Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	2583	208352	None	32	Human	Functional	pAC50	=	9	9.0	6	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	2583.0	208352	None	32	Human	Functional	pAC50	=	9	9.0	6	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	CHEMBL839	208352	None	32	Human	Functional	pAC50	=	9	9.0	6	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	DB00521	208352	None	32	Human	Functional	pAC50	=	9	9.0	6	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	1978	250	None	42	Human	Functional	pAC50	=	6	6.0	28	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	1978.0	250	None	42	Human	Functional	pAC50	=	6	6.0	28	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	40	250	None	42	Human	Functional	pAC50	=	6	6.0	28	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	7107	250	None	42	Human	Functional	pAC50	=	6	6.0	28	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	CHEMBL642	250	None	42	Human	Functional	pAC50	=	6	6.0	28	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	DB01193	250	None	42	Human	Functional	pAC50	=	6	6.0	28	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	10184665	3991	None	42	Human	Functional	pAC50	=	5	5.0	-173	10	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	10184665.0	3991	None	42	Human	Functional	pAC50	=	5	5.0	-173	10	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3991	None	42	Human	Functional	pAC50	=	5	5.0	-173	10	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3991	None	42	Human	Functional	pAC50	=	5	5.0	-173	10	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3991	None	42	Human	Functional	pAC50	=	5	5.0	-173	10	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3991	None	42	Human	Functional	pAC50	=	5	5.0	-173	10	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	216416	111644	None	40	Human	Functional	pAC50	=	5	5.0	-117	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111644	None	40	Human	Functional	pAC50	=	5	5.0	-117	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	11823027	192725	None	29	Human	Functional	pAC50	=	7.0	7.0	-5	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	11823027.0	192725	None	29	Human	Functional	pAC50	=	7.0	7.0	-5	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	4411	192725	None	29	Human	Functional	pAC50	=	7.0	7.0	-5	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	4411.0	192725	None	29	Human	Functional	pAC50	=	7.0	7.0	-5	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	CHEMBL3246778	192725	None	29	Human	Functional	pAC50	=	7.0	7.0	-5	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	CHEMBL521606	192725	None	29	Human	Functional	pAC50	=	7.0	7.0	-5	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	DB01203	192725	None	29	Human	Functional	pAC50	=	7.0	7.0	-5	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	72093	35070	None	5	Human	Functional	pAC50	=	5.0	5.0	-10	28	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35070	None	5	Human	Functional	pAC50	=	5.0	5.0	-10	28	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35070	None	5	Human	Functional	pAC50	=	5.0	5.0	-10	28	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4418	34231	None	58	Human	Functional	pAC50	=	6.0	6.0	-19	18	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	4418.0	34231	None	58	Human	Functional	pAC50	=	6.0	6.0	-19	18	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34231	None	58	Human	Functional	pAC50	=	6.0	6.0	-19	18	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	DB12092	34231	None	58	Human	Functional	pAC50	=	6.0	6.0	-19	18	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	12582	950	None	27	Human	Functional	pAC50	=	7.0	7.0	-1	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	2783	950	None	27	Human	Functional	pAC50	=	7.0	7.0	-1	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	2783.0	950	None	27	Human	Functional	pAC50	=	7.0	7.0	-1	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	CHEMBL49080	950	None	27	Human	Functional	pAC50	=	7.0	7.0	-1	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	DB01407	950	None	27	Human	Functional	pAC50	=	7.0	7.0	-1	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	3083544	26817	None	34	Human	Functional	pAC50	=	6.0	6.0	-199	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	3083544.0	26817	None	34	Human	Functional	pAC50	=	6.0	6.0	-199	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1200811	26817	None	34	Human	Functional	pAC50	=	6.0	6.0	-199	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1363	26817	None	34	Human	Functional	pAC50	=	6.0	6.0	-199	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1951071	26817	None	34	Human	Functional	pAC50	=	6.0	6.0	-199	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL605993	26817	None	34	Human	Functional	pAC50	=	6.0	6.0	-199	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	DB00983	26817	None	34	Human	Functional	pAC50	=	6.0	6.0	-199	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	DB01274	26817	None	34	Human	Functional	pAC50	=	6.0	6.0	-199	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	100	3805	None	44	Human	Functional	pAC50	=	4.9	4.9	-2754	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	None	44	Human	Functional	pAC50	=	4.9	4.9	-2754	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	None	44	Human	Functional	pAC50	=	4.9	4.9	-2754	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	None	44	Human	Functional	pAC50	=	4.9	4.9	-2754	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	None	44	Human	Functional	pAC50	=	4.9	4.9	-2754	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	11980903	14498	None	13	Human	Functional	pAC50	=	4.9	4.9	-354	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	22526	14498	None	13	Human	Functional	pAC50	=	4.9	4.9	-354	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	5281035	14498	None	13	Human	Functional	pAC50	=	4.9	4.9	-354	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201303	14498	None	13	Human	Functional	pAC50	=	4.9	4.9	-354	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	2713	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-2	27	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-2	27	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-2	27	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-2	27	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-2	27	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-2	27	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-2	27	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	6436135	99626	None	31	Human	Functional	pAC50	=	4.9	4.9	-1	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	9	2	4	5.8	CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL283754	99626	None	31	Human	Functional	pAC50	=	4.9	4.9	-1	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	9	2	4	5.8	CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O	10.1038/s41467-023-40064-9
	5906	14501	None	15	Human	Functional	pAC50	=	4.8	4.8	-1	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	5906.0	14501	None	15	Human	Functional	pAC50	=	4.8	4.8	-1	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14501	None	15	Human	Functional	pAC50	=	4.8	4.8	-1	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	DB00610	14501	None	15	Human	Functional	pAC50	=	4.8	4.8	-1	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	202	1508	None	46	Human	Functional	pAC50	=	4.8	4.8	-10	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1508	None	46	Human	Functional	pAC50	=	4.8	4.8	-10	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1508	None	46	Human	Functional	pAC50	=	4.8	4.8	-10	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1508	None	46	Human	Functional	pAC50	=	4.8	4.8	-10	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1508	None	46	Human	Functional	pAC50	=	4.8	4.8	-10	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3191	102913	None	65	Human	Functional	pAC50	=	4.8	4.8	-831	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	3191.0	102913	None	65	Human	Functional	pAC50	=	4.8	4.8	-831	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL305660	102913	None	65	Human	Functional	pAC50	=	4.8	4.8	-831	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	DB11742	102913	None	65	Human	Functional	pAC50	=	4.8	4.8	-831	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	1786	2520	None	51	Human	Functional	pAC50	=	5.8	5.8	-10	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	4171	2520	None	51	Human	Functional	pAC50	=	5.8	5.8	-10	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	4171.0	2520	None	51	Human	Functional	pAC50	=	5.8	5.8	-10	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	553	2520	None	51	Human	Functional	pAC50	=	5.8	5.8	-10	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL13	2520	None	51	Human	Functional	pAC50	=	5.8	5.8	-10	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00264	2520	None	51	Human	Functional	pAC50	=	5.8	5.8	-10	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	6436173	55132	None	30	Human	Functional	pAC50	=	4.8	4.8	-4	22	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL1617	55132	None	30	Human	Functional	pAC50	=	4.8	4.8	-4	22	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	2274	3173	None	38	Human	Functional	pAC50	=	4.8	4.8	-1047	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3173	None	38	Human	Functional	pAC50	=	4.8	4.8	-1047	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917.0	3173	None	38	Human	Functional	pAC50	=	4.8	4.8	-1047	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3173	None	38	Human	Functional	pAC50	=	4.8	4.8	-1047	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3173	None	38	Human	Functional	pAC50	=	4.8	4.8	-1047	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3173	None	38	Human	Functional	pAC50	=	4.8	4.8	-1047	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3464	3172	None	21	Human	Functional	pAC50	=	4.8	4.8	-1348	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	290	5	4	4	2.0	CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C	10.1038/s41467-023-40064-9
	4916	3172	None	21	Human	Functional	pAC50	=	4.8	4.8	-1348	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	290	5	4	4	2.0	CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C	10.1038/s41467-023-40064-9
	4916.0	3172	None	21	Human	Functional	pAC50	=	4.8	4.8	-1348	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	290	5	4	4	2.0	CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C	10.1038/s41467-023-40064-9
	CHEMBL160519	3172	None	21	Human	Functional	pAC50	=	4.8	4.8	-1348	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	290	5	4	4	2.0	CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C	10.1038/s41467-023-40064-9
	DB01366	3172	None	21	Human	Functional	pAC50	=	4.8	4.8	-1348	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	290	5	4	4	2.0	CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C	10.1038/s41467-023-40064-9
	31729	208242	None	9	Human	Functional	pAC50	=	4.8	4.8	-707	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	287	6	4	4	2.4	CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL83063	208242	None	9	Human	Functional	pAC50	=	4.8	4.8	-707	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	287	6	4	4	2.4	CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	3926	209699	None	30	Human	Functional	pAC50	=	4.8	4.8	-27	18	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	209699	None	30	Human	Functional	pAC50	=	4.8	4.8	-27	18	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	1016	3747	None	45	Human	Functional	pAC50	=	4.8	4.8	-2344	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2561	3747	None	45	Human	Functional	pAC50	=	4.8	4.8	-2344	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2733526	3747	None	45	Human	Functional	pAC50	=	4.8	4.8	-2344	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	5384	3747	None	45	Human	Functional	pAC50	=	4.8	4.8	-2344	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL83	3747	None	45	Human	Functional	pAC50	=	4.8	4.8	-2344	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	DB00675	3747	None	45	Human	Functional	pAC50	=	4.8	4.8	-2344	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2267	559	None	45	Human	Functional	pAC50	=	4.8	4.8	-741	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2267.0	559	None	45	Human	Functional	pAC50	=	4.8	4.8	-741	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	None	45	Human	Functional	pAC50	=	4.8	4.8	-741	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	None	45	Human	Functional	pAC50	=	4.8	4.8	-741	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	None	45	Human	Functional	pAC50	=	4.8	4.8	-741	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	None	45	Human	Functional	pAC50	=	4.8	4.8	-741	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2435	3590	None	59	Human	Functional	pAC50	=	4.8	4.8	-4365	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3590	None	59	Human	Functional	pAC50	=	4.8	4.8	-4365	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3590	None	59	Human	Functional	pAC50	=	4.8	4.8	-4365	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3590	None	59	Human	Functional	pAC50	=	4.8	4.8	-4365	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3590	None	59	Human	Functional	pAC50	=	4.8	4.8	-4365	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	2540	4402	None	68	Human	Functional	pAC50	=	4.8	4.8	-2570	28	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4402	None	68	Human	Functional	pAC50	=	4.8	4.8	-2570	28	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	64139	84819	None	58	Human	Functional	pAC50	=	4.7	4.7	-3	9	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	0	1	2	4.1	O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1	10.1038/s41467-023-40064-9
	CHEMBL223228	84819	None	58	Human	Functional	pAC50	=	4.7	4.7	-3	9	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	0	1	2	4.1	O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1	10.1038/s41467-023-40064-9
	451668	14463	None	65	Human	Functional	pAC50	=	4.7	4.7	-	1	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	228	2	3	8	-2.1	Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1	10.1038/s41467-023-40064-9
	CHEMBL1201129	14463	None	65	Human	Functional	pAC50	=	4.7	4.7	-	1	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	228	2	3	8	-2.1	Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1	10.1038/s41467-023-40064-9
	33624	3821	None	21	Human	Functional	pAC50	=	8.6	8.6	-5	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	33624.0	3821	None	21	Human	Functional	pAC50	=	8.6	8.6	-5	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	4061	3821	None	21	Human	Functional	pAC50	=	8.6	8.6	-5	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	565	3821	None	21	Human	Functional	pAC50	=	8.6	8.6	-5	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL499	3821	None	21	Human	Functional	pAC50	=	8.6	8.6	-5	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	DB00373	3821	None	21	Human	Functional	pAC50	=	8.6	8.6	-5	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	1222	1664	None	37	Human	Functional	pAC50	=	4.7	4.7	-467	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1664	None	37	Human	Functional	pAC50	=	4.7	4.7	-467	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396.0	1664	None	37	Human	Functional	pAC50	=	4.7	4.7	-467	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1664	None	37	Human	Functional	pAC50	=	4.7	4.7	-467	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1664	None	37	Human	Functional	pAC50	=	4.7	4.7	-467	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1664	None	37	Human	Functional	pAC50	=	4.7	4.7	-467	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	1836	2592	None	44	Human	Functional	pAC50	=	4.7	4.7	-39810	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	3340	2592	None	44	Human	Functional	pAC50	=	4.7	4.7	-39810	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	5281040	2592	None	44	Human	Functional	pAC50	=	4.7	4.7	-39810	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	5281040.0	2592	None	44	Human	Functional	pAC50	=	4.7	4.7	-39810	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	CHEMBL787	2592	None	44	Human	Functional	pAC50	=	4.7	4.7	-39810	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	DB00471	2592	None	44	Human	Functional	pAC50	=	4.7	4.7	-39810	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	5591	157623	None	57	Human	Functional	pAC50	=	4.7	4.7	-12	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157623	None	57	Human	Functional	pAC50	=	4.7	4.7	-12	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	3151	1462	None	65	Human	Functional	pAC50	=	4.7	4.7	-7585	24	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3151.0	1462	None	65	Human	Functional	pAC50	=	4.7	4.7	-7585	24	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1462	None	65	Human	Functional	pAC50	=	4.7	4.7	-7585	24	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1462	None	65	Human	Functional	pAC50	=	4.7	4.7	-7585	24	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1462	None	65	Human	Functional	pAC50	=	4.7	4.7	-7585	24	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1462	None	65	Human	Functional	pAC50	=	4.7	4.7	-7585	24	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2303	3187	None	44	Human	Functional	pAC50	=	7.7	7.7	-6	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4946	3187	None	44	Human	Functional	pAC50	=	7.7	7.7	-6	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	564	3187	None	44	Human	Functional	pAC50	=	7.7	7.7	-6	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	63	3187	None	44	Human	Functional	pAC50	=	7.7	7.7	-6	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	91536	3187	None	44	Human	Functional	pAC50	=	7.7	7.7	-6	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL27	3187	None	44	Human	Functional	pAC50	=	7.7	7.7	-6	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL452861	3187	None	44	Human	Functional	pAC50	=	7.7	7.7	-6	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00571	3187	None	44	Human	Functional	pAC50	=	7.7	7.7	-6	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	5282219	35878	None	48	Human	Functional	pAC50	=	4.7	4.7	-3	9	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	450	12	1	5	5.7	CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1441961	35878	None	48	Human	Functional	pAC50	=	4.7	4.7	-3	9	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	450	12	1	5	5.7	CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1	10.1038/s41467-023-40064-9
	105	3461	None	54	Human	Functional	pAC50	=	4.7	4.7	-28	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	2083	3461	None	54	Human	Functional	pAC50	=	4.7	4.7	-28	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	2083.0	3461	None	54	Human	Functional	pAC50	=	4.7	4.7	-28	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	558	3461	None	54	Human	Functional	pAC50	=	4.7	4.7	-28	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL714	3461	None	54	Human	Functional	pAC50	=	4.7	4.7	-28	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	DB01001	3461	None	54	Human	Functional	pAC50	=	4.7	4.7	-28	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	11976	920	None	44	Human	Functional	pAC50	=	4.7	4.7	-7244	16	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	667467	920	None	44	Human	Functional	pAC50	=	4.7	4.7	-7244	16	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	667467.0	920	None	44	Human	Functional	pAC50	=	4.7	4.7	-7244	16	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	CHEMBL908	920	None	44	Human	Functional	pAC50	=	4.7	4.7	-7244	16	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	DB01239	920	None	44	Human	Functional	pAC50	=	4.7	4.7	-7244	16	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	155774	4096	None	34	Human	Functional	pAC50	=	6.7	6.7	38	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1038/s41467-023-40064-9
	2848	4096	None	34	Human	Functional	pAC50	=	6.7	6.7	38	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1038/s41467-023-40064-9
	538	4096	None	34	Human	Functional	pAC50	=	6.7	6.7	38	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL75753	4096	None	34	Human	Functional	pAC50	=	6.7	6.7	38	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1038/s41467-023-40064-9
	DB13781	4096	None	34	Human	Functional	pAC50	=	6.7	6.7	38	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1038/s41467-023-40064-9
	180	401	None	38	Human	Functional	pAC50	=	4.6	4.6	-48977	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	38	Human	Functional	pAC50	=	4.6	4.6	-48977	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	38	Human	Functional	pAC50	=	4.6	4.6	-48977	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160.0	401	None	38	Human	Functional	pAC50	=	4.6	4.6	-48977	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	38	Human	Functional	pAC50	=	4.6	4.6	-48977	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	38	Human	Functional	pAC50	=	4.6	4.6	-48977	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3689	102826	None	36	Human	Functional	pAC50	=	4.6	4.6	-3311	16	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102826	None	36	Human	Functional	pAC50	=	4.6	4.6	-3311	16	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102826	None	36	Human	Functional	pAC50	=	4.6	4.6	-3311	16	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	1971	2866	None	32	Human	Functional	pAC50	=	4.6	4.6	-33113	32	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2866	None	32	Human	Functional	pAC50	=	4.6	4.6	-33113	32	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2866	None	32	Human	Functional	pAC50	=	4.6	4.6	-33113	32	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543.0	2866	None	32	Human	Functional	pAC50	=	4.6	4.6	-33113	32	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2866	None	32	Human	Functional	pAC50	=	4.6	4.6	-33113	32	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2866	None	32	Human	Functional	pAC50	=	4.6	4.6	-33113	32	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	5482	14425	None	55	Human	Functional	pAC50	=	4.6	4.6	-13	13	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1200438	14425	None	55	Human	Functional	pAC50	=	4.6	4.6	-13	13	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2419	3463	None	53	Human	Functional	pAC50	=	5.6	5.6	-977	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152	3463	None	53	Human	Functional	pAC50	=	5.6	5.6	-977	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152.0	3463	None	53	Human	Functional	pAC50	=	5.6	5.6	-977	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	559	3463	None	53	Human	Functional	pAC50	=	5.6	5.6	-977	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL1263	3463	None	53	Human	Functional	pAC50	=	5.6	5.6	-977	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB00938	3463	None	53	Human	Functional	pAC50	=	5.6	5.6	-977	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	129211	3749	None	48	Human	Functional	pAC50	=	5.6	5.6	-5495	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	129211.0	3749	None	48	Human	Functional	pAC50	=	5.6	5.6	-5495	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3749	None	48	Human	Functional	pAC50	=	5.6	5.6	-5495	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3749	None	48	Human	Functional	pAC50	=	5.6	5.6	-5495	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3749	None	48	Human	Functional	pAC50	=	5.6	5.6	-5495	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3749	None	48	Human	Functional	pAC50	=	5.6	5.6	-5495	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	26987	949	None	27	Human	Functional	pAC50	=	4.6	4.6	-21877	34	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	26987.0	949	None	27	Human	Functional	pAC50	=	4.6	4.6	-21877	34	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	949	None	27	Human	Functional	pAC50	=	4.6	4.6	-21877	34	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	949	None	27	Human	Functional	pAC50	=	4.6	4.6	-21877	34	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	949	None	27	Human	Functional	pAC50	=	4.6	4.6	-21877	34	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	949	None	27	Human	Functional	pAC50	=	4.6	4.6	-21877	34	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	4640	78295	None	23	Human	Functional	pAC50	=	4.6	4.6	-218	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78295	None	23	Human	Functional	pAC50	=	4.6	4.6	-218	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	4486	123049	None	18	Human	Functional	pAC50	=	4.6	4.6	-	1	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	11	2	9	0.3	Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O	10.1038/s41467-023-40064-9
	CHEMBL360861	123049	None	18	Human	Functional	pAC50	=	4.6	4.6	-	1	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	11	2	9	0.3	Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O	10.1038/s41467-023-40064-9
	1549120	198942	None	55	Human	Functional	pAC50	=	4.6	4.6	-17	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL56337	198942	None	55	Human	Functional	pAC50	=	4.6	4.6	-17	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
	2372	106524	None	30	Human	Functional	pAC50	=	7.6	7.6	12	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL314010	106524	None	30	Human	Functional	pAC50	=	7.6	7.6	12	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	5606	10195	None	41	Human	Functional	pAC50	=	5.6	5.6	-3	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	227	3	2	2	2.8	CC(C)(C)NCC(O)c1ccccc1Cl	10.1038/s41467-023-40064-9
	5606.0	10195	None	41	Human	Functional	pAC50	=	5.6	5.6	-3	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	227	3	2	2	2.8	CC(C)(C)NCC(O)c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1159717	10195	None	41	Human	Functional	pAC50	=	5.6	5.6	-3	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	227	3	2	2	2.8	CC(C)(C)NCC(O)c1ccccc1Cl	10.1038/s41467-023-40064-9
	DB12248	10195	None	41	Human	Functional	pAC50	=	5.6	5.6	-3	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	227	3	2	2	2.8	CC(C)(C)NCC(O)c1ccccc1Cl	10.1038/s41467-023-40064-9
	65948	18563	None	62	Human	Functional	pAC50	=	4.6	4.6	-12	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	582	9	2	9	4.7	CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1	10.1038/s41467-023-40064-9
	CHEMBL1275868	18563	None	62	Human	Functional	pAC50	=	4.6	4.6	-12	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	582	9	2	9	4.7	CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1	10.1038/s41467-023-40064-9
	4908	188914	None	51	Human	Functional	pAC50	=	4.6	4.6	-5	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
	CHEMBL506	188914	None	51	Human	Functional	pAC50	=	4.6	4.6	-5	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
	4452	2762	None	13	Human	Functional	pAC50	=	5.6	5.6	-8912	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2762	None	13	Human	Functional	pAC50	=	5.6	5.6	-8912	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2762	None	13	Human	Functional	pAC50	=	5.6	5.6	-8912	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	2470	3653	None	40	Human	Functional	pAC50	=	5.6	5.6	-46773	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	None	40	Human	Functional	pAC50	=	5.6	5.6	-46773	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	None	40	Human	Functional	pAC50	=	5.6	5.6	-46773	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	None	40	Human	Functional	pAC50	=	5.6	5.6	-46773	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	None	40	Human	Functional	pAC50	=	5.6	5.6	-46773	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	216239	23803	None	71	Human	Functional	pAC50	=	4.6	4.6	-15	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1200485	23803	None	71	Human	Functional	pAC50	=	4.6	4.6	-15	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1336	23803	None	71	Human	Functional	pAC50	=	4.6	4.6	-15	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	3760	50314	None	27	Human	Functional	pAC50	=	4.6	4.6	-3	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	414	6	0	3	6.5	Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1571863	50314	None	27	Human	Functional	pAC50	=	4.6	4.6	-3	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	414	6	0	3	6.5	Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	30323	62505	None	35	Human	Functional	pAC50	=	4.6	4.6	-14	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL1563	62505	None	35	Human	Functional	pAC50	=	4.6	4.6	-14	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL178	62505	None	35	Human	Functional	pAC50	=	4.6	4.6	-14	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	135398735	137055	None	20	Human	Functional	pAC50	=	4.6	4.6	-12	28	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	136262914	137055	None	20	Human	Functional	pAC50	=	4.6	4.6	-12	28	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL374478	137055	None	20	Human	Functional	pAC50	=	4.6	4.6	-12	28	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	176	398	None	47	Human	Functional	pAC50	=	5.5	5.5	-4	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2157	398	None	47	Human	Functional	pAC50	=	5.5	5.5	-4	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2157.0	398	None	47	Human	Functional	pAC50	=	5.5	5.5	-4	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2566	398	None	47	Human	Functional	pAC50	=	5.5	5.5	-4	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	CHEMBL633	398	None	47	Human	Functional	pAC50	=	5.5	5.5	-4	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	DB01118	398	None	47	Human	Functional	pAC50	=	5.5	5.5	-4	40	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2333	142422	None	66	Human	Functional	pAC50	=	4.5	4.5	-25	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142422	None	66	Human	Functional	pAC50	=	4.5	4.5	-25	14	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	118422671	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	189562	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	189562.0	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301.0	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	9844194	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	9844194.0	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL2365658	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL3526436	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2757	None	41	Human	Functional	pAC50	=	8.5	8.5	22	23	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	2585	803	None	59	Human	Functional	pAC50	=	8.5	8.5	1	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	2585.0	803	None	59	Human	Functional	pAC50	=	8.5	8.5	1	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	803	None	59	Human	Functional	pAC50	=	8.5	8.5	1	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	803	None	59	Human	Functional	pAC50	=	8.5	8.5	1	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	803	None	59	Human	Functional	pAC50	=	8.5	8.5	1	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	803	None	59	Human	Functional	pAC50	=	8.5	8.5	1	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	3149	12618	None	11	Human	Functional	pAC50	=	5.5	5.5	-8	26	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12618	None	11	Human	Functional	pAC50	=	5.5	5.5	-8	26	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	2601	3780	None	25	Human	Functional	pAC50	=	5.5	5.5	-1023	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3780	None	25	Human	Functional	pAC50	=	5.5	5.5	-1023	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3780	None	25	Human	Functional	pAC50	=	5.5	5.5	-1023	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3780	None	25	Human	Functional	pAC50	=	5.5	5.5	-1023	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3780	None	25	Human	Functional	pAC50	=	5.5	5.5	-1023	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	5311064	1366	None	35	Human	Functional	pAC50	=	5.5	5.5	3	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	534	1366	None	35	Human	Functional	pAC50	=	5.5	5.5	3	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	806	1366	None	35	Human	Functional	pAC50	=	5.5	5.5	3	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL493682	1366	None	35	Human	Functional	pAC50	=	5.5	5.5	3	7	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	150	2509	None	14	Human	Functional	pAC50	=	5.4	5.4	-1445	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2509	None	14	Human	Functional	pAC50	=	5.4	5.4	-1445	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2509	None	14	Human	Functional	pAC50	=	5.4	5.4	-1445	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226.0	2509	None	14	Human	Functional	pAC50	=	5.4	5.4	-1445	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2509	None	14	Human	Functional	pAC50	=	5.4	5.4	-1445	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2509	None	14	Human	Functional	pAC50	=	5.4	5.4	-1445	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	2291	3184	None	43	Human	Functional	pAC50	=	6.4	6.4	-6	13	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	2561	3184	None	43	Human	Functional	pAC50	=	6.4	6.4	-6	13	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	4932	3184	None	43	Human	Functional	pAC50	=	6.4	6.4	-6	13	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	4932.0	3184	None	43	Human	Functional	pAC50	=	6.4	6.4	-6	13	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL631	3184	None	43	Human	Functional	pAC50	=	6.4	6.4	-6	13	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB01182	3184	None	43	Human	Functional	pAC50	=	6.4	6.4	-6	13	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	2464	3640	None	36	Human	Functional	pAC50	=	5.4	5.4	-7	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	5253	3640	None	36	Human	Functional	pAC50	=	5.4	5.4	-7	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	5253.0	3640	None	36	Human	Functional	pAC50	=	5.4	5.4	-7	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	7297	3640	None	36	Human	Functional	pAC50	=	5.4	5.4	-7	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL471	3640	None	36	Human	Functional	pAC50	=	5.4	5.4	-7	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	DB00489	3640	None	36	Human	Functional	pAC50	=	5.4	5.4	-7	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	4567	9950	None	29	Human	Functional	pAC50	=	5.4	5.4	-72	12	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9950	None	29	Human	Functional	pAC50	=	5.4	5.4	-72	12	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	2176	3127	None	40	Human	Functional	pAC50	=	8.4	8.4	1	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	4828	3127	None	40	Human	Functional	pAC50	=	8.4	8.4	1	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	4828.0	3127	None	40	Human	Functional	pAC50	=	8.4	8.4	1	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	91	3127	None	40	Human	Functional	pAC50	=	8.4	8.4	1	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL500	3127	None	40	Human	Functional	pAC50	=	8.4	8.4	1	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00960	3127	None	40	Human	Functional	pAC50	=	8.4	8.4	1	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	44112	121354	None	36	Human	Functional	pAC50	=	8.3	8.3	-1	12	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121354	None	36	Human	Functional	pAC50	=	8.3	8.3	-1	12	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	9931954	10938	None	59	Human	Functional	pAC50	=	4.4	4.4	-3	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	323	3	3	2	3.0	CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1173055	10938	None	59	Human	Functional	pAC50	=	4.4	4.4	-3	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	323	3	3	2	3.0	CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1	10.1038/s41467-023-40064-9
	3486	3157	None	44	Human	Functional	pAC50	=	5.3	5.3	-1	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1038/s41467-023-40064-9
	4883	3157	None	44	Human	Functional	pAC50	=	5.3	5.3	-1	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1038/s41467-023-40064-9
	555	3157	None	44	Human	Functional	pAC50	=	5.3	5.3	-1	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL6995	3157	None	44	Human	Functional	pAC50	=	5.3	5.3	-1	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1038/s41467-023-40064-9
	DB01297	3157	None	44	Human	Functional	pAC50	=	5.3	5.3	-1	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1038/s41467-023-40064-9
	25382	9159	None	27	Human	Functional	pAC50	=	5.3	5.3	-141	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9159	None	27	Human	Functional	pAC50	=	5.3	5.3	-141	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	36811	1454	None	27	Human	Functional	pAC50	=	5.3	5.3	-11	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	36811.0	1454	None	27	Human	Functional	pAC50	=	5.3	5.3	-11	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	535	1454	None	27	Human	Functional	pAC50	=	5.3	5.3	-11	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	937	1454	None	27	Human	Functional	pAC50	=	5.3	5.3	-11	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL926	1454	None	27	Human	Functional	pAC50	=	5.3	5.3	-11	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00841	1454	None	27	Human	Functional	pAC50	=	5.3	5.3	-11	17	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	16362	3125	None	49	Human	Functional	pAC50	=	5.3	5.3	-616	35	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	16362.0	3125	None	49	Human	Functional	pAC50	=	5.3	5.3	-616	35	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3125	None	49	Human	Functional	pAC50	=	5.3	5.3	-616	35	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3125	None	49	Human	Functional	pAC50	=	5.3	5.3	-616	35	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3125	None	49	Human	Functional	pAC50	=	5.3	5.3	-616	35	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3125	None	49	Human	Functional	pAC50	=	5.3	5.3	-616	35	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2318	154946	None	18	Human	Functional	pAC50	=	5.2	5.2	-8	15	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154946	None	18	Human	Functional	pAC50	=	5.2	5.2	-8	15	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	11504295	2923	None	40	Human	Functional	pAC50	=	6.2	6.2	-954	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	11504295.0	2923	None	40	Human	Functional	pAC50	=	6.2	6.2	-954	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2923	None	40	Human	Functional	pAC50	=	6.2	6.2	-954	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2923	None	40	Human	Functional	pAC50	=	6.2	6.2	-954	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2923	None	40	Human	Functional	pAC50	=	6.2	6.2	-954	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2923	None	40	Human	Functional	pAC50	=	6.2	6.2	-954	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2398	954	None	43	Human	Functional	pAC50	=	5.2	5.2	-4265	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	954	None	43	Human	Functional	pAC50	=	5.2	5.2	-4265	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801.0	954	None	43	Human	Functional	pAC50	=	5.2	5.2	-4265	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	954	None	43	Human	Functional	pAC50	=	5.2	5.2	-4265	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	954	None	43	Human	Functional	pAC50	=	5.2	5.2	-4265	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	954	None	43	Human	Functional	pAC50	=	5.2	5.2	-4265	36	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1499	2091	None	34	Human	Functional	pAC50	=	6.2	6.2	-58	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	3779	2091	None	34	Human	Functional	pAC50	=	6.2	6.2	-58	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	3779.0	2091	None	34	Human	Functional	pAC50	=	6.2	6.2	-58	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	536	2091	None	34	Human	Functional	pAC50	=	6.2	6.2	-58	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	CHEMBL434	2091	None	34	Human	Functional	pAC50	=	6.2	6.2	-58	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	DB01064	2091	None	34	Human	Functional	pAC50	=	6.2	6.2	-58	38	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	137	370	None	37	Human	Functional	pAC50	=	8.2	8.2	-3	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2119	370	None	37	Human	Functional	pAC50	=	8.2	8.2	-3	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	563	370	None	37	Human	Functional	pAC50	=	8.2	8.2	-3	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	66368	370	None	37	Human	Functional	pAC50	=	8.2	8.2	-3	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL266195	370	None	37	Human	Functional	pAC50	=	8.2	8.2	-3	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00866	370	None	37	Human	Functional	pAC50	=	8.2	8.2	-3	8	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	4631	197216	None	23	Human	Functional	pAC50	=	8.2	8.2	-1	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	265	9	2	4	2.0	C=CCOc1ccccc1OCC(O)CNC(C)C	10.1038/s41467-023-40064-9
	4631.0	197216	None	23	Human	Functional	pAC50	=	8.2	8.2	-1	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	265	9	2	4	2.0	C=CCOc1ccccc1OCC(O)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL546	197216	None	23	Human	Functional	pAC50	=	8.2	8.2	-1	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	265	9	2	4	2.0	C=CCOc1ccccc1OCC(O)CNC(C)C	10.1038/s41467-023-40064-9
	DB01580	197216	None	23	Human	Functional	pAC50	=	8.2	8.2	-1	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	265	9	2	4	2.0	C=CCOc1ccccc1OCC(O)CNC(C)C	10.1038/s41467-023-40064-9
	2169	44861	None	29	Human	Functional	pAC50	=	7.2	7.2	1	12	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44861	None	29	Human	Functional	pAC50	=	7.2	7.2	1	12	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	1155	1629	None	38	Human	Functional	pAC50	=	5.2	5.2	-7	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	3343	1629	None	38	Human	Functional	pAC50	=	5.2	5.2	-7	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	557	1629	None	38	Human	Functional	pAC50	=	5.2	5.2	-7	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL32800	1629	None	38	Human	Functional	pAC50	=	5.2	5.2	-7	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	DB01288	1629	None	38	Human	Functional	pAC50	=	5.2	5.2	-7	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	5329102	194838	None	50	Human	Functional	pAC50	=	5.2	5.2	-54	37	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194838	None	50	Human	Functional	pAC50	=	5.2	5.2	-54	37	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	2249	512	None	65	Human	Functional	pAC50	=	6.2	6.2	-38	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	2249.0	512	None	65	Human	Functional	pAC50	=	6.2	6.2	-38	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	255	512	None	65	Human	Functional	pAC50	=	6.2	6.2	-38	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	548	512	None	65	Human	Functional	pAC50	=	6.2	6.2	-38	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL24	512	None	65	Human	Functional	pAC50	=	6.2	6.2	-38	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	DB00335	512	None	65	Human	Functional	pAC50	=	6.2	6.2	-38	5	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	9801	91619	None	25	Human	Functional	pAC50	=	5.2	5.2	-17	16	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL24072	91619	None	25	Human	Functional	pAC50	=	5.2	5.2	-17	16	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135409453	3773	None	26	Human	Functional	pAC50	=	5.2	5.2	-2398	35	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	None	26	Human	Functional	pAC50	=	5.2	5.2	-2398	35	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	None	26	Human	Functional	pAC50	=	5.2	5.2	-2398	35	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	242	470	None	70	Human	Functional	pAC50	=	6.1	6.1	-213	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	70	Human	Functional	pAC50	=	6.1	6.1	-213	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	70	Human	Functional	pAC50	=	6.1	6.1	-213	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795.0	470	None	70	Human	Functional	pAC50	=	6.1	6.1	-213	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	70	Human	Functional	pAC50	=	6.1	6.1	-213	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	70	Human	Functional	pAC50	=	6.1	6.1	-213	33	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	2663	98816	None	20	Human	Functional	pAC50	=	7.1	7.1	60	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	379	9	3	5	2.9	CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1	10.1038/s41467-023-40064-9
	2663.0	98816	None	20	Human	Functional	pAC50	=	7.1	7.1	60	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	379	9	3	5	2.9	CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL27810	98816	None	20	Human	Functional	pAC50	=	7.1	7.1	60	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	379	9	3	5	2.9	CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1	10.1038/s41467-023-40064-9
	DB04846	98816	None	20	Human	Functional	pAC50	=	7.1	7.1	60	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	379	9	3	5	2.9	CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1	10.1038/s41467-023-40064-9
	2335	11852	None	18	Human	Functional	pAC50	=	5.1	5.1	-57	34	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11852	None	18	Human	Functional	pAC50	=	5.1	5.1	-57	34	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11852	None	18	Human	Functional	pAC50	=	5.1	5.1	-57	34	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11852	None	18	Human	Functional	pAC50	=	5.1	5.1	-57	34	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	56959	31564	None	60	Human	Functional	pAC50	=	5.1	5.1	-5	9	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	31564	None	60	Human	Functional	pAC50	=	5.1	5.1	-5	9	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	31564	None	60	Human	Functional	pAC50	=	5.1	5.1	-5	9	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	5639	98949	None	48	Human	Functional	pAC50	=	6.1	6.1	-15	13	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL279229	98949	None	48	Human	Functional	pAC50	=	6.1	6.1	-15	13	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	2351	4301	None	35	Human	Functional	pAC50	=	5.1	5.1	-3	22	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4301	None	35	Human	Functional	pAC50	=	5.1	5.1	-3	22	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4301	None	35	Human	Functional	pAC50	=	5.1	5.1	-3	22	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	11658860	2344	None	24	Human	Functional	pAC50	=	5.1	5.1	-724	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2344	None	24	Human	Functional	pAC50	=	5.1	5.1	-724	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2344	None	24	Human	Functional	pAC50	=	5.1	5.1	-724	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2344	None	24	Human	Functional	pAC50	=	5.1	5.1	-724	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2344	None	24	Human	Functional	pAC50	=	5.1	5.1	-724	11	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	119607	208661	None	64	Human	Functional	pAC50	=	5.1	5.1	1	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL865	208661	None	64	Human	Functional	pAC50	=	5.1	5.1	1	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	10.1038/s41467-023-40064-9
	68617	207985	None	33	Human	Functional	pAC50	=	5.1	5.1	-23	30	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	207985	None	33	Human	Functional	pAC50	=	5.1	5.1	-23	30	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	207985	None	33	Human	Functional	pAC50	=	5.1	5.1	-23	30	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	16363	596	None	33	Human	Functional	pAC50	=	5.1	5.1	-1621	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	16363.0	596	None	33	Human	Functional	pAC50	=	5.1	5.1	-1621	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	None	33	Human	Functional	pAC50	=	5.1	5.1	-1621	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	None	33	Human	Functional	pAC50	=	5.1	5.1	-1621	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	None	33	Human	Functional	pAC50	=	5.1	5.1	-1621	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	None	33	Human	Functional	pAC50	=	5.1	5.1	-1621	21	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	1054	1586	None	40	Human	Functional	pAC50	=	6.1	6.1	66	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	295	9	2	5	1.5	COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	59768	1586	None	40	Human	Functional	pAC50	=	6.1	6.1	66	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	295	9	2	5	1.5	COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	7178	1586	None	40	Human	Functional	pAC50	=	6.1	6.1	66	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	295	9	2	5	1.5	COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL768	1586	None	40	Human	Functional	pAC50	=	6.1	6.1	66	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	295	9	2	5	1.5	COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00187	1586	None	40	Human	Functional	pAC50	=	6.1	6.1	66	2	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	295	9	2	5	1.5	COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	275196	125740	None	38	Human	Functional	pAC50	=	5.1	5.1	-69	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
	CHEMBL2106732	125740	None	38	Human	Functional	pAC50	=	5.1	5.1	-69	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
	CHEMBL364713	125740	None	38	Human	Functional	pAC50	=	5.1	5.1	-69	6	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
	156419	938	None	48	Human	Functional	pAC50	=	5.1	5.1	-204	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	156419.0	938	None	48	Human	Functional	pAC50	=	5.1	5.1	-204	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	3308	938	None	48	Human	Functional	pAC50	=	5.1	5.1	-204	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	647	938	None	48	Human	Functional	pAC50	=	5.1	5.1	-204	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL1201284	938	None	48	Human	Functional	pAC50	=	5.1	5.1	-204	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB01012	938	None	48	Human	Functional	pAC50	=	5.1	5.1	-204	20	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	41684	31229	None	62	Human	Functional	pAC50	=	5.1	5.1	-19	32	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31229	None	62	Human	Functional	pAC50	=	5.1	5.1	-19	32	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	1673	962	None	12	Human	Functional	pAC50	=	6.1	6.1	-1	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	5284371	962	None	12	Human	Functional	pAC50	=	6.1	6.1	-1	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	5284371.0	962	None	12	Human	Functional	pAC50	=	6.1	6.1	-1	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	725	962	None	12	Human	Functional	pAC50	=	6.1	6.1	-1	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	CHEMBL485	962	None	12	Human	Functional	pAC50	=	6.1	6.1	-1	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	DB00318	962	None	12	Human	Functional	pAC50	=	6.1	6.1	-1	3	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Functional	pAC50	=	5.0	5.0	-1659	29	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Functional	pAC50	=	5.0	5.0	-1659	29	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Functional	pAC50	=	5.0	5.0	-1659	29	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Functional	pAC50	=	5.0	5.0	-1659	29	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Functional	pAC50	=	5.0	5.0	-1659	29	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Functional	pAC50	=	5.0	5.0	-1659	29	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	135564886	14499	None	5	Human	Functional	pAC50	=	5.0	5.0	-3	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	135673376	14499	None	5	Human	Functional	pAC50	=	5.0	5.0	-3	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	137157436	14499	None	5	Human	Functional	pAC50	=	5.0	5.0	-3	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	145948239	14499	None	5	Human	Functional	pAC50	=	5.0	5.0	-3	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	71587099	14499	None	5	Human	Functional	pAC50	=	5.0	5.0	-3	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1201304	14499	None	5	Human	Functional	pAC50	=	5.0	5.0	-3	25	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	1028	291	None	40	Human	Functional	pAC50	=	6.0	6.0	-10	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	291	None	40	Human	Functional	pAC50	=	6.0	6.0	-10	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	291	None	40	Human	Functional	pAC50	=	6.0	6.0	-10	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	291	None	40	Human	Functional	pAC50	=	6.0	6.0	-10	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816.0	291	None	40	Human	Functional	pAC50	=	6.0	6.0	-10	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	291	None	40	Human	Functional	pAC50	=	6.0	6.0	-10	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	291	None	40	Human	Functional	pAC50	=	6.0	6.0	-10	19	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	2405	665	None	48	Human	Functional	pAC50	=	7	7.0	-6	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	2405.0	665	None	48	Human	Functional	pAC50	=	7	7.0	-6	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	380	665	None	48	Human	Functional	pAC50	=	7	7.0	-6	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	7129	665	None	48	Human	Functional	pAC50	=	7	7.0	-6	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL645	665	None	48	Human	Functional	pAC50	=	7	7.0	-6	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	DB00612	665	None	48	Human	Functional	pAC50	=	7	7.0	-6	4	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	9849126	12443	None	0	Guinea pig	Functional	pEC50	=	10.4	10.4	3	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	CHEMBL1185969	12443	None	0	Guinea pig	Functional	pEC50	=	10.4	10.4	3	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	CHEMBL443435	12443	None	0	Guinea pig	Functional	pEC50	=	10.4	10.4	3	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	1499	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	3779	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	3779.0	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	536	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	DB01064	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	1499	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	3779	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	3779.0	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	536	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	DB01064	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	1499	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	3779	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	3779.0	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	536	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	DB01064	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	1499	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	3779	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	3779.0	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	536	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	DB01064	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	1499	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	3779	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	3779.0	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	536	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	DB01064	2091	None	34	Human	Functional	pEC50	=	10.1	10.1	-58	38	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	11268355	96449	None	0	Human	Functional	pEC50	=	9.9	9.9	1	3	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	358	7	3	3	4.1	COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12	10.1016/s0960-894x(03)00073-8
	CHEMBL26183	96449	None	0	Human	Functional	pEC50	=	9.9	9.9	1	3	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	358	7	3	3	4.1	COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12	10.1016/s0960-894x(03)00073-8
	1239	1677	None	37	Guinea pig	Functional	pEC50	=	9.5	9.5	1	6	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	3410	1677	None	37	Guinea pig	Functional	pEC50	=	9.5	9.5	1	6	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	3410.0	1677	None	37	Guinea pig	Functional	pEC50	=	9.5	9.5	1	6	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	3465	1677	None	37	Guinea pig	Functional	pEC50	=	9.5	9.5	1	6	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	CHEMBL1256786	1677	None	37	Guinea pig	Functional	pEC50	=	9.5	9.5	1	6	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	DB00983	1677	None	37	Guinea pig	Functional	pEC50	=	9.5	9.5	1	6	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	24936881	17524	None	0	Human	Functional	pEC50	=	9.2	9.2	1	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	476	8	3	8	4.1	Oc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1	10.1016/j.bmcl.2010.08.039
	CHEMBL1257913	17524	None	0	Human	Functional	pEC50	=	9.2	9.2	1	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	476	8	3	8	4.1	Oc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1	10.1016/j.bmcl.2010.08.039
	12065	628	None	28	Human	Functional	pEC50	=	9.2	9.2	-6	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	45483813	628	None	28	Human	Functional	pEC50	=	9.2	9.2	-6	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	CHEMBL579394	628	None	28	Human	Functional	pEC50	=	9.2	9.2	-6	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	164622827	188671	None	0	Human	Functional	pEC50	=	9.2	9.2	-26	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868585	188671	None	0	Human	Functional	pEC50	=	9.2	9.2	-26	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028721	188671	None	0	Human	Functional	pEC50	=	9.2	9.2	-26	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	9891927	184303	None	9	Guinea pig	Functional	pEC50	=	9.1	9.1	-5	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL446840	184303	None	9	Guinea pig	Functional	pEC50	=	9.1	9.1	-5	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483200	184303	None	9	Guinea pig	Functional	pEC50	=	9.1	9.1	-5	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483201	184303	None	9	Guinea pig	Functional	pEC50	=	9.1	9.1	-5	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	45483810	199600	None	0	Human	Functional	pEC50	=	9.1	9.1	-3	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	356	6	4	5	2.4	CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL567863	199600	None	0	Human	Functional	pEC50	=	9.1	9.1	-3	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	356	6	4	5	2.4	CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	123686	1981	None	38	Human	Functional	pEC50	=	9.1	9.1	74	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	354	9	4	5	1.7	C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O	10.1021/jm400348g
	12581	1981	None	38	Human	Functional	pEC50	=	9.1	9.1	74	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	354	9	4	5	1.7	C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O	10.1021/jm400348g
	CHEMBL11268	1981	None	38	Human	Functional	pEC50	=	9.1	9.1	74	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	354	9	4	5	1.7	C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O	10.1021/jm400348g
	1499	2091	None	34	Human	Functional	pEC50	=	9.1	9.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	3779	2091	None	34	Human	Functional	pEC50	=	9.1	9.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	3779.0	2091	None	34	Human	Functional	pEC50	=	9.1	9.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	536	2091	None	34	Human	Functional	pEC50	=	9.1	9.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	9.1	9.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	DB01064	2091	None	34	Human	Functional	pEC50	=	9.1	9.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	164623105	188675	None	0	Human	Functional	pEC50	=	9.1	9.1	-47	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4862449	188675	None	0	Human	Functional	pEC50	=	9.1	9.1	-47	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028738	188675	None	0	Human	Functional	pEC50	=	9.1	9.1	-47	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	13345218	199677	None	0	Human	Functional	pEC50	=	9.1	9.1	-8	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	372	6	5	6	2.1	CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL568272	199677	None	0	Human	Functional	pEC50	=	9.1	9.1	-8	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	372	6	5	6	2.1	CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	44392175	131862	None	0	Human	Functional	pEC50	=	9.1	9.1	1	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	480	12	5	7	3.2	O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc([N+](=O)[O-])c1	10.1016/j.bmcl.2004.11.001
	CHEMBL369346	131862	None	0	Human	Functional	pEC50	=	9.1	9.1	1	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	480	12	5	7	3.2	O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc([N+](=O)[O-])c1	10.1016/j.bmcl.2004.11.001
	1499	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	3779	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	3779.0	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	536	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	DB01064	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	1499	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	3779	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	3779.0	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	536	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	DB01064	2091	None	34	Human	Functional	pEC50	=	9	9.0	-58	38	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	1499	2091	None	34	Human	Functional	pEC50	=	8.9	8.9	-58	38	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	3779	2091	None	34	Human	Functional	pEC50	=	8.9	8.9	-58	38	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.9	8.9	-58	38	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	536	2091	None	34	Human	Functional	pEC50	=	8.9	8.9	-58	38	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.9	8.9	-58	38	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.9	8.9	-58	38	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	44392230	65618	None	1	Human	Functional	pEC50	=	8.9	8.9	1	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	479	12	6	6	3.0	O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc(C(=O)O)c1	10.1016/j.bmcl.2004.11.001
	CHEMBL183283	65618	None	1	Human	Functional	pEC50	=	8.9	8.9	1	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	479	12	6	6	3.0	O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc(C(=O)O)c1	10.1016/j.bmcl.2004.11.001
	24822304	97917	None	0	Human	Functional	pEC50	=	8.9	8.9	6	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	412	9	3	5	4.1	O=C(O)c1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1	10.1021/jm701324c
	CHEMBL272234	97917	None	0	Human	Functional	pEC50	=	8.9	8.9	6	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	412	9	3	5	4.1	O=C(O)c1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1	10.1021/jm701324c
	105	3461	None	54	Human	Functional	pEC50	=	8.8	8.8	-28	3	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	2083	3461	None	54	Human	Functional	pEC50	=	8.8	8.8	-28	3	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	2083.0	3461	None	54	Human	Functional	pEC50	=	8.8	8.8	-28	3	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	558	3461	None	54	Human	Functional	pEC50	=	8.8	8.8	-28	3	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	CHEMBL714	3461	None	54	Human	Functional	pEC50	=	8.8	8.8	-28	3	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	DB01001	3461	None	54	Human	Functional	pEC50	=	8.8	8.8	-28	3	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	164615126	188611	None	0	Human	Functional	pEC50	=	8.8	8.8	-104	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4854569	188611	None	0	Human	Functional	pEC50	=	8.8	8.8	-104	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028293	188611	None	0	Human	Functional	pEC50	=	8.8	8.8	-104	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	90645347	112576	None	0	Human	Functional	pEC50	=	8.8	8.8	-7	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	12	6	7	5.6	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298987	112576	None	0	Human	Functional	pEC50	=	8.8	8.8	-7	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	12	6	7	5.6	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	164618895	188642	None	0	Human	Functional	pEC50	=	8.8	8.8	-95	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868938	188642	None	0	Human	Functional	pEC50	=	8.8	8.8	-95	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028525	188642	None	0	Human	Functional	pEC50	=	8.8	8.8	-95	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	45101519	200979	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	498	11	8	7	1.6	CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL577917	200979	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	498	11	8	7	1.6	CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	24936492	17556	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	482	8	3	9	4.1	Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5cccs5)c34)CC2)cc1	10.1016/j.bmcl.2010.08.039
	CHEMBL1258026	17556	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	482	8	3	9	4.1	Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5cccs5)c34)CC2)cc1	10.1016/j.bmcl.2010.08.039
	164612078	188585	None	0	Human	Functional	pEC50	=	8.7	8.7	-64	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848617	188585	None	0	Human	Functional	pEC50	=	8.7	8.7	-64	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028119	188585	None	0	Human	Functional	pEC50	=	8.7	8.7	-64	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	9927453	96740	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	3	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	328	6	3	2	4.1	C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	CHEMBL26393	96740	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	3	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	328	6	3	2	4.1	C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	42625513	12563	None	0	Guinea pig	Functional	pEC50	=	8.7	8.7	-3	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm801016j
	CHEMBL1186722	12563	None	0	Guinea pig	Functional	pEC50	=	8.7	8.7	-3	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm801016j
	CHEMBL475389	12563	None	0	Guinea pig	Functional	pEC50	=	8.7	8.7	-3	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm801016j
	90645346	112558	None	0	Human	Functional	pEC50	=	8.7	8.7	-2	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	13	6	7	4.7	O=C(NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298762	112558	None	0	Human	Functional	pEC50	=	8.7	8.7	-2	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	13	6	7	4.7	O=C(NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2014.04.095
	42625517	12725	None	0	Guinea pig	Functional	pEC50	=	8	8.0	-19	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1187654	12725	None	0	Guinea pig	Functional	pEC50	=	8	8.0	-19	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL514032	12725	None	0	Guinea pig	Functional	pEC50	=	8	8.0	-19	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	11180293	112571	None	0	Human	Functional	pEC50	=	8	8.0	-22	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	543	12	6	8	3.1	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298897	112571	None	0	Human	Functional	pEC50	=	8	8.0	-22	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	543	12	6	8	3.1	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	56668796	66623	None	0	Human	Functional	pEC50	=	8	8.0	-31	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	598	20	7	7	4.3	O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1	10.1016/j.bmc.2011.08.043
	CHEMBL1835860	66623	None	0	Human	Functional	pEC50	=	8	8.0	-31	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	598	20	7	7	4.3	O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1	10.1016/j.bmc.2011.08.043
	CHEMBL1852632	66623	None	0	Human	Functional	pEC50	=	8	8.0	-31	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	598	20	7	7	4.3	O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1	10.1016/j.bmc.2011.08.043
	45273268	198085	None	0	Human	Functional	pEC50	=	8	8.0	194	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	362	10	3	4	4.0	O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204004	198085	None	0	Human	Functional	pEC50	=	8	8.0	194	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	362	10	3	4	4.0	O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL556274	198085	None	0	Human	Functional	pEC50	=	8	8.0	194	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	362	10	3	4	4.0	O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	10217757	112333	None	0	Human	Functional	pEC50	=	8	8.0	-31	4	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	497	12	5	6	5.2	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	CHEMBL3290998	112333	None	0	Human	Functional	pEC50	=	8	8.0	-31	4	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	497	12	5	6	5.2	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	164614147	188599	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4856990	188599	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028233	188599	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164618813	188641	None	0	Human	Functional	pEC50	=	8.0	8.0	-275	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4865833	188641	None	0	Human	Functional	pEC50	=	8.0	8.0	-275	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028523	188641	None	0	Human	Functional	pEC50	=	8.0	8.0	-275	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	164619360	188645	None	0	Human	Functional	pEC50	=	8.0	8.0	-371	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868763	188645	None	0	Human	Functional	pEC50	=	8.0	8.0	-371	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028547	188645	None	0	Human	Functional	pEC50	=	8.0	8.0	-371	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	1155	1629	None	38	Human	Functional	pEC50	=	8.0	8.0	-7	11	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1016/j.ejmech.2022.114961
	3343	1629	None	38	Human	Functional	pEC50	=	8.0	8.0	-7	11	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1016/j.ejmech.2022.114961
	557	1629	None	38	Human	Functional	pEC50	=	8.0	8.0	-7	11	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1016/j.ejmech.2022.114961
	CHEMBL32800	1629	None	38	Human	Functional	pEC50	=	8.0	8.0	-7	11	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1016/j.ejmech.2022.114961
	DB01288	1629	None	38	Human	Functional	pEC50	=	8.0	8.0	-7	11	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1016/j.ejmech.2022.114961
	155774	4096	None	34	Human	Functional	pEC50	=	8.0	8.0	38	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	2848	4096	None	34	Human	Functional	pEC50	=	8.0	8.0	38	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	538	4096	None	34	Human	Functional	pEC50	=	8.0	8.0	38	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	CHEMBL75753	4096	None	34	Human	Functional	pEC50	=	8.0	8.0	38	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	DB13781	4096	None	34	Human	Functional	pEC50	=	8.0	8.0	38	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	10863093	50341	None	0	Human	Functional	pEC50	=	7	7.0	-19	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	439	10	4	6	2.1	C[C@H](CNc1ccc(CC(=O)NS(C)(=O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL157210	50341	None	0	Human	Functional	pEC50	=	7	7.0	-19	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	439	10	4	6	2.1	C[C@H](CNc1ccc(CC(=O)NS(C)(=O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	16049450	64114	None	0	Human	Functional	pEC50	=	7	7.0	-125	2	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807827	64114	None	0	Human	Functional	pEC50	=	7	7.0	-125	2	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	16049234	64115	None	0	Human	Functional	pEC50	=	7	7.0	-177	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3ccccc3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807828	64115	None	0	Human	Functional	pEC50	=	7	7.0	-177	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3ccccc3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	16049448	64116	None	0	Human	Functional	pEC50	=	7	7.0	-56	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	515	13	5	7	4.2	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807829	64116	None	0	Human	Functional	pEC50	=	7	7.0	-56	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	515	13	5	7	4.2	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	16049374	64120	None	0	Human	Functional	pEC50	=	7	7.0	-89	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807869	64120	None	0	Human	Functional	pEC50	=	7	7.0	-89	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	1499	2091	None	34	Human	Functional	pEC50	=	7	7.0	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	3779	2091	None	34	Human	Functional	pEC50	=	7	7.0	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	3779.0	2091	None	34	Human	Functional	pEC50	=	7	7.0	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	536	2091	None	34	Human	Functional	pEC50	=	7	7.0	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	7	7.0	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	DB01064	2091	None	34	Human	Functional	pEC50	=	7	7.0	-58	38	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	9888047	93434	None	0	Human	Functional	pEC50	=	7	7.0	-398	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	414	9	4	5	4.4	C[C@H](CNc1cccc(-c2occc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL245673	93434	None	0	Human	Functional	pEC50	=	7	7.0	-398	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	414	9	4	5	4.4	C[C@H](CNc1cccc(-c2occc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	44441231	148142	None	0	Human	Functional	pEC50	=	7	7.0	-50	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	431	9	4	6	4.3	C[C@H](CNc1cccc(-c2csc(C(=O)O)n2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL393470	148142	None	0	Human	Functional	pEC50	=	7	7.0	-50	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	431	9	4	6	4.3	C[C@H](CNc1cccc(-c2csc(C(=O)O)n2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	44441235	151081	None	0	Human	Functional	pEC50	=	7	7.0	-251	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	430	9	4	5	4.9	C[C@H](CNc1ccc(-c2sccc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL395834	151081	None	0	Human	Functional	pEC50	=	7	7.0	-251	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	430	9	4	5	4.9	C[C@H](CNc1ccc(-c2sccc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	45271523	197584	None	0	Human	Functional	pEC50	=	7	7.0	-10	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	435	10	4	4	4.4	Cc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204000	197584	None	0	Human	Functional	pEC50	=	7	7.0	-10	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	435	10	4	4	4.4	Cc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL550096	197584	None	0	Human	Functional	pEC50	=	7	7.0	-10	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	435	10	4	4	4.4	Cc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	45272417	197897	None	0	Human	Functional	pEC50	=	7	7.0	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2cccc(Cl)c2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL2448074	197897	None	0	Human	Functional	pEC50	=	7	7.0	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2cccc(Cl)c2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL552368	197897	None	0	Human	Functional	pEC50	=	7	7.0	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2cccc(Cl)c2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	42625823	12683	None	0	Human	Functional	pEC50	=	7	7.0	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1187371	12683	None	0	Human	Functional	pEC50	=	7	7.0	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL500782	12683	None	0	Human	Functional	pEC50	=	7	7.0	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	46832804	6988	None	0	Human	Functional	pEC50	=	7	7.0	-50	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	496	17	5	8	1.9	NS(=O)(=O)c1ccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm100326d
	CHEMBL1084655	6988	None	0	Human	Functional	pEC50	=	7	7.0	-50	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	496	17	5	8	1.9	NS(=O)(=O)c1ccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm100326d
	10553603	99752	None	0	Human	Functional	pEC50	=	7	7.0	1	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	506	10	6	8	1.5	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(NC(=O)CC(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	CHEMBL284612	99752	None	0	Human	Functional	pEC50	=	7	7.0	1	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	506	10	6	8	1.5	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(NC(=O)CC(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	42625517	12725	None	0	Human	Functional	pEC50	=	6	6.0	-1995	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1187654	12725	None	0	Human	Functional	pEC50	=	6	6.0	-1995	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL514032	12725	None	0	Human	Functional	pEC50	=	6	6.0	-1995	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	42625588	180532	None	0	Human	Functional	pEC50	=	6	6.0	-630	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	508	18	5	7	2.9	NS(=O)(=O)Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL475237	180532	None	0	Human	Functional	pEC50	=	6	6.0	-630	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	508	18	5	7	2.9	NS(=O)(=O)Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	10121328	4439	None	0	Human	Functional	pEC50	=	6	6.0	-100	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	593	11	5	10	1.4	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4cc(C(=O)O)cn4)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	CHEMBL101606	4439	None	0	Human	Functional	pEC50	=	6	6.0	-100	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	593	11	5	10	1.4	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4cc(C(=O)O)cn4)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	11575154	77244	None	0	Human	Functional	pEC50	=	5	5.0	-100000	2	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	411	9	4	5	3.8	O=C(O)c1ccncc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1	10.1021/jm0509445
	CHEMBL207943	77244	None	0	Human	Functional	pEC50	=	5	5.0	-100000	2	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	411	9	4	5	3.8	O=C(O)c1ccncc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1	10.1021/jm0509445
	44237766	58256	None	0	Rat	Functional	pEC50	=	5	5.0	-10000	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	550	10	6	6	5.5	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)Nc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682221	58256	None	0	Rat	Functional	pEC50	=	5	5.0	-10000	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	550	10	6	6	5.5	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)Nc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2010.12.096
	155517986	170310	None	0	Human	Functional	pEC50	=	5	5.0	-478630	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4445289	170310	None	0	Human	Functional	pEC50	=	5	5.0	-478630	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	164622775	188670	None	0	Human	Functional	pEC50	=	5	5.0	-120226	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL4867311	188670	None	0	Human	Functional	pEC50	=	5	5.0	-120226	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL5028718	188670	None	0	Human	Functional	pEC50	=	5	5.0	-120226	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	44313150	103832	None	0	Human	Functional	pEC50	=	5	5.0	-6	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)c2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL308868	103832	None	0	Human	Functional	pEC50	=	5	5.0	-6	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)c2)cc1	10.1016/s0960-894x(00)00459-5
	1960	2857	None	46	Guinea pig	Functional	pEC50	=	5	5.0	-37	18	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	439260	2857	None	46	Guinea pig	Functional	pEC50	=	5	5.0	-37	18	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	439260.0	2857	None	46	Guinea pig	Functional	pEC50	=	5	5.0	-37	18	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	505	2857	None	46	Guinea pig	Functional	pEC50	=	5	5.0	-37	18	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	CHEMBL1437	2857	None	46	Guinea pig	Functional	pEC50	=	5	5.0	-37	18	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	DB00368	2857	None	46	Guinea pig	Functional	pEC50	=	5	5.0	-37	18	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	10301101	103015	None	0	Human	Functional	pEC50	=	4	4.0	-1659	2	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	509	9	3	6	3.5	COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3cccc4[nH]c5ccccc5c34)CC2)cc1	10.1016/s0960-894x(03)00387-1
	CHEMBL306423	103015	None	0	Human	Functional	pEC50	=	4	4.0	-1659	2	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	509	9	3	6	3.5	COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3cccc4[nH]c5ccccc5c34)CC2)cc1	10.1016/s0960-894x(03)00387-1
	145984792	165824	None	0	Human	Functional	pEC50	=	4	4.0	-12882	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	461	12	4	5	3.1	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)c3ccccc3)cc2)c1	10.1016/j.ejmech.2018.03.032
	CHEMBL4246134	165824	None	0	Human	Functional	pEC50	=	4	4.0	-12882	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	461	12	4	5	3.1	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)c3ccccc3)cc2)c1	10.1016/j.ejmech.2018.03.032
	45483848	199596	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	394	7	3	3	5.3	CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1	10.1016/j.bmcl.2009.10.013
	CHEMBL567843	199596	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	394	7	3	3	5.3	CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1	10.1016/j.bmcl.2009.10.013
	11567751	203215	None	0	Human	Functional	pEC50	=	7	7.0	-29	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	374	6	4	5	2.5	CC(C)(Cc1ccc(F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL600401	203215	None	0	Human	Functional	pEC50	=	7	7.0	-29	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	374	6	4	5	2.5	CC(C)(Cc1ccc(F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	10145482	4170	None	0	Human	Functional	pEC50	=	6	6.0	-34	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	604	12	5	7	3.4	O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	CHEMBL100057	4170	None	0	Human	Functional	pEC50	=	6	6.0	-34	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	604	12	5	7	3.4	O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	10281165	4414	None	0	Human	Functional	pEC50	=	6.0	6.0	-16	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	560	11	5	7	3.3	O=C(Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1)NC1CCCCC1	10.1016/s0960-894x(02)00607-8
	CHEMBL101485	4414	None	0	Human	Functional	pEC50	=	6.0	6.0	-16	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	560	11	5	7	3.3	O=C(Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1)NC1CCCCC1	10.1016/s0960-894x(02)00607-8
	11539348	203243	None	0	Human	Functional	pEC50	=	7.0	7.0	-9	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	434	6	4	5	3.1	CC(C)(Cc1ccc(Br)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL600616	203243	None	0	Human	Functional	pEC50	=	7.0	7.0	-9	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	434	6	4	5	3.1	CC(C)(Cc1ccc(Br)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	44309649	206750	None	0	Human	Functional	pEC50	=	5.0	5.0	-186	2	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	436	9	3	7	1.6	COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(03)00387-1
	CHEMBL71348	206750	None	0	Human	Functional	pEC50	=	5.0	5.0	-186	2	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	436	9	3	7	1.6	COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(03)00387-1
	3083544	26817	None	34	Human	Functional	pEC50	=	7.0	7.0	-199	6	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/acs.jmedchem.0c01195
	3083544.0	26817	None	34	Human	Functional	pEC50	=	7.0	7.0	-199	6	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/acs.jmedchem.0c01195
	CHEMBL1200811	26817	None	34	Human	Functional	pEC50	=	7.0	7.0	-199	6	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/acs.jmedchem.0c01195
	CHEMBL1363	26817	None	34	Human	Functional	pEC50	=	7.0	7.0	-199	6	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/acs.jmedchem.0c01195
	CHEMBL1951071	26817	None	34	Human	Functional	pEC50	=	7.0	7.0	-199	6	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/acs.jmedchem.0c01195
	CHEMBL605993	26817	None	34	Human	Functional	pEC50	=	7.0	7.0	-199	6	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/acs.jmedchem.0c01195
	DB00983	26817	None	34	Human	Functional	pEC50	=	7.0	7.0	-199	6	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/acs.jmedchem.0c01195
	DB01274	26817	None	34	Human	Functional	pEC50	=	7.0	7.0	-199	6	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/acs.jmedchem.0c01195
	10280301	109793	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	536	12	5	6	3.9	O=C(NCc1ccc(F)cc1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL322973	109793	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	536	12	5	6	3.9	O=C(NCc1ccc(F)cc1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	10231394	167919	None	0	Human	Functional	pEC50	=	5.0	5.0	-190	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	562	15	5	7	3.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	CHEMBL430662	167919	None	0	Human	Functional	pEC50	=	5.0	5.0	-190	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	562	15	5	7	3.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	24823782	98098	None	0	Human	Functional	pEC50	=	8.0	8.0	3	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	396	8	3	4	4.0	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1	10.1021/jm701324c
	CHEMBL273097	98098	None	0	Human	Functional	pEC50	=	8.0	8.0	3	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	396	8	3	4	4.0	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1	10.1021/jm701324c
	45484646	199750	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	456	10	6	7	2.0	CC(C)(Cc1ccc(NC(=O)CCCN)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL568667	199750	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	456	10	6	7	2.0	CC(C)(Cc1ccc(NC(=O)CCCN)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	24894323	176563	None	0	Human	Functional	pEC50	=	8.0	8.0	-52	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	468	12	4	5	5.2	CCCOc1cc(-c2ccc(NCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL459645	176563	None	0	Human	Functional	pEC50	=	8.0	8.0	-52	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	468	12	4	5	5.2	CCCOc1cc(-c2ccc(NCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	155536813	172309	None	0	Human	Functional	pEC50	=	8.0	8.0	-263	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4473790	172309	None	0	Human	Functional	pEC50	=	8.0	8.0	-263	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	45270680	197285	None	0	Human	Functional	pEC50	=	7.0	7.0	5	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	421	10	4	4	4.1	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203993	197285	None	0	Human	Functional	pEC50	=	7.0	7.0	5	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	421	10	4	4	4.1	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL549421	197285	None	0	Human	Functional	pEC50	=	7.0	7.0	5	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	421	10	4	4	4.1	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	45269853	199024	None	0	Human	Functional	pEC50	=	7.0	7.0	-4	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	426	11	3	5	3.1	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL563872	199024	None	0	Human	Functional	pEC50	=	7.0	7.0	-4	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	426	11	3	5	3.1	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	52943968	17801	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	518	9	4	8	3.8	NC(=O)Nc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1	10.1016/j.bmcl.2010.08.039
	CHEMBL1258824	17801	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	518	9	4	8	3.8	NC(=O)Nc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1	10.1016/j.bmcl.2010.08.039
	16222840	198187	None	0	Human	Functional	pEC50	=	7.0	7.0	-316	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	ChEMBL	566	11	4	7	4.7	C[C@H](NCCc1ccc(-c2ccc(C(=O)NS(C)(=O)=O)c(OC3CCCCC3)c2)cc1)[C@H](O)c1ccc(O)cc1	10.1016/j.bmcl.2009.06.083
	CHEMBL557253	198187	None	0	Human	Functional	pEC50	=	7.0	7.0	-316	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	ChEMBL	566	11	4	7	4.7	C[C@H](NCCc1ccc(-c2ccc(C(=O)NS(C)(=O)=O)c(OC3CCCCC3)c2)cc1)[C@H](O)c1ccc(O)cc1	10.1016/j.bmcl.2009.06.083
	24895559	173204	None	0	Human	Functional	pEC50	=	7.0	7.0	-338	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	483	12	3	5	5.4	CC(C)COc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL452034	173204	None	0	Human	Functional	pEC50	=	7.0	7.0	-338	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	483	12	3	5	5.4	CC(C)COc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	105	3461	None	54	Human	Functional	pEC50	=	5.9	5.9	-28	3	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.0c01195
	2083	3461	None	54	Human	Functional	pEC50	=	5.9	5.9	-28	3	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.0c01195
	2083.0	3461	None	54	Human	Functional	pEC50	=	5.9	5.9	-28	3	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.0c01195
	558	3461	None	54	Human	Functional	pEC50	=	5.9	5.9	-28	3	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.0c01195
	CHEMBL714	3461	None	54	Human	Functional	pEC50	=	5.9	5.9	-28	3	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.0c01195
	DB01001	3461	None	54	Human	Functional	pEC50	=	5.9	5.9	-28	3	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.0c01195
	44377726	56834	None	0	Human	Functional	pEC50	=	5.9	5.9	-389	2	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	550	10	5	10	1.6	CS(=O)(=O)Nc1cc(O[C@@H](O)CNC2CCN(c3ccc(CC4SC(=O)NC4=O)cc3)CC2)ccc1O	10.1016/s0960-894x(01)00063-4
	CHEMBL164378	56834	None	0	Human	Functional	pEC50	=	5.9	5.9	-389	2	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	550	10	5	10	1.6	CS(=O)(=O)Nc1cc(O[C@@H](O)CNC2CCN(c3ccc(CC4SC(=O)NC4=O)cc3)CC2)ccc1O	10.1016/s0960-894x(01)00063-4
	1499	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.06.031
	3779	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.06.031
	3779.0	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.06.031
	536	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.06.031
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.06.031
	DB01064	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.06.031
	1499	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2009.01.022
	3779	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2009.01.022
	3779.0	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2009.01.022
	536	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2009.01.022
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2009.01.022
	DB01064	2091	None	34	Human	Functional	pEC50	=	7.9	7.9	-58	38	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2009.01.022
	16223251	176564	None	0	Human	Functional	pEC50	=	7.9	7.9	-204	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	449	11	4	6	3.9	CC(C)Cc1cc(-c2ccc(OCCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL459646	176564	None	0	Human	Functional	pEC50	=	7.9	7.9	-204	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	449	11	4	6	3.9	CC(C)Cc1cc(-c2ccc(OCCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	24895787	186800	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	409	8	3	3	5.0	C[C@@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm8000345
	CHEMBL488431	186800	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	409	8	3	3	5.0	C[C@@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm8000345
	44309272	206336	None	0	Human	Functional	pEC50	=	7.9	7.9	-2	3	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	611	14	6	8	2.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1	10.1016/s0960-894x(03)00387-1
	CHEMBL68766	206336	None	0	Human	Functional	pEC50	=	7.9	7.9	-2	3	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	611	14	6	8	2.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1	10.1016/s0960-894x(03)00387-1
	44392181	66092	None	0	Human	Functional	pEC50	=	7.9	7.9	-10	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	465	12	5	6	3.3	COc1ccccc1NC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	CHEMBL183744	66092	None	0	Human	Functional	pEC50	=	7.9	7.9	-10	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	465	12	5	6	3.3	COc1ccccc1NC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	44441230	93840	None	0	Human	Functional	pEC50	=	7.9	7.9	-7	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	431	9	4	6	4.3	C[C@H](CNc1ccc(-c2csc(C(=O)O)n2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL247518	93840	None	0	Human	Functional	pEC50	=	7.9	7.9	-7	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	431	9	4	6	4.3	C[C@H](CNc1ccc(-c2csc(C(=O)O)n2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	2687	889	None	12	Human	Functional	pEC50	=	7.9	7.9	-6	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	279	5	4	4	1.0	OC(COc1cccc2c1[nH]c(=O)[nH]2)CNC(C)(C)C	10.1021/jm400348g
	532	889	None	12	Human	Functional	pEC50	=	7.9	7.9	-6	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	279	5	4	4	1.0	OC(COc1cccc2c1[nH]c(=O)[nH]2)CNC(C)(C)C	10.1021/jm400348g
	5387	889	None	12	Human	Functional	pEC50	=	7.9	7.9	-6	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	279	5	4	4	1.0	OC(COc1cccc2c1[nH]c(=O)[nH]2)CNC(C)(C)C	10.1021/jm400348g
	CHEMBL420746	889	None	12	Human	Functional	pEC50	=	7.9	7.9	-6	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	279	5	4	4	1.0	OC(COc1cccc2c1[nH]c(=O)[nH]2)CNC(C)(C)C	10.1021/jm400348g
	44441226	93721	None	0	Human	Functional	pEC50	=	7.9	7.9	1	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	9	4	6	3.8	C[C@H](CNc1ccc(-c2nc(C(=O)O)co2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL246908	93721	None	0	Human	Functional	pEC50	=	7.9	7.9	1	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	9	4	6	3.8	C[C@H](CNc1ccc(-c2nc(C(=O)O)co2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	1239	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	3410	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	3410.0	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	3465	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	CHEMBL1256786	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	DB00983	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	90645345	112542	None	0	Human	Functional	pEC50	=	7.9	7.9	-11	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	574	12	6	8	4.7	CC(C)(C)OC(=O)NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298692	112542	None	0	Human	Functional	pEC50	=	7.9	7.9	-11	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	574	12	6	8	4.7	CC(C)(C)OC(=O)NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	56943485	112566	None	0	Human	Functional	pEC50	=	7.9	7.9	-12	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	544	12	5	8	3.6	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCOCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298831	112566	None	0	Human	Functional	pEC50	=	7.9	7.9	-12	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	544	12	5	8	3.6	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCOCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	46832798	14208	None	0	Human	Functional	pEC50	=	7.9	7.9	-31	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	485	16	4	6	4.6	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cc(Cl)ccc2Cl)ccc1O	10.1021/jm100326d
	CHEMBL1084648	14208	None	0	Human	Functional	pEC50	=	7.9	7.9	-31	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	485	16	4	6	4.6	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cc(Cl)ccc2Cl)ccc1O	10.1021/jm100326d
	CHEMBL1198879	14208	None	0	Human	Functional	pEC50	=	7.9	7.9	-31	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	485	16	4	6	4.6	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cc(Cl)ccc2Cl)ccc1O	10.1021/jm100326d
	46832509	14217	None	0	Human	Functional	pEC50	=	7.9	7.9	-50	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	510	18	5	8	2.7	CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL1085399	14217	None	0	Human	Functional	pEC50	=	7.9	7.9	-50	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	510	18	5	8	2.7	CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL1198908	14217	None	0	Human	Functional	pEC50	=	7.9	7.9	-50	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	510	18	5	8	2.7	CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	46832232	14220	None	0	Human	Functional	pEC50	=	7.9	7.9	-100	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	467	16	4	6	4.5	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O	10.1021/jm100326d
	CHEMBL1085837	14220	None	0	Human	Functional	pEC50	=	7.9	7.9	-100	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	467	16	4	6	4.5	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O	10.1021/jm100326d
	CHEMBL1198923	14220	None	0	Human	Functional	pEC50	=	7.9	7.9	-100	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	467	16	4	6	4.5	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O	10.1021/jm100326d
	1239	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	3410	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	3410.0	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	3465	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	CHEMBL1256786	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	DB00983	1677	None	37	Human	Functional	pEC50	=	7.9	7.9	-67	6	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	24895557	173203	None	0	Human	Functional	pEC50	=	6.9	6.9	-575	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	469	12	3	5	5.2	CCCOc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL452033	173203	None	0	Human	Functional	pEC50	=	6.9	6.9	-575	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	469	12	3	5	5.2	CCCOc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	44392490	65264	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	507	10	4	6	4.0	C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NC(=O)c2ccccc2)c1	10.1016/j.bmcl.2004.12.033
	CHEMBL182708	65264	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	507	10	4	6	4.0	C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NC(=O)c2ccccc2)c1	10.1016/j.bmcl.2004.12.033
	44268327	98352	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	448	11	4	6	3.0	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C1CCCCC1	10.1016/s0960-894x(98)00169-3
	CHEMBL274807	98352	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	448	11	4	6	3.0	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C1CCCCC1	10.1016/s0960-894x(98)00169-3
	10575455	100032	None	1	Human	Functional	pEC50	=	5.9	5.9	-60	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	448	8	5	7	1.2	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(N)=O)cc3)CC2)ccc1O	10.1021/jm000544b
	CHEMBL286574	100032	None	1	Human	Functional	pEC50	=	5.9	5.9	-60	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	448	8	5	7	1.2	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(N)=O)cc3)CC2)ccc1O	10.1021/jm000544b
	11504295	2923	None	40	Human	Functional	pEC50	=	6.9	6.9	-954	8	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	11504295.0	2923	None	40	Human	Functional	pEC50	=	6.9	6.9	-954	8	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	4814	2923	None	40	Human	Functional	pEC50	=	6.9	6.9	-954	8	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	7543	2923	None	40	Human	Functional	pEC50	=	6.9	6.9	-954	8	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	CHEMBL605846	2923	None	40	Human	Functional	pEC50	=	6.9	6.9	-954	8	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	DB09080	2923	None	40	Human	Functional	pEC50	=	6.9	6.9	-954	8	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	145982668	166009	None	0	Human	Functional	pEC50	=	6.9	6.9	-15	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	418	11	3	4	4.1	CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=O)c2ccccc2)cc1	10.1016/j.ejmech.2018.03.032
	CHEMBL4250215	166009	None	0	Human	Functional	pEC50	=	6.9	6.9	-15	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	418	11	3	4	4.1	CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=O)c2ccccc2)cc1	10.1016/j.ejmech.2018.03.032
	2419	3463	None	53	Human	Functional	pEC50	=	5.9	5.9	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	5152	3463	None	53	Human	Functional	pEC50	=	5.9	5.9	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	5152.0	3463	None	53	Human	Functional	pEC50	=	5.9	5.9	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	559	3463	None	53	Human	Functional	pEC50	=	5.9	5.9	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	5.9	5.9	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	DB00938	3463	None	53	Human	Functional	pEC50	=	5.9	5.9	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	53357711	64519	None	0	Human	Functional	pEC50	=	6.9	6.9	-125	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	531	19	7	7	3.3	O=C(O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814279	64519	None	0	Human	Functional	pEC50	=	6.9	6.9	-125	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	531	19	7	7	3.3	O=C(O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814280	64519	None	0	Human	Functional	pEC50	=	6.9	6.9	-125	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	531	19	7	7	3.3	O=C(O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	56675511	66430	None	0	Human	Functional	pEC50	=	6.9	6.9	-100	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	527	18	5	7	3.2	O=C1CNC(=O)N1Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814273	66430	None	0	Human	Functional	pEC50	=	6.9	6.9	-100	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	527	18	5	7	3.2	O=C1CNC(=O)N1Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1851850	66430	None	0	Human	Functional	pEC50	=	6.9	6.9	-100	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	527	18	5	7	3.2	O=C1CNC(=O)N1Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	42625587	12704	None	0	Human	Functional	pEC50	=	6.9	6.9	-125	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	562	18	4	7	4.3	O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCCCC1	10.1021/jm801016j
	CHEMBL1187520	12704	None	0	Human	Functional	pEC50	=	6.9	6.9	-125	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	562	18	4	7	4.3	O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCCCC1	10.1021/jm801016j
	CHEMBL506518	12704	None	0	Human	Functional	pEC50	=	6.9	6.9	-125	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	562	18	4	7	4.3	O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCCCC1	10.1021/jm801016j
	9845280	77356	None	0	Human	Functional	pEC50	=	5.9	5.9	-7	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	424	9	3	5	4.5	COC(=O)c1cccc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)c1	10.1021/jm0509445
	CHEMBL208352	77356	None	0	Human	Functional	pEC50	=	5.9	5.9	-7	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	424	9	3	5	4.5	COC(=O)c1cccc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)c1	10.1021/jm0509445
	23661589	93474	None	0	Human	Functional	pEC50	=	5.9	5.9	-19952	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	430	9	4	5	4.9	C[C@H](CNc1cccc(-c2sccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL245873	93474	None	0	Human	Functional	pEC50	=	5.9	5.9	-19952	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	430	9	4	5	4.9	C[C@H](CNc1cccc(-c2sccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	42625741	12603	None	0	Human	Functional	pEC50	=	5.9	5.9	-158	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCCOCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1186940	12603	None	0	Human	Functional	pEC50	=	5.9	5.9	-158	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCCOCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483202	12603	None	0	Human	Functional	pEC50	=	5.9	5.9	-158	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCCOCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	42625898	185361	None	0	Human	Functional	pEC50	=	5.9	5.9	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	591	17	7	9	1.5	NS(=O)(=O)O.NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL485847	185361	None	0	Human	Functional	pEC50	=	5.9	5.9	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	591	17	7	9	1.5	NS(=O)(=O)O.NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	145983711	165478	None	0	Human	Functional	pEC50	=	4.9	4.9	-2691	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	476	12	5	5	3.5	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)Nc3ccccc3)cc2)c1	10.1016/j.ejmech.2018.03.032
	CHEMBL4237802	165478	None	0	Human	Functional	pEC50	=	4.9	4.9	-2691	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	476	12	5	5	3.5	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)Nc3ccccc3)cc2)c1	10.1016/j.ejmech.2018.03.032
	24895265	186799	None	0	Human	Functional	pEC50	=	7.9	7.9	-70	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	409	8	3	3	5.0	C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm8000345
	CHEMBL488430	186799	None	0	Human	Functional	pEC50	=	7.9	7.9	-70	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	409	8	3	3	5.0	C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm8000345
	44392552	64547	None	0	Human	Functional	pEC50	=	7.9	7.9	-23	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	543	11	4	7	3.6	C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2ccccc2)c1	10.1016/j.bmcl.2004.12.033
	CHEMBL181440	64547	None	0	Human	Functional	pEC50	=	7.9	7.9	-23	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	543	11	4	7	3.6	C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2ccccc2)c1	10.1016/j.bmcl.2004.12.033
	155564340	175528	None	0	Human	Functional	pEC50	=	7.9	7.9	-263	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	493	11	5	5	4.9	CC(CC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)CC(C)(C)C	10.1016/j.bmc.2018.10.043
	CHEMBL4576089	175528	None	0	Human	Functional	pEC50	=	7.9	7.9	-263	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	493	11	5	5	4.9	CC(CC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)CC(C)(C)C	10.1016/j.bmc.2018.10.043
	44574826	178705	None	0	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	484	13	3	6	3.7	O=C(Cc1cn(Cc2ccccc2)cn1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL467301	178705	None	0	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	484	13	3	6	3.7	O=C(Cc1cn(Cc2ccccc2)cn1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	45270697	197626	None	0	Human	Functional	pEC50	=	6.9	6.9	-20	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	451	11	4	5	4.1	COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203995	197626	None	0	Human	Functional	pEC50	=	6.9	6.9	-20	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	451	11	4	5	4.1	COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL550444	197626	None	0	Human	Functional	pEC50	=	6.9	6.9	-20	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	451	11	4	5	4.1	COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	44580039	187056	None	0	Human	Functional	pEC50	=	6.9	6.9	-15	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	11	4	5	5.9	O=C(Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O)c1ccccc1	10.1016/j.bmcl.2008.08.009
	CHEMBL490222	187056	None	0	Human	Functional	pEC50	=	6.9	6.9	-15	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	11	4	5	5.9	O=C(Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O)c1ccccc1	10.1016/j.bmcl.2008.08.009
	45271036	197684	None	0	Human	Functional	pEC50	=	6.9	6.9	-2951	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	ChEMBL	526	11	4	7	3.8	CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3cccc(O)c3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1016/j.bmcl.2009.06.083
	CHEMBL550871	197684	None	0	Human	Functional	pEC50	=	6.9	6.9	-2951	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	ChEMBL	526	11	4	7	3.8	CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3cccc(O)c3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1016/j.bmcl.2009.06.083
	24895363	173695	None	0	Human	Functional	pEC50	=	6.9	6.9	-3162	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	447	11	3	4	5.3	CC(C)COc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL453322	173695	None	0	Human	Functional	pEC50	=	6.9	6.9	-3162	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	447	11	3	4	5.3	CC(C)COc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	24895261	186770	None	0	Human	Functional	pEC50	=	6.9	6.9	-676	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	435	10	4	6	3.7	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL488223	186770	None	0	Human	Functional	pEC50	=	6.9	6.9	-676	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	435	10	4	6	3.7	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	42639967	12516	None	0	Human	Functional	pEC50	=	6.9	6.9	-128	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	497	11	3	7	3.1	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL1186557	12516	None	0	Human	Functional	pEC50	=	6.9	6.9	-128	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	497	11	3	7	3.1	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL469610	12516	None	0	Human	Functional	pEC50	=	6.9	6.9	-128	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	497	11	3	7	3.1	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	44591506	179438	None	0	Human	Functional	pEC50	=	6.9	6.9	-676	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	435	10	4	6	3.7	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)O	10.1021/jm9000709
	CHEMBL473495	179438	None	0	Human	Functional	pEC50	=	6.9	6.9	-676	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	435	10	4	6	3.7	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)O	10.1021/jm9000709
	11152564	100069	None	0	Human	Functional	pEC50	=	6.9	6.9	-4	2	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	358	7	3	3	4.1	COc1cccc2c(C[C@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12	10.1016/s0960-894x(03)00073-8
	CHEMBL286818	100069	None	0	Human	Functional	pEC50	=	6.9	6.9	-4	2	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	358	7	3	3	4.1	COc1cccc2c(C[C@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12	10.1016/s0960-894x(03)00073-8
	44574651	178622	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	444	11	4	5	3.3	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL466704	178622	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	444	11	4	5	3.3	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1	10.1016/j.bmc.2009.03.044
	213051	92631	None	0	Human	Functional	pEC50	=	7.9	7.9	-4	2	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	402	9	4	4	3.5	C[C@@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	CHEMBL24350	92631	None	0	Human	Functional	pEC50	=	7.9	7.9	-4	2	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	402	9	4	4	3.5	C[C@@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	65772	60423	None	5	Human	Functional	pEC50	=	7.9	7.9	-5	11	Compound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptorCompound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptor	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1016/s0960-894x(00)00459-5
	CHEMBL174984	60423	None	5	Human	Functional	pEC50	=	7.9	7.9	-5	11	Compound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptorCompound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptor	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1016/s0960-894x(00)00459-5
	164623433	188679	None	0	Human	Functional	pEC50	=	7.8	7.8	-380	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4870623	188679	None	0	Human	Functional	pEC50	=	7.8	7.8	-380	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028756	188679	None	0	Human	Functional	pEC50	=	7.8	7.8	-380	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	9804536	165792	None	0	Human	Functional	pEC50	=	7.8	7.8	-7	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	465	11	4	5	3.5	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1)c1ccccc1	10.1016/j.ejmech.2018.03.032
	CHEMBL4245391	165792	None	0	Human	Functional	pEC50	=	7.8	7.8	-7	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	465	11	4	5	3.5	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1)c1ccccc1	10.1016/j.ejmech.2018.03.032
	44574825	178703	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	534	13	3	6	4.8	O=C(Cc1nc2ccccc2n1Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL467298	178703	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	534	13	3	6	4.8	O=C(Cc1nc2ccccc2n1Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	45273276	198140	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	429	10	4	5	3.6	N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204005	198140	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	429	10	4	5	3.6	N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL556689	198140	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	429	10	4	5	3.6	N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	44579966	192727	None	0	Human	Functional	pEC50	=	6.9	6.9	-15	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	429	9	3	4	4.8	O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)ccc1F	10.1016/j.bmcl.2008.08.009
	CHEMBL521611	192727	None	0	Human	Functional	pEC50	=	6.9	6.9	-15	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	429	9	3	4	4.8	O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)ccc1F	10.1016/j.bmcl.2008.08.009
	24949572	177131	None	0	Human	Functional	pEC50	=	6.9	6.9	-34	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	438	7	3	5	4.4	O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)c1	10.1021/jm800222k
	CHEMBL463182	177131	None	0	Human	Functional	pEC50	=	6.9	6.9	-34	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	438	7	3	5	4.4	O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)c1	10.1021/jm800222k
	44565931	12449	None	0	Human	Functional	pEC50	=	6.9	6.9	-4677	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	552	11	4	8	3.6	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	CHEMBL1186040	12449	None	0	Human	Functional	pEC50	=	6.9	6.9	-4677	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	552	11	4	8	3.6	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	CHEMBL446806	12449	None	0	Human	Functional	pEC50	=	6.9	6.9	-4677	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	552	11	4	8	3.6	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	11381882	99356	None	0	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	328	6	3	2	4.1	C[C@@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	CHEMBL282039	99356	None	0	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	328	6	3	2	4.1	C[C@@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	155515718	170066	None	0	Human	Functional	pEC50	=	5.8	5.8	-2884	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	423	9	5	5	3.1	CC(C)C(=O)Nc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.bmc.2018.10.043
	CHEMBL4441752	170066	None	0	Human	Functional	pEC50	=	5.8	5.8	-2884	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	423	9	5	5	3.1	CC(C)C(=O)Nc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.bmc.2018.10.043
	24894317	173804	None	0	Human	Functional	pEC50	=	7.8	7.8	-22	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	467	11	3	4	5.6	CC(C)Cc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL453575	173804	None	0	Human	Functional	pEC50	=	7.8	7.8	-22	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	467	11	3	4	5.6	CC(C)Cc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	44392228	64883	None	0	Human	Functional	pEC50	=	7.8	7.8	-7	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	441	11	5	5	3.1	O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)NC1CCCCC1	10.1016/j.bmcl.2004.11.001
	CHEMBL182127	64883	None	0	Human	Functional	pEC50	=	7.8	7.8	-7	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	441	11	5	5	3.1	O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)NC1CCCCC1	10.1016/j.bmcl.2004.11.001
	1028	291	None	40	Guinea pig	Functional	pEC50	=	7.8	7.8	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	139148732	291	None	40	Guinea pig	Functional	pEC50	=	7.8	7.8	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	479	291	None	40	Guinea pig	Functional	pEC50	=	7.8	7.8	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	5816	291	None	40	Guinea pig	Functional	pEC50	=	7.8	7.8	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	5816.0	291	None	40	Guinea pig	Functional	pEC50	=	7.8	7.8	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	CHEMBL679	291	None	40	Guinea pig	Functional	pEC50	=	7.8	7.8	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	DB00668	291	None	40	Guinea pig	Functional	pEC50	=	7.8	7.8	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	155524038	170994	None	0	Human	Functional	pEC50	=	7.8	7.8	-120	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	414	8	4	4	4.2	O=c1ccc2c(C(O)CNCCCc3ccc(-c4ccccc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4454489	170994	None	0	Human	Functional	pEC50	=	7.8	7.8	-120	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	414	8	4	4	4.2	O=c1ccc2c(C(O)CNCCCc3ccc(-c4ccccc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	155550544	174413	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	388	7	4	4	3.6	O=c1ccc2c(C(O)CNCCCc3ccc4ccccc4c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4550290	174413	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	388	7	4	4	3.6	O=c1ccc2c(C(O)CNCCCc3ccc4ccccc4c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	44126933	198621	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	470	11	4	5	4.3	O=C(Cc1ccc2ccccc2c1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL561291	198621	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	470	11	4	5	4.3	O=C(Cc1ccc2ccccc2c1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	45268516	198699	None	0	Human	Functional	pEC50	=	6.8	6.8	-588	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	ChEMBL	605	13	5	9	2.8	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1016/j.bmcl.2009.06.083
	CHEMBL561743	198699	None	0	Human	Functional	pEC50	=	6.8	6.8	-588	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	ChEMBL	605	13	5	9	2.8	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1016/j.bmcl.2009.06.083
	16222940	186580	None	0	Human	Functional	pEC50	=	6.8	6.8	-2290	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	433	10	4	5	4.1	CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL487682	186580	None	0	Human	Functional	pEC50	=	6.8	6.8	-2290	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	433	10	4	5	4.1	CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	24895259	189405	None	0	Human	Functional	pEC50	=	6.8	6.8	-588	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	528	12	5	7	3.8	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL512147	189405	None	0	Human	Functional	pEC50	=	6.8	6.8	-588	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	528	12	5	7	3.8	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	44591507	179465	None	0	Human	Functional	pEC50	=	6.8	6.8	-2290	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	433	10	4	5	4.1	CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)O	10.1021/jm9000709
	CHEMBL473702	179465	None	0	Human	Functional	pEC50	=	6.8	6.8	-2290	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	433	10	4	5	4.1	CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)O	10.1021/jm9000709
	9842600	188222	None	0	Human	Functional	pEC50	=	5.8	5.8	-38	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	375	7	3	4	3.0	O=C(O)COc1ccc2c(c1)C[C@@H](NC[C@H](O)c1cccc(Cl)c1)CC2	10.1021/jm800222k
	CHEMBL498305	188222	None	0	Human	Functional	pEC50	=	5.8	5.8	-38	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	375	7	3	4	3.0	O=C(O)COc1ccc2c(c1)C[C@@H](NC[C@H](O)c1cccc(Cl)c1)CC2	10.1021/jm800222k
	44377535	55433	None	0	Human	Functional	pEC50	=	5.8	5.8	-117	2	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	508	8	4	9	2.8	O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)Oc4cccc5nc(O)ccc45)CC3)cc2)S1	10.1016/s0960-894x(01)00063-4
	CHEMBL161949	55433	None	0	Human	Functional	pEC50	=	5.8	5.8	-117	2	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	508	8	4	9	2.8	O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)Oc4cccc5nc(O)ccc45)CC3)cc2)S1	10.1016/s0960-894x(01)00063-4
	56673609	64124	None	0	Human	Functional	pEC50	=	6.8	6.8	-112	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	499	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807873	64124	None	0	Human	Functional	pEC50	=	6.8	6.8	-112	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	499	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	56672116	66386	None	0	Human	Functional	pEC50	=	6.8	6.8	-630	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	570	19	5	8	2.4	NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	CHEMBL1814276	66386	None	0	Human	Functional	pEC50	=	6.8	6.8	-630	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	570	19	5	8	2.4	NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	CHEMBL1851624	66386	None	0	Human	Functional	pEC50	=	6.8	6.8	-630	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	570	19	5	8	2.4	NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	44441227	148137	None	0	Human	Functional	pEC50	=	6.8	6.8	-10	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	9	4	6	3.8	C[C@H](CNc1cccc(-c2nc(C(=O)O)co2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL393469	148137	None	0	Human	Functional	pEC50	=	6.8	6.8	-10	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	9	4	6	3.8	C[C@H](CNc1cccc(-c2nc(C(=O)O)co2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	145981079	166777	None	0	Human	Functional	pEC50	=	5.8	5.8	-39	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	358	6	4	4	2.8	O=c1ccc2c(C(CO)NCCc3ccc(Cl)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2018.04.041
	CHEMBL4282047	166777	None	0	Human	Functional	pEC50	=	5.8	5.8	-39	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	358	6	4	4	2.8	O=c1ccc2c(C(CO)NCCc3ccc(Cl)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2018.04.041
	164626310	188702	None	0	Human	Functional	pEC50	=	7.8	7.8	-346	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4874945	188702	None	0	Human	Functional	pEC50	=	7.8	7.8	-346	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5028930	188702	None	0	Human	Functional	pEC50	=	7.8	7.8	-346	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	164614249	188601	None	0	Human	Functional	pEC50	=	7.8	7.8	-295	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4859591	188601	None	0	Human	Functional	pEC50	=	7.8	7.8	-295	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028241	188601	None	0	Human	Functional	pEC50	=	7.8	7.8	-295	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	24949889	188261	None	0	Human	Functional	pEC50	=	6.8	6.8	-35	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	451	7	3	4	5.4	O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CCC3)c1	10.1021/jm800222k
	CHEMBL498531	188261	None	0	Human	Functional	pEC50	=	6.8	6.8	-35	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	451	7	3	4	5.4	O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CCC3)c1	10.1021/jm800222k
	42639311	12528	None	0	Human	Functional	pEC50	=	6.8	6.8	-56	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	524	14	3	6	4.5	CCCCCOc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL1186600	12528	None	0	Human	Functional	pEC50	=	6.8	6.8	-56	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	524	14	3	6	4.5	CCCCCOc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL472089	12528	None	0	Human	Functional	pEC50	=	6.8	6.8	-56	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	524	14	3	6	4.5	CCCCCOc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	44392558	65276	None	0	Human	Functional	pEC50	=	6.8	6.8	-2	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	471	11	4	6	4.1	CC(C)=CCNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1	10.1016/j.bmcl.2004.12.033
	CHEMBL182770	65276	None	0	Human	Functional	pEC50	=	6.8	6.8	-2	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	471	11	4	6	4.1	CC(C)=CCNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1	10.1016/j.bmcl.2004.12.033
	44237669	58252	None	0	Rat	Functional	pEC50	=	5.8	5.8	-7943	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	540	9	6	5	4.7	O=C(NCc1c(Cl)cccc1Cl)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682217	58252	None	0	Rat	Functional	pEC50	=	5.8	5.8	-7943	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	540	9	6	5	4.7	O=C(NCc1c(Cl)cccc1Cl)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	9933039	163140	None	0	Human	Functional	pEC50	=	5.8	5.8	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	442	11	4	6	2.8	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL417613	163140	None	0	Human	Functional	pEC50	=	5.8	5.8	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	442	11	4	6	2.8	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	9933039	163140	None	0	Human	Functional	pEC50	=	5.8	5.8	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	442	11	4	6	2.8	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1	10.1016/j.ejmech.2009.01.022
	CHEMBL417613	163140	None	0	Human	Functional	pEC50	=	5.8	5.8	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	442	11	4	6	2.8	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1	10.1016/j.ejmech.2009.01.022
	44309523	102244	None	0	Human	Functional	pEC50	=	5.8	5.8	-52	3	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	420	10	3	6	2.3	CCCCOc1ccc(S(=O)(=O)N2CC(NC[C@H](O)c3ccc(O)cc3)C2)cc1	10.1016/s0960-894x(03)00387-1
	CHEMBL302803	102244	None	0	Human	Functional	pEC50	=	5.8	5.8	-52	3	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	420	10	3	6	2.3	CCCCOc1ccc(S(=O)(=O)N2CC(NC[C@H](O)c3ccc(O)cc3)C2)cc1	10.1016/s0960-894x(03)00387-1
	10601234	112070	None	0	Human	Functional	pEC50	=	5.8	5.8	-23	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	493	11	5	8	1.7	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(COCC(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	CHEMBL32888	112070	None	0	Human	Functional	pEC50	=	5.8	5.8	-23	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	493	11	5	8	1.7	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(COCC(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	10140889	6068	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	484	12	4	6	3.3	CCN(CC)C(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL108061	6068	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	484	12	4	6	3.3	CCN(CC)C(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	44574978	189399	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	524	12	2	6	4.0	O=C(Cc1nccn1Cc1ccccc1)N1CCCc2cc(CCNC[C@H](O)COc3ccccc3)ccc21	10.1016/j.bmc.2009.03.044
	CHEMBL512099	189399	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	524	12	2	6	4.0	O=C(Cc1nccn1Cc1ccccc1)N1CCCc2cc(CCNC[C@H](O)COc3ccccc3)ccc21	10.1016/j.bmc.2009.03.044
	24823464	97671	None	0	Human	Functional	pEC50	=	6.8	6.8	-588	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	418	10	4	4	4.7	CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm701324c
	CHEMBL270964	97671	None	0	Human	Functional	pEC50	=	6.8	6.8	-588	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	418	10	4	4	4.7	CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm701324c
	24823464	97671	None	0	Human	Functional	pEC50	=	6.8	6.8	-588	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	418	10	4	4	4.7	CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm9000709
	CHEMBL270964	97671	None	0	Human	Functional	pEC50	=	6.8	6.8	-588	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	418	10	4	4	4.7	CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm9000709
	44392457	166052	None	0	Human	Functional	pEC50	=	6.8	6.8	-34	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	457	11	4	6	3.7	C/C=C/CNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1	10.1016/j.bmcl.2004.12.033
	CHEMBL425161	166052	None	0	Human	Functional	pEC50	=	6.8	6.8	-34	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	457	11	4	6	3.7	C/C=C/CNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1	10.1016/j.bmcl.2004.12.033
	44127677	197861	None	0	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	471	11	4	6	3.7	O=C(Cc1ccc2ccccc2n1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL552089	197861	None	0	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	471	11	4	6	3.7	O=C(Cc1ccc2ccccc2n1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	567	725	None	16	Human	Functional	pEC50	=	5.8	5.8	-323	7	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	363	9	3	4	3.1	C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O	10.1016/s0960-894x(03)00073-8
	9841972	725	None	16	Human	Functional	pEC50	=	5.8	5.8	-323	7	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	363	9	3	4	3.1	C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O	10.1016/s0960-894x(03)00073-8
	CHEMBL284782	725	None	16	Human	Functional	pEC50	=	5.8	5.8	-323	7	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	363	9	3	4	3.1	C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O	10.1016/s0960-894x(03)00073-8
	11703823	203612	None	0	Human	Functional	pEC50	=	6.8	6.8	-131	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	390	6	4	5	3.0	CC(C)(Cc1ccc(Cl)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL603274	203612	None	0	Human	Functional	pEC50	=	6.8	6.8	-131	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	390	6	4	5	3.0	CC(C)(Cc1ccc(Cl)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	24950234	176101	None	0	Human	Functional	pEC50	=	6.8	6.8	-223	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	494	10	4	5	5.8	CCCNc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1	10.1021/jm800222k
	CHEMBL458923	176101	None	0	Human	Functional	pEC50	=	6.8	6.8	-223	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	494	10	4	5	5.8	CCCNc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1	10.1021/jm800222k
	131487	4983	None	9	Guinea pig	Functional	pEC50	=	6.8	6.8	-	1	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	273	5	4	5	1.4	CC(C)(C)NCC(O)COc1cc(O)c(O)cc1F	10.1021/jm00107a027
	CHEMBL10494	4983	None	9	Guinea pig	Functional	pEC50	=	6.8	6.8	-	1	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	273	5	4	5	1.4	CC(C)(C)NCC(O)COc1cc(O)c(O)cc1F	10.1021/jm00107a027
	24822648	97660	None	0	Human	Functional	pEC50	=	7.8	7.8	-28	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	425	9	3	4	4.6	COc1cc(C(=O)O)ccc1-c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1	10.1021/jm701324c
	CHEMBL270889	97660	None	0	Human	Functional	pEC50	=	7.8	7.8	-28	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	425	9	3	4	4.6	COc1cc(C(=O)O)ccc1-c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1	10.1021/jm701324c
	45484558	199290	None	0	Human	Functional	pEC50	=	7.8	7.8	-4	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	498	11	8	7	1.6	CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL565770	199290	None	0	Human	Functional	pEC50	=	7.8	7.8	-4	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	498	11	8	7	1.6	CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	44574687	178626	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	406	11	3	6	2.2	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccnc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL466713	178626	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	406	11	3	6	2.2	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccnc2)cc1	10.1016/j.bmc.2009.03.044
	44219629	178674	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	484	13	3	6	3.7	O=C(Cc1nccn1Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL467083	178674	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	484	13	3	6	3.7	O=C(Cc1nccn1Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	44126931	197810	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	496	12	4	5	4.7	O=C(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2009.01.022
	CHEMBL551831	197810	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	496	12	4	5	4.7	O=C(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2009.01.022
	24895664	176801	None	0	Human	Functional	pEC50	=	6.8	6.8	-251	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	467	12	3	4	5.8	CCCOc1cc(-c2ccc(CCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL459863	176801	None	0	Human	Functional	pEC50	=	6.8	6.8	-251	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	467	12	3	4	5.8	CCCOc1cc(-c2ccc(CCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	44396568	67307	None	0	Human	Functional	pEC50	=	6.8	6.8	-34	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	529	12	5	7	3.7	C[C@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	CHEMBL188196	67307	None	0	Human	Functional	pEC50	=	6.8	6.8	-34	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	529	12	5	7	3.7	C[C@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	9853471	207312	None	0	Human	Functional	pEC50	=	5.8	5.8	-389	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL75604	207312	None	0	Human	Functional	pEC50	=	5.8	5.8	-389	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1	10.1016/s0960-894x(00)00459-5
	44331425	4446	None	0	Human	Functional	pEC50	=	5.7	5.7	-186	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	576	13	6	8	2.5	CC(C)C[C@H](NC(=O)c1ccc(N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1)C(=O)O	10.1016/s0960-894x(02)00608-x
	CHEMBL101630	4446	None	0	Human	Functional	pEC50	=	5.7	5.7	-186	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	576	13	6	8	2.5	CC(C)C[C@H](NC(=O)c1ccc(N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1)C(=O)O	10.1016/s0960-894x(02)00608-x
	45483838	199388	None	0	Human	Functional	pEC50	=	5.7	5.7	-14	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	383	7	4	4	3.5	CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2009.10.013
	CHEMBL566352	199388	None	0	Human	Functional	pEC50	=	5.7	5.7	-14	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	383	7	4	4	3.5	CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2009.10.013
	10302342	109842	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	538	14	5	6	4.5	O=C(NCCCC1CCCC1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL323258	109842	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	538	14	5	6	4.5	O=C(NCCCC1CCCC1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	44396488	66752	None	0	Human	Functional	pEC50	=	7.7	7.7	-14	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	556	12	4	7	3.8	C[C@H](Cc1c[nH]c2c(OCC(=O)N(C)C)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	CHEMBL185703	66752	None	0	Human	Functional	pEC50	=	7.7	7.7	-14	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	556	12	4	7	3.8	C[C@H](Cc1c[nH]c2c(OCC(=O)N(C)C)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	9831168	207160	None	0	Human	Functional	pEC50	=	7.7	7.7	-2	3	Percent adenylyl cyclase activation at 10000 nM of compound concentrationPercent adenylyl cyclase activation at 10000 nM of compound concentration	ChEMBL	552	11	6	6	5.0	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL74085	207160	None	0	Human	Functional	pEC50	=	7.7	7.7	-2	3	Percent adenylyl cyclase activation at 10000 nM of compound concentrationPercent adenylyl cyclase activation at 10000 nM of compound concentration	ChEMBL	552	11	6	6	5.0	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)cc1	10.1016/s0960-894x(00)00459-5
	11005613	119863	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	501	12	4	5	4.3	Cc1ccc(S(=O)(=O)NCCc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm0101500
	CHEMBL348269	119863	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	501	12	4	5	4.3	Cc1ccc(S(=O)(=O)NCCc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm0101500
	44441234	93842	None	0	Human	Functional	pEC50	=	7.7	7.7	-63	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	414	9	4	5	4.4	C[C@H](CNc1ccc(-c2occc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL247520	93842	None	0	Human	Functional	pEC50	=	7.7	7.7	-63	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	414	9	4	5	4.4	C[C@H](CNc1ccc(-c2occc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	44441228	167875	None	0	Human	Functional	pEC50	=	7.7	7.7	-3	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	431	9	4	6	4.3	C[C@H](CNc1ccc(-c2nc(C(=O)O)cs2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL430390	167875	None	0	Human	Functional	pEC50	=	7.7	7.7	-3	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	431	9	4	6	4.3	C[C@H](CNc1ccc(-c2nc(C(=O)O)cs2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	46832507	14219	None	0	Human	Functional	pEC50	=	7.7	7.7	-12	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	475	17	6	7	2.8	NC(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL1085638	14219	None	0	Human	Functional	pEC50	=	7.7	7.7	-12	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	475	17	6	7	2.8	NC(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL1198915	14219	None	0	Human	Functional	pEC50	=	7.7	7.7	-12	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	475	17	6	7	2.8	NC(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	10203169	14244	None	0	Human	Functional	pEC50	=	7.7	7.7	-25	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	433	16	5	7	3.0	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc(O)c2)ccc1O	10.1021/jm100326d
	CHEMBL1086536	14244	None	0	Human	Functional	pEC50	=	7.7	7.7	-25	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	433	16	5	7	3.0	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc(O)c2)ccc1O	10.1021/jm100326d
	CHEMBL1199300	14244	None	0	Human	Functional	pEC50	=	7.7	7.7	-25	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	433	16	5	7	3.0	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc(O)c2)ccc1O	10.1021/jm100326d
	44574867	178678	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	562	13	3	6	4.4	O=C(Cc1nccn1Cc1ccc(Br)cc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL467102	178678	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	562	13	3	6	4.4	O=C(Cc1nccn1Cc1ccc(Br)cc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	44579650	187261	None	0	Human	Functional	pEC50	=	6.7	6.7	-15	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	435	10	4	6	3.4	CC(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	CHEMBL492005	187261	None	0	Human	Functional	pEC50	=	6.7	6.7	-15	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	435	10	4	6	3.4	CC(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	44580041	193417	None	0	Human	Functional	pEC50	=	6.7	6.7	-9	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	11	4	5	5.9	O=C(O)c1cc(NC(=O)c2ccccc2)cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)c1	10.1016/j.bmcl.2008.08.009
	CHEMBL524145	193417	None	0	Human	Functional	pEC50	=	6.7	6.7	-9	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	11	4	5	5.9	O=C(O)c1cc(NC(=O)c2ccccc2)cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)c1	10.1016/j.bmcl.2008.08.009
	44127480	199013	None	0	Human	Functional	pEC50	=	6.7	6.7	6	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	454	11	4	5	3.8	O=C(Cc1ccc(Cl)cc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL563810	199013	None	0	Human	Functional	pEC50	=	6.7	6.7	6	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	454	11	4	5	3.8	O=C(Cc1ccc(Cl)cc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	44560793	189005	None	0	Human	Functional	pEC50	=	6.7	6.7	-2951	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	434	11	3	5	4.5	CCCOc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccnc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL507506	189005	None	0	Human	Functional	pEC50	=	6.7	6.7	-2951	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	434	11	3	5	4.5	CCCOc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccnc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	9873257	84979	None	14	Human	Functional	pEC50	=	5.7	5.7	-74	3	Agonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclaseAgonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase	ChEMBL	591	14	3	10	3.5	O=c1n(CCCC2CCCC2)nnn1-c1ccc(S(=O)(=O)Nc2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1	10.1016/s0960-894x(99)00182-1
	CHEMBL22375	84979	None	14	Human	Functional	pEC50	=	5.7	5.7	-74	3	Agonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclaseAgonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase	ChEMBL	591	14	3	10	3.5	O=c1n(CCCC2CCCC2)nnn1-c1ccc(S(=O)(=O)Nc2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1	10.1016/s0960-894x(99)00182-1
	155527926	171356	None	0	Human	Functional	pEC50	=	5.7	5.7	-8709	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	451	11	5	5	3.9	CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	CHEMBL4460095	171356	None	0	Human	Functional	pEC50	=	5.7	5.7	-8709	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	451	11	5	5	3.9	CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	164612026	185475	None	0	Human	Functional	pEC50	=	6.7	6.7	-776	2	Agonist activity at human beta1 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at human beta1 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assay	ChEMBL	237	4	3	4	1.3	CC(C)NC(CO)c1cc(F)c(N)c(C#N)c1	10.1021/acs.jmedchem.0c01195
	CHEMBL4860455	185475	None	0	Human	Functional	pEC50	=	6.7	6.7	-776	2	Agonist activity at human beta1 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at human beta1 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assay	ChEMBL	237	4	3	4	1.3	CC(C)NC(CO)c1cc(F)c(N)c(C#N)c1	10.1021/acs.jmedchem.0c01195
	56670092	64125	None	0	Human	Functional	pEC50	=	6.7	6.7	-112	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	445	13	4	7	2.5	CN(CCOCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)CCc1ccccc1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807874	64125	None	0	Human	Functional	pEC50	=	6.7	6.7	-112	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	445	13	4	7	2.5	CN(CCOCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)CCc1ccccc1	10.1016/j.bmcl.2011.05.097
	56675509	64517	None	0	Human	Functional	pEC50	=	6.7	6.7	-79	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CNC(=O)N1c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814270	64517	None	0	Human	Functional	pEC50	=	6.7	6.7	-79	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CNC(=O)N1c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmc.2011.05.064
	53357712	66428	None	0	Human	Functional	pEC50	=	6.7	6.7	-251	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	541	17	5	7	3.9	CC1(C)NC(=O)N(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	CHEMBL1814271	66428	None	0	Human	Functional	pEC50	=	6.7	6.7	-251	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	541	17	5	7	3.9	CC1(C)NC(=O)N(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	CHEMBL1851848	66428	None	0	Human	Functional	pEC50	=	6.7	6.7	-251	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	541	17	5	7	3.9	CC1(C)NC(=O)N(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	56658244	66429	None	0	Human	Functional	pEC50	=	6.7	6.7	-79	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1	10.1016/j.bmc.2011.05.064
	CHEMBL1814272	66429	None	0	Human	Functional	pEC50	=	6.7	6.7	-79	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1	10.1016/j.bmc.2011.05.064
	CHEMBL1851849	66429	None	0	Human	Functional	pEC50	=	6.7	6.7	-79	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1	10.1016/j.bmc.2011.05.064
	9958539	103160	None	0	Human	Functional	pEC50	=	8.7	8.7	-5	3	Percent adenylyl cyclase activation at 10000 nM of compound concentrationPercent adenylyl cyclase activation at 10000 nM of compound concentration	ChEMBL	527	3	2	5	3.4	COc1c(I)cc(CC2NCCc3nc(N)sc32)cc1I	10.1016/s0960-894x(00)00459-5
	CHEMBL307647	103160	None	0	Human	Functional	pEC50	=	8.7	8.7	-5	3	Percent adenylyl cyclase activation at 10000 nM of compound concentrationPercent adenylyl cyclase activation at 10000 nM of compound concentration	ChEMBL	527	3	2	5	3.4	COc1c(I)cc(CC2NCCc3nc(N)sc32)cc1I	10.1016/s0960-894x(00)00459-5
	164615222	188613	None	0	Human	Functional	pEC50	=	8.7	8.7	-91	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4857267	188613	None	0	Human	Functional	pEC50	=	8.7	8.7	-91	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028301	188613	None	0	Human	Functional	pEC50	=	8.7	8.7	-91	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164615492	188616	None	0	Human	Functional	pEC50	=	8.7	8.7	-120	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848704	188616	None	0	Human	Functional	pEC50	=	8.7	8.7	-120	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028319	188616	None	0	Human	Functional	pEC50	=	8.7	8.7	-120	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	443372	10236	None	19	Guinea pig	Functional	pEC50	=	8.7	8.7	-8	9	Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.	ChEMBL	211	4	4	4	1.1	CC(C)NC[C@H](O)c1ccc(O)c(O)c1	10.1021/jm00019a001
	CHEMBL1160723	10236	None	19	Guinea pig	Functional	pEC50	=	8.7	8.7	-8	9	Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.	ChEMBL	211	4	4	4	1.1	CC(C)NC[C@H](O)c1ccc(O)c(O)c1	10.1021/jm00019a001
	CHEMBL2062275	10236	None	19	Guinea pig	Functional	pEC50	=	8.7	8.7	-8	9	Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.	ChEMBL	211	4	4	4	1.1	CC(C)NC[C@H](O)c1ccc(O)c(O)c1	10.1021/jm00019a001
	44392215	65623	None	0	Human	Functional	pEC50	=	8.7	8.7	1	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	465	12	5	6	3.3	COc1ccc(NC(=O)Nc2ccc(C[C@@H](CO)NC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmcl.2004.11.001
	CHEMBL183307	65623	None	0	Human	Functional	pEC50	=	8.7	8.7	1	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	465	12	5	6	3.3	COc1ccc(NC(=O)Nc2ccc(C[C@@H](CO)NC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmcl.2004.11.001
	5311116	2334	None	9	Human	Functional	pEC50	=	8.6	8.6	4365	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	484	15	5	8	2.2	N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O	10.1021/jm400348g
	544	2334	None	9	Human	Functional	pEC50	=	8.6	8.6	4365	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	484	15	5	8	2.2	N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O	10.1021/jm400348g
	CHEMBL207802	2334	None	9	Human	Functional	pEC50	=	8.6	8.6	4365	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	484	15	5	8	2.2	N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O	10.1021/jm400348g
	56598832	88302	None	0	Human	Functional	pEC50	=	8.6	8.6	4365	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	527	16	5	7	3.3	O=C(NCCNCC(O)COc1ccc(OCCOCCc2ccc(F)cc2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	CHEMBL2348218	88302	None	0	Human	Functional	pEC50	=	8.6	8.6	4365	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	527	16	5	7	3.3	O=C(NCCNCC(O)COc1ccc(OCCOCCc2ccc(F)cc2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	164617772	188631	None	0	Human	Functional	pEC50	=	8.6	8.6	-173	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848793	188631	None	0	Human	Functional	pEC50	=	8.6	8.6	-173	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028458	188631	None	0	Human	Functional	pEC50	=	8.6	8.6	-173	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164611794	188582	None	0	Human	Functional	pEC50	=	8.6	8.6	-131	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4854261	188582	None	0	Human	Functional	pEC50	=	8.6	8.6	-131	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028104	188582	None	0	Human	Functional	pEC50	=	8.6	8.6	-131	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	10289065	12549	None	0	Guinea pig	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1186683	12549	None	0	Guinea pig	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL474616	12549	None	0	Guinea pig	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	42625511	12741	None	0	Guinea pig	Functional	pEC50	=	8.6	8.6	-3	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm801016j
	CHEMBL1187778	12741	None	0	Guinea pig	Functional	pEC50	=	8.6	8.6	-3	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm801016j
	CHEMBL520313	12741	None	0	Guinea pig	Functional	pEC50	=	8.6	8.6	-3	4	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm801016j
	90645344	112519	None	0	Human	Functional	pEC50	=	8.6	8.6	-7	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1CN	10.1016/j.bmcl.2014.04.095
	CHEMBL3298324	112519	None	0	Human	Functional	pEC50	=	8.6	8.6	-7	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1CN	10.1016/j.bmcl.2014.04.095
	10239722	112521	None	0	Human	Functional	pEC50	=	8.6	8.6	-11	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298326	112521	None	0	Human	Functional	pEC50	=	8.6	8.6	-11	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1	10.1016/j.bmcl.2014.04.095
	164621302	188658	None	0	Human	Functional	pEC50	=	8.6	8.6	-120	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4863282	188658	None	0	Human	Functional	pEC50	=	8.6	8.6	-120	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028641	188658	None	0	Human	Functional	pEC50	=	8.6	8.6	-120	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	164610792	188575	None	0	Human	Functional	pEC50	=	8.6	8.6	-134	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4855974	188575	None	0	Human	Functional	pEC50	=	8.6	8.6	-134	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028040	188575	None	0	Human	Functional	pEC50	=	8.6	8.6	-134	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	145984584	165982	None	0	Human	Functional	pEC50	=	8.5	8.5	-5	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	444	10	5	4	4.4	O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1	10.1016/j.ejmech.2018.03.032
	CHEMBL4249564	165982	None	0	Human	Functional	pEC50	=	8.5	8.5	-5	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	444	10	5	4	4.4	O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1	10.1016/j.ejmech.2018.03.032
	24822643	157746	None	0	Human	Functional	pEC50	=	7.7	7.7	-4	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	413	8	3	3	4.7	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c(F)c1	10.1021/jm701324c
	CHEMBL408145	157746	None	0	Human	Functional	pEC50	=	7.7	7.7	-4	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	413	8	3	3	4.7	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c(F)c1	10.1021/jm701324c
	44392212	168472	None	0	Human	Functional	pEC50	=	7.7	7.7	12	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	405	10	4	4	3.9	O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204383	168472	None	0	Human	Functional	pEC50	=	7.7	7.7	12	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	405	10	4	4	3.9	O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL434524	168472	None	0	Human	Functional	pEC50	=	7.7	7.7	12	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	405	10	4	4	3.9	O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	45271492	197690	None	0	Human	Functional	pEC50	=	7.7	7.7	16	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	390	10	3	4	3.5	O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203997	197690	None	0	Human	Functional	pEC50	=	7.7	7.7	16	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	390	10	3	4	3.5	O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL550906	197690	None	0	Human	Functional	pEC50	=	7.7	7.7	16	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	390	10	3	4	3.5	O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	10113837	65590	None	0	Human	Functional	pEC50	=	7.7	7.7	-39	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	435	11	5	5	3.3	O=C(Nc1ccccc1)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	CHEMBL183129	65590	None	0	Human	Functional	pEC50	=	7.7	7.7	-39	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	435	11	5	5	3.3	O=C(Nc1ccccc1)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	44396531	66856	None	0	Human	Functional	pEC50	=	7.7	7.7	-38	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	647	18	4	8	6.4	CCCCCCCCS(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12	10.1016/j.bmcl.2004.10.035
	CHEMBL186135	66856	None	0	Human	Functional	pEC50	=	7.7	7.7	-38	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	647	18	4	8	6.4	CCCCCCCCS(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12	10.1016/j.bmcl.2004.10.035
	24822469	97830	None	0	Human	Functional	pEC50	=	6.7	6.7	-26	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	401	8	3	4	4.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)s1	10.1021/jm701324c
	CHEMBL271765	97830	None	0	Human	Functional	pEC50	=	6.7	6.7	-26	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	401	8	3	4	4.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)s1	10.1021/jm701324c
	24950568	189874	None	0	Human	Functional	pEC50	=	6.7	6.7	-234	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	422	6	3	4	4.3	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)cc1	10.1021/jm800222k
	CHEMBL516002	189874	None	0	Human	Functional	pEC50	=	6.7	6.7	-234	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	422	6	3	4	4.3	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)cc1	10.1021/jm800222k
	11625493	203168	None	1	Human	Functional	pEC50	=	6.7	6.7	-12	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	400	8	4	6	2.8	CCOc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.12.087
	CHEMBL600007	203168	None	1	Human	Functional	pEC50	=	6.7	6.7	-12	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	400	8	4	6	2.8	CCOc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.12.087
	44565908	187230	None	0	Human	Functional	pEC50	=	6.7	6.7	-1513	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	512	11	4	8	2.7	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL491726	187230	None	0	Human	Functional	pEC50	=	6.7	6.7	-1513	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	512	11	4	8	2.7	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	10139127	57506	None	0	Human	Functional	pEC50	=	5.7	5.7	-50	2	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	455	9	3	7	2.6	O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)COc4ccccc4)CC3)cc2)S1	10.1016/s0960-894x(01)00063-4
	CHEMBL165893	57506	None	0	Human	Functional	pEC50	=	5.7	5.7	-50	2	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	455	9	3	7	2.6	O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)COc4ccccc4)CC3)cc2)S1	10.1016/s0960-894x(01)00063-4
	44589133	175948	None	0	Human	Functional	pEC50	=	5.7	5.7	-2	3	Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor	ChEMBL	354	8	2	4	3.4	CC(C)NCC(O)COc1ccc2c(c1)CCCN2Cc1ccccc1	10.1016/j.bmc.2008.11.030
	CHEMBL458541	175948	None	0	Human	Functional	pEC50	=	5.7	5.7	-2	3	Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor	ChEMBL	354	8	2	4	3.4	CC(C)NCC(O)COc1ccc2c(c1)CCCN2Cc1ccccc1	10.1016/j.bmc.2008.11.030
	10145446	4184	None	0	Human	Functional	pEC50	=	5.7	5.7	-102	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	602	14	5	8	3.6	O=C(NCCCc1cccs1)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	CHEMBL100124	4184	None	0	Human	Functional	pEC50	=	5.7	5.7	-102	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	602	14	5	8	3.6	O=C(NCCCc1cccs1)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	46232816	203411	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	432	7	4	5	4.0	CC(C)(Cc1ccc(-c2ccccc2)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL601858	203411	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	432	7	4	5	4.0	CC(C)(Cc1ccc(-c2ccccc2)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	11632691	203999	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	398	7	4	5	3.5	CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.12.087
	CHEMBL605372	203999	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	398	7	4	5	3.5	CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.12.087
	44377523	56247	None	0	Human	Functional	pEC50	=	7.7	7.7	1	2	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	509	9	3	8	1.0	O=C1N=c2cccc(OC[C@@H](O)CNC3CCN(c4ccc(CC5SC(=O)NC5=O)cc4)CC3)c2=N1	10.1016/s0960-894x(01)00063-4
	CHEMBL162711	56247	None	0	Human	Functional	pEC50	=	7.7	7.7	1	2	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	509	9	3	8	1.0	O=C1N=c2cccc(OC[C@@H](O)CNC3CCN(c4ccc(CC5SC(=O)NC5=O)cc4)CC3)c2=N1	10.1016/s0960-894x(01)00063-4
	9933039	163140	None	0	Human	Functional	pEC50	=	6.7	6.7	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	442	11	4	6	2.8	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL417613	163140	None	0	Human	Functional	pEC50	=	6.7	6.7	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	442	11	4	6	2.8	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	24895563	176843	None	0	Human	Functional	pEC50	=	6.7	6.7	-173	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	435	12	3	5	4.5	CCCOc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL460256	176843	None	0	Human	Functional	pEC50	=	6.7	6.7	-173	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	435	12	3	5	4.5	CCCOc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	11668125	203468	None	0	Human	Functional	pEC50	=	6.7	6.7	-4	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	384	7	4	5	2.9	CCc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.12.087
	CHEMBL602258	203468	None	0	Human	Functional	pEC50	=	6.7	6.7	-4	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	384	7	4	5	2.9	CCc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.12.087
	155536314	172278	None	0	Human	Functional	pEC50	=	6.7	6.7	-6025	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4473515	172278	None	0	Human	Functional	pEC50	=	6.7	6.7	-6025	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	24895789	188975	None	0	Human	Functional	pEC50	=	7.7	7.7	-72	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	375	8	3	3	4.3	C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1ccccc1	10.1021/jm8000345
	CHEMBL507003	188975	None	0	Human	Functional	pEC50	=	7.7	7.7	-72	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	375	8	3	3	4.3	C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1ccccc1	10.1021/jm8000345
	44396715	67472	None	0	Human	Functional	pEC50	=	7.7	7.7	-20	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	612	12	4	9	4.4	C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3cccnc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	CHEMBL189081	67472	None	0	Human	Functional	pEC50	=	7.7	7.7	-20	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	612	12	4	9	4.4	C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3cccnc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	155551006	174049	None	0	Human	Functional	pEC50	=	7.7	7.7	-44	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	423	9	5	5	3.1	CC(C)C(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	CHEMBL4541169	174049	None	0	Human	Functional	pEC50	=	7.7	7.7	-44	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	423	9	5	5	3.1	CC(C)C(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	164620585	188652	None	0	Human	Functional	pEC50	=	7.7	7.7	-616	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4866766	188652	None	0	Human	Functional	pEC50	=	7.7	7.7	-616	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028602	188652	None	0	Human	Functional	pEC50	=	7.7	7.7	-616	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	56598833	88301	None	0	Human	Functional	pEC50	=	7.6	7.6	436	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	433	14	5	7	2.0	CCOCCOc1ccc(OCC(O)CNCCNC(=O)Nc2ccc(O)cc2)cc1	10.1021/jm400348g
	CHEMBL2348217	88301	None	0	Human	Functional	pEC50	=	7.6	7.6	436	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	433	14	5	7	2.0	CCOCCOc1ccc(OCC(O)CNCCNC(=O)Nc2ccc(O)cc2)cc1	10.1021/jm400348g
	42639314	12574	None	0	Human	Functional	pEC50	=	6.7	6.7	-575	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	550	11	3	6	5.0	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCCC1	10.1021/jm9000709
	CHEMBL1186804	12574	None	0	Human	Functional	pEC50	=	6.7	6.7	-575	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	550	11	3	6	5.0	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCCC1	10.1021/jm9000709
	CHEMBL479341	12574	None	0	Human	Functional	pEC50	=	6.7	6.7	-575	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	550	11	3	6	5.0	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCCC1	10.1021/jm9000709
	443372	10236	None	19	Guinea pig	Functional	pEC50	=	5.7	5.7	-8	9	Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.	ChEMBL	211	4	4	4	1.1	CC(C)NC[C@H](O)c1ccc(O)c(O)c1	10.1021/jm00019a001
	CHEMBL1160723	10236	None	19	Guinea pig	Functional	pEC50	=	5.7	5.7	-8	9	Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.	ChEMBL	211	4	4	4	1.1	CC(C)NC[C@H](O)c1ccc(O)c(O)c1	10.1021/jm00019a001
	CHEMBL2062275	10236	None	19	Guinea pig	Functional	pEC50	=	5.7	5.7	-8	9	Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.	ChEMBL	211	4	4	4	1.1	CC(C)NC[C@H](O)c1ccc(O)c(O)c1	10.1021/jm00019a001
	145983266	165623	None	0	Human	Functional	pEC50	=	6.7	6.7	-66	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	512	14	5	6	2.7	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NS(=O)(=O)Nc3ccccc3)cc2)c1	10.1016/j.ejmech.2018.03.032
	CHEMBL4241176	165623	None	0	Human	Functional	pEC50	=	6.7	6.7	-66	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	512	14	5	6	2.7	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NS(=O)(=O)Nc3ccccc3)cc2)c1	10.1016/j.ejmech.2018.03.032
	319	1324	None	32	Rat	Functional	pEC50	=	5.6	5.6	-2290	18	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2010.12.096
	321	1324	None	32	Rat	Functional	pEC50	=	5.6	5.6	-2290	18	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2010.12.096
	444031	1324	None	32	Rat	Functional	pEC50	=	5.6	5.6	-2290	18	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2010.12.096
	444031.0	1324	None	32	Rat	Functional	pEC50	=	5.6	5.6	-2290	18	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2010.12.096
	784	1324	None	32	Rat	Functional	pEC50	=	5.6	5.6	-2290	18	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2010.12.096
	CHEMBL1346	1324	None	32	Rat	Functional	pEC50	=	5.6	5.6	-2290	18	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2010.12.096
	DB00496	1324	None	32	Rat	Functional	pEC50	=	5.6	5.6	-2290	18	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2010.12.096
	155543518	175102	None	0	Human	Functional	pEC50	=	6.6	6.6	-794	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	457	9	5	5	3.7	O=C(Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)c1ccccc1	10.1016/j.bmc.2018.10.043
	CHEMBL4566727	175102	None	0	Human	Functional	pEC50	=	6.6	6.6	-794	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	457	9	5	5	3.7	O=C(Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)c1ccccc1	10.1016/j.bmc.2018.10.043
	45101521	199283	None	0	Human	Functional	pEC50	=	7.6	7.6	-4	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	570	15	8	9	1.3	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C(N)CCCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL565747	199283	None	0	Human	Functional	pEC50	=	7.6	7.6	-4	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	570	15	8	9	1.3	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C(N)CCCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	44560794	173605	None	0	Human	Functional	pEC50	=	7.6	7.6	-346	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	474	10	3	5	5.4	C[C@H](Cc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1)NC[C@H](O)c1cccnc1	10.1021/jm8000345
	CHEMBL453056	173605	None	0	Human	Functional	pEC50	=	7.6	7.6	-346	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	474	10	3	5	5.4	C[C@H](Cc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1)NC[C@H](O)c1cccnc1	10.1021/jm8000345
	164623230	188678	None	0	Human	Functional	pEC50	=	7.6	7.6	-1479	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4865710	188678	None	0	Human	Functional	pEC50	=	7.6	7.6	-1479	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028744	188678	None	0	Human	Functional	pEC50	=	7.6	7.6	-1479	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	44579940	192001	None	0	Human	Functional	pEC50	=	6.6	6.6	-37	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	468	10	4	5	4.7	CC(=O)Nc1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc(C(=O)O)c1	10.1016/j.bmcl.2008.08.009
	CHEMBL519985	192001	None	0	Human	Functional	pEC50	=	6.6	6.6	-37	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	468	10	4	5	4.7	CC(=O)Nc1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc(C(=O)O)c1	10.1016/j.bmcl.2008.08.009
	46232857	203214	None	0	Human	Functional	pEC50	=	6.6	6.6	-19	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	440	7	4	6	3.3	CC(C)(Cc1ccc(OC(F)(F)F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL600400	203214	None	0	Human	Functional	pEC50	=	6.6	6.6	-19	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	440	7	4	6	3.3	CC(C)(Cc1ccc(OC(F)(F)F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	42639654	12644	None	0	Human	Functional	pEC50	=	6.6	6.6	-1258	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	513	11	3	7	3.8	CC(C)Sc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL1187156	12644	None	0	Human	Functional	pEC50	=	6.6	6.6	-1258	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	513	11	3	7	3.8	CC(C)Sc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL491891	12644	None	0	Human	Functional	pEC50	=	6.6	6.6	-1258	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	513	11	3	7	3.8	CC(C)Sc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	164615990	185408	None	0	Human	Functional	pEC50	=	5.6	5.6	-831	2	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by immunoassayAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by immunoassay	ChEMBL	427	9	5	6	1.6	CN(C)C(=O)CNc1ccc2c(c1)C[C@@H](NC[C@H](O)c1ccc(O)c(CCO)c1)CC2	10.1021/acs.jmedchem.0c01195
	CHEMBL4859326	185408	None	0	Human	Functional	pEC50	=	5.6	5.6	-831	2	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by immunoassayAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by immunoassay	ChEMBL	427	9	5	6	1.6	CN(C)C(=O)CNc1ccc2c(c1)C[C@@H](NC[C@H](O)c1ccc(O)c(CCO)c1)CC2	10.1021/acs.jmedchem.0c01195
	9832011	105537	None	0	Human	Functional	pEC50	=	5.6	5.6	-138	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	644	13	6	7	6.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(OCC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL312074	105537	None	0	Human	Functional	pEC50	=	5.6	5.6	-138	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	644	13	6	7	6.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(OCC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1	10.1016/s0960-894x(00)00459-5
	11091850	47245	None	0	Human	Functional	pEC50	=	7.6	7.6	-25	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	465	11	4	4	4.6	Cc1ccc(CNC(=O)Cc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm0101500
	CHEMBL154370	47245	None	0	Human	Functional	pEC50	=	7.6	7.6	-25	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	465	11	4	4	4.6	Cc1ccc(CNC(=O)Cc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm0101500
	44441232	93841	None	0	Human	Functional	pEC50	=	7.6	7.6	-19	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	9	4	6	3.8	C[C@H](CNc1ccc(-c2ocnc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL247519	93841	None	0	Human	Functional	pEC50	=	7.6	7.6	-19	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	9	4	6	3.8	C[C@H](CNc1ccc(-c2ocnc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	9892481	70257	None	12	Human	Functional	pEC50	=	7.6	7.6	-501	4	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2014.04.095
	CHEMBL1940832	70257	None	12	Human	Functional	pEC50	=	7.6	7.6	-501	4	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2014.04.095
	9849126	12443	None	0	Human	Functional	pEC50	=	7.6	7.6	-630	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	CHEMBL1185969	12443	None	0	Human	Functional	pEC50	=	7.6	7.6	-630	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	CHEMBL443435	12443	None	0	Human	Functional	pEC50	=	7.6	7.6	-630	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	9892481	70257	None	12	Human	Functional	pEC50	=	7.6	7.6	-501	4	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	CHEMBL1940832	70257	None	12	Human	Functional	pEC50	=	7.6	7.6	-501	4	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	44574720	178655	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	494	11	4	5	4.5	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]c4ccccc4c23)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL466923	178655	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	494	11	4	5	4.5	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]c4ccccc4c23)cc1	10.1016/j.bmc.2009.03.044
	49861320	54982	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	426	11	3	5	3.1	O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204003	54982	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	426	11	3	5	3.1	O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1615579	54982	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	426	11	3	5	3.1	O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	10048077	97947	None	16	Human	Functional	pEC50	=	6.6	6.6	-52	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	425	9	3	4	4.6	COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm9000709
	CHEMBL272383	97947	None	16	Human	Functional	pEC50	=	6.6	6.6	-52	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	425	9	3	4	4.6	COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm9000709
	44574757	178590	None	0	Human	Functional	pEC50	=	5.6	5.6	-12	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	511	14	3	6	4.4	O=C(Cc1cccc(OCc2ccccc2)n1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL466467	178590	None	0	Human	Functional	pEC50	=	5.6	5.6	-12	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	511	14	3	6	4.4	O=C(Cc1cccc(OCc2ccccc2)n1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	10048077	97947	None	16	Human	Functional	pEC50	=	6.6	6.6	-52	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	425	9	3	4	4.6	COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm701324c
	CHEMBL272383	97947	None	16	Human	Functional	pEC50	=	6.6	6.6	-52	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	425	9	3	4	4.6	COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm701324c
	11003341	46311	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	376	10	4	4	3.5	C[C@H](CNc1ccc(CCC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL153558	46311	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	376	10	4	4	3.5	C[C@H](CNc1ccc(CCC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	56658246	64518	None	0	Human	Functional	pEC50	=	6.6	6.6	-1258	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	525	17	5	8	2.9	O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814277	64518	None	0	Human	Functional	pEC50	=	6.6	6.6	-1258	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	525	17	5	8	2.9	O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814278	64518	None	0	Human	Functional	pEC50	=	6.6	6.6	-1258	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	525	17	5	8	2.9	O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	11003341	46311	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	376	10	4	4	3.5	C[C@H](CNc1ccc(CCC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL153558	46311	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	376	10	4	4	3.5	C[C@H](CNc1ccc(CCC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	2419	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	5152	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	5152.0	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	559	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	DB00938	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	42625511	12741	None	0	Human	Functional	pEC50	=	6.6	6.6	-316	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm801016j
	CHEMBL1187778	12741	None	0	Human	Functional	pEC50	=	6.6	6.6	-316	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm801016j
	CHEMBL520313	12741	None	0	Human	Functional	pEC50	=	6.6	6.6	-316	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm801016j
	2419	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.069
	5152	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.069
	5152.0	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.069
	559	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.069
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.069
	DB00938	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.069
	2419	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.11.072
	5152	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.11.072
	5152.0	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.11.072
	559	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.11.072
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.11.072
	DB00938	3463	None	53	Human	Functional	pEC50	=	6.6	6.6	-977	19	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.11.072
	10180590	70255	None	0	Human	Functional	pEC50	=	6.6	6.6	-707	2	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	422	11	6	6	2.9	OCc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	CHEMBL1940830	70255	None	0	Human	Functional	pEC50	=	6.6	6.6	-707	2	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	422	11	6	6	2.9	OCc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	10202462	70256	None	0	Human	Functional	pEC50	=	6.6	6.6	-223	2	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	422	11	6	6	2.9	OCc1cc([C@@H](O)CNCCc2ccc(NC[C@@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	CHEMBL1940831	70256	None	0	Human	Functional	pEC50	=	6.6	6.6	-223	2	Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	422	11	6	6	2.9	OCc1cc([C@@H](O)CNCCc2ccc(NC[C@@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	11669967	76547	None	0	Human	Functional	pEC50	=	5.6	5.6	-12589	2	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	468	10	5	5	4.5	C[C@H](CNc1cccc(-c2ccc(C(=O)O)cc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	CHEMBL206002	76547	None	0	Human	Functional	pEC50	=	5.6	5.6	-12589	2	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	468	10	5	5	4.5	C[C@H](CNc1cccc(-c2ccc(C(=O)O)cc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	45375919	199467	None	0	Human	Functional	pEC50	=	6.6	6.6	-87	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	400	7	5	6	2.1	CC(C)(Cc1cccc(C(=O)O)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL566973	199467	None	0	Human	Functional	pEC50	=	6.6	6.6	-87	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	400	7	5	6	2.1	CC(C)(Cc1cccc(C(=O)O)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	10232096	107721	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	586	12	5	6	5.1	O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL319041	107721	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	586	12	5	6	5.1	O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	44396530	67109	None	0	Human	Functional	pEC50	=	7.6	7.6	-23	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	591	14	4	8	4.8	CCCCS(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12	10.1016/j.bmcl.2004.10.035
	CHEMBL187317	67109	None	0	Human	Functional	pEC50	=	7.6	7.6	-23	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	591	14	4	8	4.8	CCCCS(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12	10.1016/j.bmcl.2004.10.035
	44396798	169495	None	0	Human	Functional	pEC50	=	7.6	7.6	-56	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	542	10	5	7	3.2	C[C@H](Cc1c[nH]c2c(S(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccc(N)c2)c1	10.1016/j.bmcl.2004.09.054
	CHEMBL442225	169495	None	0	Human	Functional	pEC50	=	7.6	7.6	-56	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	542	10	5	7	3.2	C[C@H](Cc1c[nH]c2c(S(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccc(N)c2)c1	10.1016/j.bmcl.2004.09.054
	45483846	199267	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	412	6	4	5	3.7	CC(C)(Cc1ccc(C(C)(C)C)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL565685	199267	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	412	6	4	5	3.7	CC(C)(Cc1ccc(C(C)(C)C)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	44574868	178679	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	534	13	3	6	4.8	O=C(Cc1nccn1Cc1ccc2ccccc2c1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL467103	178679	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	534	13	3	6	4.8	O=C(Cc1nccn1Cc1ccc2ccccc2c1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	24823131	97455	None	0	Human	Functional	pEC50	=	6.6	6.6	-15	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	429	8	3	3	5.2	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1Cl	10.1021/jm701324c
	CHEMBL269823	97455	None	0	Human	Functional	pEC50	=	6.6	6.6	-15	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	429	8	3	3	5.2	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1Cl	10.1021/jm701324c
	24823294	159161	None	0	Human	Functional	pEC50	=	6.6	6.6	-870	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	459	10	3	4	5.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1	10.1021/jm701324c
	CHEMBL409718	159161	None	0	Human	Functional	pEC50	=	6.6	6.6	-870	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	459	10	3	4	5.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1	10.1021/jm701324c
	44127374	198690	None	0	Human	Functional	pEC50	=	6.6	6.6	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	421	11	4	6	2.5	O=C(Cc1ccncc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL561693	198690	None	0	Human	Functional	pEC50	=	6.6	6.6	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	421	11	4	6	2.5	O=C(Cc1ccncc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	24823294	159161	None	0	Human	Functional	pEC50	=	6.6	6.6	-870	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	459	10	3	4	5.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1	10.1021/jm8000345
	CHEMBL409718	159161	None	0	Human	Functional	pEC50	=	6.6	6.6	-870	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	459	10	3	4	5.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1	10.1021/jm8000345
	11420551	12523	None	0	Human	Functional	pEC50	=	6.6	6.6	-436	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	495	11	4	6	3.7	CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL1186589	12523	None	0	Human	Functional	pEC50	=	6.6	6.6	-436	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	495	11	4	6	3.7	CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL471060	12523	None	0	Human	Functional	pEC50	=	6.6	6.6	-436	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	495	11	4	6	3.7	CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	24823294	159161	None	0	Human	Functional	pEC50	=	6.6	6.6	-870	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	459	10	3	4	5.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	CHEMBL409718	159161	None	0	Human	Functional	pEC50	=	6.6	6.6	-870	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	459	10	3	4	5.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	1028	291	None	40	Guinea pig	Functional	pEC50	=	6.6	6.6	-6	19	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	139148732	291	None	40	Guinea pig	Functional	pEC50	=	6.6	6.6	-6	19	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	479	291	None	40	Guinea pig	Functional	pEC50	=	6.6	6.6	-6	19	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	5816	291	None	40	Guinea pig	Functional	pEC50	=	6.6	6.6	-6	19	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	5816.0	291	None	40	Guinea pig	Functional	pEC50	=	6.6	6.6	-6	19	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	CHEMBL679	291	None	40	Guinea pig	Functional	pEC50	=	6.6	6.6	-6	19	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	DB00668	291	None	40	Guinea pig	Functional	pEC50	=	6.6	6.6	-6	19	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	10119515	108445	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	536	12	5	6	3.9	O=C(NCc1ccccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL319840	108445	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	536	12	5	6	3.9	O=C(NCc1ccccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	11758172	100988	None	0	Human	Functional	pEC50	=	5.6	5.6	-181	3	In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.	ChEMBL	592	11	3	7	5.8	O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(F)c(F)c3)cs2)cc1	10.1021/jm000286i
	CHEMBL293994	100988	None	0	Human	Functional	pEC50	=	5.6	5.6	-181	3	In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.	ChEMBL	592	11	3	7	5.8	O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(F)c(F)c3)cs2)cc1	10.1021/jm000286i
	44336319	6365	None	0	Human	Functional	pEC50	=	5.6	5.6	-524	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	617	12	6	7	3.7	CS(=O)(=O)Nc1cc([C@@H](O)CNCCc2ccc(NC3CCN(C(=O)NCc4cc(F)ccc4F)CC3)cc2)ccc1O	10.1016/s0960-894x(01)00645-x
	CHEMBL108214	6365	None	0	Human	Functional	pEC50	=	5.6	5.6	-524	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	617	12	6	7	3.7	CS(=O)(=O)Nc1cc([C@@H](O)CNCCc2ccc(NC3CCN(C(=O)NCc4cc(F)ccc4F)CC3)cc2)ccc1O	10.1016/s0960-894x(01)00645-x
	46232973	203244	None	0	Human	Functional	pEC50	=	7.6	7.6	-19	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	424	6	4	5	3.4	CC(C)(Cc1ccccc1C(F)(F)F)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL600617	203244	None	0	Human	Functional	pEC50	=	7.6	7.6	-19	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	424	6	4	5	3.4	CC(C)(Cc1ccccc1C(F)(F)F)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	44392255	166056	None	0	Human	Functional	pEC50	=	7.6	7.6	-5	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	401	11	5	5	2.1	CC(C)NC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	CHEMBL425173	166056	None	0	Human	Functional	pEC50	=	7.6	7.6	-5	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	401	11	5	5	2.1	CC(C)NC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	44574827	178737	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	518	13	3	6	4.3	O=C(Cc1nccn1Cc1ccc(Cl)cc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL467502	178737	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	518	13	3	6	4.3	O=C(Cc1nccn1Cc1ccc(Cl)cc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	24950401	177130	None	0	Human	Functional	pEC50	=	6.6	6.6	-147	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	481	8	3	6	4.5	CN(C)c1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)cc(C(=O)O)c1	10.1021/jm800222k
	CHEMBL463181	177130	None	0	Human	Functional	pEC50	=	6.6	6.6	-147	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	481	8	3	6	4.5	CN(C)c1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)cc(C(=O)O)c1	10.1021/jm800222k
	44127171	178623	None	0	Human	Functional	pEC50	=	5.6	5.6	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	421	11	4	6	2.5	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL466705	178623	None	0	Human	Functional	pEC50	=	5.6	5.6	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	421	11	4	6	2.5	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	10722793	113410	None	0	Human	Functional	pEC50	=	5.6	5.6	-407	3	In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.	ChEMBL	640	12	3	8	6.4	O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(OC(F)(F)F)cc3)cs2)cc1	10.1021/jm000286i
	CHEMBL331744	113410	None	0	Human	Functional	pEC50	=	5.6	5.6	-407	3	In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.	ChEMBL	640	12	3	8	6.4	O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(OC(F)(F)F)cc3)cs2)cc1	10.1021/jm000286i
	9871800	56504	None	0	Human	Functional	pEC50	=	5.6	5.6	-269	3	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	534	9	5	9	2.0	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(CC4SC(=O)NC4=O)cc3)CC2)ccc1O	10.1016/s0960-894x(01)00063-4
	CHEMBL163262	56504	None	0	Human	Functional	pEC50	=	5.6	5.6	-269	3	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	534	9	5	9	2.0	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(CC4SC(=O)NC4=O)cc3)CC2)ccc1O	10.1016/s0960-894x(01)00063-4
	46232974	203265	None	8	Human	Functional	pEC50	=	5.6	5.6	-27	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(CC(C)(C)NC[C@@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.12.087
	CHEMBL600817	203265	None	8	Human	Functional	pEC50	=	5.6	5.6	-27	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(CC(C)(C)NC[C@@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.12.087
	46233013	203761	None	0	Human	Functional	pEC50	=	6.6	6.6	-19	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1cccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmcl.2009.12.087
	CHEMBL604125	203761	None	0	Human	Functional	pEC50	=	6.6	6.6	-19	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1cccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmcl.2009.12.087
	45484538	14102	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	556	13	6	7	1.9	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL1197779	14102	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	556	13	6	7	1.9	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL585382	14102	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	556	13	6	7	1.9	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	44579651	187262	None	0	Human	Functional	pEC50	=	7.6	7.6	-14	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	425	9	3	4	5.1	C[C@H](Cc1cccc(Oc2cccc(C(=O)O)c2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2008.08.009
	CHEMBL492006	187262	None	0	Human	Functional	pEC50	=	7.6	7.6	-14	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	425	9	3	4	5.1	C[C@H](Cc1cccc(Oc2cccc(C(=O)O)c2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2008.08.009
	24894202	189133	None	0	Human	Functional	pEC50	=	7.6	7.6	-676	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	473	10	3	4	6.0	C[C@H](Cc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1)NC[C@H](O)c1ccccc1	10.1021/jm8000345
	CHEMBL509156	189133	None	0	Human	Functional	pEC50	=	7.6	7.6	-676	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	473	10	3	4	6.0	C[C@H](Cc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1)NC[C@H](O)c1ccccc1	10.1021/jm8000345
	44574688	178593	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	461	11	5	6	2.0	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]c(=O)[nH]c23)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL466519	178593	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	461	11	5	6	2.0	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]c(=O)[nH]c23)cc1	10.1016/j.bmc.2009.03.044
	44574722	178657	None	0	Human	Functional	pEC50	=	6.6	6.6	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	433	11	3	5	3.5	Cc1cc(C)nc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1	10.1016/j.bmc.2009.03.044
	CHEMBL466925	178657	None	0	Human	Functional	pEC50	=	6.6	6.6	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	433	11	3	5	3.5	Cc1cc(C)nc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1	10.1016/j.bmc.2009.03.044
	44219630	178680	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	498	13	2	6	3.7	CN(C(=O)Cc1nccn1Cc1ccccc1)c1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL467116	178680	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	498	13	2	6	3.7	CN(C(=O)Cc1nccn1Cc1ccccc1)c1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	24822310	97794	None	0	Human	Functional	pEC50	=	6.6	6.6	-41	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	395	8	3	3	4.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	CHEMBL271576	97794	None	0	Human	Functional	pEC50	=	6.6	6.6	-41	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	395	8	3	3	4.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	24822310	97794	None	0	Human	Functional	pEC50	=	6.6	6.6	-41	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	395	8	3	3	4.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2008.08.009
	CHEMBL271576	97794	None	0	Human	Functional	pEC50	=	6.6	6.6	-41	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	395	8	3	3	4.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2008.08.009
	44127054	197742	None	0	Human	Functional	pEC50	=	6.6	6.6	6	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	450	12	4	6	3.2	COc1ccc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL551350	197742	None	0	Human	Functional	pEC50	=	6.6	6.6	6	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	450	12	4	6	3.2	COc1ccc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.ejmech.2009.01.022
	24822310	97794	None	0	Human	Functional	pEC50	=	6.6	6.6	-41	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	395	8	3	3	4.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm800222k
	CHEMBL271576	97794	None	0	Human	Functional	pEC50	=	6.6	6.6	-41	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	395	8	3	3	4.6	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm800222k
	24895365	173696	None	0	Human	Functional	pEC50	=	6.6	6.6	-309	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	447	10	3	4	5.5	CC(C)Oc1cc(-c2ccc(CC(C)(C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL453323	173696	None	0	Human	Functional	pEC50	=	6.6	6.6	-309	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	447	10	3	4	5.5	CC(C)Oc1cc(-c2ccc(CC(C)(C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	10298968	57523	None	0	Human	Functional	pEC50	=	5.5	5.5	-239	2	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	471	9	4	8	2.3	O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)COc4ccc(O)cc4)CC3)cc2)S1	10.1016/s0960-894x(01)00063-4
	CHEMBL166085	57523	None	0	Human	Functional	pEC50	=	5.5	5.5	-239	2	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	471	9	4	8	2.3	O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)COc4ccc(O)cc4)CC3)cc2)S1	10.1016/s0960-894x(01)00063-4
	44396596	123367	None	0	Human	Functional	pEC50	=	7.5	7.5	-25	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	485	10	4	6	4.3	COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12	10.1016/j.bmcl.2004.10.035
	CHEMBL361505	123367	None	0	Human	Functional	pEC50	=	7.5	7.5	-25	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	485	10	4	6	4.3	COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12	10.1016/j.bmcl.2004.10.035
	44396521	123747	None	0	Human	Functional	pEC50	=	7.5	7.5	-6	2	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	514	12	5	7	3.6	C[C@H](Cc1c[nH]c2c(OCCN)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	CHEMBL362136	123747	None	0	Human	Functional	pEC50	=	7.5	7.5	-6	2	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	514	12	5	7	3.6	C[C@H](Cc1c[nH]c2c(OCCN)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	44127171	178623	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	421	11	4	6	2.5	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL466705	178623	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	421	11	4	6	2.5	O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.bmc.2009.03.044
	1028	291	None	40	Human	Functional	pEC50	=	6.5	6.5	-10	19	Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jnatprod.9b00418
	139148732	291	None	40	Human	Functional	pEC50	=	6.5	6.5	-10	19	Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jnatprod.9b00418
	479	291	None	40	Human	Functional	pEC50	=	6.5	6.5	-10	19	Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jnatprod.9b00418
	5816	291	None	40	Human	Functional	pEC50	=	6.5	6.5	-10	19	Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jnatprod.9b00418
	5816.0	291	None	40	Human	Functional	pEC50	=	6.5	6.5	-10	19	Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jnatprod.9b00418
	CHEMBL679	291	None	40	Human	Functional	pEC50	=	6.5	6.5	-10	19	Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jnatprod.9b00418
	DB00668	291	None	40	Human	Functional	pEC50	=	6.5	6.5	-10	19	Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jnatprod.9b00418
	45101537	197730	None	0	Human	Functional	pEC50	=	6.5	6.5	-1819	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	ChEMBL	526	11	4	7	3.8	CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccc(O)cc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1016/j.bmcl.2009.06.083
	CHEMBL551272	197730	None	0	Human	Functional	pEC50	=	6.5	6.5	-1819	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	ChEMBL	526	11	4	7	3.8	CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccc(O)cc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1016/j.bmcl.2009.06.083
	45483830	199451	None	0	Human	Functional	pEC50	=	6.5	6.5	-14	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	329	7	4	4	2.8	Cc1ccccc1CC(C)(C)NCC(O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2009.10.013
	CHEMBL566777	199451	None	0	Human	Functional	pEC50	=	6.5	6.5	-14	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	329	7	4	4	2.8	Cc1ccccc1CC(C)(C)NCC(O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2009.10.013
	44237720	58255	None	0	Rat	Functional	pEC50	=	6.5	6.5	-91	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	530	9	6	5	4.4	O=C(NCC12CC3CC(CC(C3)C1)C2)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682220	58255	None	0	Rat	Functional	pEC50	=	6.5	6.5	-91	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	530	9	6	5	4.4	O=C(NCC12CC3CC(CC(C3)C1)C2)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	145983355	165896	None	0	Human	Functional	pEC50	=	6.5	6.5	-26	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	454	12	3	5	3.6	CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NS(=O)(=O)c2ccccc2)cc1	10.1016/j.ejmech.2018.03.032
	CHEMBL4248093	165896	None	0	Human	Functional	pEC50	=	6.5	6.5	-26	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	454	12	3	5	3.6	CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NS(=O)(=O)c2ccccc2)cc1	10.1016/j.ejmech.2018.03.032
	44268273	97133	None	0	Human	Functional	pEC50	=	8.5	8.5	1	3	Agonist activity against cloned human beta-1 adrenergic receptor as percent activation of adenyl cyclase activity at a concentration of 1000 nMAgonist activity against cloned human beta-1 adrenergic receptor as percent activation of adenyl cyclase activity at a concentration of 1000 nM	ChEMBL	476	11	4	6	3.4	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1Cl	10.1016/s0960-894x(98)00169-3
	CHEMBL267306	97133	None	0	Human	Functional	pEC50	=	8.5	8.5	1	3	Agonist activity against cloned human beta-1 adrenergic receptor as percent activation of adenyl cyclase activity at a concentration of 1000 nMAgonist activity against cloned human beta-1 adrenergic receptor as percent activation of adenyl cyclase activity at a concentration of 1000 nM	ChEMBL	476	11	4	6	3.4	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1Cl	10.1016/s0960-894x(98)00169-3
	44392190	65604	None	0	Human	Functional	pEC50	=	8.5	8.5	4	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	421	10	5	5	3.2	O=C(Nc1ccccc1)Nc1ccc(C[C@H](O)NC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	CHEMBL183211	65604	None	0	Human	Functional	pEC50	=	8.5	8.5	4	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	421	10	5	5	3.2	O=C(Nc1ccccc1)Nc1ccc(C[C@H](O)NC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	9896742	207402	None	0	Human	Functional	pEC50	=	8.5	8.5	-13	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR) at a concentration of 10000 nmCompound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR) at a concentration of 10000 nm	ChEMBL	618	12	6	7	6.0	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc3cc(OCC4NCCc5cc(O)c(O)cc54)ccc3c2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL76403	207402	None	0	Human	Functional	pEC50	=	8.5	8.5	-13	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR) at a concentration of 10000 nmCompound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR) at a concentration of 10000 nm	ChEMBL	618	12	6	7	6.0	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc3cc(OCC4NCCc5cc(O)c(O)cc54)ccc3c2)cc1	10.1016/s0960-894x(00)00459-5
	66653268	88285	None	0	Human	Functional	pEC50	=	8.5	8.5	3311	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	491	14	4	6	3.8	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1cccc(Cl)c1	10.1021/jm400348g
	CHEMBL2348201	88285	None	0	Human	Functional	pEC50	=	8.5	8.5	3311	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	491	14	4	6	3.8	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1cccc(Cl)c1	10.1021/jm400348g
	164622954	188673	None	0	Human	Functional	pEC50	=	8.5	8.5	-245	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4871708	188673	None	0	Human	Functional	pEC50	=	8.5	8.5	-245	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028726	188673	None	0	Human	Functional	pEC50	=	8.5	8.5	-245	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164624634	188692	None	0	Human	Functional	pEC50	=	8.5	8.5	-131	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868684	188692	None	0	Human	Functional	pEC50	=	8.5	8.5	-131	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028836	188692	None	0	Human	Functional	pEC50	=	8.5	8.5	-131	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	24822971	95501	None	0	Human	Functional	pEC50	=	8.5	8.5	3	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	429	8	3	3	5.2	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2Cl)cc1	10.1021/jm701324c
	CHEMBL257106	95501	None	0	Human	Functional	pEC50	=	8.5	8.5	3	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	429	8	3	3	5.2	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2Cl)cc1	10.1021/jm701324c
	11134054	46997	None	0	Human	Functional	pEC50	=	8.5	8.5	-2	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	444	10	4	6	4.1	C[C@H](CNc1ccc(CC(=O)Nc2nccs2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL154150	46997	None	0	Human	Functional	pEC50	=	8.5	8.5	-2	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	444	10	4	6	4.1	C[C@H](CNc1ccc(CC(=O)Nc2nccs2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	1499	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	1499	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	3779	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	3779	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	536	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	536	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.5	8.5	-58	38	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	45484583	200948	None	0	Human	Functional	pEC50	=	8.5	8.5	-3	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	456	10	6	7	2.0	CC(C)(Cc1ccc(NC(=O)CCCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL577702	200948	None	0	Human	Functional	pEC50	=	8.5	8.5	-3	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	456	10	6	7	2.0	CC(C)(Cc1ccc(NC(=O)CCCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	45484585	14103	None	0	Human	Functional	pEC50	=	8.5	8.5	-3	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	556	13	6	7	1.9	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL1197807	14103	None	0	Human	Functional	pEC50	=	8.5	8.5	-3	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	556	13	6	7	1.9	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL587197	14103	None	0	Human	Functional	pEC50	=	8.5	8.5	-3	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	556	13	6	7	1.9	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	24936626	17416	None	0	Human	Functional	pEC50	=	8.5	8.5	-173	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	506	9	4	9	3.6	OCc1cc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)ccc1O	10.1016/j.bmcl.2010.08.039
	CHEMBL1257555	17416	None	0	Human	Functional	pEC50	=	8.5	8.5	-173	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	506	9	4	9	3.6	OCc1cc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)ccc1O	10.1016/j.bmcl.2010.08.039
	45483814	199728	None	0	Human	Functional	pEC50	=	8.4	8.4	-5	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	440	7	4	6	3.3	CC(C)(Cc1ccc(OC(F)(F)F)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL568531	199728	None	0	Human	Functional	pEC50	=	8.4	8.4	-5	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	440	7	4	6	3.3	CC(C)(Cc1ccc(OC(F)(F)F)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	44392212	168472	None	0	Human	Functional	pEC50	=	8.4	8.4	12	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	405	10	4	4	3.9	O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	CHEMBL1204383	168472	None	0	Human	Functional	pEC50	=	8.4	8.4	12	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	405	10	4	4	3.9	O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	CHEMBL434524	168472	None	0	Human	Functional	pEC50	=	8.4	8.4	12	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	405	10	4	4	3.9	O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	56597179	88303	None	0	Human	Functional	pEC50	=	8.4	8.4	2754	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	473	14	5	7	2.9	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	CHEMBL2348219	88303	None	0	Human	Functional	pEC50	=	8.4	8.4	2754	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	473	14	5	7	2.9	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	45483868	199678	None	0	Human	Functional	pEC50	=	8.4	8.4	-6	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	424	6	4	5	3.4	CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL568273	199678	None	0	Human	Functional	pEC50	=	8.4	8.4	-6	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	424	6	4	5	3.4	CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	45483864	201365	None	0	Human	Functional	pEC50	=	8.4	8.4	-9	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	424	6	4	5	3.4	CC(C)(Cc1ccc(C(F)(F)F)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL584498	201365	None	0	Human	Functional	pEC50	=	8.4	8.4	-9	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	424	6	4	5	3.4	CC(C)(Cc1ccc(C(F)(F)F)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	24823624	159254	None	0	Human	Functional	pEC50	=	8.4	8.4	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	410	9	4	4	4.6	O=C(O)c1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	CHEMBL409827	159254	None	0	Human	Functional	pEC50	=	8.4	8.4	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	410	9	4	4	4.6	O=C(O)c1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	16049028	64106	None	0	Human	Functional	pEC50	=	8.4	8.4	-50	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	462	14	4	7	3.7	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807819	64106	None	0	Human	Functional	pEC50	=	8.4	8.4	-50	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	462	14	4	7	3.7	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	11592062	112520	None	0	Human	Functional	pEC50	=	8.4	8.4	-25	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298325	112520	None	0	Human	Functional	pEC50	=	8.4	8.4	-25	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1	10.1016/j.bmcl.2014.04.095
	24822645	95546	None	0	Human	Functional	pEC50	=	7.5	7.5	-15	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	429	8	3	3	5.2	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c(Cl)c1	10.1021/jm701324c
	CHEMBL257297	95546	None	0	Human	Functional	pEC50	=	7.5	7.5	-15	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	429	8	3	3	5.2	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c(Cl)c1	10.1021/jm701324c
	45269866	197750	None	0	Human	Functional	pEC50	=	7.5	7.5	1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Cl)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL2448072	197750	None	0	Human	Functional	pEC50	=	7.5	7.5	1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Cl)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL551389	197750	None	0	Human	Functional	pEC50	=	7.5	7.5	1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Cl)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	45269025	198603	None	0	Human	Functional	pEC50	=	7.5	7.5	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	500	11	5	6	2.7	NS(=O)(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203991	198603	None	0	Human	Functional	pEC50	=	7.5	7.5	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	500	11	5	6	2.7	NS(=O)(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL561173	198603	None	0	Human	Functional	pEC50	=	7.5	7.5	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	500	11	5	6	2.7	NS(=O)(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	45267257	199138	None	0	Human	Functional	pEC50	=	7.5	7.5	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	449	12	4	4	3.8	O[C@@H](CNCCc1ccc(NC(=S)NCCc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203987	199138	None	0	Human	Functional	pEC50	=	7.5	7.5	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	449	12	4	4	3.8	O[C@@H](CNCCc1ccc(NC(=S)NCCc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL564648	199138	None	0	Human	Functional	pEC50	=	7.5	7.5	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	449	12	4	4	3.8	O[C@@H](CNCCc1ccc(NC(=S)NCCc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	10283146	107329	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	656	12	5	9	3.1	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4cc(CC(=O)O)c5ccccc54)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	CHEMBL317003	107329	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	656	12	5	9	3.1	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4cc(CC(=O)O)c5ccccc54)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	1960	2857	None	46	Guinea pig	Functional	pEC50	=	7.5	7.5	-37	18	Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	439260	2857	None	46	Guinea pig	Functional	pEC50	=	7.5	7.5	-37	18	Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	439260.0	2857	None	46	Guinea pig	Functional	pEC50	=	7.5	7.5	-37	18	Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	505	2857	None	46	Guinea pig	Functional	pEC50	=	7.5	7.5	-37	18	Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	CHEMBL1437	2857	None	46	Guinea pig	Functional	pEC50	=	7.5	7.5	-37	18	Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	DB00368	2857	None	46	Guinea pig	Functional	pEC50	=	7.5	7.5	-37	18	Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	164623583	188683	None	0	Human	Functional	pEC50	=	7.5	7.5	-316	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4873280	188683	None	0	Human	Functional	pEC50	=	7.5	7.5	-316	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028767	188683	None	0	Human	Functional	pEC50	=	7.5	7.5	-316	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	24822970	158212	None	0	Human	Functional	pEC50	=	6.5	6.5	-9	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	409	9	3	3	4.5	O=C(O)Cc1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	CHEMBL408694	158212	None	0	Human	Functional	pEC50	=	6.5	6.5	-9	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	409	9	3	3	4.5	O=C(O)Cc1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	11224220	173070	None	0	Human	Functional	pEC50	=	6.5	6.5	-2137	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	431	10	3	3	5.5	CC(C)Cc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL451760	173070	None	0	Human	Functional	pEC50	=	6.5	6.5	-2137	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	431	10	3	3	5.5	CC(C)Cc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	172745	100177	None	2	Guinea pig	Functional	pEC50	=	6.5	6.5	234	2	Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations	ChEMBL	187	2	4	4	0.2	NCC(O)c1ccc(O)c(O)c1F	10.1021/jm00118a019
	CHEMBL287587	100177	None	2	Guinea pig	Functional	pEC50	=	6.5	6.5	234	2	Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations	ChEMBL	187	2	4	4	0.2	NCC(O)c1ccc(O)c(O)c1F	10.1021/jm00118a019
	44268268	18658	None	1	Human	Functional	pEC50	=	6.5	6.5	-301	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	493	11	4	7	3.3	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1cnc2ccccc2c1	10.1016/s0960-894x(98)00169-3
	CHEMBL12769	18658	None	1	Human	Functional	pEC50	=	6.5	6.5	-301	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	493	11	4	7	3.3	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1cnc2ccccc2c1	10.1016/s0960-894x(98)00169-3
	172462257	196705	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	3	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	459	10	2	5	5.0	CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1	10.1016/j.ejmech.2022.114961
	CHEMBL5430355	196705	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	3	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	459	10	2	5	5.0	CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1	10.1016/j.ejmech.2022.114961
	172446785	195127	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	3	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	389	11	2	3	4.8	CCc1ccccc1OC[C@@H](O)CNCCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2022.114961
	CHEMBL5397120	195127	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	3	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	389	11	2	3	4.8	CCc1ccccc1OC[C@@H](O)CNCCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2022.114961
	16049377	64119	None	0	Human	Functional	pEC50	=	7.5	7.5	-112	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	465	13	5	7	2.8	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCOCCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807832	64119	None	0	Human	Functional	pEC50	=	7.5	7.5	-112	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	465	13	5	7	2.8	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCOCCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	56665368	66480	None	0	Human	Functional	pEC50	=	7.5	7.5	-31	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	501	18	6	6	4.2	CCNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835854	66480	None	0	Human	Functional	pEC50	=	7.5	7.5	-31	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	501	18	6	6	4.2	CCNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852119	66480	None	0	Human	Functional	pEC50	=	7.5	7.5	-31	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	501	18	6	6	4.2	CCNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	56672271	66562	None	0	Human	Functional	pEC50	=	7.5	7.5	-125	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835859	66562	None	0	Human	Functional	pEC50	=	7.5	7.5	-125	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852407	66562	None	0	Human	Functional	pEC50	=	7.5	7.5	-125	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	56672269	66608	None	0	Human	Functional	pEC50	=	7.5	7.5	-50	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	515	19	6	6	3.9	CCNC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835858	66608	None	0	Human	Functional	pEC50	=	7.5	7.5	-50	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	515	19	6	6	3.9	CCNC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852564	66608	None	0	Human	Functional	pEC50	=	7.5	7.5	-50	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	515	19	6	6	3.9	CCNC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	56658405	66609	None	0	Human	Functional	pEC50	=	7.5	7.5	-63	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	501	18	6	6	4.2	CCNC(=O)Nc1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1016/j.bmc.2011.08.043
	CHEMBL1835856	66609	None	0	Human	Functional	pEC50	=	7.5	7.5	-63	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	501	18	6	6	4.2	CCNC(=O)Nc1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1016/j.bmc.2011.08.043
	CHEMBL1852565	66609	None	0	Human	Functional	pEC50	=	7.5	7.5	-63	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	501	18	6	6	4.2	CCNC(=O)Nc1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1016/j.bmc.2011.08.043
	46832505	14240	None	1	Human	Functional	pEC50	=	7.5	7.5	-12	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	417	16	4	6	3.3	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2ccccc2)ccc1O	10.1021/jm100326d
	CHEMBL1085395	14240	None	1	Human	Functional	pEC50	=	7.5	7.5	-12	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	417	16	4	6	3.3	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2ccccc2)ccc1O	10.1021/jm100326d
	CHEMBL1199261	14240	None	1	Human	Functional	pEC50	=	7.5	7.5	-12	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	417	16	4	6	3.3	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2ccccc2)ccc1O	10.1021/jm100326d
	46889854	7310	None	0	Human	Functional	pEC50	=	6.5	6.5	-9	3	Agonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayAgonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assay	ChEMBL	446	7	2	4	4.8	O=C(c1ccc(F)cc1)C1CCN(CC(O)COc2cccc3[nH]c4ccccc4c23)CC1	10.1016/j.bmcl.2010.04.009
	CHEMBL1086077	7310	None	0	Human	Functional	pEC50	=	6.5	6.5	-9	3	Agonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayAgonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assay	ChEMBL	446	7	2	4	4.8	O=C(c1ccc(F)cc1)C1CCN(CC(O)COc2cccc3[nH]c4ccccc4c23)CC1	10.1016/j.bmcl.2010.04.009
	24949728	175344	None	0	Human	Functional	pEC50	=	6.5	6.5	-436	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	479	8	3	4	5.7	CC(C)Oc1cc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)ccc1C(=O)O	10.1021/jm800222k
	CHEMBL457199	175344	None	0	Human	Functional	pEC50	=	6.5	6.5	-436	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	479	8	3	4	5.7	CC(C)Oc1cc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)ccc1C(=O)O	10.1021/jm800222k
	44127679	197918	None	0	Human	Functional	pEC50	=	5.5	5.5	-37	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	422	11	4	7	1.9	O=C(Cc1cnccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL552497	197918	None	0	Human	Functional	pEC50	=	5.5	5.5	-37	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	422	11	4	7	1.9	O=C(Cc1cnccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	172454272	196013	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	359	7	2	7	1.6	O[C@@H](CNCC1COc2ccccc2O1)COc1ccc2c(c1)OCO2	10.1016/j.ejmech.2022.114961
	CHEMBL5415148	196013	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	359	7	2	7	1.6	O[C@@H](CNCC1COc2ccccc2O1)COc1ccc2c(c1)OCO2	10.1016/j.ejmech.2022.114961
	9891927	184303	None	9	Human	Functional	pEC50	=	6.5	6.5	-1995	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL446840	184303	None	9	Human	Functional	pEC50	=	6.5	6.5	-1995	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483200	184303	None	9	Human	Functional	pEC50	=	6.5	6.5	-1995	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483201	184303	None	9	Human	Functional	pEC50	=	6.5	6.5	-1995	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	9891927	184303	None	9	Human	Functional	pEC50	=	6.5	6.5	-1995	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL446840	184303	None	9	Human	Functional	pEC50	=	6.5	6.5	-1995	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL483200	184303	None	9	Human	Functional	pEC50	=	6.5	6.5	-1995	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL483201	184303	None	9	Human	Functional	pEC50	=	6.5	6.5	-1995	4	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	44331302	210787	None	0	Human	Functional	pEC50	=	5.5	5.5	-630	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	667	12	6	8	3.1	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	CHEMBL99219	210787	None	0	Human	Functional	pEC50	=	5.5	5.5	-630	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	667	12	6	8	3.1	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	11661536	76003	None	0	Human	Functional	pEC50	=	5.5	5.5	-50	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	411	9	4	5	3.8	O=C(O)c1cncc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)c1	10.1021/jm0509445
	CHEMBL205389	76003	None	0	Human	Functional	pEC50	=	5.5	5.5	-50	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	411	9	4	5	3.8	O=C(O)c1cncc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)c1	10.1021/jm0509445
	145987415	167344	None	0	Human	Functional	pEC50	=	5.5	5.5	-1258	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	358	6	4	4	2.8	O=c1ccc2c(C(CO)NCCc3cccc(Cl)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2018.04.041
	CHEMBL4292648	167344	None	0	Human	Functional	pEC50	=	5.5	5.5	-1258	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	358	6	4	4	2.8	O=c1ccc2c(C(CO)NCCc3cccc(Cl)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2018.04.041
	24895192	189973	None	0	Human	Functional	pEC50	=	6.5	6.5	-151	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	437	10	3	4	4.8	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(F)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL516804	189973	None	0	Human	Functional	pEC50	=	6.5	6.5	-151	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	437	10	3	4	4.8	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(F)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	42639969	12576	None	0	Human	Functional	pEC50	=	6.5	6.5	-1584	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	496	11	4	7	3.1	CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL1186809	12576	None	0	Human	Functional	pEC50	=	6.5	6.5	-1584	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	496	11	4	7	3.1	CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL479530	12576	None	0	Human	Functional	pEC50	=	6.5	6.5	-1584	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	496	11	4	7	3.1	CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	16118894	2243	None	7	Human	Functional	pEC50	=	6.5	6.5	-147	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	568	11	4	6	3.4	O[C@H](COc1ccc(cc1)O)CNCCc1ccc(cc1)NS(=O)(=O)c1ccc(cc1)I	10.1016/s0960-894x(98)00169-3
	3467	2243	None	7	Human	Functional	pEC50	=	6.5	6.5	-147	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	568	11	4	6	3.4	O[C@H](COc1ccc(cc1)O)CNCCc1ccc(cc1)NS(=O)(=O)c1ccc(cc1)I	10.1016/s0960-894x(98)00169-3
	CHEMBL276257	2243	None	7	Human	Functional	pEC50	=	6.5	6.5	-147	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	568	11	4	6	3.4	O[C@H](COc1ccc(cc1)O)CNCCc1ccc(cc1)NS(=O)(=O)c1ccc(cc1)I	10.1016/s0960-894x(98)00169-3
	45483815	200898	None	0	Human	Functional	pEC50	=	7.5	7.5	-11	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	400	7	5	6	2.1	CC(C)(Cc1ccc(C(=O)O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL577289	200898	None	0	Human	Functional	pEC50	=	7.5	7.5	-11	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	400	7	5	6	2.1	CC(C)(Cc1ccc(C(=O)O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	44574721	178656	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	419	11	3	5	3.1	Cc1cccnc1CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL466924	178656	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	419	11	3	5	3.1	Cc1cccnc1CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	24950238	175058	None	0	Human	Functional	pEC50	=	6.5	6.5	-69	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	437	7	3	4	5.0	O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)c1	10.1021/jm800222k
	CHEMBL456578	175058	None	0	Human	Functional	pEC50	=	6.5	6.5	-69	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	437	7	3	4	5.0	O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)c1	10.1021/jm800222k
	45270697	197626	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	451	11	4	5	4.1	COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203995	197626	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	451	11	4	5	4.1	COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL550444	197626	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	451	11	4	5	4.1	COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	24949568	189792	None	0	Human	Functional	pEC50	=	6.5	6.5	-338	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	536	9	4	6	5.6	O=C(O)c1cc(NC2CCOCC2)cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)c1	10.1021/jm800222k
	CHEMBL515349	189792	None	0	Human	Functional	pEC50	=	6.5	6.5	-338	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	536	9	4	6	5.6	O=C(O)c1cc(NC2CCOCC2)cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)c1	10.1021/jm800222k
	10075383	97158	None	0	Human	Functional	pEC50	=	6.5	6.5	-537	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	520	11	4	6	3.5	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccc(Br)cc1	10.1016/s0960-894x(98)00169-3
	CHEMBL267545	97158	None	0	Human	Functional	pEC50	=	6.5	6.5	-537	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	520	11	4	6	3.5	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccc(Br)cc1	10.1016/s0960-894x(98)00169-3
	46232768	202090	None	0	Human	Functional	pEC50	=	7.5	7.5	-14	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	356	6	4	5	2.4	CC(C)(Cc1ccccc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL592879	202090	None	0	Human	Functional	pEC50	=	7.5	7.5	-14	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	356	6	4	5	2.4	CC(C)(Cc1ccccc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	164624092	188688	None	0	Human	Functional	pEC50	=	7.5	7.5	-794	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	442	10	4	7	2.9	COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL4865514	188688	None	0	Human	Functional	pEC50	=	7.5	7.5	-794	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	442	10	4	7	2.9	COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL5028807	188688	None	0	Human	Functional	pEC50	=	7.5	7.5	-794	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	442	10	4	7	2.9	COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	145986105	165465	None	0	Human	Functional	pEC50	=	7.4	7.4	-25	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	429	10	4	4	4.0	O=C(Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1)c1ccccc1	10.1016/j.ejmech.2018.03.032
	CHEMBL4237453	165465	None	0	Human	Functional	pEC50	=	7.4	7.4	-25	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	429	10	4	4	4.0	O=C(Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1)c1ccccc1	10.1016/j.ejmech.2018.03.032
	44219641	178544	None	0	Human	Functional	pEC50	=	6.5	6.5	-5	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	498	13	3	6	4.1	CC(Cc1ccc(NC(=O)Cc2nccn2Cc2ccccc2)cc1)NC[C@H](O)COc1ccccc1	10.1016/j.bmc.2009.03.044
	CHEMBL466088	178544	None	0	Human	Functional	pEC50	=	6.5	6.5	-5	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	498	13	3	6	4.1	CC(Cc1ccc(NC(=O)Cc2nccn2Cc2ccccc2)cc1)NC[C@H](O)COc1ccccc1	10.1016/j.bmc.2009.03.044
	24822815	97995	None	0	Human	Functional	pEC50	=	6.5	6.5	-588	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	467	11	3	4	5.6	CC(C)COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm701324c
	CHEMBL272583	97995	None	0	Human	Functional	pEC50	=	6.5	6.5	-588	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	467	11	3	4	5.6	CC(C)COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm701324c
	44127678	198758	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	471	11	4	6	3.7	O=C(Cc1cc2ccccc2cn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL562153	198758	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	471	11	4	6	3.7	O=C(Cc1cc2ccccc2cn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	1960	2857	None	46	Guinea pig	Functional	pEC50	=	6.5	6.5	-37	18	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	439260	2857	None	46	Guinea pig	Functional	pEC50	=	6.5	6.5	-37	18	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	439260.0	2857	None	46	Guinea pig	Functional	pEC50	=	6.5	6.5	-37	18	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	505	2857	None	46	Guinea pig	Functional	pEC50	=	6.5	6.5	-37	18	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	CHEMBL1437	2857	None	46	Guinea pig	Functional	pEC50	=	6.5	6.5	-37	18	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	DB00368	2857	None	46	Guinea pig	Functional	pEC50	=	6.5	6.5	-37	18	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	10275157	5379	None	0	Human	Functional	pEC50	=	6.5	6.5	-7	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	442	10	5	6	2.2	CNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL107012	5379	None	0	Human	Functional	pEC50	=	6.5	6.5	-7	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	442	10	5	6	2.2	CNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	10283539	167968	None	0	Human	Functional	pEC50	=	6.5	6.5	-1479	3	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	697	14	6	9	2.8	CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00607-8
	CHEMBL431048	167968	None	0	Human	Functional	pEC50	=	6.5	6.5	-1479	3	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	697	14	6	9	2.8	CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00607-8
	9800339	203610	None	9	Human	Functional	pEC50	=	6.5	6.5	-251	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.12.087
	CHEMBL603271	203610	None	9	Human	Functional	pEC50	=	6.5	6.5	-251	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.12.087
	24823626	98099	None	0	Human	Functional	pEC50	=	7.4	7.4	-6	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	410	9	4	4	4.6	O=C(O)c1cccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c1	10.1021/jm701324c
	CHEMBL273098	98099	None	0	Human	Functional	pEC50	=	7.4	7.4	-6	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	410	9	4	4	4.6	O=C(O)c1cccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c1	10.1021/jm701324c
	155557083	174645	None	0	Human	Functional	pEC50	=	7.4	7.4	-724	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccc(O)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4556022	174645	None	0	Human	Functional	pEC50	=	7.4	7.4	-724	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccc(O)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	145982607	165815	None	0	Human	Functional	pEC50	=	7.4	7.4	-4	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	432	12	3	4	4.0	CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=O)Cc2ccccc2)cc1	10.1016/j.ejmech.2018.03.032
	CHEMBL4245968	165815	None	0	Human	Functional	pEC50	=	7.4	7.4	-4	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	432	12	3	4	4.0	CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=O)Cc2ccccc2)cc1	10.1016/j.ejmech.2018.03.032
	24949566	174976	None	1	Human	Functional	pEC50	=	6.4	6.4	-281	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	494	8	4	5	5.0	CC(=O)Nc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1	10.1021/jm800222k
	CHEMBL456353	174976	None	1	Human	Functional	pEC50	=	6.4	6.4	-281	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	494	8	4	5	5.0	CC(=O)Nc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1	10.1021/jm800222k
	1862	161	None	11	Guinea pig	Functional	pEC50	=	4.4	4.4	-9	2	Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations	ChEMBL	187	2	4	4	0.2	NCC(c1cc(O)c(cc1F)O)O	10.1021/jm00118a019
	510	161	None	11	Guinea pig	Functional	pEC50	=	4.4	4.4	-9	2	Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations	ChEMBL	187	2	4	4	0.2	NCC(c1cc(O)c(cc1F)O)O	10.1021/jm00118a019
	CHEMBL281232	161	None	11	Guinea pig	Functional	pEC50	=	4.4	4.4	-9	2	Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations	ChEMBL	187	2	4	4	0.2	NCC(c1cc(O)c(cc1F)O)O	10.1021/jm00118a019
	24824079	12898	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	441	11	3	5	4.5	O=C(O)COc1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	CHEMBL1188934	12898	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	441	11	3	5	4.5	O=C(O)COc1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	CHEMBL537693	12898	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	441	11	3	5	4.5	O=C(O)COc1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	24895357	186401	None	0	Human	Functional	pEC50	=	7.4	7.4	-194	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	467	10	3	4	5.7	CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL487443	186401	None	0	Human	Functional	pEC50	=	7.4	7.4	-194	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	467	10	3	4	5.7	CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	42639965	12722	None	0	Human	Functional	pEC50	=	6.4	6.4	-691	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	534	11	3	5	5.0	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1CC1CCCCC1	10.1021/jm9000709
	CHEMBL1187643	12722	None	0	Human	Functional	pEC50	=	6.4	6.4	-691	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	534	11	3	5	5.0	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1CC1CCCCC1	10.1021/jm9000709
	CHEMBL513419	12722	None	0	Human	Functional	pEC50	=	6.4	6.4	-691	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	534	11	3	5	5.0	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1CC1CCCCC1	10.1021/jm9000709
	44457929	84811	None	0	Human	Functional	pEC50	=	6.4	6.4	-114	3	Agonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclaseAgonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase	ChEMBL	593	17	3	10	3.9	CCCCCCCCn1nnn(-c2ccc(S(=O)(=O)Nc3ccc(CCNC[C@H](O)c4cccnc4)cc3)cc2)c1=O	10.1016/s0960-894x(99)00182-1
	CHEMBL22318	84811	None	0	Human	Functional	pEC50	=	6.4	6.4	-114	3	Agonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclaseAgonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase	ChEMBL	593	17	3	10	3.9	CCCCCCCCn1nnn(-c2ccc(S(=O)(=O)Nc3ccc(CCNC[C@H](O)c4cccnc4)cc3)cc2)c1=O	10.1016/s0960-894x(99)00182-1
	2419	3463	None	53	Human	Functional	pEC50	=	6.4	6.4	-977	19	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	5152	3463	None	53	Human	Functional	pEC50	=	6.4	6.4	-977	19	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	5152.0	3463	None	53	Human	Functional	pEC50	=	6.4	6.4	-977	19	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	559	3463	None	53	Human	Functional	pEC50	=	6.4	6.4	-977	19	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	6.4	6.4	-977	19	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	DB00938	3463	None	53	Human	Functional	pEC50	=	6.4	6.4	-977	19	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	24823130	97757	None	0	Human	Functional	pEC50	=	6.4	6.4	-38	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	413	8	3	3	4.7	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1F	10.1021/jm701324c
	CHEMBL271367	97757	None	0	Human	Functional	pEC50	=	6.4	6.4	-38	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	413	8	3	3	4.7	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1F	10.1021/jm701324c
	44580011	186906	None	0	Human	Functional	pEC50	=	6.4	6.4	-52	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	468	10	4	5	4.7	CC(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	CHEMBL489200	186906	None	0	Human	Functional	pEC50	=	6.4	6.4	-52	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	468	10	4	5	4.7	CC(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	10028830	2246	None	31	Human	Functional	pEC50	=	6.4	6.4	-186	3	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	497	13	4	6	2.7	O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1	10.1016/j.ejmech.2022.114961
	3932	2246	None	31	Human	Functional	pEC50	=	6.4	6.4	-186	3	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	497	13	4	6	2.7	O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1	10.1016/j.ejmech.2022.114961
	CHEMBL4238084	2246	None	31	Human	Functional	pEC50	=	6.4	6.4	-186	3	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	497	13	4	6	2.7	O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1	10.1016/j.ejmech.2022.114961
	9997789	186407	None	1	Human	Functional	pEC50	=	5.4	5.4	-107	2	Agonist activity at beta1 adrenoceptor (unknown origin)Agonist activity at beta1 adrenoceptor (unknown origin)	ChEMBL	310	3	3	3	3.4	CC(C)(C)NC(CO)c1cc(Cl)c(N)c(C(F)(F)F)c1	10.1021/acs.jmedchem.0c01195
	CHEMBL4874511	186407	None	1	Human	Functional	pEC50	=	5.4	5.4	-107	2	Agonist activity at beta1 adrenoceptor (unknown origin)Agonist activity at beta1 adrenoceptor (unknown origin)	ChEMBL	310	3	3	3	3.4	CC(C)(C)NC(CO)c1cc(Cl)c(N)c(C(F)(F)F)c1	10.1021/acs.jmedchem.0c01195
	CHEMBL5192245	186407	None	1	Human	Functional	pEC50	=	5.4	5.4	-107	2	Agonist activity at beta1 adrenoceptor (unknown origin)Agonist activity at beta1 adrenoceptor (unknown origin)	ChEMBL	310	3	3	3	3.4	CC(C)(C)NC(CO)c1cc(Cl)c(N)c(C(F)(F)F)c1	10.1021/acs.jmedchem.0c01195
	24895263	194658	None	0	Human	Functional	pEC50	=	7.4	7.4	-1122	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	475	10	4	6	4.6	Nc1ccc([C@@H](O)CNCCc2ccc(-c3ccc(C(=O)O)c(OC4CCCCC4)c3)cc2)cn1	10.1021/jm8000345
	CHEMBL529659	194658	None	0	Human	Functional	pEC50	=	7.4	7.4	-1122	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	475	10	4	6	4.6	Nc1ccc([C@@H](O)CNCCc2ccc(-c3ccc(C(=O)O)c(OC4CCCCC4)c3)cc2)cn1	10.1021/jm8000345
	44591508	179101	None	0	Human	Functional	pEC50	=	7.4	7.4	-1122	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	475	10	4	6	4.6	Nc1ccncc1[C@@H](O)CNCCc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1	10.1021/jm9000709
	CHEMBL470857	179101	None	0	Human	Functional	pEC50	=	7.4	7.4	-1122	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	475	10	4	6	4.6	Nc1ccncc1[C@@H](O)CNCCc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1	10.1021/jm9000709
	319	1324	None	32	Human	Functional	pEC50	=	7.4	7.4	-43	18	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2011.05.097
	321	1324	None	32	Human	Functional	pEC50	=	7.4	7.4	-43	18	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2011.05.097
	444031	1324	None	32	Human	Functional	pEC50	=	7.4	7.4	-43	18	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2011.05.097
	444031.0	1324	None	32	Human	Functional	pEC50	=	7.4	7.4	-43	18	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2011.05.097
	784	1324	None	32	Human	Functional	pEC50	=	7.4	7.4	-43	18	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2011.05.097
	CHEMBL1346	1324	None	32	Human	Functional	pEC50	=	7.4	7.4	-43	18	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2011.05.097
	DB00496	1324	None	32	Human	Functional	pEC50	=	7.4	7.4	-43	18	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2011.05.097
	56670158	64117	None	0	Human	Functional	pEC50	=	7.4	7.4	-15	2	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	497	13	5	7	2.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCC[S+]([O-])CCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807830	64117	None	0	Human	Functional	pEC50	=	7.4	7.4	-15	2	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	497	13	5	7	2.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCC[S+]([O-])CCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	16049309	64121	None	0	Human	Functional	pEC50	=	7.4	7.4	-100	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3ccccc3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807870	64121	None	0	Human	Functional	pEC50	=	7.4	7.4	-100	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3ccccc3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	56663238	64123	None	0	Human	Functional	pEC50	=	7.4	7.4	-251	2	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	465	13	5	7	2.8	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807872	64123	None	0	Human	Functional	pEC50	=	7.4	7.4	-251	2	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	465	13	5	7	2.8	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	1239	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	3410	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	3410.0	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	3465	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	CHEMBL1256786	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	DB00983	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	3083544	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmc.2011.08.043
	3083544.0	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmc.2011.08.043
	CHEMBL1200811	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmc.2011.08.043
	CHEMBL1363	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmc.2011.08.043
	CHEMBL1951071	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmc.2011.08.043
	CHEMBL605993	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmc.2011.08.043
	DB00983	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmc.2011.08.043
	DB01274	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmc.2011.08.043
	10288976	66601	None	0	Human	Functional	pEC50	=	7.4	7.4	-251	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	17	6	6	3.9	Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835862	66601	None	0	Human	Functional	pEC50	=	7.4	7.4	-251	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	17	6	6	3.9	Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852543	66601	None	0	Human	Functional	pEC50	=	7.4	7.4	-251	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	17	6	6	3.9	Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1	10.1016/j.bmc.2011.08.043
	1239	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	3410	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	3410.0	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	3465	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	CHEMBL1256786	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	DB00983	1677	None	37	Human	Functional	pEC50	=	7.4	7.4	-67	6	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	3083544	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/jm100326d
	3083544.0	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/jm100326d
	CHEMBL1200811	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/jm100326d
	CHEMBL1363	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/jm100326d
	CHEMBL1951071	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/jm100326d
	CHEMBL605993	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/jm100326d
	DB00983	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/jm100326d
	DB01274	26817	None	34	Human	Functional	pEC50	=	7.4	7.4	-199	6	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/jm100326d
	49861320	54982	None	0	Human	Functional	pEC50	=	6.4	6.4	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	426	11	3	5	3.1	O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204003	54982	None	0	Human	Functional	pEC50	=	6.4	6.4	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	426	11	3	5	3.1	O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1615579	54982	None	0	Human	Functional	pEC50	=	6.4	6.4	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	426	11	3	5	3.1	O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	44565932	187117	None	0	Human	Functional	pEC50	=	6.4	6.4	-4897	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	528	11	4	8	3.4	CC(C)Sc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL490733	187117	None	0	Human	Functional	pEC50	=	6.4	6.4	-4897	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	528	11	4	8	3.4	CC(C)Sc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	10305108	111506	None	0	Human	Functional	pEC50	=	6.4	6.4	-77	3	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	659	17	6	8	4.2	CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)c4c3CCC(=O)N4)CC2)cc1	10.1016/s0960-894x(02)00607-8
	CHEMBL327519	111506	None	0	Human	Functional	pEC50	=	6.4	6.4	-77	3	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	659	17	6	8	4.2	CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)c4c3CCC(=O)N4)CC2)cc1	10.1016/s0960-894x(02)00607-8
	44441233	148144	None	0	Human	Functional	pEC50	=	6.4	6.4	-100	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	9	4	6	3.8	C[C@H](CNc1cccc(-c2ocnc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL393471	148144	None	0	Human	Functional	pEC50	=	6.4	6.4	-100	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	9	4	6	3.8	C[C@H](CNc1cccc(-c2ocnc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	10184665	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1016/j.bmc.2011.08.043
	10184665.0	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1016/j.bmc.2011.08.043
	4799	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1016/j.bmc.2011.08.043
	7353	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1016/j.bmc.2011.08.043
	CHEMBL1198857	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1016/j.bmc.2011.08.043
	DB09082	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1016/j.bmc.2011.08.043
	10184665	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1021/jm100326d
	10184665.0	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1021/jm100326d
	4799	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1021/jm100326d
	7353	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1021/jm100326d
	CHEMBL1198857	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1021/jm100326d
	DB09082	3991	None	42	Human	Functional	pEC50	=	6.4	6.4	-173	10	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1021/jm100326d
	11038599	47882	None	0	Human	Functional	pEC50	=	6.4	6.4	-25	3	Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	516	11	5	6	3.7	C[C@H](CNc1cccc(CNC(=O)NS(=O)(=O)c2ccccc2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL154906	47882	None	0	Human	Functional	pEC50	=	6.4	6.4	-25	3	Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	516	11	5	6	3.7	C[C@H](CNc1cccc(CNC(=O)NS(=O)(=O)c2ccccc2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	9512	3636	None	34	Human	Functional	pEC50	=	5.4	5.4	-1202	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	410	9	4	4	4.4	Clc1cccc(c1)[C@H](CNCCNc1cccc(c1)c1cccc(c1)C(=O)O)O	10.1021/jm0509445
	9887812	3636	None	34	Human	Functional	pEC50	=	5.4	5.4	-1202	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	410	9	4	4	4.4	Clc1cccc(c1)[C@H](CNCCNc1cccc(c1)c1cccc(c1)C(=O)O)O	10.1021/jm0509445
	CHEMBL208427	3636	None	34	Human	Functional	pEC50	=	5.4	5.4	-1202	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	410	9	4	4	4.4	Clc1cccc(c1)[C@H](CNCCNc1cccc(c1)c1cccc(c1)C(=O)O)O	10.1021/jm0509445
	DB06190	3636	None	34	Human	Functional	pEC50	=	5.4	5.4	-1202	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	410	9	4	4	4.4	Clc1cccc(c1)[C@H](CNCCNc1cccc(c1)c1cccc(c1)C(=O)O)O	10.1021/jm0509445
	44441236	93476	None	0	Human	Functional	pEC50	=	5.4	5.4	-3162	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	416	9	4	5	4.5	O=C(O)c1ccsc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL245875	93476	None	0	Human	Functional	pEC50	=	5.4	5.4	-3162	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	416	9	4	5	4.5	O=C(O)c1ccsc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1	10.1016/j.bmcl.2007.05.069
	10298567	65974	None	0	Human	Functional	pEC50	=	8.4	8.4	-5	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	465	12	5	6	3.3	COc1cccc(NC(=O)Nc2ccc(C[C@@H](CO)NC[C@H](O)COc3ccccc3)cc2)c1	10.1016/j.bmcl.2004.11.001
	CHEMBL183611	65974	None	0	Human	Functional	pEC50	=	8.4	8.4	-5	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	465	12	5	6	3.3	COc1cccc(NC(=O)Nc2ccc(C[C@@H](CO)NC[C@H](O)COc3ccccc3)cc2)c1	10.1016/j.bmcl.2004.11.001
	164625303	188696	None	0	Human	Functional	pEC50	=	8.4	8.4	-316	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4873082	188696	None	0	Human	Functional	pEC50	=	8.4	8.4	-316	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028871	188696	None	0	Human	Functional	pEC50	=	8.4	8.4	-316	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	164623918	188685	None	0	Human	Functional	pEC50	=	8.4	8.4	-199	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	374	7	4	4	2.8	O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4872480	188685	None	0	Human	Functional	pEC50	=	8.4	8.4	-199	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	374	7	4	4	2.8	O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5028793	188685	None	0	Human	Functional	pEC50	=	8.4	8.4	-199	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	374	7	4	4	2.8	O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	164608750	188565	None	0	Human	Functional	pEC50	=	8.4	8.4	-181	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4846631	188565	None	0	Human	Functional	pEC50	=	8.4	8.4	-181	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5027923	188565	None	0	Human	Functional	pEC50	=	8.4	8.4	-181	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	164615474	188615	None	0	Human	Functional	pEC50	=	8.4	8.4	-61	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4847767	188615	None	0	Human	Functional	pEC50	=	8.4	8.4	-61	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028315	188615	None	0	Human	Functional	pEC50	=	8.4	8.4	-61	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164617688	188629	None	0	Human	Functional	pEC50	=	8.4	8.4	-416	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4847536	188629	None	0	Human	Functional	pEC50	=	8.4	8.4	-416	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028449	188629	None	0	Human	Functional	pEC50	=	8.4	8.4	-416	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	56598967	88295	None	0	Human	Functional	pEC50	=	8.4	8.4	2238	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	457	14	4	6	3.2	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccccc1	10.1021/jm400348g
	CHEMBL2348211	88295	None	0	Human	Functional	pEC50	=	8.4	8.4	2238	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	457	14	4	6	3.2	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccccc1	10.1021/jm400348g
	45101520	201240	None	0	Human	Functional	pEC50	=	8.4	8.4	-3	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	513	12	7	8	1.2	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)CN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL583235	201240	None	0	Human	Functional	pEC50	=	8.4	8.4	-3	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	513	12	7	8	1.2	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)CN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	46232769	203297	None	0	Human	Functional	pEC50	=	8.4	8.4	-6	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL601036	203297	None	0	Human	Functional	pEC50	=	8.4	8.4	-6	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	164614743	188606	None	0	Human	Functional	pEC50	=	8.3	8.3	-134	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4860764	188606	None	0	Human	Functional	pEC50	=	8.3	8.3	-134	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028269	188606	None	0	Human	Functional	pEC50	=	8.3	8.3	-134	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	45484536	199670	None	0	Human	Functional	pEC50	=	8.3	8.3	-5	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	527	13	7	8	1.6	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)CCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL568239	199670	None	0	Human	Functional	pEC50	=	8.3	8.3	-5	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	527	13	7	8	1.6	CC(C)(Cc1ccc(NC(=O)CCCNC(=O)CCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	559926	97060	None	2	Guinea pig	Functional	pEC50	=	8.3	8.3	27	2	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	255	5	4	5	1.2	CC(C)(C)NCC(O)COc1ccc(O)c(O)c1	10.1021/jm00107a027
	CHEMBL266619	97060	None	2	Guinea pig	Functional	pEC50	=	8.3	8.3	27	2	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	255	5	4	5	1.2	CC(C)(C)NCC(O)COc1ccc(O)c(O)c1	10.1021/jm00107a027
	45270673	197880	None	0	Human	Functional	pEC50	=	7.4	7.4	58	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	406	10	3	5	3.9	O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)Oc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203992	197880	None	0	Human	Functional	pEC50	=	7.4	7.4	58	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	406	10	3	5	3.9	O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)Oc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL552253	197880	None	0	Human	Functional	pEC50	=	7.4	7.4	58	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	406	10	3	5	3.9	O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)Oc1ccccc1	10.1016/j.bmc.2009.06.031
	45273280	198175	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	435	11	4	4	3.7	O[C@@H](CNCCc1ccc(NC(=S)NCc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204006	198175	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	435	11	4	4	3.7	O[C@@H](CNCCc1ccc(NC(=S)NCc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL557095	198175	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	435	11	4	4	3.7	O[C@@H](CNCCc1ccc(NC(=S)NCc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	44396513	66744	None	0	Human	Functional	pEC50	=	7.4	7.4	-30	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	577	12	4	8	4.4	CC(C)S(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12	10.1016/j.bmcl.2004.10.035
	CHEMBL185660	66744	None	0	Human	Functional	pEC50	=	7.4	7.4	-30	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	577	12	4	8	4.4	CC(C)S(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12	10.1016/j.bmcl.2004.10.035
	10420352	168843	None	6	Guinea pig	Functional	pEC50	=	7.4	7.4	83	2	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	201	3	4	4	0.5	CNCC(O)c1ccc(O)c(O)c1F	10.1021/jm00118a019
	CHEMBL43711	168843	None	6	Guinea pig	Functional	pEC50	=	7.4	7.4	83	2	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	201	3	4	4	0.5	CNCC(O)c1ccc(O)c(O)c1F	10.1021/jm00118a019
	10076548	163359	None	0	Human	Functional	pEC50	=	7.4	7.4	-4	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	562	13	5	8	2.7	CCCCN(C(=O)CC(=O)O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1	10.1021/jm000544b
	CHEMBL418600	163359	None	0	Human	Functional	pEC50	=	7.4	7.4	-4	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	562	13	5	8	2.7	CCCCN(C(=O)CC(=O)O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1	10.1021/jm000544b
	24893966	176844	None	0	Human	Functional	pEC50	=	6.4	6.4	-724	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	449	12	3	5	4.8	CC(C)COc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL460257	176844	None	0	Human	Functional	pEC50	=	6.4	6.4	-724	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	449	12	3	5	4.8	CC(C)COc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	44331766	4660	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	449	9	3	4	4.3	O[C@@H](CNCC1CCN(CCC(F)(F)F)CC1)COc1cccc2[nH]c3ccccc3c12	10.1016/s0960-894x(02)00607-8
	CHEMBL103137	4660	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	449	9	3	4	4.3	O[C@@H](CNCC1CCN(CCC(F)(F)F)CC1)COc1cccc2[nH]c3ccccc3c12	10.1016/s0960-894x(02)00607-8
	22063464	203467	None	0	Human	Functional	pEC50	=	7.4	7.4	-10	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1cccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmcl.2009.12.087
	CHEMBL602257	203467	None	0	Human	Functional	pEC50	=	7.4	7.4	-10	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1cccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmcl.2009.12.087
	10189730	5279	None	0	Human	Functional	pEC50	=	6.4	6.4	-426	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	647	14	6	8	3.4	CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCCc2ccc(NC3CCN(C(=O)NCc4cc(F)ccc4F)CC3)cc2)ccc1O	10.1016/s0960-894x(01)00645-x
	CHEMBL106511	5279	None	0	Human	Functional	pEC50	=	6.4	6.4	-426	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	647	14	6	8	3.4	CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCCc2ccc(NC3CCN(C(=O)NCc4cc(F)ccc4F)CC3)cc2)ccc1O	10.1016/s0960-894x(01)00645-x
	145984324	165934	None	0	Human	Functional	pEC50	=	6.4	6.4	-7	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	449	11	4	4	4.6	CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=S)Nc2ccccc2)cc1	10.1016/j.ejmech.2018.03.032
	CHEMBL4248727	165934	None	0	Human	Functional	pEC50	=	6.4	6.4	-7	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	449	11	4	4	4.6	CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=S)Nc2ccccc2)cc1	10.1016/j.ejmech.2018.03.032
	44574723	178628	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	439	11	3	5	3.5	O=C(Cc1cccc(Cl)n1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL466726	178628	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	439	11	3	5	3.5	O=C(Cc1cccc(Cl)n1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	155567283	176074	None	0	Human	Functional	pEC50	=	7.4	7.4	-588	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.bmc.2018.10.043
	CHEMBL4588479	176074	None	0	Human	Functional	pEC50	=	7.4	7.4	-588	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.bmc.2018.10.043
	44377771	165642	None	0	Human	Functional	pEC50	=	6.4	6.4	-70	3	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	596	10	5	9	3.4	O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)c4ccc(O)c(NS(=O)(=O)c5ccccc5)c4)CC3)cc2)S1	10.1016/s0960-894x(01)00063-4
	CHEMBL424167	165642	None	0	Human	Functional	pEC50	=	6.4	6.4	-70	3	Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor	ChEMBL	596	10	5	9	3.4	O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)c4ccc(O)c(NS(=O)(=O)c5ccccc5)c4)CC3)cc2)S1	10.1016/s0960-894x(01)00063-4
	1028	291	None	40	Guinea pig	Functional	pEC50	=	6.4	6.4	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	139148732	291	None	40	Guinea pig	Functional	pEC50	=	6.4	6.4	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	479	291	None	40	Guinea pig	Functional	pEC50	=	6.4	6.4	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	5816	291	None	40	Guinea pig	Functional	pEC50	=	6.4	6.4	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	5816.0	291	None	40	Guinea pig	Functional	pEC50	=	6.4	6.4	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	CHEMBL679	291	None	40	Guinea pig	Functional	pEC50	=	6.4	6.4	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	DB00668	291	None	40	Guinea pig	Functional	pEC50	=	6.4	6.4	-6	19	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	46232856	203800	None	0	Human	Functional	pEC50	=	6.4	6.4	-128	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	424	6	4	5	3.4	CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL604333	203800	None	0	Human	Functional	pEC50	=	6.4	6.4	-128	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	424	6	4	5	3.4	CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	10651147	110746	None	0	Human	Functional	pEC50	=	4.4	4.4	-10964	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	596	12	6	8	2.5	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	CHEMBL32599	110746	None	0	Human	Functional	pEC50	=	4.4	4.4	-10964	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	596	12	6	8	2.5	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	44392542	65883	None	0	Human	Functional	pEC50	=	7.4	7.4	-6	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	543	11	4	6	5.5	C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NCc2ccc3ccccc3c2)c1	10.1016/j.bmcl.2004.12.033
	CHEMBL183552	65883	None	0	Human	Functional	pEC50	=	7.4	7.4	-6	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	543	11	4	6	5.5	C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NCc2ccc3ccccc3c2)c1	10.1016/j.bmcl.2004.12.033
	11432806	66218	None	0	Human	Functional	pEC50	=	7.4	7.4	-134	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	549	11	4	8	3.6	C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.09.054
	11432806	66218	None	0	Human	Functional	pEC50	=	7.4	7.4	-134	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	549	11	4	8	3.6	C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	CHEMBL184407	66218	None	0	Human	Functional	pEC50	=	7.4	7.4	-134	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	549	11	4	8	3.6	C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.09.054
	CHEMBL184407	66218	None	0	Human	Functional	pEC50	=	7.4	7.4	-134	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	549	11	4	8	3.6	C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	164612025	188584	None	0	Human	Functional	pEC50	=	7.4	7.4	-2454	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4860454	188584	None	0	Human	Functional	pEC50	=	7.4	7.4	-2454	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028117	188584	None	0	Human	Functional	pEC50	=	7.4	7.4	-2454	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	24895669	190776	None	0	Human	Functional	pEC50	=	6.4	6.4	-7079	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	435	10	4	5	4.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(O)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL518168	190776	None	0	Human	Functional	pEC50	=	6.4	6.4	-7079	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	435	10	4	5	4.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(O)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	44392575	64393	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	441	10	4	6	2.8	C#CCNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1	10.1016/j.bmcl.2004.12.033
	CHEMBL181300	64393	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	3	Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor	ChEMBL	441	10	4	6	2.8	C#CCNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1	10.1016/j.bmcl.2004.12.033
	52949489	17554	None	0	Human	Functional	pEC50	=	6.4	6.4	-21	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	490	9	2	8	4.4	COc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1	10.1016/j.bmcl.2010.08.039
	CHEMBL1258024	17554	None	0	Human	Functional	pEC50	=	6.4	6.4	-21	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	490	9	2	8	4.4	COc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1	10.1016/j.bmcl.2010.08.039
	44268324	16791	None	0	Human	Functional	pEC50	=	6.4	6.4	-141	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	476	11	4	6	3.4	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccc(Cl)cc1	10.1016/s0960-894x(98)00169-3
	CHEMBL12450	16791	None	0	Human	Functional	pEC50	=	6.4	6.4	-141	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	476	11	4	6	3.4	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccc(Cl)cc1	10.1016/s0960-894x(98)00169-3
	10626150	100080	None	0	Human	Functional	pEC50	=	5.4	5.4	-295	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	534	11	5	9	1.3	CCOC(=O)CNC(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1	10.1021/jm000544b
	CHEMBL286868	100080	None	0	Human	Functional	pEC50	=	5.4	5.4	-295	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	534	11	5	9	1.3	CCOC(=O)CNC(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1	10.1021/jm000544b
	44336180	6471	None	0	Human	Functional	pEC50	=	6.3	6.3	-15	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	554	12	5	6	4.0	O=C(NCc1ccc(F)cc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL108263	6471	None	0	Human	Functional	pEC50	=	6.3	6.3	-15	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	554	12	5	6	4.0	O=C(NCc1ccc(F)cc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	11270071	99044	None	0	Human	Functional	pEC50	=	7.3	7.3	1	3	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	328	6	3	2	4.1	C[C@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	CHEMBL279931	99044	None	0	Human	Functional	pEC50	=	7.3	7.3	1	3	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	328	6	3	2	4.1	C[C@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	5311452	3671	None	7	Human	Functional	pEC50	=	7.3	7.3	-5	4	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	325	7	2	3	3.7	CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O	10.1016/j.ejmech.2022.114961
	547	3671	None	7	Human	Functional	pEC50	=	7.3	7.3	-5	4	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	325	7	2	3	3.7	CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O	10.1016/j.ejmech.2022.114961
	CHEMBL1326499	3671	None	7	Human	Functional	pEC50	=	7.3	7.3	-5	4	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	325	7	2	3	3.7	CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O	10.1016/j.ejmech.2022.114961
	24949564	189630	None	0	Human	Functional	pEC50	=	6.3	6.3	-147	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	452	7	4	5	4.6	Nc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1	10.1021/jm800222k
	CHEMBL514094	189630	None	0	Human	Functional	pEC50	=	6.3	6.3	-147	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	452	7	4	5	4.6	Nc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1	10.1021/jm800222k
	24893964	186771	None	0	Human	Functional	pEC50	=	6.3	6.3	-1862	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	460	10	3	5	5.0	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1	10.1021/jm8000345
	CHEMBL488224	186771	None	0	Human	Functional	pEC50	=	6.3	6.3	-1862	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	460	10	3	5	5.0	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1	10.1021/jm8000345
	24893964	186771	None	0	Human	Functional	pEC50	=	6.3	6.3	-1862	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	460	10	3	5	5.0	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	CHEMBL488224	186771	None	0	Human	Functional	pEC50	=	6.3	6.3	-1862	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	460	10	3	5	5.0	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	3038500	9342	None	11	Human	Functional	pEC50	=	5.3	5.3	-831	6	In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.	ChEMBL	624	11	3	7	6.6	O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1021/jm000286i
	CHEMBL111201	9342	None	11	Human	Functional	pEC50	=	5.3	5.3	-831	6	In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.	ChEMBL	624	11	3	7	6.6	O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1021/jm000286i
	10187653	4337	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	554	11	5	7	3.5	O=C(Nc1ccccc1)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	CHEMBL100970	4337	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	554	11	5	7	3.5	O=C(Nc1ccccc1)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	44396736	66889	None	0	Human	Functional	pEC50	=	7.3	7.3	-11	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	617	12	4	9	5.1	C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3cccs3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	CHEMBL186271	66889	None	0	Human	Functional	pEC50	=	7.3	7.3	-11	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	617	12	4	9	5.1	C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3cccs3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	44127056	197821	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	426	11	4	6	3.2	O=C(Cc1ccsc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL551892	197821	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	426	11	4	6	3.2	O=C(Cc1ccsc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	24949420	188221	None	1	Human	Functional	pEC50	=	6.3	6.3	-51	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	422	6	3	4	4.3	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)nc1	10.1021/jm800222k
	CHEMBL498304	188221	None	1	Human	Functional	pEC50	=	6.3	6.3	-51	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	422	6	3	4	4.3	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)nc1	10.1021/jm800222k
	42639652	12735	None	0	Human	Functional	pEC50	=	6.3	6.3	-1513	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	495	11	3	6	3.5	CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL1187716	12735	None	0	Human	Functional	pEC50	=	6.3	6.3	-1513	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	495	11	3	6	3.5	CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL516209	12735	None	0	Human	Functional	pEC50	=	6.3	6.3	-1513	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	495	11	3	6	3.5	CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	45483847	199268	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	432	7	4	5	4.0	CC(C)(Cc1ccc(-c2ccccc2)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL565686	199268	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	432	7	4	5	4.0	CC(C)(Cc1ccc(-c2ccccc2)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	45483816	199592	None	0	Human	Functional	pEC50	=	8.3	8.3	-12	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1cccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)c1	10.1016/j.bmcl.2009.10.013
	CHEMBL567833	199592	None	0	Human	Functional	pEC50	=	8.3	8.3	-12	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1cccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)c1	10.1016/j.bmcl.2009.10.013
	52947562	17694	None	0	Human	Functional	pEC50	=	8.3	8.3	3	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	384	7	2	7	2.7	OC(CNC1CCN(c2ncnc3sccc23)CC1)COc1ccccc1	10.1016/j.bmcl.2010.08.039
	CHEMBL1258486	17694	None	0	Human	Functional	pEC50	=	8.3	8.3	3	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	384	7	2	7	2.7	OC(CNC1CCN(c2ncnc3sccc23)CC1)COc1ccccc1	10.1016/j.bmcl.2010.08.039
	11026016	46714	None	0	Human	Functional	pEC50	=	8.3	8.3	1	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	411	10	4	5	2.5	C[C@H](CNc1ccc(CNS(C)(=O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL153916	46714	None	0	Human	Functional	pEC50	=	8.3	8.3	1	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	411	10	4	5	2.5	C[C@H](CNc1ccc(CNS(C)(=O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	10902809	48091	None	0	Human	Functional	pEC50	=	8.3	8.3	1	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	304	7	3	3	3.5	C[C@H](CNc1ccccc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL155072	48091	None	0	Human	Functional	pEC50	=	8.3	8.3	1	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	304	7	3	3	3.5	C[C@H](CNc1ccccc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	2419	3463	None	53	Guinea pig	Functional	pEC50	=	8.3	8.3	-8	19	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	5152	3463	None	53	Guinea pig	Functional	pEC50	=	8.3	8.3	-8	19	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	5152.0	3463	None	53	Guinea pig	Functional	pEC50	=	8.3	8.3	-8	19	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	559	3463	None	53	Guinea pig	Functional	pEC50	=	8.3	8.3	-8	19	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	CHEMBL1263	3463	None	53	Guinea pig	Functional	pEC50	=	8.3	8.3	-8	19	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	DB00938	3463	None	53	Guinea pig	Functional	pEC50	=	8.3	8.3	-8	19	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	155543358	174877	None	0	Human	Functional	pEC50	=	8.3	8.3	-102	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccccc3O)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4561253	174877	None	0	Human	Functional	pEC50	=	8.3	8.3	-102	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccccc3O)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	45484568	200806	None	0	Human	Functional	pEC50	=	8.3	8.3	-10	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	541	13	6	8	1.8	CN(C)CC(=O)NCCCC(=O)Nc1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.06.104
	CHEMBL576428	200806	None	0	Human	Functional	pEC50	=	8.3	8.3	-10	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	541	13	6	8	1.8	CN(C)CC(=O)NCCCC(=O)Nc1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.06.104
	45483843	199492	None	0	Human	Functional	pEC50	=	8.3	8.3	-9	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	384	7	4	5	2.9	CCc1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.10.013
	CHEMBL567192	199492	None	0	Human	Functional	pEC50	=	8.3	8.3	-9	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	384	7	4	5	2.9	CCc1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.10.013
	45484569	200090	None	0	Human	Functional	pEC50	=	8.2	8.2	-4	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	596	13	6	9	1.5	CN1CCN(CC(=O)NCCCC(=O)Nc2ccc(CC(C)(C)NCC(O)c3ccc(O)c4c3OCC(=O)N4)cc2)CC1	10.1016/j.bmcl.2009.06.104
	CHEMBL570834	200090	None	0	Human	Functional	pEC50	=	8.2	8.2	-4	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	596	13	6	9	1.5	CN1CCN(CC(=O)NCCCC(=O)Nc2ccc(CC(C)(C)NCC(O)c3ccc(O)c4c3OCC(=O)N4)cc2)CC1	10.1016/j.bmcl.2009.06.104
	45268128	198778	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	427	10	4	4	3.9	O[C@@H](CNCCc1ccc(NC(=S)NC2CCCCC2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203988	198778	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	427	10	4	4	3.9	O[C@@H](CNCCc1ccc(NC(=S)NC2CCCCC2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL562315	198778	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	427	10	4	4	3.9	O[C@@H](CNCCc1ccc(NC(=S)NC2CCCCC2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	10233153	4230	None	0	Human	Functional	pEC50	=	7.3	7.3	-5	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	642	11	5	9	3.1	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4ccc5c(C(=O)O)cccc54)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	CHEMBL100351	4230	None	0	Human	Functional	pEC50	=	7.3	7.3	-5	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	642	11	5	9	3.1	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4ccc5c(C(=O)O)cccc54)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	10553602	127220	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	506	10	6	8	0.9	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(=O)NCC(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	CHEMBL36568	127220	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	506	10	6	8	0.9	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(=O)NCC(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	9893058	66403	None	0	Human	Functional	pEC50	=	7.3	7.3	-39	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	525	17	5	8	2.9	O=c1ccn(-c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)c(=O)[nH]1	10.1016/j.bmc.2011.05.064
	CHEMBL1814267	66403	None	0	Human	Functional	pEC50	=	7.3	7.3	-39	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	525	17	5	8	2.9	O=c1ccn(-c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)c(=O)[nH]1	10.1016/j.bmc.2011.05.064
	CHEMBL1851721	66403	None	0	Human	Functional	pEC50	=	7.3	7.3	-39	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	525	17	5	8	2.9	O=c1ccn(-c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)c(=O)[nH]1	10.1016/j.bmc.2011.05.064
	56678849	66647	None	0	Human	Functional	pEC50	=	7.3	7.3	-63	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	541	18	5	8	2.7	O=C1NC(=O)N(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	CHEMBL1814275	66647	None	0	Human	Functional	pEC50	=	7.3	7.3	-63	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	541	18	5	8	2.7	O=C1NC(=O)N(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	CHEMBL1852744	66647	None	0	Human	Functional	pEC50	=	7.3	7.3	-63	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	541	18	5	8	2.7	O=C1NC(=O)N(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	56675663	66610	None	0	Human	Functional	pEC50	=	7.3	7.3	-50	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	541	17	6	6	4.6	NC(=O)Nc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(C(F)(F)F)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835861	66610	None	0	Human	Functional	pEC50	=	7.3	7.3	-50	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	541	17	6	6	4.6	NC(=O)Nc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(C(F)(F)F)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852575	66610	None	0	Human	Functional	pEC50	=	7.3	7.3	-50	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	541	17	6	6	4.6	NC(=O)Nc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(C(F)(F)F)c1	10.1016/j.bmc.2011.08.043
	46833102	14211	None	0	Human	Functional	pEC50	=	7.3	7.3	-31	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	496	17	5	8	1.9	NS(=O)(=O)c1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL1084656	14211	None	0	Human	Functional	pEC50	=	7.3	7.3	-31	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	496	17	5	8	1.9	NS(=O)(=O)c1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL1198882	14211	None	0	Human	Functional	pEC50	=	7.3	7.3	-31	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	496	17	5	8	1.9	NS(=O)(=O)c1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	44574913	178681	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	526	15	2	6	4.5	CCCN(C(=O)Cc1nccn1Cc1ccccc1)c1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL467117	178681	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	526	15	2	6	4.5	CCCN(C(=O)Cc1nccn1Cc1ccccc1)c1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	24895667	176956	None	0	Human	Functional	pEC50	=	6.3	6.3	-208	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	453	10	3	4	5.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(Cl)cc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL461282	176956	None	0	Human	Functional	pEC50	=	6.3	6.3	-208	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	453	10	3	4	5.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(Cl)cc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	10003858	189204	None	1	Human	Functional	pEC50	=	6.3	6.3	-3548	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	449	10	4	5	4.8	CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccc(O)cc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL510100	189204	None	1	Human	Functional	pEC50	=	6.3	6.3	-3548	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	449	10	4	5	4.8	CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccc(O)cc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	42625513	12563	None	0	Human	Functional	pEC50	=	6.3	6.3	-1000	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm801016j
	CHEMBL1186722	12563	None	0	Human	Functional	pEC50	=	6.3	6.3	-1000	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm801016j
	CHEMBL475389	12563	None	0	Human	Functional	pEC50	=	6.3	6.3	-1000	4	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm801016j
	42625515	12734	None	0	Human	Functional	pEC50	=	6.3	6.3	-794	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	508	18	5	7	3.0	CNS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1187711	12734	None	0	Human	Functional	pEC50	=	6.3	6.3	-794	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	508	18	5	7	3.0	CNS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL516056	12734	None	0	Human	Functional	pEC50	=	6.3	6.3	-794	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	508	18	5	7	3.0	CNS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	11718543	165927	None	0	Human	Functional	pEC50	=	5.3	5.3	-125	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	411	9	4	5	3.8	O=C(O)c1cccc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)n1	10.1021/jm0509445
	CHEMBL424866	165927	None	0	Human	Functional	pEC50	=	5.3	5.3	-125	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	411	9	4	5	3.8	O=C(O)c1cccc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)n1	10.1021/jm0509445
	9801145	93475	None	0	Human	Functional	pEC50	=	5.3	5.3	-630	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	400	9	4	5	4.0	O=C(O)c1ccoc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL245874	93475	None	0	Human	Functional	pEC50	=	5.3	5.3	-630	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	400	9	4	5	4.0	O=C(O)c1ccoc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1	10.1016/j.bmcl.2007.05.069
	11605652	12559	None	0	Human	Functional	pEC50	=	5.3	5.3	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1186715	12559	None	0	Human	Functional	pEC50	=	5.3	5.3	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL475236	12559	None	0	Human	Functional	pEC50	=	5.3	5.3	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	44392240	64340	None	0	Human	Functional	pEC50	=	7.3	7.3	-6	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	401	12	5	5	2.2	CCCNC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	CHEMBL181115	64340	None	0	Human	Functional	pEC50	=	7.3	7.3	-6	2	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	401	12	5	5	2.2	CCCNC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmcl.2004.11.001
	44580010	186905	None	0	Human	Functional	pEC50	=	6.3	6.3	-46	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	441	10	3	5	4.7	COc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	CHEMBL489199	186905	None	0	Human	Functional	pEC50	=	6.3	6.3	-46	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	441	10	3	5	4.7	COc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	24894319	189968	None	0	Human	Functional	pEC50	=	6.3	6.3	-213	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	435	11	3	5	4.5	CC(C)Oc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL516785	189968	None	0	Human	Functional	pEC50	=	6.3	6.3	-213	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	435	11	3	5	4.5	CC(C)Oc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	10202842	164254	None	0	Human	Functional	pEC50	=	6.3	6.3	-16	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	428	10	5	6	1.9	NC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL421030	164254	None	0	Human	Functional	pEC50	=	6.3	6.3	-16	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	428	10	5	6	1.9	NC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	24895561	176958	None	0	Human	Functional	pEC50	=	7.3	7.3	-194	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	509	11	3	5	6.1	O=C(O)c1ccc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1	10.1021/jm8000345
	CHEMBL461301	176958	None	0	Human	Functional	pEC50	=	7.3	7.3	-194	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	509	11	3	5	6.1	O=C(O)c1ccc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1	10.1021/jm8000345
	44331443	4450	None	0	Human	Functional	pEC50	=	6.3	6.3	-26	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	689	14	7	9	2.3	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	CHEMBL101674	4450	None	0	Human	Functional	pEC50	=	6.3	6.3	-26	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	689	14	7	9	2.3	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	44331351	210600	None	0	Human	Functional	pEC50	=	6.3	6.3	-16	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	610	13	6	8	2.7	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(c3ccc(C(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	CHEMBL98088	210600	None	0	Human	Functional	pEC50	=	6.3	6.3	-16	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	610	13	6	8	2.7	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(c3ccc(C(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	10209574	5441	None	0	Human	Functional	pEC50	=	6.3	6.3	-22	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	554	12	5	6	4.0	O=C(NCc1cc(F)ccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL107382	5441	None	0	Human	Functional	pEC50	=	6.3	6.3	-22	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	554	12	5	6	4.0	O=C(NCc1cc(F)ccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	10304565	107433	None	0	Human	Functional	pEC50	=	6.3	6.3	-11	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	622	12	5	7	3.6	O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)c(F)c3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	CHEMBL317809	107433	None	0	Human	Functional	pEC50	=	6.3	6.3	-11	2	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	622	12	5	7	3.6	O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)c(F)c3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	44396577	66973	None	0	Human	Functional	pEC50	=	7.3	7.3	-25	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	561	12	4	6	5.9	C[C@H](Cc1c[nH]c2c(OCc3ccccc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	CHEMBL186676	66973	None	0	Human	Functional	pEC50	=	7.3	7.3	-25	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	561	12	4	6	5.9	C[C@H](Cc1c[nH]c2c(OCc3ccccc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	24822817	95348	None	0	Human	Functional	pEC50	=	7.3	7.3	-120	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	493	10	3	4	6.3	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1	10.1021/jm701324c
	CHEMBL256418	95348	None	0	Human	Functional	pEC50	=	7.3	7.3	-120	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	493	10	3	4	6.3	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1	10.1021/jm701324c
	24822817	95348	None	0	Human	Functional	pEC50	=	7.3	7.3	-120	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	493	10	3	4	6.3	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1	10.1021/jm8000345
	CHEMBL256418	95348	None	0	Human	Functional	pEC50	=	7.3	7.3	-120	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	493	10	3	4	6.3	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1	10.1021/jm8000345
	24822817	95348	None	0	Human	Functional	pEC50	=	7.3	7.3	-120	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	493	10	3	4	6.3	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	CHEMBL256418	95348	None	0	Human	Functional	pEC50	=	7.3	7.3	-120	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	493	10	3	4	6.3	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	44237613	58250	None	0	Rat	Functional	pEC50	=	6.3	6.3	-2754	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	502	10	6	6	3.4	COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682215	58250	None	0	Rat	Functional	pEC50	=	6.3	6.3	-2754	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	502	10	6	6	3.4	COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	44580009	186907	None	0	Human	Functional	pEC50	=	6.3	6.3	-42	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	425	9	3	4	5.0	Cc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	CHEMBL489201	186907	None	0	Human	Functional	pEC50	=	6.3	6.3	-42	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	425	9	3	4	5.0	Cc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	44127575	194936	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	426	11	4	6	3.2	O=C(Cc1cccs1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL539226	194936	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	426	11	4	6	3.2	O=C(Cc1cccs1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	45270391	197910	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	459	11	4	6	3.8	O=C(CC1C=Nc2ccccc21)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL552434	197910	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	459	11	4	6	3.8	O=C(CC1C=Nc2ccccc21)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	45273276	198140	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	429	10	4	5	3.6	N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204005	198140	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	429	10	4	5	3.6	N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL556689	198140	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	429	10	4	5	3.6	N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	24822472	97467	None	0	Human	Functional	pEC50	=	6.2	6.2	-38	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	409	8	3	3	4.9	Cc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm701324c
	CHEMBL269920	97467	None	0	Human	Functional	pEC50	=	6.2	6.2	-38	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	409	8	3	3	4.9	Cc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm701324c
	44237670	58254	None	0	Rat	Functional	pEC50	=	5.2	5.2	-8128	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	534	9	6	5	5.4	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)Nc1ccccc1-c1ccccc1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682219	58254	None	0	Rat	Functional	pEC50	=	5.2	5.2	-8128	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	534	9	6	5	5.4	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)Nc1ccccc1-c1ccccc1	10.1016/j.bmcl.2010.12.096
	44396737	66879	None	0	Human	Functional	pEC50	=	7.2	7.2	-47	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	683	14	4	10	5.2	CCOC(=O)c1ccc(S(=O)(=O)Oc2cccc3c(C[C@@H](C)NC[C@H](O)c4cccc(NS(=O)(=O)c5cccs5)c4)c[nH]c23)cc1	10.1016/j.bmcl.2004.10.035
	CHEMBL186236	66879	None	0	Human	Functional	pEC50	=	7.2	7.2	-47	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	683	14	4	10	5.2	CCOC(=O)c1ccc(S(=O)(=O)Oc2cccc3c(C[C@@H](C)NC[C@H](O)c4cccc(NS(=O)(=O)c5cccs5)c4)c[nH]c23)cc1	10.1016/j.bmcl.2004.10.035
	44444173	94034	None	0	Human	Functional	pEC50	=	7.2	7.2	-8	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levelAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP level	ChEMBL	516	11	4	7	3.3	CC(C)(Cc1ccc(Oc2ccc(C(N)=O)cn2)cc1)NC[C@H](O)COc1cccc2c1C1(CC1)C(=O)N2	10.1016/j.bmcl.2007.09.011
	CHEMBL248547	94034	None	0	Human	Functional	pEC50	=	7.2	7.2	-8	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levelAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP level	ChEMBL	516	11	4	7	3.3	CC(C)(Cc1ccc(Oc2ccc(C(N)=O)cn2)cc1)NC[C@H](O)COc1cccc2c1C1(CC1)C(=O)N2	10.1016/j.bmcl.2007.09.011
	44331426	4424	None	0	Human	Functional	pEC50	=	6.2	6.2	-114	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	578	13	7	9	1.0	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(c3ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	CHEMBL101521	4424	None	0	Human	Functional	pEC50	=	6.2	6.2	-114	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	578	13	7	9	1.0	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(c3ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	44127048	197811	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	436	11	5	6	2.6	O=C(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C(O)c1ccccc1	10.1016/j.ejmech.2009.01.022
	CHEMBL551832	197811	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	436	11	5	6	2.6	O=C(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C(O)c1ccccc1	10.1016/j.ejmech.2009.01.022
	1499	2091	None	34	Guinea pig	Functional	pEC50	=	8.2	8.2	-60	38	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00107a027
	3779	2091	None	34	Guinea pig	Functional	pEC50	=	8.2	8.2	-60	38	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00107a027
	3779.0	2091	None	34	Guinea pig	Functional	pEC50	=	8.2	8.2	-60	38	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00107a027
	536	2091	None	34	Guinea pig	Functional	pEC50	=	8.2	8.2	-60	38	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00107a027
	CHEMBL434	2091	None	34	Guinea pig	Functional	pEC50	=	8.2	8.2	-60	38	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00107a027
	DB01064	2091	None	34	Guinea pig	Functional	pEC50	=	8.2	8.2	-60	38	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00107a027
	24936491	17527	None	0	Human	Functional	pEC50	=	8.2	8.2	-2	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	494	8	3	8	4.2	Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccc(F)cc5)c34)CC2)cc1	10.1016/j.bmcl.2010.08.039
	CHEMBL1257916	17527	None	0	Human	Functional	pEC50	=	8.2	8.2	-2	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	494	8	3	8	4.2	Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccc(F)cc5)c34)CC2)cc1	10.1016/j.bmcl.2010.08.039
	9845282	75979	None	0	Human	Functional	pEC50	=	8.2	8.2	-63	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	424	9	4	4	4.8	C[C@H](CNc1cccc(-c2cccc(C(=O)O)c2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	CHEMBL205224	75979	None	0	Human	Functional	pEC50	=	8.2	8.2	-63	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	424	9	4	4	4.8	C[C@H](CNc1cccc(-c2cccc(C(=O)O)c2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	155564079	175515	None	0	Human	Functional	pEC50	=	8.2	8.2	-97	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	442	8	4	4	4.9	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4575759	175515	None	0	Human	Functional	pEC50	=	8.2	8.2	-97	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	442	8	4	4	4.9	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	56943515	112507	None	0	Human	Functional	pEC50	=	8.2	8.2	-7	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	478	13	6	7	3.7	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298213	112507	None	0	Human	Functional	pEC50	=	8.2	8.2	-7	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	478	13	6	7	3.7	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1	10.1016/j.bmcl.2014.04.095
	11169365	112575	None	0	Human	Functional	pEC50	=	8.2	8.2	-22	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298986	112575	None	0	Human	Functional	pEC50	=	8.2	8.2	-22	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	164612262	188586	None	0	Human	Functional	pEC50	=	8.2	8.2	-190	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4853372	188586	None	0	Human	Functional	pEC50	=	8.2	8.2	-190	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028127	188586	None	0	Human	Functional	pEC50	=	8.2	8.2	-190	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	5493324	98956	None	24	Human	Functional	pEC50	=	8.2	8.2	-208	3	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	402	9	4	4	3.5	C[C@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	CHEMBL279260	98956	None	24	Human	Functional	pEC50	=	8.2	8.2	-208	3	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	402	9	4	4	3.5	C[C@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	24822972	97584	None	0	Human	Functional	pEC50	=	8.2	8.2	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	425	9	3	4	4.6	COc1cc(CCNC[C@H](O)c2cccc(Cl)c2)ccc1-c1ccc(C(=O)O)cc1	10.1021/jm701324c
	CHEMBL270460	97584	None	0	Human	Functional	pEC50	=	8.2	8.2	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	425	9	3	4	4.6	COc1cc(CCNC[C@H](O)c2cccc(Cl)c2)ccc1-c1ccc(C(=O)O)cc1	10.1021/jm701324c
	52948056	17526	None	0	Human	Functional	pEC50	=	8.2	8.2	1	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	478	8	2	7	4.5	OC(CNC1CCN(c2ncnc3scc(-c4ccc(F)cc4)c23)CC1)COc1ccccc1	10.1016/j.bmcl.2010.08.039
	CHEMBL1257915	17526	None	0	Human	Functional	pEC50	=	8.2	8.2	1	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	478	8	2	7	4.5	OC(CNC1CCN(c2ncnc3scc(-c4ccc(F)cc4)c23)CC1)COc1ccccc1	10.1016/j.bmcl.2010.08.039
	45483844	200852	None	0	Human	Functional	pEC50	=	8.2	8.2	-4	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	398	7	4	5	3.5	CC(C)c1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.10.013
	CHEMBL576848	200852	None	0	Human	Functional	pEC50	=	8.2	8.2	-4	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	398	7	4	5	3.5	CC(C)c1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1	10.1016/j.bmcl.2009.10.013
	155513474	169843	None	0	Human	Functional	pEC50	=	8.2	8.2	-83	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	478	8	4	4	5.1	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4438531	169843	None	0	Human	Functional	pEC50	=	8.2	8.2	-83	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	478	8	4	4	5.1	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	164618278	188634	None	0	Human	Functional	pEC50	=	8.2	8.2	-389	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848018	188634	None	0	Human	Functional	pEC50	=	8.2	8.2	-389	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028489	188634	None	0	Human	Functional	pEC50	=	8.2	8.2	-389	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	45271518	197331	None	0	Human	Functional	pEC50	=	7.2	7.2	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	479	11	4	6	3.9	COC(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203999	197331	None	0	Human	Functional	pEC50	=	7.2	7.2	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	479	11	4	6	3.9	COC(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL549689	197331	None	0	Human	Functional	pEC50	=	7.2	7.2	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	479	11	4	6	3.9	COC(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	45270690	197577	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	466	11	4	6	4.0	O=[N+]([O-])c1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203994	197577	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	466	11	4	6	4.0	O=[N+]([O-])c1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL550037	197577	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	466	11	4	6	4.0	O=[N+]([O-])c1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.06.031
	45273281	198194	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2Cl)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL2448075	198194	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2Cl)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL557295	198194	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2Cl)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	10008017	99926	None	10	Human	Functional	pEC50	=	7.2	7.2	-7	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	562	12	6	8	2.3	CC(C)C[C@H](NC(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1)C(=O)O	10.1021/jm000544b
	CHEMBL285881	99926	None	10	Human	Functional	pEC50	=	7.2	7.2	-7	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	562	12	6	8	2.3	CC(C)C[C@H](NC(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1)C(=O)O	10.1021/jm000544b
	44127782	199131	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	470	11	4	5	4.3	O=C(Cc1cccc2ccccc12)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL564556	199131	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	470	11	4	5	4.3	O=C(Cc1cccc2ccccc12)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	52944986	17620	None	0	Human	Functional	pEC50	=	6.2	6.2	-72	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	478	8	2	7	4.5	OC(CNC1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1)COc1ccccc1F	10.1016/j.bmcl.2010.08.039
	CHEMBL1258257	17620	None	0	Human	Functional	pEC50	=	6.2	6.2	-72	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	478	8	2	7	4.5	OC(CNC1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1)COc1ccccc1F	10.1016/j.bmcl.2010.08.039
	10187201	5183	None	0	Human	Functional	pEC50	=	6.2	6.2	-77	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	540	17	5	6	4.9	CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL106022	5183	None	0	Human	Functional	pEC50	=	6.2	6.2	-77	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	540	17	5	6	4.9	CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	44312924	164921	None	0	Human	Functional	pEC50	=	5.2	5.2	-123	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	421	6	3	6	4.2	COc1cc(-c2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)cc(OC)c1OC	10.1016/s0960-894x(00)00459-5
	CHEMBL421871	164921	None	0	Human	Functional	pEC50	=	5.2	5.2	-123	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	421	6	3	6	4.2	COc1cc(-c2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)cc(OC)c1OC	10.1016/s0960-894x(00)00459-5
	44219641	178544	None	0	Human	Functional	pEC50	=	7.2	7.2	-5	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	498	13	3	6	4.1	CC(Cc1ccc(NC(=O)Cc2nccn2Cc2ccccc2)cc1)NC[C@H](O)COc1ccccc1	10.1016/j.bmc.2009.03.044
	CHEMBL466088	178544	None	0	Human	Functional	pEC50	=	7.2	7.2	-5	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	498	13	3	6	4.1	CC(Cc1ccc(NC(=O)Cc2nccn2Cc2ccccc2)cc1)NC[C@H](O)COc1ccccc1	10.1016/j.bmc.2009.03.044
	24895791	186746	None	0	Human	Functional	pEC50	=	7.2	7.2	-199	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	419	10	3	4	4.7	CCOc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL488051	186746	None	0	Human	Functional	pEC50	=	7.2	7.2	-199	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	419	10	3	4	4.7	CCOc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	44580040	187226	None	0	Human	Functional	pEC50	=	6.2	6.2	-389	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	510	10	4	5	5.7	CC(C)(C)C(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	CHEMBL491645	187226	None	0	Human	Functional	pEC50	=	6.2	6.2	-389	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	510	10	4	5	5.7	CC(C)(C)C(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	24950560	172847	None	0	Human	Functional	pEC50	=	6.2	6.2	-16	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	421	6	3	3	4.9	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccccc2Cl)CC3)cc1	10.1021/jm800222k
	CHEMBL450842	172847	None	0	Human	Functional	pEC50	=	6.2	6.2	-16	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	421	6	3	3	4.9	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccccc2Cl)CC3)cc1	10.1021/jm800222k
	145984042	165770	None	0	Human	Functional	pEC50	=	5.2	5.2	-1348	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	475	13	4	5	3.1	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)Cc3ccccc3)cc2)c1	10.1016/j.ejmech.2018.03.032
	CHEMBL4244929	165770	None	0	Human	Functional	pEC50	=	5.2	5.2	-1348	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	475	13	4	5	3.1	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)Cc3ccccc3)cc2)c1	10.1016/j.ejmech.2018.03.032
	24824225	12827	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	454	11	3	5	4.4	CN(c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1)c1ccc(OCC(=O)O)cc1	10.1021/jm701324c
	CHEMBL1188359	12827	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	454	11	3	5	4.4	CN(c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1)c1ccc(OCC(=O)O)cc1	10.1021/jm701324c
	CHEMBL536108	12827	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	454	11	3	5	4.4	CN(c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1)c1ccc(OCC(=O)O)cc1	10.1021/jm701324c
	10092953	98088	None	0	Human	Functional	pEC50	=	7.2	7.2	-34	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	409	8	3	3	4.9	Cc1cc(C(=O)O)ccc1-c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1	10.1021/jm701324c
	CHEMBL273028	98088	None	0	Human	Functional	pEC50	=	7.2	7.2	-34	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	409	8	3	3	4.9	Cc1cc(C(=O)O)ccc1-c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1	10.1021/jm701324c
	16049376	64122	None	0	Human	Functional	pEC50	=	7.2	7.2	-44	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	515	13	5	7	4.2	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3cccc(Cl)c3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807871	64122	None	0	Human	Functional	pEC50	=	7.2	7.2	-44	3	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	515	13	5	7	4.2	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3cccc(Cl)c3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	10238776	66497	None	0	Human	Functional	pEC50	=	7.2	7.2	-79	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	473	17	6	6	3.6	NC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835853	66497	None	0	Human	Functional	pEC50	=	7.2	7.2	-79	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	473	17	6	6	3.6	NC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852214	66497	None	0	Human	Functional	pEC50	=	7.2	7.2	-79	4	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	473	17	6	6	3.6	NC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	24900689	70387	None	0	Human	Functional	pEC50	=	7.2	7.2	-112	5	Binding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assayBinding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assay	ChEMBL	479	11	5	7	3.5	COc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1	10.1016/j.bmcl.2011.10.049
	CHEMBL1945039	70387	None	0	Human	Functional	pEC50	=	7.2	7.2	-112	5	Binding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assayBinding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assay	ChEMBL	479	11	5	7	3.5	COc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1	10.1016/j.bmcl.2011.10.049
	11002571	48113	None	0	Human	Functional	pEC50	=	6.2	6.2	1	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	348	8	4	4	3.2	C[C@H](CNc1ccc(C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL155092	48113	None	0	Human	Functional	pEC50	=	6.2	6.2	1	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	348	8	4	4	3.2	C[C@H](CNc1ccc(C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	10346448	119894	None	0	Human	Functional	pEC50	=	6.2	6.2	-891	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	515	11	4	6	3.8	Cc1ccc(S(=O)(=O)NC(=O)Cc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm0101500
	CHEMBL348501	119894	None	0	Human	Functional	pEC50	=	6.2	6.2	-891	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	515	11	4	6	3.8	Cc1ccc(S(=O)(=O)NC(=O)Cc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm0101500
	11647543	138323	None	0	Human	Functional	pEC50	=	6.2	6.2	-2511	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	424	9	4	4	4.8	C[C@H](CNc1cccc(-c2ccccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	CHEMBL377028	138323	None	0	Human	Functional	pEC50	=	6.2	6.2	-2511	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	424	9	4	4	4.8	C[C@H](CNc1cccc(-c2ccccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	145987168	167311	None	0	Human	Functional	pEC50	=	6.2	6.2	-316	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	4	5	2.1	COc1cccc(CCNC(CO)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2018.04.041
	CHEMBL4291941	167311	None	0	Human	Functional	pEC50	=	6.2	6.2	-316	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	4	5	2.1	COc1cccc(CCNC(CO)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2018.04.041
	42625897	12480	None	0	Human	Functional	pEC50	=	6.2	6.2	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	564	18	4	8	3.1	O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCOCC1	10.1021/jm801016j
	CHEMBL1186265	12480	None	0	Human	Functional	pEC50	=	6.2	6.2	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	564	18	4	8	3.1	O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCOCC1	10.1021/jm801016j
	CHEMBL456485	12480	None	0	Human	Functional	pEC50	=	6.2	6.2	-501	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	564	18	4	8	3.1	O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCOCC1	10.1021/jm801016j
	42625821	12548	None	0	Human	Functional	pEC50	=	6.2	6.2	-630	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	522	18	4	7	3.4	CN(C)S(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1186678	12548	None	0	Human	Functional	pEC50	=	6.2	6.2	-630	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	522	18	4	7	3.4	CN(C)S(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL474393	12548	None	0	Human	Functional	pEC50	=	6.2	6.2	-630	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	522	18	4	7	3.4	CN(C)S(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	44237614	58251	None	0	Rat	Functional	pEC50	=	5.2	5.2	-31622	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	490	9	6	5	3.6	O=C(NCc1ccc(F)cc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682216	58251	None	0	Rat	Functional	pEC50	=	5.2	5.2	-31622	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	490	9	6	5	3.6	O=C(NCc1ccc(F)cc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	44331444	4271	None	0	Human	Functional	pEC50	=	5.2	5.2	-524	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	709	13	5	8	4.2	CC(C)N(Cc1cc(F)ccc1F)C(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1	10.1016/s0960-894x(02)00608-x
	CHEMBL100589	4271	None	0	Human	Functional	pEC50	=	5.2	5.2	-524	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	709	13	5	8	4.2	CC(C)N(Cc1cc(F)ccc1F)C(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1	10.1016/s0960-894x(02)00608-x
	24824226	97496	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	439	11	3	4	4.3	O=C(O)COc1ccc(Cc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	CHEMBL270027	97496	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	439	11	3	4	4.3	O=C(O)COc1ccc(Cc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	44579925	184431	None	0	Human	Functional	pEC50	=	7.2	7.2	-6	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	445	9	3	4	5.4	O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)ccc1Cl	10.1016/j.bmcl.2008.08.009
	CHEMBL484265	184431	None	0	Human	Functional	pEC50	=	7.2	7.2	-6	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	445	9	3	4	5.4	O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)ccc1Cl	10.1016/j.bmcl.2008.08.009
	45483849	199633	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	388	6	3	3	4.5	CC(C)(Cc1cc(F)cc(F)c1)NCC(O)c1cc(Cl)c(N)c(Cl)c1	10.1016/j.bmcl.2009.10.013
	CHEMBL568060	199633	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	388	6	3	3	4.5	CC(C)(Cc1cc(F)cc(F)c1)NCC(O)c1cc(Cl)c(N)c(Cl)c1	10.1016/j.bmcl.2009.10.013
	24936488	17656	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	414	7	3	8	2.7	Cc1csc2ncnc(N3CCC(NCC(O)COc4ccc(O)cc4)CC3)c12	10.1016/j.bmcl.2010.08.039
	CHEMBL1258373	17656	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	414	7	3	8	2.7	Cc1csc2ncnc(N3CCC(NCC(O)COc4ccc(O)cc4)CC3)c12	10.1016/j.bmcl.2010.08.039
	44574759	178673	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	470	12	3	6	3.6	O=C(Cc1nccn1-c1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL467082	178673	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	470	12	3	6	3.6	O=C(Cc1nccn1-c1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	24950570	175534	None	0	Human	Functional	pEC50	=	6.2	6.2	-794	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	439	6	3	3	5.0	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)cc1F	10.1021/jm800222k
	CHEMBL457629	175534	None	0	Human	Functional	pEC50	=	6.2	6.2	-794	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	439	6	3	3	5.0	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)cc1F	10.1021/jm800222k
	44396532	66777	None	0	Human	Functional	pEC50	=	7.2	7.2	-42	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	455	9	4	5	4.3	C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	CHEMBL185836	66777	None	0	Human	Functional	pEC50	=	7.2	7.2	-42	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	455	9	4	5	4.3	C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	44127478	197670	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	435	11	5	6	2.6	NC(C(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1	10.1016/j.ejmech.2009.01.022
	CHEMBL550743	197670	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	435	11	5	6	2.6	NC(C(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1	10.1016/j.ejmech.2009.01.022
	2419	3463	None	53	Human	Functional	pEC50	=	7.2	7.2	-977	19	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/acs.jmedchem.0c01195
	5152	3463	None	53	Human	Functional	pEC50	=	7.2	7.2	-977	19	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/acs.jmedchem.0c01195
	5152.0	3463	None	53	Human	Functional	pEC50	=	7.2	7.2	-977	19	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/acs.jmedchem.0c01195
	559	3463	None	53	Human	Functional	pEC50	=	7.2	7.2	-977	19	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/acs.jmedchem.0c01195
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	7.2	7.2	-977	19	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/acs.jmedchem.0c01195
	DB00938	3463	None	53	Human	Functional	pEC50	=	7.2	7.2	-977	19	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/acs.jmedchem.0c01195
	24950053	188093	None	0	Human	Functional	pEC50	=	6.2	6.2	-117	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	443	7	3	5	5.1	O=C(O)c1ccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)s1	10.1021/jm800222k
	CHEMBL497280	188093	None	0	Human	Functional	pEC50	=	6.2	6.2	-117	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	443	7	3	5	5.1	O=C(O)c1ccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)s1	10.1021/jm800222k
	24950236	189181	None	0	Human	Functional	pEC50	=	7.2	7.2	-89	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	534	9	4	5	6.8	O=C(O)c1cc(NC2CCCCC2)cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)c1	10.1021/jm800222k
	CHEMBL509729	189181	None	0	Human	Functional	pEC50	=	7.2	7.2	-89	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	534	9	4	5	6.8	O=C(O)c1cc(NC2CCCCC2)cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)c1	10.1021/jm800222k
	44579649	187073	None	0	Human	Functional	pEC50	=	6.2	6.2	-12	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	408	10	3	6	3.4	COc1ccc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	CHEMBL490415	187073	None	0	Human	Functional	pEC50	=	6.2	6.2	-12	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	408	10	3	6	3.4	COc1ccc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	11224275	173598	None	0	Human	Functional	pEC50	=	6.2	6.2	-1621	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	433	11	3	4	5.1	CCCOc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL453048	173598	None	0	Human	Functional	pEC50	=	6.2	6.2	-1621	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	433	11	3	4	5.1	CCCOc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	45483839	199389	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	380	7	3	3	4.8	CCc1ccc(CC(C)(C)NCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1	10.1016/j.bmcl.2009.10.013
	CHEMBL566353	199389	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	380	7	3	3	4.8	CCc1ccc(CC(C)(C)NCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1	10.1016/j.bmcl.2009.10.013
	45483852	199213	None	0	Human	Functional	pEC50	=	8.1	8.1	-14	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	392	6	4	5	2.6	CC(C)(Cc1cc(F)cc(F)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL565267	199213	None	0	Human	Functional	pEC50	=	8.1	8.1	-14	2	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	392	6	4	5	2.6	CC(C)(Cc1cc(F)cc(F)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	155564766	175593	None	0	Human	Functional	pEC50	=	8.1	8.1	-181	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	CHEMBL4577508	175593	None	0	Human	Functional	pEC50	=	8.1	8.1	-181	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	12578	936	None	44	Human	Functional	pEC50	=	8.1	8.1	154	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	219	4	3	4	1.2	CC(C)NCC(C1=CC(=C(C=C1)N)C#N)O	10.1021/jm400348g
	2755	936	None	44	Human	Functional	pEC50	=	8.1	8.1	154	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	219	4	3	4	1.2	CC(C)NCC(C1=CC(=C(C=C1)N)C#N)O	10.1021/jm400348g
	CHEMBL1374751	936	None	44	Human	Functional	pEC50	=	8.1	8.1	154	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	219	4	3	4	1.2	CC(C)NCC(C1=CC(=C(C=C1)N)C#N)O	10.1021/jm400348g
	164620479	188651	None	0	Human	Functional	pEC50	=	8.1	8.1	-288	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4863847	188651	None	0	Human	Functional	pEC50	=	8.1	8.1	-288	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028596	188651	None	0	Human	Functional	pEC50	=	8.1	8.1	-288	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	145985242	165640	None	0	Human	Functional	pEC50	=	8.1	8.1	-6	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	443	11	4	4	3.9	O=C(Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1	10.1016/j.ejmech.2018.03.032
	CHEMBL4241613	165640	None	0	Human	Functional	pEC50	=	8.1	8.1	-6	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	443	11	4	4	3.9	O=C(Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1	10.1016/j.ejmech.2018.03.032
	164617235	188626	None	0	Human	Functional	pEC50	=	8.1	8.1	-251	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4848775	188626	None	0	Human	Functional	pEC50	=	8.1	8.1	-251	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028422	188626	None	0	Human	Functional	pEC50	=	8.1	8.1	-251	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	11810896	119546	None	0	Human	Functional	pEC50	=	8.1	8.1	-2	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	375	9	4	4	3.1	CC(=O)NCc1ccc(NC[C@@H](C)NC[C@H](O)c2cccc(Cl)c2)cc1	10.1021/jm0101500
	CHEMBL345304	119546	None	0	Human	Functional	pEC50	=	8.1	8.1	-2	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	375	9	4	4	3.1	CC(=O)NCc1ccc(NC[C@@H](C)NC[C@H](O)c2cccc(Cl)c2)cc1	10.1021/jm0101500
	1499	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.05.064
	3779	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.05.064
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.05.064
	536	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.05.064
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.05.064
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.05.064
	9871386	112334	None	3	Human	Functional	pEC50	=	8.1	8.1	-35	4	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3290999	112334	None	3	Human	Functional	pEC50	=	8.1	8.1	-35	4	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	66796015	112523	None	0	Human	Functional	pEC50	=	8.1	8.1	-35	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	474	11	6	7	3.2	NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298328	112523	None	0	Human	Functional	pEC50	=	8.1	8.1	-35	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	474	11	6	7	3.2	NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	56943518	112524	None	0	Human	Functional	pEC50	=	8.1	8.1	-25	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	488	12	6	7	3.6	NCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298329	112524	None	0	Human	Functional	pEC50	=	8.1	8.1	-25	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	488	12	6	7	3.6	NCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	56943545	112525	None	0	Human	Functional	pEC50	=	8.1	8.1	-28	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	13	6	7	4.0	NCCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298330	112525	None	0	Human	Functional	pEC50	=	8.1	8.1	-28	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	13	6	7	4.0	NCCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	56943546	112541	None	0	Human	Functional	pEC50	=	8.1	8.1	-25	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	518	14	6	8	3.2	NCCOCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298691	112541	None	0	Human	Functional	pEC50	=	8.1	8.1	-25	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	518	14	6	8	3.2	NCCOCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	56943517	112567	None	0	Human	Functional	pEC50	=	8.1	8.1	-3	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	621	13	5	9	2.8	CS(=O)(=O)N1CCN(CCOc2ccc(Nc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)ccc45)cc3)cc2)CC1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298832	112567	None	0	Human	Functional	pEC50	=	8.1	8.1	-3	3	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	621	13	5	9	2.8	CS(=O)(=O)N1CCN(CCOc2ccc(Nc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)ccc45)cc3)cc2)CC1	10.1016/j.bmcl.2014.04.095
	1499	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.08.043
	3779	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.08.043
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.08.043
	536	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.08.043
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.08.043
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2011.08.043
	56678973	66600	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	555	18	6	6	5.6	O=C(Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCCC1	10.1016/j.bmc.2011.08.043
	CHEMBL1835855	66600	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	555	18	6	6	5.6	O=C(Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCCC1	10.1016/j.bmc.2011.08.043
	CHEMBL1852541	66600	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	555	18	6	6	5.6	O=C(Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCCC1	10.1016/j.bmc.2011.08.043
	56658407	66659	None	0	Human	Functional	pEC50	=	8.1	8.1	-15	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	18	6	6	3.3	NC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835857	66659	None	0	Human	Functional	pEC50	=	8.1	8.1	-15	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	18	6	6	3.3	NC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852796	66659	None	0	Human	Functional	pEC50	=	8.1	8.1	-15	3	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	18	6	6	3.3	NC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	1499	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm801016j
	3779	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm801016j
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm801016j
	536	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm801016j
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm801016j
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm801016j
	1499	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm100326d
	3779	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm100326d
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm100326d
	536	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm100326d
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm100326d
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-58	38	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm100326d
	10225563	14214	None	0	Human	Functional	pEC50	=	8.1	8.1	-19	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	445	16	4	6	3.9	Cc1cc(C)cc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL1084891	14214	None	0	Human	Functional	pEC50	=	8.1	8.1	-19	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	445	16	4	6	3.9	Cc1cc(C)cc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL1198889	14214	None	0	Human	Functional	pEC50	=	8.1	8.1	-19	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	445	16	4	6	3.9	Cc1cc(C)cc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	9871386	112334	None	3	Human	Functional	pEC50	=	8.1	8.1	-35	4	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	CHEMBL3290999	112334	None	3	Human	Functional	pEC50	=	8.1	8.1	-35	4	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	45271517	197298	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	499	10	4	4	4.8	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Br)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203998	197298	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	499	10	4	4	4.8	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Br)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL549487	197298	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	499	10	4	4	4.8	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Br)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	45272431	197481	None	0	Human	Functional	pEC50	=	7.2	7.2	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	547	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(I)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204002	197481	None	0	Human	Functional	pEC50	=	7.2	7.2	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	547	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(I)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL549960	197481	None	0	Human	Functional	pEC50	=	7.2	7.2	-6	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	547	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(I)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	44517694	197627	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	451	11	4	5	4.1	COc1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1	10.1016/j.bmc.2009.06.031
	CHEMBL1203996	197627	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	451	11	4	5	4.1	COc1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1	10.1016/j.bmc.2009.06.031
	CHEMBL550445	197627	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	451	11	4	5	4.1	COc1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1	10.1016/j.bmc.2009.06.031
	44517696	198227	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	451	11	4	5	4.1	COc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204007	198227	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	451	11	4	5	4.1	COc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL557705	198227	None	0	Human	Functional	pEC50	=	7.2	7.2	-3	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	451	11	4	5	4.1	COc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	24949891	188274	None	0	Human	Functional	pEC50	=	7.2	7.2	-46	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	438	7	3	5	4.4	O=C(O)c1ccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)nc1	10.1021/jm800222k
	CHEMBL498703	188274	None	0	Human	Functional	pEC50	=	7.2	7.2	-46	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	438	7	3	5	4.4	O=C(O)c1ccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)nc1	10.1021/jm800222k
	24937269	17654	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	490	9	3	8	3.8	OCc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1	10.1016/j.bmcl.2010.08.039
	CHEMBL1258371	17654	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	490	9	3	8	3.8	OCc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1	10.1016/j.bmcl.2010.08.039
	44127481	198608	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	450	12	4	6	3.2	COc1cccc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)c1	10.1016/j.ejmech.2009.01.022
	CHEMBL561211	198608	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	450	12	4	6	3.2	COc1cccc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)c1	10.1016/j.ejmech.2009.01.022
	11189433	203340	None	0	Human	Functional	pEC50	=	6.2	6.2	-57	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	424	6	4	5	3.4	CC(C)(Cc1ccc(C(F)(F)F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL601430	203340	None	0	Human	Functional	pEC50	=	6.2	6.2	-57	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	424	6	4	5	3.4	CC(C)(Cc1ccc(C(F)(F)F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	44396779	67082	None	0	Human	Functional	pEC50	=	7.1	7.1	-17	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	611	12	4	8	5.1	C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3ccccc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	CHEMBL187209	67082	None	0	Human	Functional	pEC50	=	7.1	7.1	-17	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	611	12	4	8	5.1	C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3ccccc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	155551133	174100	None	0	Human	Functional	pEC50	=	7.1	7.1	-446	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	340	7	4	5	1.9	O=c1ccc2c(C(O)CNCCOc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4542430	174100	None	0	Human	Functional	pEC50	=	7.1	7.1	-446	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	340	7	4	5	1.9	O=c1ccc2c(C(O)CNCCOc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	24823127	97996	None	0	Human	Functional	pEC50	=	6.1	6.1	-724	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	453	10	3	4	5.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm701324c
	CHEMBL272584	97996	None	0	Human	Functional	pEC50	=	6.1	6.1	-724	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	453	10	3	4	5.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm701324c
	24823127	97996	None	0	Human	Functional	pEC50	=	6.1	6.1	-724	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	453	10	3	4	5.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1016/j.bmcl.2008.08.009
	CHEMBL272584	97996	None	0	Human	Functional	pEC50	=	6.1	6.1	-724	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	453	10	3	4	5.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1016/j.bmcl.2008.08.009
	44127050	199129	None	0	Human	Functional	pEC50	=	6.1	6.1	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	454	11	4	5	3.8	O=C(Cc1ccccc1Cl)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL564544	199129	None	0	Human	Functional	pEC50	=	6.1	6.1	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	454	11	4	5	3.8	O=C(Cc1ccccc1Cl)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	24823127	97996	None	0	Human	Functional	pEC50	=	6.1	6.1	-724	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	453	10	3	4	5.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL272584	97996	None	0	Human	Functional	pEC50	=	6.1	6.1	-724	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	453	10	3	4	5.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	24823127	97996	None	0	Human	Functional	pEC50	=	6.1	6.1	-724	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	453	10	3	4	5.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm9000709
	CHEMBL272584	97996	None	0	Human	Functional	pEC50	=	6.1	6.1	-724	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	453	10	3	4	5.4	CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm9000709
	44589400	194689	None	0	Human	Functional	pEC50	=	5.1	5.1	-3	3	Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor	ChEMBL	446	11	2	5	4.2	COc1ccc(CCNCC(O)COc2ccc3c(c2)CCCN3Cc2ccccc2)cc1	10.1016/j.bmc.2008.11.030
	CHEMBL530556	194689	None	0	Human	Functional	pEC50	=	5.1	5.1	-3	3	Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor	ChEMBL	446	11	2	5	4.2	COc1ccc(CCNCC(O)COc2ccc3c(c2)CCCN3Cc2ccccc2)cc1	10.1016/j.bmc.2008.11.030
	45271886	197771	None	0	Human	Functional	pEC50	=	7.1	7.1	-724	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	ChEMBL	508	11	3	5	4.5	CC(C)Cc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1016/j.bmcl.2009.06.083
	CHEMBL551532	197771	None	0	Human	Functional	pEC50	=	7.1	7.1	-724	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	ChEMBL	508	11	3	5	4.5	CC(C)Cc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1016/j.bmcl.2009.06.083
	42639806	12522	None	0	Human	Functional	pEC50	=	6.1	6.1	-40	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	468	10	3	6	2.9	COc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL1186584	12522	None	0	Human	Functional	pEC50	=	6.1	6.1	-40	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	468	10	3	6	2.9	COc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL470858	12522	None	0	Human	Functional	pEC50	=	6.1	6.1	-40	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	468	10	3	6	2.9	COc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	44331346	210848	None	0	Human	Functional	pEC50	=	6.1	6.1	-120	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	638	17	5	8	4.2	CCCCCCCCC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1	10.1016/s0960-894x(02)00608-x
	CHEMBL99599	210848	None	0	Human	Functional	pEC50	=	6.1	6.1	-120	3	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	638	17	5	8	4.2	CCCCCCCCC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1	10.1016/s0960-894x(02)00608-x
	172461665	196598	None	0	Human	Functional	pEC50	=	7.1	7.1	134	3	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	366	7	2	6	2.4	O[C@@H](CNCC1COc2ccccc2O1)COc1cccc2cnccc12	10.1016/j.ejmech.2022.114961
	CHEMBL5427527	196598	None	0	Human	Functional	pEC50	=	7.1	7.1	134	3	Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation	ChEMBL	366	7	2	6	2.4	O[C@@H](CNCC1COc2ccccc2O1)COc1cccc2cnccc12	10.1016/j.ejmech.2022.114961
	44560791	189205	None	0	Human	Functional	pEC50	=	7.1	7.1	-154	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	376	8	3	4	3.7	C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccnc1	10.1021/jm8000345
	CHEMBL510102	189205	None	0	Human	Functional	pEC50	=	7.1	7.1	-154	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	376	8	3	4	3.7	C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccnc1	10.1021/jm8000345
	42639808	12529	None	0	Human	Functional	pEC50	=	6.1	6.1	-1230	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	522	11	3	6	4.2	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCC1	10.1021/jm9000709
	CHEMBL1186601	12529	None	0	Human	Functional	pEC50	=	6.1	6.1	-1230	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	522	11	3	6	4.2	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCC1	10.1021/jm9000709
	CHEMBL472090	12529	None	0	Human	Functional	pEC50	=	6.1	6.1	-1230	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	522	11	3	6	4.2	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCC1	10.1021/jm9000709
	10302915	5350	None	0	Human	Functional	pEC50	=	6.1	6.1	-23	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	554	12	5	6	4.0	O=C(NCc1c(F)cccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL106884	5350	None	0	Human	Functional	pEC50	=	6.1	6.1	-23	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	554	12	5	6	4.0	O=C(NCc1c(F)cccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	44127681	197672	None	0	Human	Functional	pEC50	=	6.1	6.1	2	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	420	11	4	5	3.1	O=C(Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL550746	197672	None	0	Human	Functional	pEC50	=	6.1	6.1	2	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	420	11	4	5	3.1	O=C(Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	164623544	188681	None	0	Human	Functional	pEC50	=	7.1	7.1	-2754	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	406	7	4	4	3.5	O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4872653	188681	None	0	Human	Functional	pEC50	=	7.1	7.1	-2754	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	406	7	4	4	3.5	O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5028764	188681	None	0	Human	Functional	pEC50	=	7.1	7.1	-2754	2	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	406	7	4	4	3.5	O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	24949722	175635	None	0	Human	Functional	pEC50	=	6.1	6.1	-223	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	455	6	3	3	5.3	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(C(F)(F)F)cc2)CC3)cc1	10.1021/jm800222k
	CHEMBL457839	175635	None	0	Human	Functional	pEC50	=	6.1	6.1	-223	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	455	6	3	3	5.3	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(C(F)(F)F)cc2)CC3)cc1	10.1021/jm800222k
	11476004	173597	None	0	Human	Functional	pEC50	=	6.1	6.1	-954	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	433	10	3	4	5.1	CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL453047	173597	None	0	Human	Functional	pEC50	=	6.1	6.1	-954	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	433	10	3	4	5.1	CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	45269853	199024	None	0	Human	Functional	pEC50	=	4.1	4.1	-4	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	426	11	3	5	3.1	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL563872	199024	None	0	Human	Functional	pEC50	=	4.1	4.1	-4	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	ChEMBL	426	11	3	5	3.1	O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1	10.1016/j.bmc.2009.06.031
	9799092	47320	None	0	Human	Functional	pEC50	=	7.1	7.1	-17	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	362	9	4	4	3.1	C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL154419	47320	None	0	Human	Functional	pEC50	=	7.1	7.1	-17	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	362	9	4	4	3.1	C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	9799092	47320	None	0	Human	Functional	pEC50	=	7.1	7.1	-17	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	362	9	4	4	3.1	C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	CHEMBL154419	47320	None	0	Human	Functional	pEC50	=	7.1	7.1	-17	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	362	9	4	4	3.1	C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	56678847	66398	None	0	Human	Functional	pEC50	=	7.1	7.1	-125	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	527	18	5	7	3.2	O=C1CN(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1	10.1016/j.bmc.2011.05.064
	CHEMBL1814274	66398	None	0	Human	Functional	pEC50	=	7.1	7.1	-125	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	527	18	5	7	3.2	O=C1CN(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1	10.1016/j.bmc.2011.05.064
	CHEMBL1851691	66398	None	0	Human	Functional	pEC50	=	7.1	7.1	-125	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	527	18	5	7	3.2	O=C1CN(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1	10.1016/j.bmc.2011.05.064
	56678845	66427	None	0	Human	Functional	pEC50	=	7.1	7.1	-39	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CNC(=O)N1c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1016/j.bmc.2011.05.064
	CHEMBL1814269	66427	None	0	Human	Functional	pEC50	=	7.1	7.1	-39	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CNC(=O)N1c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1016/j.bmc.2011.05.064
	CHEMBL1851839	66427	None	0	Human	Functional	pEC50	=	7.1	7.1	-39	3	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CNC(=O)N1c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1016/j.bmc.2011.05.064
	9871096	66671	None	0	Human	Functional	pEC50	=	7.1	7.1	-125	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CNC(=O)N1c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814268	66671	None	0	Human	Functional	pEC50	=	7.1	7.1	-125	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CNC(=O)N1c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1852860	66671	None	0	Human	Functional	pEC50	=	7.1	7.1	-125	4	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	513	17	5	7	3.2	O=C1CNC(=O)N1c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	9799092	47320	None	0	Human	Functional	pEC50	=	7.1	7.1	-17	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	362	9	4	4	3.1	C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL154419	47320	None	0	Human	Functional	pEC50	=	7.1	7.1	-17	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	362	9	4	4	3.1	C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	44441229	93802	None	0	Human	Functional	pEC50	=	7.1	7.1	-100	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	431	9	4	6	4.3	C[C@H](CNc1cccc(-c2nc(C(=O)O)cs2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL247315	93802	None	0	Human	Functional	pEC50	=	7.1	7.1	-100	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	431	9	4	6	4.3	C[C@H](CNc1cccc(-c2nc(C(=O)O)cs2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	46833103	7415	None	0	Human	Functional	pEC50	=	7.1	7.1	-10	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	433	16	5	7	3.0	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2ccc(O)cc2)ccc1O	10.1021/jm100326d
	CHEMBL1086535	7415	None	0	Human	Functional	pEC50	=	7.1	7.1	-10	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	433	16	5	7	3.0	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2ccc(O)cc2)ccc1O	10.1021/jm100326d
	11060184	119794	None	0	Human	Functional	pEC50	=	6.1	6.1	-1000	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	501	11	4	6	3.5	C[C@H](CNc1ccc(CC(=O)NS(=O)(=O)c2ccccc2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL347616	119794	None	0	Human	Functional	pEC50	=	6.1	6.1	-1000	3	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	501	11	4	6	3.5	C[C@H](CNc1ccc(CC(=O)NS(=O)(=O)c2ccccc2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	9823696	75802	None	0	Human	Functional	pEC50	=	6.1	6.1	-501	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	424	9	4	4	4.7	Cc1ccc(C(=O)O)cc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1	10.1021/jm0509445
	CHEMBL204827	75802	None	0	Human	Functional	pEC50	=	6.1	6.1	-501	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	424	9	4	4	4.7	Cc1ccc(C(=O)O)cc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1	10.1021/jm0509445
	11495581	77351	None	0	Human	Functional	pEC50	=	6.1	6.1	-25	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	425	9	4	5	4.2	C[C@H](CNc1cccc(-c2ncccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	CHEMBL208328	77351	None	0	Human	Functional	pEC50	=	6.1	6.1	-25	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	425	9	4	5	4.2	C[C@H](CNc1cccc(-c2ncccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	11546349	141420	None	0	Human	Functional	pEC50	=	6.1	6.1	-25	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	424	9	4	4	4.8	C[C@H](CNc1cccc(-c2ccc(C(=O)O)cc2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	CHEMBL383511	141420	None	0	Human	Functional	pEC50	=	6.1	6.1	-25	3	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	424	9	4	4	4.8	C[C@H](CNc1cccc(-c2ccc(C(=O)O)cc2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0509445
	2419	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.05.097
	5152	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.05.097
	5152.0	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.05.097
	559	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.05.097
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.05.097
	DB00938	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2011.05.097
	2419	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	5152	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	5152.0	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	559	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	DB00938	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	2419	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	5152	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	5152.0	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	559	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	DB00938	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	2419	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	5152	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	5152.0	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	559	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	DB00938	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	2419	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	5152	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	5152.0	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	559	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	CHEMBL1263	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	DB00938	3463	None	53	Human	Functional	pEC50	=	6.1	6.1	-977	19	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	10940242	165293	None	0	Human	Functional	pEC50	=	6.1	6.1	-79	3	Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	515	12	4	6	3.8	C[C@H](CNc1ccc(CCS(=O)(=O)NC(=O)c2ccccc2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL422876	165293	None	0	Human	Functional	pEC50	=	6.1	6.1	-79	3	Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	515	12	4	6	3.8	C[C@H](CNc1ccc(CCS(=O)(=O)NC(=O)c2ccccc2)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	42625743	12605	None	0	Human	Functional	pEC50	=	4.1	4.1	-39	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCCCOCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1186943	12605	None	0	Human	Functional	pEC50	=	4.1	4.1	-39	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCCCOCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483407	12605	None	0	Human	Functional	pEC50	=	4.1	4.1	-39	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCCCOCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	559929	4902	None	8	Guinea pig	Functional	pEC50	=	8.1	8.1	4	2	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	273	5	4	5	1.4	CC(C)(C)NCC(O)COc1ccc(O)c(O)c1F	10.1021/jm00107a027
	CHEMBL10453	4902	None	8	Guinea pig	Functional	pEC50	=	8.1	8.1	4	2	Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria	ChEMBL	273	5	4	5	1.4	CC(C)(C)NCC(O)COc1ccc(O)c(O)c1F	10.1021/jm00107a027
	44419332	141847	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levelsAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levels	ChEMBL	505	11	4	8	2.5	Cn1c(=O)[nH]c2cccc(OC[C@@H](O)CNC(C)(C)Cc3ccc(Oc4ccc(C(N)=O)cn4)cc3)c21	10.1016/j.bmcl.2006.08.010
	CHEMBL386016	141847	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	3	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levelsAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levels	ChEMBL	505	11	4	8	2.5	Cn1c(=O)[nH]c2cccc(OC[C@@H](O)CNC(C)(C)Cc3ccc(Oc4ccc(C(N)=O)cn4)cc3)c21	10.1016/j.bmcl.2006.08.010
	46889771	6996	None	0	Human	Functional	pEC50	=	7.1	7.1	1	3	Agonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayAgonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assay	ChEMBL	549	7	3	6	4.9	O=C1c2cccc3cc(O)cc(c23)C(=O)N1CC1CCN(CC(O)COc2cccc3[nH]c4ccccc4c23)CC1	10.1016/j.bmcl.2010.04.009
	CHEMBL1084706	6996	None	0	Human	Functional	pEC50	=	7.1	7.1	1	3	Agonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayAgonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assay	ChEMBL	549	7	3	6	4.9	O=C1c2cccc3cc(O)cc(c23)C(=O)N1CC1CCN(CC(O)COc2cccc3[nH]c4ccccc4c23)CC1	10.1016/j.bmcl.2010.04.009
	45268136	198841	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	466	11	4	6	4.0	O=[N+]([O-])c1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1	10.1016/j.bmc.2009.06.031
	CHEMBL1203989	198841	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	466	11	4	6	4.0	O=[N+]([O-])c1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1	10.1016/j.bmc.2009.06.031
	CHEMBL562669	198841	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	466	11	4	6	4.0	O=[N+]([O-])c1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1	10.1016/j.bmc.2009.06.031
	44560792	173492	None	0	Human	Functional	pEC50	=	7.1	7.1	-794	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	434	10	3	5	4.5	CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccnc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL452798	173492	None	0	Human	Functional	pEC50	=	7.1	7.1	-794	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	434	10	3	5	4.5	CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccnc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	24950718	176102	None	0	Human	Functional	pEC50	=	6.1	6.1	-398	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	435	6	3	3	5.2	Cc1cc(C(=O)O)ccc1-c1ccc2c(c1)C[C@@H](NC[C@H](O)c1ccc(Cl)cc1)CC2	10.1021/jm800222k
	CHEMBL458927	176102	None	0	Human	Functional	pEC50	=	6.1	6.1	-398	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	435	6	3	3	5.2	Cc1cc(C(=O)O)ccc1-c1ccc2c(c1)C[C@@H](NC[C@H](O)c1ccc(Cl)cc1)CC2	10.1021/jm800222k
	11272641	12447	None	0	Human	Functional	pEC50	=	6.1	6.1	-6165	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	537	11	3	7	4.0	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	CHEMBL1186009	12447	None	0	Human	Functional	pEC50	=	6.1	6.1	-6165	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	537	11	3	7	4.0	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	CHEMBL445481	12447	None	0	Human	Functional	pEC50	=	6.1	6.1	-6165	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	537	11	3	7	4.0	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1	10.1021/jm9000709
	25071020	193294	None	0	Human	Functional	pEC50	=	6.1	6.1	-251	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	469	11	3	5	5.5	CC(C)Oc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	CHEMBL523265	193294	None	0	Human	Functional	pEC50	=	6.1	6.1	-251	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	469	11	3	5	5.5	CC(C)Oc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O	10.1016/j.bmcl.2008.08.009
	24949726	189649	None	0	Human	Functional	pEC50	=	6.1	6.1	-457	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	435	6	3	3	5.2	Cc1cc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)ccc1C(=O)O	10.1021/jm800222k
	CHEMBL514265	189649	None	0	Human	Functional	pEC50	=	6.1	6.1	-457	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	435	6	3	3	5.2	Cc1cc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)ccc1C(=O)O	10.1021/jm800222k
	44127479	198635	None	0	Human	Functional	pEC50	=	7.1	7.1	10	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	454	11	4	5	3.8	O=C(Cc1cccc(Cl)c1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL561348	198635	None	0	Human	Functional	pEC50	=	7.1	7.1	10	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	454	11	4	5	3.8	O=C(Cc1cccc(Cl)c1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	24895359	192603	None	0	Human	Functional	pEC50	=	7.1	7.1	-104	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	405	9	3	4	4.3	COc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL520903	192603	None	0	Human	Functional	pEC50	=	7.1	7.1	-104	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	405	9	3	4	4.3	COc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	145989075	167188	None	0	Human	Functional	pEC50	=	6.1	6.1	-524	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	324	6	4	4	2.1	O=c1ccc2c(C(CO)NCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2018.04.041
	CHEMBL4289813	167188	None	0	Human	Functional	pEC50	=	6.1	6.1	-524	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	324	6	4	4	2.1	O=c1ccc2c(C(CO)NCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2018.04.041
	145994130	167477	None	0	Human	Functional	pEC50	=	6.1	6.1	-83	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	338	7	4	4	2.5	O=c1ccc2c(C(CO)NCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2018.04.041
	CHEMBL4294937	167477	None	0	Human	Functional	pEC50	=	6.1	6.1	-83	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	338	7	4	4	2.5	O=c1ccc2c(C(CO)NCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2018.04.041
	24894315	173076	None	0	Human	Functional	pEC50	=	7.1	7.1	-165	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	469	11	3	5	5.2	CC(C)Oc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL451772	173076	None	0	Human	Functional	pEC50	=	7.1	7.1	-165	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	469	11	3	5	5.2	CC(C)Oc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O	10.1021/jm8000345
	44580042	193208	None	0	Human	Functional	pEC50	=	6.1	6.1	-26	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	396	9	3	5	3.6	O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)ccc1F	10.1016/j.bmcl.2008.08.009
	CHEMBL522641	193208	None	0	Human	Functional	pEC50	=	6.1	6.1	-26	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	396	9	3	5	3.6	O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)ccc1F	10.1016/j.bmcl.2008.08.009
	42639491	12575	None	0	Human	Functional	pEC50	=	6.1	6.1	-1659	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	552	11	3	6	5.3	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1SC1CCCCC1	10.1021/jm9000709
	CHEMBL1186805	12575	None	0	Human	Functional	pEC50	=	6.1	6.1	-1659	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	552	11	3	6	5.3	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1SC1CCCCC1	10.1021/jm9000709
	CHEMBL479342	12575	None	0	Human	Functional	pEC50	=	6.1	6.1	-1659	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	552	11	3	6	5.3	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1SC1CCCCC1	10.1021/jm9000709
	44396738	123951	None	0	Human	Functional	pEC50	=	7.1	7.1	-77	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	655	13	5	9	4.8	C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3ccc(C(=O)O)cc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	CHEMBL362763	123951	None	0	Human	Functional	pEC50	=	7.1	7.1	-77	3	Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor	ChEMBL	655	13	5	9	4.8	C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3ccc(C(=O)O)cc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2004.10.035
	10142284	4891	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	510	11	5	6	3.9	O=C(NC1CCCCC1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL104481	4891	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	510	11	5	6	3.9	O=C(NC1CCCCC1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	1239	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.10.013
	3410	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.10.013
	3410.0	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.10.013
	3465	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.10.013
	CHEMBL1256786	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.10.013
	DB00983	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.10.013
	1239	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.06.104
	3410	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.06.104
	3410.0	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.06.104
	3465	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.06.104
	CHEMBL1256786	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.06.104
	DB00983	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.06.104
	1239	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.12.087
	3410	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.12.087
	3410.0	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.12.087
	3465	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.12.087
	CHEMBL1256786	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.12.087
	DB00983	1677	None	37	Human	Functional	pEC50	=	7.1	7.1	-67	6	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2009.12.087
	24895361	185480	None	0	Human	Functional	pEC50	=	7.1	7.1	-933	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	433	10	3	4	5.1	CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	CHEMBL486051	185480	None	0	Human	Functional	pEC50	=	7.1	7.1	-933	3	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	433	10	3	4	5.1	CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O	10.1021/jm8000345
	155550964	174054	None	0	Human	Functional	pEC50	=	7.1	7.1	-575	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	352	8	4	4	2.9	O=c1ccc2c(C(O)CNCCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4541263	174054	None	0	Human	Functional	pEC50	=	7.1	7.1	-575	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	352	8	4	4	2.9	O=c1ccc2c(C(O)CNCCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	10232593	5399	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	609	17	6	7	4.8	CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)c4c3CCC(=O)N4)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL107129	5399	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	609	17	6	7	4.8	CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)c4c3CCC(=O)N4)cc2)CC1	10.1016/s0960-894x(01)00645-x
	9873245	4518	None	0	Human	Functional	pEC50	=	6.1	6.1	-38	3	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	590	17	5	7	4.3	CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	CHEMBL102194	4518	None	0	Human	Functional	pEC50	=	6.1	6.1	-38	3	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	590	17	5	7	4.3	CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	10028830	2246	None	31	Human	Functional	pEC50	=	6.1	6.1	-186	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	497	13	4	6	2.7	O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1	10.1016/j.ejmech.2018.03.032
	3932	2246	None	31	Human	Functional	pEC50	=	6.1	6.1	-186	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	497	13	4	6	2.7	O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1	10.1016/j.ejmech.2018.03.032
	CHEMBL4238084	2246	None	31	Human	Functional	pEC50	=	6.1	6.1	-186	3	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	497	13	4	6	2.7	O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1	10.1016/j.ejmech.2018.03.032
	44237666	58253	None	0	Rat	Functional	pEC50	=	5.1	5.1	-44668	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	548	10	6	5	5.0	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682218	58253	None	0	Rat	Functional	pEC50	=	5.1	5.1	-44668	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	548	10	6	5	5.0	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2010.12.096
	24950059	174974	None	0	Human	Functional	pEC50	=	6.1	6.1	-169	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	467	8	3	5	5.0	COc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1	10.1021/jm800222k
	CHEMBL456352	174974	None	0	Human	Functional	pEC50	=	6.1	6.1	-169	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	467	8	3	5	5.0	COc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1	10.1021/jm800222k
	24823466	12835	None	0	Human	Functional	pEC50	=	8.0	8.0	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	440	11	4	5	4.4	O=C(O)COc1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	CHEMBL1188436	12835	None	0	Human	Functional	pEC50	=	8.0	8.0	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	440	11	4	5	4.4	O=C(O)COc1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	CHEMBL536330	12835	None	0	Human	Functional	pEC50	=	8.0	8.0	1	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	440	11	4	5	4.4	O=C(O)COc1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1	10.1021/jm701324c
	11270069	95754	None	0	Human	Functional	pEC50	=	8.0	8.0	6	2	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	328	6	3	2	4.1	C[C@@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	CHEMBL25823	95754	None	0	Human	Functional	pEC50	=	8.0	8.0	6	2	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	328	6	3	2	4.1	C[C@@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	52949488	17553	None	0	Human	Functional	pEC50	=	8.0	8.0	-3	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	490	9	2	8	4.4	COc1ccccc1OCC(O)CNC1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1	10.1016/j.bmcl.2010.08.039
	CHEMBL1258023	17553	None	0	Human	Functional	pEC50	=	8.0	8.0	-3	3	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	490	9	2	8	4.4	COc1ccccc1OCC(O)CNC1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1	10.1016/j.bmcl.2010.08.039
	155548071	173853	None	0	Human	Functional	pEC50	=	8.0	8.0	-131	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	338	7	4	4	2.5	O=c1ccc2c(C(O)CNCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4536813	173853	None	0	Human	Functional	pEC50	=	8.0	8.0	-131	2	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	338	7	4	4	2.5	O=c1ccc2c(C(O)CNCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	56598831	89177	None	0	Human	Functional	pEC50	=	8.0	8.0	1023	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	459	15	5	7	2.3	O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	CHEMBL2348220	89177	None	0	Human	Functional	pEC50	=	8.0	8.0	1023	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	459	15	5	7	2.3	O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	CHEMBL2365796	89177	None	0	Human	Functional	pEC50	=	8.0	8.0	1023	3	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	459	15	5	7	2.3	O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	45101522	201473	None	0	Human	Functional	pEC50	=	8	8.0	-5	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	578	15	7	9	2.0	CC(C)(Cc1ccc(NC(=O)CCCNCCCS(=O)(=O)O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL585751	201473	None	0	Human	Functional	pEC50	=	8	8.0	-5	2	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	578	15	7	9	2.0	CC(C)(Cc1ccc(NC(=O)CCCNCCCS(=O)(=O)O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	45272430	197900	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	439	10	4	4	4.2	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(F)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204001	197900	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	439	10	4	4	4.2	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(F)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL552374	197900	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	439	10	4	4	4.2	O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(F)cc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	44517692	199125	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	466	11	4	6	4.0	O=[N+]([O-])c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1203990	199125	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	466	11	4	6	4.0	O=[N+]([O-])c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL564516	199125	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	3	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	466	11	4	6	4.0	O=[N+]([O-])c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	44237612	58246	None	0	Rat	Functional	pEC50	=	6.1	6.1	-4466	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	472	9	6	5	3.4	O=C(NCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682211	58246	None	0	Rat	Functional	pEC50	=	6.1	6.1	-4466	2	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	472	9	6	5	3.4	O=C(NCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	11398536	12479	None	0	Human	Functional	pEC50	=	6.1	6.1	-6309	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	535	11	4	6	4.7	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1NC1CCCCC1	10.1021/jm9000709
	CHEMBL1186241	12479	None	0	Human	Functional	pEC50	=	6.1	6.1	-6309	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	535	11	4	6	4.7	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1NC1CCCCC1	10.1021/jm9000709
	CHEMBL455773	12479	None	0	Human	Functional	pEC50	=	6.1	6.1	-6309	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	535	11	4	6	4.7	CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1NC1CCCCC1	10.1021/jm9000709
	24895565	176800	None	0	Human	Functional	pEC50	=	7.0	7.0	-575	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	475	11	3	5	5.5	O=C(O)c1ccc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1	10.1021/jm8000345
	CHEMBL459862	176800	None	0	Human	Functional	pEC50	=	7.0	7.0	-575	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	475	11	3	5	5.5	O=C(O)c1ccc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1	10.1021/jm8000345
	44127167	198712	None	0	Human	Functional	pEC50	=	6.0	6.0	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	421	11	4	6	2.5	O=C(Cc1cccnc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL561818	198712	None	0	Human	Functional	pEC50	=	6.0	6.0	1	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	421	11	4	6	2.5	O=C(Cc1cccnc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	24949720	189631	None	0	Human	Functional	pEC50	=	6.0	6.0	-2398	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	421	6	3	3	4.9	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)cc1	10.1021/jm800222k
	CHEMBL514102	189631	None	0	Human	Functional	pEC50	=	6.0	6.0	-2398	3	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	421	6	3	3	4.9	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)cc1	10.1021/jm800222k
	44565907	193279	None	0	Human	Functional	pEC50	=	7.0	7.0	-138	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	498	11	4	8	2.3	CCOc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	CHEMBL523149	193279	None	0	Human	Functional	pEC50	=	7.0	7.0	-138	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	498	11	4	8	2.3	CCOc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O	10.1021/jm9000709
	10205463	5504	None	0	Human	Functional	pEC50	=	6.0	6.0	-10	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	470	11	5	6	3.0	CC(C)NC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	CHEMBL107633	5504	None	0	Human	Functional	pEC50	=	6.0	6.0	-10	2	In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor	ChEMBL	470	11	5	6	3.0	CC(C)NC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1	10.1016/s0960-894x(01)00645-x
	44127052	198192	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	450	12	4	6	3.2	COc1ccccc1CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	CHEMBL557269	198192	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	2	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	ChEMBL	450	12	4	6	3.2	COc1ccccc1CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/j.ejmech.2009.01.022
	44574758	178648	None	0	Human	Functional	pEC50	=	5.0	5.0	-18	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	394	11	4	5	2.2	O=C(Cc1ncc[nH]1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	CHEMBL466879	178648	None	0	Human	Functional	pEC50	=	5.0	5.0	-18	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	394	11	4	5	2.2	O=C(Cc1ncc[nH]1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1	10.1016/j.bmc.2009.03.044
	9896817	102940	None	0	Human	Functional	pEC50	=	6.0	6.0	-22	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)c2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL305891	102940	None	0	Human	Functional	pEC50	=	6.0	6.0	-22	3	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)c2)cc1	10.1016/s0960-894x(00)00459-5
	24823296	98085	None	0	Human	Functional	pEC50	=	6.0	6.0	-2884	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	453	10	3	4	5.7	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1Oc1ccccc1	10.1021/jm701324c
	CHEMBL273006	98085	None	0	Human	Functional	pEC50	=	6.0	6.0	-2884	2	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	453	10	3	4	5.7	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1Oc1ccccc1	10.1021/jm701324c
	24949883	176199	None	0	Human	Functional	pEC50	=	6.0	6.0	-691	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	439	6	3	3	5.0	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)c(F)c1	10.1021/jm800222k
	CHEMBL459133	176199	None	0	Human	Functional	pEC50	=	6.0	6.0	-691	2	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	439	6	3	3	5.0	O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)c(F)c1	10.1021/jm800222k
	24823296	98085	None	0	Human	Functional	pEC50	=	6.0	6.0	-2884	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	453	10	3	4	5.7	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1Oc1ccccc1	10.1021/jm9000709
	CHEMBL273006	98085	None	0	Human	Functional	pEC50	=	6.0	6.0	-2884	2	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	453	10	3	4	5.7	O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1Oc1ccccc1	10.1021/jm9000709
	10648298	99773	None	0	Human	Functional	pEC50	=	5.0	5.0	-251	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	477	10	5	7	2.1	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(CCC(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	CHEMBL284788	99773	None	0	Human	Functional	pEC50	=	5.0	5.0	-251	3	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	477	10	5	7	2.1	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(CCC(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	46232815	204138	None	0	Human	Functional	pEC50	=	6	6.0	5	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	412	6	4	5	3.7	CC(C)(Cc1ccc(C(C)(C)C)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL606208	204138	None	0	Human	Functional	pEC50	=	6	6.0	5	2	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	412	6	4	5	3.7	CC(C)(Cc1ccc(C(C)(C)C)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	9896817	102940	None	0	Human	Functional	pIC50	=	5	5.0	-22	3	Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)c2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL305891	102940	None	0	Human	Functional	pIC50	=	5	5.0	-22	3	Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)c2)cc1	10.1016/s0960-894x(00)00459-5
	9962058	207240	None	0	Human	Functional	pIC50	=	4	4.0	-165	3	Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)cc2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL74860	207240	None	0	Human	Functional	pIC50	=	4	4.0	-165	3	Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)cc2)cc1	10.1016/s0960-894x(00)00459-5
	53318280	58672	None	0	Human	Functional	pIC50	=	6.0	6.0	-95	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	623	11	3	6	7.2	O=S(=O)(Nc1ccc(CCNC[C@H](O)c2ccccc2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	CHEMBL1684578	58672	None	0	Human	Functional	pIC50	=	6.0	6.0	-95	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	623	11	3	6	7.2	O=S(=O)(Nc1ccc(CCNC[C@H](O)c2ccccc2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	11722516	90925	None	0	Guinea pig	Functional	pIC50	=	5.9	5.9	-	1	Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs	ChEMBL	303	9	2	4	2.2	COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1	10.1016/S0960-894X(97)00207-2
	CHEMBL23929	90925	None	0	Guinea pig	Functional	pIC50	=	5.9	5.9	-	1	Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs	ChEMBL	303	9	2	4	2.2	COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1	10.1016/S0960-894X(97)00207-2
	44268214	18576	None	0	Human	Functional	pIC50	=	7.8	7.8	4	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	331	10	3	5	2.4	COc1ccc(CCCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/s0960-894x(98)00169-3
	CHEMBL12762	18576	None	0	Human	Functional	pIC50	=	7.8	7.8	4	3	Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor	ChEMBL	331	10	3	5	2.4	COc1ccc(CCCNC[C@H](O)COc2ccc(O)cc2)cc1	10.1016/s0960-894x(98)00169-3
	53319639	58675	None	0	Human	Functional	pIC50	=	5.8	5.8	-1	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(CC2CC[C@H]([C@@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	CHEMBL1684582	58675	None	0	Human	Functional	pIC50	=	5.8	5.8	-1	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(CC2CC[C@H]([C@@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	145990586	166939	None	0	Human	Functional	pIC50	=	7.8	7.8	-1	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells assessed as decrease in isoproterenol-induced cAMP accumulation after 15 mins by HTRF assayAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells assessed as decrease in isoproterenol-induced cAMP accumulation after 15 mins by HTRF assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
	CHEMBL4285281	166939	None	0	Human	Functional	pIC50	=	7.8	7.8	-1	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells assessed as decrease in isoproterenol-induced cAMP accumulation after 15 mins by HTRF assayAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells assessed as decrease in isoproterenol-induced cAMP accumulation after 15 mins by HTRF assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
	53326196	58673	None	0	Human	Functional	pIC50	=	5.8	5.8	1	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(CC2CC[C@@H]([C@@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	CHEMBL1684580	58673	None	0	Human	Functional	pIC50	=	5.8	5.8	1	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(CC2CC[C@@H]([C@@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	567	725	None	16	Rat	Functional	pIC50	=	6.7	6.7	-186	7	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	363	9	3	4	3.1	C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O	10.1021/jm00094a025
	9841972	725	None	16	Rat	Functional	pIC50	=	6.7	6.7	-186	7	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	363	9	3	4	3.1	C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O	10.1021/jm00094a025
	CHEMBL284782	725	None	16	Rat	Functional	pIC50	=	6.7	6.7	-186	7	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	363	9	3	4	3.1	C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O	10.1021/jm00094a025
	1786	2520	None	51	Guinea pig	Functional	pIC50	=	6.7	6.7	-4	7	Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	4171	2520	None	51	Guinea pig	Functional	pIC50	=	6.7	6.7	-4	7	Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	4171.0	2520	None	51	Guinea pig	Functional	pIC50	=	6.7	6.7	-4	7	Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	553	2520	None	51	Guinea pig	Functional	pIC50	=	6.7	6.7	-4	7	Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	CHEMBL13	2520	None	51	Guinea pig	Functional	pIC50	=	6.7	6.7	-4	7	Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	DB00264	2520	None	51	Guinea pig	Functional	pIC50	=	6.7	6.7	-4	7	Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	127034967	136575	None	0	Human	Functional	pIC50	=	6.7	6.7	-1	3	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	260	5	2	4	1.6	CB1C=Cc2c(cccc2OCC(O)CN(C)C)N1	10.1021/acs.jmedchem.5b01088
	CHEMBL3736156	136575	None	0	Human	Functional	pIC50	=	6.7	6.7	-1	3	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	260	5	2	4	1.6	CB1C=Cc2c(cccc2OCC(O)CN(C)C)N1	10.1021/acs.jmedchem.5b01088
	53326839	58674	None	0	Human	Functional	pIC50	=	5.7	5.7	-26	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(CC2CC[C@@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	CHEMBL1684581	58674	None	0	Human	Functional	pIC50	=	5.7	5.7	-26	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(CC2CC[C@@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	11722516	90925	None	0	Guinea pig	Functional	pIC50	=	5.7	5.7	-	1	Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs	ChEMBL	303	9	2	4	2.2	COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1	10.1016/S0960-894X(97)00207-2
	CHEMBL23929	90925	None	0	Guinea pig	Functional	pIC50	=	5.7	5.7	-	1	Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs	ChEMBL	303	9	2	4	2.2	COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1	10.1016/S0960-894X(97)00207-2
	51346867	58676	None	0	Human	Functional	pIC50	=	5.7	5.7	-537	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	CHEMBL1684583	58676	None	0	Human	Functional	pIC50	=	5.7	5.7	-537	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	53326197	58677	None	0	Human	Functional	pIC50	=	6.6	6.6	-28	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(C[C@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	CHEMBL1684584	58677	None	0	Human	Functional	pIC50	=	6.6	6.6	-28	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(C[C@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	2303	3187	None	44	Human	Functional	pIC50	=	6.6	6.6	-6	20	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	4946	3187	None	44	Human	Functional	pIC50	=	6.6	6.6	-6	20	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	564	3187	None	44	Human	Functional	pIC50	=	6.6	6.6	-6	20	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	63	3187	None	44	Human	Functional	pIC50	=	6.6	6.6	-6	20	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	91536	3187	None	44	Human	Functional	pIC50	=	6.6	6.6	-6	20	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	CHEMBL27	3187	None	44	Human	Functional	pIC50	=	6.6	6.6	-6	20	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	CHEMBL452861	3187	None	44	Human	Functional	pIC50	=	6.6	6.6	-6	20	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	DB00571	3187	None	44	Human	Functional	pIC50	=	6.6	6.6	-6	20	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	9873245	4518	None	0	Human	Functional	pIC50	=	7.6	7.6	-38	3	Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorCompound was tested for the antagonistic activity against Beta-1 adrenergic receptor	ChEMBL	590	17	5	7	4.3	CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	CHEMBL102194	4518	None	0	Human	Functional	pIC50	=	7.6	7.6	-38	3	Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorCompound was tested for the antagonistic activity against Beta-1 adrenergic receptor	ChEMBL	590	17	5	7	4.3	CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	14739907	164228	None	0	Human	Functional	pIC50	=	6.6	6.6	1	2	Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs	ChEMBL	367	10	2	6	2.6	Cc1cccc(OCC(O)CNCCOc2ccc(-n3ccnc3)cc2)c1	10.1021/jm00172a033
	CHEMBL421005	164228	None	0	Human	Functional	pIC50	=	6.6	6.6	1	2	Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs	ChEMBL	367	10	2	6	2.6	Cc1cccc(OCC(O)CNCCOc2ccc(-n3ccnc3)cc2)c1	10.1021/jm00172a033
	14739906	210146	None	0	Human	Functional	pIC50	=	6.6	6.6	16	2	Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs	ChEMBL	411	13	2	7	2.5	COCCc1ccc(OCC(O)CNCCOc2ccc(-n3ccnc3)cc2)cc1	10.1021/jm00172a033
	CHEMBL95457	210146	None	0	Human	Functional	pIC50	=	6.6	6.6	16	2	Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs	ChEMBL	411	13	2	7	2.5	COCCc1ccc(OCC(O)CNCCOc2ccc(-n3ccnc3)cc2)cc1	10.1021/jm00172a033
	53326195	58671	None	0	Human	Functional	pIC50	=	5.5	5.5	-194	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(CC2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	CHEMBL1684577	58671	None	0	Human	Functional	pIC50	=	5.5	5.5	-194	3	Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor	ChEMBL	649	9	3	6	7.7	O=S(=O)(Nc1ccc(CC2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1	10.1016/j.bmcl.2010.12.087
	9853471	207312	None	0	Human	Functional	pIC50	=	5.5	5.5	-389	3	Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL75604	207312	None	0	Human	Functional	pIC50	=	5.5	5.5	-389	3	Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1	10.1016/s0960-894x(00)00459-5
	146015362	947	None	12	Rat	Functional	pIC50	=	4.5	4.5	-53703	5	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	421	8	4	6	2.2	C[C@H](Cc1ccc2c(c1)OC(O2)(C(=O)O)C(=O)O)NC[C@@H](c1cccc(c1)Cl)O	10.1021/jm00094a025
	3462	947	None	12	Rat	Functional	pIC50	=	4.5	4.5	-53703	5	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	421	8	4	6	2.2	C[C@H](Cc1ccc2c(c1)OC(O2)(C(=O)O)C(=O)O)NC[C@@H](c1cccc(c1)Cl)O	10.1021/jm00094a025
	5486546	947	None	12	Rat	Functional	pIC50	=	4.5	4.5	-53703	5	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	421	8	4	6	2.2	C[C@H](Cc1ccc2c(c1)OC(O2)(C(=O)O)C(=O)O)NC[C@@H](c1cccc(c1)Cl)O	10.1021/jm00094a025
	CHEMBL1204876	947	None	12	Rat	Functional	pIC50	=	4.5	4.5	-53703	5	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	421	8	4	6	2.2	C[C@H](Cc1ccc2c(c1)OC(O2)(C(=O)O)C(=O)O)NC[C@@H](c1cccc(c1)Cl)O	10.1021/jm00094a025
	1786	2520	None	51	Guinea pig	Functional	pIC50	=	6.5	6.5	-4	7	Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	4171	2520	None	51	Guinea pig	Functional	pIC50	=	6.5	6.5	-4	7	Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	4171.0	2520	None	51	Guinea pig	Functional	pIC50	=	6.5	6.5	-4	7	Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	553	2520	None	51	Guinea pig	Functional	pIC50	=	6.5	6.5	-4	7	Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	CHEMBL13	2520	None	51	Guinea pig	Functional	pIC50	=	6.5	6.5	-4	7	Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	DB00264	2520	None	51	Guinea pig	Functional	pIC50	=	6.5	6.5	-4	7	Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1016/S0960-894X(97)00207-2
	3687256	6836	None	5	Human	Functional	pIC50	=	6.4	6.4	3	2	Antagonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assayAntagonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assay	ChEMBL	500	8	1	5	5.0	Cc1ccc(C(C)C)c(OCC(O)CN2CCC(CN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1	10.1016/j.bmcl.2010.04.009
	CHEMBL1083994	6836	None	5	Human	Functional	pIC50	=	6.4	6.4	3	2	Antagonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assayAntagonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assay	ChEMBL	500	8	1	5	5.0	Cc1ccc(C(C)C)c(OCC(O)CN2CCC(CN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1	10.1016/j.bmcl.2010.04.009
	14739905	210744	None	0	Human	Functional	pIC50	=	7.4	7.4	7	2	Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs	ChEMBL	353	10	2	6	2.3	OC(CNCCOc1ccc(-n2ccnc2)cc1)COc1ccccc1	10.1021/jm00172a033
	CHEMBL98975	210744	None	0	Human	Functional	pIC50	=	7.4	7.4	7	2	Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs	ChEMBL	353	10	2	6	2.3	OC(CNCCOc1ccc(-n2ccnc2)cc1)COc1ccccc1	10.1021/jm00172a033
	1499	2091	None	34	Rat	Functional	pIC50	=	8.3	8.3	-269	38	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00094a025
	3779	2091	None	34	Rat	Functional	pIC50	=	8.3	8.3	-269	38	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00094a025
	3779.0	2091	None	34	Rat	Functional	pIC50	=	8.3	8.3	-269	38	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00094a025
	536	2091	None	34	Rat	Functional	pIC50	=	8.3	8.3	-269	38	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00094a025
	CHEMBL434	2091	None	34	Rat	Functional	pIC50	=	8.3	8.3	-269	38	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00094a025
	DB01064	2091	None	34	Rat	Functional	pIC50	=	8.3	8.3	-269	38	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm00094a025
	14823035	141650	None	1	Rat	Functional	pIC50	=	6.3	6.3	-10	4	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	377	9	2	5	3.1	COC(=O)COc1ccc(C[C@@H](C)NC[C@H](O)c2cccc(Cl)c2)cc1	10.1021/jm00094a025
	CHEMBL38486	141650	None	1	Rat	Functional	pIC50	=	6.3	6.3	-10	4	In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle	ChEMBL	377	9	2	5	3.1	COC(=O)COc1ccc(C[C@@H](C)NC[C@H](O)c2cccc(Cl)c2)cc1	10.1021/jm00094a025
	14739908	107302	None	0	Human	Functional	pIC50	=	5.3	5.3	1	2	Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs	ChEMBL	416	10	3	7	1.9	CS(=O)(=O)Nc1ccc(C(O)CNCCOc2ccc(-n3ccnc3)cc2)cc1	10.1021/jm00172a033
	CHEMBL316868	107302	None	0	Human	Functional	pIC50	=	5.3	5.3	1	2	Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs	ChEMBL	416	10	3	7	1.9	CS(=O)(=O)Nc1ccc(C(O)CNCCOc2ccc(-n3ccnc3)cc2)cc1	10.1021/jm00172a033
	44313150	103832	None	0	Human	Functional	pIC50	=	6.3	6.3	-6	3	Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)c2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL308868	103832	None	0	Human	Functional	pIC50	=	6.3	6.3	-6	3	Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)c2)cc1	10.1016/s0960-894x(00)00459-5
	65772	60423	None	5	Human	Functional	pIC50	=	8.2	8.2	-5	11	Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1016/s0960-894x(00)00459-5
	CHEMBL174984	60423	None	5	Human	Functional	pIC50	=	8.2	8.2	-5	11	Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1016/s0960-894x(00)00459-5
	10283539	167968	None	0	Human	Functional	pIC50	=	5.2	5.2	-1479	3	Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorCompound was tested for the antagonistic activity against Beta-1 adrenergic receptor	ChEMBL	697	14	6	9	2.8	CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00607-8
	CHEMBL431048	167968	None	0	Human	Functional	pIC50	=	5.2	5.2	-1479	3	Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorCompound was tested for the antagonistic activity against Beta-1 adrenergic receptor	ChEMBL	697	14	6	9	2.8	CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00607-8
	127034966	136614	None	0	Human	Functional	pIC50	=	6.2	6.2	-1	2	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	260	5	2	4	1.6	CB1C=Cc2cccc(OCC(O)CN(C)C)c2N1	10.1021/acs.jmedchem.5b01088
	CHEMBL3736433	136614	None	0	Human	Functional	pIC50	=	6.2	6.2	-1	2	Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay	ChEMBL	260	5	2	4	1.6	CB1C=Cc2cccc(OCC(O)CN(C)C)c2N1	10.1021/acs.jmedchem.5b01088
	187238	78149	None	6	Rat	Functional	pKd	=	10.2	10.2	-	0	Antagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cells	ChEMBL	413	5	3	4	2.8	CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12	10.1021/jm050624l
	CHEMBL210309	78149	None	6	Rat	Functional	pKd	=	10.2	10.2	-	0	Antagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cells	ChEMBL	413	5	3	4	2.8	CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12	10.1021/jm050624l
	187238	78149	None	6	Rat	Functional	pKd	=	10.2	10.2	-	0	Antagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cells	ChEMBL	413	5	3	4	2.8	CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12	10.1021/jm050624l
	CHEMBL210309	78149	None	6	Rat	Functional	pKd	=	10.2	10.2	-	0	Antagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cells	ChEMBL	413	5	3	4	2.8	CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12	10.1021/jm050624l
	187238	78149	None	6	Rat	Functional	pKd	=	10.2	10.2	-	0	Antagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cellsAntagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cells	ChEMBL	413	5	3	4	2.8	CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12	10.1021/jm050624l
	CHEMBL210309	78149	None	6	Rat	Functional	pKd	=	10.2	10.2	-	0	Antagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cellsAntagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cells	ChEMBL	413	5	3	4	2.8	CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12	10.1021/jm050624l
	187238	78149	None	6	Rat	Functional	pKd	=	10.1	10.1	-	0	Antagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cells	ChEMBL	413	5	3	4	2.8	CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12	10.1021/jm050624l
	CHEMBL210309	78149	None	6	Rat	Functional	pKd	=	10.1	10.1	-	0	Antagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cells	ChEMBL	413	5	3	4	2.8	CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12	10.1021/jm050624l
	13040915	102987	None	0	Guinea pig	Functional	pKd	=	10	10.0	-	0	Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3hAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h	ChEMBL	325	10	2	7	0.8	CCOC(=O)CCNCC(O)COc1ccccc1C(=O)OC	10.1021/jm00354a003
	CHEMBL30622	102987	None	0	Guinea pig	Functional	pKd	=	10	10.0	-	0	Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3hAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h	ChEMBL	325	10	2	7	0.8	CCOC(=O)CCNCC(O)COc1ccccc1C(=O)OC	10.1021/jm00354a003
	3047497	13404	None	5	Rat	Functional	pKd	=	9.6	9.6	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	321	11	2	4	2.8	CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL1192675	13404	None	5	Rat	Functional	pKd	=	9.6	9.6	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	321	11	2	4	2.8	CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL543955	13404	None	5	Rat	Functional	pKd	=	9.6	9.6	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	321	11	2	4	2.8	CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	3047497	13404	None	5	Rat	Functional	pKd	=	9.6	9.6	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	321	11	2	4	2.8	CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL1192675	13404	None	5	Rat	Functional	pKd	=	9.6	9.6	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	321	11	2	4	2.8	CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL543955	13404	None	5	Rat	Functional	pKd	=	9.6	9.6	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	321	11	2	4	2.8	CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	187238	78149	None	6	Rat	Functional	pKd	=	9.5	9.5	-	0	Antagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cells	ChEMBL	413	5	3	4	2.8	CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12	10.1021/jm050624l
	CHEMBL210309	78149	None	6	Rat	Functional	pKd	=	9.5	9.5	-	0	Antagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cells	ChEMBL	413	5	3	4	2.8	CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12	10.1021/jm050624l
	2685	890	None	19	Human	Functional	pKd	=	9.5	9.5	-	1	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	494	11	4	8	2.3	OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O	10.1021/jm400348g
	541	890	None	19	Human	Functional	pKd	=	9.5	9.5	-	1	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	494	11	4	8	2.3	OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O	10.1021/jm400348g
	CHEMBL280822	890	None	19	Human	Functional	pKd	=	9.5	9.5	-	1	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	494	11	4	8	2.3	OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O	10.1021/jm400348g
	123686	1981	None	38	Human	Functional	pKd	=	9.5	9.5	74	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	354	9	4	5	1.7	C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O	10.1021/jm400348g
	12581	1981	None	38	Human	Functional	pKd	=	9.5	9.5	74	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	354	9	4	5	1.7	C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O	10.1021/jm400348g
	CHEMBL11268	1981	None	38	Human	Functional	pKd	=	9.5	9.5	74	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	354	9	4	5	1.7	C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O	10.1021/jm400348g
	33624	3821	None	21	Guinea pig	Functional	pKd	=	9.4	9.4	-	6	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1021/jm00350a009
	33624.0	3821	None	21	Guinea pig	Functional	pKd	=	9.4	9.4	-	6	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1021/jm00350a009
	4061	3821	None	21	Guinea pig	Functional	pKd	=	9.4	9.4	-	6	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1021/jm00350a009
	565	3821	None	21	Guinea pig	Functional	pKd	=	9.4	9.4	-	6	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1021/jm00350a009
	CHEMBL499	3821	None	21	Guinea pig	Functional	pKd	=	9.4	9.4	-	6	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1021/jm00350a009
	DB00373	3821	None	21	Guinea pig	Functional	pKd	=	9.4	9.4	-	6	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1021/jm00350a009
	13187527	97144	None	0	Rat	Functional	pKd	=	9.3	9.3	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	321	10	2	4	2.9	CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1	10.1021/jm00389a008
	CHEMBL267375	97144	None	0	Rat	Functional	pKd	=	9.3	9.3	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	321	10	2	4	2.9	CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1	10.1021/jm00389a008
	CHEMBL542536	97144	None	0	Rat	Functional	pKd	=	9.3	9.3	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	321	10	2	4	2.9	CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1	10.1021/jm00389a008
	56598832	88302	None	0	Human	Functional	pKd	=	9	9.0	4365	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	527	16	5	7	3.3	O=C(NCCNCC(O)COc1ccc(OCCOCCc2ccc(F)cc2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	CHEMBL2348218	88302	None	0	Human	Functional	pKd	=	9	9.0	4365	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	527	16	5	7	3.3	O=C(NCCNCC(O)COc1ccc(OCCOCCc2ccc(F)cc2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	2685	890	None	19	Human	Functional	pKd	=	9.0	9.0	-	1	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	494	11	4	8	2.3	OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O	10.1016/j.ejmech.2022.114961
	541	890	None	19	Human	Functional	pKd	=	9.0	9.0	-	1	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	494	11	4	8	2.3	OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O	10.1016/j.ejmech.2022.114961
	CHEMBL280822	890	None	19	Human	Functional	pKd	=	9.0	9.0	-	1	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	494	11	4	8	2.3	OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O	10.1016/j.ejmech.2022.114961
	66653268	88285	None	0	Human	Functional	pKd	=	8.8	8.8	3311	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	491	14	4	6	3.8	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1cccc(Cl)c1	10.1021/jm400348g
	CHEMBL2348201	88285	None	0	Human	Functional	pKd	=	8.8	8.8	3311	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	491	14	4	6	3.8	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1cccc(Cl)c1	10.1021/jm400348g
	5311116	2334	None	9	Human	Functional	pKd	=	8.8	8.8	4365	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	484	15	5	8	2.2	N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O	10.1021/jm400348g
	544	2334	None	9	Human	Functional	pKd	=	8.8	8.8	4365	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	484	15	5	8	2.2	N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O	10.1021/jm400348g
	CHEMBL207802	2334	None	9	Human	Functional	pKd	=	8.8	8.8	4365	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	484	15	5	8	2.2	N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O	10.1021/jm400348g
	2303	3187	None	44	Human	Functional	pKd	=	8.7	8.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	4946	3187	None	44	Human	Functional	pKd	=	8.7	8.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	564	3187	None	44	Human	Functional	pKd	=	8.7	8.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	63	3187	None	44	Human	Functional	pKd	=	8.7	8.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	91536	3187	None	44	Human	Functional	pKd	=	8.7	8.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	CHEMBL27	3187	None	44	Human	Functional	pKd	=	8.7	8.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	CHEMBL452861	3187	None	44	Human	Functional	pKd	=	8.7	8.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	DB00571	3187	None	44	Human	Functional	pKd	=	8.7	8.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	12733305	60407	None	0	Guinea pig	Functional	pKd	=	8.7	8.7	-	0	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	357	8	2	6	2.5	COc1ccc(CCNCC(O)C2=COc3ccccc3O2)cc1OC	10.1021/jm00140a015
	CHEMBL174853	60407	None	0	Guinea pig	Functional	pKd	=	8.7	8.7	-	0	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	357	8	2	6	2.5	COc1ccc(CCNCC(O)C2=COc3ccccc3O2)cc1OC	10.1021/jm00140a015
	13187527	97144	None	0	Rat	Functional	pKd	=	8.7	8.7	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	321	10	2	4	2.9	CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1	10.1021/jm00389a008
	CHEMBL267375	97144	None	0	Rat	Functional	pKd	=	8.7	8.7	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	321	10	2	4	2.9	CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1	10.1021/jm00389a008
	CHEMBL542536	97144	None	0	Rat	Functional	pKd	=	8.7	8.7	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	321	10	2	4	2.9	CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1	10.1021/jm00389a008
	44288749	164365	None	0	Rat	Functional	pKd	=	8.0	8.0	-	0	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	330	8	2	4	4.0	CC(C)(C)c1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1	10.1021/jm970338c
	CHEMBL42117	164365	None	0	Rat	Functional	pKd	=	8.0	8.0	-	0	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	330	8	2	4	4.0	CC(C)(C)c1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1	10.1021/jm970338c
	44288749	164365	None	0	Rat	Functional	pKd	=	8.0	8.0	-	0	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	330	8	2	4	4.0	CC(C)(C)c1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1	10.1021/jm970338c
	CHEMBL42117	164365	None	0	Rat	Functional	pKd	=	8.0	8.0	-	0	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	330	8	2	4	4.0	CC(C)(C)c1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1	10.1021/jm970338c
	11722868	104434	None	0	Guinea pig	Functional	pKd	=	7	7.0	-	0	Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 minAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 min	ChEMBL	309	8	2	5	1.9	COC(=O)CCc1ccc(OCC(O)CNC(C)(C)C)cc1	10.1021/jm00354a003
	CHEMBL31025	104434	None	0	Guinea pig	Functional	pKd	=	7	7.0	-	0	Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 minAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 min	ChEMBL	309	8	2	5	1.9	COC(=O)CCc1ccc(OCC(O)CNC(C)(C)C)cc1	10.1021/jm00354a003
	13040919	106123	None	0	Guinea pig	Functional	pKd	=	5	5.0	-	0	Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3hAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h	ChEMBL	339	9	2	7	1.1	CCOC(=O)C(C)(C)NCC(O)COc1ccccc1C(=O)OC	10.1021/jm00354a003
	CHEMBL31335	106123	None	0	Guinea pig	Functional	pKd	=	5	5.0	-	0	Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3hAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h	ChEMBL	339	9	2	7	1.1	CCOC(=O)C(C)(C)NCC(O)COc1ccccc1C(=O)OC	10.1021/jm00354a003
	172461665	196598	None	0	Human	Functional	pKd	=	7.0	7.0	134	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	366	7	2	6	2.4	O[C@@H](CNCC1COc2ccccc2O1)COc1cccc2cnccc12	10.1016/j.ejmech.2022.114961
	CHEMBL5427527	196598	None	0	Human	Functional	pKd	=	7.0	7.0	134	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	366	7	2	6	2.4	O[C@@H](CNCC1COc2ccccc2O1)COc1cccc2cnccc12	10.1016/j.ejmech.2022.114961
	44371562	49732	None	0	Guinea pig	Functional	pKd	=	5.0	5.0	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	257	7	2	5	1.2	CC(C)NCC(O)COC(=O)Cc1cccs1	10.1021/jm00387a006
	CHEMBL156683	49732	None	0	Guinea pig	Functional	pKd	=	5.0	5.0	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	257	7	2	5	1.2	CC(C)NCC(O)COC(=O)Cc1cccs1	10.1021/jm00387a006
	20554487	13304	None	0	Rat	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	369	11	2	5	2.2	CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL1191855	13304	None	0	Rat	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	369	11	2	5	2.2	CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL543011	13304	None	0	Rat	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	369	11	2	5	2.2	CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCC2)cc1	10.1021/jm00389a008
	54757126	65514	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	893	26	4	10	6.8	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	CHEMBL1830492	65514	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	893	26	4	10	6.8	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	14856222	172752	None	0	Guinea pig	Functional	pKd	=	4.9	4.9	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	217	5	2	4	0.9	CC(C)C(=O)OCC(O)CNC(C)(C)C	10.1021/jm00387a006
	CHEMBL449651	172752	None	0	Guinea pig	Functional	pKd	=	4.9	4.9	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	217	5	2	4	0.9	CC(C)C(=O)OCC(O)CNC(C)(C)C	10.1021/jm00387a006
	12733304	128304	None	0	Guinea pig	Functional	pKd	=	5.9	5.9	-	0	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	275	3	1	4	2.5	OC(CN1CCCCCC1)C1=COc2ccccc2O1	10.1021/jm00140a015
	CHEMBL366558	128304	None	0	Guinea pig	Functional	pKd	=	5.9	5.9	-	0	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	275	3	1	4	2.5	OC(CN1CCCCCC1)C1=COc2ccccc2O1	10.1021/jm00140a015
	44288217	155243	None	0	Rat	Functional	pKd	=	7.9	7.9	-	0	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	288	8	2	4	3.0	Cc1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1	10.1021/jm970338c
	CHEMBL40217	155243	None	0	Rat	Functional	pKd	=	7.9	7.9	-	0	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	288	8	2	4	3.0	Cc1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1	10.1021/jm970338c
	2303	3187	None	44	Guinea pig	Functional	pKd	=	7.9	7.9	-21	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	4946	3187	None	44	Guinea pig	Functional	pKd	=	7.9	7.9	-21	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	564	3187	None	44	Guinea pig	Functional	pKd	=	7.9	7.9	-21	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	63	3187	None	44	Guinea pig	Functional	pKd	=	7.9	7.9	-21	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	91536	3187	None	44	Guinea pig	Functional	pKd	=	7.9	7.9	-21	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	CHEMBL27	3187	None	44	Guinea pig	Functional	pKd	=	7.9	7.9	-21	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	CHEMBL452861	3187	None	44	Guinea pig	Functional	pKd	=	7.9	7.9	-21	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	DB00571	3187	None	44	Guinea pig	Functional	pKd	=	7.9	7.9	-21	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	44371486	14251	None	0	Guinea pig	Functional	pKd	=	6.9	6.9	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	230	7	2	4	1.9	CCC/C(C)=N\OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL1161387	14251	None	0	Guinea pig	Functional	pKd	=	6.9	6.9	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	230	7	2	4	1.9	CCC/C(C)=N\OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL1199437	14251	None	0	Guinea pig	Functional	pKd	=	6.9	6.9	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	230	7	2	4	1.9	CCC/C(C)=N\OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	54757229	65536	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	795	22	4	8	6.3	C=CCc1ccccc1OCC(O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1	10.1021/jm2008562
	CHEMBL1830617	65536	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	795	22	4	8	6.3	C=CCc1ccccc1OCC(O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1	10.1021/jm2008562
	3682	189546	None	13	Human	Functional	pKd	=	6.9	6.9	-	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	277	6	2	3	2.6	Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2	10.1016/j.ejmech.2022.114961
	CHEMBL1256784	189546	None	13	Human	Functional	pKd	=	6.9	6.9	-	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	277	6	2	3	2.6	Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2	10.1016/j.ejmech.2022.114961
	CHEMBL513389	189546	None	13	Human	Functional	pKd	=	6.9	6.9	-	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	277	6	2	3	2.6	Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2	10.1016/j.ejmech.2022.114961
	44371537	50684	None	0	Guinea pig	Functional	pKd	=	4.9	4.9	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	243	6	2	4	1.5	CC(C)NCC(O)COC(=O)C1CCCCC1	10.1021/jm00387a006
	CHEMBL157557	50684	None	0	Guinea pig	Functional	pKd	=	4.9	4.9	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	243	6	2	4	1.5	CC(C)NCC(O)COC(=O)C1CCCCC1	10.1021/jm00387a006
	12348305	97049	None	0	Guinea pig	Functional	pKd	=	6.9	6.9	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	281	6	2	6	0.9	CC(C)NCC(O)COC(=O)c1ccc2c(c1)OCO2	10.1021/jm00387a006
	CHEMBL266548	97049	None	0	Guinea pig	Functional	pKd	=	6.9	6.9	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	281	6	2	6	0.9	CC(C)NCC(O)COC(=O)c1ccc2c(c1)OCO2	10.1021/jm00387a006
	2369	622	None	46	Rat	Functional	pKd	=	6.9	6.9	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	2369.0	622	None	46	Rat	Functional	pKd	=	6.9	6.9	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	356	622	None	46	Rat	Functional	pKd	=	6.9	6.9	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	549	622	None	46	Rat	Functional	pKd	=	6.9	6.9	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	CHEMBL423	622	None	46	Rat	Functional	pKd	=	6.9	6.9	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	DB00195	622	None	46	Rat	Functional	pKd	=	6.9	6.9	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	12606708	13085	None	0	Guinea pig	Functional	pKd	=	5.9	5.9	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	282	6	2	4	2.6	CC(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C	10.1021/jm00180a007
	CHEMBL1190195	13085	None	0	Guinea pig	Functional	pKd	=	5.9	5.9	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	282	6	2	4	2.6	CC(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C	10.1021/jm00180a007
	CHEMBL540337	13085	None	0	Guinea pig	Functional	pKd	=	5.9	5.9	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	282	6	2	4	2.6	CC(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C	10.1021/jm00180a007
	44287476	12016	None	0	Guinea pig	Functional	pKd	=	5.9	5.9	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	230	7	2	4	1.9	CCC(CC)=NOCC(O)CNC(C)(C)C	10.1021/jm00380a001
	CHEMBL1183311	12016	None	0	Guinea pig	Functional	pKd	=	5.9	5.9	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	230	7	2	4	1.9	CCC(CC)=NOCC(O)CNC(C)(C)C	10.1021/jm00380a001
	CHEMBL289858	12016	None	0	Guinea pig	Functional	pKd	=	5.9	5.9	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	230	7	2	4	1.9	CCC(CC)=NOCC(O)CNC(C)(C)C	10.1021/jm00380a001
	3047527	206080	None	0	Rat	Functional	pKd	=	6.9	6.9	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	335	11	2	4	3.2	CC(C)NCC(O)COc1ccc(CCOCC2CCCC2)cc1	10.1021/jm00389a008
	CHEMBL6712	206080	None	0	Rat	Functional	pKd	=	6.9	6.9	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	335	11	2	4	3.2	CC(C)NCC(O)COc1ccc(CCOCC2CCCC2)cc1	10.1021/jm00389a008
	2447486	63080	None	0	Guinea pig	Functional	pKd	=	7.9	7.9	-	2	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	324	5	2	4	3.2	CC(C)(C)NC[C@@H](O)CON=C1c2ccccc2-c2ccccc21	10.1021/jm00350a009
	CHEMBL1788270	63080	None	0	Guinea pig	Functional	pKd	=	7.9	7.9	-	2	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	324	5	2	4	3.2	CC(C)(C)NC[C@@H](O)CON=C1c2ccccc2-c2ccccc21	10.1021/jm00350a009
	54756927	65508	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	833	22	4	8	7.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNC[C@H](O)COc1cccc2ccccc12	10.1021/jm2008562
	CHEMBL1830486	65508	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	833	22	4	8	7.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNC[C@H](O)COc1cccc2ccccc12	10.1021/jm2008562
	44288217	155243	None	0	Rat	Functional	pKd	=	7.9	7.9	-	0	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	288	8	2	4	3.0	Cc1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1	10.1021/jm970338c
	CHEMBL40217	155243	None	0	Rat	Functional	pKd	=	7.9	7.9	-	0	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	288	8	2	4	3.0	Cc1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1	10.1021/jm970338c
	172446785	195127	None	0	Human	Functional	pKd	=	6.9	6.9	-2	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	389	11	2	3	4.8	CCc1ccccc1OC[C@@H](O)CNCCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2022.114961
	CHEMBL5397120	195127	None	0	Human	Functional	pKd	=	6.9	6.9	-2	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	389	11	2	3	4.8	CCc1ccccc1OC[C@@H](O)CNCCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2022.114961
	12606686	92912	None	0	Guinea pig	Functional	pKd	=	4.9	4.9	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	189	5	2	3	1.2	CC(C)OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL1161385	92912	None	0	Guinea pig	Functional	pKd	=	4.9	4.9	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	189	5	2	3	1.2	CC(C)OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL24391	92912	None	0	Guinea pig	Functional	pKd	=	4.9	4.9	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	189	5	2	3	1.2	CC(C)OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	1786	2520	None	51	Guinea pig	Functional	pKd	=	7.8	7.8	-4	7	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00350a009
	4171	2520	None	51	Guinea pig	Functional	pKd	=	7.8	7.8	-4	7	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00350a009
	4171.0	2520	None	51	Guinea pig	Functional	pKd	=	7.8	7.8	-4	7	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00350a009
	553	2520	None	51	Guinea pig	Functional	pKd	=	7.8	7.8	-4	7	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00350a009
	CHEMBL13	2520	None	51	Guinea pig	Functional	pKd	=	7.8	7.8	-4	7	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00350a009
	DB00264	2520	None	51	Guinea pig	Functional	pKd	=	7.8	7.8	-4	7	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00350a009
	12733308	122617	None	0	Guinea pig	Functional	pKd	=	6.8	6.8	-	0	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	393	4	2	7	3.1	Oc1nc2ccccc2n1C1CCN(CC(O)C2=COc3ccccc3O2)CC1	10.1021/jm00140a015
	CHEMBL360139	122617	None	0	Guinea pig	Functional	pKd	=	6.8	6.8	-	0	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	393	4	2	7	3.1	Oc1nc2ccccc2n1C1CCN(CC(O)C2=COc3ccccc3O2)CC1	10.1021/jm00140a015
	3047500	13282	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	349	11	2	4	3.6	CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1	10.1021/jm00389a008
	CHEMBL1191645	13282	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	349	11	2	4	3.6	CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1	10.1021/jm00389a008
	CHEMBL542776	13282	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	349	11	2	4	3.6	CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1	10.1021/jm00389a008
	3047500	13282	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	349	11	2	4	3.6	CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1	10.1021/jm00389a008
	CHEMBL1191645	13282	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	349	11	2	4	3.6	CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1	10.1021/jm00389a008
	CHEMBL542776	13282	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	349	11	2	4	3.6	CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1	10.1021/jm00389a008
	44287622	12005	None	0	Guinea pig	Functional	pKd	=	4.8	4.8	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	258	7	2	4	2.4	CC(C)C(=NOCC(O)CNC(C)(C)C)C(C)C	10.1021/jm00380a001
	CHEMBL1183276	12005	None	0	Guinea pig	Functional	pKd	=	4.8	4.8	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	258	7	2	4	2.4	CC(C)C(=NOCC(O)CNC(C)(C)C)C(C)C	10.1021/jm00380a001
	CHEMBL288140	12005	None	0	Guinea pig	Functional	pKd	=	4.8	4.8	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	258	7	2	4	2.4	CC(C)C(=NOCC(O)CNC(C)(C)C)C(C)C	10.1021/jm00380a001
	10403687	2511	None	2	Guinea pig	Functional	pKd	=	4.8	4.8	-	2	Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1205	2511	None	2	Guinea pig	Functional	pKd	=	4.8	4.8	-	2	Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275035	2511	None	2	Guinea pig	Functional	pKd	=	4.8	4.8	-	2	Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	12733301	60430	None	0	Guinea pig	Functional	pKd	=	7.8	7.8	-	0	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	235	4	2	4	1.7	CC(C)NCC(O)C1=COc2ccccc2O1	10.1021/jm00140a015
	CHEMBL175010	60430	None	0	Guinea pig	Functional	pKd	=	7.8	7.8	-	0	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	235	4	2	4	1.7	CC(C)NCC(O)C1=COc2ccccc2O1	10.1021/jm00140a015
	44371406	11668	None	0	Guinea pig	Functional	pKd	=	6.8	6.8	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	278	9	2	4	2.4	C/C(CCc1ccccc1)=N/OCC(O)CNC(C)C	10.1021/jm00180a007
	CHEMBL1181107	11668	None	0	Guinea pig	Functional	pKd	=	6.8	6.8	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	278	9	2	4	2.4	C/C(CCc1ccccc1)=N/OCC(O)CNC(C)C	10.1021/jm00180a007
	CHEMBL155714	11668	None	0	Guinea pig	Functional	pKd	=	6.8	6.8	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	278	9	2	4	2.4	C/C(CCc1ccccc1)=N/OCC(O)CNC(C)C	10.1021/jm00180a007
	44264144	13283	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	385	11	2	6	1.6	CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCCO2)cc1	10.1021/jm00389a008
	CHEMBL1191646	13283	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	385	11	2	6	1.6	CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCCO2)cc1	10.1021/jm00389a008
	CHEMBL542777	13283	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	385	11	2	6	1.6	CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCCO2)cc1	10.1021/jm00389a008
	361497	49094	None	0	Guinea pig	Functional	pKd	=	5.8	5.8	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	243	6	2	5	1.3	CC(C)NCC(O)COC(=O)c1cccs1	10.1021/jm00387a006
	CHEMBL156147	49094	None	0	Guinea pig	Functional	pKd	=	5.8	5.8	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	243	6	2	5	1.3	CC(C)NCC(O)COC(=O)c1cccs1	10.1021/jm00387a006
	172454272	196013	None	0	Human	Functional	pKd	=	5.8	5.8	-	1	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	359	7	2	7	1.6	O[C@@H](CNCC1COc2ccccc2O1)COc1ccc2c(c1)OCO2	10.1016/j.ejmech.2022.114961
	CHEMBL5415148	196013	None	0	Human	Functional	pKd	=	5.8	5.8	-	1	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	359	7	2	7	1.6	O[C@@H](CNCC1COc2ccccc2O1)COc1ccc2c(c1)OCO2	10.1016/j.ejmech.2022.114961
	12778441	78397	None	0	Guinea pig	Functional	pKd	=	7.8	7.8	-	0	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	338	7	2	4	3.6	CCC(C)(C)NC[C@H](O)CON=C1c2ccccc2-c2ccccc21	10.1021/jm00350a009
	CHEMBL2110257	78397	None	0	Guinea pig	Functional	pKd	=	7.8	7.8	-	0	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	338	7	2	4	3.6	CCC(C)(C)NC[C@H](O)CON=C1c2ccccc2-c2ccccc21	10.1021/jm00350a009
	3486	3157	None	44	Guinea pig	Functional	pKd	=	5.8	5.8	-	2	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00387a006
	4883	3157	None	44	Guinea pig	Functional	pKd	=	5.8	5.8	-	2	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00387a006
	555	3157	None	44	Guinea pig	Functional	pKd	=	5.8	5.8	-	2	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00387a006
	CHEMBL6995	3157	None	44	Guinea pig	Functional	pKd	=	5.8	5.8	-	2	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00387a006
	DB01297	3157	None	44	Guinea pig	Functional	pKd	=	5.8	5.8	-	2	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00387a006
	172468087	196633	None	0	Human	Functional	pKd	=	5.8	5.8	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	459	10	2	5	5.0	CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1	10.1016/j.ejmech.2022.114961
	CHEMBL5428413	196633	None	0	Human	Functional	pKd	=	5.8	5.8	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	459	10	2	5	5.0	CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1	10.1016/j.ejmech.2022.114961
	3486	3157	None	44	Guinea pig	Functional	pKd	=	5.8	5.8	-	2	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00380a001
	4883	3157	None	44	Guinea pig	Functional	pKd	=	5.8	5.8	-	2	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00380a001
	555	3157	None	44	Guinea pig	Functional	pKd	=	5.8	5.8	-	2	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00380a001
	CHEMBL6995	3157	None	44	Guinea pig	Functional	pKd	=	5.8	5.8	-	2	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00380a001
	DB01297	3157	None	44	Guinea pig	Functional	pKd	=	5.8	5.8	-	2	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00380a001
	12606710	13401	None	0	Guinea pig	Functional	pKd	=	4.8	4.8	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	204	6	3	4	0.7	CC(C)NOCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL1192661	13401	None	0	Guinea pig	Functional	pKd	=	4.8	4.8	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	204	6	3	4	0.7	CC(C)NOCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL543940	13401	None	0	Guinea pig	Functional	pKd	=	4.8	4.8	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	204	6	3	4	0.7	CC(C)NOCC(O)CNC(C)(C)C	10.1021/jm00180a007
	44287431	11232	None	0	Guinea pig	Functional	pKd	=	4.8	4.8	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	244	8	2	4	2.0	CC(C)NCC(O)CON=C(C(C)C)C(C)C	10.1021/jm00380a001
	CHEMBL1178793	11232	None	0	Guinea pig	Functional	pKd	=	4.8	4.8	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	244	8	2	4	2.0	CC(C)NCC(O)CON=C(C(C)C)C(C)C	10.1021/jm00380a001
	CHEMBL41839	11232	None	0	Guinea pig	Functional	pKd	=	4.8	4.8	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	244	8	2	4	2.0	CC(C)NCC(O)CON=C(C(C)C)C(C)C	10.1021/jm00380a001
	54757331	65538	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	883	28	4	10	6.3	C=CCc1ccccc1OCC(O)CNCCOCCOCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1	10.1021/jm2008562
	CHEMBL1830619	65538	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	883	28	4	10	6.3	C=CCc1ccccc1OCC(O)CNCCOCCOCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1	10.1021/jm2008562
	155774	4096	None	34	Human	Functional	pKd	=	7.8	7.8	38	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	2848	4096	None	34	Human	Functional	pKd	=	7.8	7.8	38	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	538	4096	None	34	Human	Functional	pKd	=	7.8	7.8	38	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	CHEMBL75753	4096	None	34	Human	Functional	pKd	=	7.8	7.8	38	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	DB13781	4096	None	34	Human	Functional	pKd	=	7.8	7.8	38	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	56598831	89177	None	0	Human	Functional	pKd	=	7.8	7.8	1023	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	459	15	5	7	2.3	O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	CHEMBL2348220	89177	None	0	Human	Functional	pKd	=	7.8	7.8	1023	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	459	15	5	7	2.3	O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	CHEMBL2365796	89177	None	0	Human	Functional	pKd	=	7.8	7.8	1023	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	459	15	5	7	2.3	O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	44264411	13405	None	0	Rat	Functional	pKd	=	7.8	7.8	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	443	15	2	6	3.6	COc1ccc(CCNCC(O)COc2ccc(CCOCC3CCC3)cc2)cc1OC	10.1021/jm00389a008
	CHEMBL1192677	13405	None	0	Rat	Functional	pKd	=	7.8	7.8	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	443	15	2	6	3.6	COc1ccc(CCNCC(O)COc2ccc(CCOCC3CCC3)cc2)cc1OC	10.1021/jm00389a008
	CHEMBL543957	13405	None	0	Rat	Functional	pKd	=	7.8	7.8	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	443	15	2	6	3.6	COc1ccc(CCNCC(O)COc2ccc(CCOCC3CCC3)cc2)cc1OC	10.1021/jm00389a008
	3486	3157	None	44	Guinea pig	Functional	pKd	=	6.8	6.8	-	2	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00140a015
	4883	3157	None	44	Guinea pig	Functional	pKd	=	6.8	6.8	-	2	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00140a015
	555	3157	None	44	Guinea pig	Functional	pKd	=	6.8	6.8	-	2	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00140a015
	CHEMBL6995	3157	None	44	Guinea pig	Functional	pKd	=	6.8	6.8	-	2	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00140a015
	DB01297	3157	None	44	Guinea pig	Functional	pKd	=	6.8	6.8	-	2	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1021/jm00140a015
	172450718	196107	None	0	Human	Functional	pKd	=	5.8	5.8	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	426	9	3	6	3.0	CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc3c(c2)OC(C)(C)CC3=O)cc1	10.1016/j.ejmech.2022.114961
	CHEMBL5416996	196107	None	0	Human	Functional	pKd	=	5.8	5.8	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	426	9	3	6	3.0	CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc3c(c2)OC(C)(C)CC3=O)cc1	10.1016/j.ejmech.2022.114961
	137	370	None	37	Human	Functional	pKd	=	6.8	6.8	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	2119	370	None	37	Human	Functional	pKd	=	6.8	6.8	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	563	370	None	37	Human	Functional	pKd	=	6.8	6.8	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	66368	370	None	37	Human	Functional	pKd	=	6.8	6.8	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	CHEMBL266195	370	None	37	Human	Functional	pKd	=	6.8	6.8	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	DB00866	370	None	37	Human	Functional	pKd	=	6.8	6.8	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	54756927	65508	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	833	22	4	8	7.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNC[C@H](O)COc1cccc2ccccc12	10.1021/jm2008562
	CHEMBL1830486	65508	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	833	22	4	8	7.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNC[C@H](O)COc1cccc2ccccc12	10.1021/jm2008562
	12606701	11231	None	0	Guinea pig	Functional	pKd	=	5.7	5.7	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	228	6	2	4	1.7	CC(C)NCC(O)CON=C1CCCCC1	10.1021/jm00180a007
	CHEMBL1178787	11231	None	0	Guinea pig	Functional	pKd	=	5.7	5.7	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	228	6	2	4	1.7	CC(C)NCC(O)CON=C1CCCCC1	10.1021/jm00180a007
	CHEMBL41378	11231	None	0	Guinea pig	Functional	pKd	=	5.7	5.7	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	228	6	2	4	1.7	CC(C)NCC(O)CON=C1CCCCC1	10.1021/jm00180a007
	44371426	14312	None	0	Guinea pig	Functional	pKd	=	6.7	6.7	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	216	6	2	4	1.5	CC/C(C)=N\OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL1161384	14312	None	0	Guinea pig	Functional	pKd	=	6.7	6.7	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	216	6	2	4	1.5	CC/C(C)=N\OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL1199902	14312	None	0	Guinea pig	Functional	pKd	=	6.7	6.7	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	216	6	2	4	1.5	CC/C(C)=N\OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	2303	3187	None	44	Human	Functional	pKd	=	6.7	6.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	4946	3187	None	44	Human	Functional	pKd	=	6.7	6.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	564	3187	None	44	Human	Functional	pKd	=	6.7	6.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	63	3187	None	44	Human	Functional	pKd	=	6.7	6.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	91536	3187	None	44	Human	Functional	pKd	=	6.7	6.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	CHEMBL27	3187	None	44	Human	Functional	pKd	=	6.7	6.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	CHEMBL452861	3187	None	44	Human	Functional	pKd	=	6.7	6.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	DB00571	3187	None	44	Human	Functional	pKd	=	6.7	6.7	-6	20	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm2008562
	11768868	13166	None	1	Guinea pig	Functional	pKd	=	4.7	4.7	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	161	4	2	3	0.4	COCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL1190805	13166	None	1	Guinea pig	Functional	pKd	=	4.7	4.7	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	161	4	2	3	0.4	COCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL541607	13166	None	1	Guinea pig	Functional	pKd	=	4.7	4.7	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	161	4	2	3	0.4	COCC(O)CNC(C)(C)C	10.1021/jm00180a007
	12606701	11231	None	0	Guinea pig	Functional	pKd	=	4.7	4.7	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	228	6	2	4	1.7	CC(C)NCC(O)CON=C1CCCCC1	10.1021/jm00380a001
	CHEMBL1178787	11231	None	0	Guinea pig	Functional	pKd	=	4.7	4.7	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	228	6	2	4	1.7	CC(C)NCC(O)CON=C1CCCCC1	10.1021/jm00380a001
	CHEMBL41378	11231	None	0	Guinea pig	Functional	pKd	=	4.7	4.7	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	228	6	2	4	1.7	CC(C)NCC(O)CON=C1CCCCC1	10.1021/jm00380a001
	2303	3187	None	44	Guinea pig	Functional	pKd	=	8.6	8.6	-21	20	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00180a007
	4946	3187	None	44	Guinea pig	Functional	pKd	=	8.6	8.6	-21	20	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00180a007
	564	3187	None	44	Guinea pig	Functional	pKd	=	8.6	8.6	-21	20	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00180a007
	63	3187	None	44	Guinea pig	Functional	pKd	=	8.6	8.6	-21	20	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00180a007
	91536	3187	None	44	Guinea pig	Functional	pKd	=	8.6	8.6	-21	20	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00180a007
	CHEMBL27	3187	None	44	Guinea pig	Functional	pKd	=	8.6	8.6	-21	20	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00180a007
	CHEMBL452861	3187	None	44	Guinea pig	Functional	pKd	=	8.6	8.6	-21	20	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00180a007
	DB00571	3187	None	44	Guinea pig	Functional	pKd	=	8.6	8.6	-21	20	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00180a007
	2176	3127	None	40	Human	Functional	pKd	=	8.6	8.6	1	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1021/jm2008562
	4828	3127	None	40	Human	Functional	pKd	=	8.6	8.6	1	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1021/jm2008562
	4828.0	3127	None	40	Human	Functional	pKd	=	8.6	8.6	1	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1021/jm2008562
	91	3127	None	40	Human	Functional	pKd	=	8.6	8.6	1	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1021/jm2008562
	CHEMBL500	3127	None	40	Human	Functional	pKd	=	8.6	8.6	1	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1021/jm2008562
	DB00960	3127	None	40	Human	Functional	pKd	=	8.6	8.6	1	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1021/jm2008562
	2303	3187	None	44	Rat	Functional	pKd	=	8.6	8.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	4946	3187	None	44	Rat	Functional	pKd	=	8.6	8.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	564	3187	None	44	Rat	Functional	pKd	=	8.6	8.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	63	3187	None	44	Rat	Functional	pKd	=	8.6	8.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	91536	3187	None	44	Rat	Functional	pKd	=	8.6	8.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	CHEMBL27	3187	None	44	Rat	Functional	pKd	=	8.6	8.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	CHEMBL452861	3187	None	44	Rat	Functional	pKd	=	8.6	8.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	DB00571	3187	None	44	Rat	Functional	pKd	=	8.6	8.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	56597179	88303	None	0	Human	Functional	pKd	=	8.6	8.6	2754	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	473	14	5	7	2.9	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	CHEMBL2348219	88303	None	0	Human	Functional	pKd	=	8.6	8.6	2754	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	473	14	5	7	2.9	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccc(O)cc1	10.1021/jm400348g
	2369	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	2369.0	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	356	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	549	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	CHEMBL423	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	DB00195	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	44264404	13429	None	0	Rat	Functional	pKd	=	8.5	8.5	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	319	11	2	4	2.5	OC(CNC1CC1)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL1192875	13429	None	0	Rat	Functional	pKd	=	8.5	8.5	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	319	11	2	4	2.5	OC(CNC1CC1)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL544190	13429	None	0	Rat	Functional	pKd	=	8.5	8.5	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	319	11	2	4	2.5	OC(CNC1CC1)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	2369	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	2369.0	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	356	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	549	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	CHEMBL423	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	DB00195	622	None	46	Rat	Functional	pKd	=	8.5	8.5	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	44287522	11228	None	0	Guinea pig	Functional	pKd	=	4.7	4.7	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	244	10	2	4	2.3	CCCC(CCC)=NOCC(O)CNC(C)C	10.1021/jm00380a001
	CHEMBL1178778	11228	None	0	Guinea pig	Functional	pKd	=	4.7	4.7	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	244	10	2	4	2.3	CCCC(CCC)=NOCC(O)CNC(C)C	10.1021/jm00380a001
	CHEMBL40783	11228	None	0	Guinea pig	Functional	pKd	=	4.7	4.7	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	244	10	2	4	2.3	CCCC(CCC)=NOCC(O)CNC(C)C	10.1021/jm00380a001
	54757027	65512	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	889	26	4	8	9.1	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCCCCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	CHEMBL1830490	65512	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	889	26	4	8	9.1	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCCCCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	1786	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	4171	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	4171.0	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	553	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	CHEMBL13	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	DB00264	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	1786	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	4171	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	4171.0	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	553	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	CHEMBL13	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	DB00264	2520	None	51	Rat	Functional	pKd	=	7.6	7.6	-	7	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1021/jm00389a008
	172462381	196770	None	0	Human	Functional	pKd	=	5.6	5.6	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	383	9	2	5	3.4	CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCCc3ccccc3)cc2O1	10.1016/j.ejmech.2022.114961
	CHEMBL5431834	196770	None	0	Human	Functional	pKd	=	5.6	5.6	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	383	9	2	5	3.4	CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCCc3ccccc3)cc2O1	10.1016/j.ejmech.2022.114961
	54757026	65511	None	0	Human	Functional	pKd	=	6.6	6.6	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	833	22	4	8	7.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	CHEMBL1830489	65511	None	0	Human	Functional	pKd	=	6.6	6.6	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	833	22	4	8	7.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	172455562	196362	None	0	Human	Functional	pKd	=	5.6	5.6	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	383	7	2	7	2.0	O=c1ccc2ccc(OC[C@@H](O)CNCC3COc4ccccc4O3)cc2o1	10.1016/j.ejmech.2022.114961
	CHEMBL5422259	196362	None	0	Human	Functional	pKd	=	5.6	5.6	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	383	7	2	7	2.0	O=c1ccc2ccc(OC[C@@H](O)CNCC3COc4ccccc4O3)cc2o1	10.1016/j.ejmech.2022.114961
	44287498	12407	None	0	Guinea pig	Functional	pKd	=	4.6	4.6	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	214	6	2	4	1.3	CC(C)NCC(O)CON=C1CCCC1	10.1021/jm00380a001
	CHEMBL1185760	12407	None	0	Guinea pig	Functional	pKd	=	4.6	4.6	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	214	6	2	4	1.3	CC(C)NCC(O)CON=C1CCCC1	10.1021/jm00380a001
	CHEMBL431713	12407	None	0	Guinea pig	Functional	pKd	=	4.6	4.6	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	214	6	2	4	1.3	CC(C)NCC(O)CON=C1CCCC1	10.1021/jm00380a001
	127940	207342	None	5	Human	Functional	pKd	=	6.6	6.6	-	0	The compound was evaluated for the antagonistic activity against alpha-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against alpha-1 adrenergic receptor.	ChEMBL	351	8	4	3	2.9	CC(CCc1ccccc1)NCC(O)c1cc(C(N)=O)c2[nH]ccc2c1	10.1021/jm00156a019
	CHEMBL7585	207342	None	5	Human	Functional	pKd	=	6.6	6.6	-	0	The compound was evaluated for the antagonistic activity against alpha-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against alpha-1 adrenergic receptor.	ChEMBL	351	8	4	3	2.9	CC(CCc1ccccc1)NCC(O)c1cc(C(N)=O)c2[nH]ccc2c1	10.1021/jm00156a019
	172462257	196705	None	0	Human	Functional	pKd	=	6.6	6.6	-2	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	459	10	2	5	5.0	CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1	10.1016/j.ejmech.2022.114961
	CHEMBL5430355	196705	None	0	Human	Functional	pKd	=	6.6	6.6	-2	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	459	10	2	5	5.0	CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1	10.1016/j.ejmech.2022.114961
	56598833	88301	None	0	Human	Functional	pKd	=	7.6	7.6	436	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	433	14	5	7	2.0	CCOCCOc1ccc(OCC(O)CNCCNC(=O)Nc2ccc(O)cc2)cc1	10.1021/jm400348g
	CHEMBL2348217	88301	None	0	Human	Functional	pKd	=	7.6	7.6	436	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	433	14	5	7	2.0	CCOCCOc1ccc(OCC(O)CNCCNC(=O)Nc2ccc(O)cc2)cc1	10.1021/jm400348g
	168613	60341	None	17	Guinea pig	Functional	pKd	=	7.6	7.6	-	0	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	316	6	2	8	0.5	CC(C)(C)NC[C@@H](O)COc1nsnc1N1CCOCC1	10.1021/jm00350a009
	CHEMBL1744069	60341	None	17	Guinea pig	Functional	pKd	=	7.6	7.6	-	0	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	316	6	2	8	0.5	CC(C)(C)NC[C@@H](O)COc1nsnc1N1CCOCC1	10.1021/jm00350a009
	12733306	60101	None	0	Guinea pig	Functional	pKd	=	6.6	6.6	-	0	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	368	5	1	6	2.5	COc1ccccc1N1CCN(CC(O)C2=COc3ccccc3O2)CC1	10.1021/jm00140a015
	CHEMBL173882	60101	None	0	Guinea pig	Functional	pKd	=	6.6	6.6	-	0	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	ChEMBL	368	5	1	6	2.5	COc1ccccc1N1CCN(CC(O)C2=COc3ccccc3O2)CC1	10.1021/jm00140a015
	2303	3187	None	44	Rat	Functional	pKd	=	5.6	5.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	4946	3187	None	44	Rat	Functional	pKd	=	5.6	5.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	564	3187	None	44	Rat	Functional	pKd	=	5.6	5.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	63	3187	None	44	Rat	Functional	pKd	=	5.6	5.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	91536	3187	None	44	Rat	Functional	pKd	=	5.6	5.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	CHEMBL27	3187	None	44	Rat	Functional	pKd	=	5.6	5.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	CHEMBL452861	3187	None	44	Rat	Functional	pKd	=	5.6	5.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	DB00571	3187	None	44	Rat	Functional	pKd	=	5.6	5.6	-	20	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm970338c
	10042467	1426	None	1	Guinea pig	Functional	pKd	=	4.6	4.6	-	2	Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	1203	1426	None	1	Guinea pig	Functional	pKd	=	4.6	4.6	-	2	Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	CHEMBL11553	1426	None	1	Guinea pig	Functional	pKd	=	4.6	4.6	-	2	Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	44371642	49232	None	0	Guinea pig	Functional	pKd	=	4.6	4.6	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	203	6	2	4	0.5	CC(C)NCC(O)COC(=O)C(C)C	10.1021/jm00387a006
	CHEMBL156271	49232	None	0	Guinea pig	Functional	pKd	=	4.6	4.6	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	203	6	2	4	0.5	CC(C)NCC(O)COC(=O)C(C)C	10.1021/jm00387a006
	12606702	12017	None	0	Guinea pig	Functional	pKd	=	6.6	6.6	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	242	5	2	4	2.1	CC(C)(C)NCC(O)CON=C1CCCCC1	10.1021/jm00180a007
	CHEMBL1161383	12017	None	0	Guinea pig	Functional	pKd	=	6.6	6.6	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	242	5	2	4	2.1	CC(C)(C)NCC(O)CON=C1CCCCC1	10.1021/jm00180a007
	CHEMBL1183312	12017	None	0	Guinea pig	Functional	pKd	=	6.6	6.6	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	242	5	2	4	2.1	CC(C)(C)NCC(O)CON=C1CCCCC1	10.1021/jm00180a007
	CHEMBL289868	12017	None	0	Guinea pig	Functional	pKd	=	6.6	6.6	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	242	5	2	4	2.1	CC(C)(C)NCC(O)CON=C1CCCCC1	10.1021/jm00180a007
	12606704	14321	None	0	Guinea pig	Functional	pKd	=	6.6	6.6	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	290	7	2	4	2.8	CC(/C=C/c1ccccc1)=N\OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL1161386	14321	None	0	Guinea pig	Functional	pKd	=	6.6	6.6	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	290	7	2	4	2.8	CC(/C=C/c1ccccc1)=N\OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL1199951	14321	None	0	Guinea pig	Functional	pKd	=	6.6	6.6	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	290	7	2	4	2.8	CC(/C=C/c1ccccc1)=N\OCC(O)CNC(C)(C)C	10.1021/jm00180a007
	44371312	49272	None	0	Guinea pig	Functional	pKd	=	4.6	4.6	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	203	5	2	4	0.7	CCC(=O)OCC(O)CNC(C)(C)C	10.1021/jm00387a006
	CHEMBL156304	49272	None	0	Guinea pig	Functional	pKd	=	4.6	4.6	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	203	5	2	4	0.7	CCC(=O)OCC(O)CNC(C)(C)C	10.1021/jm00387a006
	44264509	206146	None	0	Rat	Functional	pKd	=	5.5	5.5	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	429	14	2	4	4.5	CC(CCc1ccc(F)cc1)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL6749	206146	None	0	Rat	Functional	pKd	=	5.5	5.5	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	429	14	2	4	4.5	CC(CCc1ccc(F)cc1)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	3047492	206424	None	5	Guinea pig	Functional	pKd	=	5.5	5.5	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	293	10	2	4	2.4	CC(C)NCC(O)COc1ccc(COCC2CC2)cc1	10.1021/jm00389a008
	CHEMBL6939	206424	None	5	Guinea pig	Functional	pKd	=	5.5	5.5	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	293	10	2	4	2.4	CC(C)NCC(O)COc1ccc(COCC2CC2)cc1	10.1021/jm00389a008
	2303	3187	None	44	Guinea pig	Functional	pKd	=	8.5	8.5	-21	20	Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00373a008
	4946	3187	None	44	Guinea pig	Functional	pKd	=	8.5	8.5	-21	20	Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00373a008
	564	3187	None	44	Guinea pig	Functional	pKd	=	8.5	8.5	-21	20	Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00373a008
	63	3187	None	44	Guinea pig	Functional	pKd	=	8.5	8.5	-21	20	Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00373a008
	91536	3187	None	44	Guinea pig	Functional	pKd	=	8.5	8.5	-21	20	Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00373a008
	CHEMBL27	3187	None	44	Guinea pig	Functional	pKd	=	8.5	8.5	-21	20	Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00373a008
	CHEMBL452861	3187	None	44	Guinea pig	Functional	pKd	=	8.5	8.5	-21	20	Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00373a008
	DB00571	3187	None	44	Guinea pig	Functional	pKd	=	8.5	8.5	-21	20	Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00373a008
	54669764	65513	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	893	26	4	10	6.8	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNC[C@H](O)COc1cccc2ccccc12	10.1021/jm2008562
	CHEMBL1830491	65513	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	893	26	4	10	6.8	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNC[C@H](O)COc1cccc2ccccc12	10.1021/jm2008562
	56598967	88295	None	0	Human	Functional	pKd	=	8.5	8.5	2238	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	457	14	4	6	3.2	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccccc1	10.1021/jm400348g
	CHEMBL2348211	88295	None	0	Human	Functional	pKd	=	8.5	8.5	2238	3	Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs	ChEMBL	457	14	4	6	3.2	O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccccc1	10.1021/jm400348g
	54757026	65511	None	0	Human	Functional	pKd	=	7.5	7.5	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	833	22	4	8	7.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	CHEMBL1830489	65511	None	0	Human	Functional	pKd	=	7.5	7.5	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	833	22	4	8	7.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	54758320	65539	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	794	20	5	8	6.1	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCNCC(O)COc1cccc2[nH]ccc12	10.1021/jm2008562
	CHEMBL1830620	65539	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	794	20	5	8	6.1	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCNCC(O)COc1cccc2[nH]ccc12	10.1021/jm2008562
	12606706	93286	None	0	Guinea pig	Functional	pKd	=	6.5	6.5	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	202	5	2	4	1.1	CC(C)=NOCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL24480	93286	None	0	Guinea pig	Functional	pKd	=	6.5	6.5	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	202	5	2	4	1.1	CC(C)=NOCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL555848	93286	None	0	Guinea pig	Functional	pKd	=	6.5	6.5	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	202	5	2	4	1.1	CC(C)=NOCC(O)CNC(C)(C)C	10.1021/jm00180a007
	172445308	195059	None	0	Human	Functional	pKd	=	5.5	5.5	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	413	8	2	7	2.7	CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCc3ccc4c(c3)OCO4)cc2O1	10.1016/j.ejmech.2022.114961
	CHEMBL5395772	195059	None	0	Human	Functional	pKd	=	5.5	5.5	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	413	8	2	7	2.7	CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCc3ccc4c(c3)OCO4)cc2O1	10.1016/j.ejmech.2022.114961
	1531	2266	None	40	Guinea pig	Functional	pKd	=	7.5	7.5	-	12	The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1021/jm00156a019
	3869	2266	None	40	Guinea pig	Functional	pKd	=	7.5	7.5	-	12	The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1021/jm00156a019
	3869.0	2266	None	40	Guinea pig	Functional	pKd	=	7.5	7.5	-	12	The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1021/jm00156a019
	7207	2266	None	40	Guinea pig	Functional	pKd	=	7.5	7.5	-	12	The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1021/jm00156a019
	CHEMBL429	2266	None	40	Guinea pig	Functional	pKd	=	7.5	7.5	-	12	The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1021/jm00156a019
	DB00598	2266	None	40	Guinea pig	Functional	pKd	=	7.5	7.5	-	12	The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1021/jm00156a019
	172461924	196811	None	0	Human	Functional	pKd	=	5.5	5.5	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	413	7	2	7	2.6	CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCC3COc4ccccc4O3)cc2O1	10.1016/j.ejmech.2022.114961
	CHEMBL5432691	196811	None	0	Human	Functional	pKd	=	5.5	5.5	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	413	7	2	7	2.6	CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCC3COc4ccccc4O3)cc2O1	10.1016/j.ejmech.2022.114961
	172470154	197049	None	0	Human	Functional	pKd	=	5.5	5.5	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	396	9	3	6	2.3	CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc3ccc(=O)oc3c2)cc1	10.1016/j.ejmech.2022.114961
	CHEMBL5437540	197049	None	0	Human	Functional	pKd	=	5.5	5.5	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	396	9	3	6	2.3	CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc3ccc(=O)oc3c2)cc1	10.1016/j.ejmech.2022.114961
	121848	130778	None	3	Guinea pig	Functional	pKd	=	7.5	7.5	-	2	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	324	5	2	4	3.2	CC(C)(C)NCC(O)CON=C1c2ccccc2-c2ccccc21	10.1021/jm00350a009
	CHEMBL368457	130778	None	3	Guinea pig	Functional	pKd	=	7.5	7.5	-	2	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	324	5	2	4	3.2	CC(C)(C)NCC(O)CON=C1c2ccccc2-c2ccccc21	10.1021/jm00350a009
	10028830	2246	None	31	Human	Functional	pKd	=	6.5	6.5	-186	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	497	13	4	6	2.7	O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1	10.1016/j.ejmech.2022.114961
	3932	2246	None	31	Human	Functional	pKd	=	6.5	6.5	-186	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	497	13	4	6	2.7	O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1	10.1016/j.ejmech.2022.114961
	CHEMBL4238084	2246	None	31	Human	Functional	pKd	=	6.5	6.5	-186	3	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	497	13	4	6	2.7	O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1	10.1016/j.ejmech.2022.114961
	44264298	13379	None	0	Rat	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	346	12	2	5	2.7	CC(CC#N)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL1192477	13379	None	0	Rat	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	346	12	2	5	2.7	CC(CC#N)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL543717	13379	None	0	Rat	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	346	12	2	5	2.7	CC(CC#N)NCC(O)COc1ccc(CCOCC2CCC2)cc1	10.1021/jm00389a008
	12778440	60192	None	0	Guinea pig	Functional	pKd	=	7.5	7.5	-	0	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	338	7	2	4	3.6	CCC(C)(C)NCC(O)CON=C1c2ccccc2-c2ccccc21	10.1021/jm00350a009
	CHEMBL173976	60192	None	0	Guinea pig	Functional	pKd	=	7.5	7.5	-	0	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	338	7	2	4	3.6	CCC(C)(C)NCC(O)CON=C1c2ccccc2-c2ccccc21	10.1021/jm00350a009
	54756929	65510	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	805	20	4	8	6.7	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	CHEMBL1830488	65510	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	805	20	4	8	6.7	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	44263933	13662	None	0	Rat	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	10	2	4	2.7	CC(C)NCC(O)COc1ccc(COCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL1194583	13662	None	0	Rat	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	10	2	4	2.7	CC(C)NCC(O)COc1ccc(COCC2CCC2)cc1	10.1021/jm00389a008
	CHEMBL552898	13662	None	0	Rat	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	307	10	2	4	2.7	CC(C)NCC(O)COc1ccc(COCC2CCC2)cc1	10.1021/jm00389a008
	172455968	196414	None	0	Human	Functional	pKd	=	5.4	5.4	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	371	7	2	7	1.4	O=C1COc2cc(OC[C@@H](O)CNCC3COc4ccccc4O3)ccc21	10.1016/j.ejmech.2022.114961
	CHEMBL5423415	196414	None	0	Human	Functional	pKd	=	5.4	5.4	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	371	7	2	7	1.4	O=C1COc2cc(OC[C@@H](O)CNCC3COc4ccccc4O3)ccc21	10.1016/j.ejmech.2022.114961
	172461561	196828	None	0	Human	Functional	pKd	=	5.4	5.4	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	413	7	2	7	2.6	CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCC3COc4ccccc4O3)cc2O1	10.1016/j.ejmech.2022.114961
	CHEMBL5432967	196828	None	0	Human	Functional	pKd	=	5.4	5.4	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	413	7	2	7	2.6	CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCC3COc4ccccc4O3)cc2O1	10.1016/j.ejmech.2022.114961
	5311452	3671	None	7	Human	Functional	pKd	=	7.4	7.4	-5	4	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	325	7	2	3	3.7	CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O	10.1016/j.ejmech.2022.114961
	547	3671	None	7	Human	Functional	pKd	=	7.4	7.4	-5	4	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	325	7	2	3	3.7	CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O	10.1016/j.ejmech.2022.114961
	CHEMBL1326499	3671	None	7	Human	Functional	pKd	=	7.4	7.4	-5	4	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	325	7	2	3	3.7	CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O	10.1016/j.ejmech.2022.114961
	2447484	102823	None	0	Guinea pig	Functional	pKd	=	7.4	7.4	-	2	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	324	5	2	4	3.2	CC(C)(C)NC[C@H](O)CON=C1c2ccccc2-c2ccccc21	10.1021/jm00350a009
	CHEMBL305153	102823	None	0	Guinea pig	Functional	pKd	=	7.4	7.4	-	2	Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria	ChEMBL	324	5	2	4	3.2	CC(C)(C)NC[C@H](O)CON=C1c2ccccc2-c2ccccc21	10.1021/jm00350a009
	54758415	65540	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	882	26	5	10	6.1	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2[nH]ccc12	10.1021/jm2008562
	CHEMBL1830621	65540	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	882	26	5	10	6.1	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2[nH]ccc12	10.1021/jm2008562
	12606709	14348	None	0	Guinea pig	Functional	pKd	=	5.4	5.4	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	296	5	2	4	3.0	CC(C)(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C	10.1021/jm00180a007
	CHEMBL1161382	14348	None	0	Guinea pig	Functional	pKd	=	5.4	5.4	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	296	5	2	4	3.0	CC(C)(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C	10.1021/jm00180a007
	CHEMBL1200073	14348	None	0	Guinea pig	Functional	pKd	=	5.4	5.4	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	296	5	2	4	3.0	CC(C)(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C	10.1021/jm00180a007
	3047500	13282	None	0	Guinea pig	Functional	pKd	=	5.4	5.4	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	349	11	2	4	3.6	CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1	10.1021/jm00389a008
	CHEMBL1191645	13282	None	0	Guinea pig	Functional	pKd	=	5.4	5.4	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	349	11	2	4	3.6	CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1	10.1021/jm00389a008
	CHEMBL542776	13282	None	0	Guinea pig	Functional	pKd	=	5.4	5.4	-	0	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	349	11	2	4	3.6	CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1	10.1021/jm00389a008
	44371514	11705	None	0	Guinea pig	Functional	pKd	=	6.4	6.4	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	216	8	2	4	1.5	CCC/C(C)=N\OCC(O)CNC(C)C	10.1021/jm00180a007
	CHEMBL1181235	11705	None	0	Guinea pig	Functional	pKd	=	6.4	6.4	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	216	8	2	4	1.5	CCC/C(C)=N\OCC(O)CNC(C)C	10.1021/jm00180a007
	CHEMBL160282	11705	None	0	Guinea pig	Functional	pKd	=	6.4	6.4	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	216	8	2	4	1.5	CCC/C(C)=N\OCC(O)CNC(C)C	10.1021/jm00180a007
	172465355	196533	None	0	Human	Functional	pKd	=	5.4	5.4	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	383	9	2	5	3.4	CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCCc3ccccc3)cc2O1	10.1016/j.ejmech.2022.114961
	CHEMBL5426087	196533	None	0	Human	Functional	pKd	=	5.4	5.4	-	0	Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation	ChEMBL	383	9	2	5	3.4	CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCCc3ccccc3)cc2O1	10.1016/j.ejmech.2022.114961
	127940	207342	None	5	Guinea pig	Functional	pKd	=	7.4	7.4	-	0	The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptorThe compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor	ChEMBL	351	8	4	3	2.9	CC(CCc1ccccc1)NCC(O)c1cc(C(N)=O)c2[nH]ccc2c1	10.1021/jm00156a019
	CHEMBL7585	207342	None	5	Guinea pig	Functional	pKd	=	7.4	7.4	-	0	The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptorThe compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor	ChEMBL	351	8	4	3	2.9	CC(CCc1ccccc1)NCC(O)c1cc(C(N)=O)c2[nH]ccc2c1	10.1021/jm00156a019
	2369	622	None	46	Guinea pig	Functional	pKd	=	5.4	5.4	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	2369.0	622	None	46	Guinea pig	Functional	pKd	=	5.4	5.4	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	356	622	None	46	Guinea pig	Functional	pKd	=	5.4	5.4	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	549	622	None	46	Guinea pig	Functional	pKd	=	5.4	5.4	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	CHEMBL423	622	None	46	Guinea pig	Functional	pKd	=	5.4	5.4	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	DB00195	622	None	46	Guinea pig	Functional	pKd	=	5.4	5.4	-	3	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	ChEMBL	307	11	2	4	2.4	OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C	10.1021/jm00389a008
	137	370	None	37	Human	Functional	pKd	=	8.4	8.4	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	2119	370	None	37	Human	Functional	pKd	=	8.4	8.4	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	563	370	None	37	Human	Functional	pKd	=	8.4	8.4	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	66368	370	None	37	Human	Functional	pKd	=	8.4	8.4	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	CHEMBL266195	370	None	37	Human	Functional	pKd	=	8.4	8.4	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	DB00866	370	None	37	Human	Functional	pKd	=	8.4	8.4	-3	8	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1021/jm2008562
	2303	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	4946	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	564	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	63	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	91536	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	CHEMBL27	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	CHEMBL452861	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	DB00571	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	2303	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	4946	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	564	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	63	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	91536	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	CHEMBL27	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	CHEMBL452861	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	DB00571	3187	None	44	Rat	Functional	pKd	=	8.4	8.4	-	20	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/jm00389a008
	54757232	65537	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	883	28	4	10	6.3	C=CCc1ccccc1OC[C@@H](O)CNCCOCCOCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1	10.1021/jm2008562
	CHEMBL1830618	65537	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	883	28	4	10	6.3	C=CCc1ccccc1OC[C@@H](O)CNCCOCCOCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1	10.1021/jm2008562
	54757126	65514	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	893	26	4	10	6.8	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	CHEMBL1830492	65514	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	893	26	4	10	6.8	O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2ccccc12	10.1021/jm2008562
	44264188	206368	None	0	Rat	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	325	10	2	4	2.1	CC(C)NCC(O)COc1ccc(C[S+]([O-])CC2CC2)cc1	10.1021/jm00389a008
	CHEMBL6902	206368	None	0	Rat	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL	325	10	2	4	2.1	CC(C)NCC(O)COc1ccc(C[S+]([O-])CC2CC2)cc1	10.1021/jm00389a008
	54757229	65536	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	795	22	4	8	6.3	C=CCc1ccccc1OCC(O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1	10.1021/jm2008562
	CHEMBL1830617	65536	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	795	22	4	8	6.3	C=CCc1ccccc1OCC(O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1	10.1021/jm2008562
	12606687	12225	None	0	Guinea pig	Functional	pKd	=	5.4	5.4	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	175	6	2	3	0.8	CC(C)NCC(O)COC(C)C	10.1021/jm00180a007
	CHEMBL1184385	12225	None	0	Guinea pig	Functional	pKd	=	5.4	5.4	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	175	6	2	3	0.8	CC(C)NCC(O)COC(C)C	10.1021/jm00180a007
	CHEMBL346972	12225	None	0	Guinea pig	Functional	pKd	=	5.4	5.4	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	175	6	2	3	0.8	CC(C)NCC(O)COC(C)C	10.1021/jm00180a007
	134495	749	None	18	Guinea pig	Functional	pKd	=	4.4	4.4	-	2	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	267	5	2	4	2.5	COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC	10.1021/jm00387a006
	18026	749	None	18	Guinea pig	Functional	pKd	=	4.4	4.4	-	2	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	267	5	2	4	2.5	COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC	10.1021/jm00387a006
	9809	749	None	18	Guinea pig	Functional	pKd	=	4.4	4.4	-	2	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	267	5	2	4	2.5	COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC	10.1021/jm00387a006
	CHEMBL289093	749	None	18	Guinea pig	Functional	pKd	=	4.4	4.4	-	2	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	267	5	2	4	2.5	COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC	10.1021/jm00387a006
	134495	749	None	18	Guinea pig	Functional	pKd	=	4.4	4.4	-	2	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	267	5	2	4	2.5	COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC	10.1021/jm00380a001
	18026	749	None	18	Guinea pig	Functional	pKd	=	4.4	4.4	-	2	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	267	5	2	4	2.5	COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC	10.1021/jm00380a001
	9809	749	None	18	Guinea pig	Functional	pKd	=	4.4	4.4	-	2	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	267	5	2	4	2.5	COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC	10.1021/jm00380a001
	CHEMBL289093	749	None	18	Guinea pig	Functional	pKd	=	4.4	4.4	-	2	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	267	5	2	4	2.5	COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC	10.1021/jm00380a001
	44371383	49628	None	1	Guinea pig	Functional	pKd	=	6.3	6.3	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	257	5	2	5	1.7	CC(C)(C)NCC(O)COC(=O)c1cccs1	10.1021/jm00387a006
	CHEMBL156603	49628	None	1	Guinea pig	Functional	pKd	=	6.3	6.3	-	0	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	ChEMBL	257	5	2	5	1.7	CC(C)(C)NCC(O)COC(=O)c1cccs1	10.1021/jm00387a006
	10447834	1933	None	1	Guinea pig	Functional	pKd	=	4.3	4.3	-	3	Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	4026	1933	None	1	Guinea pig	Functional	pKd	=	4.3	4.3	-	3	Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275507	1933	None	1	Guinea pig	Functional	pKd	=	4.3	4.3	-	3	Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	54757129	65515	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	795	22	4	8	6.3	C=CCc1ccccc1OC[C@@H](O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1	10.1021/jm2008562
	CHEMBL1830493	65515	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	ChEMBL	795	22	4	8	6.3	C=CCc1ccccc1OC[C@@H](O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1	10.1021/jm2008562
	44287469	12001	None	0	Guinea pig	Functional	pKd	=	5.3	5.3	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	258	9	2	4	2.7	CCCC(CCC)=NOCC(O)CNC(C)(C)C	10.1021/jm00380a001
	CHEMBL1183268	12001	None	0	Guinea pig	Functional	pKd	=	5.3	5.3	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	258	9	2	4	2.7	CCCC(CCC)=NOCC(O)CNC(C)(C)C	10.1021/jm00380a001
	CHEMBL287766	12001	None	0	Guinea pig	Functional	pKd	=	5.3	5.3	-	0	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	ChEMBL	258	9	2	4	2.7	CCCC(CCC)=NOCC(O)CNC(C)(C)C	10.1021/jm00380a001
	44288489	169006	None	0	Rat	Functional	pKd	=	7.3	7.3	-	0	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	314	8	3	5	2.5	OC(CNc1nc2ccccc2[nH]1)CON=C(C1CC1)C1CC1	10.1021/jm970338c
	CHEMBL43850	169006	None	0	Rat	Functional	pKd	=	7.3	7.3	-	0	Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)	ChEMBL	314	8	3	5	2.5	OC(CNc1nc2ccccc2[nH]1)CON=C(C1CC1)C1CC1	10.1021/jm970338c
	12606684	96127	None	0	Guinea pig	Functional	pKd	=	6.3	6.3	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	203	6	2	3	1.4	CC(C)COCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL1161388	96127	None	0	Guinea pig	Functional	pKd	=	6.3	6.3	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	203	6	2	3	1.4	CC(C)COCC(O)CNC(C)(C)C	10.1021/jm00180a007
	CHEMBL26003	96127	None	0	Guinea pig	Functional	pKd	=	6.3	6.3	-	0	Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig	ChEMBL	203	6	2	3	1.4	CC(C)COCC(O)CNC(C)(C)C	10.1021/jm00180a007
	60657	14492	None	24	Rat	Functional

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Ligand source activities (1 row/activity)