None | 0 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | -5 | 3 | ChEMBL | 371 | 6 | 2 | 3 | 3.1 | NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O | 10.1021/jm701303z | |||
11157584 | 168347 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 587 | 10 | 2 | 5 | 4.3 | CCN(CC)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL433710 | 168347 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 587 | 10 | 2 | 5 | 4.3 | CCN(CC)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
44358660 | 168662 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL435697 | 168662 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL544851 | 168662 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
122184577 | 122495 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -19 | 4 | ChEMBL | 1102 | 17 | 12 | 11 | 0.8 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||
CHEMBL3600838 | 122495 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -19 | 4 | ChEMBL | 1102 | 17 | 12 | 11 | 0.8 | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||
CHEMBL105113 | 210925 | None | 0 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -1 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010524p | |||||
44349111 | 117550 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 679 | 10 | 2 | 6 | 4.2 | CC(C)(C)CN(Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL339979 | 117550 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 679 | 10 | 2 | 6 | 4.2 | CC(C)(C)CN(Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/s0960-894x(03)00796-0 | |||
44397651 | 66972 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 670 | 10 | 2 | 7 | 7.2 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(Cl)cc3Cl)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL186675 | 66972 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 670 | 10 | 2 | 7 | 7.2 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(Cl)cc3Cl)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
46885560 | 7813 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 492 | 4 | 1 | 5 | 4.0 | C[C@H]1CN(C(=O)[C@H]2CN(c3ncccn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL1089485 | 7813 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 492 | 4 | 1 | 5 | 4.0 | C[C@H]1CN(C(=O)[C@H]2CN(c3ncccn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
44448628 | 155207 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 571 | 7 | 1 | 4 | 6.3 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(OC)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL402009 | 155207 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 571 | 7 | 1 | 4 | 6.3 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(OC)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL430489 | 216081 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -2 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010524p | |||||
137631599 | 156617 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -16 | 4 | ChEMBL | 1694 | 20 | 20 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4067967 | 156617 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -16 | 4 | ChEMBL | 1694 | 20 | 20 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
90643848 | 111833 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 714 | 12 | 6 | 6 | 1.5 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287355 | 111833 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 714 | 12 | 6 | 6 | 1.5 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
137660671 | 159311 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -812 | 4 | ChEMBL | 1708 | 20 | 19 | 21 | -2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4098785 | 159311 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -812 | 4 | ChEMBL | 1708 | 20 | 19 | 21 | -2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
137658158 | 159811 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -10 | 4 | ChEMBL | 1714 | 21 | 22 | 21 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4104465 | 159811 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -10 | 4 | ChEMBL | 1714 | 21 | 22 | 21 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
16132144 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(03)00318-4 | |||||
16133793 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(03)00318-4 | |||||
44273719 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(03)00318-4 | |||||
CHEMBL214332 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(03)00318-4 | |||||
44413880 | 77975 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -10 | 3 | ChEMBL | 639 | 14 | 6 | 7 | 0.7 | NC(N)=NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1 | 10.1021/jm060384p | |||
CHEMBL209587 | 77975 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -10 | 3 | ChEMBL | 639 | 14 | 6 | 7 | 0.7 | NC(N)=NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1 | 10.1021/jm060384p | |||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(02)00830-2 | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(02)00830-2 | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(02)00830-2 | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(02)00830-2 | |||||
10257242 | 15036 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 39 | 4 | ChEMBL | 560 | 7 | 0 | 4 | 5.1 | CC(=O)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209252 | 15036 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 39 | 4 | ChEMBL | 560 | 7 | 0 | 4 | 5.1 | CC(=O)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C | 10.1016/j.bmcl.2010.06.038 | |||
10077258 | 15037 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 15 | 4 | ChEMBL | 596 | 8 | 0 | 5 | 4.5 | CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)S(C)(=O)=O | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209253 | 15037 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 15 | 4 | ChEMBL | 596 | 8 | 0 | 5 | 4.5 | CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)S(C)(=O)=O | 10.1016/j.bmcl.2010.06.038 | |||
25132867 | 172601 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 15 | 3 | ChEMBL | 623 | 11 | 2 | 5 | 3.9 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1ccccn1 | 10.1021/jm800525p | |||
CHEMBL448337 | 172601 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 15 | 3 | ChEMBL | 623 | 11 | 2 | 5 | 3.9 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1ccccn1 | 10.1021/jm800525p | |||
CHEMBL2371888 | 212605 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | None | None | None | CCCCC(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@]2(CCc3c(C)cccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||||
71452716 | 78924 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 2 | 2 | ChEMBL | 781 | 22 | 9 | 8 | -0.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL2112920 | 78924 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 2 | 2 | ChEMBL | 781 | 22 | 9 | 8 | -0.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL322610 | 213693 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | -2 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010524p | |||||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(02)00459-6 | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(02)00459-6 | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(02)00459-6 | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/s0960-894x(02)00459-6 | |||||
71452716 | 78924 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 2 | 2 | ChEMBL | 781 | 22 | 9 | 8 | -0.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
CHEMBL2112920 | 78924 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 2 | 2 | ChEMBL | 781 | 22 | 9 | 8 | -0.0 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)01052-1 | |||
CHEMBL508501 | 217431 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 36 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/jm801300c | |||||
CHEMBL438596 | 216242 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm050780s | |||||
CHEMBL438596 | 216242 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm050780s | |||||
90643848 | 111833 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 714 | 12 | 6 | 6 | 1.5 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287355 | 111833 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 714 | 12 | 6 | 6 | 1.5 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
44358630 | 28322 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 588 | 10 | 2 | 7 | 5.5 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL137452 | 28322 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 588 | 10 | 2 | 7 | 5.5 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL541866 | 28322 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 588 | 10 | 2 | 7 | 5.5 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL443590 | 216386 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O | 10.1021/jm030119t | |||||
CHEMBL311175 | 213557 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -2 | 2 | ChEMBL | None | None | None | CCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)00459-6 | |||||
11845630 | 139601 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 4 | 3 | ChEMBL | 678 | 15 | 5 | 6 | 3.6 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL379490 | 139601 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 4 | 3 | ChEMBL | 678 | 15 | 5 | 6 | 3.6 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
44394009 | 124417 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 571 | 9 | 3 | 5 | 3.7 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNC2CC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL363684 | 124417 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 571 | 9 | 3 | 5 | 3.7 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNC2CC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
44413881 | 137680 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 4 | 3 | ChEMBL | 707 | 15 | 6 | 7 | 1.9 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL375559 | 137680 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 4 | 3 | ChEMBL | 707 | 15 | 6 | 7 | 1.9 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N | 10.1021/jm060384p | |||
46885324 | 8212 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 432 | 3 | 2 | 3 | 3.4 | C[C@H]1CN(C(=O)[C@@H]2CNC[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1 | 10.1021/jm9017866 | |||
CHEMBL1092210 | 8212 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 432 | 3 | 2 | 3 | 3.4 | C[C@H]1CN(C(=O)[C@@H]2CNC[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1 | 10.1021/jm9017866 | |||
45487287 | 200105 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -3 | 3 | ChEMBL | 633 | 17 | 8 | 8 | -0.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccc2c1OCO2)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL570903 | 200105 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -3 | 3 | ChEMBL | 633 | 17 | 8 | 8 | -0.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccc2c1OCO2)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
46886010 | 7876 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 492 | 4 | 1 | 3 | 4.7 | CC(C)N1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccc(F)c(F)c3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1 | 10.1021/jm9017866 | |||
CHEMBL1089892 | 7876 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 492 | 4 | 1 | 3 | 4.7 | CC(C)N1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccc(F)c(F)c3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1 | 10.1021/jm9017866 | |||
137649543 | 157412 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 1025 | 18 | 12 | 15 | -1.5 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4077331 | 157412 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 1025 | 18 | 12 | 15 | -1.5 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
155549760 | 173981 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | -66 | 3 | ChEMBL | 711 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4539621 | 173981 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | -66 | 3 | ChEMBL | 711 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1021/jm050780s | |||
CHEMBL2310901 | 211957 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -4 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O | 10.1021/jm049579s | |||||
CHEMBL5087859 | 217613 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -4 | 3 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
44322959 | 156166 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -13 | 3 | ChEMBL | 727 | 21 | 9 | 7 | 0.6 | CCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL406276 | 156166 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -13 | 3 | ChEMBL | 727 | 21 | 9 | 7 | 0.6 | CCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
11423083 | 96892 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | -26 | 3 | ChEMBL | 882 | 32 | 9 | 7 | 4.9 | CCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL265236 | 96892 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | -26 | 3 | ChEMBL | 882 | 32 | 9 | 7 | 4.9 | CCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm0490843 | |||
CHEMBL3287327 | 213769 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -5 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
155539948 | 172989 | None | 0 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | -131 | 3 | ChEMBL | 705 | 20 | 11 | 7 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4515666 | 172989 | None | 0 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | -131 | 3 | ChEMBL | 705 | 20 | 11 | 7 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL138771 | 211213 | None | 0 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | 1 | 3 | ChEMBL | None | None | None | CC(=O)N(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)Cc1ccccc1 | 10.1016/j.bmcl.2003.08.078 | |||||
44358705 | 96678 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CCC(C)NC(=O)[C@H]3CCNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL263461 | 96678 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 602 | 10 | 2 | 7 | 5.9 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CCC(C)NC(=O)[C@H]3CCNC[C@@H]3c3ccccc3)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
1334 | 1501 | None | 4 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -6 | 4 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
16133814 | 1501 | None | 4 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -6 | 4 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
CHEMBL437050 | 1501 | None | 4 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -6 | 4 | ChEMBL | None | None | None | None | 10.1021/jm000211e | |||||
49789765 | 67253 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 363 | 4 | 1 | 5 | 4.7 | COc1cccc(-c2cnc3c(NC(C)=O)cc(-c4ccsc4)cn23)c1 | nan | |||
CHEMBL1879413 | 67253 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 363 | 4 | 1 | 5 | 4.7 | COc1cccc(-c2cnc3c(NC(C)=O)cc(-c4ccsc4)cn23)c1 | nan | |||
CHEMBL3600841 | 214278 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||||
11845276 | 80084 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 2 | 3 | ChEMBL | 605 | 14 | 4 | 4 | 4.9 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)CCc1ccccc1 | 10.1021/jm060384p | |||
CHEMBL212976 | 80084 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 2 | 3 | ChEMBL | 605 | 14 | 4 | 4 | 4.9 | N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)CCc1ccccc1 | 10.1021/jm060384p | |||
1334 | 1501 | None | 4 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -6 | 4 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
16133814 | 1501 | None | 4 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -6 | 4 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
CHEMBL437050 | 1501 | None | 4 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -6 | 4 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
90643838 | 111823 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 831 | 10 | 3 | 5 | 4.1 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287345 | 111823 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 831 | 10 | 3 | 5 | 4.1 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
44456304 | 155344 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 609 | 10 | 1 | 5 | 4.7 | CCC(=O)N1C[C@@H](C(=O)N2CCN(c3ccc(C)cc3[C@@H](NC(=O)CCN(C)C)C(C)C)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2007.10.115 | |||
CHEMBL402787 | 155344 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 609 | 10 | 1 | 5 | 4.7 | CCC(=O)N1C[C@@H](C(=O)N2CCN(c3ccc(C)cc3[C@@H](NC(=O)CCN(C)C)C(C)C)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2007.10.115 | |||
56676633 | 63702 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 641 | 6 | 1 | 3 | 7.6 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NCC(C)C | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801121 | 63702 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 641 | 6 | 1 | 3 | 7.6 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NCC(C)C | 10.1016/j.bmcl.2010.06.062 | |||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm050780s | |||||
44394736 | 123383 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 25 | 3 | ChEMBL | 797 | 19 | 9 | 7 | 2.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccsc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL361579 | 123383 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 25 | 3 | ChEMBL | 797 | 19 | 9 | 7 | 2.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccsc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44390424 | 63948 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 645 | 10 | 1 | 6 | 4.8 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2ccc3ncccc3c2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL180635 | 63948 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 645 | 10 | 1 | 6 | 4.8 | CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2ccc3ncccc3c2)CC1 | 10.1016/j.bmcl.2005.01.060 | |||
137660993 | 159541 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -63 | 4 | ChEMBL | 1680 | 20 | 21 | 21 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4101216 | 159541 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -63 | 4 | ChEMBL | 1680 | 20 | 21 | 21 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
44433448 | 88518 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 500 | 6 | 1 | 4 | 4.9 | CC(C)[C@H](N)c1cccc(F)c1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.079 | |||
CHEMBL234983 | 88518 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 500 | 6 | 1 | 4 | 4.9 | CC(C)[C@H](N)c1cccc(F)c1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.079 | |||
44433448 | 88518 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 500 | 6 | 1 | 4 | 4.9 | CC(C)[C@H](N)c1cccc(F)c1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL234983 | 88518 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 500 | 6 | 1 | 4 | 4.9 | CC(C)[C@H](N)c1cccc(F)c1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.06.088 | |||
145966716 | 164400 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -70 | 4 | ChEMBL | 887 | 11 | 12 | 9 | -0.3 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL4212209 | 164400 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -70 | 4 | ChEMBL | 887 | 11 | 12 | 9 | -0.3 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL2070254 | 211644 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||||
155567887 | 176152 | None | 0 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | 1 | 3 | ChEMBL | 676 | 19 | 10 | 7 | -1.1 | CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.9b00198 | |||
CHEMBL4590532 | 176152 | None | 0 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | 1 | 3 | ChEMBL | 676 | 19 | 10 | 7 | -1.1 | CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.9b00198 | |||
164623811 | 186006 | None | 0 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | -1 | 3 | ChEMBL | 614 | 11 | 4 | 4 | 6.2 | CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N | 10.1021/acs.jmedchem.0c02041 | |||
CHEMBL4868636 | 186006 | None | 0 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | -1 | 3 | ChEMBL | 614 | 11 | 4 | 4 | 6.2 | CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N | 10.1021/acs.jmedchem.0c02041 | |||
CHEMBL438596 | 216242 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm050780s | |||||
44391940 | 12254 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 21 | 2 | ChEMBL | 614 | 8 | 4 | 6 | 2.1 | C[C@H](N)C(=O)N1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL1184624 | 12254 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 21 | 2 | ChEMBL | 614 | 8 | 4 | 6 | 2.1 | C[C@H](N)C(=O)N1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL2145456 | 12254 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 21 | 2 | ChEMBL | 614 | 8 | 4 | 6 | 2.1 | C[C@H](N)C(=O)N1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2004.10.020 | |||
44405366 | 71985 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 643 | 12 | 3 | 5 | 4.7 | NC(CC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(CNC(=O)Cc3ccccc3)CCCCC2)CC1)c1ccccc1 | 10.1016/j.bmcl.2005.08.061 | |||
CHEMBL197327 | 71985 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 643 | 12 | 3 | 5 | 4.7 | NC(CC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(CNC(=O)Cc3ccccc3)CCCCC2)CC1)c1ccccc1 | 10.1016/j.bmcl.2005.08.061 | |||
11375764 | 66710 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -38 | 2 | ChEMBL | 515 | 6 | 3 | 3 | 5.2 | C[C@@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1 | 10.1021/jm0400496 | |||
CHEMBL185469 | 66710 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -38 | 2 | ChEMBL | 515 | 6 | 3 | 3 | 5.2 | C[C@@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1 | 10.1021/jm0400496 | |||
CHEMBL414778 | 215616 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -478 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON | 10.1021/jm049579s | |||||
90643850 | 111834 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 711 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287357 | 111834 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 711 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
44359589 | 31487 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -3 | 3 | ChEMBL | 685 | 20 | 4 | 7 | 1.4 | CC(=O)N(CCc1c[nH]cn1)CC(=O)N(CC(=O)N(CCCCN)CC(=O)N(CCc1c[nH]c2ccccc12)CC(N)=O)Cc1ccccc1 | 10.1016/j.bmcl.2003.08.078 | |||
CHEMBL140324 | 31487 | None | 0 | Mouse | Functional | pEC50 | = | 4.6 | 4.6 | -3 | 3 | ChEMBL | 685 | 20 | 4 | 7 | 1.4 | CC(=O)N(CCc1c[nH]cn1)CC(=O)N(CC(=O)N(CCCCN)CC(=O)N(CCc1c[nH]c2ccccc12)CC(N)=O)Cc1ccccc1 | 10.1016/j.bmcl.2003.08.078 | |||
51350911 | 58821 | None | 0 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -5 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
53322399 | 58821 | None | 0 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -5 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
91932357 | 58821 | None | 0 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -5 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
CHEMBL1688109 | 58821 | None | 0 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | -5 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
11156852 | 65706 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 531 | 7 | 3 | 5 | 2.9 | NCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL183434 | 65706 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 531 | 7 | 3 | 5 | 2.9 | NCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
44394078 | 161811 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 611 | 10 | 3 | 6 | 4.3 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCc2ccco2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL413556 | 161811 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 611 | 10 | 3 | 6 | 4.3 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCc2ccco2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
90643834 | 111820 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 806 | 12 | 6 | 6 | 1.5 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287341 | 111820 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 806 | 12 | 6 | 6 | 1.5 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
56669816 | 63698 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 625 | 5 | 1 | 3 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@H]2C(C)(C)C(=O)NC1CC1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801117 | 63698 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 625 | 5 | 1 | 3 | 7.1 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@H]2C(C)(C)C(=O)NC1CC1 | 10.1016/j.bmcl.2010.06.062 | |||
25133907 | 176829 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 5 | 3 | ChEMBL | 518 | 9 | 2 | 4 | 3.0 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1 | 10.1021/jm800525p | |||
CHEMBL460138 | 176829 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 5 | 3 | ChEMBL | 518 | 9 | 2 | 4 | 3.0 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1 | 10.1021/jm800525p | |||
162672255 | 182977 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 1100 | 18 | 14 | 11 | 0.6 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL4791788 | 182977 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 1100 | 18 | 14 | 11 | 0.6 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
90643823 | 111784 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 696 | 18 | 9 | 7 | 0.3 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(Cc1cccc2ccccc12)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287074 | 111784 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 696 | 18 | 9 | 7 | 0.3 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(Cc1cccc2ccccc12)C(N)=O | 10.1021/jm500064t | |||
44323033 | 107208 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -4 | 3 | ChEMBL | 747 | 19 | 10 | 7 | 0.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL316259 | 107208 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -4 | 3 | ChEMBL | 747 | 19 | 10 | 7 | 0.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
162672255 | 182977 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 1100 | 18 | 14 | 11 | 0.6 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL4791788 | 182977 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 1100 | 18 | 14 | 11 | 0.6 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL5077144 | 216973 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -13 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
44441645 | 94180 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 63 | 3 | ChEMBL | 605 | 12 | 2 | 7 | 4.4 | CCCCCCC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL249277 | 94180 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 63 | 3 | ChEMBL | 605 | 12 | 2 | 7 | 4.4 | CCCCCCC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
137637656 | 156329 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 40 | 3 | ChEMBL | 1045 | 20 | 14 | 15 | -2.2 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4064777 | 156329 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 40 | 3 | ChEMBL | 1045 | 20 | 14 | 15 | -2.2 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
145988867 | 167199 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -3 | 3 | ChEMBL | 660 | 17 | 7 | 6 | 1.7 | CCCC[C@H](NC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2018.04.021 | |||
CHEMBL4289983 | 167199 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -3 | 3 | ChEMBL | 660 | 17 | 7 | 6 | 1.7 | CCCC[C@H](NC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2018.04.021 | |||
133053557 | 163801 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -15 | 3 | ChEMBL | 851 | 11 | 12 | 9 | -1.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL4204975 | 163801 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -15 | 3 | ChEMBL | 851 | 11 | 12 | 9 | -1.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
90643824 | 111811 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 842 | 11 | 3 | 7 | 3.4 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287330 | 111811 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 842 | 11 | 3 | 7 | 3.4 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
90643828 | 111815 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 806 | 12 | 6 | 6 | 1.5 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287335 | 111815 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 806 | 12 | 6 | 6 | 1.5 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
44405378 | 140652 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 655 | 10 | 3 | 5 | 4.1 | NC1(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCN(C3(CNC(=O)Cc4ccccc4)CCCCC3)CC2)Cc2ccccc2C1 | 10.1016/j.bmcl.2005.08.061 | |||
CHEMBL381197 | 140652 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 655 | 10 | 3 | 5 | 4.1 | NC1(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCN(C3(CNC(=O)Cc4ccccc4)CCCCC3)CC2)Cc2ccccc2C1 | 10.1016/j.bmcl.2005.08.061 | |||
44305956 | 102816 | None | 0 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | 1 | 3 | ChEMBL | 490 | 11 | 5 | 4 | 2.9 | NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NC1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(03)00318-4 | |||
CHEMBL305132 | 102816 | None | 0 | Mouse | Functional | pEC50 | = | 5.6 | 5.6 | 1 | 3 | ChEMBL | 490 | 11 | 5 | 4 | 2.9 | NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NC1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(03)00318-4 | |||
44441636 | 94065 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 6 | 2 | ChEMBL | 520 | 9 | 2 | 4 | 4.8 | CCCCC1(CC#N)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL248701 | 94065 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 6 | 2 | ChEMBL | 520 | 9 | 2 | 4 | 4.8 | CCCCC1(CC#N)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
11512024 | 202941 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -5 | 2 | ChEMBL | 525 | 7 | 1 | 4 | 4.6 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(F)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL598616 | 202941 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -5 | 2 | ChEMBL | 525 | 7 | 1 | 4 | 4.6 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(F)cc1 | 10.1016/j.bmc.2010.01.049 | |||
46885326 | 8213 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 450 | 3 | 2 | 3 | 3.5 | C[C@H]1CN(C(=O)[C@@H]2CNC[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)c(F)c1 | 10.1021/jm9017866 | |||
CHEMBL1092211 | 8213 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 450 | 3 | 2 | 3 | 3.5 | C[C@H]1CN(C(=O)[C@@H]2CNC[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)c(F)c1 | 10.1021/jm9017866 | |||
46228813 | 203906 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -16 | 2 | ChEMBL | 538 | 8 | 1 | 6 | 3.9 | COc1ccc(N(C(=O)CN2C=CN(c3cccnc3)C(=O)C(Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL604911 | 203906 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -16 | 2 | ChEMBL | 538 | 8 | 1 | 6 | 3.9 | COc1ccc(N(C(=O)CN2C=CN(c3cccnc3)C(=O)C(Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
49862378 | 15048 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 45 | 4 | ChEMBL | 534 | 8 | 0 | 4 | 4.6 | CC(=O)N(CC(CC(C)C)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C | 10.1016/j.bmcl.2010.06.038 | |||
CHEMBL1209321 | 15048 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 45 | 4 | ChEMBL | 534 | 8 | 0 | 4 | 4.6 | CC(=O)N(CC(CC(C)C)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C | 10.1016/j.bmcl.2010.06.038 | |||
11170774 | 158456 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 1180 | 19 | 13 | 12 | -0.4 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(N)=O)C(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4089689 | 158456 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 1180 | 19 | 13 | 12 | -0.4 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(N)=O)C(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/acs.jmedchem.6b01707 | |||
137656180 | 159120 | None | 0 | Mouse | Functional | pEC50 | = | 7.5 | 7.5 | -13 | 3 | ChEMBL | 1005 | 12 | 12 | 11 | -2.0 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL4096678 | 159120 | None | 0 | Mouse | Functional | pEC50 | = | 7.5 | 7.5 | -13 | 3 | ChEMBL | 1005 | 12 | 12 | 11 | -2.0 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O | 10.1021/acs.jmedchem.6b01707 | |||
CHEMBL2096759 | 211667 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -7 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON | 10.1021/jm049579s | |||||
44391927 | 13996 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 57 | 3 | ChEMBL | 557 | 7 | 3 | 5 | 2.9 | CN1CCNC[C@H]1C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C2CCCCC2)CC1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL1196971 | 13996 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 57 | 3 | ChEMBL | 557 | 7 | 3 | 5 | 2.9 | CN1CCNC[C@H]1C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C2CCCCC2)CC1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL3216393 | 13996 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 57 | 3 | ChEMBL | 557 | 7 | 3 | 5 | 2.9 | CN1CCNC[C@H]1C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C2CCCCC2)CC1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL187125 | 211514 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 30 | 3 | ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)Nc1ccco1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||||
CHEMBL89270 | 218389 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 1 | 3 | ChEMBL | None | None | None | NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1 | 10.1016/s0960-894x(03)00552-3 | |||||
73353216 | 89510 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | 5 | 2 | ChEMBL | 806 | 20 | 9 | 7 | 0.9 | CCCC(=O)N[C@@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2ccccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL2372046 | 89510 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | 5 | 2 | ChEMBL | 806 | 20 | 9 | 7 | 0.9 | CCCC(=O)N[C@@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2ccccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
11181804 | 128574 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 641 | 11 | 3 | 6 | 4.8 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm049278i | |||
CHEMBL366706 | 128574 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 641 | 11 | 3 | 6 | 4.8 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm049278i | |||
CHEMBL2323789 | 211974 | None | 0 | Mouse | Functional | pEC50 | = | 6.5 | 6.5 | -147 | 3 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm301253y | |||||
73353216 | 89510 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | 5 | 2 | ChEMBL | 806 | 20 | 9 | 7 | 0.9 | CCCC(=O)N[C@@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2ccccc2C1 | 10.1016/j.bmcl.2005.08.012 | |||
CHEMBL2372046 | 89510 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | 5 | 2 | ChEMBL | 806 | 20 | 9 | 7 | 0.9 | CCCC(=O)N[C@@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2ccccc2C1 | 10.1016/j.bmcl.2005.08.012 | |||
11237444 | 127532 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -5 | 2 | ChEMBL | 503 | 8 | 4 | 3 | 5.4 | CC(C)(N)C/N=C(\Nc1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1 | 10.1021/jm0400496 | |||
CHEMBL366042 | 127532 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -5 | 2 | ChEMBL | 503 | 8 | 4 | 3 | 5.4 | CC(C)(N)C/N=C(\Nc1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1 | 10.1021/jm0400496 | |||
11845813 | 139891 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 3 | ChEMBL | 473 | 10 | 3 | 4 | 3.0 | NC(N)=NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@H](N)Cc1ccccc1 | 10.1021/jm060384p | |||
CHEMBL379879 | 139891 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 3 | ChEMBL | 473 | 10 | 3 | 4 | 3.0 | NC(N)=NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@H](N)Cc1ccccc1 | 10.1021/jm060384p | |||
11847312 | 79793 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | 1 | 3 | ChEMBL | 613 | 12 | 6 | 6 | 1.8 | N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1 | 10.1021/jm060384p | |||
CHEMBL211798 | 79793 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | 1 | 3 | ChEMBL | 613 | 12 | 6 | 6 | 1.8 | N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1 | 10.1021/jm060384p | |||
CHEMBL3287338 | 213771 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||||
73353216 | 89510 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 5 | 2 | ChEMBL | 806 | 20 | 9 | 7 | 0.9 | CCCC(=O)N[C@@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2ccccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL2372046 | 89510 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 5 | 2 | ChEMBL | 806 | 20 | 9 | 7 | 0.9 | CCCC(=O)N[C@@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2ccccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
90643802 | 111805 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287322 | 111805 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL275303 | 213280 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | 4 | 4 | ChEMBL | None | None | None | CC(=O)N1Cc2ccccc2C[C@@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
25128749 | 178575 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 37 | 3 | ChEMBL | 560 | 10 | 2 | 4 | 3.2 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O | 10.1021/jm800525p | |||
CHEMBL466380 | 178575 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 37 | 3 | ChEMBL | 560 | 10 | 2 | 4 | 3.2 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O | 10.1021/jm800525p | |||
73348634 | 89505 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 2 | ChEMBL | 975 | 13 | 10 | 9 | 0.8 | CCCCC(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2Cc3ccccc3CN2C1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL2371902 | 89505 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 2 | ChEMBL | 975 | 13 | 10 | 9 | 0.8 | CCCCC(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2Cc3ccccc3CN2C1=O | 10.1016/s0960-894x(03)00114-8 | |||
90643806 | 111809 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287326 | 111809 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
44405681 | 71817 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 896 | 21 | 9 | 7 | 2.9 | C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(NC(=O)Cc2ccccc2)CC[C@@H](c2ccccc2)CC1)C(N)=O | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL196773 | 71817 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 896 | 21 | 9 | 7 | 2.9 | C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(NC(=O)Cc2ccccc2)CC[C@@H](c2ccccc2)CC1)C(N)=O | 10.1016/j.bmcl.2005.08.083 | |||
44405826 | 141358 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 848 | 21 | 9 | 7 | 2.5 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL383143 | 141358 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 848 | 21 | 9 | 7 | 2.5 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
44405857 | 159039 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 944 | 21 | 10 | 7 | 4.9 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(NC(=O)Cc2ccccc2)CC[C@@H](c2ccccc2)CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1C(N)=O | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL409589 | 159039 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 944 | 21 | 10 | 7 | 4.9 | N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(NC(=O)Cc2ccccc2)CC[C@@H](c2ccccc2)CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1C(N)=O | 10.1016/j.bmcl.2005.08.083 | |||
44401522 | 12788 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 97 | 2 | ChEMBL | 585 | 8 | 4 | 5 | 3.5 | CC(C)[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1 | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL1188041 | 12788 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 97 | 2 | ChEMBL | 585 | 8 | 4 | 5 | 3.5 | CC(C)[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1 | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL534928 | 12788 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 97 | 2 | ChEMBL | 585 | 8 | 4 | 5 | 3.5 | CC(C)[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1 | 10.1016/j.bmcl.2005.02.068 | |||
44404522 | 72315 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 862 | 22 | 9 | 7 | 2.8 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
CHEMBL198309 | 72315 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 862 | 22 | 9 | 7 | 2.8 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
168284256 | 191055 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -64 | 4 | ChEMBL | 2383 | 48 | 33 | 31 | -4.2 | CCCC[C@@H]1NC(=O)[C@@H]2CSC/C(=N/OCC(=O)NCCOCCOCCOCCN=[N+]=[N-])CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5185775 | 191055 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -64 | 4 | ChEMBL | 2383 | 48 | 33 | 31 | -4.2 | CCCC[C@@H]1NC(=O)[C@@H]2CSC/C(=N/OCC(=O)NCCOCCOCCOCCN=[N+]=[N-])CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
16132144 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm010061n | |||||
16133793 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm010061n | |||||
44273719 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm010061n | |||||
CHEMBL214332 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm010061n | |||||
137659790 | 159416 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -1 | 4 | ChEMBL | 1728 | 21 | 21 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||
CHEMBL4099889 | 159416 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -1 | 4 | ChEMBL | 1728 | 21 | 21 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||
1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -33 | 7 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.7b00353 | |||||
49862749 | 15157 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 641 | 5 | 0 | 5 | 6.6 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)N1CCCC1 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209800 | 15157 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 641 | 5 | 0 | 5 | 6.6 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)N1CCCC1 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL3287327 | 213769 | None | 0 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -1 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL5094215 | 217971 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -15 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
137637026 | 156015 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 28 | 3 | ChEMBL | 1052 | 20 | 15 | 14 | -1.4 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4060937 | 156015 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 28 | 3 | ChEMBL | 1052 | 20 | 15 | 14 | -1.4 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
11215553 | 8396 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 60 | 2 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.02.058 | |||
CHEMBL1093305 | 8396 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 60 | 2 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.02.058 | |||
145964017 | 164136 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 4 | ChEMBL | 915 | 11 | 12 | 9 | 0.5 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
CHEMBL4208874 | 164136 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 4 | ChEMBL | 915 | 11 | 12 | 9 | 0.5 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.8b00488 | |||
90643803 | 111806 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -3 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287323 | 111806 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -3 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL438596 | 216242 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm050780s | |||||
44441641 | 94354 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 69 | 3 | ChEMBL | 603 | 8 | 2 | 7 | 4.0 | Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL250508 | 94354 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 69 | 3 | ChEMBL | 603 | 8 | 2 | 7 | 4.0 | Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
16172929 | 215461 | None | 14 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0501432 | |||||
CHEMBL412536 | 215461 | None | 14 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0501432 | |||||
11215553 | 8396 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 60 | 2 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1093305 | 8396 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 60 | 2 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
49862747 | 15154 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 615 | 6 | 1 | 5 | 6.1 | CCNC(C)(C)[C@H]1OC2(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209798 | 15154 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 615 | 6 | 1 | 5 | 6.1 | CCNC(C)(C)[C@H]1OC2(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL2371712 | 212568 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON | 10.1021/jm049579s | |||||
CHEMBL413260 | 215519 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 5 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm960845e | |||||
CHEMBL5075712 | 216882 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -102 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
90643805 | 111808 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287325 | 111808 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
90643808 | 111810 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -14 | 4 | ChEMBL | 747 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287328 | 111810 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -14 | 4 | ChEMBL | 747 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm201489a | |||||
16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm201489a | |||||
44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm201489a | |||||
CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -12 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm201489a | |||||
CHEMBL501394 | 216625 | None | 0 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | 2 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
46919520 | 15144 | None | 0 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -3 | 6 | ChEMBL | 597 | 4 | 0 | 5 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209788 | 15144 | None | 0 | Mouse | Functional | pEC50 | = | 8.5 | 8.5 | -3 | 6 | ChEMBL | 597 | 4 | 0 | 5 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL5090285 | 217743 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -1 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
90643805 | 111808 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287325 | 111808 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
168272660 | 190542 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -28 | 4 | ChEMBL | 2202 | 33 | 32 | 24 | -2.1 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3c(F)c(F)c(c(F)c3F)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5178164 | 190542 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -28 | 4 | ChEMBL | 2202 | 33 | 32 | 24 | -2.1 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3c(F)c(F)c(c(F)c3F)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | |||
127047475 | 139836 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | 1630 | 54 | 21 | 19 | -1.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.5b01894 | |||
132991507 | 139836 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | 1630 | 54 | 21 | 19 | -1.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.5b01894 | |||
CHEMBL3798421 | 139836 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | 1630 | 54 | 21 | 19 | -1.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.5b01894 | |||
CHEMBL3287338 | 213771 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||||
CHEMBL3349030 | 213864 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 3 | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O | 10.1021/jm000211e | |||||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2003.09.036 | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2003.09.036 | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/j.bmcl.2003.09.036 | |||
44413914 | 139605 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -12 | 3 | ChEMBL | 652 | 15 | 5 | 6 | 2.6 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL379508 | 139605 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -12 | 3 | ChEMBL | 652 | 15 | 5 | 6 | 2.6 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
16132144 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acsmedchemlett.9b00198 | |||||
16133793 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acsmedchemlett.9b00198 | |||||
44273719 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acsmedchemlett.9b00198 | |||||
CHEMBL214332 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acsmedchemlett.9b00198 | |||||
44456222 | 97978 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 637 | 10 | 1 | 6 | 5.0 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1 | 10.1016/j.bmcl.2007.10.115 | |||
CHEMBL272538 | 97978 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 637 | 10 | 1 | 6 | 5.0 | Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1 | 10.1016/j.bmcl.2007.10.115 | |||
11296600 | 123009 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 628 | 9 | 4 | 6 | 3.8 | CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm049278i | |||
CHEMBL360716 | 123009 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 628 | 9 | 4 | 6 | 3.8 | CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm049278i | |||
56679956 | 63721 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 675 | 4 | 0 | 3 | 7.7 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CCC(F)(F)C1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801214 | 63721 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 675 | 4 | 0 | 3 | 7.7 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CCC(F)(F)C1 | 10.1016/j.bmcl.2010.06.062 | |||
49862746 | 15153 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 601 | 5 | 1 | 5 | 5.7 | CNC(C)(C)[C@H]1OC2(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209797 | 15153 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 601 | 5 | 1 | 5 | 5.7 | CNC(C)(C)[C@H]1OC2(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.068 | |||
90643802 | 111805 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287322 | 111805 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
11296600 | 123009 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 628 | 9 | 4 | 6 | 3.8 | CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL360716 | 123009 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 628 | 9 | 4 | 6 | 3.8 | CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL5091245 | 217790 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -5 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
44441644 | 154928 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 66 | 3 | ChEMBL | 577 | 9 | 2 | 7 | 3.5 | CCC(C)C1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL400456 | 154928 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 66 | 3 | ChEMBL | 577 | 9 | 2 | 7 | 3.5 | CCC(C)C1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2006.11.084 | |||
CHEMBL322610 | 213693 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -2 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
46885711 | 8072 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 123 | 3 | ChEMBL | 504 | 3 | 1 | 3 | 5.4 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(Cl)cc1 | 10.1021/jm9017866 | |||
CHEMBL1091150 | 8072 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 123 | 3 | ChEMBL | 504 | 3 | 1 | 3 | 5.4 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(Cl)cc1 | 10.1021/jm9017866 | |||
155543031 | 173284 | None | 0 | Mouse | Functional | pEC50 | = | 7.5 | 7.5 | -50 | 3 | ChEMBL | 803 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4522298 | 173284 | None | 0 | Mouse | Functional | pEC50 | = | 7.5 | 7.5 | -50 | 3 | ChEMBL | 803 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
44394692 | 66235 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 17 | 3 | ChEMBL | 792 | 19 | 9 | 7 | 2.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccncc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL184466 | 66235 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 17 | 3 | ChEMBL | 792 | 19 | 9 | 7 | 2.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccncc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
71459938 | 79012 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 4 | 4 | ChEMBL | 622 | 9 | 2 | 6 | 6.6 | COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)C2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL2113043 | 79012 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 4 | 4 | ChEMBL | 622 | 9 | 2 | 6 | 6.6 | COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)C2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
44393823 | 124041 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 676 | 9 | 2 | 6 | 4.8 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CN2CCN(c3ccccc3)CC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL362880 | 124041 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 676 | 9 | 2 | 6 | 4.8 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CN2CCN(c3ccccc3)CC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
44405450 | 72543 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 581 | 11 | 2 | 5 | 3.1 | CN(C)CC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(CNC(=O)Cc3ccccc3)CCCCC2)CC1 | 10.1016/j.bmcl.2005.08.061 | |||
CHEMBL199061 | 72543 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 581 | 11 | 2 | 5 | 3.1 | CN(C)CC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(CNC(=O)Cc3ccccc3)CCCCC2)CC1 | 10.1016/j.bmcl.2005.08.061 | |||
CHEMBL427205 | 215813 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -21 | 3 | ChEMBL | None | None | None | CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC1=O | 10.1021/jm0510326 | |||||
155565321 | 175680 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -100 | 3 | ChEMBL | 718 | 13 | 5 | 6 | 0.7 | CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4579448 | 175680 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -100 | 3 | ChEMBL | 718 | 13 | 5 | 6 | 0.7 | CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C | 10.1021/acs.jmedchem.9b00053 | |||
168274920 | 190372 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -102 | 4 | ChEMBL | 1319 | 15 | 14 | 15 | 0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5175444 | 190372 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -102 | 4 | ChEMBL | 1319 | 15 | 14 | 15 | 0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL321870 | 213691 | None | 0 | Mouse | Functional | pEC50 | = | 6.5 | 6.5 | -5 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010524p | |||||
51350799 | 58818 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -7 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
53323763 | 58818 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -7 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
91932356 | 58818 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -7 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
CHEMBL1688105 | 58818 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -7 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
44358698 | 30932 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 574 | 8 | 2 | 7 | 5.0 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CCC(=O)N[C@@H]3CCc4ccccc4NC3=O)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
CHEMBL139803 | 30932 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 574 | 8 | 2 | 7 | 5.0 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CCC(=O)N[C@@H]3CCc4ccccc4NC3=O)c2=O)cc1 | 10.1016/j.bmcl.2003.09.026 | |||
56676634 | 63705 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 667 | 5 | 1 | 3 | 7.5 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@H]2C(C)(C)C(=O)NCC(F)(F)F | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801124 | 63705 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 667 | 5 | 1 | 3 | 7.5 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@H]2C(C)(C)C(=O)NCC(F)(F)F | 10.1016/j.bmcl.2010.06.062 | |||
168272615 | 190496 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -60 | 4 | ChEMBL | 1319 | 15 | 14 | 15 | 0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5177494 | 190496 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -60 | 4 | ChEMBL | 1319 | 15 | 14 | 15 | 0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.2c00793 | |||
137655905 | 158920 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -74 | 4 | ChEMBL | 1666 | 20 | 22 | 21 | -3.9 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4094606 | 158920 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -74 | 4 | ChEMBL | 1666 | 20 | 22 | 21 | -3.9 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
44444507 | 94226 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 635 | 9 | 2 | 5 | 5.7 | CC(C)C[C@H](NC(=O)[C@@H](C)N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL249571 | 94226 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 635 | 9 | 2 | 5 | 5.7 | CC(C)C[C@H](NC(=O)[C@@H](C)N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.06.088 | |||
25132524 | 176863 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 7 | 3 | ChEMBL | 504 | 8 | 2 | 4 | 2.7 | CC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1 | 10.1021/jm800525p | |||
CHEMBL460349 | 176863 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 7 | 3 | ChEMBL | 504 | 8 | 2 | 4 | 2.7 | CC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1 | 10.1021/jm800525p | |||
44394690 | 124715 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 14 | 3 | ChEMBL | 792 | 19 | 9 | 7 | 2.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccccn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL364119 | 124715 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 14 | 3 | ChEMBL | 792 | 19 | 9 | 7 | 2.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccccn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44394658 | 168440 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 5 | 3 | ChEMBL | 758 | 18 | 10 | 7 | 0.0 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)C(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL434329 | 168440 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 5 | 3 | ChEMBL | 758 | 18 | 10 | 7 | 0.0 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)C(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
162672691 | 183307 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 4 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL4795842 | 183307 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 4 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL5076315 | 216916 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -3 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
90643837 | 111822 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 750 | 11 | 3 | 7 | 3.4 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287344 | 111822 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 750 | 11 | 3 | 7 | 3.4 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
155562237 | 175813 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -1548 | 3 | ChEMBL | 692 | 15 | 8 | 7 | 0.0 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4582276 | 175813 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -1548 | 3 | ChEMBL | 692 | 15 | 8 | 7 | 0.0 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
9852256 | 175471 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -7 | 3 | ChEMBL | 632 | 15 | 8 | 7 | 0.3 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.9b00198 | |||
CHEMBL4574756 | 175471 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -7 | 3 | ChEMBL | 632 | 15 | 8 | 7 | 0.3 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.9b00198 | |||
45487300 | 199815 | None | 0 | Mouse | Functional | pEC50 | = | 4.5 | 4.5 | -10 | 3 | ChEMBL | 605 | 15 | 8 | 8 | -0.6 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1ccc2c(c1)OCO2)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL569086 | 199815 | None | 0 | Mouse | Functional | pEC50 | = | 4.5 | 4.5 | -10 | 3 | ChEMBL | 605 | 15 | 8 | 8 | -0.6 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1ccc2c(c1)OCO2)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
44413537 | 139634 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -2 | 2 | ChEMBL | 739 | 10 | 10 | 7 | 0.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)CCCCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
CHEMBL379627 | 139634 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -2 | 2 | ChEMBL | 739 | 10 | 10 | 7 | 0.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)CCCCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmcl.2006.04.050 | |||
172468874 | 197097 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -6 | 2 | ChEMBL | 863 | 11 | 12 | 10 | 0.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2cc(N)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
CHEMBL5438629 | 197097 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -6 | 2 | ChEMBL | 863 | 11 | 12 | 10 | 0.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2cc(N)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/acs.jmedchem.2c01587 | |||
46228845 | 201844 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -39 | 2 | ChEMBL | 551 | 9 | 1 | 5 | 4.5 | COc1ccc(N(C(=O)CN2C=CN(Cc3ccccc3)C(=O)C(Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL591026 | 201844 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -39 | 2 | ChEMBL | 551 | 9 | 1 | 5 | 4.5 | COc1ccc(N(C(=O)CN2C=CN(Cc3ccccc3)C(=O)C(Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
46228848 | 201855 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 551 | 8 | 0 | 6 | 4.5 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)C(Cc3nn(C)c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL591061 | 201855 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 551 | 8 | 0 | 6 | 4.5 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)C(Cc3nn(C)c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
46228849 | 201867 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 595 | 10 | 0 | 7 | 4.8 | CCn1nc(CC2(OC)C(=O)N(CC(=O)N(c3ccc(OC)cc3)C(C)C)C=CN(c3ccccc3)C2=O)c2ccccc21 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL591123 | 201867 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 595 | 10 | 0 | 7 | 4.8 | CCn1nc(CC2(OC)C(=O)N(CC(=O)N(c3ccc(OC)cc3)C(C)C)C=CN(c3ccccc3)C2=O)c2ccccc21 | 10.1016/j.bmc.2010.01.049 | |||
46228847 | 201869 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 620 | 11 | 1 | 7 | 6.0 | O=C(CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)CP(=O)(Oc1ccccc1)Oc1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL591132 | 201869 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 620 | 11 | 1 | 7 | 6.0 | O=C(CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)CP(=O)(Oc1ccccc1)Oc1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
46228842 | 201872 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -38 | 2 | ChEMBL | 592 | 8 | 1 | 6 | 4.3 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(N2CCOCC2)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL591194 | 201872 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -38 | 2 | ChEMBL | 592 | 8 | 1 | 6 | 4.3 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(N2CCOCC2)cc1 | 10.1016/j.bmc.2010.01.049 | |||
46228844 | 201873 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -26 | 2 | ChEMBL | 587 | 10 | 1 | 7 | 4.3 | COc1ccc(N(C(=O)CN2C=CN(Cc3cccs3)C(=O)C(Cc3n[nH]c4ccccc34)(OC)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL591195 | 201873 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -26 | 2 | ChEMBL | 587 | 10 | 1 | 7 | 4.3 | COc1ccc(N(C(=O)CN2C=CN(Cc3cccs3)C(=O)C(Cc3n[nH]c4ccccc34)(OC)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
46228888 | 201943 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -8 | 2 | ChEMBL | 481 | 6 | 1 | 4 | 3.2 | CC(C)N(C(=O)CN1C=CN(C)C(=O)C(Cc2n[nH]c3cc(F)ccc23)C1=O)c1ccc(F)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL591717 | 201943 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -8 | 2 | ChEMBL | 481 | 6 | 1 | 4 | 3.2 | CC(C)N(C(=O)CN1C=CN(C)C(=O)C(Cc2n[nH]c3cc(F)ccc23)C1=O)c1ccc(F)cc1 | 10.1016/j.bmc.2010.01.049 | |||
46228763 | 202642 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 525 | 7 | 1 | 4 | 4.6 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)[C@@H](Cc2n[nH]c3cc(F)ccc23)C1=O)c1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL596602 | 202642 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 525 | 7 | 1 | 4 | 4.6 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)[C@@H](Cc2n[nH]c3cc(F)ccc23)C1=O)c1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
46228659 | 202849 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -20 | 2 | ChEMBL | 537 | 8 | 1 | 5 | 4.5 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)[C@@H](Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL598010 | 202849 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -20 | 2 | ChEMBL | 537 | 8 | 1 | 5 | 4.5 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)[C@@H](Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
46228850 | 202883 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 544 | 9 | 2 | 6 | 3.9 | O=C(CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)CP(=O)(O)Oc1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL598208 | 202883 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 544 | 9 | 2 | 6 | 3.9 | O=C(CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)CP(=O)(O)Oc1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
46228725 | 202913 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 507 | 7 | 1 | 4 | 4.5 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)[C@@H](Cc2n[nH]c3ccccc23)C1=O)c1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL598442 | 202913 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 507 | 7 | 1 | 4 | 4.5 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)[C@@H](Cc2n[nH]c3ccccc23)C1=O)c1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
46228841 | 202981 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 503 | 8 | 0 | 4 | 4.8 | COc1ccc(N(C(=O)CN2C=CN(C3CCCCC3)C(=O)C(Cc3ccccc3)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL598831 | 202981 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 503 | 8 | 0 | 4 | 4.8 | COc1ccc(N(C(=O)CN2C=CN(C3CCCCC3)C(=O)C(Cc3ccccc3)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
46228843 | 204102 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 543 | 8 | 1 | 5 | 4.6 | COc1ccc(N(C(=O)CN2C=CN(C3CCCCC3)C(=O)C(Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL605970 | 204102 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 2 | ChEMBL | 543 | 8 | 1 | 5 | 4.6 | COc1ccc(N(C(=O)CN2C=CN(C3CCCCC3)C(=O)C(Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
11706338 | 204164 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -33 | 2 | ChEMBL | 523 | 7 | 2 | 5 | 4.2 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(O)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL1237150 | 204164 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -33 | 2 | ChEMBL | 523 | 7 | 2 | 5 | 4.2 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(O)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL1237166 | 204164 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -33 | 2 | ChEMBL | 523 | 7 | 2 | 5 | 4.2 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(O)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL606399 | 204164 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -33 | 2 | ChEMBL | 523 | 7 | 2 | 5 | 4.2 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccc(O)cc1 | 10.1016/j.bmc.2010.01.049 | |||
11846673 | 80025 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 3 | ChEMBL | 515 | 11 | 3 | 4 | 3.1 | CC(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL212766 | 80025 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 3 | ChEMBL | 515 | 11 | 3 | 4 | 3.1 | CC(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
137643385 | 158223 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 1069 | 21 | 13 | 16 | -1.8 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
CHEMBL4087072 | 158223 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 1069 | 21 | 13 | 16 | -1.8 | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.7b00353 | |||
90643836 | 111821 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 803 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287343 | 111821 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 803 | 17 | 10 | 7 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
56666397 | 63695 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 613 | 5 | 1 | 3 | 7.0 | CCNC(=O)C(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801098 | 63695 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 613 | 5 | 1 | 3 | 7.0 | CCNC(=O)C(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
162672691 | 183307 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 4 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL4795842 | 183307 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 4 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
46885415 | 8281 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 10 | 3 | ChEMBL | 468 | 4 | 1 | 3 | 4.5 | C[C@H]1CN(C(=O)[C@H]2CN(C3CCC3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL1092571 | 8281 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 10 | 3 | ChEMBL | 468 | 4 | 1 | 3 | 4.5 | C[C@H]1CN(C(=O)[C@H]2CN(C3CCC3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL432201 | 216094 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 6 | 4 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm500064t | |||||
44444432 | 94457 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 491 | 6 | 0 | 5 | 4.4 | CC(C)N1C[C@@H](C(=O)N2CCN(c3ccccc3Cn3ccnc3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL250976 | 94457 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 491 | 6 | 0 | 5 | 4.4 | CC(C)N1C[C@@H](C(=O)N2CCN(c3ccccc3Cn3ccnc3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2007.06.088 | |||
44397356 | 66938 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.4 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CN(C)CC[C@@H]3c3ccc(F)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL186557 | 66938 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.4 | COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CN(C)CC[C@@H]3c3ccc(F)cc3)c2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
44431512 | 146012 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -87 | 4 | ChEMBL | 1038 | 14 | 12 | 10 | 0.9 | CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)N2Cc3ccccc3CC(NC1=O)C2=O | 10.1016/j.bmcl.2007.02.020 | |||
CHEMBL391796 | 146012 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -87 | 4 | ChEMBL | 1038 | 14 | 12 | 10 | 0.9 | CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)N2Cc3ccccc3CC(NC1=O)C2=O | 10.1016/j.bmcl.2007.02.020 | |||
CHEMBL3287352 | 213773 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||||
51351024 | 58819 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -13 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
53318435 | 58819 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -13 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
91932358 | 58819 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -13 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
CHEMBL1688106 | 58819 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -13 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
11685018 | 203149 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -204 | 2 | ChEMBL | 519 | 5 | 1 | 4 | 4.4 | O=C1C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)C=CN1CC(=O)N1CCCCc2ccccc21 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL599867 | 203149 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -204 | 2 | ChEMBL | 519 | 5 | 1 | 4 | 4.4 | O=C1C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)C=CN1CC(=O)N1CCCCc2ccccc21 | 10.1016/j.bmc.2010.01.049 | |||
11627577 | 203648 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -4 | 2 | ChEMBL | 507 | 7 | 1 | 4 | 4.5 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL603468 | 203648 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -4 | 2 | ChEMBL | 507 | 7 | 1 | 4 | 4.5 | CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccccc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL438596 | 216242 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm050780s | |||||
CHEMBL80803 | 218375 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -9 | 2 | ChEMBL | None | None | None | CCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O | 10.1016/s0960-894x(02)00459-6 | |||||
10123761 | 99547 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 15 | 2 | ChEMBL | 898 | 21 | 9 | 7 | 2.1 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(Br)cccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL283214 | 99547 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 15 | 2 | ChEMBL | 898 | 21 | 9 | 7 | 2.1 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(Br)cccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
44275121 | 96539 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 1022 | 13 | 11 | 9 | 1.5 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3cc(Cl)ccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL262437 | 96539 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 1022 | 13 | 11 | 9 | 1.5 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3cc(Cl)ccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
11851038 | 140422 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 497 | 6 | 0 | 5 | 5.2 | CN(C)[C@H]1C[C@@H](C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1021/jm050780s | |||
CHEMBL380691 | 140422 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 497 | 6 | 0 | 5 | 5.2 | CN(C)[C@H]1C[C@@H](C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1021/jm050780s | |||
11636019 | 72384 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 655 | 10 | 3 | 5 | 4.3 | O=C(Cc1ccccc1)NCC1(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)CCCCC1 | 10.1016/j.bmcl.2005.08.061 | |||
CHEMBL198535 | 72384 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 655 | 10 | 3 | 5 | 4.3 | O=C(Cc1ccccc1)NCC1(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)CCCCC1 | 10.1016/j.bmcl.2005.08.061 | |||
49862739 | 15147 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 23 | 2 | ChEMBL | 583 | 6 | 0 | 4 | 7.3 | CCC(CC)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209791 | 15147 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 23 | 2 | ChEMBL | 583 | 6 | 0 | 4 | 7.3 | CCC(CC)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1 | 10.1016/j.bmcl.2010.06.068 | |||
44401585 | 13768 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | 19 | 2 | ChEMBL | 585 | 8 | 3 | 5 | 3.6 | CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL1195347 | 13768 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | 19 | 2 | ChEMBL | 585 | 8 | 3 | 5 | 3.6 | CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL554368 | 13768 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | 19 | 2 | ChEMBL | 585 | 8 | 3 | 5 | 3.6 | CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C | 10.1016/j.bmcl.2005.02.068 | |||
46232227 | 201626 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -6 | 3 | ChEMBL | 863 | 12 | 9 | 8 | 0.7 | N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
CHEMBL589517 | 201626 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -6 | 3 | ChEMBL | 863 | 12 | 9 | 8 | 0.7 | N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
137660993 | 159541 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -63 | 4 | ChEMBL | 1680 | 20 | 21 | 21 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4101216 | 159541 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -63 | 4 | ChEMBL | 1680 | 20 | 21 | 21 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
46228660 | 202850 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -21 | 2 | ChEMBL | 537 | 8 | 1 | 5 | 4.5 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)[C@H](Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL598011 | 202850 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -21 | 2 | ChEMBL | 537 | 8 | 1 | 5 | 4.5 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)[C@H](Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
90643808 | 111810 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -14 | 4 | ChEMBL | 747 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287328 | 111810 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -14 | 4 | ChEMBL | 747 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
11341811 | 120188 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 546 | 7 | 3 | 5 | 3.5 | C[C@H](O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
CHEMBL351161 | 120188 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 546 | 7 | 3 | 5 | 3.5 | C[C@H](O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1021/jm0304109 | |||
44393863 | 127620 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 642 | 9 | 4 | 6 | 4.4 | CC(NC1CCC(N)CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL366321 | 127620 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 642 | 9 | 4 | 6 | 4.4 | CC(NC1CCC(N)CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL439691 | 216309 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -5 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON | 10.1021/jm049579s | |||||
44391938 | 11750 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 20 | 2 | ChEMBL | 599 | 9 | 3 | 5 | 3.9 | CC(C)CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL1181567 | 11750 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 20 | 2 | ChEMBL | 599 | 9 | 3 | 5 | 3.9 | CC(C)CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2004.10.020 | |||
CHEMBL2145455 | 11750 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 20 | 2 | ChEMBL | 599 | 9 | 3 | 5 | 3.9 | CC(C)CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1 | 10.1016/j.bmcl.2004.10.020 | |||
44397220 | 167400 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 28 | 3 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | CN1C[C@@H]2CC[C@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2 | 10.1016/j.bmcl.2005.05.109 | |||
CHEMBL429387 | 167400 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 28 | 3 | ChEMBL | 582 | 7 | 2 | 4 | 4.7 | CN1C[C@@H]2CC[C@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2 | 10.1016/j.bmcl.2005.05.109 | |||
CHEMBL438030 | 216205 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -21 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O | 10.1021/jm030119t | |||||
CHEMBL204864 | 211625 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -12 | 4 | ChEMBL | None | None | None | CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCC)NC1=O | 10.1021/jm0510326 | |||||
44455893 | 155728 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 651 | 10 | 1 | 5 | 5.5 | CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(C(F)(F)F)c(F)c2)CC1 | 10.1016/j.bmcl.2007.10.115 | |||
CHEMBL404706 | 155728 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 651 | 10 | 1 | 5 | 5.5 | CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(C(F)(F)F)c(F)c2)CC1 | 10.1016/j.bmcl.2007.10.115 | |||
CHEMBL409636 | 215233 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm030119t | |||||
44349228 | 18822 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 538 | 9 | 0 | 4 | 4.4 | CCN(C(C)=O)C(C)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)N2CCC2)Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2003.10.056 | |||
CHEMBL127861 | 18822 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 538 | 9 | 0 | 4 | 4.4 | CCN(C(C)=O)C(C)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)N2CCC2)Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2003.10.056 | |||
44305770 | 205252 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | 1 | 3 | ChEMBL | 448 | 9 | 5 | 4 | 2.2 | NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCc2ccccc2C1 | 10.1016/s0960-894x(03)00318-4 | |||
CHEMBL62228 | 205252 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | 1 | 3 | ChEMBL | 448 | 9 | 5 | 4 | 2.2 | NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCc2ccccc2C1 | 10.1016/s0960-894x(03)00318-4 | |||
CHEMBL431242 | 216085 | None | 0 | Mouse | Functional | pEC50 | = | 4.5 | 4.5 | -1 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010524p | |||||
46885713 | 7801 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 495 | 3 | 1 | 4 | 4.7 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(C#N)cc1 | 10.1021/jm9017866 | |||
CHEMBL1089442 | 7801 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 495 | 3 | 1 | 4 | 4.7 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(C#N)cc1 | 10.1021/jm9017866 | |||
44278195 | 98860 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 35 | 2 | ChEMBL | 834 | 21 | 9 | 7 | 1.6 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(C)cccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL27848 | 98860 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 35 | 2 | ChEMBL | 834 | 21 | 9 | 7 | 1.6 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(C)cccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
10123761 | 99547 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 15 | 2 | ChEMBL | 898 | 21 | 9 | 7 | 2.1 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(Br)cccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
CHEMBL283214 | 99547 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 15 | 2 | ChEMBL | 898 | 21 | 9 | 7 | 2.1 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(Br)cccc2C1 | 10.1016/s0960-894x(02)00830-2 | |||
44275119 | 169123 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 37 | 2 | ChEMBL | 1033 | 15 | 11 | 10 | 1.2 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3c(cccc3OCC)C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL439361 | 169123 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 37 | 2 | ChEMBL | 1033 | 15 | 11 | 10 | 1.2 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3c(cccc3OCC)C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
10123761 | 99547 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 15 | 2 | ChEMBL | 898 | 21 | 9 | 7 | 2.1 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(Br)cccc2C1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL283214 | 99547 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 15 | 2 | ChEMBL | 898 | 21 | 9 | 7 | 2.1 | CCCCC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CCc2c(Br)cccc2C1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL185869 | 211512 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 6 | 3 | ChEMBL | None | None | None | CCOC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||||
CHEMBL3600843 | 214280 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -4 | 4 | ChEMBL | None | None | None | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.5b00102 | |||||
51350673 | 58817 | None | 0 | Mouse | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
53317148 | 58817 | None | 0 | Mouse | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
91932362 | 58817 | None | 0 | Mouse | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
CHEMBL1688104 | 58817 | None | 0 | Mouse | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 3 | ChEMBL | 1635 | 23 | 20 | 21 | -1.8 | C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm101425m | |||
25022598 | 95083 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 613 | 6 | 2 | 5 | 5.1 | Cc1ccc(N2CCN(C(=O)[C@H]3[C@@H](c4ccc(Cl)cc4)CCN3C(=O)[C@H]3Cc4ccccc4CN3)CC2)c([C@@H](N)C(C)C)c1 | 10.1016/j.bmcl.2008.01.125 | |||
CHEMBL255007 | 95083 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 613 | 6 | 2 | 5 | 5.1 | Cc1ccc(N2CCN(C(=O)[C@H]3[C@@H](c4ccc(Cl)cc4)CCN3C(=O)[C@H]3Cc4ccccc4CN3)CC2)c([C@@H](N)C(C)C)c1 | 10.1016/j.bmcl.2008.01.125 | |||
CHEMBL500743 | 216612 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -22 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C1=O | 10.1021/jm801300c | |||||
44456958 | 97457 | None | 0 | Mouse | Functional | pEC50 | = | 4.5 | 4.5 | -10 | 3 | ChEMBL | 308 | 4 | 1 | 2 | 2.8 | CCCN1C(=O)C(Cc2ccccc2)NC(=O)c2ccccc21 | 10.1021/jm701303z | |||
CHEMBL269837 | 97457 | None | 0 | Mouse | Functional | pEC50 | = | 4.5 | 4.5 | -10 | 3 | ChEMBL | 308 | 4 | 1 | 2 | 2.8 | CCCN1C(=O)C(Cc2ccccc2)NC(=O)c2ccccc21 | 10.1021/jm701303z | |||
49862744 | 15151 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 629 | 5 | 1 | 5 | 5.6 | CC(=O)NC(C)(C)[C@@H]1OC2(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209795 | 15151 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 629 | 5 | 1 | 5 | 5.6 | CC(=O)NC(C)(C)[C@@H]1OC2(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.068 | |||
11613741 | 201738 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -223 | 2 | ChEMBL | 555 | 8 | 1 | 5 | 4.7 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)C(Cc3n[nH]c4cc(F)ccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
CHEMBL590281 | 201738 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -223 | 2 | ChEMBL | 555 | 8 | 1 | 5 | 4.7 | COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)C(Cc3n[nH]c4cc(F)ccc34)C2=O)C(C)C)cc1 | 10.1016/j.bmc.2010.01.049 | |||
16172929 | 215461 | None | 14 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
CHEMBL412536 | 215461 | None | 14 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm500064t | |||||
11181804 | 128574 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 641 | 11 | 3 | 6 | 4.8 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL366706 | 128574 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 641 | 11 | 3 | 6 | 4.8 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
145988152 | 167140 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -1 | 3 | ChEMBL | 720 | 17 | 7 | 6 | 2.3 | CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Br)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2018.04.021 | |||
CHEMBL4288909 | 167140 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -1 | 3 | ChEMBL | 720 | 17 | 7 | 6 | 2.3 | CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Br)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2018.04.021 | |||
44413828 | 139380 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 1 | 3 | ChEMBL | 632 | 12 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1 | 10.1021/jm060384p | |||
CHEMBL379168 | 139380 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 1 | 3 | ChEMBL | 632 | 12 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1 | 10.1021/jm060384p | |||
90661465 | 77191 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 46 | 2 | ChEMBL | 693 | 9 | 5 | 6 | 4.0 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C3CC3)CN2)CC1.CC(F)(F)C(=O)O | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL2028958 | 77191 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 46 | 2 | ChEMBL | 693 | 9 | 5 | 6 | 4.0 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C3CC3)CN2)CC1.CC(F)(F)C(=O)O | 10.1016/j.bmcl.2005.02.068 | |||
CHEMBL2078649 | 77191 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 46 | 2 | ChEMBL | 693 | 9 | 5 | 6 | 4.0 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C3CC3)CN2)CC1.CC(F)(F)C(=O)O | 10.1016/j.bmcl.2005.02.068 | |||
44393809 | 66199 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 589 | 11 | 4 | 6 | 2.9 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCCO)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL184325 | 66199 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 589 | 11 | 4 | 6 | 2.9 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCCO)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL438920 | 216270 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -12 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON | 10.1021/jm049579s | |||||
168295644 | 192421 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 1 | 4 | ChEMBL | 1106 | 17 | 13 | 12 | 1.5 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccccc2CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.1c01848 | |||
CHEMBL5206336 | 192421 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 1 | 4 | ChEMBL | 1106 | 17 | 13 | 12 | 1.5 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccccc2CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.1c01848 | |||
11375529 | 120215 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 502 | 6 | 2 | 4 | 3.4 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
CHEMBL351400 | 120215 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 502 | 6 | 2 | 4 | 3.4 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
CHEMBL427629 | 215818 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -2 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O | 10.1021/jm030119t | |||||
44405365 | 71970 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 641 | 10 | 3 | 5 | 4.6 | O=C(Cc1ccccc1)NCC1(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4N3)CC2)CCCCC1 | 10.1016/j.bmcl.2005.08.061 | |||
CHEMBL197278 | 71970 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 641 | 10 | 3 | 5 | 4.6 | O=C(Cc1ccccc1)NCC1(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4N3)CC2)CCCCC1 | 10.1016/j.bmcl.2005.08.061 | |||
46203213 | 7960 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 471 | 3 | 1 | 4 | 4.2 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cccnc1 | 10.1021/jm9017866 | |||
CHEMBL1090486 | 7960 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 471 | 3 | 1 | 4 | 4.2 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cccnc1 | 10.1021/jm9017866 | |||
CHEMBL1204058 | 7960 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 471 | 3 | 1 | 4 | 4.2 | C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cccnc1 | 10.1021/jm9017866 | |||
137659790 | 159416 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -1 | 4 | ChEMBL | 1728 | 21 | 21 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL4099889 | 159416 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -1 | 4 | ChEMBL | 1728 | 21 | 21 | 21 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.8b00170 | |||
CHEMBL5077811 | 217004 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -87 | 4 | ChEMBL | None | None | None | CC(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/acs.jmedchem.1c00095 | |||||
46885863 | 8474 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 41 | 2 | ChEMBL | 446 | 3 | 1 | 3 | 3.8 | C[C@H]1CN(C(=O)[C@@H]2CN(C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1 | 10.1021/jm9017866 | |||
CHEMBL1093858 | 8474 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 41 | 2 | ChEMBL | 446 | 3 | 1 | 3 | 3.8 | C[C@H]1CN(C(=O)[C@@H]2CN(C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1 | 10.1021/jm9017866 | |||
25128751 | 173688 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 23 | 3 | ChEMBL | 629 | 11 | 2 | 6 | 4.0 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cscn1 | 10.1021/jm800525p | |||
CHEMBL453300 | 173688 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 23 | 3 | ChEMBL | 629 | 11 | 2 | 6 | 4.0 | CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cscn1 | 10.1021/jm800525p | |||
25128748 | 190100 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 8 | 3 | ChEMBL | 490 | 7 | 2 | 4 | 2.3 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C)C1=O | 10.1021/jm800525p | |||
CHEMBL517108 | 190100 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 8 | 3 | ChEMBL | 490 | 7 | 2 | 4 | 2.3 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C)C1=O | 10.1021/jm800525p | |||
44577510 | 188843 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -4 | 4 | ChEMBL | 893 | 12 | 11 | 11 | 0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm701181n | |||
CHEMBL504986 | 188843 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -4 | 4 | ChEMBL | 893 | 12 | 11 | 11 | 0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm701181n | |||
44275191 | 81920 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 1066 | 13 | 11 | 9 | 1.6 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3cc(Br)ccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL216474 | 81920 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 1066 | 13 | 11 | 9 | 1.6 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3cc(Br)ccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
11330869 | 120044 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 599 | 8 | 2 | 5 | 4.4 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CN2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
CHEMBL349886 | 120044 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 599 | 8 | 2 | 5 | 4.4 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CN2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
44349470 | 16940 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 589 | 11 | 1 | 5 | 4.9 | CCN(C(C)=O)C(C)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)NCc2ccccn2)Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2003.10.056 | |||
CHEMBL125308 | 16940 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 589 | 11 | 1 | 5 | 4.9 | CCN(C(C)=O)C(C)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)NCc2ccccn2)Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2003.10.056 | |||
44405426 | 135862 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 669 | 11 | 3 | 5 | 4.7 | O=C(Cc1ccccc1)NCC1(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)CC3Cc4ccccc4CN3)CC2)CCCCC1 | 10.1016/j.bmcl.2005.08.061 | |||
CHEMBL373037 | 135862 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 669 | 11 | 3 | 5 | 4.7 | O=C(Cc1ccccc1)NCC1(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)CC3Cc4ccccc4CN3)CC2)CCCCC1 | 10.1016/j.bmcl.2005.08.061 | |||
46884748 | 8398 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 16 | 2 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@H]1CC2(CCN(C(=O)[C@H]3CN(C(C)(C)C)C[C@@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.02.058 | |||
CHEMBL1093307 | 8398 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 16 | 2 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@H]1CC2(CCN(C(=O)[C@H]3CN(C(C)(C)C)C[C@@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.02.058 | |||
CHEMBL3350327 | 213929 | None | 0 | Mouse | Functional | pEC50 | = | 5.4 | 5.4 | 2 | 3 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O | 10.1021/jm0492756 | |||||
45487410 | 199894 | None | 0 | Mouse | Functional | pEC50 | = | 5.4 | 5.4 | -12 | 3 | ChEMBL | 655 | 16 | 8 | 6 | 1.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(C(F)(F)F)c1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL569696 | 199894 | None | 0 | Mouse | Functional | pEC50 | = | 5.4 | 5.4 | -12 | 3 | ChEMBL | 655 | 16 | 8 | 6 | 1.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(C(F)(F)F)c1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
44448477 | 95610 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 577 | 6 | 1 | 3 | 6.6 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2cc(F)c(F)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL257615 | 95610 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 577 | 6 | 1 | 3 | 6.6 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2cc(F)c(F)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
162643435 | 181773 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -4 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL4776340 | 181773 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -4 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
162643435 | 181773 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -4 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
CHEMBL4776340 | 181773 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -4 | 2 | ChEMBL | 1150 | 18 | 14 | 11 | 1.8 | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O | 10.1021/acs.jmedchem.0c01620 | |||
46885416 | 8282 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 472 | 6 | 1 | 4 | 3.6 | COCCN1C[C@H](c2ccc(F)cc2F)[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)C1 | 10.1021/jm9017866 | |||
CHEMBL1092572 | 8282 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 472 | 6 | 1 | 4 | 3.6 | COCCN1C[C@H](c2ccc(F)cc2F)[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)C1 | 10.1021/jm9017866 | |||
90643830 | 111817 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 787 | 10 | 4 | 6 | 2.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287337 | 111817 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 787 | 10 | 4 | 6 | 2.2 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N1Cc2ccccc2CC1C(N)=O | 10.1021/jm500064t | |||
CHEMBL2304250 | 211945 | None | 0 | Mouse | Functional | pEC50 | = | 4.4 | 4.4 | -6 | 3 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O | 10.1021/jm0492756 | |||||
44409337 | 170564 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 721 | 19 | 7 | 6 | 3.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(O)cc1)NC(C)=O)Cc1ccccc1 | 10.1016/j.bmcl.2005.12.005 | |||
CHEMBL444883 | 170564 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 721 | 19 | 7 | 6 | 3.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(O)cc1)NC(C)=O)Cc1ccccc1 | 10.1016/j.bmcl.2005.12.005 | |||
44349019 | 114501 | None | 0 | Mouse | Functional | pEC50 | = | 7.4 | 7.4 | -1 | 2 | ChEMBL | 583 | 8 | 2 | 7 | 3.1 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cnnc2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL333283 | 114501 | None | 0 | Mouse | Functional | pEC50 | = | 7.4 | 7.4 | -1 | 2 | ChEMBL | 583 | 8 | 2 | 7 | 3.1 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cnnc2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1016/s0960-894x(03)00796-0 | |||
44394581 | 122215 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 12 | 3 | ChEMBL | 755 | 19 | 9 | 6 | 1.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)C1CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL359702 | 122215 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 12 | 3 | ChEMBL | 755 | 19 | 9 | 6 | 1.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)C1CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44322987 | 96785 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -8 | 3 | ChEMBL | 713 | 20 | 9 | 7 | 0.2 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL264306 | 96785 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -8 | 3 | ChEMBL | 713 | 20 | 9 | 7 | 0.2 | CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
44322788 | 157475 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -5 | 3 | ChEMBL | 699 | 19 | 9 | 7 | -0.2 | CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL407825 | 157475 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -5 | 3 | ChEMBL | 699 | 19 | 9 | 7 | -0.2 | CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
90643841 | 111826 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 828 | 15 | 7 | 6 | 1.9 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287348 | 111826 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 828 | 15 | 7 | 6 | 1.9 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
155563055 | 175399 | None | 0 | Mouse | Functional | pEC50 | = | 6.4 | 6.4 | -75 | 3 | ChEMBL | 686 | 18 | 9 | 7 | 0.5 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
CHEMBL4573041 | 175399 | None | 0 | Mouse | Functional | pEC50 | = | 6.4 | 6.4 | -75 | 3 | ChEMBL | 686 | 18 | 9 | 7 | 0.5 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O | 10.1021/acs.jmedchem.9b00053 | |||
9960253 | 117013 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 25 | 2 | ChEMBL | 595 | 8 | 3 | 6 | 2.8 | CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL338594 | 117013 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 25 | 2 | ChEMBL | 595 | 8 | 3 | 6 | 2.8 | CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/s0960-894x(03)00796-0 | |||
44349133 | 117348 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 665 | 11 | 2 | 6 | 3.8 | CC(C)CN(Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL339545 | 117348 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 665 | 11 | 2 | 6 | 3.8 | CC(C)CN(Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/s0960-894x(03)00796-0 | |||
137634090 | 156390 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -2 | 5 | ChEMBL | 3980 | 69 | 56 | 64 | -22.2 | CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N3)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N2 | 10.1021/acs.jmedchem.8b00251 | |||
CHEMBL4065418 | 156390 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -2 | 5 | ChEMBL | 3980 | 69 | 56 | 64 | -22.2 | CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N3)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N2 | 10.1021/acs.jmedchem.8b00251 | |||
155512534 | 169795 | None | 0 | Mouse | Functional | pEC50 | = | 5.4 | 5.4 | -42 | 3 | ChEMBL | 642 | 16 | 7 | 6 | 1.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.9b00198 | |||
CHEMBL4437801 | 169795 | None | 0 | Mouse | Functional | pEC50 | = | 5.4 | 5.4 | -42 | 3 | ChEMBL | 642 | 16 | 7 | 6 | 1.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acsmedchemlett.9b00198 | |||
46232221 | 201625 | None | 0 | Mouse | Functional | pEC50 | = | 5.4 | 5.4 | -1 | 3 | ChEMBL | 835 | 12 | 9 | 8 | -0.1 | N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
CHEMBL589516 | 201625 | None | 0 | Mouse | Functional | pEC50 | = | 5.4 | 5.4 | -1 | 3 | ChEMBL | 835 | 12 | 9 | 8 | -0.1 | N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2009.12.010 | |||
45487290 | 199236 | None | 0 | Mouse | Functional | pEC50 | = | 4.4 | 4.4 | -12 | 3 | ChEMBL | 579 | 17 | 9 | 7 | -1.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1c[nH]cn1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
CHEMBL565474 | 199236 | None | 0 | Mouse | Functional | pEC50 | = | 4.4 | 4.4 | -12 | 3 | ChEMBL | 579 | 17 | 9 | 7 | -1.2 | N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1c[nH]cn1)C(N)=O | 10.1016/j.bmcl.2009.07.025 | |||
11846844 | 140166 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 1 | 3 | ChEMBL | 678 | 15 | 5 | 6 | 3.6 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL380051 | 140166 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 1 | 3 | ChEMBL | 678 | 15 | 5 | 6 | 3.6 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
44405823 | 72992 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 907 | 21 | 8 | 7 | 4.9 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc2ccc3ccccc3c2)C(=O)Nc2ccccc2C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
CHEMBL200668 | 72992 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 907 | 21 | 8 | 7 | 4.9 | CCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc2ccc3ccccc3c2)C(=O)Nc2ccccc2C(N)=O)CC[C@H](c2ccccc2)CC1 | 10.1016/j.bmcl.2005.08.083 | |||
11421919 | 120045 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 585 | 8 | 2 | 5 | 4.0 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CN2CCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
CHEMBL349887 | 120045 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 585 | 8 | 2 | 5 | 4.0 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CN2CCCC2)CC1)[C@H]1Cc2ccccc2CN1 | 10.1021/jm0304109 | |||
44394654 | 124040 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 9 | 3 | ChEMBL | 775 | 20 | 8 | 7 | 1.7 | CSCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL362879 | 124040 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 9 | 3 | ChEMBL | 775 | 20 | 8 | 7 | 1.7 | CSCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44442978 | 153165 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 537 | 8 | 1 | 5 | 4.8 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4cccnc4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
CHEMBL397607 | 153165 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 537 | 8 | 1 | 5 | 4.8 | CC(C)N1C[C@H](c2ccc(Cl)cc2)[C@@H](C(=O)N2CCN(C3(CNCc4cccnc4)CCCCC3)CC2)C1 | 10.1016/j.bmcl.2007.10.032 | |||
44444448 | 94116 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 523 | 6 | 1 | 5 | 4.0 | CC(C)N1C[C@@H](C(=O)N2CCN(c3ccccc3CN3CCC(N)CC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL248964 | 94116 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 523 | 6 | 1 | 5 | 4.0 | CC(C)N1C[C@@H](C(=O)N2CCN(c3ccccc3CN3CCC(N)CC3)CC2)[C@H](c2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL105113 | 210925 | None | 0 | Mouse | Functional | pEC50 | = | 6.4 | 6.4 | -1 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm800291b | |||||
15953833 | 79005 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 8 | 4 | ChEMBL | 622 | 9 | 2 | 6 | 6.6 | COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)C2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
CHEMBL2113037 | 79005 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 8 | 4 | ChEMBL | 622 | 9 | 2 | 6 | 6.6 | COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)C2=O)cc1 | 10.1016/j.bmcl.2005.06.033 | |||
46865980 | 8470 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 470 | 3 | 1 | 3 | 4.8 | C[C@H]1CN(C(=O)C2CN(C(C)(C)C)CC2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL1093846 | 8470 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 470 | 3 | 1 | 3 | 4.8 | C[C@H]1CN(C(=O)C2CN(C(C)(C)C)CC2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
25131477 | 178806 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 547 | 10 | 2 | 5 | 2.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCN(C)C)C1=O | 10.1021/jm800525p | |||
CHEMBL468252 | 178806 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 547 | 10 | 2 | 5 | 2.2 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCN(C)C)C1=O | 10.1021/jm800525p | |||
CHEMBL5075506 | 216867 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -676 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
168296647 | 192584 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -213 | 4 | ChEMBL | 1319 | 15 | 14 | 15 | 0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccccc2CSC[C@@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.2c00793 | |||
CHEMBL5208830 | 192584 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -213 | 4 | ChEMBL | 1319 | 15 | 14 | 15 | 0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccccc2CSC[C@@H](C(N)=O)NC1=O | 10.1021/acs.jmedchem.2c00793 | |||
49792705 | 67524 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 422 | 4 | 1 | 4 | 5.5 | CC(=O)Nc1cc(-c2ccc(N(C)C)cc2)cn2c(-c3ccc(F)c(Cl)c3)cnc12 | nan | |||
CHEMBL1894685 | 67524 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 422 | 4 | 1 | 4 | 5.5 | CC(=O)Nc1cc(-c2ccc(N(C)C)cc2)cn2c(-c3ccc(F)c(Cl)c3)cnc12 | nan | |||
90643803 | 111806 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -3 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287323 | 111806 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -3 | 4 | ChEMBL | 898 | 18 | 9 | 7 | 0.4 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
46885558 | 7811 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 151 | 2 | ChEMBL | 492 | 4 | 1 | 5 | 4.0 | C[C@H]1CN(C(=O)[C@H]2CN(c3ccncn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
CHEMBL1089483 | 7811 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 151 | 2 | ChEMBL | 492 | 4 | 1 | 5 | 4.0 | C[C@H]1CN(C(=O)[C@H]2CN(c3ccncn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1 | 10.1021/jm9017866 | |||
46885483 | 8333 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 510 | 4 | 1 | 5 | 4.1 | C[C@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1 | 10.1021/jm9017866 | |||
CHEMBL1092861 | 8333 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 510 | 4 | 1 | 5 | 4.1 | C[C@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1 | 10.1021/jm9017866 | |||
CHEMBL1204053 | 8333 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 510 | 4 | 1 | 5 | 4.1 | C[C@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1 | 10.1021/jm9017866 | |||
15603023 | 98017 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | 849 | 12 | 10 | 8 | 0.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm701093y | |||
CHEMBL272660 | 98017 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | 849 | 12 | 10 | 8 | 0.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm701093y | |||
15602927 | 157974 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | 1 | 4 | ChEMBL | 835 | 12 | 10 | 8 | -0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm701093y | |||
CHEMBL408398 | 157974 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | 1 | 4 | ChEMBL | 835 | 12 | 10 | 8 | -0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm701093y | |||
16132144 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.5b01894 | |||||
16133793 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.5b01894 | |||||
44273719 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.5b01894 | |||||
CHEMBL214332 | 211738 | None | 29 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -8 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.5b01894 | |||||
44275263 | 162020 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 478 | 2 | ChEMBL | 1022 | 13 | 11 | 9 | 1.5 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3c(Cl)cccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
CHEMBL415341 | 162020 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 478 | 2 | ChEMBL | 1022 | 13 | 11 | 9 | 1.5 | CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCc3c(Cl)cccc3C2)NC1=O | 10.1016/s0960-894x(03)00114-8 | |||
1338 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/s0960-894x(03)00796-0 | |||
9938402 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/s0960-894x(03)00796-0 | |||
CHEMBL339053 | 3807 | None | 36 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -2 | 8 | ChEMBL | 588 | 8 | 2 | 6 | 4.6 | O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl | 10.1016/s0960-894x(03)00796-0 | |||
44390411 | 63917 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 609 | 8 | 2 | 6 | 2.8 | CN(c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/j.bmcl.2005.01.060 | |||
CHEMBL180487 | 63917 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 609 | 8 | 2 | 6 | 2.8 | CN(c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O | 10.1016/j.bmcl.2005.01.060 | |||
44404523 | 135449 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 882 | 22 | 9 | 7 | 3.1 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
CHEMBL372785 | 135449 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 882 | 22 | 9 | 7 | 3.1 | CCCCC(=O)N[C@]1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC(N)=O)CC[C@H](c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2005.08.012 | |||
10408 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
5329 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
9941379 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
9941379.0 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
CHEMBL2070241 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
DB11653 | 720 | None | 23 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C | 10.1021/acs.jmedchem.8b00170 | |||||
171378344 | 195064 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 12 | 3 | ChEMBL | 765 | 15 | 10 | 7 | 0.8 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CNC1=O | 10.1021/acs.jmedchem.2c01794 | |||
CHEMBL5395890 | 195064 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 12 | 3 | ChEMBL | 765 | 15 | 10 | 7 | 0.8 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CNC1=O | 10.1021/acs.jmedchem.2c01794 | |||
90643804 | 111807 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -8 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287324 | 111807 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -8 | 4 | ChEMBL | 839 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
52944242 | 18160 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 609 | 4 | 1 | 4 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)CC2C(C)(C)c1cnn[nH]1 | 10.1016/j.bmcl.2010.09.049 | |||
CHEMBL1269572 | 18160 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 609 | 4 | 1 | 4 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)CC2C(C)(C)c1cnn[nH]1 | 10.1016/j.bmcl.2010.09.049 | |||
56683297 | 63706 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 667 | 5 | 1 | 3 | 7.5 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NCC(F)(F)F | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801125 | 63706 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 667 | 5 | 1 | 3 | 7.5 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)NCC(F)(F)F | 10.1016/j.bmcl.2010.06.062 | |||
90643808 | 111810 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -14 | 4 | ChEMBL | 747 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287328 | 111810 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -14 | 4 | ChEMBL | 747 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
90643827 | 111814 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 920 | 15 | 7 | 6 | 1.9 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287334 | 111814 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 920 | 15 | 7 | 6 | 1.9 | CC(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL5092761 | 217878 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -295 | 4 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
56676631 | 63690 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 613 | 4 | 0 | 3 | 7.0 | CC(=O)N(C)C(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801093 | 63690 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 613 | 4 | 0 | 3 | 7.0 | CC(=O)N(C)C(C)(C)[C@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
56659468 | 63713 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 661 | 4 | 0 | 3 | 7.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CC(F)(F)C1 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1801145 | 63713 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 661 | 4 | 0 | 3 | 7.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)C[C@@H]2C(C)(C)C(=O)N1CC(F)(F)C1 | 10.1016/j.bmcl.2010.06.062 | |||
44413931 | 78044 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 9 | 3 | ChEMBL | 643 | 16 | 5 | 6 | 1.9 | CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
CHEMBL209789 | 78044 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 9 | 3 | ChEMBL | 643 | 16 | 5 | 6 | 1.9 | CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N | 10.1021/jm060384p | |||
90643806 | 111809 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287326 | 111809 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -12 | 4 | ChEMBL | 728 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
90643805 | 111808 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287325 | 111808 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL307457 | 213440 | None | 0 | Mouse | Functional | pEC50 | = | 8.4 | 8.4 | -10 | 3 | ChEMBL | None | None | None | CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm010061n | |||||
CHEMBL5080489 | 217177 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 1 | 4 | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N2 | 10.1021/acs.jmedchem.1c00095 | |||||
90643808 | 111810 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -14 | 4 | ChEMBL | 747 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287328 | 111810 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -14 | 4 | ChEMBL | 747 | 16 | 7 | 8 | 1.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
90643805 | 111808 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287325 | 111808 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 1 | 4 | ChEMBL | 917 | 20 | 11 | 7 | -0.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O | 10.1021/jm500064t | |||
90643802 | 111805 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
CHEMBL3287322 | 111805 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -14 | 4 | ChEMBL | 820 | 14 | 5 | 8 | 1.9 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O | 10.1021/jm500064t | |||
44448590 | 95652 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 25 | 3 | ChEMBL | 571 | 7 | 1 | 4 | 6.3 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(OC)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
CHEMBL257759 | 95652 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 25 | 3 | ChEMBL | 571 | 7 | 1 | 4 | 6.3 | CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(OC)cc2F)CC1 | 10.1016/j.bmcl.2008.04.049 | |||
11753695 | 8395 | None | 6 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -3 | 7 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
CHEMBL1093304 | 8395 | None | 6 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -3 | 7 | ChEMBL | 599 | 4 | 1 | 3 | 6.7 | CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21 | 10.1016/j.bmcl.2010.06.062 | |||
24180493 | 155214 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 635 | 10 | 2 | 5 | 5.7 | CC(C)C[C@H](NC(=O)CCN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.06.088 | |||
CHEMBL402043 | 155214 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 635 | 10 | 2 | 5 | 5.7 | CC(C)C[C@H](NC(=O)CCN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H]2CN(C(C)C)C[C@H]2c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.06.088 | |||
44394623 | 141625 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 1 | 2 | ChEMBL | 936 | 26 | 11 | 8 | 2.4 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
CHEMBL384720 | 141625 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 1 | 2 | ChEMBL | 936 | 26 | 11 | 8 | 2.4 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.bmcl.2004.07.046 | |||
44322896 | 168075 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 1 | 2 | ChEMBL | 789 | 22 | 10 | 7 | 1.6 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
CHEMBL431801 | 168075 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 1 | 2 | ChEMBL | 789 | 22 | 10 | 7 | 1.6 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(03)00552-3 | |||
155551699 | 175244 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1680 | 54 | 21 | 19 | -0.0 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
CHEMBL4569886 | 175244 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1680 | 54 | 21 | 19 | -0.0 | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b00238 | |||
57817763 | 76955 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1988 | 59 | 26 | 26 | -3.2 | CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
70690940 | 76955 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1988 | 59 | 26 | 26 | -3.2 | CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
91929808 | 76955 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1988 | 59 | 26 | 26 | -3.2 | CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
CHEMBL2070251 | 76955 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1988 | 59 | 26 | 26 | -3.2 | CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O | 10.1021/jm201489a | |||
11296600 | 123009 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 628 | 9 | 4 | 6 | 3.8 | CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.03.053 | |||
CHEMBL360716 | 123009 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 628 | 9 | 4 | 6 | 3.8 | CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2005.03.053 | |||
11296600 | 123009 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 628 | 9 | 4 | 6 | 3.8 | CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
CHEMBL360716 | 123009 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 628 | 9 | 4 | 6 | 3.8 | CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | 10.1016/j.bmcl.2004.06.059 | |||
11753695 | 8395 | None | 6 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -3 | 7 |