Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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DOI

2583 208352 None 32 Human Functional pAC50 = 9 9.0 6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 292 5 3 4 1.7 CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2 10.1038/s41467-023-40064-9
2583.0 208352 None 32 Human Functional pAC50 = 9 9.0 6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 292 5 3 4 1.7 CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2 10.1038/s41467-023-40064-9
CHEMBL839 208352 None 32 Human Functional pAC50 = 9 9.0 6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 292 5 3 4 1.7 CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2 10.1038/s41467-023-40064-9
DB00521 208352 None 32 Human Functional pAC50 = 9 9.0 6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 292 5 3 4 1.7 CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2 10.1038/s41467-023-40064-9
1978 250 None 42 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
1978.0 250 None 42 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
40 250 None 42 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
7107 250 None 42 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
CHEMBL642 250 None 42 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
DB01193 250 None 42 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
10184665 3991 None 42 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
10184665.0 3991 None 42 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
4799 3991 None 42 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
7353 3991 None 42 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
CHEMBL1198857 3991 None 42 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
DB09082 3991 None 42 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
216416 111644 None 40 Human Functional pAC50 = 5 5.0 -117 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL328190 111644 None 40 Human Functional pAC50 = 5 5.0 -117 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
11823027 192725 None 29 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
11823027.0 192725 None 29 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
4411 192725 None 29 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
4411.0 192725 None 29 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
CHEMBL3246778 192725 None 29 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
CHEMBL521606 192725 None 29 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
DB01203 192725 None 29 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
72093 35070 None 5 Human Functional pAC50 = 5.0 5.0 -10 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 35070 None 5 Human Functional pAC50 = 5.0 5.0 -10 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 35070 None 5 Human Functional pAC50 = 5.0 5.0 -10 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
4418 34231 None 58 Human Functional pAC50 = 6.0 6.0 -19 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1038/s41467-023-40064-9
4418.0 34231 None 58 Human Functional pAC50 = 6.0 6.0 -19 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1038/s41467-023-40064-9
CHEMBL142635 34231 None 58 Human Functional pAC50 = 6.0 6.0 -19 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1038/s41467-023-40064-9
DB12092 34231 None 58 Human Functional pAC50 = 6.0 6.0 -19 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1038/s41467-023-40064-9
12582 950 None 27 Human Functional pAC50 = 7.0 7.0 -1 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 276 3 3 3 3.0 CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O 10.1038/s41467-023-40064-9
2783 950 None 27 Human Functional pAC50 = 7.0 7.0 -1 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 276 3 3 3 3.0 CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O 10.1038/s41467-023-40064-9
2783.0 950 None 27 Human Functional pAC50 = 7.0 7.0 -1 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 276 3 3 3 3.0 CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O 10.1038/s41467-023-40064-9
CHEMBL49080 950 None 27 Human Functional pAC50 = 7.0 7.0 -1 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 276 3 3 3 3.0 CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O 10.1038/s41467-023-40064-9
DB01407 950 None 27 Human Functional pAC50 = 7.0 7.0 -1 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 276 3 3 3 3.0 CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O 10.1038/s41467-023-40064-9
3083544 26817 None 34 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
3083544.0 26817 None 34 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1200811 26817 None 34 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1363 26817 None 34 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1951071 26817 None 34 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL605993 26817 None 34 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
DB00983 26817 None 34 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
DB01274 26817 None 34 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
100 3805 None 44 Human Functional pAC50 = 4.9 4.9 -2754 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
2637 3805 None 44 Human Functional pAC50 = 4.9 4.9 -2754 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
5452 3805 None 44 Human Functional pAC50 = 4.9 4.9 -2754 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
CHEMBL479 3805 None 44 Human Functional pAC50 = 4.9 4.9 -2754 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
DB00679 3805 None 44 Human Functional pAC50 = 4.9 4.9 -2754 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
11980903 14498 None 13 Human Functional pAC50 = 4.9 4.9 -354 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
22526 14498 None 13 Human Functional pAC50 = 4.9 4.9 -354 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5281035 14498 None 13 Human Functional pAC50 = 4.9 4.9 -354 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201303 14498 None 13 Human Functional pAC50 = 4.9 4.9 -354 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
2713 207729 None 57 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5353524 207729 None 57 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5360566 207729 None 57 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
88536661 207729 None 57 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
9552079 207729 None 57 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1330113 207729 None 57 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL790 207729 None 57 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
6436135 99626 None 31 Human Functional pAC50 = 4.9 4.9 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 9 2 4 5.8 CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL283754 99626 None 31 Human Functional pAC50 = 4.9 4.9 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 9 2 4 5.8 CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O 10.1038/s41467-023-40064-9
5906 14501 None 15 Human Functional pAC50 = 4.8 4.8 -1 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 167 2 3 3 0.8 C[C@H](N)[C@H](O)c1cccc(O)c1 10.1038/s41467-023-40064-9
5906.0 14501 None 15 Human Functional pAC50 = 4.8 4.8 -1 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 167 2 3 3 0.8 C[C@H](N)[C@H](O)c1cccc(O)c1 10.1038/s41467-023-40064-9
CHEMBL1201319 14501 None 15 Human Functional pAC50 = 4.8 4.8 -1 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 167 2 3 3 0.8 C[C@H](N)[C@H](O)c1cccc(O)c1 10.1038/s41467-023-40064-9
DB00610 14501 None 15 Human Functional pAC50 = 4.8 4.8 -1 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 167 2 3 3 0.8 C[C@H](N)[C@H](O)c1cccc(O)c1 10.1038/s41467-023-40064-9
202 1508 None 46 Human Functional pAC50 = 4.8 4.8 -10 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
60835 1508 None 46 Human Functional pAC50 = 4.8 4.8 -10 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
972 1508 None 46 Human Functional pAC50 = 4.8 4.8 -10 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1175 1508 None 46 Human Functional pAC50 = 4.8 4.8 -10 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
DB00476 1508 None 46 Human Functional pAC50 = 4.8 4.8 -10 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
3191 102913 None 65 Human Functional pAC50 = 4.8 4.8 -831 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
3191.0 102913 None 65 Human Functional pAC50 = 4.8 4.8 -831 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
CHEMBL305660 102913 None 65 Human Functional pAC50 = 4.8 4.8 -831 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
DB11742 102913 None 65 Human Functional pAC50 = 4.8 4.8 -831 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
1786 2520 None 51 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
4171 2520 None 51 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
4171.0 2520 None 51 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
553 2520 None 51 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
CHEMBL13 2520 None 51 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
DB00264 2520 None 51 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
6436173 55132 None 30 Human Functional pAC50 = 4.8 4.8 -4 22
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1617 55132 None 30 Human Functional pAC50 = 4.8 4.8 -4 22
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
2274 3173 None 38 Human Functional pAC50 = 4.8 4.8 -1047 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
4917 3173 None 38 Human Functional pAC50 = 4.8 4.8 -1047 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
4917.0 3173 None 38 Human Functional pAC50 = 4.8 4.8 -1047 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
7279 3173 None 38 Human Functional pAC50 = 4.8 4.8 -1047 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL728 3173 None 38 Human Functional pAC50 = 4.8 4.8 -1047 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00433 3173 None 38 Human Functional pAC50 = 4.8 4.8 -1047 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
3464 3172 None 21 Human Functional pAC50 = 4.8 4.8 -1348 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 290 5 4 4 2.0 CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C 10.1038/s41467-023-40064-9
4916 3172 None 21 Human Functional pAC50 = 4.8 4.8 -1348 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 290 5 4 4 2.0 CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C 10.1038/s41467-023-40064-9
4916.0 3172 None 21 Human Functional pAC50 = 4.8 4.8 -1348 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 290 5 4 4 2.0 CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C 10.1038/s41467-023-40064-9
CHEMBL160519 3172 None 21 Human Functional pAC50 = 4.8 4.8 -1348 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 290 5 4 4 2.0 CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C 10.1038/s41467-023-40064-9
DB01366 3172 None 21 Human Functional pAC50 = 4.8 4.8 -1348 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 290 5 4 4 2.0 CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C 10.1038/s41467-023-40064-9
31729 208242 None 9 Human Functional pAC50 = 4.8 4.8 -707 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 287 6 4 4 2.4 CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL83063 208242 None 9 Human Functional pAC50 = 4.8 4.8 -707 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 287 6 4 4 2.4 CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1 10.1038/s41467-023-40064-9
3926 209699 None 30 Human Functional pAC50 = 4.8 4.8 -27 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL92870 209699 None 30 Human Functional pAC50 = 4.8 4.8 -27 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
1016 3747 None 45 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2561 3747 None 45 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2733526 3747 None 45 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
5384 3747 None 45 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL83 3747 None 45 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
DB00675 3747 None 45 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2267 559 None 45 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
2267.0 559 None 45 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
271 559 None 45 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
7121 559 None 45 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
CHEMBL639 559 None 45 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
DB00972 559 None 45 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
2435 3590 None 59 Human Functional pAC50 = 4.8 4.8 -4365 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
60149 3590 None 59 Human Functional pAC50 = 4.8 4.8 -4365 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
98 3590 None 59 Human Functional pAC50 = 4.8 4.8 -4365 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
CHEMBL12713 3590 None 59 Human Functional pAC50 = 4.8 4.8 -4365 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
DB06144 3590 None 59 Human Functional pAC50 = 4.8 4.8 -4365 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
2540 4402 None 68 Human Functional pAC50 = 4.8 4.8 -2570 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 4402 None 68 Human Functional pAC50 = 4.8 4.8 -2570 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
64139 84819 None 58 Human Functional pAC50 = 4.7 4.7 -3 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
CHEMBL223228 84819 None 58 Human Functional pAC50 = 4.7 4.7 -3 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
451668 14463 None 65 Human Functional pAC50 = 4.7 4.7 - 1
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 228 2 3 8 -2.1 Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 10.1038/s41467-023-40064-9
CHEMBL1201129 14463 None 65 Human Functional pAC50 = 4.7 4.7 - 1
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 228 2 3 8 -2.1 Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 10.1038/s41467-023-40064-9
33624 3821 None 21 Human Functional pAC50 = 8.6 8.6 -5 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
33624.0 3821 None 21 Human Functional pAC50 = 8.6 8.6 -5 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
4061 3821 None 21 Human Functional pAC50 = 8.6 8.6 -5 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
565 3821 None 21 Human Functional pAC50 = 8.6 8.6 -5 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL499 3821 None 21 Human Functional pAC50 = 8.6 8.6 -5 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
DB00373 3821 None 21 Human Functional pAC50 = 8.6 8.6 -5 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
1222 1664 None 37 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3396 1664 None 37 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3396.0 1664 None 37 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
85 1664 None 37 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL46516 1664 None 37 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
DB04842 1664 None 37 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
1836 2592 None 44 Human Functional pAC50 = 4.7 4.7 -39810 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
3340 2592 None 44 Human Functional pAC50 = 4.7 4.7 -39810 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
5281040 2592 None 44 Human Functional pAC50 = 4.7 4.7 -39810 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
5281040.0 2592 None 44 Human Functional pAC50 = 4.7 4.7 -39810 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
CHEMBL787 2592 None 44 Human Functional pAC50 = 4.7 4.7 -39810 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
DB00471 2592 None 44 Human Functional pAC50 = 4.7 4.7 -39810 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
5591 157623 None 57 Human Functional pAC50 = 4.7 4.7 -12 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
CHEMBL408 157623 None 57 Human Functional pAC50 = 4.7 4.7 -12 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
3151 1462 None 65 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
3151.0 1462 None 65 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
945 1462 None 65 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
965 1462 None 65 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL219916 1462 None 65 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01184 1462 None 65 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2303 3187 None 44 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
4946 3187 None 44 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
564 3187 None 44 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
63 3187 None 44 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
91536 3187 None 44 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL27 3187 None 44 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL452861 3187 None 44 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
DB00571 3187 None 44 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
5282219 35878 None 48 Human Functional pAC50 = 4.7 4.7 -3 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 450 12 1 5 5.7 CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 10.1038/s41467-023-40064-9
CHEMBL1441961 35878 None 48 Human Functional pAC50 = 4.7 4.7 -3 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 450 12 1 5 5.7 CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 10.1038/s41467-023-40064-9
105 3461 None 54 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
2083 3461 None 54 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
2083.0 3461 None 54 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
558 3461 None 54 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
CHEMBL714 3461 None 54 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
DB01001 3461 None 54 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
11976 920 None 44 Human Functional pAC50 = 4.7 4.7 -7244 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
667467 920 None 44 Human Functional pAC50 = 4.7 4.7 -7244 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
667467.0 920 None 44 Human Functional pAC50 = 4.7 4.7 -7244 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
CHEMBL908 920 None 44 Human Functional pAC50 = 4.7 4.7 -7244 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
DB01239 920 None 44 Human Functional pAC50 = 4.7 4.7 -7244 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
155774 4096 None 34 Human Functional pAC50 = 6.7 6.7 38 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1038/s41467-023-40064-9
2848 4096 None 34 Human Functional pAC50 = 6.7 6.7 38 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1038/s41467-023-40064-9
538 4096 None 34 Human Functional pAC50 = 6.7 6.7 38 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1038/s41467-023-40064-9
CHEMBL75753 4096 None 34 Human Functional pAC50 = 6.7 6.7 38 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1038/s41467-023-40064-9
DB13781 4096 None 34 Human Functional pAC50 = 6.7 6.7 38 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1038/s41467-023-40064-9
180 401 None 38 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
200 401 None 38 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
2160 401 None 38 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
2160.0 401 None 38 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL629 401 None 38 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00321 401 None 38 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
3689 102826 None 36 Human Functional pAC50 = 4.6 4.6 -3311 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 5 2 3 3.8 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL1372983 102826 None 36 Human Functional pAC50 = 4.6 4.6 -3311 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 5 2 3 3.8 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL305187 102826 None 36 Human Functional pAC50 = 4.6 4.6 -3311 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 5 2 3 3.8 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
1971 2866 None 32 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
2404 2866 None 32 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
4543 2866 None 32 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
4543.0 2866 None 32 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL445 2866 None 32 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
DB00540 2866 None 32 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
5482 14425 None 55 Human Functional pAC50 = 4.6 4.6 -13 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 6 0 4 5.9 Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1200438 14425 None 55 Human Functional pAC50 = 4.6 4.6 -13 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 6 0 4 5.9 Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
2419 3463 None 53 Human Functional pAC50 = 5.6 5.6 -977 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
5152 3463 None 53 Human Functional pAC50 = 5.6 5.6 -977 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
5152.0 3463 None 53 Human Functional pAC50 = 5.6 5.6 -977 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
559 3463 None 53 Human Functional pAC50 = 5.6 5.6 -977 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
CHEMBL1263 3463 None 53 Human Functional pAC50 = 5.6 5.6 -977 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
DB00938 3463 None 53 Human Functional pAC50 = 5.6 5.6 -977 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
129211 3749 None 48 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
129211.0 3749 None 48 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
2562 3749 None 48 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
488 3749 None 48 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
CHEMBL836 3749 None 48 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
DB00706 3749 None 48 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
26987 949 None 27 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
26987.0 949 None 27 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
6063 949 None 27 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
671 949 None 27 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
CHEMBL1626 949 None 27 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
DB00283 949 None 27 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
4640 78295 None 23 Human Functional pAC50 = 4.6 4.6 -218 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 6 1 4 3.9 COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC 10.1038/s41467-023-40064-9
CHEMBL2107011 78295 None 23 Human Functional pAC50 = 4.6 4.6 -218 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 6 1 4 3.9 COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC 10.1038/s41467-023-40064-9
4486 123049 None 18 Human Functional pAC50 = 4.6 4.6 - 1
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 11 2 9 0.3 Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O 10.1038/s41467-023-40064-9
CHEMBL360861 123049 None 18 Human Functional pAC50 = 4.6 4.6 - 1
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 11 2 9 0.3 Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O 10.1038/s41467-023-40064-9
1549120 198942 None 55 Human Functional pAC50 = 4.6 4.6 -17 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56337 198942 None 55 Human Functional pAC50 = 4.6 4.6 -17 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
2372 106524 None 30 Human Functional pAC50 = 7.6 7.6 12 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 345 10 2 5 2.6 COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC 10.1038/s41467-023-40064-9
CHEMBL314010 106524 None 30 Human Functional pAC50 = 7.6 7.6 12 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 345 10 2 5 2.6 COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC 10.1038/s41467-023-40064-9
5606 10195 None 41 Human Functional pAC50 = 5.6 5.6 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 227 3 2 2 2.8 CC(C)(C)NCC(O)c1ccccc1Cl 10.1038/s41467-023-40064-9
5606.0 10195 None 41 Human Functional pAC50 = 5.6 5.6 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 227 3 2 2 2.8 CC(C)(C)NCC(O)c1ccccc1Cl 10.1038/s41467-023-40064-9
CHEMBL1159717 10195 None 41 Human Functional pAC50 = 5.6 5.6 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 227 3 2 2 2.8 CC(C)(C)NCC(O)c1ccccc1Cl 10.1038/s41467-023-40064-9
DB12248 10195 None 41 Human Functional pAC50 = 5.6 5.6 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 227 3 2 2 2.8 CC(C)(C)NCC(O)c1ccccc1Cl 10.1038/s41467-023-40064-9
65948 18563 None 62 Human Functional pAC50 = 4.6 4.6 -12 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
CHEMBL1275868 18563 None 62 Human Functional pAC50 = 4.6 4.6 -12 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
4908 188914 None 51 Human Functional pAC50 = 4.6 4.6 -5 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 4 2.8 COc1cc(NC(C)CCCN)c2ncccc2c1 10.1038/s41467-023-40064-9
CHEMBL506 188914 None 51 Human Functional pAC50 = 4.6 4.6 -5 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 4 2.8 COc1cc(NC(C)CCCN)c2ncccc2c1 10.1038/s41467-023-40064-9
4452 2762 None 13 Human Functional pAC50 = 5.6 5.6 -8912 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
983 2762 None 13 Human Functional pAC50 = 5.6 5.6 -8912 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
CHEMBL20734 2762 None 13 Human Functional pAC50 = 5.6 5.6 -8912 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
2470 3653 None 40 Human Functional pAC50 = 5.6 5.6 -46773 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3300 3653 None 40 Human Functional pAC50 = 5.6 5.6 -46773 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
5265 3653 None 40 Human Functional pAC50 = 5.6 5.6 -46773 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
99 3653 None 40 Human Functional pAC50 = 5.6 5.6 -46773 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL267930 3653 None 40 Human Functional pAC50 = 5.6 5.6 -46773 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
216239 23803 None 71 Human Functional pAC50 = 4.6 4.6 -15 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1200485 23803 None 71 Human Functional pAC50 = 4.6 4.6 -15 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1336 23803 None 71 Human Functional pAC50 = 4.6 4.6 -15 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
3760 50314 None 27 Human Functional pAC50 = 4.6 4.6 -3 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 414 6 0 3 6.5 Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1571863 50314 None 27 Human Functional pAC50 = 4.6 4.6 -3 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 414 6 0 3 6.5 Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
30323 62505 None 35 Human Functional pAC50 = 4.6 4.6 -14 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL1563 62505 None 35 Human Functional pAC50 = 4.6 4.6 -14 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL178 62505 None 35 Human Functional pAC50 = 4.6 4.6 -14 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
135398735 137055 None 20 Human Functional pAC50 = 4.6 4.6 -12 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
136262914 137055 None 20 Human Functional pAC50 = 4.6 4.6 -12 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL374478 137055 None 20 Human Functional pAC50 = 4.6 4.6 -12 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
176 398 None 47 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2157 398 None 47 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2157.0 398 None 47 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2566 398 None 47 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
CHEMBL633 398 None 47 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
DB01118 398 None 47 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2333 142422 None 66 Human Functional pAC50 = 4.5 4.5 -25 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
CHEMBL388590 142422 None 66 Human Functional pAC50 = 4.5 4.5 -25 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
118422671 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
1887 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
189562 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
189562.0 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
71301 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
71301.0 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
7246 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
9844194 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
9844194.0 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL2365658 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL3526436 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL434394 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
DB04861 2757 None 41 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
2585 803 None 59 Human Functional pAC50 = 8.5 8.5 1 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
2585.0 803 None 59 Human Functional pAC50 = 8.5 8.5 1 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 803 None 59 Human Functional pAC50 = 8.5 8.5 1 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 803 None 59 Human Functional pAC50 = 8.5 8.5 1 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 803 None 59 Human Functional pAC50 = 8.5 8.5 1 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 803 None 59 Human Functional pAC50 = 8.5 8.5 1 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
3149 12618 None 11 Human Functional pAC50 = 5.5 5.5 -8 26
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1187011 12618 None 11 Human Functional pAC50 = 5.5 5.5 -8 26
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
2601 3780 None 25 Human Functional pAC50 = 5.5 5.5 -1023 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
443951 3780 None 25 Human Functional pAC50 = 5.5 5.5 -1023 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
56 3780 None 25 Human Functional pAC50 = 5.5 5.5 -1023 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
CHEMBL73151 3780 None 25 Human Functional pAC50 = 5.5 5.5 -1023 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
DB13399 3780 None 25 Human Functional pAC50 = 5.5 5.5 -1023 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
5311064 1366 None 35 Human Functional pAC50 = 5.5 5.5 3 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 317 8 3 5 2.3 COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC 10.1038/s41467-023-40064-9
534 1366 None 35 Human Functional pAC50 = 5.5 5.5 3 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 317 8 3 5 2.3 COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC 10.1038/s41467-023-40064-9
806 1366 None 35 Human Functional pAC50 = 5.5 5.5 3 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 317 8 3 5 2.3 COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC 10.1038/s41467-023-40064-9
CHEMBL493682 1366 None 35 Human Functional pAC50 = 5.5 5.5 3 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 317 8 3 5 2.3 COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC 10.1038/s41467-023-40064-9
150 2509 None 14 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
1764 2509 None 14 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
8226 2509 None 14 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
8226.0 2509 None 14 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
CHEMBL1201356 2509 None 14 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
DB00353 2509 None 14 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
2291 3184 None 43 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
2561 3184 None 43 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
4932 3184 None 43 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
4932.0 3184 None 43 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
CHEMBL631 3184 None 43 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
DB01182 3184 None 43 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
2464 3640 None 36 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
5253 3640 None 36 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
5253.0 3640 None 36 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
7297 3640 None 36 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
CHEMBL471 3640 None 36 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
DB00489 3640 None 36 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
4567 9950 None 29 Human Functional pAC50 = 5.4 5.4 -72 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 7 3 3 3.4 CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL114655 9950 None 29 Human Functional pAC50 = 5.4 5.4 -72 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 7 3 3 3.4 CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1 10.1038/s41467-023-40064-9
2176 3127 None 40 Human Functional pAC50 = 8.4 8.4 1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
4828 3127 None 40 Human Functional pAC50 = 8.4 8.4 1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
4828.0 3127 None 40 Human Functional pAC50 = 8.4 8.4 1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
91 3127 None 40 Human Functional pAC50 = 8.4 8.4 1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL500 3127 None 40 Human Functional pAC50 = 8.4 8.4 1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
DB00960 3127 None 40 Human Functional pAC50 = 8.4 8.4 1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
44112 121354 None 36 Human Functional pAC50 = 8.3 8.3 -1 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 380 7 2 4 4.5 Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1 10.1038/s41467-023-40064-9
CHEMBL357995 121354 None 36 Human Functional pAC50 = 8.3 8.3 -1 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 380 7 2 4 4.5 Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1 10.1038/s41467-023-40064-9
9931954 10938 None 59 Human Functional pAC50 = 4.4 4.4 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 323 3 3 2 3.0 CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 10.1038/s41467-023-40064-9
CHEMBL1173055 10938 None 59 Human Functional pAC50 = 4.4 4.4 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 323 3 3 2 3.0 CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 10.1038/s41467-023-40064-9
3486 3157 None 44 Human Functional pAC50 = 5.3 5.3 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1038/s41467-023-40064-9
4883 3157 None 44 Human Functional pAC50 = 5.3 5.3 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1038/s41467-023-40064-9
555 3157 None 44 Human Functional pAC50 = 5.3 5.3 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL6995 3157 None 44 Human Functional pAC50 = 5.3 5.3 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1038/s41467-023-40064-9
DB01297 3157 None 44 Human Functional pAC50 = 5.3 5.3 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1038/s41467-023-40064-9
25382 9159 None 27 Human Functional pAC50 = 5.3 5.3 -141 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL110094 9159 None 27 Human Functional pAC50 = 5.3 5.3 -141 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
36811 1454 None 27 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
36811.0 1454 None 27 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
535 1454 None 27 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
937 1454 None 27 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
CHEMBL926 1454 None 27 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
DB00841 1454 None 27 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
16362 3125 None 49 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
16362.0 3125 None 49 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2172 3125 None 49 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
90 3125 None 49 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1423 3125 None 49 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01100 3125 None 49 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2318 154946 None 18 Human Functional pAC50 = 5.2 5.2 -8 15
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 351 7 1 3 4.1 CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL400599 154946 None 18 Human Functional pAC50 = 5.2 5.2 -8 15
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 351 7 1 3 4.1 CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1 10.1038/s41467-023-40064-9
11504295 2923 None 40 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
11504295.0 2923 None 40 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
4814 2923 None 40 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
7543 2923 None 40 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
CHEMBL605846 2923 None 40 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
DB09080 2923 None 40 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
2398 954 None 43 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2801 954 None 43 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2801.0 954 None 43 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
701 954 None 43 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL415 954 None 43 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB01242 954 None 43 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
1499 2091 None 34 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
3779 2091 None 34 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
3779.0 2091 None 34 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
536 2091 None 34 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
CHEMBL434 2091 None 34 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
DB01064 2091 None 34 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
137 370 None 37 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
2119 370 None 37 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
563 370 None 37 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
66368 370 None 37 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
CHEMBL266195 370 None 37 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
DB00866 370 None 37 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
4631 197216 None 23 Human Functional pAC50 = 8.2 8.2 -1 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 265 9 2 4 2.0 C=CCOc1ccccc1OCC(O)CNC(C)C 10.1038/s41467-023-40064-9
4631.0 197216 None 23 Human Functional pAC50 = 8.2 8.2 -1 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 265 9 2 4 2.0 C=CCOc1ccccc1OCC(O)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL546 197216 None 23 Human Functional pAC50 = 8.2 8.2 -1 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 265 9 2 4 2.0 C=CCOc1ccccc1OCC(O)CNC(C)C 10.1038/s41467-023-40064-9
DB01580 197216 None 23 Human Functional pAC50 = 8.2 8.2 -1 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 265 9 2 4 2.0 C=CCOc1ccccc1OCC(O)CNC(C)C 10.1038/s41467-023-40064-9
2169 44861 None 29 Human Functional pAC50 = 7.2 7.2 1 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 380 9 3 6 1.4 COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1 10.1038/s41467-023-40064-9
CHEMBL152231 44861 None 29 Human Functional pAC50 = 7.2 7.2 1 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 380 9 3 6 1.4 COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1 10.1038/s41467-023-40064-9
1155 1629 None 38 Human Functional pAC50 = 5.2 5.2 -7 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
3343 1629 None 38 Human Functional pAC50 = 5.2 5.2 -7 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
557 1629 None 38 Human Functional pAC50 = 5.2 5.2 -7 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
CHEMBL32800 1629 None 38 Human Functional pAC50 = 5.2 5.2 -7 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
DB01288 1629 None 38 Human Functional pAC50 = 5.2 5.2 -7 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
5329102 194838 None 50 Human Functional pAC50 = 5.2 5.2 -54 37
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 194838 None 50 Human Functional pAC50 = 5.2 5.2 -54 37
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
2249 512 None 65 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
2249.0 512 None 65 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
255 512 None 65 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
548 512 None 65 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL24 512 None 65 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
DB00335 512 None 65 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
9801 91619 None 25 Human Functional pAC50 = 5.2 5.2 -17 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 329 8 1 1 5.4 CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL24072 91619 None 25 Human Functional pAC50 = 5.2 5.2 -17 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 329 8 1 1 5.4 CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
135409453 3773 None 26 Human Functional pAC50 = 5.2 5.2 -2398 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 3773 None 26 Human Functional pAC50 = 5.2 5.2 -2398 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 3773 None 26 Human Functional pAC50 = 5.2 5.2 -2398 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
242 470 None 70 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 470 None 70 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 470 None 70 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795.0 470 None 70 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 470 None 70 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 470 None 70 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
2663 98816 None 20 Human Functional pAC50 = 7.1 7.1 60 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 9 3 5 2.9 CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1 10.1038/s41467-023-40064-9
2663.0 98816 None 20 Human Functional pAC50 = 7.1 7.1 60 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 9 3 5 2.9 CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1 10.1038/s41467-023-40064-9
CHEMBL27810 98816 None 20 Human Functional pAC50 = 7.1 7.1 60 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 9 3 5 2.9 CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1 10.1038/s41467-023-40064-9
DB04846 98816 None 20 Human Functional pAC50 = 7.1 7.1 60 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 9 3 5 2.9 CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1 10.1038/s41467-023-40064-9
2335 11852 None 18 Human Functional pAC50 = 5.1 5.1 -57 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 11852 None 18 Human Functional pAC50 = 5.1 5.1 -57 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 11852 None 18 Human Functional pAC50 = 5.1 5.1 -57 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 11852 None 18 Human Functional pAC50 = 5.1 5.1 -57 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
56959 31564 None 60 Human Functional pAC50 = 5.1 5.1 -5 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 427 9 2 6 2.3 COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1 10.1038/s41467-023-40064-9
CHEMBL1404 31564 None 60 Human Functional pAC50 = 5.1 5.1 -5 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 427 9 2 6 2.3 COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1 10.1038/s41467-023-40064-9
CHEMBL1526084 31564 None 60 Human Functional pAC50 = 5.1 5.1 -5 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 427 9 2 6 2.3 COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1 10.1038/s41467-023-40064-9
5639 98949 None 48 Human Functional pAC50 = 6.1 6.1 -15 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 387 7 1 8 0.7 COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 10.1038/s41467-023-40064-9
CHEMBL279229 98949 None 48 Human Functional pAC50 = 6.1 6.1 -15 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 387 7 1 8 0.7 COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 10.1038/s41467-023-40064-9
2351 4301 None 35 Human Functional pAC50 = 5.1 5.1 -3 22
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1008 4301 None 35 Human Functional pAC50 = 5.1 5.1 -3 22
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1257078 4301 None 35 Human Functional pAC50 = 5.1 5.1 -3 22
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
11658860 2344 None 24 Human Functional pAC50 = 5.1 5.1 -724 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
2941 2344 None 24 Human Functional pAC50 = 5.1 5.1 -724 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
4374 2344 None 24 Human Functional pAC50 = 5.1 5.1 -724 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
CHEMBL360328 2344 None 24 Human Functional pAC50 = 5.1 5.1 -724 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
DB04871 2344 None 24 Human Functional pAC50 = 5.1 5.1 -724 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
119607 208661 None 64 Human Functional pAC50 = 5.1 5.1 1 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 10.1038/s41467-023-40064-9
CHEMBL865 208661 None 64 Human Functional pAC50 = 5.1 5.1 1 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 10.1038/s41467-023-40064-9
68617 207985 None 33 Human Functional pAC50 = 5.1 5.1 -23 30
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1709 207985 None 33 Human Functional pAC50 = 5.1 5.1 -23 30
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL809 207985 None 33 Human Functional pAC50 = 5.1 5.1 -23 30
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
16363 596 None 33 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
16363.0 596 None 33 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
312 596 None 33 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
9215 596 None 33 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL297302 596 None 33 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB12867 596 None 33 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
1054 1586 None 40 Human Functional pAC50 = 6.1 6.1 66 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 295 9 2 5 1.5 COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
59768 1586 None 40 Human Functional pAC50 = 6.1 6.1 66 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 295 9 2 5 1.5 COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
7178 1586 None 40 Human Functional pAC50 = 6.1 6.1 66 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 295 9 2 5 1.5 COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
CHEMBL768 1586 None 40 Human Functional pAC50 = 6.1 6.1 66 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 295 9 2 5 1.5 COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
DB00187 1586 None 40 Human Functional pAC50 = 6.1 6.1 66 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 295 9 2 5 1.5 COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
275196 125740 None 38 Human Functional pAC50 = 5.1 5.1 -69 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
CHEMBL2106732 125740 None 38 Human Functional pAC50 = 5.1 5.1 -69 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
CHEMBL364713 125740 None 38 Human Functional pAC50 = 5.1 5.1 -69 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
156419 938 None 48 Human Functional pAC50 = 5.1 5.1 -204 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
156419.0 938 None 48 Human Functional pAC50 = 5.1 5.1 -204 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
3308 938 None 48 Human Functional pAC50 = 5.1 5.1 -204 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
647 938 None 48 Human Functional pAC50 = 5.1 5.1 -204 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL1201284 938 None 48 Human Functional pAC50 = 5.1 5.1 -204 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
DB01012 938 None 48 Human Functional pAC50 = 5.1 5.1 -204 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
41684 31229 None 62 Human Functional pAC50 = 5.1 5.1 -19 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 31229 None 62 Human Functional pAC50 = 5.1 5.1 -19 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
1673 962 None 12 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
5284371 962 None 12 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
5284371.0 962 None 12 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
725 962 None 12 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
CHEMBL485 962 None 12 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
DB00318 962 None 12 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
31101 729 None 28 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
31101.0 729 None 28 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
35 729 None 28 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
403 729 None 28 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
CHEMBL493 729 None 28 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
DB01200 729 None 28 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
135564886 14499 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
135673376 14499 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
137157436 14499 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
145948239 14499 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
71587099 14499 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
CHEMBL1201304 14499 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
1028 291 None 40 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
139148732 291 None 40 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
479 291 None 40 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
5816 291 None 40 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
5816.0 291 None 40 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
CHEMBL679 291 None 40 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
DB00668 291 None 40 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
2405 665 None 48 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
2405.0 665 None 48 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
380 665 None 48 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
7129 665 None 48 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL645 665 None 48 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
DB00612 665 None 48 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
9849126 12443 None 0 Guinea pig Functional pEC50 = 10.4 10.4 3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
CHEMBL1185969 12443 None 0 Guinea pig Functional pEC50 = 10.4 10.4 3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
CHEMBL443435 12443 None 0 Guinea pig Functional pEC50 = 10.4 10.4 3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
1499 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
3779 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
3779.0 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
536 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
CHEMBL434 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
DB01064 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
1499 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
3779 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
3779.0 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
536 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
CHEMBL434 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
DB01064 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
1499 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
3779 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
3779.0 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
536 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
CHEMBL434 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
DB01064 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
1499 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
3779 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
3779.0 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
536 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
CHEMBL434 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
DB01064 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
1499 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
3779 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
3779.0 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
536 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
CHEMBL434 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
DB01064 2091 None 34 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
11268355 96449 None 0 Human Functional pEC50 = 9.9 9.9 1 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 358 7 3 3 4.1 COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12 10.1016/s0960-894x(03)00073-8
CHEMBL26183 96449 None 0 Human Functional pEC50 = 9.9 9.9 1 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 358 7 3 3 4.1 COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12 10.1016/s0960-894x(03)00073-8
1239 1677 None 37 Guinea pig Functional pEC50 = 9.5 9.5 1 6
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
3410 1677 None 37 Guinea pig Functional pEC50 = 9.5 9.5 1 6
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
3410.0 1677 None 37 Guinea pig Functional pEC50 = 9.5 9.5 1 6
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
3465 1677 None 37 Guinea pig Functional pEC50 = 9.5 9.5 1 6
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
CHEMBL1256786 1677 None 37 Guinea pig Functional pEC50 = 9.5 9.5 1 6
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
DB00983 1677 None 37 Guinea pig Functional pEC50 = 9.5 9.5 1 6
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
24936881 17524 None 0 Human Functional pEC50 = 9.2 9.2 1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 476 8 3 8 4.1 Oc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1 10.1016/j.bmcl.2010.08.039
CHEMBL1257913 17524 None 0 Human Functional pEC50 = 9.2 9.2 1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 476 8 3 8 4.1 Oc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1 10.1016/j.bmcl.2010.08.039
12065 628 None 28 Human Functional pEC50 = 9.2 9.2 -6 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O 10.1016/j.bmcl.2009.10.013
45483813 628 None 28 Human Functional pEC50 = 9.2 9.2 -6 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O 10.1016/j.bmcl.2009.10.013
CHEMBL579394 628 None 28 Human Functional pEC50 = 9.2 9.2 -6 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O 10.1016/j.bmcl.2009.10.013
164622827 188671 None 0 Human Functional pEC50 = 9.2 9.2 -26 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868585 188671 None 0 Human Functional pEC50 = 9.2 9.2 -26 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028721 188671 None 0 Human Functional pEC50 = 9.2 9.2 -26 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
9891927 184303 None 9 Guinea pig Functional pEC50 = 9.1 9.1 -5 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL446840 184303 None 9 Guinea pig Functional pEC50 = 9.1 9.1 -5 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL483200 184303 None 9 Guinea pig Functional pEC50 = 9.1 9.1 -5 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL483201 184303 None 9 Guinea pig Functional pEC50 = 9.1 9.1 -5 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
45483810 199600 None 0 Human Functional pEC50 = 9.1 9.1 -3 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 356 6 4 5 2.4 CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL567863 199600 None 0 Human Functional pEC50 = 9.1 9.1 -3 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 356 6 4 5 2.4 CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
123686 1981 None 38 Human Functional pEC50 = 9.1 9.1 74 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 354 9 4 5 1.7 C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O 10.1021/jm400348g
12581 1981 None 38 Human Functional pEC50 = 9.1 9.1 74 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 354 9 4 5 1.7 C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O 10.1021/jm400348g
CHEMBL11268 1981 None 38 Human Functional pEC50 = 9.1 9.1 74 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 354 9 4 5 1.7 C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O 10.1021/jm400348g
1499 2091 None 34 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
3779 2091 None 34 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
3779.0 2091 None 34 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
536 2091 None 34 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
CHEMBL434 2091 None 34 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
DB01064 2091 None 34 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
164623105 188675 None 0 Human Functional pEC50 = 9.1 9.1 -47 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4862449 188675 None 0 Human Functional pEC50 = 9.1 9.1 -47 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028738 188675 None 0 Human Functional pEC50 = 9.1 9.1 -47 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
13345218 199677 None 0 Human Functional pEC50 = 9.1 9.1 -8 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 372 6 5 6 2.1 CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL568272 199677 None 0 Human Functional pEC50 = 9.1 9.1 -8 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 372 6 5 6 2.1 CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
44392175 131862 None 0 Human Functional pEC50 = 9.1 9.1 1 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 480 12 5 7 3.2 O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc([N+](=O)[O-])c1 10.1016/j.bmcl.2004.11.001
CHEMBL369346 131862 None 0 Human Functional pEC50 = 9.1 9.1 1 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 480 12 5 7 3.2 O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc([N+](=O)[O-])c1 10.1016/j.bmcl.2004.11.001
1499 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
3779 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
3779.0 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
536 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
CHEMBL434 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
DB01064 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
1499 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
3779 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
3779.0 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
536 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
CHEMBL434 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
DB01064 2091 None 34 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
1499 2091 None 34 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
3779 2091 None 34 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
3779.0 2091 None 34 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
536 2091 None 34 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
CHEMBL434 2091 None 34 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
DB01064 2091 None 34 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
44392230 65618 None 1 Human Functional pEC50 = 8.9 8.9 1 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 479 12 6 6 3.0 O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc(C(=O)O)c1 10.1016/j.bmcl.2004.11.001
CHEMBL183283 65618 None 1 Human Functional pEC50 = 8.9 8.9 1 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 479 12 6 6 3.0 O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc(C(=O)O)c1 10.1016/j.bmcl.2004.11.001
24822304 97917 None 0 Human Functional pEC50 = 8.9 8.9 6 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 412 9 3 5 4.1 O=C(O)c1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1 10.1021/jm701324c
CHEMBL272234 97917 None 0 Human Functional pEC50 = 8.9 8.9 6 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 412 9 3 5 4.1 O=C(O)c1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1 10.1021/jm701324c
105 3461 None 54 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
2083 3461 None 54 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
2083.0 3461 None 54 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
558 3461 None 54 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
CHEMBL714 3461 None 54 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
DB01001 3461 None 54 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
164615126 188611 None 0 Human Functional pEC50 = 8.8 8.8 -104 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4854569 188611 None 0 Human Functional pEC50 = 8.8 8.8 -104 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028293 188611 None 0 Human Functional pEC50 = 8.8 8.8 -104 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
90645347 112576 None 0 Human Functional pEC50 = 8.8 8.8 -7 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 578 12 6 7 5.6 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298987 112576 None 0 Human Functional pEC50 = 8.8 8.8 -7 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 578 12 6 7 5.6 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.095
164618895 188642 None 0 Human Functional pEC50 = 8.8 8.8 -95 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868938 188642 None 0 Human Functional pEC50 = 8.8 8.8 -95 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028525 188642 None 0 Human Functional pEC50 = 8.8 8.8 -95 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
45101519 200979 None 0 Human Functional pEC50 = 8.7 8.7 -1 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 498 11 8 7 1.6 CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL577917 200979 None 0 Human Functional pEC50 = 8.7 8.7 -1 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 498 11 8 7 1.6 CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
24936492 17556 None 0 Human Functional pEC50 = 8.7 8.7 -1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 482 8 3 9 4.1 Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5cccs5)c34)CC2)cc1 10.1016/j.bmcl.2010.08.039
CHEMBL1258026 17556 None 0 Human Functional pEC50 = 8.7 8.7 -1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 482 8 3 9 4.1 Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5cccs5)c34)CC2)cc1 10.1016/j.bmcl.2010.08.039
164612078 188585 None 0 Human Functional pEC50 = 8.7 8.7 -64 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4848617 188585 None 0 Human Functional pEC50 = 8.7 8.7 -64 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028119 188585 None 0 Human Functional pEC50 = 8.7 8.7 -64 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
9927453 96740 None 0 Human Functional pEC50 = 8.7 8.7 -1 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 328 6 3 2 4.1 C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
CHEMBL26393 96740 None 0 Human Functional pEC50 = 8.7 8.7 -1 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 328 6 3 2 4.1 C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
42625513 12563 None 0 Guinea pig Functional pEC50 = 8.7 8.7 -3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm801016j
CHEMBL1186722 12563 None 0 Guinea pig Functional pEC50 = 8.7 8.7 -3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm801016j
CHEMBL475389 12563 None 0 Guinea pig Functional pEC50 = 8.7 8.7 -3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm801016j
90645346 112558 None 0 Human Functional pEC50 = 8.7 8.7 -2 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 578 13 6 7 4.7 O=C(NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1)c1ccccc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298762 112558 None 0 Human Functional pEC50 = 8.7 8.7 -2 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 578 13 6 7 4.7 O=C(NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1)c1ccccc1 10.1016/j.bmcl.2014.04.095
42625517 12725 None 0 Guinea pig Functional pEC50 = 8 8.0 -19 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 536 19 5 7 3.8 CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1187654 12725 None 0 Guinea pig Functional pEC50 = 8 8.0 -19 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 536 19 5 7 3.8 CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL514032 12725 None 0 Guinea pig Functional pEC50 = 8 8.0 -19 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 536 19 5 7 3.8 CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
11180293 112571 None 0 Human Functional pEC50 = 8 8.0 -22 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 543 12 6 8 3.1 O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2014.04.095
CHEMBL3298897 112571 None 0 Human Functional pEC50 = 8 8.0 -22 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 543 12 6 8 3.1 O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2014.04.095
56668796 66623 None 0 Human Functional pEC50 = 8 8.0 -31 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 598 20 7 7 4.3 O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1 10.1016/j.bmc.2011.08.043
CHEMBL1835860 66623 None 0 Human Functional pEC50 = 8 8.0 -31 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 598 20 7 7 4.3 O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1 10.1016/j.bmc.2011.08.043
CHEMBL1852632 66623 None 0 Human Functional pEC50 = 8 8.0 -31 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 598 20 7 7 4.3 O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1 10.1016/j.bmc.2011.08.043
45273268 198085 None 0 Human Functional pEC50 = 8 8.0 194 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 362 10 3 4 4.0 O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1204004 198085 None 0 Human Functional pEC50 = 8 8.0 194 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 362 10 3 4 4.0 O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL556274 198085 None 0 Human Functional pEC50 = 8 8.0 194 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 362 10 3 4 4.0 O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
10217757 112333 None 0 Human Functional pEC50 = 8 8.0 -31 4
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 497 12 5 6 5.2 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.069
CHEMBL3290998 112333 None 0 Human Functional pEC50 = 8 8.0 -31 4
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 497 12 5 6 5.2 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.069
164614147 188599 None 0 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4856990 188599 None 0 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028233 188599 None 0 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164618813 188641 None 0 Human Functional pEC50 = 8.0 8.0 -275 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4865833 188641 None 0 Human Functional pEC50 = 8.0 8.0 -275 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028523 188641 None 0 Human Functional pEC50 = 8.0 8.0 -275 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
164619360 188645 None 0 Human Functional pEC50 = 8.0 8.0 -371 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868763 188645 None 0 Human Functional pEC50 = 8.0 8.0 -371 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028547 188645 None 0 Human Functional pEC50 = 8.0 8.0 -371 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
1155 1629 None 38 Human Functional pEC50 = 8.0 8.0 -7 11
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1016/j.ejmech.2022.114961
3343 1629 None 38 Human Functional pEC50 = 8.0 8.0 -7 11
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1016/j.ejmech.2022.114961
557 1629 None 38 Human Functional pEC50 = 8.0 8.0 -7 11
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1016/j.ejmech.2022.114961
CHEMBL32800 1629 None 38 Human Functional pEC50 = 8.0 8.0 -7 11
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1016/j.ejmech.2022.114961
DB01288 1629 None 38 Human Functional pEC50 = 8.0 8.0 -7 11
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1016/j.ejmech.2022.114961
155774 4096 None 34 Human Functional pEC50 = 8.0 8.0 38 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
2848 4096 None 34 Human Functional pEC50 = 8.0 8.0 38 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
538 4096 None 34 Human Functional pEC50 = 8.0 8.0 38 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
CHEMBL75753 4096 None 34 Human Functional pEC50 = 8.0 8.0 38 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
DB13781 4096 None 34 Human Functional pEC50 = 8.0 8.0 38 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
10863093 50341 None 0 Human Functional pEC50 = 7 7.0 -19 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 439 10 4 6 2.1 C[C@H](CNc1ccc(CC(=O)NS(C)(=O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
CHEMBL157210 50341 None 0 Human Functional pEC50 = 7 7.0 -19 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 439 10 4 6 2.1 C[C@H](CNc1ccc(CC(=O)NS(C)(=O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
16049450 64114 None 0 Human Functional pEC50 = 7 7.0 -125 2
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 481 13 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807827 64114 None 0 Human Functional pEC50 = 7 7.0 -125 2
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 481 13 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
16049234 64115 None 0 Human Functional pEC50 = 7 7.0 -177 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 481 13 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3ccccc3Cl)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807828 64115 None 0 Human Functional pEC50 = 7 7.0 -177 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 481 13 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3ccccc3Cl)c2s1 10.1016/j.bmcl.2011.05.097
16049448 64116 None 0 Human Functional pEC50 = 7 7.0 -56 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 515 13 5 7 4.2 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3Cl)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807829 64116 None 0 Human Functional pEC50 = 7 7.0 -56 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 515 13 5 7 4.2 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3Cl)c2s1 10.1016/j.bmcl.2011.05.097
16049374 64120 None 0 Human Functional pEC50 = 7 7.0 -89 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 481 13 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807869 64120 None 0 Human Functional pEC50 = 7 7.0 -89 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 481 13 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
1499 2091 None 34 Human Functional pEC50 = 7 7.0 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.03.044
3779 2091 None 34 Human Functional pEC50 = 7 7.0 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.03.044
3779.0 2091 None 34 Human Functional pEC50 = 7 7.0 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.03.044
536 2091 None 34 Human Functional pEC50 = 7 7.0 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.03.044
CHEMBL434 2091 None 34 Human Functional pEC50 = 7 7.0 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.03.044
DB01064 2091 None 34 Human Functional pEC50 = 7 7.0 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.03.044
9888047 93434 None 0 Human Functional pEC50 = 7 7.0 -398 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 414 9 4 5 4.4 C[C@H](CNc1cccc(-c2occc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL245673 93434 None 0 Human Functional pEC50 = 7 7.0 -398 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 414 9 4 5 4.4 C[C@H](CNc1cccc(-c2occc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
44441231 148142 None 0 Human Functional pEC50 = 7 7.0 -50 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 431 9 4 6 4.3 C[C@H](CNc1cccc(-c2csc(C(=O)O)n2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL393470 148142 None 0 Human Functional pEC50 = 7 7.0 -50 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 431 9 4 6 4.3 C[C@H](CNc1cccc(-c2csc(C(=O)O)n2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
44441235 151081 None 0 Human Functional pEC50 = 7 7.0 -251 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 430 9 4 5 4.9 C[C@H](CNc1ccc(-c2sccc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL395834 151081 None 0 Human Functional pEC50 = 7 7.0 -251 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 430 9 4 5 4.9 C[C@H](CNc1ccc(-c2sccc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
45271523 197584 None 0 Human Functional pEC50 = 7 7.0 -10 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 435 10 4 4 4.4 Cc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1204000 197584 None 0 Human Functional pEC50 = 7 7.0 -10 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 435 10 4 4 4.4 Cc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL550096 197584 None 0 Human Functional pEC50 = 7 7.0 -10 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 435 10 4 4 4.4 Cc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
45272417 197897 None 0 Human Functional pEC50 = 7 7.0 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 455 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2cccc(Cl)c2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL2448074 197897 None 0 Human Functional pEC50 = 7 7.0 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 455 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2cccc(Cl)c2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL552368 197897 None 0 Human Functional pEC50 = 7 7.0 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 455 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2cccc(Cl)c2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
42625823 12683 None 0 Human Functional pEC50 = 7 7.0 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 576 19 5 7 4.7 O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1187371 12683 None 0 Human Functional pEC50 = 7 7.0 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 576 19 5 7 4.7 O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL500782 12683 None 0 Human Functional pEC50 = 7 7.0 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 576 19 5 7 4.7 O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
46832804 6988 None 0 Human Functional pEC50 = 7 7.0 -50 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 496 17 5 8 1.9 NS(=O)(=O)c1ccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm100326d
CHEMBL1084655 6988 None 0 Human Functional pEC50 = 7 7.0 -50 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 496 17 5 8 1.9 NS(=O)(=O)c1ccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm100326d
10553603 99752 None 0 Human Functional pEC50 = 7 7.0 1 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 506 10 6 8 1.5 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(NC(=O)CC(=O)O)cc3)CC2)ccc1O 10.1021/jm000544b
CHEMBL284612 99752 None 0 Human Functional pEC50 = 7 7.0 1 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 506 10 6 8 1.5 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(NC(=O)CC(=O)O)cc3)CC2)ccc1O 10.1021/jm000544b
42625517 12725 None 0 Human Functional pEC50 = 6 6.0 -1995 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 536 19 5 7 3.8 CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1187654 12725 None 0 Human Functional pEC50 = 6 6.0 -1995 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 536 19 5 7 3.8 CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL514032 12725 None 0 Human Functional pEC50 = 6 6.0 -1995 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 536 19 5 7 3.8 CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
42625588 180532 None 0 Human Functional pEC50 = 6 6.0 -630 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 508 18 5 7 2.9 NS(=O)(=O)Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL475237 180532 None 0 Human Functional pEC50 = 6 6.0 -630 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 508 18 5 7 2.9 NS(=O)(=O)Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
10121328 4439 None 0 Human Functional pEC50 = 6 6.0 -100 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 593 11 5 10 1.4 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4cc(C(=O)O)cn4)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
CHEMBL101606 4439 None 0 Human Functional pEC50 = 6 6.0 -100 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 593 11 5 10 1.4 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4cc(C(=O)O)cn4)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
11575154 77244 None 0 Human Functional pEC50 = 5 5.0 -100000 2
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 411 9 4 5 3.8 O=C(O)c1ccncc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1 10.1021/jm0509445
CHEMBL207943 77244 None 0 Human Functional pEC50 = 5 5.0 -100000 2
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 411 9 4 5 3.8 O=C(O)c1ccncc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1 10.1021/jm0509445
44237766 58256 None 0 Rat Functional pEC50 = 5 5.0 -10000 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 550 10 6 6 5.5 O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)Nc1cccc(Oc2ccccc2)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682221 58256 None 0 Rat Functional pEC50 = 5 5.0 -10000 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 550 10 6 6 5.5 O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)Nc1cccc(Oc2ccccc2)c1 10.1016/j.bmcl.2010.12.096
155517986 170310 None 0 Human Functional pEC50 = 5 5.0 -478630 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 366 7 4 4 3.3 CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4445289 170310 None 0 Human Functional pEC50 = 5 5.0 -478630 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 366 7 4 4 3.3 CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
164622775 188670 None 0 Human Functional pEC50 = 5 5.0 -120226 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 428 10 4 7 2.5 COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
CHEMBL4867311 188670 None 0 Human Functional pEC50 = 5 5.0 -120226 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 428 10 4 7 2.5 COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
CHEMBL5028718 188670 None 0 Human Functional pEC50 = 5 5.0 -120226 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 428 10 4 7 2.5 COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
44313150 103832 None 0 Human Functional pEC50 = 5 5.0 -6 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)c2)cc1 10.1016/s0960-894x(00)00459-5
CHEMBL308868 103832 None 0 Human Functional pEC50 = 5 5.0 -6 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)c2)cc1 10.1016/s0960-894x(00)00459-5
1960 2857 None 46 Guinea pig Functional pEC50 = 5 5.0 -37 18
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
439260 2857 None 46 Guinea pig Functional pEC50 = 5 5.0 -37 18
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
439260.0 2857 None 46 Guinea pig Functional pEC50 = 5 5.0 -37 18
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
505 2857 None 46 Guinea pig Functional pEC50 = 5 5.0 -37 18
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
CHEMBL1437 2857 None 46 Guinea pig Functional pEC50 = 5 5.0 -37 18
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
DB00368 2857 None 46 Guinea pig Functional pEC50 = 5 5.0 -37 18
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
10301101 103015 None 0 Human Functional pEC50 = 4 4.0 -1659 2
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
ChEMBL 509 9 3 6 3.5 COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3cccc4[nH]c5ccccc5c34)CC2)cc1 10.1016/s0960-894x(03)00387-1
CHEMBL306423 103015 None 0 Human Functional pEC50 = 4 4.0 -1659 2
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
ChEMBL 509 9 3 6 3.5 COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3cccc4[nH]c5ccccc5c34)CC2)cc1 10.1016/s0960-894x(03)00387-1
145984792 165824 None 0 Human Functional pEC50 = 4 4.0 -12882 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 461 12 4 5 3.1 CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)c3ccccc3)cc2)c1 10.1016/j.ejmech.2018.03.032
CHEMBL4246134 165824 None 0 Human Functional pEC50 = 4 4.0 -12882 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 461 12 4 5 3.1 CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)c3ccccc3)cc2)c1 10.1016/j.ejmech.2018.03.032
45483848 199596 None 0 Human Functional pEC50 = 6 6.0 - 1
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 394 7 3 3 5.3 CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1 10.1016/j.bmcl.2009.10.013
CHEMBL567843 199596 None 0 Human Functional pEC50 = 6 6.0 - 1
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 394 7 3 3 5.3 CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1 10.1016/j.bmcl.2009.10.013
11567751 203215 None 0 Human Functional pEC50 = 7 7.0 -29 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 374 6 4 5 2.5 CC(C)(Cc1ccc(F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL600401 203215 None 0 Human Functional pEC50 = 7 7.0 -29 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 374 6 4 5 2.5 CC(C)(Cc1ccc(F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
10145482 4170 None 0 Human Functional pEC50 = 6 6.0 -34 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 604 12 5 7 3.4 O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
CHEMBL100057 4170 None 0 Human Functional pEC50 = 6 6.0 -34 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 604 12 5 7 3.4 O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
10281165 4414 None 0 Human Functional pEC50 = 6.0 6.0 -16 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 560 11 5 7 3.3 O=C(Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1)NC1CCCCC1 10.1016/s0960-894x(02)00607-8
CHEMBL101485 4414 None 0 Human Functional pEC50 = 6.0 6.0 -16 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 560 11 5 7 3.3 O=C(Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1)NC1CCCCC1 10.1016/s0960-894x(02)00607-8
11539348 203243 None 0 Human Functional pEC50 = 7.0 7.0 -9 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 434 6 4 5 3.1 CC(C)(Cc1ccc(Br)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL600616 203243 None 0 Human Functional pEC50 = 7.0 7.0 -9 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 434 6 4 5 3.1 CC(C)(Cc1ccc(Br)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
44309649 206750 None 0 Human Functional pEC50 = 5.0 5.0 -186 2
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
ChEMBL 436 9 3 7 1.6 COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(03)00387-1
CHEMBL71348 206750 None 0 Human Functional pEC50 = 5.0 5.0 -186 2
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
ChEMBL 436 9 3 7 1.6 COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(03)00387-1
3083544 26817 None 34 Human Functional pEC50 = 7.0 7.0 -199 6
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/acs.jmedchem.0c01195
3083544.0 26817 None 34 Human Functional pEC50 = 7.0 7.0 -199 6
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/acs.jmedchem.0c01195
CHEMBL1200811 26817 None 34 Human Functional pEC50 = 7.0 7.0 -199 6
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/acs.jmedchem.0c01195
CHEMBL1363 26817 None 34 Human Functional pEC50 = 7.0 7.0 -199 6
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/acs.jmedchem.0c01195
CHEMBL1951071 26817 None 34 Human Functional pEC50 = 7.0 7.0 -199 6
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/acs.jmedchem.0c01195
CHEMBL605993 26817 None 34 Human Functional pEC50 = 7.0 7.0 -199 6
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/acs.jmedchem.0c01195
DB00983 26817 None 34 Human Functional pEC50 = 7.0 7.0 -199 6
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/acs.jmedchem.0c01195
DB01274 26817 None 34 Human Functional pEC50 = 7.0 7.0 -199 6
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/acs.jmedchem.0c01195
10280301 109793 None 0 Human Functional pEC50 = 7.0 7.0 -2 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 536 12 5 6 3.9 O=C(NCc1ccc(F)cc1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL322973 109793 None 0 Human Functional pEC50 = 7.0 7.0 -2 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 536 12 5 6 3.9 O=C(NCc1ccc(F)cc1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
10231394 167919 None 0 Human Functional pEC50 = 5.0 5.0 -190 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 562 15 5 7 3.5 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
CHEMBL430662 167919 None 0 Human Functional pEC50 = 5.0 5.0 -190 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 562 15 5 7 3.5 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
24823782 98098 None 0 Human Functional pEC50 = 8.0 8.0 3 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 396 8 3 4 4.0 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1 10.1021/jm701324c
CHEMBL273097 98098 None 0 Human Functional pEC50 = 8.0 8.0 3 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 396 8 3 4 4.0 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1 10.1021/jm701324c
45484646 199750 None 0 Human Functional pEC50 = 8.0 8.0 -1 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 456 10 6 7 2.0 CC(C)(Cc1ccc(NC(=O)CCCN)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL568667 199750 None 0 Human Functional pEC50 = 8.0 8.0 -1 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 456 10 6 7 2.0 CC(C)(Cc1ccc(NC(=O)CCCN)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
24894323 176563 None 0 Human Functional pEC50 = 8.0 8.0 -52 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 468 12 4 5 5.2 CCCOc1cc(-c2ccc(NCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL459645 176563 None 0 Human Functional pEC50 = 8.0 8.0 -52 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 468 12 4 5 5.2 CCCOc1cc(-c2ccc(NCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
155536813 172309 None 0 Human Functional pEC50 = 8.0 8.0 -263 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4473790 172309 None 0 Human Functional pEC50 = 8.0 8.0 -263 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
45270680 197285 None 0 Human Functional pEC50 = 7.0 7.0 5 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 421 10 4 4 4.1 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1203993 197285 None 0 Human Functional pEC50 = 7.0 7.0 5 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 421 10 4 4 4.1 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL549421 197285 None 0 Human Functional pEC50 = 7.0 7.0 5 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 421 10 4 4 4.1 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
45269853 199024 None 0 Human Functional pEC50 = 7.0 7.0 -4 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 426 11 3 5 3.1 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL563872 199024 None 0 Human Functional pEC50 = 7.0 7.0 -4 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 426 11 3 5 3.1 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
52943968 17801 None 0 Human Functional pEC50 = 7.0 7.0 1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 518 9 4 8 3.8 NC(=O)Nc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1 10.1016/j.bmcl.2010.08.039
CHEMBL1258824 17801 None 0 Human Functional pEC50 = 7.0 7.0 1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 518 9 4 8 3.8 NC(=O)Nc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1 10.1016/j.bmcl.2010.08.039
16222840 198187 None 0 Human Functional pEC50 = 7.0 7.0 -316 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
ChEMBL 566 11 4 7 4.7 C[C@H](NCCc1ccc(-c2ccc(C(=O)NS(C)(=O)=O)c(OC3CCCCC3)c2)cc1)[C@H](O)c1ccc(O)cc1 10.1016/j.bmcl.2009.06.083
CHEMBL557253 198187 None 0 Human Functional pEC50 = 7.0 7.0 -316 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
ChEMBL 566 11 4 7 4.7 C[C@H](NCCc1ccc(-c2ccc(C(=O)NS(C)(=O)=O)c(OC3CCCCC3)c2)cc1)[C@H](O)c1ccc(O)cc1 10.1016/j.bmcl.2009.06.083
24895559 173204 None 0 Human Functional pEC50 = 7.0 7.0 -338 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 483 12 3 5 5.4 CC(C)COc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL452034 173204 None 0 Human Functional pEC50 = 7.0 7.0 -338 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 483 12 3 5 5.4 CC(C)COc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
105 3461 None 54 Human Functional pEC50 = 5.9 5.9 -28 3
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.0c01195
2083 3461 None 54 Human Functional pEC50 = 5.9 5.9 -28 3
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.0c01195
2083.0 3461 None 54 Human Functional pEC50 = 5.9 5.9 -28 3
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.0c01195
558 3461 None 54 Human Functional pEC50 = 5.9 5.9 -28 3
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.0c01195
CHEMBL714 3461 None 54 Human Functional pEC50 = 5.9 5.9 -28 3
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.0c01195
DB01001 3461 None 54 Human Functional pEC50 = 5.9 5.9 -28 3
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.0c01195
44377726 56834 None 0 Human Functional pEC50 = 5.9 5.9 -389 2
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 550 10 5 10 1.6 CS(=O)(=O)Nc1cc(O[C@@H](O)CNC2CCN(c3ccc(CC4SC(=O)NC4=O)cc3)CC2)ccc1O 10.1016/s0960-894x(01)00063-4
CHEMBL164378 56834 None 0 Human Functional pEC50 = 5.9 5.9 -389 2
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 550 10 5 10 1.6 CS(=O)(=O)Nc1cc(O[C@@H](O)CNC2CCN(c3ccc(CC4SC(=O)NC4=O)cc3)CC2)ccc1O 10.1016/s0960-894x(01)00063-4
1499 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.06.031
3779 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.06.031
3779.0 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.06.031
536 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.06.031
CHEMBL434 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.06.031
DB01064 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2009.06.031
1499 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2009.01.022
3779 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2009.01.022
3779.0 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2009.01.022
536 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2009.01.022
CHEMBL434 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2009.01.022
DB01064 2091 None 34 Human Functional pEC50 = 7.9 7.9 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2009.01.022
16223251 176564 None 0 Human Functional pEC50 = 7.9 7.9 -204 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 449 11 4 6 3.9 CC(C)Cc1cc(-c2ccc(OCCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL459646 176564 None 0 Human Functional pEC50 = 7.9 7.9 -204 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 449 11 4 6 3.9 CC(C)Cc1cc(-c2ccc(OCCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O 10.1021/jm8000345
24895787 186800 None 0 Human Functional pEC50 = 7.9 7.9 -1 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 409 8 3 3 5.0 C[C@@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm8000345
CHEMBL488431 186800 None 0 Human Functional pEC50 = 7.9 7.9 -1 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 409 8 3 3 5.0 C[C@@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm8000345
44309272 206336 None 0 Human Functional pEC50 = 7.9 7.9 -2 3
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
ChEMBL 611 14 6 8 2.9 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1 10.1016/s0960-894x(03)00387-1
CHEMBL68766 206336 None 0 Human Functional pEC50 = 7.9 7.9 -2 3
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
ChEMBL 611 14 6 8 2.9 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1 10.1016/s0960-894x(03)00387-1
44392181 66092 None 0 Human Functional pEC50 = 7.9 7.9 -10 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 465 12 5 6 3.3 COc1ccccc1NC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
CHEMBL183744 66092 None 0 Human Functional pEC50 = 7.9 7.9 -10 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 465 12 5 6 3.3 COc1ccccc1NC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
44441230 93840 None 0 Human Functional pEC50 = 7.9 7.9 -7 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 431 9 4 6 4.3 C[C@H](CNc1ccc(-c2csc(C(=O)O)n2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL247518 93840 None 0 Human Functional pEC50 = 7.9 7.9 -7 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 431 9 4 6 4.3 C[C@H](CNc1ccc(-c2csc(C(=O)O)n2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
2687 889 None 12 Human Functional pEC50 = 7.9 7.9 -6 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 279 5 4 4 1.0 OC(COc1cccc2c1[nH]c(=O)[nH]2)CNC(C)(C)C 10.1021/jm400348g
532 889 None 12 Human Functional pEC50 = 7.9 7.9 -6 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 279 5 4 4 1.0 OC(COc1cccc2c1[nH]c(=O)[nH]2)CNC(C)(C)C 10.1021/jm400348g
5387 889 None 12 Human Functional pEC50 = 7.9 7.9 -6 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 279 5 4 4 1.0 OC(COc1cccc2c1[nH]c(=O)[nH]2)CNC(C)(C)C 10.1021/jm400348g
CHEMBL420746 889 None 12 Human Functional pEC50 = 7.9 7.9 -6 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 279 5 4 4 1.0 OC(COc1cccc2c1[nH]c(=O)[nH]2)CNC(C)(C)C 10.1021/jm400348g
44441226 93721 None 0 Human Functional pEC50 = 7.9 7.9 1 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 9 4 6 3.8 C[C@H](CNc1ccc(-c2nc(C(=O)O)co2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL246908 93721 None 0 Human Functional pEC50 = 7.9 7.9 1 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 9 4 6 3.8 C[C@H](CNc1ccc(-c2nc(C(=O)O)co2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
1239 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
3410 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
3410.0 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
3465 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
CHEMBL1256786 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
DB00983 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
90645345 112542 None 0 Human Functional pEC50 = 7.9 7.9 -11 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 574 12 6 8 4.7 CC(C)(C)OC(=O)NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298692 112542 None 0 Human Functional pEC50 = 7.9 7.9 -11 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 574 12 6 8 4.7 CC(C)(C)OC(=O)NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
56943485 112566 None 0 Human Functional pEC50 = 7.9 7.9 -12 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 544 12 5 8 3.6 O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCOCC5)cc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2014.04.095
CHEMBL3298831 112566 None 0 Human Functional pEC50 = 7.9 7.9 -12 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 544 12 5 8 3.6 O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCOCC5)cc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2014.04.095
46832798 14208 None 0 Human Functional pEC50 = 7.9 7.9 -31 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 485 16 4 6 4.6 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cc(Cl)ccc2Cl)ccc1O 10.1021/jm100326d
CHEMBL1084648 14208 None 0 Human Functional pEC50 = 7.9 7.9 -31 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 485 16 4 6 4.6 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cc(Cl)ccc2Cl)ccc1O 10.1021/jm100326d
CHEMBL1198879 14208 None 0 Human Functional pEC50 = 7.9 7.9 -31 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 485 16 4 6 4.6 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cc(Cl)ccc2Cl)ccc1O 10.1021/jm100326d
46832509 14217 None 0 Human Functional pEC50 = 7.9 7.9 -50 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 510 18 5 8 2.7 CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL1085399 14217 None 0 Human Functional pEC50 = 7.9 7.9 -50 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 510 18 5 8 2.7 CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL1198908 14217 None 0 Human Functional pEC50 = 7.9 7.9 -50 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 510 18 5 8 2.7 CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
46832232 14220 None 0 Human Functional pEC50 = 7.9 7.9 -100 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 467 16 4 6 4.5 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O 10.1021/jm100326d
CHEMBL1085837 14220 None 0 Human Functional pEC50 = 7.9 7.9 -100 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 467 16 4 6 4.5 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O 10.1021/jm100326d
CHEMBL1198923 14220 None 0 Human Functional pEC50 = 7.9 7.9 -100 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 467 16 4 6 4.5 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O 10.1021/jm100326d
1239 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
3410 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
3410.0 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
3465 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
CHEMBL1256786 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
DB00983 1677 None 37 Human Functional pEC50 = 7.9 7.9 -67 6
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
24895557 173203 None 0 Human Functional pEC50 = 6.9 6.9 -575 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 469 12 3 5 5.2 CCCOc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL452033 173203 None 0 Human Functional pEC50 = 6.9 6.9 -575 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 469 12 3 5 5.2 CCCOc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
44392490 65264 None 0 Human Functional pEC50 = 6.9 6.9 -1 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 507 10 4 6 4.0 C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NC(=O)c2ccccc2)c1 10.1016/j.bmcl.2004.12.033
CHEMBL182708 65264 None 0 Human Functional pEC50 = 6.9 6.9 -1 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 507 10 4 6 4.0 C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NC(=O)c2ccccc2)c1 10.1016/j.bmcl.2004.12.033
44268327 98352 None 0 Human Functional pEC50 = 5.9 5.9 -1 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 448 11 4 6 3.0 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C1CCCCC1 10.1016/s0960-894x(98)00169-3
CHEMBL274807 98352 None 0 Human Functional pEC50 = 5.9 5.9 -1 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 448 11 4 6 3.0 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C1CCCCC1 10.1016/s0960-894x(98)00169-3
10575455 100032 None 1 Human Functional pEC50 = 5.9 5.9 -60 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 448 8 5 7 1.2 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(N)=O)cc3)CC2)ccc1O 10.1021/jm000544b
CHEMBL286574 100032 None 1 Human Functional pEC50 = 5.9 5.9 -60 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 448 8 5 7 1.2 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(N)=O)cc3)CC2)ccc1O 10.1021/jm000544b
11504295 2923 None 40 Human Functional pEC50 = 6.9 6.9 -954 8
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
11504295.0 2923 None 40 Human Functional pEC50 = 6.9 6.9 -954 8
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
4814 2923 None 40 Human Functional pEC50 = 6.9 6.9 -954 8
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
7543 2923 None 40 Human Functional pEC50 = 6.9 6.9 -954 8
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
CHEMBL605846 2923 None 40 Human Functional pEC50 = 6.9 6.9 -954 8
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
DB09080 2923 None 40 Human Functional pEC50 = 6.9 6.9 -954 8
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
145982668 166009 None 0 Human Functional pEC50 = 6.9 6.9 -15 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 418 11 3 4 4.1 CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=O)c2ccccc2)cc1 10.1016/j.ejmech.2018.03.032
CHEMBL4250215 166009 None 0 Human Functional pEC50 = 6.9 6.9 -15 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 418 11 3 4 4.1 CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=O)c2ccccc2)cc1 10.1016/j.ejmech.2018.03.032
2419 3463 None 53 Human Functional pEC50 = 5.9 5.9 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
5152 3463 None 53 Human Functional pEC50 = 5.9 5.9 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
5152.0 3463 None 53 Human Functional pEC50 = 5.9 5.9 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
559 3463 None 53 Human Functional pEC50 = 5.9 5.9 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
CHEMBL1263 3463 None 53 Human Functional pEC50 = 5.9 5.9 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
DB00938 3463 None 53 Human Functional pEC50 = 5.9 5.9 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
53357711 64519 None 0 Human Functional pEC50 = 6.9 6.9 -125 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 531 19 7 7 3.3 O=C(O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
CHEMBL1814279 64519 None 0 Human Functional pEC50 = 6.9 6.9 -125 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 531 19 7 7 3.3 O=C(O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
CHEMBL1814280 64519 None 0 Human Functional pEC50 = 6.9 6.9 -125 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 531 19 7 7 3.3 O=C(O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
56675511 66430 None 0 Human Functional pEC50 = 6.9 6.9 -100 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 527 18 5 7 3.2 O=C1CNC(=O)N1Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
CHEMBL1814273 66430 None 0 Human Functional pEC50 = 6.9 6.9 -100 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 527 18 5 7 3.2 O=C1CNC(=O)N1Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
CHEMBL1851850 66430 None 0 Human Functional pEC50 = 6.9 6.9 -100 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 527 18 5 7 3.2 O=C1CNC(=O)N1Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
42625587 12704 None 0 Human Functional pEC50 = 6.9 6.9 -125 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 562 18 4 7 4.3 O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCCCC1 10.1021/jm801016j
CHEMBL1187520 12704 None 0 Human Functional pEC50 = 6.9 6.9 -125 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 562 18 4 7 4.3 O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCCCC1 10.1021/jm801016j
CHEMBL506518 12704 None 0 Human Functional pEC50 = 6.9 6.9 -125 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 562 18 4 7 4.3 O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCCCC1 10.1021/jm801016j
9845280 77356 None 0 Human Functional pEC50 = 5.9 5.9 -7 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 424 9 3 5 4.5 COC(=O)c1cccc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)c1 10.1021/jm0509445
CHEMBL208352 77356 None 0 Human Functional pEC50 = 5.9 5.9 -7 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 424 9 3 5 4.5 COC(=O)c1cccc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)c1 10.1021/jm0509445
23661589 93474 None 0 Human Functional pEC50 = 5.9 5.9 -19952 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 430 9 4 5 4.9 C[C@H](CNc1cccc(-c2sccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL245873 93474 None 0 Human Functional pEC50 = 5.9 5.9 -19952 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 430 9 4 5 4.9 C[C@H](CNc1cccc(-c2sccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
42625741 12603 None 0 Human Functional pEC50 = 5.9 5.9 -158 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCCOCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1186940 12603 None 0 Human Functional pEC50 = 5.9 5.9 -158 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCCOCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL483202 12603 None 0 Human Functional pEC50 = 5.9 5.9 -158 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCCOCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
42625898 185361 None 0 Human Functional pEC50 = 5.9 5.9 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 591 17 7 9 1.5 NS(=O)(=O)O.NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL485847 185361 None 0 Human Functional pEC50 = 5.9 5.9 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 591 17 7 9 1.5 NS(=O)(=O)O.NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
145983711 165478 None 0 Human Functional pEC50 = 4.9 4.9 -2691 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 476 12 5 5 3.5 CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)Nc3ccccc3)cc2)c1 10.1016/j.ejmech.2018.03.032
CHEMBL4237802 165478 None 0 Human Functional pEC50 = 4.9 4.9 -2691 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 476 12 5 5 3.5 CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)Nc3ccccc3)cc2)c1 10.1016/j.ejmech.2018.03.032
24895265 186799 None 0 Human Functional pEC50 = 7.9 7.9 -70 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 409 8 3 3 5.0 C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm8000345
CHEMBL488430 186799 None 0 Human Functional pEC50 = 7.9 7.9 -70 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 409 8 3 3 5.0 C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm8000345
44392552 64547 None 0 Human Functional pEC50 = 7.9 7.9 -23 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 543 11 4 7 3.6 C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2ccccc2)c1 10.1016/j.bmcl.2004.12.033
CHEMBL181440 64547 None 0 Human Functional pEC50 = 7.9 7.9 -23 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 543 11 4 7 3.6 C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2ccccc2)c1 10.1016/j.bmcl.2004.12.033
155564340 175528 None 0 Human Functional pEC50 = 7.9 7.9 -263 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 493 11 5 5 4.9 CC(CC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)CC(C)(C)C 10.1016/j.bmc.2018.10.043
CHEMBL4576089 175528 None 0 Human Functional pEC50 = 7.9 7.9 -263 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 493 11 5 5 4.9 CC(CC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)CC(C)(C)C 10.1016/j.bmc.2018.10.043
44574826 178705 None 0 Human Functional pEC50 = 6.9 6.9 2 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 484 13 3 6 3.7 O=C(Cc1cn(Cc2ccccc2)cn1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL467301 178705 None 0 Human Functional pEC50 = 6.9 6.9 2 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 484 13 3 6 3.7 O=C(Cc1cn(Cc2ccccc2)cn1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
45270697 197626 None 0 Human Functional pEC50 = 6.9 6.9 -20 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 451 11 4 5 4.1 COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1203995 197626 None 0 Human Functional pEC50 = 6.9 6.9 -20 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 451 11 4 5 4.1 COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL550444 197626 None 0 Human Functional pEC50 = 6.9 6.9 -20 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 451 11 4 5 4.1 COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
44580039 187056 None 0 Human Functional pEC50 = 6.9 6.9 -15 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 530 11 4 5 5.9 O=C(Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O)c1ccccc1 10.1016/j.bmcl.2008.08.009
CHEMBL490222 187056 None 0 Human Functional pEC50 = 6.9 6.9 -15 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 530 11 4 5 5.9 O=C(Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O)c1ccccc1 10.1016/j.bmcl.2008.08.009
45271036 197684 None 0 Human Functional pEC50 = 6.9 6.9 -2951 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
ChEMBL 526 11 4 7 3.8 CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3cccc(O)c3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1016/j.bmcl.2009.06.083
CHEMBL550871 197684 None 0 Human Functional pEC50 = 6.9 6.9 -2951 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
ChEMBL 526 11 4 7 3.8 CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3cccc(O)c3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1016/j.bmcl.2009.06.083
24895363 173695 None 0 Human Functional pEC50 = 6.9 6.9 -3162 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 447 11 3 4 5.3 CC(C)COc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL453322 173695 None 0 Human Functional pEC50 = 6.9 6.9 -3162 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 447 11 3 4 5.3 CC(C)COc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
24895261 186770 None 0 Human Functional pEC50 = 6.9 6.9 -676 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 435 10 4 6 3.7 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL488223 186770 None 0 Human Functional pEC50 = 6.9 6.9 -676 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 435 10 4 6 3.7 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O 10.1021/jm8000345
42639967 12516 None 0 Human Functional pEC50 = 6.9 6.9 -128 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 497 11 3 7 3.1 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL1186557 12516 None 0 Human Functional pEC50 = 6.9 6.9 -128 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 497 11 3 7 3.1 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL469610 12516 None 0 Human Functional pEC50 = 6.9 6.9 -128 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 497 11 3 7 3.1 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
44591506 179438 None 0 Human Functional pEC50 = 6.9 6.9 -676 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 435 10 4 6 3.7 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)O 10.1021/jm9000709
CHEMBL473495 179438 None 0 Human Functional pEC50 = 6.9 6.9 -676 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 435 10 4 6 3.7 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)O 10.1021/jm9000709
11152564 100069 None 0 Human Functional pEC50 = 6.9 6.9 -4 2
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 358 7 3 3 4.1 COc1cccc2c(C[C@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12 10.1016/s0960-894x(03)00073-8
CHEMBL286818 100069 None 0 Human Functional pEC50 = 6.9 6.9 -4 2
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 358 7 3 3 4.1 COc1cccc2c(C[C@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12 10.1016/s0960-894x(03)00073-8
44574651 178622 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 444 11 4 5 3.3 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1 10.1016/j.bmc.2009.03.044
CHEMBL466704 178622 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 444 11 4 5 3.3 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1 10.1016/j.bmc.2009.03.044
213051 92631 None 0 Human Functional pEC50 = 7.9 7.9 -4 2
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 402 9 4 4 3.5 C[C@@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
CHEMBL24350 92631 None 0 Human Functional pEC50 = 7.9 7.9 -4 2
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 402 9 4 4 3.5 C[C@@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
65772 60423 None 5 Human Functional pEC50 = 7.9 7.9 -5 11
Compound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptorCompound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptor
ChEMBL 345 5 3 6 2.6 COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC 10.1016/s0960-894x(00)00459-5
CHEMBL174984 60423 None 5 Human Functional pEC50 = 7.9 7.9 -5 11
Compound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptorCompound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptor
ChEMBL 345 5 3 6 2.6 COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC 10.1016/s0960-894x(00)00459-5
164623433 188679 None 0 Human Functional pEC50 = 7.8 7.8 -380 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL4870623 188679 None 0 Human Functional pEC50 = 7.8 7.8 -380 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL5028756 188679 None 0 Human Functional pEC50 = 7.8 7.8 -380 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
9804536 165792 None 0 Human Functional pEC50 = 7.8 7.8 -7 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 465 11 4 5 3.5 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1)c1ccccc1 10.1016/j.ejmech.2018.03.032
CHEMBL4245391 165792 None 0 Human Functional pEC50 = 7.8 7.8 -7 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 465 11 4 5 3.5 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1)c1ccccc1 10.1016/j.ejmech.2018.03.032
44574825 178703 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 534 13 3 6 4.8 O=C(Cc1nc2ccccc2n1Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL467298 178703 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 534 13 3 6 4.8 O=C(Cc1nc2ccccc2n1Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
45273276 198140 None 0 Human Functional pEC50 = 6.9 6.9 -2 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 429 10 4 5 3.6 N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1204005 198140 None 0 Human Functional pEC50 = 6.9 6.9 -2 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 429 10 4 5 3.6 N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL556689 198140 None 0 Human Functional pEC50 = 6.9 6.9 -2 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 429 10 4 5 3.6 N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
44579966 192727 None 0 Human Functional pEC50 = 6.9 6.9 -15 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 429 9 3 4 4.8 O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)ccc1F 10.1016/j.bmcl.2008.08.009
CHEMBL521611 192727 None 0 Human Functional pEC50 = 6.9 6.9 -15 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 429 9 3 4 4.8 O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)ccc1F 10.1016/j.bmcl.2008.08.009
24949572 177131 None 0 Human Functional pEC50 = 6.9 6.9 -34 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 438 7 3 5 4.4 O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)c1 10.1021/jm800222k
CHEMBL463182 177131 None 0 Human Functional pEC50 = 6.9 6.9 -34 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 438 7 3 5 4.4 O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)c1 10.1021/jm800222k
44565931 12449 None 0 Human Functional pEC50 = 6.9 6.9 -4677 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 552 11 4 8 3.6 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)cc1OC1CCCCC1 10.1021/jm9000709
CHEMBL1186040 12449 None 0 Human Functional pEC50 = 6.9 6.9 -4677 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 552 11 4 8 3.6 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)cc1OC1CCCCC1 10.1021/jm9000709
CHEMBL446806 12449 None 0 Human Functional pEC50 = 6.9 6.9 -4677 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 552 11 4 8 3.6 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)cc1OC1CCCCC1 10.1021/jm9000709
11381882 99356 None 0 Human Functional pEC50 = 6.9 6.9 2 2
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 328 6 3 2 4.1 C[C@@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
CHEMBL282039 99356 None 0 Human Functional pEC50 = 6.9 6.9 2 2
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 328 6 3 2 4.1 C[C@@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
155515718 170066 None 0 Human Functional pEC50 = 5.8 5.8 -2884 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 423 9 5 5 3.1 CC(C)C(=O)Nc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.bmc.2018.10.043
CHEMBL4441752 170066 None 0 Human Functional pEC50 = 5.8 5.8 -2884 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 423 9 5 5 3.1 CC(C)C(=O)Nc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.bmc.2018.10.043
24894317 173804 None 0 Human Functional pEC50 = 7.8 7.8 -22 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 467 11 3 4 5.6 CC(C)Cc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL453575 173804 None 0 Human Functional pEC50 = 7.8 7.8 -22 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 467 11 3 4 5.6 CC(C)Cc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
44392228 64883 None 0 Human Functional pEC50 = 7.8 7.8 -7 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 441 11 5 5 3.1 O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)NC1CCCCC1 10.1016/j.bmcl.2004.11.001
CHEMBL182127 64883 None 0 Human Functional pEC50 = 7.8 7.8 -7 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 441 11 5 5 3.1 O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)NC1CCCCC1 10.1016/j.bmcl.2004.11.001
1028 291 None 40 Guinea pig Functional pEC50 = 7.8 7.8 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
139148732 291 None 40 Guinea pig Functional pEC50 = 7.8 7.8 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
479 291 None 40 Guinea pig Functional pEC50 = 7.8 7.8 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
5816 291 None 40 Guinea pig Functional pEC50 = 7.8 7.8 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
5816.0 291 None 40 Guinea pig Functional pEC50 = 7.8 7.8 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
CHEMBL679 291 None 40 Guinea pig Functional pEC50 = 7.8 7.8 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
DB00668 291 None 40 Guinea pig Functional pEC50 = 7.8 7.8 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
155524038 170994 None 0 Human Functional pEC50 = 7.8 7.8 -120 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 414 8 4 4 4.2 O=c1ccc2c(C(O)CNCCCc3ccc(-c4ccccc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4454489 170994 None 0 Human Functional pEC50 = 7.8 7.8 -120 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 414 8 4 4 4.2 O=c1ccc2c(C(O)CNCCCc3ccc(-c4ccccc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
155550544 174413 None 0 Human Functional pEC50 = 7.8 7.8 -1 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 388 7 4 4 3.6 O=c1ccc2c(C(O)CNCCCc3ccc4ccccc4c3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4550290 174413 None 0 Human Functional pEC50 = 7.8 7.8 -1 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 388 7 4 4 3.6 O=c1ccc2c(C(O)CNCCCc3ccc4ccccc4c3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
44126933 198621 None 0 Human Functional pEC50 = 6.8 6.8 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 470 11 4 5 4.3 O=C(Cc1ccc2ccccc2c1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL561291 198621 None 0 Human Functional pEC50 = 6.8 6.8 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 470 11 4 5 4.3 O=C(Cc1ccc2ccccc2c1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
45268516 198699 None 0 Human Functional pEC50 = 6.8 6.8 -588 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
ChEMBL 605 13 5 9 2.8 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1016/j.bmcl.2009.06.083
CHEMBL561743 198699 None 0 Human Functional pEC50 = 6.8 6.8 -588 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
ChEMBL 605 13 5 9 2.8 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1016/j.bmcl.2009.06.083
16222940 186580 None 0 Human Functional pEC50 = 6.8 6.8 -2290 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 433 10 4 5 4.1 CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL487682 186580 None 0 Human Functional pEC50 = 6.8 6.8 -2290 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 433 10 4 5 4.1 CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3ccc(N)nc3)cc2)ccc1C(=O)O 10.1021/jm8000345
24895259 189405 None 0 Human Functional pEC50 = 6.8 6.8 -588 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 528 12 5 7 3.8 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL512147 189405 None 0 Human Functional pEC50 = 6.8 6.8 -588 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 528 12 5 7 3.8 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
44591507 179465 None 0 Human Functional pEC50 = 6.8 6.8 -2290 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 433 10 4 5 4.1 CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)O 10.1021/jm9000709
CHEMBL473702 179465 None 0 Human Functional pEC50 = 6.8 6.8 -2290 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 433 10 4 5 4.1 CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)O 10.1021/jm9000709
9842600 188222 None 0 Human Functional pEC50 = 5.8 5.8 -38 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 375 7 3 4 3.0 O=C(O)COc1ccc2c(c1)C[C@@H](NC[C@H](O)c1cccc(Cl)c1)CC2 10.1021/jm800222k
CHEMBL498305 188222 None 0 Human Functional pEC50 = 5.8 5.8 -38 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 375 7 3 4 3.0 O=C(O)COc1ccc2c(c1)C[C@@H](NC[C@H](O)c1cccc(Cl)c1)CC2 10.1021/jm800222k
44377535 55433 None 0 Human Functional pEC50 = 5.8 5.8 -117 2
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 508 8 4 9 2.8 O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)Oc4cccc5nc(O)ccc45)CC3)cc2)S1 10.1016/s0960-894x(01)00063-4
CHEMBL161949 55433 None 0 Human Functional pEC50 = 5.8 5.8 -117 2
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 508 8 4 9 2.8 O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)Oc4cccc5nc(O)ccc45)CC3)cc2)S1 10.1016/s0960-894x(01)00063-4
56673609 64124 None 0 Human Functional pEC50 = 6.8 6.8 -112 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 499 13 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3Cl)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807873 64124 None 0 Human Functional pEC50 = 6.8 6.8 -112 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 499 13 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3Cl)c2s1 10.1016/j.bmcl.2011.05.097
56672116 66386 None 0 Human Functional pEC50 = 6.8 6.8 -630 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 570 19 5 8 2.4 NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
CHEMBL1814276 66386 None 0 Human Functional pEC50 = 6.8 6.8 -630 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 570 19 5 8 2.4 NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
CHEMBL1851624 66386 None 0 Human Functional pEC50 = 6.8 6.8 -630 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 570 19 5 8 2.4 NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
44441227 148137 None 0 Human Functional pEC50 = 6.8 6.8 -10 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 9 4 6 3.8 C[C@H](CNc1cccc(-c2nc(C(=O)O)co2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL393469 148137 None 0 Human Functional pEC50 = 6.8 6.8 -10 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 9 4 6 3.8 C[C@H](CNc1cccc(-c2nc(C(=O)O)co2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
145981079 166777 None 0 Human Functional pEC50 = 5.8 5.8 -39 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 358 6 4 4 2.8 O=c1ccc2c(C(CO)NCCc3ccc(Cl)cc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2018.04.041
CHEMBL4282047 166777 None 0 Human Functional pEC50 = 5.8 5.8 -39 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 358 6 4 4 2.8 O=c1ccc2c(C(CO)NCCc3ccc(Cl)cc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2018.04.041
164626310 188702 None 0 Human Functional pEC50 = 7.8 7.8 -346 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL4874945 188702 None 0 Human Functional pEC50 = 7.8 7.8 -346 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL5028930 188702 None 0 Human Functional pEC50 = 7.8 7.8 -346 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
164614249 188601 None 0 Human Functional pEC50 = 7.8 7.8 -295 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4859591 188601 None 0 Human Functional pEC50 = 7.8 7.8 -295 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028241 188601 None 0 Human Functional pEC50 = 7.8 7.8 -295 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
24949889 188261 None 0 Human Functional pEC50 = 6.8 6.8 -35 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 451 7 3 4 5.4 O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CCC3)c1 10.1021/jm800222k
CHEMBL498531 188261 None 0 Human Functional pEC50 = 6.8 6.8 -35 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 451 7 3 4 5.4 O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CCC3)c1 10.1021/jm800222k
42639311 12528 None 0 Human Functional pEC50 = 6.8 6.8 -56 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 524 14 3 6 4.5 CCCCCOc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL1186600 12528 None 0 Human Functional pEC50 = 6.8 6.8 -56 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 524 14 3 6 4.5 CCCCCOc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL472089 12528 None 0 Human Functional pEC50 = 6.8 6.8 -56 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 524 14 3 6 4.5 CCCCCOc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
44392558 65276 None 0 Human Functional pEC50 = 6.8 6.8 -2 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 471 11 4 6 4.1 CC(C)=CCNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1 10.1016/j.bmcl.2004.12.033
CHEMBL182770 65276 None 0 Human Functional pEC50 = 6.8 6.8 -2 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 471 11 4 6 4.1 CC(C)=CCNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1 10.1016/j.bmcl.2004.12.033
44237669 58252 None 0 Rat Functional pEC50 = 5.8 5.8 -7943 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 540 9 6 5 4.7 O=C(NCc1c(Cl)cccc1Cl)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682217 58252 None 0 Rat Functional pEC50 = 5.8 5.8 -7943 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 540 9 6 5 4.7 O=C(NCc1c(Cl)cccc1Cl)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
9933039 163140 None 0 Human Functional pEC50 = 5.8 5.8 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 442 11 4 6 2.8 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL417613 163140 None 0 Human Functional pEC50 = 5.8 5.8 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 442 11 4 6 2.8 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
9933039 163140 None 0 Human Functional pEC50 = 5.8 5.8 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 442 11 4 6 2.8 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1 10.1016/j.ejmech.2009.01.022
CHEMBL417613 163140 None 0 Human Functional pEC50 = 5.8 5.8 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 442 11 4 6 2.8 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1 10.1016/j.ejmech.2009.01.022
44309523 102244 None 0 Human Functional pEC50 = 5.8 5.8 -52 3
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
ChEMBL 420 10 3 6 2.3 CCCCOc1ccc(S(=O)(=O)N2CC(NC[C@H](O)c3ccc(O)cc3)C2)cc1 10.1016/s0960-894x(03)00387-1
CHEMBL302803 102244 None 0 Human Functional pEC50 = 5.8 5.8 -52 3
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
ChEMBL 420 10 3 6 2.3 CCCCOc1ccc(S(=O)(=O)N2CC(NC[C@H](O)c3ccc(O)cc3)C2)cc1 10.1016/s0960-894x(03)00387-1
10601234 112070 None 0 Human Functional pEC50 = 5.8 5.8 -23 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 493 11 5 8 1.7 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(COCC(=O)O)cc3)CC2)ccc1O 10.1021/jm000544b
CHEMBL32888 112070 None 0 Human Functional pEC50 = 5.8 5.8 -23 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 493 11 5 8 1.7 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(COCC(=O)O)cc3)CC2)ccc1O 10.1021/jm000544b
10140889 6068 None 0 Human Functional pEC50 = 6.8 6.8 -4 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 484 12 4 6 3.3 CCN(CC)C(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL108061 6068 None 0 Human Functional pEC50 = 6.8 6.8 -4 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 484 12 4 6 3.3 CCN(CC)C(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
44574978 189399 None 0 Human Functional pEC50 = 6.8 6.8 -1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 524 12 2 6 4.0 O=C(Cc1nccn1Cc1ccccc1)N1CCCc2cc(CCNC[C@H](O)COc3ccccc3)ccc21 10.1016/j.bmc.2009.03.044
CHEMBL512099 189399 None 0 Human Functional pEC50 = 6.8 6.8 -1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 524 12 2 6 4.0 O=C(Cc1nccn1Cc1ccccc1)N1CCCc2cc(CCNC[C@H](O)COc3ccccc3)ccc21 10.1016/j.bmc.2009.03.044
24823464 97671 None 0 Human Functional pEC50 = 6.8 6.8 -588 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 418 10 4 4 4.7 CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm701324c
CHEMBL270964 97671 None 0 Human Functional pEC50 = 6.8 6.8 -588 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 418 10 4 4 4.7 CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm701324c
24823464 97671 None 0 Human Functional pEC50 = 6.8 6.8 -588 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 418 10 4 4 4.7 CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm9000709
CHEMBL270964 97671 None 0 Human Functional pEC50 = 6.8 6.8 -588 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 418 10 4 4 4.7 CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm9000709
44392457 166052 None 0 Human Functional pEC50 = 6.8 6.8 -34 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 457 11 4 6 3.7 C/C=C/CNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1 10.1016/j.bmcl.2004.12.033
CHEMBL425161 166052 None 0 Human Functional pEC50 = 6.8 6.8 -34 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 457 11 4 6 3.7 C/C=C/CNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1 10.1016/j.bmcl.2004.12.033
44127677 197861 None 0 Human Functional pEC50 = 5.8 5.8 -2 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 471 11 4 6 3.7 O=C(Cc1ccc2ccccc2n1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL552089 197861 None 0 Human Functional pEC50 = 5.8 5.8 -2 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 471 11 4 6 3.7 O=C(Cc1ccc2ccccc2n1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
567 725 None 16 Human Functional pEC50 = 5.8 5.8 -323 7
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 363 9 3 4 3.1 C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O 10.1016/s0960-894x(03)00073-8
9841972 725 None 16 Human Functional pEC50 = 5.8 5.8 -323 7
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 363 9 3 4 3.1 C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O 10.1016/s0960-894x(03)00073-8
CHEMBL284782 725 None 16 Human Functional pEC50 = 5.8 5.8 -323 7
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 363 9 3 4 3.1 C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O 10.1016/s0960-894x(03)00073-8
11703823 203612 None 0 Human Functional pEC50 = 6.8 6.8 -131 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 390 6 4 5 3.0 CC(C)(Cc1ccc(Cl)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL603274 203612 None 0 Human Functional pEC50 = 6.8 6.8 -131 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 390 6 4 5 3.0 CC(C)(Cc1ccc(Cl)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
24950234 176101 None 0 Human Functional pEC50 = 6.8 6.8 -223 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 494 10 4 5 5.8 CCCNc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1 10.1021/jm800222k
CHEMBL458923 176101 None 0 Human Functional pEC50 = 6.8 6.8 -223 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 494 10 4 5 5.8 CCCNc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1 10.1021/jm800222k
131487 4983 None 9 Guinea pig Functional pEC50 = 6.8 6.8 - 1
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 273 5 4 5 1.4 CC(C)(C)NCC(O)COc1cc(O)c(O)cc1F 10.1021/jm00107a027
CHEMBL10494 4983 None 9 Guinea pig Functional pEC50 = 6.8 6.8 - 1
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 273 5 4 5 1.4 CC(C)(C)NCC(O)COc1cc(O)c(O)cc1F 10.1021/jm00107a027
24822648 97660 None 0 Human Functional pEC50 = 7.8 7.8 -28 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 425 9 3 4 4.6 COc1cc(C(=O)O)ccc1-c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1 10.1021/jm701324c
CHEMBL270889 97660 None 0 Human Functional pEC50 = 7.8 7.8 -28 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 425 9 3 4 4.6 COc1cc(C(=O)O)ccc1-c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1 10.1021/jm701324c
45484558 199290 None 0 Human Functional pEC50 = 7.8 7.8 -4 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 498 11 8 7 1.6 CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL565770 199290 None 0 Human Functional pEC50 = 7.8 7.8 -4 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 498 11 8 7 1.6 CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
44574687 178626 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 406 11 3 6 2.2 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccnc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL466713 178626 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 406 11 3 6 2.2 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccnc2)cc1 10.1016/j.bmc.2009.03.044
44219629 178674 None 0 Human Functional pEC50 = 6.8 6.8 -1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 484 13 3 6 3.7 O=C(Cc1nccn1Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL467083 178674 None 0 Human Functional pEC50 = 6.8 6.8 -1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 484 13 3 6 3.7 O=C(Cc1nccn1Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
44126931 197810 None 0 Human Functional pEC50 = 6.8 6.8 -1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 496 12 4 5 4.7 O=C(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2009.01.022
CHEMBL551831 197810 None 0 Human Functional pEC50 = 6.8 6.8 -1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 496 12 4 5 4.7 O=C(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2009.01.022
24895664 176801 None 0 Human Functional pEC50 = 6.8 6.8 -251 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 467 12 3 4 5.8 CCCOc1cc(-c2ccc(CCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL459863 176801 None 0 Human Functional pEC50 = 6.8 6.8 -251 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 467 12 3 4 5.8 CCCOc1cc(-c2ccc(CCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
44396568 67307 None 0 Human Functional pEC50 = 6.8 6.8 -34 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 529 12 5 7 3.7 C[C@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
CHEMBL188196 67307 None 0 Human Functional pEC50 = 6.8 6.8 -34 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 529 12 5 7 3.7 C[C@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
9853471 207312 None 0 Human Functional pEC50 = 5.8 5.8 -389 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1 10.1016/s0960-894x(00)00459-5
CHEMBL75604 207312 None 0 Human Functional pEC50 = 5.8 5.8 -389 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1 10.1016/s0960-894x(00)00459-5
44331425 4446 None 0 Human Functional pEC50 = 5.7 5.7 -186 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 576 13 6 8 2.5 CC(C)C[C@H](NC(=O)c1ccc(N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1)C(=O)O 10.1016/s0960-894x(02)00608-x
CHEMBL101630 4446 None 0 Human Functional pEC50 = 5.7 5.7 -186 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 576 13 6 8 2.5 CC(C)C[C@H](NC(=O)c1ccc(N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1)C(=O)O 10.1016/s0960-894x(02)00608-x
45483838 199388 None 0 Human Functional pEC50 = 5.7 5.7 -14 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 383 7 4 4 3.5 CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2009.10.013
CHEMBL566352 199388 None 0 Human Functional pEC50 = 5.7 5.7 -14 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 383 7 4 4 3.5 CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2009.10.013
10302342 109842 None 0 Human Functional pEC50 = 6.7 6.7 -3 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 538 14 5 6 4.5 O=C(NCCCC1CCCC1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL323258 109842 None 0 Human Functional pEC50 = 6.7 6.7 -3 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 538 14 5 6 4.5 O=C(NCCCC1CCCC1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
44396488 66752 None 0 Human Functional pEC50 = 7.7 7.7 -14 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 556 12 4 7 3.8 C[C@H](Cc1c[nH]c2c(OCC(=O)N(C)C)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
CHEMBL185703 66752 None 0 Human Functional pEC50 = 7.7 7.7 -14 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 556 12 4 7 3.8 C[C@H](Cc1c[nH]c2c(OCC(=O)N(C)C)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
9831168 207160 None 0 Human Functional pEC50 = 7.7 7.7 -2 3
Percent adenylyl cyclase activation at 10000 nM of compound concentrationPercent adenylyl cyclase activation at 10000 nM of compound concentration
ChEMBL 552 11 6 6 5.0 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)cc1 10.1016/s0960-894x(00)00459-5
CHEMBL74085 207160 None 0 Human Functional pEC50 = 7.7 7.7 -2 3
Percent adenylyl cyclase activation at 10000 nM of compound concentrationPercent adenylyl cyclase activation at 10000 nM of compound concentration
ChEMBL 552 11 6 6 5.0 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)cc1 10.1016/s0960-894x(00)00459-5
11005613 119863 None 0 Human Functional pEC50 = 7.7 7.7 -1 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 501 12 4 5 4.3 Cc1ccc(S(=O)(=O)NCCc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm0101500
CHEMBL348269 119863 None 0 Human Functional pEC50 = 7.7 7.7 -1 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 501 12 4 5 4.3 Cc1ccc(S(=O)(=O)NCCc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm0101500
44441234 93842 None 0 Human Functional pEC50 = 7.7 7.7 -63 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 414 9 4 5 4.4 C[C@H](CNc1ccc(-c2occc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL247520 93842 None 0 Human Functional pEC50 = 7.7 7.7 -63 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 414 9 4 5 4.4 C[C@H](CNc1ccc(-c2occc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
44441228 167875 None 0 Human Functional pEC50 = 7.7 7.7 -3 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 431 9 4 6 4.3 C[C@H](CNc1ccc(-c2nc(C(=O)O)cs2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL430390 167875 None 0 Human Functional pEC50 = 7.7 7.7 -3 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 431 9 4 6 4.3 C[C@H](CNc1ccc(-c2nc(C(=O)O)cs2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
46832507 14219 None 0 Human Functional pEC50 = 7.7 7.7 -12 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 475 17 6 7 2.8 NC(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL1085638 14219 None 0 Human Functional pEC50 = 7.7 7.7 -12 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 475 17 6 7 2.8 NC(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL1198915 14219 None 0 Human Functional pEC50 = 7.7 7.7 -12 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 475 17 6 7 2.8 NC(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
10203169 14244 None 0 Human Functional pEC50 = 7.7 7.7 -25 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 433 16 5 7 3.0 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc(O)c2)ccc1O 10.1021/jm100326d
CHEMBL1086536 14244 None 0 Human Functional pEC50 = 7.7 7.7 -25 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 433 16 5 7 3.0 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc(O)c2)ccc1O 10.1021/jm100326d
CHEMBL1199300 14244 None 0 Human Functional pEC50 = 7.7 7.7 -25 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 433 16 5 7 3.0 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc(O)c2)ccc1O 10.1021/jm100326d
44574867 178678 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 562 13 3 6 4.4 O=C(Cc1nccn1Cc1ccc(Br)cc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL467102 178678 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 562 13 3 6 4.4 O=C(Cc1nccn1Cc1ccc(Br)cc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
44579650 187261 None 0 Human Functional pEC50 = 6.7 6.7 -15 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 435 10 4 6 3.4 CC(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
CHEMBL492005 187261 None 0 Human Functional pEC50 = 6.7 6.7 -15 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 435 10 4 6 3.4 CC(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
44580041 193417 None 0 Human Functional pEC50 = 6.7 6.7 -9 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 530 11 4 5 5.9 O=C(O)c1cc(NC(=O)c2ccccc2)cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)c1 10.1016/j.bmcl.2008.08.009
CHEMBL524145 193417 None 0 Human Functional pEC50 = 6.7 6.7 -9 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 530 11 4 5 5.9 O=C(O)c1cc(NC(=O)c2ccccc2)cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)c1 10.1016/j.bmcl.2008.08.009
44127480 199013 None 0 Human Functional pEC50 = 6.7 6.7 6 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 454 11 4 5 3.8 O=C(Cc1ccc(Cl)cc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL563810 199013 None 0 Human Functional pEC50 = 6.7 6.7 6 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 454 11 4 5 3.8 O=C(Cc1ccc(Cl)cc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
44560793 189005 None 0 Human Functional pEC50 = 6.7 6.7 -2951 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 434 11 3 5 4.5 CCCOc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccnc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL507506 189005 None 0 Human Functional pEC50 = 6.7 6.7 -2951 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 434 11 3 5 4.5 CCCOc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccnc3)cc2)ccc1C(=O)O 10.1021/jm8000345
9873257 84979 None 14 Human Functional pEC50 = 5.7 5.7 -74 3
Agonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclaseAgonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase
ChEMBL 591 14 3 10 3.5 O=c1n(CCCC2CCCC2)nnn1-c1ccc(S(=O)(=O)Nc2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1 10.1016/s0960-894x(99)00182-1
CHEMBL22375 84979 None 14 Human Functional pEC50 = 5.7 5.7 -74 3
Agonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclaseAgonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase
ChEMBL 591 14 3 10 3.5 O=c1n(CCCC2CCCC2)nnn1-c1ccc(S(=O)(=O)Nc2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1 10.1016/s0960-894x(99)00182-1
155527926 171356 None 0 Human Functional pEC50 = 5.7 5.7 -8709 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 451 11 5 5 3.9 CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmc.2018.10.043
CHEMBL4460095 171356 None 0 Human Functional pEC50 = 5.7 5.7 -8709 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 451 11 5 5 3.9 CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmc.2018.10.043
164612026 185475 None 0 Human Functional pEC50 = 6.7 6.7 -776 2
Agonist activity at human beta1 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at human beta1 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assay
ChEMBL 237 4 3 4 1.3 CC(C)NC(CO)c1cc(F)c(N)c(C#N)c1 10.1021/acs.jmedchem.0c01195
CHEMBL4860455 185475 None 0 Human Functional pEC50 = 6.7 6.7 -776 2
Agonist activity at human beta1 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at human beta1 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assay
ChEMBL 237 4 3 4 1.3 CC(C)NC(CO)c1cc(F)c(N)c(C#N)c1 10.1021/acs.jmedchem.0c01195
56670092 64125 None 0 Human Functional pEC50 = 6.7 6.7 -112 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 445 13 4 7 2.5 CN(CCOCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)CCc1ccccc1 10.1016/j.bmcl.2011.05.097
CHEMBL1807874 64125 None 0 Human Functional pEC50 = 6.7 6.7 -112 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 445 13 4 7 2.5 CN(CCOCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)CCc1ccccc1 10.1016/j.bmcl.2011.05.097
56675509 64517 None 0 Human Functional pEC50 = 6.7 6.7 -79 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CNC(=O)N1c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmc.2011.05.064
CHEMBL1814270 64517 None 0 Human Functional pEC50 = 6.7 6.7 -79 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CNC(=O)N1c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmc.2011.05.064
53357712 66428 None 0 Human Functional pEC50 = 6.7 6.7 -251 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 541 17 5 7 3.9 CC1(C)NC(=O)N(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
CHEMBL1814271 66428 None 0 Human Functional pEC50 = 6.7 6.7 -251 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 541 17 5 7 3.9 CC1(C)NC(=O)N(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
CHEMBL1851848 66428 None 0 Human Functional pEC50 = 6.7 6.7 -251 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 541 17 5 7 3.9 CC1(C)NC(=O)N(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
56658244 66429 None 0 Human Functional pEC50 = 6.7 6.7 -79 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1 10.1016/j.bmc.2011.05.064
CHEMBL1814272 66429 None 0 Human Functional pEC50 = 6.7 6.7 -79 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1 10.1016/j.bmc.2011.05.064
CHEMBL1851849 66429 None 0 Human Functional pEC50 = 6.7 6.7 -79 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1 10.1016/j.bmc.2011.05.064
9958539 103160 None 0 Human Functional pEC50 = 8.7 8.7 -5 3
Percent adenylyl cyclase activation at 10000 nM of compound concentrationPercent adenylyl cyclase activation at 10000 nM of compound concentration
ChEMBL 527 3 2 5 3.4 COc1c(I)cc(CC2NCCc3nc(N)sc32)cc1I 10.1016/s0960-894x(00)00459-5
CHEMBL307647 103160 None 0 Human Functional pEC50 = 8.7 8.7 -5 3
Percent adenylyl cyclase activation at 10000 nM of compound concentrationPercent adenylyl cyclase activation at 10000 nM of compound concentration
ChEMBL 527 3 2 5 3.4 COc1c(I)cc(CC2NCCc3nc(N)sc32)cc1I 10.1016/s0960-894x(00)00459-5
164615222 188613 None 0 Human Functional pEC50 = 8.7 8.7 -91 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4857267 188613 None 0 Human Functional pEC50 = 8.7 8.7 -91 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028301 188613 None 0 Human Functional pEC50 = 8.7 8.7 -91 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164615492 188616 None 0 Human Functional pEC50 = 8.7 8.7 -120 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4848704 188616 None 0 Human Functional pEC50 = 8.7 8.7 -120 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028319 188616 None 0 Human Functional pEC50 = 8.7 8.7 -120 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
443372 10236 None 19 Guinea pig Functional pEC50 = 8.7 8.7 -8 9
Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.
ChEMBL 211 4 4 4 1.1 CC(C)NC[C@H](O)c1ccc(O)c(O)c1 10.1021/jm00019a001
CHEMBL1160723 10236 None 19 Guinea pig Functional pEC50 = 8.7 8.7 -8 9
Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.
ChEMBL 211 4 4 4 1.1 CC(C)NC[C@H](O)c1ccc(O)c(O)c1 10.1021/jm00019a001
CHEMBL2062275 10236 None 19 Guinea pig Functional pEC50 = 8.7 8.7 -8 9
Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.
ChEMBL 211 4 4 4 1.1 CC(C)NC[C@H](O)c1ccc(O)c(O)c1 10.1021/jm00019a001
44392215 65623 None 0 Human Functional pEC50 = 8.7 8.7 1 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 465 12 5 6 3.3 COc1ccc(NC(=O)Nc2ccc(C[C@@H](CO)NC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmcl.2004.11.001
CHEMBL183307 65623 None 0 Human Functional pEC50 = 8.7 8.7 1 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 465 12 5 6 3.3 COc1ccc(NC(=O)Nc2ccc(C[C@@H](CO)NC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmcl.2004.11.001
5311116 2334 None 9 Human Functional pEC50 = 8.6 8.6 4365 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 484 15 5 8 2.2 N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O 10.1021/jm400348g
544 2334 None 9 Human Functional pEC50 = 8.6 8.6 4365 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 484 15 5 8 2.2 N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O 10.1021/jm400348g
CHEMBL207802 2334 None 9 Human Functional pEC50 = 8.6 8.6 4365 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 484 15 5 8 2.2 N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O 10.1021/jm400348g
56598832 88302 None 0 Human Functional pEC50 = 8.6 8.6 4365 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 527 16 5 7 3.3 O=C(NCCNCC(O)COc1ccc(OCCOCCc2ccc(F)cc2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
CHEMBL2348218 88302 None 0 Human Functional pEC50 = 8.6 8.6 4365 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 527 16 5 7 3.3 O=C(NCCNCC(O)COc1ccc(OCCOCCc2ccc(F)cc2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
164617772 188631 None 0 Human Functional pEC50 = 8.6 8.6 -173 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4848793 188631 None 0 Human Functional pEC50 = 8.6 8.6 -173 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028458 188631 None 0 Human Functional pEC50 = 8.6 8.6 -173 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164611794 188582 None 0 Human Functional pEC50 = 8.6 8.6 -131 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4854261 188582 None 0 Human Functional pEC50 = 8.6 8.6 -131 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028104 188582 None 0 Human Functional pEC50 = 8.6 8.6 -131 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
10289065 12549 None 0 Guinea pig Functional pEC50 = 8.6 8.6 - 1
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1186683 12549 None 0 Guinea pig Functional pEC50 = 8.6 8.6 - 1
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL474616 12549 None 0 Guinea pig Functional pEC50 = 8.6 8.6 - 1
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
42625511 12741 None 0 Guinea pig Functional pEC50 = 8.6 8.6 -3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1 10.1021/jm801016j
CHEMBL1187778 12741 None 0 Guinea pig Functional pEC50 = 8.6 8.6 -3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1 10.1021/jm801016j
CHEMBL520313 12741 None 0 Guinea pig Functional pEC50 = 8.6 8.6 -3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1 10.1021/jm801016j
90645344 112519 None 0 Human Functional pEC50 = 8.6 8.6 -7 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1CN 10.1016/j.bmcl.2014.04.095
CHEMBL3298324 112519 None 0 Human Functional pEC50 = 8.6 8.6 -7 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1CN 10.1016/j.bmcl.2014.04.095
10239722 112521 None 0 Human Functional pEC50 = 8.6 8.6 -11 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298326 112521 None 0 Human Functional pEC50 = 8.6 8.6 -11 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1 10.1016/j.bmcl.2014.04.095
164621302 188658 None 0 Human Functional pEC50 = 8.6 8.6 -120 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL4863282 188658 None 0 Human Functional pEC50 = 8.6 8.6 -120 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL5028641 188658 None 0 Human Functional pEC50 = 8.6 8.6 -120 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
164610792 188575 None 0 Human Functional pEC50 = 8.6 8.6 -134 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL4855974 188575 None 0 Human Functional pEC50 = 8.6 8.6 -134 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL5028040 188575 None 0 Human Functional pEC50 = 8.6 8.6 -134 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
145984584 165982 None 0 Human Functional pEC50 = 8.5 8.5 -5 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 444 10 5 4 4.4 O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1 10.1016/j.ejmech.2018.03.032
CHEMBL4249564 165982 None 0 Human Functional pEC50 = 8.5 8.5 -5 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 444 10 5 4 4.4 O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1 10.1016/j.ejmech.2018.03.032
24822643 157746 None 0 Human Functional pEC50 = 7.7 7.7 -4 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 413 8 3 3 4.7 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c(F)c1 10.1021/jm701324c
CHEMBL408145 157746 None 0 Human Functional pEC50 = 7.7 7.7 -4 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 413 8 3 3 4.7 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c(F)c1 10.1021/jm701324c
44392212 168472 None 0 Human Functional pEC50 = 7.7 7.7 12 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 405 10 4 4 3.9 O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1204383 168472 None 0 Human Functional pEC50 = 7.7 7.7 12 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 405 10 4 4 3.9 O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL434524 168472 None 0 Human Functional pEC50 = 7.7 7.7 12 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 405 10 4 4 3.9 O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
45271492 197690 None 0 Human Functional pEC50 = 7.7 7.7 16 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 390 10 3 4 3.5 O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1203997 197690 None 0 Human Functional pEC50 = 7.7 7.7 16 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 390 10 3 4 3.5 O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL550906 197690 None 0 Human Functional pEC50 = 7.7 7.7 16 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 390 10 3 4 3.5 O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
10113837 65590 None 0 Human Functional pEC50 = 7.7 7.7 -39 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 435 11 5 5 3.3 O=C(Nc1ccccc1)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
CHEMBL183129 65590 None 0 Human Functional pEC50 = 7.7 7.7 -39 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 435 11 5 5 3.3 O=C(Nc1ccccc1)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
44396531 66856 None 0 Human Functional pEC50 = 7.7 7.7 -38 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 647 18 4 8 6.4 CCCCCCCCS(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12 10.1016/j.bmcl.2004.10.035
CHEMBL186135 66856 None 0 Human Functional pEC50 = 7.7 7.7 -38 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 647 18 4 8 6.4 CCCCCCCCS(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12 10.1016/j.bmcl.2004.10.035
24822469 97830 None 0 Human Functional pEC50 = 6.7 6.7 -26 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 401 8 3 4 4.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)s1 10.1021/jm701324c
CHEMBL271765 97830 None 0 Human Functional pEC50 = 6.7 6.7 -26 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 401 8 3 4 4.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)s1 10.1021/jm701324c
24950568 189874 None 0 Human Functional pEC50 = 6.7 6.7 -234 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 422 6 3 4 4.3 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)cc1 10.1021/jm800222k
CHEMBL516002 189874 None 0 Human Functional pEC50 = 6.7 6.7 -234 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 422 6 3 4 4.3 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)cc1 10.1021/jm800222k
11625493 203168 None 1 Human Functional pEC50 = 6.7 6.7 -12 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 400 8 4 6 2.8 CCOc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.12.087
CHEMBL600007 203168 None 1 Human Functional pEC50 = 6.7 6.7 -12 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 400 8 4 6 2.8 CCOc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.12.087
44565908 187230 None 0 Human Functional pEC50 = 6.7 6.7 -1513 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 512 11 4 8 2.7 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL491726 187230 None 0 Human Functional pEC50 = 6.7 6.7 -1513 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 512 11 4 8 2.7 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
10139127 57506 None 0 Human Functional pEC50 = 5.7 5.7 -50 2
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 455 9 3 7 2.6 O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)COc4ccccc4)CC3)cc2)S1 10.1016/s0960-894x(01)00063-4
CHEMBL165893 57506 None 0 Human Functional pEC50 = 5.7 5.7 -50 2
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 455 9 3 7 2.6 O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)COc4ccccc4)CC3)cc2)S1 10.1016/s0960-894x(01)00063-4
44589133 175948 None 0 Human Functional pEC50 = 5.7 5.7 -2 3
Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor
ChEMBL 354 8 2 4 3.4 CC(C)NCC(O)COc1ccc2c(c1)CCCN2Cc1ccccc1 10.1016/j.bmc.2008.11.030
CHEMBL458541 175948 None 0 Human Functional pEC50 = 5.7 5.7 -2 3
Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor
ChEMBL 354 8 2 4 3.4 CC(C)NCC(O)COc1ccc2c(c1)CCCN2Cc1ccccc1 10.1016/j.bmc.2008.11.030
10145446 4184 None 0 Human Functional pEC50 = 5.7 5.7 -102 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 602 14 5 8 3.6 O=C(NCCCc1cccs1)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
CHEMBL100124 4184 None 0 Human Functional pEC50 = 5.7 5.7 -102 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 602 14 5 8 3.6 O=C(NCCCc1cccs1)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
46232816 203411 None 0 Human Functional pEC50 = 6.7 6.7 -3 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 432 7 4 5 4.0 CC(C)(Cc1ccc(-c2ccccc2)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL601858 203411 None 0 Human Functional pEC50 = 6.7 6.7 -3 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 432 7 4 5 4.0 CC(C)(Cc1ccc(-c2ccccc2)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
11632691 203999 None 0 Human Functional pEC50 = 6.7 6.7 -3 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 398 7 4 5 3.5 CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.12.087
CHEMBL605372 203999 None 0 Human Functional pEC50 = 6.7 6.7 -3 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 398 7 4 5 3.5 CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.12.087
44377523 56247 None 0 Human Functional pEC50 = 7.7 7.7 1 2
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 509 9 3 8 1.0 O=C1N=c2cccc(OC[C@@H](O)CNC3CCN(c4ccc(CC5SC(=O)NC5=O)cc4)CC3)c2=N1 10.1016/s0960-894x(01)00063-4
CHEMBL162711 56247 None 0 Human Functional pEC50 = 7.7 7.7 1 2
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 509 9 3 8 1.0 O=C1N=c2cccc(OC[C@@H](O)CNC3CCN(c4ccc(CC5SC(=O)NC5=O)cc4)CC3)c2=N1 10.1016/s0960-894x(01)00063-4
9933039 163140 None 0 Human Functional pEC50 = 6.7 6.7 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 442 11 4 6 2.8 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL417613 163140 None 0 Human Functional pEC50 = 6.7 6.7 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 442 11 4 6 2.8 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
24895563 176843 None 0 Human Functional pEC50 = 6.7 6.7 -173 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 435 12 3 5 4.5 CCCOc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL460256 176843 None 0 Human Functional pEC50 = 6.7 6.7 -173 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 435 12 3 5 4.5 CCCOc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
11668125 203468 None 0 Human Functional pEC50 = 6.7 6.7 -4 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 384 7 4 5 2.9 CCc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.12.087
CHEMBL602258 203468 None 0 Human Functional pEC50 = 6.7 6.7 -4 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 384 7 4 5 2.9 CCc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.12.087
155536314 172278 None 0 Human Functional pEC50 = 6.7 6.7 -6025 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4473515 172278 None 0 Human Functional pEC50 = 6.7 6.7 -6025 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
24895789 188975 None 0 Human Functional pEC50 = 7.7 7.7 -72 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 375 8 3 3 4.3 C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1ccccc1 10.1021/jm8000345
CHEMBL507003 188975 None 0 Human Functional pEC50 = 7.7 7.7 -72 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 375 8 3 3 4.3 C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1ccccc1 10.1021/jm8000345
44396715 67472 None 0 Human Functional pEC50 = 7.7 7.7 -20 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 612 12 4 9 4.4 C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3cccnc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
CHEMBL189081 67472 None 0 Human Functional pEC50 = 7.7 7.7 -20 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 612 12 4 9 4.4 C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3cccnc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
155551006 174049 None 0 Human Functional pEC50 = 7.7 7.7 -44 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 423 9 5 5 3.1 CC(C)C(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmc.2018.10.043
CHEMBL4541169 174049 None 0 Human Functional pEC50 = 7.7 7.7 -44 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 423 9 5 5 3.1 CC(C)C(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmc.2018.10.043
164620585 188652 None 0 Human Functional pEC50 = 7.7 7.7 -616 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4866766 188652 None 0 Human Functional pEC50 = 7.7 7.7 -616 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028602 188652 None 0 Human Functional pEC50 = 7.7 7.7 -616 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
56598833 88301 None 0 Human Functional pEC50 = 7.6 7.6 436 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 433 14 5 7 2.0 CCOCCOc1ccc(OCC(O)CNCCNC(=O)Nc2ccc(O)cc2)cc1 10.1021/jm400348g
CHEMBL2348217 88301 None 0 Human Functional pEC50 = 7.6 7.6 436 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 433 14 5 7 2.0 CCOCCOc1ccc(OCC(O)CNCCNC(=O)Nc2ccc(O)cc2)cc1 10.1021/jm400348g
42639314 12574 None 0 Human Functional pEC50 = 6.7 6.7 -575 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 550 11 3 6 5.0 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCCC1 10.1021/jm9000709
CHEMBL1186804 12574 None 0 Human Functional pEC50 = 6.7 6.7 -575 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 550 11 3 6 5.0 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCCC1 10.1021/jm9000709
CHEMBL479341 12574 None 0 Human Functional pEC50 = 6.7 6.7 -575 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 550 11 3 6 5.0 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCCC1 10.1021/jm9000709
443372 10236 None 19 Guinea pig Functional pEC50 = 5.7 5.7 -8 9
Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.
ChEMBL 211 4 4 4 1.1 CC(C)NC[C@H](O)c1ccc(O)c(O)c1 10.1021/jm00019a001
CHEMBL1160723 10236 None 19 Guinea pig Functional pEC50 = 5.7 5.7 -8 9
Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.
ChEMBL 211 4 4 4 1.1 CC(C)NC[C@H](O)c1ccc(O)c(O)c1 10.1021/jm00019a001
CHEMBL2062275 10236 None 19 Guinea pig Functional pEC50 = 5.7 5.7 -8 9
Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.
ChEMBL 211 4 4 4 1.1 CC(C)NC[C@H](O)c1ccc(O)c(O)c1 10.1021/jm00019a001
145983266 165623 None 0 Human Functional pEC50 = 6.7 6.7 -66 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 512 14 5 6 2.7 CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NS(=O)(=O)Nc3ccccc3)cc2)c1 10.1016/j.ejmech.2018.03.032
CHEMBL4241176 165623 None 0 Human Functional pEC50 = 6.7 6.7 -66 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 512 14 5 6 2.7 CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NS(=O)(=O)Nc3ccccc3)cc2)c1 10.1016/j.ejmech.2018.03.032
319 1324 None 32 Rat Functional pEC50 = 5.6 5.6 -2290 18
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2010.12.096
321 1324 None 32 Rat Functional pEC50 = 5.6 5.6 -2290 18
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2010.12.096
444031 1324 None 32 Rat Functional pEC50 = 5.6 5.6 -2290 18
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2010.12.096
444031.0 1324 None 32 Rat Functional pEC50 = 5.6 5.6 -2290 18
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2010.12.096
784 1324 None 32 Rat Functional pEC50 = 5.6 5.6 -2290 18
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2010.12.096
CHEMBL1346 1324 None 32 Rat Functional pEC50 = 5.6 5.6 -2290 18
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2010.12.096
DB00496 1324 None 32 Rat Functional pEC50 = 5.6 5.6 -2290 18
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2010.12.096
155543518 175102 None 0 Human Functional pEC50 = 6.6 6.6 -794 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 457 9 5 5 3.7 O=C(Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)c1ccccc1 10.1016/j.bmc.2018.10.043
CHEMBL4566727 175102 None 0 Human Functional pEC50 = 6.6 6.6 -794 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 457 9 5 5 3.7 O=C(Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)c1ccccc1 10.1016/j.bmc.2018.10.043
45101521 199283 None 0 Human Functional pEC50 = 7.6 7.6 -4 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 570 15 8 9 1.3 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C(N)CCCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL565747 199283 None 0 Human Functional pEC50 = 7.6 7.6 -4 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 570 15 8 9 1.3 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C(N)CCCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
44560794 173605 None 0 Human Functional pEC50 = 7.6 7.6 -346 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 474 10 3 5 5.4 C[C@H](Cc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1)NC[C@H](O)c1cccnc1 10.1021/jm8000345
CHEMBL453056 173605 None 0 Human Functional pEC50 = 7.6 7.6 -346 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 474 10 3 5 5.4 C[C@H](Cc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1)NC[C@H](O)c1cccnc1 10.1021/jm8000345
164623230 188678 None 0 Human Functional pEC50 = 7.6 7.6 -1479 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4865710 188678 None 0 Human Functional pEC50 = 7.6 7.6 -1479 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028744 188678 None 0 Human Functional pEC50 = 7.6 7.6 -1479 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
44579940 192001 None 0 Human Functional pEC50 = 6.6 6.6 -37 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 468 10 4 5 4.7 CC(=O)Nc1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc(C(=O)O)c1 10.1016/j.bmcl.2008.08.009
CHEMBL519985 192001 None 0 Human Functional pEC50 = 6.6 6.6 -37 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 468 10 4 5 4.7 CC(=O)Nc1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc(C(=O)O)c1 10.1016/j.bmcl.2008.08.009
46232857 203214 None 0 Human Functional pEC50 = 6.6 6.6 -19 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 440 7 4 6 3.3 CC(C)(Cc1ccc(OC(F)(F)F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL600400 203214 None 0 Human Functional pEC50 = 6.6 6.6 -19 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 440 7 4 6 3.3 CC(C)(Cc1ccc(OC(F)(F)F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
42639654 12644 None 0 Human Functional pEC50 = 6.6 6.6 -1258 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 513 11 3 7 3.8 CC(C)Sc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL1187156 12644 None 0 Human Functional pEC50 = 6.6 6.6 -1258 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 513 11 3 7 3.8 CC(C)Sc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL491891 12644 None 0 Human Functional pEC50 = 6.6 6.6 -1258 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 513 11 3 7 3.8 CC(C)Sc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
164615990 185408 None 0 Human Functional pEC50 = 5.6 5.6 -831 2
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by immunoassayAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by immunoassay
ChEMBL 427 9 5 6 1.6 CN(C)C(=O)CNc1ccc2c(c1)C[C@@H](NC[C@H](O)c1ccc(O)c(CCO)c1)CC2 10.1021/acs.jmedchem.0c01195
CHEMBL4859326 185408 None 0 Human Functional pEC50 = 5.6 5.6 -831 2
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by immunoassayAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by immunoassay
ChEMBL 427 9 5 6 1.6 CN(C)C(=O)CNc1ccc2c(c1)C[C@@H](NC[C@H](O)c1ccc(O)c(CCO)c1)CC2 10.1021/acs.jmedchem.0c01195
9832011 105537 None 0 Human Functional pEC50 = 5.6 5.6 -138 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
ChEMBL 644 13 6 7 6.5 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(OCC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1 10.1016/s0960-894x(00)00459-5
CHEMBL312074 105537 None 0 Human Functional pEC50 = 5.6 5.6 -138 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
ChEMBL 644 13 6 7 6.5 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(OCC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1 10.1016/s0960-894x(00)00459-5
11091850 47245 None 0 Human Functional pEC50 = 7.6 7.6 -25 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 465 11 4 4 4.6 Cc1ccc(CNC(=O)Cc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm0101500
CHEMBL154370 47245 None 0 Human Functional pEC50 = 7.6 7.6 -25 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 465 11 4 4 4.6 Cc1ccc(CNC(=O)Cc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm0101500
44441232 93841 None 0 Human Functional pEC50 = 7.6 7.6 -19 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 9 4 6 3.8 C[C@H](CNc1ccc(-c2ocnc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL247519 93841 None 0 Human Functional pEC50 = 7.6 7.6 -19 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 9 4 6 3.8 C[C@H](CNc1ccc(-c2ocnc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
9892481 70257 None 12 Human Functional pEC50 = 7.6 7.6 -501 4
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 435 12 6 6 3.0 O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2014.04.095
CHEMBL1940832 70257 None 12 Human Functional pEC50 = 7.6 7.6 -501 4
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 435 12 6 6 3.0 O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2014.04.095
9849126 12443 None 0 Human Functional pEC50 = 7.6 7.6 -630 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
CHEMBL1185969 12443 None 0 Human Functional pEC50 = 7.6 7.6 -630 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
CHEMBL443435 12443 None 0 Human Functional pEC50 = 7.6 7.6 -630 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
9892481 70257 None 12 Human Functional pEC50 = 7.6 7.6 -501 4
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 435 12 6 6 3.0 O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.11.072
CHEMBL1940832 70257 None 12 Human Functional pEC50 = 7.6 7.6 -501 4
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 435 12 6 6 3.0 O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.11.072
44574720 178655 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 494 11 4 5 4.5 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]c4ccccc4c23)cc1 10.1016/j.bmc.2009.03.044
CHEMBL466923 178655 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 494 11 4 5 4.5 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]c4ccccc4c23)cc1 10.1016/j.bmc.2009.03.044
49861320 54982 None 0 Human Functional pEC50 = 6.6 6.6 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 426 11 3 5 3.1 O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1204003 54982 None 0 Human Functional pEC50 = 6.6 6.6 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 426 11 3 5 3.1 O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1615579 54982 None 0 Human Functional pEC50 = 6.6 6.6 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 426 11 3 5 3.1 O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
10048077 97947 None 16 Human Functional pEC50 = 6.6 6.6 -52 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 425 9 3 4 4.6 COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm9000709
CHEMBL272383 97947 None 16 Human Functional pEC50 = 6.6 6.6 -52 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 425 9 3 4 4.6 COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm9000709
44574757 178590 None 0 Human Functional pEC50 = 5.6 5.6 -12 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 511 14 3 6 4.4 O=C(Cc1cccc(OCc2ccccc2)n1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL466467 178590 None 0 Human Functional pEC50 = 5.6 5.6 -12 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 511 14 3 6 4.4 O=C(Cc1cccc(OCc2ccccc2)n1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
10048077 97947 None 16 Human Functional pEC50 = 6.6 6.6 -52 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 425 9 3 4 4.6 COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm701324c
CHEMBL272383 97947 None 16 Human Functional pEC50 = 6.6 6.6 -52 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 425 9 3 4 4.6 COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm701324c
11003341 46311 None 0 Human Functional pEC50 = 6.6 6.6 -10 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 376 10 4 4 3.5 C[C@H](CNc1ccc(CCC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
CHEMBL153558 46311 None 0 Human Functional pEC50 = 6.6 6.6 -10 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 376 10 4 4 3.5 C[C@H](CNc1ccc(CCC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
56658246 64518 None 0 Human Functional pEC50 = 6.6 6.6 -1258 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 525 17 5 8 2.9 O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
CHEMBL1814277 64518 None 0 Human Functional pEC50 = 6.6 6.6 -1258 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 525 17 5 8 2.9 O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
CHEMBL1814278 64518 None 0 Human Functional pEC50 = 6.6 6.6 -1258 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 525 17 5 8 2.9 O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
11003341 46311 None 0 Human Functional pEC50 = 6.6 6.6 -10 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 376 10 4 4 3.5 C[C@H](CNc1ccc(CCC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL153558 46311 None 0 Human Functional pEC50 = 6.6 6.6 -10 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 376 10 4 4 3.5 C[C@H](CNc1ccc(CCC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
2419 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
5152 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
5152.0 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
559 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
CHEMBL1263 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
DB00938 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
42625511 12741 None 0 Human Functional pEC50 = 6.6 6.6 -316 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1 10.1021/jm801016j
CHEMBL1187778 12741 None 0 Human Functional pEC50 = 6.6 6.6 -316 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1 10.1021/jm801016j
CHEMBL520313 12741 None 0 Human Functional pEC50 = 6.6 6.6 -316 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccccc1CCCCOCCCCCCNC[C@H](O)c1ccc(O)c(CO)c1 10.1021/jm801016j
2419 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.069
5152 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.069
5152.0 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.069
559 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.069
CHEMBL1263 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.069
DB00938 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.069
2419 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.11.072
5152 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.11.072
5152.0 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.11.072
559 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.11.072
CHEMBL1263 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.11.072
DB00938 3463 None 53 Human Functional pEC50 = 6.6 6.6 -977 19
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.11.072
10180590 70255 None 0 Human Functional pEC50 = 6.6 6.6 -707 2
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 422 11 6 6 2.9 OCc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.11.072
CHEMBL1940830 70255 None 0 Human Functional pEC50 = 6.6 6.6 -707 2
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 422 11 6 6 2.9 OCc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.11.072
10202462 70256 None 0 Human Functional pEC50 = 6.6 6.6 -223 2
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 422 11 6 6 2.9 OCc1cc([C@@H](O)CNCCc2ccc(NC[C@@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.11.072
CHEMBL1940831 70256 None 0 Human Functional pEC50 = 6.6 6.6 -223 2
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 422 11 6 6 2.9 OCc1cc([C@@H](O)CNCCc2ccc(NC[C@@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.11.072
11669967 76547 None 0 Human Functional pEC50 = 5.6 5.6 -12589 2
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 468 10 5 5 4.5 C[C@H](CNc1cccc(-c2ccc(C(=O)O)cc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
CHEMBL206002 76547 None 0 Human Functional pEC50 = 5.6 5.6 -12589 2
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 468 10 5 5 4.5 C[C@H](CNc1cccc(-c2ccc(C(=O)O)cc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
45375919 199467 None 0 Human Functional pEC50 = 6.6 6.6 -87 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 400 7 5 6 2.1 CC(C)(Cc1cccc(C(=O)O)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL566973 199467 None 0 Human Functional pEC50 = 6.6 6.6 -87 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 400 7 5 6 2.1 CC(C)(Cc1cccc(C(=O)O)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
10232096 107721 None 0 Human Functional pEC50 = 6.6 6.6 -1 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 586 12 5 6 5.1 O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL319041 107721 None 0 Human Functional pEC50 = 6.6 6.6 -1 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 586 12 5 6 5.1 O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
44396530 67109 None 0 Human Functional pEC50 = 7.6 7.6 -23 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 591 14 4 8 4.8 CCCCS(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12 10.1016/j.bmcl.2004.10.035
CHEMBL187317 67109 None 0 Human Functional pEC50 = 7.6 7.6 -23 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 591 14 4 8 4.8 CCCCS(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12 10.1016/j.bmcl.2004.10.035
44396798 169495 None 0 Human Functional pEC50 = 7.6 7.6 -56 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 542 10 5 7 3.2 C[C@H](Cc1c[nH]c2c(S(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccc(N)c2)c1 10.1016/j.bmcl.2004.09.054
CHEMBL442225 169495 None 0 Human Functional pEC50 = 7.6 7.6 -56 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 542 10 5 7 3.2 C[C@H](Cc1c[nH]c2c(S(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccc(N)c2)c1 10.1016/j.bmcl.2004.09.054
45483846 199267 None 0 Human Functional pEC50 = 7.6 7.6 -1 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 412 6 4 5 3.7 CC(C)(Cc1ccc(C(C)(C)C)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL565685 199267 None 0 Human Functional pEC50 = 7.6 7.6 -1 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 412 6 4 5 3.7 CC(C)(Cc1ccc(C(C)(C)C)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
44574868 178679 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 534 13 3 6 4.8 O=C(Cc1nccn1Cc1ccc2ccccc2c1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL467103 178679 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 534 13 3 6 4.8 O=C(Cc1nccn1Cc1ccc2ccccc2c1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
24823131 97455 None 0 Human Functional pEC50 = 6.6 6.6 -15 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 429 8 3 3 5.2 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1Cl 10.1021/jm701324c
CHEMBL269823 97455 None 0 Human Functional pEC50 = 6.6 6.6 -15 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 429 8 3 3 5.2 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1Cl 10.1021/jm701324c
24823294 159161 None 0 Human Functional pEC50 = 6.6 6.6 -870 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 459 10 3 4 5.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1 10.1021/jm701324c
CHEMBL409718 159161 None 0 Human Functional pEC50 = 6.6 6.6 -870 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 459 10 3 4 5.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1 10.1021/jm701324c
44127374 198690 None 0 Human Functional pEC50 = 6.6 6.6 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 421 11 4 6 2.5 O=C(Cc1ccncc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL561693 198690 None 0 Human Functional pEC50 = 6.6 6.6 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 421 11 4 6 2.5 O=C(Cc1ccncc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
24823294 159161 None 0 Human Functional pEC50 = 6.6 6.6 -870 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 459 10 3 4 5.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1 10.1021/jm8000345
CHEMBL409718 159161 None 0 Human Functional pEC50 = 6.6 6.6 -870 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 459 10 3 4 5.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1 10.1021/jm8000345
11420551 12523 None 0 Human Functional pEC50 = 6.6 6.6 -436 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 495 11 4 6 3.7 CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL1186589 12523 None 0 Human Functional pEC50 = 6.6 6.6 -436 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 495 11 4 6 3.7 CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL471060 12523 None 0 Human Functional pEC50 = 6.6 6.6 -436 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 495 11 4 6 3.7 CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
24823294 159161 None 0 Human Functional pEC50 = 6.6 6.6 -870 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 459 10 3 4 5.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1 10.1021/jm9000709
CHEMBL409718 159161 None 0 Human Functional pEC50 = 6.6 6.6 -870 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 459 10 3 4 5.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1 10.1021/jm9000709
1028 291 None 40 Guinea pig Functional pEC50 = 6.6 6.6 -6 19
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
139148732 291 None 40 Guinea pig Functional pEC50 = 6.6 6.6 -6 19
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
479 291 None 40 Guinea pig Functional pEC50 = 6.6 6.6 -6 19
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
5816 291 None 40 Guinea pig Functional pEC50 = 6.6 6.6 -6 19
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
5816.0 291 None 40 Guinea pig Functional pEC50 = 6.6 6.6 -6 19
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
CHEMBL679 291 None 40 Guinea pig Functional pEC50 = 6.6 6.6 -6 19
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
DB00668 291 None 40 Guinea pig Functional pEC50 = 6.6 6.6 -6 19
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
10119515 108445 None 0 Human Functional pEC50 = 6.6 6.6 -7 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 536 12 5 6 3.9 O=C(NCc1ccccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL319840 108445 None 0 Human Functional pEC50 = 6.6 6.6 -7 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 536 12 5 6 3.9 O=C(NCc1ccccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
11758172 100988 None 0 Human Functional pEC50 = 5.6 5.6 -181 3
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.
ChEMBL 592 11 3 7 5.8 O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(F)c(F)c3)cs2)cc1 10.1021/jm000286i
CHEMBL293994 100988 None 0 Human Functional pEC50 = 5.6 5.6 -181 3
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.
ChEMBL 592 11 3 7 5.8 O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(F)c(F)c3)cs2)cc1 10.1021/jm000286i
44336319 6365 None 0 Human Functional pEC50 = 5.6 5.6 -524 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 617 12 6 7 3.7 CS(=O)(=O)Nc1cc([C@@H](O)CNCCc2ccc(NC3CCN(C(=O)NCc4cc(F)ccc4F)CC3)cc2)ccc1O 10.1016/s0960-894x(01)00645-x
CHEMBL108214 6365 None 0 Human Functional pEC50 = 5.6 5.6 -524 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 617 12 6 7 3.7 CS(=O)(=O)Nc1cc([C@@H](O)CNCCc2ccc(NC3CCN(C(=O)NCc4cc(F)ccc4F)CC3)cc2)ccc1O 10.1016/s0960-894x(01)00645-x
46232973 203244 None 0 Human Functional pEC50 = 7.6 7.6 -19 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 424 6 4 5 3.4 CC(C)(Cc1ccccc1C(F)(F)F)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL600617 203244 None 0 Human Functional pEC50 = 7.6 7.6 -19 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 424 6 4 5 3.4 CC(C)(Cc1ccccc1C(F)(F)F)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
44392255 166056 None 0 Human Functional pEC50 = 7.6 7.6 -5 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 401 11 5 5 2.1 CC(C)NC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
CHEMBL425173 166056 None 0 Human Functional pEC50 = 7.6 7.6 -5 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 401 11 5 5 2.1 CC(C)NC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
44574827 178737 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 518 13 3 6 4.3 O=C(Cc1nccn1Cc1ccc(Cl)cc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL467502 178737 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 518 13 3 6 4.3 O=C(Cc1nccn1Cc1ccc(Cl)cc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
24950401 177130 None 0 Human Functional pEC50 = 6.6 6.6 -147 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 481 8 3 6 4.5 CN(C)c1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)cc(C(=O)O)c1 10.1021/jm800222k
CHEMBL463181 177130 None 0 Human Functional pEC50 = 6.6 6.6 -147 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 481 8 3 6 4.5 CN(C)c1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)nc2)CC3)cc(C(=O)O)c1 10.1021/jm800222k
44127171 178623 None 0 Human Functional pEC50 = 5.6 5.6 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 421 11 4 6 2.5 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL466705 178623 None 0 Human Functional pEC50 = 5.6 5.6 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 421 11 4 6 2.5 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
10722793 113410 None 0 Human Functional pEC50 = 5.6 5.6 -407 3
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.
ChEMBL 640 12 3 8 6.4 O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(OC(F)(F)F)cc3)cs2)cc1 10.1021/jm000286i
CHEMBL331744 113410 None 0 Human Functional pEC50 = 5.6 5.6 -407 3
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.
ChEMBL 640 12 3 8 6.4 O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(OC(F)(F)F)cc3)cs2)cc1 10.1021/jm000286i
9871800 56504 None 0 Human Functional pEC50 = 5.6 5.6 -269 3
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 534 9 5 9 2.0 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(CC4SC(=O)NC4=O)cc3)CC2)ccc1O 10.1016/s0960-894x(01)00063-4
CHEMBL163262 56504 None 0 Human Functional pEC50 = 5.6 5.6 -269 3
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 534 9 5 9 2.0 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(CC4SC(=O)NC4=O)cc3)CC2)ccc1O 10.1016/s0960-894x(01)00063-4
46232974 203265 None 8 Human Functional pEC50 = 5.6 5.6 -27 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(CC(C)(C)NC[C@@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.12.087
CHEMBL600817 203265 None 8 Human Functional pEC50 = 5.6 5.6 -27 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(CC(C)(C)NC[C@@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.12.087
46233013 203761 None 0 Human Functional pEC50 = 6.6 6.6 -19 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1cccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1 10.1016/j.bmcl.2009.12.087
CHEMBL604125 203761 None 0 Human Functional pEC50 = 6.6 6.6 -19 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1cccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1 10.1016/j.bmcl.2009.12.087
45484538 14102 None 0 Human Functional pEC50 = 7.6 7.6 -2 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 556 13 6 7 1.9 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL1197779 14102 None 0 Human Functional pEC50 = 7.6 7.6 -2 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 556 13 6 7 1.9 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL585382 14102 None 0 Human Functional pEC50 = 7.6 7.6 -2 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 556 13 6 7 1.9 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
44579651 187262 None 0 Human Functional pEC50 = 7.6 7.6 -14 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 425 9 3 4 5.1 C[C@H](Cc1cccc(Oc2cccc(C(=O)O)c2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2008.08.009
CHEMBL492006 187262 None 0 Human Functional pEC50 = 7.6 7.6 -14 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 425 9 3 4 5.1 C[C@H](Cc1cccc(Oc2cccc(C(=O)O)c2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2008.08.009
24894202 189133 None 0 Human Functional pEC50 = 7.6 7.6 -676 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 473 10 3 4 6.0 C[C@H](Cc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1)NC[C@H](O)c1ccccc1 10.1021/jm8000345
CHEMBL509156 189133 None 0 Human Functional pEC50 = 7.6 7.6 -676 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 473 10 3 4 6.0 C[C@H](Cc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1)NC[C@H](O)c1ccccc1 10.1021/jm8000345
44574688 178593 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 461 11 5 6 2.0 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]c(=O)[nH]c23)cc1 10.1016/j.bmc.2009.03.044
CHEMBL466519 178593 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 461 11 5 6 2.0 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]c(=O)[nH]c23)cc1 10.1016/j.bmc.2009.03.044
44574722 178657 None 0 Human Functional pEC50 = 6.6 6.6 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 433 11 3 5 3.5 Cc1cc(C)nc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1 10.1016/j.bmc.2009.03.044
CHEMBL466925 178657 None 0 Human Functional pEC50 = 6.6 6.6 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 433 11 3 5 3.5 Cc1cc(C)nc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1 10.1016/j.bmc.2009.03.044
44219630 178680 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 498 13 2 6 3.7 CN(C(=O)Cc1nccn1Cc1ccccc1)c1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL467116 178680 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 498 13 2 6 3.7 CN(C(=O)Cc1nccn1Cc1ccccc1)c1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
24822310 97794 None 0 Human Functional pEC50 = 6.6 6.6 -41 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 395 8 3 3 4.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
CHEMBL271576 97794 None 0 Human Functional pEC50 = 6.6 6.6 -41 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 395 8 3 3 4.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
24822310 97794 None 0 Human Functional pEC50 = 6.6 6.6 -41 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 395 8 3 3 4.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1016/j.bmcl.2008.08.009
CHEMBL271576 97794 None 0 Human Functional pEC50 = 6.6 6.6 -41 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 395 8 3 3 4.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1016/j.bmcl.2008.08.009
44127054 197742 None 0 Human Functional pEC50 = 6.6 6.6 6 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 450 12 4 6 3.2 COc1ccc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL551350 197742 None 0 Human Functional pEC50 = 6.6 6.6 6 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 450 12 4 6 3.2 COc1ccc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)cc1 10.1016/j.ejmech.2009.01.022
24822310 97794 None 0 Human Functional pEC50 = 6.6 6.6 -41 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 395 8 3 3 4.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm800222k
CHEMBL271576 97794 None 0 Human Functional pEC50 = 6.6 6.6 -41 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 395 8 3 3 4.6 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm800222k
24895365 173696 None 0 Human Functional pEC50 = 6.6 6.6 -309 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 447 10 3 4 5.5 CC(C)Oc1cc(-c2ccc(CC(C)(C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL453323 173696 None 0 Human Functional pEC50 = 6.6 6.6 -309 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 447 10 3 4 5.5 CC(C)Oc1cc(-c2ccc(CC(C)(C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
10298968 57523 None 0 Human Functional pEC50 = 5.5 5.5 -239 2
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 471 9 4 8 2.3 O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)COc4ccc(O)cc4)CC3)cc2)S1 10.1016/s0960-894x(01)00063-4
CHEMBL166085 57523 None 0 Human Functional pEC50 = 5.5 5.5 -239 2
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 471 9 4 8 2.3 O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)COc4ccc(O)cc4)CC3)cc2)S1 10.1016/s0960-894x(01)00063-4
44396596 123367 None 0 Human Functional pEC50 = 7.5 7.5 -25 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 485 10 4 6 4.3 COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12 10.1016/j.bmcl.2004.10.035
CHEMBL361505 123367 None 0 Human Functional pEC50 = 7.5 7.5 -25 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 485 10 4 6 4.3 COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12 10.1016/j.bmcl.2004.10.035
44396521 123747 None 0 Human Functional pEC50 = 7.5 7.5 -6 2
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 514 12 5 7 3.6 C[C@H](Cc1c[nH]c2c(OCCN)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
CHEMBL362136 123747 None 0 Human Functional pEC50 = 7.5 7.5 -6 2
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 514 12 5 7 3.6 C[C@H](Cc1c[nH]c2c(OCCN)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
44127171 178623 None 0 Human Functional pEC50 = 6.5 6.5 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 421 11 4 6 2.5 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL466705 178623 None 0 Human Functional pEC50 = 6.5 6.5 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 421 11 4 6 2.5 O=C(Cc1ccccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.bmc.2009.03.044
1028 291 None 40 Human Functional pEC50 = 6.5 6.5 -10 19
Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/acs.jnatprod.9b00418
139148732 291 None 40 Human Functional pEC50 = 6.5 6.5 -10 19
Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/acs.jnatprod.9b00418
479 291 None 40 Human Functional pEC50 = 6.5 6.5 -10 19
Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/acs.jnatprod.9b00418
5816 291 None 40 Human Functional pEC50 = 6.5 6.5 -10 19
Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/acs.jnatprod.9b00418
5816.0 291 None 40 Human Functional pEC50 = 6.5 6.5 -10 19
Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/acs.jnatprod.9b00418
CHEMBL679 291 None 40 Human Functional pEC50 = 6.5 6.5 -10 19
Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/acs.jnatprod.9b00418
DB00668 291 None 40 Human Functional pEC50 = 6.5 6.5 -10 19
Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assayAgonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/acs.jnatprod.9b00418
45101537 197730 None 0 Human Functional pEC50 = 6.5 6.5 -1819 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
ChEMBL 526 11 4 7 3.8 CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccc(O)cc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1016/j.bmcl.2009.06.083
CHEMBL551272 197730 None 0 Human Functional pEC50 = 6.5 6.5 -1819 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
ChEMBL 526 11 4 7 3.8 CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccc(O)cc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1016/j.bmcl.2009.06.083
45483830 199451 None 0 Human Functional pEC50 = 6.5 6.5 -14 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 329 7 4 4 2.8 Cc1ccccc1CC(C)(C)NCC(O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2009.10.013
CHEMBL566777 199451 None 0 Human Functional pEC50 = 6.5 6.5 -14 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 329 7 4 4 2.8 Cc1ccccc1CC(C)(C)NCC(O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2009.10.013
44237720 58255 None 0 Rat Functional pEC50 = 6.5 6.5 -91 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 530 9 6 5 4.4 O=C(NCC12CC3CC(CC(C3)C1)C2)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682220 58255 None 0 Rat Functional pEC50 = 6.5 6.5 -91 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 530 9 6 5 4.4 O=C(NCC12CC3CC(CC(C3)C1)C2)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
145983355 165896 None 0 Human Functional pEC50 = 6.5 6.5 -26 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 454 12 3 5 3.6 CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NS(=O)(=O)c2ccccc2)cc1 10.1016/j.ejmech.2018.03.032
CHEMBL4248093 165896 None 0 Human Functional pEC50 = 6.5 6.5 -26 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 454 12 3 5 3.6 CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NS(=O)(=O)c2ccccc2)cc1 10.1016/j.ejmech.2018.03.032
44268273 97133 None 0 Human Functional pEC50 = 8.5 8.5 1 3
Agonist activity against cloned human beta-1 adrenergic receptor as percent activation of adenyl cyclase activity at a concentration of 1000 nMAgonist activity against cloned human beta-1 adrenergic receptor as percent activation of adenyl cyclase activity at a concentration of 1000 nM
ChEMBL 476 11 4 6 3.4 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1Cl 10.1016/s0960-894x(98)00169-3
CHEMBL267306 97133 None 0 Human Functional pEC50 = 8.5 8.5 1 3
Agonist activity against cloned human beta-1 adrenergic receptor as percent activation of adenyl cyclase activity at a concentration of 1000 nMAgonist activity against cloned human beta-1 adrenergic receptor as percent activation of adenyl cyclase activity at a concentration of 1000 nM
ChEMBL 476 11 4 6 3.4 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1Cl 10.1016/s0960-894x(98)00169-3
44392190 65604 None 0 Human Functional pEC50 = 8.5 8.5 4 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 421 10 5 5 3.2 O=C(Nc1ccccc1)Nc1ccc(C[C@H](O)NC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
CHEMBL183211 65604 None 0 Human Functional pEC50 = 8.5 8.5 4 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 421 10 5 5 3.2 O=C(Nc1ccccc1)Nc1ccc(C[C@H](O)NC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
9896742 207402 None 0 Human Functional pEC50 = 8.5 8.5 -13 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR) at a concentration of 10000 nmCompound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR) at a concentration of 10000 nm
ChEMBL 618 12 6 7 6.0 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc3cc(OCC4NCCc5cc(O)c(O)cc54)ccc3c2)cc1 10.1016/s0960-894x(00)00459-5
CHEMBL76403 207402 None 0 Human Functional pEC50 = 8.5 8.5 -13 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR) at a concentration of 10000 nmCompound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR) at a concentration of 10000 nm
ChEMBL 618 12 6 7 6.0 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc3cc(OCC4NCCc5cc(O)c(O)cc54)ccc3c2)cc1 10.1016/s0960-894x(00)00459-5
66653268 88285 None 0 Human Functional pEC50 = 8.5 8.5 3311 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 491 14 4 6 3.8 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1cccc(Cl)c1 10.1021/jm400348g
CHEMBL2348201 88285 None 0 Human Functional pEC50 = 8.5 8.5 3311 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 491 14 4 6 3.8 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1cccc(Cl)c1 10.1021/jm400348g
164622954 188673 None 0 Human Functional pEC50 = 8.5 8.5 -245 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4871708 188673 None 0 Human Functional pEC50 = 8.5 8.5 -245 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028726 188673 None 0 Human Functional pEC50 = 8.5 8.5 -245 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164624634 188692 None 0 Human Functional pEC50 = 8.5 8.5 -131 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868684 188692 None 0 Human Functional pEC50 = 8.5 8.5 -131 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028836 188692 None 0 Human Functional pEC50 = 8.5 8.5 -131 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
24822971 95501 None 0 Human Functional pEC50 = 8.5 8.5 3 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 429 8 3 3 5.2 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2Cl)cc1 10.1021/jm701324c
CHEMBL257106 95501 None 0 Human Functional pEC50 = 8.5 8.5 3 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 429 8 3 3 5.2 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2Cl)cc1 10.1021/jm701324c
11134054 46997 None 0 Human Functional pEC50 = 8.5 8.5 -2 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 444 10 4 6 4.1 C[C@H](CNc1ccc(CC(=O)Nc2nccs2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
CHEMBL154150 46997 None 0 Human Functional pEC50 = 8.5 8.5 -2 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 444 10 4 6 4.1 C[C@H](CNc1ccc(CC(=O)Nc2nccs2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
1499 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
1499 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
3779 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
3779 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
3779.0 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
3779.0 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
536 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
536 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
CHEMBL434 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
CHEMBL434 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
DB01064 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
DB01064 2091 None 34 Human Functional pEC50 = 8.5 8.5 -58 38
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
45484583 200948 None 0 Human Functional pEC50 = 8.5 8.5 -3 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 456 10 6 7 2.0 CC(C)(Cc1ccc(NC(=O)CCCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL577702 200948 None 0 Human Functional pEC50 = 8.5 8.5 -3 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 456 10 6 7 2.0 CC(C)(Cc1ccc(NC(=O)CCCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
45484585 14103 None 0 Human Functional pEC50 = 8.5 8.5 -3 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 556 13 6 7 1.9 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL1197807 14103 None 0 Human Functional pEC50 = 8.5 8.5 -3 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 556 13 6 7 1.9 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL587197 14103 None 0 Human Functional pEC50 = 8.5 8.5 -3 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 556 13 6 7 1.9 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)C[N+](C)(C)C)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
24936626 17416 None 0 Human Functional pEC50 = 8.5 8.5 -173 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 506 9 4 9 3.6 OCc1cc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)ccc1O 10.1016/j.bmcl.2010.08.039
CHEMBL1257555 17416 None 0 Human Functional pEC50 = 8.5 8.5 -173 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 506 9 4 9 3.6 OCc1cc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)ccc1O 10.1016/j.bmcl.2010.08.039
45483814 199728 None 0 Human Functional pEC50 = 8.4 8.4 -5 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 440 7 4 6 3.3 CC(C)(Cc1ccc(OC(F)(F)F)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL568531 199728 None 0 Human Functional pEC50 = 8.4 8.4 -5 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 440 7 4 6 3.3 CC(C)(Cc1ccc(OC(F)(F)F)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
44392212 168472 None 0 Human Functional pEC50 = 8.4 8.4 12 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 405 10 4 4 3.9 O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
CHEMBL1204383 168472 None 0 Human Functional pEC50 = 8.4 8.4 12 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 405 10 4 4 3.9 O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
CHEMBL434524 168472 None 0 Human Functional pEC50 = 8.4 8.4 12 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 405 10 4 4 3.9 O=C(Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
56597179 88303 None 0 Human Functional pEC50 = 8.4 8.4 2754 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 473 14 5 7 2.9 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
CHEMBL2348219 88303 None 0 Human Functional pEC50 = 8.4 8.4 2754 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 473 14 5 7 2.9 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
45483868 199678 None 0 Human Functional pEC50 = 8.4 8.4 -6 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 424 6 4 5 3.4 CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL568273 199678 None 0 Human Functional pEC50 = 8.4 8.4 -6 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 424 6 4 5 3.4 CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
45483864 201365 None 0 Human Functional pEC50 = 8.4 8.4 -9 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 424 6 4 5 3.4 CC(C)(Cc1ccc(C(F)(F)F)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL584498 201365 None 0 Human Functional pEC50 = 8.4 8.4 -9 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 424 6 4 5 3.4 CC(C)(Cc1ccc(C(F)(F)F)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
24823624 159254 None 0 Human Functional pEC50 = 8.4 8.4 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 410 9 4 4 4.6 O=C(O)c1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
CHEMBL409827 159254 None 0 Human Functional pEC50 = 8.4 8.4 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 410 9 4 4 4.6 O=C(O)c1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
16049028 64106 None 0 Human Functional pEC50 = 8.4 8.4 -50 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 462 14 4 7 3.7 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807819 64106 None 0 Human Functional pEC50 = 8.4 8.4 -50 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 462 14 4 7 3.7 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1 10.1016/j.bmcl.2011.05.097
11592062 112520 None 0 Human Functional pEC50 = 8.4 8.4 -25 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1 10.1016/j.bmcl.2014.04.095
CHEMBL3298325 112520 None 0 Human Functional pEC50 = 8.4 8.4 -25 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1 10.1016/j.bmcl.2014.04.095
24822645 95546 None 0 Human Functional pEC50 = 7.5 7.5 -15 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 429 8 3 3 5.2 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c(Cl)c1 10.1021/jm701324c
CHEMBL257297 95546 None 0 Human Functional pEC50 = 7.5 7.5 -15 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 429 8 3 3 5.2 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c(Cl)c1 10.1021/jm701324c
45269866 197750 None 0 Human Functional pEC50 = 7.5 7.5 1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 455 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Cl)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL2448072 197750 None 0 Human Functional pEC50 = 7.5 7.5 1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 455 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Cl)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL551389 197750 None 0 Human Functional pEC50 = 7.5 7.5 1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 455 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Cl)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
45269025 198603 None 0 Human Functional pEC50 = 7.5 7.5 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 500 11 5 6 2.7 NS(=O)(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1203991 198603 None 0 Human Functional pEC50 = 7.5 7.5 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 500 11 5 6 2.7 NS(=O)(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL561173 198603 None 0 Human Functional pEC50 = 7.5 7.5 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 500 11 5 6 2.7 NS(=O)(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
45267257 199138 None 0 Human Functional pEC50 = 7.5 7.5 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 449 12 4 4 3.8 O[C@@H](CNCCc1ccc(NC(=S)NCCc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1203987 199138 None 0 Human Functional pEC50 = 7.5 7.5 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 449 12 4 4 3.8 O[C@@H](CNCCc1ccc(NC(=S)NCCc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL564648 199138 None 0 Human Functional pEC50 = 7.5 7.5 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 449 12 4 4 3.8 O[C@@H](CNCCc1ccc(NC(=S)NCCc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
10283146 107329 None 0 Human Functional pEC50 = 7.5 7.5 -2 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 656 12 5 9 3.1 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4cc(CC(=O)O)c5ccccc54)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
CHEMBL317003 107329 None 0 Human Functional pEC50 = 7.5 7.5 -2 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 656 12 5 9 3.1 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4cc(CC(=O)O)c5ccccc54)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
1960 2857 None 46 Guinea pig Functional pEC50 = 7.5 7.5 -37 18
Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
439260 2857 None 46 Guinea pig Functional pEC50 = 7.5 7.5 -37 18
Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
439260.0 2857 None 46 Guinea pig Functional pEC50 = 7.5 7.5 -37 18
Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
505 2857 None 46 Guinea pig Functional pEC50 = 7.5 7.5 -37 18
Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
CHEMBL1437 2857 None 46 Guinea pig Functional pEC50 = 7.5 7.5 -37 18
Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
DB00368 2857 None 46 Guinea pig Functional pEC50 = 7.5 7.5 -37 18
Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum.
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
164623583 188683 None 0 Human Functional pEC50 = 7.5 7.5 -316 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4873280 188683 None 0 Human Functional pEC50 = 7.5 7.5 -316 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028767 188683 None 0 Human Functional pEC50 = 7.5 7.5 -316 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
24822970 158212 None 0 Human Functional pEC50 = 6.5 6.5 -9 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 409 9 3 3 4.5 O=C(O)Cc1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
CHEMBL408694 158212 None 0 Human Functional pEC50 = 6.5 6.5 -9 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 409 9 3 3 4.5 O=C(O)Cc1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
11224220 173070 None 0 Human Functional pEC50 = 6.5 6.5 -2137 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 431 10 3 3 5.5 CC(C)Cc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL451760 173070 None 0 Human Functional pEC50 = 6.5 6.5 -2137 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 431 10 3 3 5.5 CC(C)Cc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
172745 100177 None 2 Guinea pig Functional pEC50 = 6.5 6.5 234 2
Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations
ChEMBL 187 2 4 4 0.2 NCC(O)c1ccc(O)c(O)c1F 10.1021/jm00118a019
CHEMBL287587 100177 None 2 Guinea pig Functional pEC50 = 6.5 6.5 234 2
Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations
ChEMBL 187 2 4 4 0.2 NCC(O)c1ccc(O)c(O)c1F 10.1021/jm00118a019
44268268 18658 None 1 Human Functional pEC50 = 6.5 6.5 -301 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 493 11 4 7 3.3 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1cnc2ccccc2c1 10.1016/s0960-894x(98)00169-3
CHEMBL12769 18658 None 1 Human Functional pEC50 = 6.5 6.5 -301 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 493 11 4 7 3.3 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1cnc2ccccc2c1 10.1016/s0960-894x(98)00169-3
172462257 196705 None 0 Human Functional pEC50 = 6.5 6.5 -2 3
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 459 10 2 5 5.0 CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1 10.1016/j.ejmech.2022.114961
CHEMBL5430355 196705 None 0 Human Functional pEC50 = 6.5 6.5 -2 3
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 459 10 2 5 5.0 CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1 10.1016/j.ejmech.2022.114961
172446785 195127 None 0 Human Functional pEC50 = 6.5 6.5 -2 3
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 389 11 2 3 4.8 CCc1ccccc1OC[C@@H](O)CNCCC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2022.114961
CHEMBL5397120 195127 None 0 Human Functional pEC50 = 6.5 6.5 -2 3
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 389 11 2 3 4.8 CCc1ccccc1OC[C@@H](O)CNCCC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2022.114961
16049377 64119 None 0 Human Functional pEC50 = 7.5 7.5 -112 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 465 13 5 7 2.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCOCCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807832 64119 None 0 Human Functional pEC50 = 7.5 7.5 -112 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 465 13 5 7 2.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCOCCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
56665368 66480 None 0 Human Functional pEC50 = 7.5 7.5 -31 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 501 18 6 6 4.2 CCNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1835854 66480 None 0 Human Functional pEC50 = 7.5 7.5 -31 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 501 18 6 6 4.2 CCNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1852119 66480 None 0 Human Functional pEC50 = 7.5 7.5 -31 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 501 18 6 6 4.2 CCNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
56672271 66562 None 0 Human Functional pEC50 = 7.5 7.5 -125 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 530 19 7 7 2.7 NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1835859 66562 None 0 Human Functional pEC50 = 7.5 7.5 -125 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 530 19 7 7 2.7 NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1852407 66562 None 0 Human Functional pEC50 = 7.5 7.5 -125 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 530 19 7 7 2.7 NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
56672269 66608 None 0 Human Functional pEC50 = 7.5 7.5 -50 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 515 19 6 6 3.9 CCNC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1835858 66608 None 0 Human Functional pEC50 = 7.5 7.5 -50 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 515 19 6 6 3.9 CCNC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1852564 66608 None 0 Human Functional pEC50 = 7.5 7.5 -50 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 515 19 6 6 3.9 CCNC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
56658405 66609 None 0 Human Functional pEC50 = 7.5 7.5 -63 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 501 18 6 6 4.2 CCNC(=O)Nc1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1016/j.bmc.2011.08.043
CHEMBL1835856 66609 None 0 Human Functional pEC50 = 7.5 7.5 -63 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 501 18 6 6 4.2 CCNC(=O)Nc1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1016/j.bmc.2011.08.043
CHEMBL1852565 66609 None 0 Human Functional pEC50 = 7.5 7.5 -63 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 501 18 6 6 4.2 CCNC(=O)Nc1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1016/j.bmc.2011.08.043
46832505 14240 None 1 Human Functional pEC50 = 7.5 7.5 -12 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 417 16 4 6 3.3 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2ccccc2)ccc1O 10.1021/jm100326d
CHEMBL1085395 14240 None 1 Human Functional pEC50 = 7.5 7.5 -12 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 417 16 4 6 3.3 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2ccccc2)ccc1O 10.1021/jm100326d
CHEMBL1199261 14240 None 1 Human Functional pEC50 = 7.5 7.5 -12 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 417 16 4 6 3.3 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2ccccc2)ccc1O 10.1021/jm100326d
46889854 7310 None 0 Human Functional pEC50 = 6.5 6.5 -9 3
Agonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayAgonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 7 2 4 4.8 O=C(c1ccc(F)cc1)C1CCN(CC(O)COc2cccc3[nH]c4ccccc4c23)CC1 10.1016/j.bmcl.2010.04.009
CHEMBL1086077 7310 None 0 Human Functional pEC50 = 6.5 6.5 -9 3
Agonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayAgonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 7 2 4 4.8 O=C(c1ccc(F)cc1)C1CCN(CC(O)COc2cccc3[nH]c4ccccc4c23)CC1 10.1016/j.bmcl.2010.04.009
24949728 175344 None 0 Human Functional pEC50 = 6.5 6.5 -436 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 479 8 3 4 5.7 CC(C)Oc1cc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)ccc1C(=O)O 10.1021/jm800222k
CHEMBL457199 175344 None 0 Human Functional pEC50 = 6.5 6.5 -436 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 479 8 3 4 5.7 CC(C)Oc1cc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)ccc1C(=O)O 10.1021/jm800222k
44127679 197918 None 0 Human Functional pEC50 = 5.5 5.5 -37 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 422 11 4 7 1.9 O=C(Cc1cnccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL552497 197918 None 0 Human Functional pEC50 = 5.5 5.5 -37 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 422 11 4 7 1.9 O=C(Cc1cnccn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
172454272 196013 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 359 7 2 7 1.6 O[C@@H](CNCC1COc2ccccc2O1)COc1ccc2c(c1)OCO2 10.1016/j.ejmech.2022.114961
CHEMBL5415148 196013 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 359 7 2 7 1.6 O[C@@H](CNCC1COc2ccccc2O1)COc1ccc2c(c1)OCO2 10.1016/j.ejmech.2022.114961
9891927 184303 None 9 Human Functional pEC50 = 6.5 6.5 -1995 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL446840 184303 None 9 Human Functional pEC50 = 6.5 6.5 -1995 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL483200 184303 None 9 Human Functional pEC50 = 6.5 6.5 -1995 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL483201 184303 None 9 Human Functional pEC50 = 6.5 6.5 -1995 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
9891927 184303 None 9 Human Functional pEC50 = 6.5 6.5 -1995 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL446840 184303 None 9 Human Functional pEC50 = 6.5 6.5 -1995 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL483200 184303 None 9 Human Functional pEC50 = 6.5 6.5 -1995 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL483201 184303 None 9 Human Functional pEC50 = 6.5 6.5 -1995 4
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
44331302 210787 None 0 Human Functional pEC50 = 5.5 5.5 -630 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 667 12 6 8 3.1 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
CHEMBL99219 210787 None 0 Human Functional pEC50 = 5.5 5.5 -630 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 667 12 6 8 3.1 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
11661536 76003 None 0 Human Functional pEC50 = 5.5 5.5 -50 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 411 9 4 5 3.8 O=C(O)c1cncc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)c1 10.1021/jm0509445
CHEMBL205389 76003 None 0 Human Functional pEC50 = 5.5 5.5 -50 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 411 9 4 5 3.8 O=C(O)c1cncc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)c1 10.1021/jm0509445
145987415 167344 None 0 Human Functional pEC50 = 5.5 5.5 -1258 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 358 6 4 4 2.8 O=c1ccc2c(C(CO)NCCc3cccc(Cl)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2018.04.041
CHEMBL4292648 167344 None 0 Human Functional pEC50 = 5.5 5.5 -1258 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 358 6 4 4 2.8 O=c1ccc2c(C(CO)NCCc3cccc(Cl)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2018.04.041
24895192 189973 None 0 Human Functional pEC50 = 6.5 6.5 -151 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 437 10 3 4 4.8 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(F)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL516804 189973 None 0 Human Functional pEC50 = 6.5 6.5 -151 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 437 10 3 4 4.8 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(F)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
42639969 12576 None 0 Human Functional pEC50 = 6.5 6.5 -1584 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 496 11 4 7 3.1 CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL1186809 12576 None 0 Human Functional pEC50 = 6.5 6.5 -1584 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 496 11 4 7 3.1 CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL479530 12576 None 0 Human Functional pEC50 = 6.5 6.5 -1584 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 496 11 4 7 3.1 CC(C)Nc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
16118894 2243 None 7 Human Functional pEC50 = 6.5 6.5 -147 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 568 11 4 6 3.4 O[C@H](COc1ccc(cc1)O)CNCCc1ccc(cc1)NS(=O)(=O)c1ccc(cc1)I 10.1016/s0960-894x(98)00169-3
3467 2243 None 7 Human Functional pEC50 = 6.5 6.5 -147 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 568 11 4 6 3.4 O[C@H](COc1ccc(cc1)O)CNCCc1ccc(cc1)NS(=O)(=O)c1ccc(cc1)I 10.1016/s0960-894x(98)00169-3
CHEMBL276257 2243 None 7 Human Functional pEC50 = 6.5 6.5 -147 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 568 11 4 6 3.4 O[C@H](COc1ccc(cc1)O)CNCCc1ccc(cc1)NS(=O)(=O)c1ccc(cc1)I 10.1016/s0960-894x(98)00169-3
45483815 200898 None 0 Human Functional pEC50 = 7.5 7.5 -11 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 400 7 5 6 2.1 CC(C)(Cc1ccc(C(=O)O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL577289 200898 None 0 Human Functional pEC50 = 7.5 7.5 -11 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 400 7 5 6 2.1 CC(C)(Cc1ccc(C(=O)O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
44574721 178656 None 0 Human Functional pEC50 = 6.5 6.5 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 419 11 3 5 3.1 Cc1cccnc1CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL466924 178656 None 0 Human Functional pEC50 = 6.5 6.5 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 419 11 3 5 3.1 Cc1cccnc1CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
24950238 175058 None 0 Human Functional pEC50 = 6.5 6.5 -69 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 437 7 3 4 5.0 O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)c1 10.1021/jm800222k
CHEMBL456578 175058 None 0 Human Functional pEC50 = 6.5 6.5 -69 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 437 7 3 4 5.0 O=C(O)c1cccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)c1 10.1021/jm800222k
45270697 197626 None 0 Human Functional pEC50 = 6.5 6.5 -20 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 451 11 4 5 4.1 COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1203995 197626 None 0 Human Functional pEC50 = 6.5 6.5 -20 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 451 11 4 5 4.1 COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL550444 197626 None 0 Human Functional pEC50 = 6.5 6.5 -20 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 451 11 4 5 4.1 COc1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
24949568 189792 None 0 Human Functional pEC50 = 6.5 6.5 -338 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 536 9 4 6 5.6 O=C(O)c1cc(NC2CCOCC2)cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)c1 10.1021/jm800222k
CHEMBL515349 189792 None 0 Human Functional pEC50 = 6.5 6.5 -338 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 536 9 4 6 5.6 O=C(O)c1cc(NC2CCOCC2)cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)c1 10.1021/jm800222k
10075383 97158 None 0 Human Functional pEC50 = 6.5 6.5 -537 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 520 11 4 6 3.5 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccc(Br)cc1 10.1016/s0960-894x(98)00169-3
CHEMBL267545 97158 None 0 Human Functional pEC50 = 6.5 6.5 -537 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 520 11 4 6 3.5 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccc(Br)cc1 10.1016/s0960-894x(98)00169-3
46232768 202090 None 0 Human Functional pEC50 = 7.5 7.5 -14 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 356 6 4 5 2.4 CC(C)(Cc1ccccc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL592879 202090 None 0 Human Functional pEC50 = 7.5 7.5 -14 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 356 6 4 5 2.4 CC(C)(Cc1ccccc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
164624092 188688 None 0 Human Functional pEC50 = 7.5 7.5 -794 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 442 10 4 7 2.9 COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
CHEMBL4865514 188688 None 0 Human Functional pEC50 = 7.5 7.5 -794 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 442 10 4 7 2.9 COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
CHEMBL5028807 188688 None 0 Human Functional pEC50 = 7.5 7.5 -794 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 442 10 4 7 2.9 COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
145986105 165465 None 0 Human Functional pEC50 = 7.4 7.4 -25 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 429 10 4 4 4.0 O=C(Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1)c1ccccc1 10.1016/j.ejmech.2018.03.032
CHEMBL4237453 165465 None 0 Human Functional pEC50 = 7.4 7.4 -25 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 429 10 4 4 4.0 O=C(Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1)c1ccccc1 10.1016/j.ejmech.2018.03.032
44219641 178544 None 0 Human Functional pEC50 = 6.5 6.5 -5 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 498 13 3 6 4.1 CC(Cc1ccc(NC(=O)Cc2nccn2Cc2ccccc2)cc1)NC[C@H](O)COc1ccccc1 10.1016/j.bmc.2009.03.044
CHEMBL466088 178544 None 0 Human Functional pEC50 = 6.5 6.5 -5 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 498 13 3 6 4.1 CC(Cc1ccc(NC(=O)Cc2nccn2Cc2ccccc2)cc1)NC[C@H](O)COc1ccccc1 10.1016/j.bmc.2009.03.044
24822815 97995 None 0 Human Functional pEC50 = 6.5 6.5 -588 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 467 11 3 4 5.6 CC(C)COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm701324c
CHEMBL272583 97995 None 0 Human Functional pEC50 = 6.5 6.5 -588 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 467 11 3 4 5.6 CC(C)COc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm701324c
44127678 198758 None 0 Human Functional pEC50 = 6.5 6.5 -2 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 471 11 4 6 3.7 O=C(Cc1cc2ccccc2cn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL562153 198758 None 0 Human Functional pEC50 = 6.5 6.5 -2 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 471 11 4 6 3.7 O=C(Cc1cc2ccccc2cn1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
1960 2857 None 46 Guinea pig Functional pEC50 = 6.5 6.5 -37 18
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
439260 2857 None 46 Guinea pig Functional pEC50 = 6.5 6.5 -37 18
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
439260.0 2857 None 46 Guinea pig Functional pEC50 = 6.5 6.5 -37 18
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
505 2857 None 46 Guinea pig Functional pEC50 = 6.5 6.5 -37 18
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
CHEMBL1437 2857 None 46 Guinea pig Functional pEC50 = 6.5 6.5 -37 18
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
DB00368 2857 None 46 Guinea pig Functional pEC50 = 6.5 6.5 -37 18
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
10275157 5379 None 0 Human Functional pEC50 = 6.5 6.5 -7 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 442 10 5 6 2.2 CNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL107012 5379 None 0 Human Functional pEC50 = 6.5 6.5 -7 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 442 10 5 6 2.2 CNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
10283539 167968 None 0 Human Functional pEC50 = 6.5 6.5 -1479 3
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 697 14 6 9 2.8 CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00607-8
CHEMBL431048 167968 None 0 Human Functional pEC50 = 6.5 6.5 -1479 3
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 697 14 6 9 2.8 CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00607-8
9800339 203610 None 9 Human Functional pEC50 = 6.5 6.5 -251 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.12.087
CHEMBL603271 203610 None 9 Human Functional pEC50 = 6.5 6.5 -251 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.12.087
24823626 98099 None 0 Human Functional pEC50 = 7.4 7.4 -6 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 410 9 4 4 4.6 O=C(O)c1cccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c1 10.1021/jm701324c
CHEMBL273098 98099 None 0 Human Functional pEC50 = 7.4 7.4 -6 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 410 9 4 4 4.6 O=C(O)c1cccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c1 10.1021/jm701324c
155557083 174645 None 0 Human Functional pEC50 = 7.4 7.4 -724 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3ccc(O)cc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4556022 174645 None 0 Human Functional pEC50 = 7.4 7.4 -724 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3ccc(O)cc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
145982607 165815 None 0 Human Functional pEC50 = 7.4 7.4 -4 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 432 12 3 4 4.0 CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=O)Cc2ccccc2)cc1 10.1016/j.ejmech.2018.03.032
CHEMBL4245968 165815 None 0 Human Functional pEC50 = 7.4 7.4 -4 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 432 12 3 4 4.0 CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=O)Cc2ccccc2)cc1 10.1016/j.ejmech.2018.03.032
24949566 174976 None 1 Human Functional pEC50 = 6.4 6.4 -281 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 494 8 4 5 5.0 CC(=O)Nc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1 10.1021/jm800222k
CHEMBL456353 174976 None 1 Human Functional pEC50 = 6.4 6.4 -281 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 494 8 4 5 5.0 CC(=O)Nc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1 10.1021/jm800222k
1862 161 None 11 Guinea pig Functional pEC50 = 4.4 4.4 -9 2
Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations
ChEMBL 187 2 4 4 0.2 NCC(c1cc(O)c(cc1F)O)O 10.1021/jm00118a019
510 161 None 11 Guinea pig Functional pEC50 = 4.4 4.4 -9 2
Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations
ChEMBL 187 2 4 4 0.2 NCC(c1cc(O)c(cc1F)O)O 10.1021/jm00118a019
CHEMBL281232 161 None 11 Guinea pig Functional pEC50 = 4.4 4.4 -9 2
Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations
ChEMBL 187 2 4 4 0.2 NCC(c1cc(O)c(cc1F)O)O 10.1021/jm00118a019
24824079 12898 None 0 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 441 11 3 5 4.5 O=C(O)COc1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
CHEMBL1188934 12898 None 0 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 441 11 3 5 4.5 O=C(O)COc1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
CHEMBL537693 12898 None 0 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 441 11 3 5 4.5 O=C(O)COc1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
24895357 186401 None 0 Human Functional pEC50 = 7.4 7.4 -194 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 467 10 3 4 5.7 CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL487443 186401 None 0 Human Functional pEC50 = 7.4 7.4 -194 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 467 10 3 4 5.7 CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
42639965 12722 None 0 Human Functional pEC50 = 6.4 6.4 -691 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 534 11 3 5 5.0 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1CC1CCCCC1 10.1021/jm9000709
CHEMBL1187643 12722 None 0 Human Functional pEC50 = 6.4 6.4 -691 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 534 11 3 5 5.0 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1CC1CCCCC1 10.1021/jm9000709
CHEMBL513419 12722 None 0 Human Functional pEC50 = 6.4 6.4 -691 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 534 11 3 5 5.0 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1CC1CCCCC1 10.1021/jm9000709
44457929 84811 None 0 Human Functional pEC50 = 6.4 6.4 -114 3
Agonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclaseAgonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase
ChEMBL 593 17 3 10 3.9 CCCCCCCCn1nnn(-c2ccc(S(=O)(=O)Nc3ccc(CCNC[C@H](O)c4cccnc4)cc3)cc2)c1=O 10.1016/s0960-894x(99)00182-1
CHEMBL22318 84811 None 0 Human Functional pEC50 = 6.4 6.4 -114 3
Agonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclaseAgonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase
ChEMBL 593 17 3 10 3.9 CCCCCCCCn1nnn(-c2ccc(S(=O)(=O)Nc3ccc(CCNC[C@H](O)c4cccnc4)cc3)cc2)c1=O 10.1016/s0960-894x(99)00182-1
2419 3463 None 53 Human Functional pEC50 = 6.4 6.4 -977 19
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
5152 3463 None 53 Human Functional pEC50 = 6.4 6.4 -977 19
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
5152.0 3463 None 53 Human Functional pEC50 = 6.4 6.4 -977 19
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
559 3463 None 53 Human Functional pEC50 = 6.4 6.4 -977 19
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
CHEMBL1263 3463 None 53 Human Functional pEC50 = 6.4 6.4 -977 19
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
DB00938 3463 None 53 Human Functional pEC50 = 6.4 6.4 -977 19
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
24823130 97757 None 0 Human Functional pEC50 = 6.4 6.4 -38 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 413 8 3 3 4.7 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1F 10.1021/jm701324c
CHEMBL271367 97757 None 0 Human Functional pEC50 = 6.4 6.4 -38 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 413 8 3 3 4.7 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1F 10.1021/jm701324c
44580011 186906 None 0 Human Functional pEC50 = 6.4 6.4 -52 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 468 10 4 5 4.7 CC(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
CHEMBL489200 186906 None 0 Human Functional pEC50 = 6.4 6.4 -52 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 468 10 4 5 4.7 CC(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
10028830 2246 None 31 Human Functional pEC50 = 6.4 6.4 -186 3
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 497 13 4 6 2.7 O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1 10.1016/j.ejmech.2022.114961
3932 2246 None 31 Human Functional pEC50 = 6.4 6.4 -186 3
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 497 13 4 6 2.7 O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1 10.1016/j.ejmech.2022.114961
CHEMBL4238084 2246 None 31 Human Functional pEC50 = 6.4 6.4 -186 3
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 497 13 4 6 2.7 O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1 10.1016/j.ejmech.2022.114961
9997789 186407 None 1 Human Functional pEC50 = 5.4 5.4 -107 2
Agonist activity at beta1 adrenoceptor (unknown origin)Agonist activity at beta1 adrenoceptor (unknown origin)
ChEMBL 310 3 3 3 3.4 CC(C)(C)NC(CO)c1cc(Cl)c(N)c(C(F)(F)F)c1 10.1021/acs.jmedchem.0c01195
CHEMBL4874511 186407 None 1 Human Functional pEC50 = 5.4 5.4 -107 2
Agonist activity at beta1 adrenoceptor (unknown origin)Agonist activity at beta1 adrenoceptor (unknown origin)
ChEMBL 310 3 3 3 3.4 CC(C)(C)NC(CO)c1cc(Cl)c(N)c(C(F)(F)F)c1 10.1021/acs.jmedchem.0c01195
CHEMBL5192245 186407 None 1 Human Functional pEC50 = 5.4 5.4 -107 2
Agonist activity at beta1 adrenoceptor (unknown origin)Agonist activity at beta1 adrenoceptor (unknown origin)
ChEMBL 310 3 3 3 3.4 CC(C)(C)NC(CO)c1cc(Cl)c(N)c(C(F)(F)F)c1 10.1021/acs.jmedchem.0c01195
24895263 194658 None 0 Human Functional pEC50 = 7.4 7.4 -1122 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 475 10 4 6 4.6 Nc1ccc([C@@H](O)CNCCc2ccc(-c3ccc(C(=O)O)c(OC4CCCCC4)c3)cc2)cn1 10.1021/jm8000345
CHEMBL529659 194658 None 0 Human Functional pEC50 = 7.4 7.4 -1122 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 475 10 4 6 4.6 Nc1ccc([C@@H](O)CNCCc2ccc(-c3ccc(C(=O)O)c(OC4CCCCC4)c3)cc2)cn1 10.1021/jm8000345
44591508 179101 None 0 Human Functional pEC50 = 7.4 7.4 -1122 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 475 10 4 6 4.6 Nc1ccncc1[C@@H](O)CNCCc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1 10.1021/jm9000709
CHEMBL470857 179101 None 0 Human Functional pEC50 = 7.4 7.4 -1122 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 475 10 4 6 4.6 Nc1ccncc1[C@@H](O)CNCCc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1 10.1021/jm9000709
319 1324 None 32 Human Functional pEC50 = 7.4 7.4 -43 18
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2011.05.097
321 1324 None 32 Human Functional pEC50 = 7.4 7.4 -43 18
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2011.05.097
444031 1324 None 32 Human Functional pEC50 = 7.4 7.4 -43 18
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2011.05.097
444031.0 1324 None 32 Human Functional pEC50 = 7.4 7.4 -43 18
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2011.05.097
784 1324 None 32 Human Functional pEC50 = 7.4 7.4 -43 18
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2011.05.097
CHEMBL1346 1324 None 32 Human Functional pEC50 = 7.4 7.4 -43 18
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2011.05.097
DB00496 1324 None 32 Human Functional pEC50 = 7.4 7.4 -43 18
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1016/j.bmcl.2011.05.097
56670158 64117 None 0 Human Functional pEC50 = 7.4 7.4 -15 2
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 497 13 5 7 2.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCC[S+]([O-])CCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807830 64117 None 0 Human Functional pEC50 = 7.4 7.4 -15 2
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 497 13 5 7 2.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCC[S+]([O-])CCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
16049309 64121 None 0 Human Functional pEC50 = 7.4 7.4 -100 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 481 13 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3ccccc3Cl)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807870 64121 None 0 Human Functional pEC50 = 7.4 7.4 -100 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 481 13 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3ccccc3Cl)c2s1 10.1016/j.bmcl.2011.05.097
56663238 64123 None 0 Human Functional pEC50 = 7.4 7.4 -251 2
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 465 13 5 7 2.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807872 64123 None 0 Human Functional pEC50 = 7.4 7.4 -251 2
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 465 13 5 7 2.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
1239 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
3410 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
3410.0 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
3465 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
CHEMBL1256786 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
DB00983 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
3083544 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1016/j.bmc.2011.08.043
3083544.0 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1016/j.bmc.2011.08.043
CHEMBL1200811 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1016/j.bmc.2011.08.043
CHEMBL1363 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1016/j.bmc.2011.08.043
CHEMBL1951071 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1016/j.bmc.2011.08.043
CHEMBL605993 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1016/j.bmc.2011.08.043
DB00983 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1016/j.bmc.2011.08.043
DB01274 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1016/j.bmc.2011.08.043
10288976 66601 None 0 Human Functional pEC50 = 7.4 7.4 -251 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 487 17 6 6 3.9 Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1 10.1016/j.bmc.2011.08.043
CHEMBL1835862 66601 None 0 Human Functional pEC50 = 7.4 7.4 -251 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 487 17 6 6 3.9 Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1 10.1016/j.bmc.2011.08.043
CHEMBL1852543 66601 None 0 Human Functional pEC50 = 7.4 7.4 -251 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 487 17 6 6 3.9 Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1 10.1016/j.bmc.2011.08.043
1239 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
3410 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
3410.0 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
3465 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
CHEMBL1256786 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
DB00983 1677 None 37 Human Functional pEC50 = 7.4 7.4 -67 6
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
3083544 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/jm100326d
3083544.0 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/jm100326d
CHEMBL1200811 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/jm100326d
CHEMBL1363 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/jm100326d
CHEMBL1951071 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/jm100326d
CHEMBL605993 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/jm100326d
DB00983 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/jm100326d
DB01274 26817 None 34 Human Functional pEC50 = 7.4 7.4 -199 6
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1021/jm100326d
49861320 54982 None 0 Human Functional pEC50 = 6.4 6.4 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 426 11 3 5 3.1 O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1204003 54982 None 0 Human Functional pEC50 = 6.4 6.4 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 426 11 3 5 3.1 O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1615579 54982 None 0 Human Functional pEC50 = 6.4 6.4 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 426 11 3 5 3.1 O=S(=O)(Nc1ccccc1)c1ccc(CCNC[C@@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
44565932 187117 None 0 Human Functional pEC50 = 6.4 6.4 -4897 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 528 11 4 8 3.4 CC(C)Sc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL490733 187117 None 0 Human Functional pEC50 = 6.4 6.4 -4897 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 528 11 4 8 3.4 CC(C)Sc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
10305108 111506 None 0 Human Functional pEC50 = 6.4 6.4 -77 3
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 659 17 6 8 4.2 CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)c4c3CCC(=O)N4)CC2)cc1 10.1016/s0960-894x(02)00607-8
CHEMBL327519 111506 None 0 Human Functional pEC50 = 6.4 6.4 -77 3
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 659 17 6 8 4.2 CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)c4c3CCC(=O)N4)CC2)cc1 10.1016/s0960-894x(02)00607-8
44441233 148144 None 0 Human Functional pEC50 = 6.4 6.4 -100 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 9 4 6 3.8 C[C@H](CNc1cccc(-c2ocnc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL393471 148144 None 0 Human Functional pEC50 = 6.4 6.4 -100 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 9 4 6 3.8 C[C@H](CNc1cccc(-c2ocnc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
10184665 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1016/j.bmc.2011.08.043
10184665.0 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1016/j.bmc.2011.08.043
4799 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1016/j.bmc.2011.08.043
7353 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1016/j.bmc.2011.08.043
CHEMBL1198857 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1016/j.bmc.2011.08.043
DB09082 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1016/j.bmc.2011.08.043
10184665 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1021/jm100326d
10184665.0 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1021/jm100326d
4799 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1021/jm100326d
7353 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1021/jm100326d
CHEMBL1198857 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1021/jm100326d
DB09082 3991 None 42 Human Functional pEC50 = 6.4 6.4 -173 10
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1021/jm100326d
11038599 47882 None 0 Human Functional pEC50 = 6.4 6.4 -25 3
Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 516 11 5 6 3.7 C[C@H](CNc1cccc(CNC(=O)NS(=O)(=O)c2ccccc2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
CHEMBL154906 47882 None 0 Human Functional pEC50 = 6.4 6.4 -25 3
Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 516 11 5 6 3.7 C[C@H](CNc1cccc(CNC(=O)NS(=O)(=O)c2ccccc2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
9512 3636 None 34 Human Functional pEC50 = 5.4 5.4 -1202 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 410 9 4 4 4.4 Clc1cccc(c1)[C@H](CNCCNc1cccc(c1)c1cccc(c1)C(=O)O)O 10.1021/jm0509445
9887812 3636 None 34 Human Functional pEC50 = 5.4 5.4 -1202 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 410 9 4 4 4.4 Clc1cccc(c1)[C@H](CNCCNc1cccc(c1)c1cccc(c1)C(=O)O)O 10.1021/jm0509445
CHEMBL208427 3636 None 34 Human Functional pEC50 = 5.4 5.4 -1202 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 410 9 4 4 4.4 Clc1cccc(c1)[C@H](CNCCNc1cccc(c1)c1cccc(c1)C(=O)O)O 10.1021/jm0509445
DB06190 3636 None 34 Human Functional pEC50 = 5.4 5.4 -1202 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 410 9 4 4 4.4 Clc1cccc(c1)[C@H](CNCCNc1cccc(c1)c1cccc(c1)C(=O)O)O 10.1021/jm0509445
44441236 93476 None 0 Human Functional pEC50 = 5.4 5.4 -3162 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 416 9 4 5 4.5 O=C(O)c1ccsc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1 10.1016/j.bmcl.2007.05.069
CHEMBL245875 93476 None 0 Human Functional pEC50 = 5.4 5.4 -3162 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 416 9 4 5 4.5 O=C(O)c1ccsc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1 10.1016/j.bmcl.2007.05.069
10298567 65974 None 0 Human Functional pEC50 = 8.4 8.4 -5 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 465 12 5 6 3.3 COc1cccc(NC(=O)Nc2ccc(C[C@@H](CO)NC[C@H](O)COc3ccccc3)cc2)c1 10.1016/j.bmcl.2004.11.001
CHEMBL183611 65974 None 0 Human Functional pEC50 = 8.4 8.4 -5 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 465 12 5 6 3.3 COc1cccc(NC(=O)Nc2ccc(C[C@@H](CO)NC[C@H](O)COc3ccccc3)cc2)c1 10.1016/j.bmcl.2004.11.001
164625303 188696 None 0 Human Functional pEC50 = 8.4 8.4 -316 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL4873082 188696 None 0 Human Functional pEC50 = 8.4 8.4 -316 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL5028871 188696 None 0 Human Functional pEC50 = 8.4 8.4 -316 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
164623918 188685 None 0 Human Functional pEC50 = 8.4 8.4 -199 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 374 7 4 4 2.8 O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL4872480 188685 None 0 Human Functional pEC50 = 8.4 8.4 -199 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 374 7 4 4 2.8 O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL5028793 188685 None 0 Human Functional pEC50 = 8.4 8.4 -199 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 374 7 4 4 2.8 O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
164608750 188565 None 0 Human Functional pEC50 = 8.4 8.4 -181 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL4846631 188565 None 0 Human Functional pEC50 = 8.4 8.4 -181 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL5027923 188565 None 0 Human Functional pEC50 = 8.4 8.4 -181 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
164615474 188615 None 0 Human Functional pEC50 = 8.4 8.4 -61 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4847767 188615 None 0 Human Functional pEC50 = 8.4 8.4 -61 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028315 188615 None 0 Human Functional pEC50 = 8.4 8.4 -61 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164617688 188629 None 0 Human Functional pEC50 = 8.4 8.4 -416 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4847536 188629 None 0 Human Functional pEC50 = 8.4 8.4 -416 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028449 188629 None 0 Human Functional pEC50 = 8.4 8.4 -416 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
56598967 88295 None 0 Human Functional pEC50 = 8.4 8.4 2238 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 457 14 4 6 3.2 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccccc1 10.1021/jm400348g
CHEMBL2348211 88295 None 0 Human Functional pEC50 = 8.4 8.4 2238 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 457 14 4 6 3.2 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccccc1 10.1021/jm400348g
45101520 201240 None 0 Human Functional pEC50 = 8.4 8.4 -3 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 513 12 7 8 1.2 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)CN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL583235 201240 None 0 Human Functional pEC50 = 8.4 8.4 -3 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 513 12 7 8 1.2 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)CN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
46232769 203297 None 0 Human Functional pEC50 = 8.4 8.4 -6 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL601036 203297 None 0 Human Functional pEC50 = 8.4 8.4 -6 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
164614743 188606 None 0 Human Functional pEC50 = 8.3 8.3 -134 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4860764 188606 None 0 Human Functional pEC50 = 8.3 8.3 -134 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028269 188606 None 0 Human Functional pEC50 = 8.3 8.3 -134 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
45484536 199670 None 0 Human Functional pEC50 = 8.3 8.3 -5 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 527 13 7 8 1.6 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)CCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL568239 199670 None 0 Human Functional pEC50 = 8.3 8.3 -5 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 527 13 7 8 1.6 CC(C)(Cc1ccc(NC(=O)CCCNC(=O)CCN)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
559926 97060 None 2 Guinea pig Functional pEC50 = 8.3 8.3 27 2
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 255 5 4 5 1.2 CC(C)(C)NCC(O)COc1ccc(O)c(O)c1 10.1021/jm00107a027
CHEMBL266619 97060 None 2 Guinea pig Functional pEC50 = 8.3 8.3 27 2
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 255 5 4 5 1.2 CC(C)(C)NCC(O)COc1ccc(O)c(O)c1 10.1021/jm00107a027
45270673 197880 None 0 Human Functional pEC50 = 7.4 7.4 58 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 406 10 3 5 3.9 O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)Oc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1203992 197880 None 0 Human Functional pEC50 = 7.4 7.4 58 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 406 10 3 5 3.9 O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)Oc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL552253 197880 None 0 Human Functional pEC50 = 7.4 7.4 58 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 406 10 3 5 3.9 O=C(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)Oc1ccccc1 10.1016/j.bmc.2009.06.031
45273280 198175 None 0 Human Functional pEC50 = 7.4 7.4 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 435 11 4 4 3.7 O[C@@H](CNCCc1ccc(NC(=S)NCc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1204006 198175 None 0 Human Functional pEC50 = 7.4 7.4 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 435 11 4 4 3.7 O[C@@H](CNCCc1ccc(NC(=S)NCc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL557095 198175 None 0 Human Functional pEC50 = 7.4 7.4 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 435 11 4 4 3.7 O[C@@H](CNCCc1ccc(NC(=S)NCc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
44396513 66744 None 0 Human Functional pEC50 = 7.4 7.4 -30 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 577 12 4 8 4.4 CC(C)S(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12 10.1016/j.bmcl.2004.10.035
CHEMBL185660 66744 None 0 Human Functional pEC50 = 7.4 7.4 -30 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 577 12 4 8 4.4 CC(C)S(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12 10.1016/j.bmcl.2004.10.035
10420352 168843 None 6 Guinea pig Functional pEC50 = 7.4 7.4 83 2
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 201 3 4 4 0.5 CNCC(O)c1ccc(O)c(O)c1F 10.1021/jm00118a019
CHEMBL43711 168843 None 6 Guinea pig Functional pEC50 = 7.4 7.4 83 2
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 201 3 4 4 0.5 CNCC(O)c1ccc(O)c(O)c1F 10.1021/jm00118a019
10076548 163359 None 0 Human Functional pEC50 = 7.4 7.4 -4 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 562 13 5 8 2.7 CCCCN(C(=O)CC(=O)O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1 10.1021/jm000544b
CHEMBL418600 163359 None 0 Human Functional pEC50 = 7.4 7.4 -4 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 562 13 5 8 2.7 CCCCN(C(=O)CC(=O)O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1 10.1021/jm000544b
24893966 176844 None 0 Human Functional pEC50 = 6.4 6.4 -724 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 449 12 3 5 4.8 CC(C)COc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL460257 176844 None 0 Human Functional pEC50 = 6.4 6.4 -724 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 449 12 3 5 4.8 CC(C)COc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
44331766 4660 None 0 Human Functional pEC50 = 6.4 6.4 -2 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 449 9 3 4 4.3 O[C@@H](CNCC1CCN(CCC(F)(F)F)CC1)COc1cccc2[nH]c3ccccc3c12 10.1016/s0960-894x(02)00607-8
CHEMBL103137 4660 None 0 Human Functional pEC50 = 6.4 6.4 -2 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 449 9 3 4 4.3 O[C@@H](CNCC1CCN(CCC(F)(F)F)CC1)COc1cccc2[nH]c3ccccc3c12 10.1016/s0960-894x(02)00607-8
22063464 203467 None 0 Human Functional pEC50 = 7.4 7.4 -10 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1cccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1 10.1016/j.bmcl.2009.12.087
CHEMBL602257 203467 None 0 Human Functional pEC50 = 7.4 7.4 -10 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1cccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1 10.1016/j.bmcl.2009.12.087
10189730 5279 None 0 Human Functional pEC50 = 6.4 6.4 -426 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 647 14 6 8 3.4 CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCCc2ccc(NC3CCN(C(=O)NCc4cc(F)ccc4F)CC3)cc2)ccc1O 10.1016/s0960-894x(01)00645-x
CHEMBL106511 5279 None 0 Human Functional pEC50 = 6.4 6.4 -426 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 647 14 6 8 3.4 CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCCc2ccc(NC3CCN(C(=O)NCc4cc(F)ccc4F)CC3)cc2)ccc1O 10.1016/s0960-894x(01)00645-x
145984324 165934 None 0 Human Functional pEC50 = 6.4 6.4 -7 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 449 11 4 4 4.6 CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=S)Nc2ccccc2)cc1 10.1016/j.ejmech.2018.03.032
CHEMBL4248727 165934 None 0 Human Functional pEC50 = 6.4 6.4 -7 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 449 11 4 4 4.6 CCc1ccccc1OC[C@@H](O)CNCCc1ccc(NC(=S)Nc2ccccc2)cc1 10.1016/j.ejmech.2018.03.032
44574723 178628 None 0 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 439 11 3 5 3.5 O=C(Cc1cccc(Cl)n1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL466726 178628 None 0 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 439 11 3 5 3.5 O=C(Cc1cccc(Cl)n1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
155567283 176074 None 0 Human Functional pEC50 = 7.4 7.4 -588 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.bmc.2018.10.043
CHEMBL4588479 176074 None 0 Human Functional pEC50 = 7.4 7.4 -588 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.bmc.2018.10.043
44377771 165642 None 0 Human Functional pEC50 = 6.4 6.4 -70 3
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 596 10 5 9 3.4 O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)c4ccc(O)c(NS(=O)(=O)c5ccccc5)c4)CC3)cc2)S1 10.1016/s0960-894x(01)00063-4
CHEMBL424167 165642 None 0 Human Functional pEC50 = 6.4 6.4 -70 3
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
ChEMBL 596 10 5 9 3.4 O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)c4ccc(O)c(NS(=O)(=O)c5ccccc5)c4)CC3)cc2)S1 10.1016/s0960-894x(01)00063-4
1028 291 None 40 Guinea pig Functional pEC50 = 6.4 6.4 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
139148732 291 None 40 Guinea pig Functional pEC50 = 6.4 6.4 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
479 291 None 40 Guinea pig Functional pEC50 = 6.4 6.4 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
5816 291 None 40 Guinea pig Functional pEC50 = 6.4 6.4 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
5816.0 291 None 40 Guinea pig Functional pEC50 = 6.4 6.4 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
CHEMBL679 291 None 40 Guinea pig Functional pEC50 = 6.4 6.4 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
DB00668 291 None 40 Guinea pig Functional pEC50 = 6.4 6.4 -6 19
Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00019a001
46232856 203800 None 0 Human Functional pEC50 = 6.4 6.4 -128 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 424 6 4 5 3.4 CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL604333 203800 None 0 Human Functional pEC50 = 6.4 6.4 -128 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 424 6 4 5 3.4 CC(C)(Cc1cccc(C(F)(F)F)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
10651147 110746 None 0 Human Functional pEC50 = 4.4 4.4 -10964 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 596 12 6 8 2.5 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O 10.1021/jm000544b
CHEMBL32599 110746 None 0 Human Functional pEC50 = 4.4 4.4 -10964 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 596 12 6 8 2.5 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O 10.1021/jm000544b
44392542 65883 None 0 Human Functional pEC50 = 7.4 7.4 -6 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 543 11 4 6 5.5 C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NCc2ccc3ccccc3c2)c1 10.1016/j.bmcl.2004.12.033
CHEMBL183552 65883 None 0 Human Functional pEC50 = 7.4 7.4 -6 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 543 11 4 6 5.5 C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NCc2ccc3ccccc3c2)c1 10.1016/j.bmcl.2004.12.033
11432806 66218 None 0 Human Functional pEC50 = 7.4 7.4 -134 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 549 11 4 8 3.6 C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.09.054
11432806 66218 None 0 Human Functional pEC50 = 7.4 7.4 -134 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 549 11 4 8 3.6 C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
CHEMBL184407 66218 None 0 Human Functional pEC50 = 7.4 7.4 -134 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 549 11 4 8 3.6 C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.09.054
CHEMBL184407 66218 None 0 Human Functional pEC50 = 7.4 7.4 -134 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 549 11 4 8 3.6 C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
164612025 188584 None 0 Human Functional pEC50 = 7.4 7.4 -2454 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4860454 188584 None 0 Human Functional pEC50 = 7.4 7.4 -2454 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028117 188584 None 0 Human Functional pEC50 = 7.4 7.4 -2454 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
24895669 190776 None 0 Human Functional pEC50 = 6.4 6.4 -7079 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 435 10 4 5 4.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(O)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL518168 190776 None 0 Human Functional pEC50 = 6.4 6.4 -7079 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 435 10 4 5 4.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(O)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
44392575 64393 None 0 Human Functional pEC50 = 7.4 7.4 -2 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 441 10 4 6 2.8 C#CCNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1 10.1016/j.bmcl.2004.12.033
CHEMBL181300 64393 None 0 Human Functional pEC50 = 7.4 7.4 -2 3
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
ChEMBL 441 10 4 6 2.8 C#CCNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1 10.1016/j.bmcl.2004.12.033
52949489 17554 None 0 Human Functional pEC50 = 6.4 6.4 -21 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 490 9 2 8 4.4 COc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1 10.1016/j.bmcl.2010.08.039
CHEMBL1258024 17554 None 0 Human Functional pEC50 = 6.4 6.4 -21 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 490 9 2 8 4.4 COc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1 10.1016/j.bmcl.2010.08.039
44268324 16791 None 0 Human Functional pEC50 = 6.4 6.4 -141 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 476 11 4 6 3.4 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccc(Cl)cc1 10.1016/s0960-894x(98)00169-3
CHEMBL12450 16791 None 0 Human Functional pEC50 = 6.4 6.4 -141 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 476 11 4 6 3.4 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccc(Cl)cc1 10.1016/s0960-894x(98)00169-3
10626150 100080 None 0 Human Functional pEC50 = 5.4 5.4 -295 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 534 11 5 9 1.3 CCOC(=O)CNC(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1 10.1021/jm000544b
CHEMBL286868 100080 None 0 Human Functional pEC50 = 5.4 5.4 -295 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 534 11 5 9 1.3 CCOC(=O)CNC(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1 10.1021/jm000544b
44336180 6471 None 0 Human Functional pEC50 = 6.3 6.3 -15 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 554 12 5 6 4.0 O=C(NCc1ccc(F)cc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL108263 6471 None 0 Human Functional pEC50 = 6.3 6.3 -15 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 554 12 5 6 4.0 O=C(NCc1ccc(F)cc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
11270071 99044 None 0 Human Functional pEC50 = 7.3 7.3 1 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 328 6 3 2 4.1 C[C@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
CHEMBL279931 99044 None 0 Human Functional pEC50 = 7.3 7.3 1 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 328 6 3 2 4.1 C[C@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
5311452 3671 None 7 Human Functional pEC50 = 7.3 7.3 -5 4
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 325 7 2 3 3.7 CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O 10.1016/j.ejmech.2022.114961
547 3671 None 7 Human Functional pEC50 = 7.3 7.3 -5 4
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 325 7 2 3 3.7 CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O 10.1016/j.ejmech.2022.114961
CHEMBL1326499 3671 None 7 Human Functional pEC50 = 7.3 7.3 -5 4
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 325 7 2 3 3.7 CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O 10.1016/j.ejmech.2022.114961
24949564 189630 None 0 Human Functional pEC50 = 6.3 6.3 -147 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 452 7 4 5 4.6 Nc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1 10.1021/jm800222k
CHEMBL514094 189630 None 0 Human Functional pEC50 = 6.3 6.3 -147 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 452 7 4 5 4.6 Nc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1 10.1021/jm800222k
24893964 186771 None 0 Human Functional pEC50 = 6.3 6.3 -1862 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 460 10 3 5 5.0 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1 10.1021/jm8000345
CHEMBL488224 186771 None 0 Human Functional pEC50 = 6.3 6.3 -1862 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 460 10 3 5 5.0 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1 10.1021/jm8000345
24893964 186771 None 0 Human Functional pEC50 = 6.3 6.3 -1862 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 460 10 3 5 5.0 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1 10.1021/jm9000709
CHEMBL488224 186771 None 0 Human Functional pEC50 = 6.3 6.3 -1862 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 460 10 3 5 5.0 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1 10.1021/jm9000709
3038500 9342 None 11 Human Functional pEC50 = 5.3 5.3 -831 6
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.
ChEMBL 624 11 3 7 6.6 O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1021/jm000286i
CHEMBL111201 9342 None 11 Human Functional pEC50 = 5.3 5.3 -831 6
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.
ChEMBL 624 11 3 7 6.6 O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1021/jm000286i
10187653 4337 None 0 Human Functional pEC50 = 6.3 6.3 -3 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 554 11 5 7 3.5 O=C(Nc1ccccc1)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
CHEMBL100970 4337 None 0 Human Functional pEC50 = 6.3 6.3 -3 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 554 11 5 7 3.5 O=C(Nc1ccccc1)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
44396736 66889 None 0 Human Functional pEC50 = 7.3 7.3 -11 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 617 12 4 9 5.1 C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3cccs3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
CHEMBL186271 66889 None 0 Human Functional pEC50 = 7.3 7.3 -11 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 617 12 4 9 5.1 C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3cccs3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
44127056 197821 None 0 Human Functional pEC50 = 6.3 6.3 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 426 11 4 6 3.2 O=C(Cc1ccsc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL551892 197821 None 0 Human Functional pEC50 = 6.3 6.3 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 426 11 4 6 3.2 O=C(Cc1ccsc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
24949420 188221 None 1 Human Functional pEC50 = 6.3 6.3 -51 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 422 6 3 4 4.3 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)nc1 10.1021/jm800222k
CHEMBL498304 188221 None 1 Human Functional pEC50 = 6.3 6.3 -51 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 422 6 3 4 4.3 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)nc1 10.1021/jm800222k
42639652 12735 None 0 Human Functional pEC50 = 6.3 6.3 -1513 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 495 11 3 6 3.5 CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL1187716 12735 None 0 Human Functional pEC50 = 6.3 6.3 -1513 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 495 11 3 6 3.5 CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL516209 12735 None 0 Human Functional pEC50 = 6.3 6.3 -1513 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 495 11 3 6 3.5 CC(C)Cc1cc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
45483847 199268 None 0 Human Functional pEC50 = 8.3 8.3 -2 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 432 7 4 5 4.0 CC(C)(Cc1ccc(-c2ccccc2)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL565686 199268 None 0 Human Functional pEC50 = 8.3 8.3 -2 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 432 7 4 5 4.0 CC(C)(Cc1ccc(-c2ccccc2)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
45483816 199592 None 0 Human Functional pEC50 = 8.3 8.3 -12 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1cccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)c1 10.1016/j.bmcl.2009.10.013
CHEMBL567833 199592 None 0 Human Functional pEC50 = 8.3 8.3 -12 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1cccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)c1 10.1016/j.bmcl.2009.10.013
52947562 17694 None 0 Human Functional pEC50 = 8.3 8.3 3 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 384 7 2 7 2.7 OC(CNC1CCN(c2ncnc3sccc23)CC1)COc1ccccc1 10.1016/j.bmcl.2010.08.039
CHEMBL1258486 17694 None 0 Human Functional pEC50 = 8.3 8.3 3 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 384 7 2 7 2.7 OC(CNC1CCN(c2ncnc3sccc23)CC1)COc1ccccc1 10.1016/j.bmcl.2010.08.039
11026016 46714 None 0 Human Functional pEC50 = 8.3 8.3 1 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 411 10 4 5 2.5 C[C@H](CNc1ccc(CNS(C)(=O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
CHEMBL153916 46714 None 0 Human Functional pEC50 = 8.3 8.3 1 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 411 10 4 5 2.5 C[C@H](CNc1ccc(CNS(C)(=O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
10902809 48091 None 0 Human Functional pEC50 = 8.3 8.3 1 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 304 7 3 3 3.5 C[C@H](CNc1ccccc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
CHEMBL155072 48091 None 0 Human Functional pEC50 = 8.3 8.3 1 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 304 7 3 3 3.5 C[C@H](CNc1ccccc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
2419 3463 None 53 Guinea pig Functional pEC50 = 8.3 8.3 -8 19
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
5152 3463 None 53 Guinea pig Functional pEC50 = 8.3 8.3 -8 19
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
5152.0 3463 None 53 Guinea pig Functional pEC50 = 8.3 8.3 -8 19
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
559 3463 None 53 Guinea pig Functional pEC50 = 8.3 8.3 -8 19
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
CHEMBL1263 3463 None 53 Guinea pig Functional pEC50 = 8.3 8.3 -8 19
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
DB00938 3463 None 53 Guinea pig Functional pEC50 = 8.3 8.3 -8 19
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
155543358 174877 None 0 Human Functional pEC50 = 8.3 8.3 -102 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3ccccc3O)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4561253 174877 None 0 Human Functional pEC50 = 8.3 8.3 -102 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3ccccc3O)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
45484568 200806 None 0 Human Functional pEC50 = 8.3 8.3 -10 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 541 13 6 8 1.8 CN(C)CC(=O)NCCCC(=O)Nc1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.06.104
CHEMBL576428 200806 None 0 Human Functional pEC50 = 8.3 8.3 -10 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 541 13 6 8 1.8 CN(C)CC(=O)NCCCC(=O)Nc1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.06.104
45483843 199492 None 0 Human Functional pEC50 = 8.3 8.3 -9 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 384 7 4 5 2.9 CCc1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.10.013
CHEMBL567192 199492 None 0 Human Functional pEC50 = 8.3 8.3 -9 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 384 7 4 5 2.9 CCc1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.10.013
45484569 200090 None 0 Human Functional pEC50 = 8.2 8.2 -4 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 596 13 6 9 1.5 CN1CCN(CC(=O)NCCCC(=O)Nc2ccc(CC(C)(C)NCC(O)c3ccc(O)c4c3OCC(=O)N4)cc2)CC1 10.1016/j.bmcl.2009.06.104
CHEMBL570834 200090 None 0 Human Functional pEC50 = 8.2 8.2 -4 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 596 13 6 9 1.5 CN1CCN(CC(=O)NCCCC(=O)Nc2ccc(CC(C)(C)NCC(O)c3ccc(O)c4c3OCC(=O)N4)cc2)CC1 10.1016/j.bmcl.2009.06.104
45268128 198778 None 0 Human Functional pEC50 = 7.3 7.3 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 427 10 4 4 3.9 O[C@@H](CNCCc1ccc(NC(=S)NC2CCCCC2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1203988 198778 None 0 Human Functional pEC50 = 7.3 7.3 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 427 10 4 4 3.9 O[C@@H](CNCCc1ccc(NC(=S)NC2CCCCC2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL562315 198778 None 0 Human Functional pEC50 = 7.3 7.3 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 427 10 4 4 3.9 O[C@@H](CNCCc1ccc(NC(=S)NC2CCCCC2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
10233153 4230 None 0 Human Functional pEC50 = 7.3 7.3 -5 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 642 11 5 9 3.1 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4ccc5c(C(=O)O)cccc54)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
CHEMBL100351 4230 None 0 Human Functional pEC50 = 7.3 7.3 -5 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 642 11 5 9 3.1 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4ccc5c(C(=O)O)cccc54)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
10553602 127220 None 0 Human Functional pEC50 = 7.3 7.3 -1 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 506 10 6 8 0.9 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(=O)NCC(=O)O)cc3)CC2)ccc1O 10.1021/jm000544b
CHEMBL36568 127220 None 0 Human Functional pEC50 = 7.3 7.3 -1 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 506 10 6 8 0.9 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(=O)NCC(=O)O)cc3)CC2)ccc1O 10.1021/jm000544b
9893058 66403 None 0 Human Functional pEC50 = 7.3 7.3 -39 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 525 17 5 8 2.9 O=c1ccn(-c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)c(=O)[nH]1 10.1016/j.bmc.2011.05.064
CHEMBL1814267 66403 None 0 Human Functional pEC50 = 7.3 7.3 -39 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 525 17 5 8 2.9 O=c1ccn(-c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)c(=O)[nH]1 10.1016/j.bmc.2011.05.064
CHEMBL1851721 66403 None 0 Human Functional pEC50 = 7.3 7.3 -39 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 525 17 5 8 2.9 O=c1ccn(-c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)c(=O)[nH]1 10.1016/j.bmc.2011.05.064
56678849 66647 None 0 Human Functional pEC50 = 7.3 7.3 -63 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 541 18 5 8 2.7 O=C1NC(=O)N(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
CHEMBL1814275 66647 None 0 Human Functional pEC50 = 7.3 7.3 -63 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 541 18 5 8 2.7 O=C1NC(=O)N(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
CHEMBL1852744 66647 None 0 Human Functional pEC50 = 7.3 7.3 -63 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 541 18 5 8 2.7 O=C1NC(=O)N(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
56675663 66610 None 0 Human Functional pEC50 = 7.3 7.3 -50 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 541 17 6 6 4.6 NC(=O)Nc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.043
CHEMBL1835861 66610 None 0 Human Functional pEC50 = 7.3 7.3 -50 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 541 17 6 6 4.6 NC(=O)Nc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.043
CHEMBL1852575 66610 None 0 Human Functional pEC50 = 7.3 7.3 -50 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 541 17 6 6 4.6 NC(=O)Nc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.043
46833102 14211 None 0 Human Functional pEC50 = 7.3 7.3 -31 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 496 17 5 8 1.9 NS(=O)(=O)c1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL1084656 14211 None 0 Human Functional pEC50 = 7.3 7.3 -31 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 496 17 5 8 1.9 NS(=O)(=O)c1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL1198882 14211 None 0 Human Functional pEC50 = 7.3 7.3 -31 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 496 17 5 8 1.9 NS(=O)(=O)c1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
44574913 178681 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 526 15 2 6 4.5 CCCN(C(=O)Cc1nccn1Cc1ccccc1)c1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL467117 178681 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 526 15 2 6 4.5 CCCN(C(=O)Cc1nccn1Cc1ccccc1)c1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
24895667 176956 None 0 Human Functional pEC50 = 6.3 6.3 -208 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 453 10 3 4 5.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(Cl)cc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL461282 176956 None 0 Human Functional pEC50 = 6.3 6.3 -208 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 453 10 3 4 5.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3ccc(Cl)cc3)cc2)ccc1C(=O)O 10.1021/jm8000345
10003858 189204 None 1 Human Functional pEC50 = 6.3 6.3 -3548 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 449 10 4 5 4.8 CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccc(O)cc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL510100 189204 None 1 Human Functional pEC50 = 6.3 6.3 -3548 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 449 10 4 5 4.8 CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccc(O)cc3)cc2)ccc1C(=O)O 10.1021/jm8000345
42625513 12563 None 0 Human Functional pEC50 = 6.3 6.3 -1000 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm801016j
CHEMBL1186722 12563 None 0 Human Functional pEC50 = 6.3 6.3 -1000 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm801016j
CHEMBL475389 12563 None 0 Human Functional pEC50 = 6.3 6.3 -1000 4
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm801016j
42625515 12734 None 0 Human Functional pEC50 = 6.3 6.3 -794 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 508 18 5 7 3.0 CNS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1187711 12734 None 0 Human Functional pEC50 = 6.3 6.3 -794 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 508 18 5 7 3.0 CNS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL516056 12734 None 0 Human Functional pEC50 = 6.3 6.3 -794 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 508 18 5 7 3.0 CNS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
11718543 165927 None 0 Human Functional pEC50 = 5.3 5.3 -125 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 411 9 4 5 3.8 O=C(O)c1cccc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)n1 10.1021/jm0509445
CHEMBL424866 165927 None 0 Human Functional pEC50 = 5.3 5.3 -125 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 411 9 4 5 3.8 O=C(O)c1cccc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)n1 10.1021/jm0509445
9801145 93475 None 0 Human Functional pEC50 = 5.3 5.3 -630 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 400 9 4 5 4.0 O=C(O)c1ccoc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1 10.1016/j.bmcl.2007.05.069
CHEMBL245874 93475 None 0 Human Functional pEC50 = 5.3 5.3 -630 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 400 9 4 5 4.0 O=C(O)c1ccoc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1 10.1016/j.bmcl.2007.05.069
11605652 12559 None 0 Human Functional pEC50 = 5.3 5.3 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1186715 12559 None 0 Human Functional pEC50 = 5.3 5.3 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL475236 12559 None 0 Human Functional pEC50 = 5.3 5.3 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
44392240 64340 None 0 Human Functional pEC50 = 7.3 7.3 -6 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 401 12 5 5 2.2 CCCNC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
CHEMBL181115 64340 None 0 Human Functional pEC50 = 7.3 7.3 -6 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 401 12 5 5 2.2 CCCNC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmcl.2004.11.001
44580010 186905 None 0 Human Functional pEC50 = 6.3 6.3 -46 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 441 10 3 5 4.7 COc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
CHEMBL489199 186905 None 0 Human Functional pEC50 = 6.3 6.3 -46 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 441 10 3 5 4.7 COc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
24894319 189968 None 0 Human Functional pEC50 = 6.3 6.3 -213 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 435 11 3 5 4.5 CC(C)Oc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL516785 189968 None 0 Human Functional pEC50 = 6.3 6.3 -213 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 435 11 3 5 4.5 CC(C)Oc1cc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
10202842 164254 None 0 Human Functional pEC50 = 6.3 6.3 -16 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 428 10 5 6 1.9 NC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL421030 164254 None 0 Human Functional pEC50 = 6.3 6.3 -16 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 428 10 5 6 1.9 NC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
24895561 176958 None 0 Human Functional pEC50 = 7.3 7.3 -194 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 509 11 3 5 6.1 O=C(O)c1ccc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1 10.1021/jm8000345
CHEMBL461301 176958 None 0 Human Functional pEC50 = 7.3 7.3 -194 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 509 11 3 5 6.1 O=C(O)c1ccc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1 10.1021/jm8000345
44331443 4450 None 0 Human Functional pEC50 = 6.3 6.3 -26 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 689 14 7 9 2.3 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
CHEMBL101674 4450 None 0 Human Functional pEC50 = 6.3 6.3 -26 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 689 14 7 9 2.3 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
44331351 210600 None 0 Human Functional pEC50 = 6.3 6.3 -16 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 610 13 6 8 2.7 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(c3ccc(C(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
CHEMBL98088 210600 None 0 Human Functional pEC50 = 6.3 6.3 -16 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 610 13 6 8 2.7 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(c3ccc(C(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
10209574 5441 None 0 Human Functional pEC50 = 6.3 6.3 -22 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 554 12 5 6 4.0 O=C(NCc1cc(F)ccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL107382 5441 None 0 Human Functional pEC50 = 6.3 6.3 -22 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 554 12 5 6 4.0 O=C(NCc1cc(F)ccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
10304565 107433 None 0 Human Functional pEC50 = 6.3 6.3 -11 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 622 12 5 7 3.6 O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)c(F)c3)CC2)cc1 10.1016/s0960-894x(02)00607-8
CHEMBL317809 107433 None 0 Human Functional pEC50 = 6.3 6.3 -11 2
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 622 12 5 7 3.6 O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)c(F)c3)CC2)cc1 10.1016/s0960-894x(02)00607-8
44396577 66973 None 0 Human Functional pEC50 = 7.3 7.3 -25 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 561 12 4 6 5.9 C[C@H](Cc1c[nH]c2c(OCc3ccccc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
CHEMBL186676 66973 None 0 Human Functional pEC50 = 7.3 7.3 -25 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 561 12 4 6 5.9 C[C@H](Cc1c[nH]c2c(OCc3ccccc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
24822817 95348 None 0 Human Functional pEC50 = 7.3 7.3 -120 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 493 10 3 4 6.3 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1 10.1021/jm701324c
CHEMBL256418 95348 None 0 Human Functional pEC50 = 7.3 7.3 -120 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 493 10 3 4 6.3 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1 10.1021/jm701324c
24822817 95348 None 0 Human Functional pEC50 = 7.3 7.3 -120 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 493 10 3 4 6.3 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1 10.1021/jm8000345
CHEMBL256418 95348 None 0 Human Functional pEC50 = 7.3 7.3 -120 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 493 10 3 4 6.3 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1 10.1021/jm8000345
24822817 95348 None 0 Human Functional pEC50 = 7.3 7.3 -120 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 493 10 3 4 6.3 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1 10.1021/jm9000709
CHEMBL256418 95348 None 0 Human Functional pEC50 = 7.3 7.3 -120 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 493 10 3 4 6.3 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1 10.1021/jm9000709
44237613 58250 None 0 Rat Functional pEC50 = 6.3 6.3 -2754 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 502 10 6 6 3.4 COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682215 58250 None 0 Rat Functional pEC50 = 6.3 6.3 -2754 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 502 10 6 6 3.4 COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
44580009 186907 None 0 Human Functional pEC50 = 6.3 6.3 -42 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 425 9 3 4 5.0 Cc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
CHEMBL489201 186907 None 0 Human Functional pEC50 = 6.3 6.3 -42 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 425 9 3 4 5.0 Cc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
44127575 194936 None 0 Human Functional pEC50 = 6.3 6.3 -1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 426 11 4 6 3.2 O=C(Cc1cccs1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL539226 194936 None 0 Human Functional pEC50 = 6.3 6.3 -1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 426 11 4 6 3.2 O=C(Cc1cccs1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
45270391 197910 None 0 Human Functional pEC50 = 6.3 6.3 -1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 459 11 4 6 3.8 O=C(CC1C=Nc2ccccc21)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL552434 197910 None 0 Human Functional pEC50 = 6.3 6.3 -1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 459 11 4 6 3.8 O=C(CC1C=Nc2ccccc21)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
45273276 198140 None 0 Human Functional pEC50 = 7.3 7.3 -2 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 429 10 4 5 3.6 N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1204005 198140 None 0 Human Functional pEC50 = 7.3 7.3 -2 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 429 10 4 5 3.6 N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL556689 198140 None 0 Human Functional pEC50 = 7.3 7.3 -2 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 429 10 4 5 3.6 N#C/N=C(\Nc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
24822472 97467 None 0 Human Functional pEC50 = 6.2 6.2 -38 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 409 8 3 3 4.9 Cc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm701324c
CHEMBL269920 97467 None 0 Human Functional pEC50 = 6.2 6.2 -38 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 409 8 3 3 4.9 Cc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm701324c
44237670 58254 None 0 Rat Functional pEC50 = 5.2 5.2 -8128 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 534 9 6 5 5.4 O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)Nc1ccccc1-c1ccccc1 10.1016/j.bmcl.2010.12.096
CHEMBL1682219 58254 None 0 Rat Functional pEC50 = 5.2 5.2 -8128 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 534 9 6 5 5.4 O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)Nc1ccccc1-c1ccccc1 10.1016/j.bmcl.2010.12.096
44396737 66879 None 0 Human Functional pEC50 = 7.2 7.2 -47 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 683 14 4 10 5.2 CCOC(=O)c1ccc(S(=O)(=O)Oc2cccc3c(C[C@@H](C)NC[C@H](O)c4cccc(NS(=O)(=O)c5cccs5)c4)c[nH]c23)cc1 10.1016/j.bmcl.2004.10.035
CHEMBL186236 66879 None 0 Human Functional pEC50 = 7.2 7.2 -47 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 683 14 4 10 5.2 CCOC(=O)c1ccc(S(=O)(=O)Oc2cccc3c(C[C@@H](C)NC[C@H](O)c4cccc(NS(=O)(=O)c5cccs5)c4)c[nH]c23)cc1 10.1016/j.bmcl.2004.10.035
44444173 94034 None 0 Human Functional pEC50 = 7.2 7.2 -8 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levelAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP level
ChEMBL 516 11 4 7 3.3 CC(C)(Cc1ccc(Oc2ccc(C(N)=O)cn2)cc1)NC[C@H](O)COc1cccc2c1C1(CC1)C(=O)N2 10.1016/j.bmcl.2007.09.011
CHEMBL248547 94034 None 0 Human Functional pEC50 = 7.2 7.2 -8 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levelAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP level
ChEMBL 516 11 4 7 3.3 CC(C)(Cc1ccc(Oc2ccc(C(N)=O)cn2)cc1)NC[C@H](O)COc1cccc2c1C1(CC1)C(=O)N2 10.1016/j.bmcl.2007.09.011
44331426 4424 None 0 Human Functional pEC50 = 6.2 6.2 -114 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 578 13 7 9 1.0 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(c3ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
CHEMBL101521 4424 None 0 Human Functional pEC50 = 6.2 6.2 -114 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 578 13 7 9 1.0 CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(c3ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00608-x
44127048 197811 None 0 Human Functional pEC50 = 6.2 6.2 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 436 11 5 6 2.6 O=C(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C(O)c1ccccc1 10.1016/j.ejmech.2009.01.022
CHEMBL551832 197811 None 0 Human Functional pEC50 = 6.2 6.2 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 436 11 5 6 2.6 O=C(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)C(O)c1ccccc1 10.1016/j.ejmech.2009.01.022
1499 2091 None 34 Guinea pig Functional pEC50 = 8.2 8.2 -60 38
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00107a027
3779 2091 None 34 Guinea pig Functional pEC50 = 8.2 8.2 -60 38
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00107a027
3779.0 2091 None 34 Guinea pig Functional pEC50 = 8.2 8.2 -60 38
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00107a027
536 2091 None 34 Guinea pig Functional pEC50 = 8.2 8.2 -60 38
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00107a027
CHEMBL434 2091 None 34 Guinea pig Functional pEC50 = 8.2 8.2 -60 38
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00107a027
DB01064 2091 None 34 Guinea pig Functional pEC50 = 8.2 8.2 -60 38
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00107a027
24936491 17527 None 0 Human Functional pEC50 = 8.2 8.2 -2 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 494 8 3 8 4.2 Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccc(F)cc5)c34)CC2)cc1 10.1016/j.bmcl.2010.08.039
CHEMBL1257916 17527 None 0 Human Functional pEC50 = 8.2 8.2 -2 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 494 8 3 8 4.2 Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccc(F)cc5)c34)CC2)cc1 10.1016/j.bmcl.2010.08.039
9845282 75979 None 0 Human Functional pEC50 = 8.2 8.2 -63 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 424 9 4 4 4.8 C[C@H](CNc1cccc(-c2cccc(C(=O)O)c2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
CHEMBL205224 75979 None 0 Human Functional pEC50 = 8.2 8.2 -63 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 424 9 4 4 4.8 C[C@H](CNc1cccc(-c2cccc(C(=O)O)c2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
155564079 175515 None 0 Human Functional pEC50 = 8.2 8.2 -97 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 442 8 4 4 4.9 CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4575759 175515 None 0 Human Functional pEC50 = 8.2 8.2 -97 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 442 8 4 4 4.9 CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
56943515 112507 None 0 Human Functional pEC50 = 8.2 8.2 -7 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 478 13 6 7 3.7 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298213 112507 None 0 Human Functional pEC50 = 8.2 8.2 -7 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 478 13 6 7 3.7 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1 10.1016/j.bmcl.2014.04.095
11169365 112575 None 0 Human Functional pEC50 = 8.2 8.2 -22 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 502 11 6 7 4.0 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298986 112575 None 0 Human Functional pEC50 = 8.2 8.2 -22 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 502 11 6 7 4.0 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
164612262 188586 None 0 Human Functional pEC50 = 8.2 8.2 -190 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4853372 188586 None 0 Human Functional pEC50 = 8.2 8.2 -190 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028127 188586 None 0 Human Functional pEC50 = 8.2 8.2 -190 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
5493324 98956 None 24 Human Functional pEC50 = 8.2 8.2 -208 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 402 9 4 4 3.5 C[C@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
CHEMBL279260 98956 None 24 Human Functional pEC50 = 8.2 8.2 -208 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 402 9 4 4 3.5 C[C@H](Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
24822972 97584 None 0 Human Functional pEC50 = 8.2 8.2 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 425 9 3 4 4.6 COc1cc(CCNC[C@H](O)c2cccc(Cl)c2)ccc1-c1ccc(C(=O)O)cc1 10.1021/jm701324c
CHEMBL270460 97584 None 0 Human Functional pEC50 = 8.2 8.2 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 425 9 3 4 4.6 COc1cc(CCNC[C@H](O)c2cccc(Cl)c2)ccc1-c1ccc(C(=O)O)cc1 10.1021/jm701324c
52948056 17526 None 0 Human Functional pEC50 = 8.2 8.2 1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 478 8 2 7 4.5 OC(CNC1CCN(c2ncnc3scc(-c4ccc(F)cc4)c23)CC1)COc1ccccc1 10.1016/j.bmcl.2010.08.039
CHEMBL1257915 17526 None 0 Human Functional pEC50 = 8.2 8.2 1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 478 8 2 7 4.5 OC(CNC1CCN(c2ncnc3scc(-c4ccc(F)cc4)c23)CC1)COc1ccccc1 10.1016/j.bmcl.2010.08.039
45483844 200852 None 0 Human Functional pEC50 = 8.2 8.2 -4 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 398 7 4 5 3.5 CC(C)c1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.10.013
CHEMBL576848 200852 None 0 Human Functional pEC50 = 8.2 8.2 -4 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 398 7 4 5 3.5 CC(C)c1ccc(CC(C)(C)NCC(O)c2ccc(O)c3c2OCC(=O)N3)cc1 10.1016/j.bmcl.2009.10.013
155513474 169843 None 0 Human Functional pEC50 = 8.2 8.2 -83 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 478 8 4 4 5.1 CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4438531 169843 None 0 Human Functional pEC50 = 8.2 8.2 -83 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 478 8 4 4 5.1 CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
164618278 188634 None 0 Human Functional pEC50 = 8.2 8.2 -389 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4848018 188634 None 0 Human Functional pEC50 = 8.2 8.2 -389 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028489 188634 None 0 Human Functional pEC50 = 8.2 8.2 -389 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
45271518 197331 None 0 Human Functional pEC50 = 7.2 7.2 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 479 11 4 6 3.9 COC(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1203999 197331 None 0 Human Functional pEC50 = 7.2 7.2 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 479 11 4 6 3.9 COC(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL549689 197331 None 0 Human Functional pEC50 = 7.2 7.2 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 479 11 4 6 3.9 COC(=O)c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
45270690 197577 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 466 11 4 6 4.0 O=[N+]([O-])c1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1203994 197577 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 466 11 4 6 4.0 O=[N+]([O-])c1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL550037 197577 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 466 11 4 6 4.0 O=[N+]([O-])c1ccccc1NC(=S)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.06.031
45273281 198194 None 0 Human Functional pEC50 = 7.2 7.2 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 455 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2Cl)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL2448075 198194 None 0 Human Functional pEC50 = 7.2 7.2 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 455 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2Cl)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL557295 198194 None 0 Human Functional pEC50 = 7.2 7.2 -1 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 455 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2Cl)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
10008017 99926 None 10 Human Functional pEC50 = 7.2 7.2 -7 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 562 12 6 8 2.3 CC(C)C[C@H](NC(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1)C(=O)O 10.1021/jm000544b
CHEMBL285881 99926 None 10 Human Functional pEC50 = 7.2 7.2 -7 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 562 12 6 8 2.3 CC(C)C[C@H](NC(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1)C(=O)O 10.1021/jm000544b
44127782 199131 None 0 Human Functional pEC50 = 6.2 6.2 -1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 470 11 4 5 4.3 O=C(Cc1cccc2ccccc12)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL564556 199131 None 0 Human Functional pEC50 = 6.2 6.2 -1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 470 11 4 5 4.3 O=C(Cc1cccc2ccccc12)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
52944986 17620 None 0 Human Functional pEC50 = 6.2 6.2 -72 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 478 8 2 7 4.5 OC(CNC1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1)COc1ccccc1F 10.1016/j.bmcl.2010.08.039
CHEMBL1258257 17620 None 0 Human Functional pEC50 = 6.2 6.2 -72 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 478 8 2 7 4.5 OC(CNC1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1)COc1ccccc1F 10.1016/j.bmcl.2010.08.039
10187201 5183 None 0 Human Functional pEC50 = 6.2 6.2 -77 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 540 17 5 6 4.9 CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL106022 5183 None 0 Human Functional pEC50 = 6.2 6.2 -77 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 540 17 5 6 4.9 CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
44312924 164921 None 0 Human Functional pEC50 = 5.2 5.2 -123 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
ChEMBL 421 6 3 6 4.2 COc1cc(-c2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)cc(OC)c1OC 10.1016/s0960-894x(00)00459-5
CHEMBL421871 164921 None 0 Human Functional pEC50 = 5.2 5.2 -123 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
ChEMBL 421 6 3 6 4.2 COc1cc(-c2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)cc(OC)c1OC 10.1016/s0960-894x(00)00459-5
44219641 178544 None 0 Human Functional pEC50 = 7.2 7.2 -5 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 498 13 3 6 4.1 CC(Cc1ccc(NC(=O)Cc2nccn2Cc2ccccc2)cc1)NC[C@H](O)COc1ccccc1 10.1016/j.bmc.2009.03.044
CHEMBL466088 178544 None 0 Human Functional pEC50 = 7.2 7.2 -5 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 498 13 3 6 4.1 CC(Cc1ccc(NC(=O)Cc2nccn2Cc2ccccc2)cc1)NC[C@H](O)COc1ccccc1 10.1016/j.bmc.2009.03.044
24895791 186746 None 0 Human Functional pEC50 = 7.2 7.2 -199 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 419 10 3 4 4.7 CCOc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL488051 186746 None 0 Human Functional pEC50 = 7.2 7.2 -199 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 419 10 3 4 4.7 CCOc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
44580040 187226 None 0 Human Functional pEC50 = 6.2 6.2 -389 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 510 10 4 5 5.7 CC(C)(C)C(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
CHEMBL491645 187226 None 0 Human Functional pEC50 = 6.2 6.2 -389 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 510 10 4 5 5.7 CC(C)(C)C(=O)Nc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
24950560 172847 None 0 Human Functional pEC50 = 6.2 6.2 -16 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 421 6 3 3 4.9 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccccc2Cl)CC3)cc1 10.1021/jm800222k
CHEMBL450842 172847 None 0 Human Functional pEC50 = 6.2 6.2 -16 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 421 6 3 3 4.9 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccccc2Cl)CC3)cc1 10.1021/jm800222k
145984042 165770 None 0 Human Functional pEC50 = 5.2 5.2 -1348 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 475 13 4 5 3.1 CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)Cc3ccccc3)cc2)c1 10.1016/j.ejmech.2018.03.032
CHEMBL4244929 165770 None 0 Human Functional pEC50 = 5.2 5.2 -1348 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 475 13 4 5 3.1 CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)Cc3ccccc3)cc2)c1 10.1016/j.ejmech.2018.03.032
24824225 12827 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 454 11 3 5 4.4 CN(c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1)c1ccc(OCC(=O)O)cc1 10.1021/jm701324c
CHEMBL1188359 12827 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 454 11 3 5 4.4 CN(c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1)c1ccc(OCC(=O)O)cc1 10.1021/jm701324c
CHEMBL536108 12827 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 454 11 3 5 4.4 CN(c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1)c1ccc(OCC(=O)O)cc1 10.1021/jm701324c
10092953 98088 None 0 Human Functional pEC50 = 7.2 7.2 -34 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 409 8 3 3 4.9 Cc1cc(C(=O)O)ccc1-c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1 10.1021/jm701324c
CHEMBL273028 98088 None 0 Human Functional pEC50 = 7.2 7.2 -34 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 409 8 3 3 4.9 Cc1cc(C(=O)O)ccc1-c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1 10.1021/jm701324c
16049376 64122 None 0 Human Functional pEC50 = 7.2 7.2 -44 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 515 13 5 7 4.2 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3cccc(Cl)c3Cl)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807871 64122 None 0 Human Functional pEC50 = 7.2 7.2 -44 3
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 515 13 5 7 4.2 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3cccc(Cl)c3Cl)c2s1 10.1016/j.bmcl.2011.05.097
10238776 66497 None 0 Human Functional pEC50 = 7.2 7.2 -79 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 473 17 6 6 3.6 NC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1835853 66497 None 0 Human Functional pEC50 = 7.2 7.2 -79 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 473 17 6 6 3.6 NC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1852214 66497 None 0 Human Functional pEC50 = 7.2 7.2 -79 4
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 473 17 6 6 3.6 NC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
24900689 70387 None 0 Human Functional pEC50 = 7.2 7.2 -112 5
Binding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assayBinding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assay
ChEMBL 479 11 5 7 3.5 COc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
CHEMBL1945039 70387 None 0 Human Functional pEC50 = 7.2 7.2 -112 5
Binding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assayBinding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assay
ChEMBL 479 11 5 7 3.5 COc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
11002571 48113 None 0 Human Functional pEC50 = 6.2 6.2 1 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 348 8 4 4 3.2 C[C@H](CNc1ccc(C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
CHEMBL155092 48113 None 0 Human Functional pEC50 = 6.2 6.2 1 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 348 8 4 4 3.2 C[C@H](CNc1ccc(C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
10346448 119894 None 0 Human Functional pEC50 = 6.2 6.2 -891 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 515 11 4 6 3.8 Cc1ccc(S(=O)(=O)NC(=O)Cc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm0101500
CHEMBL348501 119894 None 0 Human Functional pEC50 = 6.2 6.2 -891 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 515 11 4 6 3.8 Cc1ccc(S(=O)(=O)NC(=O)Cc2ccc(NC[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm0101500
11647543 138323 None 0 Human Functional pEC50 = 6.2 6.2 -2511 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 424 9 4 4 4.8 C[C@H](CNc1cccc(-c2ccccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
CHEMBL377028 138323 None 0 Human Functional pEC50 = 6.2 6.2 -2511 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 424 9 4 4 4.8 C[C@H](CNc1cccc(-c2ccccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
145987168 167311 None 0 Human Functional pEC50 = 6.2 6.2 -316 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 4 5 2.1 COc1cccc(CCNC(CO)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2018.04.041
CHEMBL4291941 167311 None 0 Human Functional pEC50 = 6.2 6.2 -316 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 4 5 2.1 COc1cccc(CCNC(CO)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2018.04.041
42625897 12480 None 0 Human Functional pEC50 = 6.2 6.2 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 564 18 4 8 3.1 O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCOCC1 10.1021/jm801016j
CHEMBL1186265 12480 None 0 Human Functional pEC50 = 6.2 6.2 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 564 18 4 8 3.1 O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCOCC1 10.1021/jm801016j
CHEMBL456485 12480 None 0 Human Functional pEC50 = 6.2 6.2 -501 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 564 18 4 8 3.1 O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCOCC1 10.1021/jm801016j
42625821 12548 None 0 Human Functional pEC50 = 6.2 6.2 -630 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 522 18 4 7 3.4 CN(C)S(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1186678 12548 None 0 Human Functional pEC50 = 6.2 6.2 -630 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 522 18 4 7 3.4 CN(C)S(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL474393 12548 None 0 Human Functional pEC50 = 6.2 6.2 -630 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 522 18 4 7 3.4 CN(C)S(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
44237614 58251 None 0 Rat Functional pEC50 = 5.2 5.2 -31622 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 490 9 6 5 3.6 O=C(NCc1ccc(F)cc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682216 58251 None 0 Rat Functional pEC50 = 5.2 5.2 -31622 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 490 9 6 5 3.6 O=C(NCc1ccc(F)cc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
44331444 4271 None 0 Human Functional pEC50 = 5.2 5.2 -524 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 709 13 5 8 4.2 CC(C)N(Cc1cc(F)ccc1F)C(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1 10.1016/s0960-894x(02)00608-x
CHEMBL100589 4271 None 0 Human Functional pEC50 = 5.2 5.2 -524 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 709 13 5 8 4.2 CC(C)N(Cc1cc(F)ccc1F)C(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1 10.1016/s0960-894x(02)00608-x
24824226 97496 None 0 Human Functional pEC50 = 7.2 7.2 -1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 439 11 3 4 4.3 O=C(O)COc1ccc(Cc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
CHEMBL270027 97496 None 0 Human Functional pEC50 = 7.2 7.2 -1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 439 11 3 4 4.3 O=C(O)COc1ccc(Cc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
44579925 184431 None 0 Human Functional pEC50 = 7.2 7.2 -6 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 445 9 3 4 5.4 O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)ccc1Cl 10.1016/j.bmcl.2008.08.009
CHEMBL484265 184431 None 0 Human Functional pEC50 = 7.2 7.2 -6 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 445 9 3 4 5.4 O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)ccc1Cl 10.1016/j.bmcl.2008.08.009
45483849 199633 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 388 6 3 3 4.5 CC(C)(Cc1cc(F)cc(F)c1)NCC(O)c1cc(Cl)c(N)c(Cl)c1 10.1016/j.bmcl.2009.10.013
CHEMBL568060 199633 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 388 6 3 3 4.5 CC(C)(Cc1cc(F)cc(F)c1)NCC(O)c1cc(Cl)c(N)c(Cl)c1 10.1016/j.bmcl.2009.10.013
24936488 17656 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 414 7 3 8 2.7 Cc1csc2ncnc(N3CCC(NCC(O)COc4ccc(O)cc4)CC3)c12 10.1016/j.bmcl.2010.08.039
CHEMBL1258373 17656 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 414 7 3 8 2.7 Cc1csc2ncnc(N3CCC(NCC(O)COc4ccc(O)cc4)CC3)c12 10.1016/j.bmcl.2010.08.039
44574759 178673 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 470 12 3 6 3.6 O=C(Cc1nccn1-c1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL467082 178673 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 470 12 3 6 3.6 O=C(Cc1nccn1-c1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
24950570 175534 None 0 Human Functional pEC50 = 6.2 6.2 -794 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 439 6 3 3 5.0 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)cc1F 10.1021/jm800222k
CHEMBL457629 175534 None 0 Human Functional pEC50 = 6.2 6.2 -794 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 439 6 3 3 5.0 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)cc1F 10.1021/jm800222k
44396532 66777 None 0 Human Functional pEC50 = 7.2 7.2 -42 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 455 9 4 5 4.3 C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
CHEMBL185836 66777 None 0 Human Functional pEC50 = 7.2 7.2 -42 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 455 9 4 5 4.3 C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
44127478 197670 None 0 Human Functional pEC50 = 6.2 6.2 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 435 11 5 6 2.6 NC(C(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1 10.1016/j.ejmech.2009.01.022
CHEMBL550743 197670 None 0 Human Functional pEC50 = 6.2 6.2 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 435 11 5 6 2.6 NC(C(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccccc1 10.1016/j.ejmech.2009.01.022
2419 3463 None 53 Human Functional pEC50 = 7.2 7.2 -977 19
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/acs.jmedchem.0c01195
5152 3463 None 53 Human Functional pEC50 = 7.2 7.2 -977 19
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/acs.jmedchem.0c01195
5152.0 3463 None 53 Human Functional pEC50 = 7.2 7.2 -977 19
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/acs.jmedchem.0c01195
559 3463 None 53 Human Functional pEC50 = 7.2 7.2 -977 19
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/acs.jmedchem.0c01195
CHEMBL1263 3463 None 53 Human Functional pEC50 = 7.2 7.2 -977 19
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/acs.jmedchem.0c01195
DB00938 3463 None 53 Human Functional pEC50 = 7.2 7.2 -977 19
Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/acs.jmedchem.0c01195
24950053 188093 None 0 Human Functional pEC50 = 6.2 6.2 -117 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 443 7 3 5 5.1 O=C(O)c1ccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)s1 10.1021/jm800222k
CHEMBL497280 188093 None 0 Human Functional pEC50 = 6.2 6.2 -117 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 443 7 3 5 5.1 O=C(O)c1ccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)s1 10.1021/jm800222k
24950236 189181 None 0 Human Functional pEC50 = 7.2 7.2 -89 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 534 9 4 5 6.8 O=C(O)c1cc(NC2CCCCC2)cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)c1 10.1021/jm800222k
CHEMBL509729 189181 None 0 Human Functional pEC50 = 7.2 7.2 -89 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 534 9 4 5 6.8 O=C(O)c1cc(NC2CCCCC2)cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)c1 10.1021/jm800222k
44579649 187073 None 0 Human Functional pEC50 = 6.2 6.2 -12 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 408 10 3 6 3.4 COc1ccc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
CHEMBL490415 187073 None 0 Human Functional pEC50 = 6.2 6.2 -12 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 408 10 3 6 3.4 COc1ccc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
11224275 173598 None 0 Human Functional pEC50 = 6.2 6.2 -1621 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 433 11 3 4 5.1 CCCOc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL453048 173598 None 0 Human Functional pEC50 = 6.2 6.2 -1621 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 433 11 3 4 5.1 CCCOc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
45483839 199389 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 380 7 3 3 4.8 CCc1ccc(CC(C)(C)NCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1 10.1016/j.bmcl.2009.10.013
CHEMBL566353 199389 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 380 7 3 3 4.8 CCc1ccc(CC(C)(C)NCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1 10.1016/j.bmcl.2009.10.013
45483852 199213 None 0 Human Functional pEC50 = 8.1 8.1 -14 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 392 6 4 5 2.6 CC(C)(Cc1cc(F)cc(F)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL565267 199213 None 0 Human Functional pEC50 = 8.1 8.1 -14 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 392 6 4 5 2.6 CC(C)(Cc1cc(F)cc(F)c1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
155564766 175593 None 0 Human Functional pEC50 = 8.1 8.1 -181 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmc.2018.10.043
CHEMBL4577508 175593 None 0 Human Functional pEC50 = 8.1 8.1 -181 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmc.2018.10.043
12578 936 None 44 Human Functional pEC50 = 8.1 8.1 154 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 219 4 3 4 1.2 CC(C)NCC(C1=CC(=C(C=C1)N)C#N)O 10.1021/jm400348g
2755 936 None 44 Human Functional pEC50 = 8.1 8.1 154 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 219 4 3 4 1.2 CC(C)NCC(C1=CC(=C(C=C1)N)C#N)O 10.1021/jm400348g
CHEMBL1374751 936 None 44 Human Functional pEC50 = 8.1 8.1 154 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 219 4 3 4 1.2 CC(C)NCC(C1=CC(=C(C=C1)N)C#N)O 10.1021/jm400348g
164620479 188651 None 0 Human Functional pEC50 = 8.1 8.1 -288 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL4863847 188651 None 0 Human Functional pEC50 = 8.1 8.1 -288 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL5028596 188651 None 0 Human Functional pEC50 = 8.1 8.1 -288 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
145985242 165640 None 0 Human Functional pEC50 = 8.1 8.1 -6 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 443 11 4 4 3.9 O=C(Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1 10.1016/j.ejmech.2018.03.032
CHEMBL4241613 165640 None 0 Human Functional pEC50 = 8.1 8.1 -6 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 443 11 4 4 3.9 O=C(Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2cccc3[nH]ccc23)cc1 10.1016/j.ejmech.2018.03.032
164617235 188626 None 0 Human Functional pEC50 = 8.1 8.1 -251 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4848775 188626 None 0 Human Functional pEC50 = 8.1 8.1 -251 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028422 188626 None 0 Human Functional pEC50 = 8.1 8.1 -251 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
11810896 119546 None 0 Human Functional pEC50 = 8.1 8.1 -2 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 375 9 4 4 3.1 CC(=O)NCc1ccc(NC[C@@H](C)NC[C@H](O)c2cccc(Cl)c2)cc1 10.1021/jm0101500
CHEMBL345304 119546 None 0 Human Functional pEC50 = 8.1 8.1 -2 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 375 9 4 4 3.1 CC(=O)NCc1ccc(NC[C@@H](C)NC[C@H](O)c2cccc(Cl)c2)cc1 10.1021/jm0101500
1499 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.05.064
3779 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.05.064
3779.0 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.05.064
536 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.05.064
CHEMBL434 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.05.064
DB01064 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.05.064
9871386 112334 None 3 Human Functional pEC50 = 8.1 8.1 -35 4
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 521 10 5 6 5.5 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.095
CHEMBL3290999 112334 None 3 Human Functional pEC50 = 8.1 8.1 -35 4
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 521 10 5 6 5.5 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.095
66796015 112523 None 0 Human Functional pEC50 = 8.1 8.1 -35 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 474 11 6 7 3.2 NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298328 112523 None 0 Human Functional pEC50 = 8.1 8.1 -35 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 474 11 6 7 3.2 NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
56943518 112524 None 0 Human Functional pEC50 = 8.1 8.1 -25 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 488 12 6 7 3.6 NCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298329 112524 None 0 Human Functional pEC50 = 8.1 8.1 -25 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 488 12 6 7 3.6 NCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
56943545 112525 None 0 Human Functional pEC50 = 8.1 8.1 -28 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 502 13 6 7 4.0 NCCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298330 112525 None 0 Human Functional pEC50 = 8.1 8.1 -28 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 502 13 6 7 4.0 NCCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
56943546 112541 None 0 Human Functional pEC50 = 8.1 8.1 -25 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 518 14 6 8 3.2 NCCOCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298691 112541 None 0 Human Functional pEC50 = 8.1 8.1 -25 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 518 14 6 8 3.2 NCCOCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
56943517 112567 None 0 Human Functional pEC50 = 8.1 8.1 -3 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 621 13 5 9 2.8 CS(=O)(=O)N1CCN(CCOc2ccc(Nc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)ccc45)cc3)cc2)CC1 10.1016/j.bmcl.2014.04.095
CHEMBL3298832 112567 None 0 Human Functional pEC50 = 8.1 8.1 -3 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 621 13 5 9 2.8 CS(=O)(=O)N1CCN(CCOc2ccc(Nc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)ccc45)cc3)cc2)CC1 10.1016/j.bmcl.2014.04.095
1499 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.08.043
3779 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.08.043
3779.0 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.08.043
536 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.08.043
CHEMBL434 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.08.043
DB01064 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2011.08.043
56678973 66600 None 0 Human Functional pEC50 = 8.1 8.1 -7 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 555 18 6 6 5.6 O=C(Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCCC1 10.1016/j.bmc.2011.08.043
CHEMBL1835855 66600 None 0 Human Functional pEC50 = 8.1 8.1 -7 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 555 18 6 6 5.6 O=C(Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCCC1 10.1016/j.bmc.2011.08.043
CHEMBL1852541 66600 None 0 Human Functional pEC50 = 8.1 8.1 -7 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 555 18 6 6 5.6 O=C(Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCCC1 10.1016/j.bmc.2011.08.043
56658407 66659 None 0 Human Functional pEC50 = 8.1 8.1 -15 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 487 18 6 6 3.3 NC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1835857 66659 None 0 Human Functional pEC50 = 8.1 8.1 -15 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 487 18 6 6 3.3 NC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1852796 66659 None 0 Human Functional pEC50 = 8.1 8.1 -15 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 487 18 6 6 3.3 NC(=O)NCc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
1499 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm801016j
3779 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm801016j
3779.0 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm801016j
536 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm801016j
CHEMBL434 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm801016j
DB01064 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm801016j
1499 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm100326d
3779 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm100326d
3779.0 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm100326d
536 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm100326d
CHEMBL434 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm100326d
DB01064 2091 None 34 Human Functional pEC50 = 8.1 8.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm100326d
10225563 14214 None 0 Human Functional pEC50 = 8.1 8.1 -19 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 445 16 4 6 3.9 Cc1cc(C)cc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL1084891 14214 None 0 Human Functional pEC50 = 8.1 8.1 -19 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 445 16 4 6 3.9 Cc1cc(C)cc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL1198889 14214 None 0 Human Functional pEC50 = 8.1 8.1 -19 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 445 16 4 6 3.9 Cc1cc(C)cc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
9871386 112334 None 3 Human Functional pEC50 = 8.1 8.1 -35 4
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 521 10 5 6 5.5 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.069
CHEMBL3290999 112334 None 3 Human Functional pEC50 = 8.1 8.1 -35 4
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 521 10 5 6 5.5 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.069
45271517 197298 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 499 10 4 4 4.8 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Br)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1203998 197298 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 499 10 4 4 4.8 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Br)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL549487 197298 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 499 10 4 4 4.8 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(Br)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
45272431 197481 None 0 Human Functional pEC50 = 7.2 7.2 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 547 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(I)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1204002 197481 None 0 Human Functional pEC50 = 7.2 7.2 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 547 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(I)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL549960 197481 None 0 Human Functional pEC50 = 7.2 7.2 -6 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 547 10 4 4 4.7 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(I)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
44517694 197627 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 451 11 4 5 4.1 COc1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1 10.1016/j.bmc.2009.06.031
CHEMBL1203996 197627 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 451 11 4 5 4.1 COc1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1 10.1016/j.bmc.2009.06.031
CHEMBL550445 197627 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 451 11 4 5 4.1 COc1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1 10.1016/j.bmc.2009.06.031
44517696 198227 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 451 11 4 5 4.1 COc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1204007 198227 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 451 11 4 5 4.1 COc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL557705 198227 None 0 Human Functional pEC50 = 7.2 7.2 -3 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 451 11 4 5 4.1 COc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
24949891 188274 None 0 Human Functional pEC50 = 7.2 7.2 -46 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 438 7 3 5 4.4 O=C(O)c1ccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)nc1 10.1021/jm800222k
CHEMBL498703 188274 None 0 Human Functional pEC50 = 7.2 7.2 -46 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 438 7 3 5 4.4 O=C(O)c1ccc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)nc1 10.1021/jm800222k
24937269 17654 None 0 Human Functional pEC50 = 7.2 7.2 -2 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 490 9 3 8 3.8 OCc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1 10.1016/j.bmcl.2010.08.039
CHEMBL1258371 17654 None 0 Human Functional pEC50 = 7.2 7.2 -2 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 490 9 3 8 3.8 OCc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1 10.1016/j.bmcl.2010.08.039
44127481 198608 None 0 Human Functional pEC50 = 6.2 6.2 -1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 450 12 4 6 3.2 COc1cccc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)c1 10.1016/j.ejmech.2009.01.022
CHEMBL561211 198608 None 0 Human Functional pEC50 = 6.2 6.2 -1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 450 12 4 6 3.2 COc1cccc(CC(=O)Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)c1 10.1016/j.ejmech.2009.01.022
11189433 203340 None 0 Human Functional pEC50 = 6.2 6.2 -57 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 424 6 4 5 3.4 CC(C)(Cc1ccc(C(F)(F)F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL601430 203340 None 0 Human Functional pEC50 = 6.2 6.2 -57 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 424 6 4 5 3.4 CC(C)(Cc1ccc(C(F)(F)F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
44396779 67082 None 0 Human Functional pEC50 = 7.1 7.1 -17 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 611 12 4 8 5.1 C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3ccccc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
CHEMBL187209 67082 None 0 Human Functional pEC50 = 7.1 7.1 -17 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 611 12 4 8 5.1 C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3ccccc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
155551133 174100 None 0 Human Functional pEC50 = 7.1 7.1 -446 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 340 7 4 5 1.9 O=c1ccc2c(C(O)CNCCOc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4542430 174100 None 0 Human Functional pEC50 = 7.1 7.1 -446 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 340 7 4 5 1.9 O=c1ccc2c(C(O)CNCCOc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
24823127 97996 None 0 Human Functional pEC50 = 6.1 6.1 -724 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 453 10 3 4 5.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm701324c
CHEMBL272584 97996 None 0 Human Functional pEC50 = 6.1 6.1 -724 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 453 10 3 4 5.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm701324c
24823127 97996 None 0 Human Functional pEC50 = 6.1 6.1 -724 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 453 10 3 4 5.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1016/j.bmcl.2008.08.009
CHEMBL272584 97996 None 0 Human Functional pEC50 = 6.1 6.1 -724 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 453 10 3 4 5.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1016/j.bmcl.2008.08.009
44127050 199129 None 0 Human Functional pEC50 = 6.1 6.1 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 454 11 4 5 3.8 O=C(Cc1ccccc1Cl)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL564544 199129 None 0 Human Functional pEC50 = 6.1 6.1 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 454 11 4 5 3.8 O=C(Cc1ccccc1Cl)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
24823127 97996 None 0 Human Functional pEC50 = 6.1 6.1 -724 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 453 10 3 4 5.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL272584 97996 None 0 Human Functional pEC50 = 6.1 6.1 -724 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 453 10 3 4 5.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
24823127 97996 None 0 Human Functional pEC50 = 6.1 6.1 -724 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 453 10 3 4 5.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm9000709
CHEMBL272584 97996 None 0 Human Functional pEC50 = 6.1 6.1 -724 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 453 10 3 4 5.4 CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm9000709
44589400 194689 None 0 Human Functional pEC50 = 5.1 5.1 -3 3
Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor
ChEMBL 446 11 2 5 4.2 COc1ccc(CCNCC(O)COc2ccc3c(c2)CCCN3Cc2ccccc2)cc1 10.1016/j.bmc.2008.11.030
CHEMBL530556 194689 None 0 Human Functional pEC50 = 5.1 5.1 -3 3
Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor
ChEMBL 446 11 2 5 4.2 COc1ccc(CCNCC(O)COc2ccc3c(c2)CCCN3Cc2ccccc2)cc1 10.1016/j.bmc.2008.11.030
45271886 197771 None 0 Human Functional pEC50 = 7.1 7.1 -724 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
ChEMBL 508 11 3 5 4.5 CC(C)Cc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1016/j.bmcl.2009.06.083
CHEMBL551532 197771 None 0 Human Functional pEC50 = 7.1 7.1 -724 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
ChEMBL 508 11 3 5 4.5 CC(C)Cc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1016/j.bmcl.2009.06.083
42639806 12522 None 0 Human Functional pEC50 = 6.1 6.1 -40 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 468 10 3 6 2.9 COc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL1186584 12522 None 0 Human Functional pEC50 = 6.1 6.1 -40 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 468 10 3 6 2.9 COc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL470858 12522 None 0 Human Functional pEC50 = 6.1 6.1 -40 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 468 10 3 6 2.9 COc1cc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
44331346 210848 None 0 Human Functional pEC50 = 6.1 6.1 -120 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 638 17 5 8 4.2 CCCCCCCCC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1 10.1016/s0960-894x(02)00608-x
CHEMBL99599 210848 None 0 Human Functional pEC50 = 6.1 6.1 -120 3
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
ChEMBL 638 17 5 8 4.2 CCCCCCCCC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1 10.1016/s0960-894x(02)00608-x
172461665 196598 None 0 Human Functional pEC50 = 7.1 7.1 134 3
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 366 7 2 6 2.4 O[C@@H](CNCC1COc2ccccc2O1)COc1cccc2cnccc12 10.1016/j.ejmech.2022.114961
CHEMBL5427527 196598 None 0 Human Functional pEC50 = 7.1 7.1 134 3
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubationAgonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
ChEMBL 366 7 2 6 2.4 O[C@@H](CNCC1COc2ccccc2O1)COc1cccc2cnccc12 10.1016/j.ejmech.2022.114961
44560791 189205 None 0 Human Functional pEC50 = 7.1 7.1 -154 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 376 8 3 4 3.7 C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccnc1 10.1021/jm8000345
CHEMBL510102 189205 None 0 Human Functional pEC50 = 7.1 7.1 -154 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 376 8 3 4 3.7 C[C@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)NC[C@H](O)c1cccnc1 10.1021/jm8000345
42639808 12529 None 0 Human Functional pEC50 = 6.1 6.1 -1230 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 522 11 3 6 4.2 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCC1 10.1021/jm9000709
CHEMBL1186601 12529 None 0 Human Functional pEC50 = 6.1 6.1 -1230 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 522 11 3 6 4.2 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCC1 10.1021/jm9000709
CHEMBL472090 12529 None 0 Human Functional pEC50 = 6.1 6.1 -1230 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 522 11 3 6 4.2 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCC1 10.1021/jm9000709
10302915 5350 None 0 Human Functional pEC50 = 6.1 6.1 -23 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 554 12 5 6 4.0 O=C(NCc1c(F)cccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL106884 5350 None 0 Human Functional pEC50 = 6.1 6.1 -23 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 554 12 5 6 4.0 O=C(NCc1c(F)cccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
44127681 197672 None 0 Human Functional pEC50 = 6.1 6.1 2 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 420 11 4 5 3.1 O=C(Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL550746 197672 None 0 Human Functional pEC50 = 6.1 6.1 2 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 420 11 4 5 3.1 O=C(Cc1ccccc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
164623544 188681 None 0 Human Functional pEC50 = 7.1 7.1 -2754 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 406 7 4 4 3.5 O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL4872653 188681 None 0 Human Functional pEC50 = 7.1 7.1 -2754 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 406 7 4 4 3.5 O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL5028764 188681 None 0 Human Functional pEC50 = 7.1 7.1 -2754 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 406 7 4 4 3.5 O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
24949722 175635 None 0 Human Functional pEC50 = 6.1 6.1 -223 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 455 6 3 3 5.3 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(C(F)(F)F)cc2)CC3)cc1 10.1021/jm800222k
CHEMBL457839 175635 None 0 Human Functional pEC50 = 6.1 6.1 -223 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 455 6 3 3 5.3 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(C(F)(F)F)cc2)CC3)cc1 10.1021/jm800222k
11476004 173597 None 0 Human Functional pEC50 = 6.1 6.1 -954 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 433 10 3 4 5.1 CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL453047 173597 None 0 Human Functional pEC50 = 6.1 6.1 -954 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 433 10 3 4 5.1 CC(C)Oc1cc(-c2ccc(CCN[C@@H](C)[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
45269853 199024 None 0 Human Functional pEC50 = 4.1 4.1 -4 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 426 11 3 5 3.1 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL563872 199024 None 0 Human Functional pEC50 = 4.1 4.1 -4 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
ChEMBL 426 11 3 5 3.1 O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1)c1ccccc1 10.1016/j.bmc.2009.06.031
9799092 47320 None 0 Human Functional pEC50 = 7.1 7.1 -17 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 362 9 4 4 3.1 C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
CHEMBL154419 47320 None 0 Human Functional pEC50 = 7.1 7.1 -17 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 362 9 4 4 3.1 C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
9799092 47320 None 0 Human Functional pEC50 = 7.1 7.1 -17 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 362 9 4 4 3.1 C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
CHEMBL154419 47320 None 0 Human Functional pEC50 = 7.1 7.1 -17 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 362 9 4 4 3.1 C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
56678847 66398 None 0 Human Functional pEC50 = 7.1 7.1 -125 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 527 18 5 7 3.2 O=C1CN(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1 10.1016/j.bmc.2011.05.064
CHEMBL1814274 66398 None 0 Human Functional pEC50 = 7.1 7.1 -125 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 527 18 5 7 3.2 O=C1CN(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1 10.1016/j.bmc.2011.05.064
CHEMBL1851691 66398 None 0 Human Functional pEC50 = 7.1 7.1 -125 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 527 18 5 7 3.2 O=C1CN(Cc2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1 10.1016/j.bmc.2011.05.064
56678845 66427 None 0 Human Functional pEC50 = 7.1 7.1 -39 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CNC(=O)N1c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1016/j.bmc.2011.05.064
CHEMBL1814269 66427 None 0 Human Functional pEC50 = 7.1 7.1 -39 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CNC(=O)N1c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1016/j.bmc.2011.05.064
CHEMBL1851839 66427 None 0 Human Functional pEC50 = 7.1 7.1 -39 3
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CNC(=O)N1c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1016/j.bmc.2011.05.064
9871096 66671 None 0 Human Functional pEC50 = 7.1 7.1 -125 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CNC(=O)N1c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
CHEMBL1814268 66671 None 0 Human Functional pEC50 = 7.1 7.1 -125 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CNC(=O)N1c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
CHEMBL1852860 66671 None 0 Human Functional pEC50 = 7.1 7.1 -125 4
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 513 17 5 7 3.2 O=C1CNC(=O)N1c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
9799092 47320 None 0 Human Functional pEC50 = 7.1 7.1 -17 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 362 9 4 4 3.1 C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL154419 47320 None 0 Human Functional pEC50 = 7.1 7.1 -17 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 362 9 4 4 3.1 C[C@H](CNc1ccc(CC(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
44441229 93802 None 0 Human Functional pEC50 = 7.1 7.1 -100 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 431 9 4 6 4.3 C[C@H](CNc1cccc(-c2nc(C(=O)O)cs2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
CHEMBL247315 93802 None 0 Human Functional pEC50 = 7.1 7.1 -100 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 431 9 4 6 4.3 C[C@H](CNc1cccc(-c2nc(C(=O)O)cs2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1016/j.bmcl.2007.05.069
46833103 7415 None 0 Human Functional pEC50 = 7.1 7.1 -10 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 433 16 5 7 3.0 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2ccc(O)cc2)ccc1O 10.1021/jm100326d
CHEMBL1086535 7415 None 0 Human Functional pEC50 = 7.1 7.1 -10 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 433 16 5 7 3.0 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2ccc(O)cc2)ccc1O 10.1021/jm100326d
11060184 119794 None 0 Human Functional pEC50 = 6.1 6.1 -1000 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 501 11 4 6 3.5 C[C@H](CNc1ccc(CC(=O)NS(=O)(=O)c2ccccc2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
CHEMBL347616 119794 None 0 Human Functional pEC50 = 6.1 6.1 -1000 3
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
ChEMBL 501 11 4 6 3.5 C[C@H](CNc1ccc(CC(=O)NS(=O)(=O)c2ccccc2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
9823696 75802 None 0 Human Functional pEC50 = 6.1 6.1 -501 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 424 9 4 4 4.7 Cc1ccc(C(=O)O)cc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1 10.1021/jm0509445
CHEMBL204827 75802 None 0 Human Functional pEC50 = 6.1 6.1 -501 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 424 9 4 4 4.7 Cc1ccc(C(=O)O)cc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1 10.1021/jm0509445
11495581 77351 None 0 Human Functional pEC50 = 6.1 6.1 -25 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 425 9 4 5 4.2 C[C@H](CNc1cccc(-c2ncccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
CHEMBL208328 77351 None 0 Human Functional pEC50 = 6.1 6.1 -25 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 425 9 4 5 4.2 C[C@H](CNc1cccc(-c2ncccc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
11546349 141420 None 0 Human Functional pEC50 = 6.1 6.1 -25 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 424 9 4 4 4.8 C[C@H](CNc1cccc(-c2ccc(C(=O)O)cc2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
CHEMBL383511 141420 None 0 Human Functional pEC50 = 6.1 6.1 -25 3
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 424 9 4 4 4.8 C[C@H](CNc1cccc(-c2ccc(C(=O)O)cc2)c1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0509445
2419 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.05.097
5152 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.05.097
5152.0 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.05.097
559 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.05.097
CHEMBL1263 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.05.097
DB00938 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2011.05.097
2419 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
5152 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
5152.0 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
559 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
CHEMBL1263 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
DB00938 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
2419 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
5152 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
5152.0 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
559 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
CHEMBL1263 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
DB00938 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
2419 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
5152 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
5152.0 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
559 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
CHEMBL1263 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
DB00938 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
2419 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
5152 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
5152.0 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
559 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
CHEMBL1263 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
DB00938 3463 None 53 Human Functional pEC50 = 6.1 6.1 -977 19
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
10940242 165293 None 0 Human Functional pEC50 = 6.1 6.1 -79 3
Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 515 12 4 6 3.8 C[C@H](CNc1ccc(CCS(=O)(=O)NC(=O)c2ccccc2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
CHEMBL422876 165293 None 0 Human Functional pEC50 = 6.1 6.1 -79 3
Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 515 12 4 6 3.8 C[C@H](CNc1ccc(CCS(=O)(=O)NC(=O)c2ccccc2)cc1)NC[C@H](O)c1cccc(Cl)c1 10.1021/jm0101500
42625743 12605 None 0 Human Functional pEC50 = 4.1 4.1 -39 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCCCOCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1186943 12605 None 0 Human Functional pEC50 = 4.1 4.1 -39 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCCCOCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL483407 12605 None 0 Human Functional pEC50 = 4.1 4.1 -39 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCCCOCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
559929 4902 None 8 Guinea pig Functional pEC50 = 8.1 8.1 4 2
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 273 5 4 5 1.4 CC(C)(C)NCC(O)COc1ccc(O)c(O)c1F 10.1021/jm00107a027
CHEMBL10453 4902 None 8 Guinea pig Functional pEC50 = 8.1 8.1 4 2
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
ChEMBL 273 5 4 5 1.4 CC(C)(C)NCC(O)COc1ccc(O)c(O)c1F 10.1021/jm00107a027
44419332 141847 None 0 Human Functional pEC50 = 8.1 8.1 -1 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levelsAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levels
ChEMBL 505 11 4 8 2.5 Cn1c(=O)[nH]c2cccc(OC[C@@H](O)CNC(C)(C)Cc3ccc(Oc4ccc(C(N)=O)cn4)cc3)c21 10.1016/j.bmcl.2006.08.010
CHEMBL386016 141847 None 0 Human Functional pEC50 = 8.1 8.1 -1 3
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levelsAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levels
ChEMBL 505 11 4 8 2.5 Cn1c(=O)[nH]c2cccc(OC[C@@H](O)CNC(C)(C)Cc3ccc(Oc4ccc(C(N)=O)cn4)cc3)c21 10.1016/j.bmcl.2006.08.010
46889771 6996 None 0 Human Functional pEC50 = 7.1 7.1 1 3
Agonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayAgonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assay
ChEMBL 549 7 3 6 4.9 O=C1c2cccc3cc(O)cc(c23)C(=O)N1CC1CCN(CC(O)COc2cccc3[nH]c4ccccc4c23)CC1 10.1016/j.bmcl.2010.04.009
CHEMBL1084706 6996 None 0 Human Functional pEC50 = 7.1 7.1 1 3
Agonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayAgonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assay
ChEMBL 549 7 3 6 4.9 O=C1c2cccc3cc(O)cc(c23)C(=O)N1CC1CCN(CC(O)COc2cccc3[nH]c4ccccc4c23)CC1 10.1016/j.bmcl.2010.04.009
45268136 198841 None 0 Human Functional pEC50 = 7.1 7.1 -2 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 466 11 4 6 4.0 O=[N+]([O-])c1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1 10.1016/j.bmc.2009.06.031
CHEMBL1203989 198841 None 0 Human Functional pEC50 = 7.1 7.1 -2 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 466 11 4 6 4.0 O=[N+]([O-])c1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1 10.1016/j.bmc.2009.06.031
CHEMBL562669 198841 None 0 Human Functional pEC50 = 7.1 7.1 -2 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 466 11 4 6 4.0 O=[N+]([O-])c1cccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)c1 10.1016/j.bmc.2009.06.031
44560792 173492 None 0 Human Functional pEC50 = 7.1 7.1 -794 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 434 10 3 5 4.5 CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccnc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL452798 173492 None 0 Human Functional pEC50 = 7.1 7.1 -794 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 434 10 3 5 4.5 CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3cccnc3)cc2)ccc1C(=O)O 10.1021/jm8000345
24950718 176102 None 0 Human Functional pEC50 = 6.1 6.1 -398 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 435 6 3 3 5.2 Cc1cc(C(=O)O)ccc1-c1ccc2c(c1)C[C@@H](NC[C@H](O)c1ccc(Cl)cc1)CC2 10.1021/jm800222k
CHEMBL458927 176102 None 0 Human Functional pEC50 = 6.1 6.1 -398 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 435 6 3 3 5.2 Cc1cc(C(=O)O)ccc1-c1ccc2c(c1)C[C@@H](NC[C@H](O)c1ccc(Cl)cc1)CC2 10.1021/jm800222k
11272641 12447 None 0 Human Functional pEC50 = 6.1 6.1 -6165 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 537 11 3 7 4.0 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1 10.1021/jm9000709
CHEMBL1186009 12447 None 0 Human Functional pEC50 = 6.1 6.1 -6165 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 537 11 3 7 4.0 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1 10.1021/jm9000709
CHEMBL445481 12447 None 0 Human Functional pEC50 = 6.1 6.1 -6165 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 537 11 3 7 4.0 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1OC1CCCCC1 10.1021/jm9000709
25071020 193294 None 0 Human Functional pEC50 = 6.1 6.1 -251 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 469 11 3 5 5.5 CC(C)Oc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
CHEMBL523265 193294 None 0 Human Functional pEC50 = 6.1 6.1 -251 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 469 11 3 5 5.5 CC(C)Oc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O 10.1016/j.bmcl.2008.08.009
24949726 189649 None 0 Human Functional pEC50 = 6.1 6.1 -457 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 435 6 3 3 5.2 Cc1cc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)ccc1C(=O)O 10.1021/jm800222k
CHEMBL514265 189649 None 0 Human Functional pEC50 = 6.1 6.1 -457 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 435 6 3 3 5.2 Cc1cc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)ccc1C(=O)O 10.1021/jm800222k
44127479 198635 None 0 Human Functional pEC50 = 7.1 7.1 10 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 454 11 4 5 3.8 O=C(Cc1cccc(Cl)c1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL561348 198635 None 0 Human Functional pEC50 = 7.1 7.1 10 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 454 11 4 5 3.8 O=C(Cc1cccc(Cl)c1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
24895359 192603 None 0 Human Functional pEC50 = 7.1 7.1 -104 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 405 9 3 4 4.3 COc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL520903 192603 None 0 Human Functional pEC50 = 7.1 7.1 -104 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 405 9 3 4 4.3 COc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
145989075 167188 None 0 Human Functional pEC50 = 6.1 6.1 -524 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 324 6 4 4 2.1 O=c1ccc2c(C(CO)NCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2018.04.041
CHEMBL4289813 167188 None 0 Human Functional pEC50 = 6.1 6.1 -524 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 324 6 4 4 2.1 O=c1ccc2c(C(CO)NCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2018.04.041
145994130 167477 None 0 Human Functional pEC50 = 6.1 6.1 -83 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 338 7 4 4 2.5 O=c1ccc2c(C(CO)NCCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2018.04.041
CHEMBL4294937 167477 None 0 Human Functional pEC50 = 6.1 6.1 -83 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 338 7 4 4 2.5 O=c1ccc2c(C(CO)NCCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2018.04.041
24894315 173076 None 0 Human Functional pEC50 = 7.1 7.1 -165 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 469 11 3 5 5.2 CC(C)Oc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL451772 173076 None 0 Human Functional pEC50 = 7.1 7.1 -165 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 469 11 3 5 5.2 CC(C)Oc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O 10.1021/jm8000345
44580042 193208 None 0 Human Functional pEC50 = 6.1 6.1 -26 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 396 9 3 5 3.6 O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)ccc1F 10.1016/j.bmcl.2008.08.009
CHEMBL522641 193208 None 0 Human Functional pEC50 = 6.1 6.1 -26 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 396 9 3 5 3.6 O=C(O)c1cc(Oc2cccc(CCNC[C@H](O)c3cccnc3)c2)ccc1F 10.1016/j.bmcl.2008.08.009
42639491 12575 None 0 Human Functional pEC50 = 6.1 6.1 -1659 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 552 11 3 6 5.3 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1SC1CCCCC1 10.1021/jm9000709
CHEMBL1186805 12575 None 0 Human Functional pEC50 = 6.1 6.1 -1659 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 552 11 3 6 5.3 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1SC1CCCCC1 10.1021/jm9000709
CHEMBL479342 12575 None 0 Human Functional pEC50 = 6.1 6.1 -1659 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 552 11 3 6 5.3 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1SC1CCCCC1 10.1021/jm9000709
44396738 123951 None 0 Human Functional pEC50 = 7.1 7.1 -77 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 655 13 5 9 4.8 C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3ccc(C(=O)O)cc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
CHEMBL362763 123951 None 0 Human Functional pEC50 = 7.1 7.1 -77 3
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
ChEMBL 655 13 5 9 4.8 C[C@H](Cc1c[nH]c2c(OS(=O)(=O)c3ccc(C(=O)O)cc3)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccs2)c1 10.1016/j.bmcl.2004.10.035
10142284 4891 None 0 Human Functional pEC50 = 7.1 7.1 -1 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 510 11 5 6 3.9 O=C(NC1CCCCC1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL104481 4891 None 0 Human Functional pEC50 = 7.1 7.1 -1 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 510 11 5 6 3.9 O=C(NC1CCCCC1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
1239 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.10.013
3410 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.10.013
3410.0 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.10.013
3465 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.10.013
CHEMBL1256786 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.10.013
DB00983 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.10.013
1239 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.06.104
3410 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.06.104
3410.0 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.06.104
3465 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.06.104
CHEMBL1256786 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.06.104
DB00983 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.06.104
1239 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.12.087
3410 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.12.087
3410.0 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.12.087
3465 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.12.087
CHEMBL1256786 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.12.087
DB00983 1677 None 37 Human Functional pEC50 = 7.1 7.1 -67 6
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2009.12.087
24895361 185480 None 0 Human Functional pEC50 = 7.1 7.1 -933 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 433 10 3 4 5.1 CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
CHEMBL486051 185480 None 0 Human Functional pEC50 = 7.1 7.1 -933 3
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 433 10 3 4 5.1 CC(C)Oc1cc(-c2ccc(C[C@@H](C)NC[C@H](O)c3ccccc3)cc2)ccc1C(=O)O 10.1021/jm8000345
155550964 174054 None 0 Human Functional pEC50 = 7.1 7.1 -575 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 352 8 4 4 2.9 O=c1ccc2c(C(O)CNCCCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4541263 174054 None 0 Human Functional pEC50 = 7.1 7.1 -575 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 352 8 4 4 2.9 O=c1ccc2c(C(O)CNCCCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
10232593 5399 None 0 Human Functional pEC50 = 7.1 7.1 -1 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 609 17 6 7 4.8 CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)c4c3CCC(=O)N4)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL107129 5399 None 0 Human Functional pEC50 = 7.1 7.1 -1 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 609 17 6 7 4.8 CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)c4c3CCC(=O)N4)cc2)CC1 10.1016/s0960-894x(01)00645-x
9873245 4518 None 0 Human Functional pEC50 = 6.1 6.1 -38 3
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 590 17 5 7 4.3 CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
CHEMBL102194 4518 None 0 Human Functional pEC50 = 6.1 6.1 -38 3
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
ChEMBL 590 17 5 7 4.3 CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
10028830 2246 None 31 Human Functional pEC50 = 6.1 6.1 -186 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 497 13 4 6 2.7 O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1 10.1016/j.ejmech.2018.03.032
3932 2246 None 31 Human Functional pEC50 = 6.1 6.1 -186 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 497 13 4 6 2.7 O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1 10.1016/j.ejmech.2018.03.032
CHEMBL4238084 2246 None 31 Human Functional pEC50 = 6.1 6.1 -186 3
Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay
ChEMBL 497 13 4 6 2.7 O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1 10.1016/j.ejmech.2018.03.032
44237666 58253 None 0 Rat Functional pEC50 = 5.1 5.1 -44668 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 548 10 6 5 5.0 O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2010.12.096
CHEMBL1682218 58253 None 0 Rat Functional pEC50 = 5.1 5.1 -44668 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 548 10 6 5 5.0 O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2010.12.096
24950059 174974 None 0 Human Functional pEC50 = 6.1 6.1 -169 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 467 8 3 5 5.0 COc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1 10.1021/jm800222k
CHEMBL456352 174974 None 0 Human Functional pEC50 = 6.1 6.1 -169 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 467 8 3 5 5.0 COc1cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc(C(=O)O)c1 10.1021/jm800222k
24823466 12835 None 0 Human Functional pEC50 = 8.0 8.0 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 440 11 4 5 4.4 O=C(O)COc1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
CHEMBL1188436 12835 None 0 Human Functional pEC50 = 8.0 8.0 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 440 11 4 5 4.4 O=C(O)COc1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
CHEMBL536330 12835 None 0 Human Functional pEC50 = 8.0 8.0 1 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 440 11 4 5 4.4 O=C(O)COc1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1 10.1021/jm701324c
11270069 95754 None 0 Human Functional pEC50 = 8.0 8.0 6 2
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 328 6 3 2 4.1 C[C@@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
CHEMBL25823 95754 None 0 Human Functional pEC50 = 8.0 8.0 6 2
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 328 6 3 2 4.1 C[C@@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
52949488 17553 None 0 Human Functional pEC50 = 8.0 8.0 -3 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 490 9 2 8 4.4 COc1ccccc1OCC(O)CNC1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1 10.1016/j.bmcl.2010.08.039
CHEMBL1258023 17553 None 0 Human Functional pEC50 = 8.0 8.0 -3 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 490 9 2 8 4.4 COc1ccccc1OCC(O)CNC1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1 10.1016/j.bmcl.2010.08.039
155548071 173853 None 0 Human Functional pEC50 = 8.0 8.0 -131 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 338 7 4 4 2.5 O=c1ccc2c(C(O)CNCCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4536813 173853 None 0 Human Functional pEC50 = 8.0 8.0 -131 2
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 338 7 4 4 2.5 O=c1ccc2c(C(O)CNCCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
56598831 89177 None 0 Human Functional pEC50 = 8.0 8.0 1023 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 459 15 5 7 2.3 O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
CHEMBL2348220 89177 None 0 Human Functional pEC50 = 8.0 8.0 1023 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 459 15 5 7 2.3 O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
CHEMBL2365796 89177 None 0 Human Functional pEC50 = 8.0 8.0 1023 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 459 15 5 7 2.3 O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
45101522 201473 None 0 Human Functional pEC50 = 8 8.0 -5 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 578 15 7 9 2.0 CC(C)(Cc1ccc(NC(=O)CCCNCCCS(=O)(=O)O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL585751 201473 None 0 Human Functional pEC50 = 8 8.0 -5 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 578 15 7 9 2.0 CC(C)(Cc1ccc(NC(=O)CCCNCCCS(=O)(=O)O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
45272430 197900 None 0 Human Functional pEC50 = 7.1 7.1 -8 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 439 10 4 4 4.2 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(F)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1204001 197900 None 0 Human Functional pEC50 = 7.1 7.1 -8 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 439 10 4 4 4.2 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(F)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL552374 197900 None 0 Human Functional pEC50 = 7.1 7.1 -8 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 439 10 4 4 4.2 O[C@@H](CNCCc1ccc(NC(=S)Nc2ccc(F)cc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
44517692 199125 None 0 Human Functional pEC50 = 7.1 7.1 -4 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 466 11 4 6 4.0 O=[N+]([O-])c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL1203990 199125 None 0 Human Functional pEC50 = 7.1 7.1 -4 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 466 11 4 6 4.0 O=[N+]([O-])c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
CHEMBL564516 199125 None 0 Human Functional pEC50 = 7.1 7.1 -4 3
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 466 11 4 6 4.0 O=[N+]([O-])c1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1 10.1016/j.bmc.2009.06.031
44237612 58246 None 0 Rat Functional pEC50 = 6.1 6.1 -4466 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 472 9 6 5 3.4 O=C(NCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682211 58246 None 0 Rat Functional pEC50 = 6.1 6.1 -4466 2
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
ChEMBL 472 9 6 5 3.4 O=C(NCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
11398536 12479 None 0 Human Functional pEC50 = 6.1 6.1 -6309 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 535 11 4 6 4.7 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1NC1CCCCC1 10.1021/jm9000709
CHEMBL1186241 12479 None 0 Human Functional pEC50 = 6.1 6.1 -6309 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 535 11 4 6 4.7 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1NC1CCCCC1 10.1021/jm9000709
CHEMBL455773 12479 None 0 Human Functional pEC50 = 6.1 6.1 -6309 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 535 11 4 6 4.7 CS(=O)(=O)NC(=O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1NC1CCCCC1 10.1021/jm9000709
24895565 176800 None 0 Human Functional pEC50 = 7.0 7.0 -575 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 475 11 3 5 5.5 O=C(O)c1ccc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1 10.1021/jm8000345
CHEMBL459862 176800 None 0 Human Functional pEC50 = 7.0 7.0 -575 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 475 11 3 5 5.5 O=C(O)c1ccc(-c2ccc(OCCNC[C@H](O)c3ccccc3)cc2)cc1OC1CCCCC1 10.1021/jm8000345
44127167 198712 None 0 Human Functional pEC50 = 6.0 6.0 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 421 11 4 6 2.5 O=C(Cc1cccnc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL561818 198712 None 0 Human Functional pEC50 = 6.0 6.0 1 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 421 11 4 6 2.5 O=C(Cc1cccnc1)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
24949720 189631 None 0 Human Functional pEC50 = 6.0 6.0 -2398 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 421 6 3 3 4.9 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)cc1 10.1021/jm800222k
CHEMBL514102 189631 None 0 Human Functional pEC50 = 6.0 6.0 -2398 3
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 421 6 3 3 4.9 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)cc1 10.1021/jm800222k
44565907 193279 None 0 Human Functional pEC50 = 7.0 7.0 -138 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 498 11 4 8 2.3 CCOc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
CHEMBL523149 193279 None 0 Human Functional pEC50 = 7.0 7.0 -138 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 498 11 4 8 2.3 CCOc1cc(-c2ccc(CCNC[C@H](O)c3cnccc3N)cc2)ccc1C(=O)NS(C)(=O)=O 10.1021/jm9000709
10205463 5504 None 0 Human Functional pEC50 = 6.0 6.0 -10 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 470 11 5 6 3.0 CC(C)NC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
CHEMBL107633 5504 None 0 Human Functional pEC50 = 6.0 6.0 -10 2
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
ChEMBL 470 11 5 6 3.0 CC(C)NC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1 10.1016/s0960-894x(01)00645-x
44127052 198192 None 0 Human Functional pEC50 = 6.0 6.0 -2 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 450 12 4 6 3.2 COc1ccccc1CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
CHEMBL557269 198192 None 0 Human Functional pEC50 = 6.0 6.0 -2 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
ChEMBL 450 12 4 6 3.2 COc1ccccc1CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/j.ejmech.2009.01.022
44574758 178648 None 0 Human Functional pEC50 = 5.0 5.0 -18 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 394 11 4 5 2.2 O=C(Cc1ncc[nH]1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
CHEMBL466879 178648 None 0 Human Functional pEC50 = 5.0 5.0 -18 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 394 11 4 5 2.2 O=C(Cc1ncc[nH]1)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 10.1016/j.bmc.2009.03.044
9896817 102940 None 0 Human Functional pEC50 = 6.0 6.0 -22 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)c2)cc1 10.1016/s0960-894x(00)00459-5
CHEMBL305891 102940 None 0 Human Functional pEC50 = 6.0 6.0 -22 3
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)c2)cc1 10.1016/s0960-894x(00)00459-5
24823296 98085 None 0 Human Functional pEC50 = 6.0 6.0 -2884 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 453 10 3 4 5.7 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1Oc1ccccc1 10.1021/jm701324c
CHEMBL273006 98085 None 0 Human Functional pEC50 = 6.0 6.0 -2884 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 453 10 3 4 5.7 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1Oc1ccccc1 10.1021/jm701324c
24949883 176199 None 0 Human Functional pEC50 = 6.0 6.0 -691 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 439 6 3 3 5.0 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)c(F)c1 10.1021/jm800222k
CHEMBL459133 176199 None 0 Human Functional pEC50 = 6.0 6.0 -691 2
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 439 6 3 3 5.0 O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2ccc(Cl)cc2)CC3)c(F)c1 10.1021/jm800222k
24823296 98085 None 0 Human Functional pEC50 = 6.0 6.0 -2884 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 453 10 3 4 5.7 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1Oc1ccccc1 10.1021/jm9000709
CHEMBL273006 98085 None 0 Human Functional pEC50 = 6.0 6.0 -2884 2
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 453 10 3 4 5.7 O=C(O)c1ccc(-c2ccc(CCNC[C@H](O)c3ccccc3)cc2)cc1Oc1ccccc1 10.1021/jm9000709
10648298 99773 None 0 Human Functional pEC50 = 5.0 5.0 -251 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 477 10 5 7 2.1 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(CCC(=O)O)cc3)CC2)ccc1O 10.1021/jm000544b
CHEMBL284788 99773 None 0 Human Functional pEC50 = 5.0 5.0 -251 3
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
ChEMBL 477 10 5 7 2.1 CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(CCC(=O)O)cc3)CC2)ccc1O 10.1021/jm000544b
46232815 204138 None 0 Human Functional pEC50 = 6 6.0 5 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 412 6 4 5 3.7 CC(C)(Cc1ccc(C(C)(C)C)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
CHEMBL606208 204138 None 0 Human Functional pEC50 = 6 6.0 5 2
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 412 6 4 5 3.7 CC(C)(Cc1ccc(C(C)(C)C)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmcl.2009.12.087
9896817 102940 None 0 Human Functional pIC50 = 5 5.0 -22 3
Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)c2)cc1 10.1016/s0960-894x(00)00459-5
CHEMBL305891 102940 None 0 Human Functional pIC50 = 5 5.0 -22 3
Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)c2)cc1 10.1016/s0960-894x(00)00459-5
9962058 207240 None 0 Human Functional pIC50 = 4 4.0 -165 3
Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)cc2)cc1 10.1016/s0960-894x(00)00459-5
CHEMBL74860 207240 None 0 Human Functional pIC50 = 4 4.0 -165 3
Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)cc2)cc1 10.1016/s0960-894x(00)00459-5
53318280 58672 None 0 Human Functional pIC50 = 6.0 6.0 -95 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 623 11 3 6 7.2 O=S(=O)(Nc1ccc(CCNC[C@H](O)c2ccccc2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
CHEMBL1684578 58672 None 0 Human Functional pIC50 = 6.0 6.0 -95 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 623 11 3 6 7.2 O=S(=O)(Nc1ccc(CCNC[C@H](O)c2ccccc2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
11722516 90925 None 0 Guinea pig Functional pIC50 = 5.9 5.9 - 1
Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs
ChEMBL 303 9 2 4 2.2 COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1 10.1016/S0960-894X(97)00207-2
CHEMBL23929 90925 None 0 Guinea pig Functional pIC50 = 5.9 5.9 - 1
Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs
ChEMBL 303 9 2 4 2.2 COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1 10.1016/S0960-894X(97)00207-2
44268214 18576 None 0 Human Functional pIC50 = 7.8 7.8 4 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 331 10 3 5 2.4 COc1ccc(CCCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/s0960-894x(98)00169-3
CHEMBL12762 18576 None 0 Human Functional pIC50 = 7.8 7.8 4 3
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
ChEMBL 331 10 3 5 2.4 COc1ccc(CCCNC[C@H](O)COc2ccc(O)cc2)cc1 10.1016/s0960-894x(98)00169-3
53319639 58675 None 0 Human Functional pIC50 = 5.8 5.8 -1 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(CC2CC[C@H]([C@@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
CHEMBL1684582 58675 None 0 Human Functional pIC50 = 5.8 5.8 -1 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(CC2CC[C@H]([C@@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
145990586 166939 None 0 Human Functional pIC50 = 7.8 7.8 -1 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells assessed as decrease in isoproterenol-induced cAMP accumulation after 15 mins by HTRF assayAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells assessed as decrease in isoproterenol-induced cAMP accumulation after 15 mins by HTRF assay
ChEMBL 297 2 2 4 2.6 COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 10.1039/C7MD00656J
CHEMBL4285281 166939 None 0 Human Functional pIC50 = 7.8 7.8 -1 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells assessed as decrease in isoproterenol-induced cAMP accumulation after 15 mins by HTRF assayAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells assessed as decrease in isoproterenol-induced cAMP accumulation after 15 mins by HTRF assay
ChEMBL 297 2 2 4 2.6 COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 10.1039/C7MD00656J
53326196 58673 None 0 Human Functional pIC50 = 5.8 5.8 1 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(CC2CC[C@@H]([C@@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
CHEMBL1684580 58673 None 0 Human Functional pIC50 = 5.8 5.8 1 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(CC2CC[C@@H]([C@@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
567 725 None 16 Rat Functional pIC50 = 6.7 6.7 -186 7
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 363 9 3 4 3.1 C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O 10.1021/jm00094a025
9841972 725 None 16 Rat Functional pIC50 = 6.7 6.7 -186 7
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 363 9 3 4 3.1 C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O 10.1021/jm00094a025
CHEMBL284782 725 None 16 Rat Functional pIC50 = 6.7 6.7 -186 7
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 363 9 3 4 3.1 C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O 10.1021/jm00094a025
1786 2520 None 51 Guinea pig Functional pIC50 = 6.7 6.7 -4 7
Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
4171 2520 None 51 Guinea pig Functional pIC50 = 6.7 6.7 -4 7
Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
4171.0 2520 None 51 Guinea pig Functional pIC50 = 6.7 6.7 -4 7
Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
553 2520 None 51 Guinea pig Functional pIC50 = 6.7 6.7 -4 7
Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
CHEMBL13 2520 None 51 Guinea pig Functional pIC50 = 6.7 6.7 -4 7
Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
DB00264 2520 None 51 Guinea pig Functional pIC50 = 6.7 6.7 -4 7
Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigsTested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
127034967 136575 None 0 Human Functional pIC50 = 6.7 6.7 -1 3
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 260 5 2 4 1.6 CB1C=Cc2c(cccc2OCC(O)CN(C)C)N1 10.1021/acs.jmedchem.5b01088
CHEMBL3736156 136575 None 0 Human Functional pIC50 = 6.7 6.7 -1 3
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 260 5 2 4 1.6 CB1C=Cc2c(cccc2OCC(O)CN(C)C)N1 10.1021/acs.jmedchem.5b01088
53326839 58674 None 0 Human Functional pIC50 = 5.7 5.7 -26 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(CC2CC[C@@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
CHEMBL1684581 58674 None 0 Human Functional pIC50 = 5.7 5.7 -26 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(CC2CC[C@@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
11722516 90925 None 0 Guinea pig Functional pIC50 = 5.7 5.7 - 1
Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs
ChEMBL 303 9 2 4 2.2 COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1 10.1016/S0960-894X(97)00207-2
CHEMBL23929 90925 None 0 Guinea pig Functional pIC50 = 5.7 5.7 - 1
Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs
ChEMBL 303 9 2 4 2.2 COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1 10.1016/S0960-894X(97)00207-2
51346867 58676 None 0 Human Functional pIC50 = 5.7 5.7 -537 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
CHEMBL1684583 58676 None 0 Human Functional pIC50 = 5.7 5.7 -537 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
53326197 58677 None 0 Human Functional pIC50 = 6.6 6.6 -28 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(C[C@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
CHEMBL1684584 58677 None 0 Human Functional pIC50 = 6.6 6.6 -28 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(C[C@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
2303 3187 None 44 Human Functional pIC50 = 6.6 6.6 -6 20
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/acs.jmedchem.5b01088
4946 3187 None 44 Human Functional pIC50 = 6.6 6.6 -6 20
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/acs.jmedchem.5b01088
564 3187 None 44 Human Functional pIC50 = 6.6 6.6 -6 20
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/acs.jmedchem.5b01088
63 3187 None 44 Human Functional pIC50 = 6.6 6.6 -6 20
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/acs.jmedchem.5b01088
91536 3187 None 44 Human Functional pIC50 = 6.6 6.6 -6 20
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/acs.jmedchem.5b01088
CHEMBL27 3187 None 44 Human Functional pIC50 = 6.6 6.6 -6 20
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/acs.jmedchem.5b01088
CHEMBL452861 3187 None 44 Human Functional pIC50 = 6.6 6.6 -6 20
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/acs.jmedchem.5b01088
DB00571 3187 None 44 Human Functional pIC50 = 6.6 6.6 -6 20
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/acs.jmedchem.5b01088
9873245 4518 None 0 Human Functional pIC50 = 7.6 7.6 -38 3
Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorCompound was tested for the antagonistic activity against Beta-1 adrenergic receptor
ChEMBL 590 17 5 7 4.3 CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
CHEMBL102194 4518 None 0 Human Functional pIC50 = 7.6 7.6 -38 3
Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorCompound was tested for the antagonistic activity against Beta-1 adrenergic receptor
ChEMBL 590 17 5 7 4.3 CCCCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1 10.1016/s0960-894x(02)00607-8
14739907 164228 None 0 Human Functional pIC50 = 6.6 6.6 1 2
Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs
ChEMBL 367 10 2 6 2.6 Cc1cccc(OCC(O)CNCCOc2ccc(-n3ccnc3)cc2)c1 10.1021/jm00172a033
CHEMBL421005 164228 None 0 Human Functional pIC50 = 6.6 6.6 1 2
Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs
ChEMBL 367 10 2 6 2.6 Cc1cccc(OCC(O)CNCCOc2ccc(-n3ccnc3)cc2)c1 10.1021/jm00172a033
14739906 210146 None 0 Human Functional pIC50 = 6.6 6.6 16 2
Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs
ChEMBL 411 13 2 7 2.5 COCCc1ccc(OCC(O)CNCCOc2ccc(-n3ccnc3)cc2)cc1 10.1021/jm00172a033
CHEMBL95457 210146 None 0 Human Functional pIC50 = 6.6 6.6 16 2
Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs
ChEMBL 411 13 2 7 2.5 COCCc1ccc(OCC(O)CNCCOc2ccc(-n3ccnc3)cc2)cc1 10.1021/jm00172a033
53326195 58671 None 0 Human Functional pIC50 = 5.5 5.5 -194 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(CC2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
CHEMBL1684577 58671 None 0 Human Functional pIC50 = 5.5 5.5 -194 3
Agonist activity at human beta1 adrenergic receptorAgonist activity at human beta1 adrenergic receptor
ChEMBL 649 9 3 6 7.7 O=S(=O)(Nc1ccc(CC2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 10.1016/j.bmcl.2010.12.087
9853471 207312 None 0 Human Functional pIC50 = 5.5 5.5 -389 3
Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1 10.1016/s0960-894x(00)00459-5
CHEMBL75604 207312 None 0 Human Functional pIC50 = 5.5 5.5 -389 3
Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccc(CC4NCCc5cc(O)c(O)cc54)cc3)cc2)cc1 10.1016/s0960-894x(00)00459-5
146015362 947 None 12 Rat Functional pIC50 = 4.5 4.5 -53703 5
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 421 8 4 6 2.2 C[C@H](Cc1ccc2c(c1)OC(O2)(C(=O)O)C(=O)O)NC[C@@H](c1cccc(c1)Cl)O 10.1021/jm00094a025
3462 947 None 12 Rat Functional pIC50 = 4.5 4.5 -53703 5
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 421 8 4 6 2.2 C[C@H](Cc1ccc2c(c1)OC(O2)(C(=O)O)C(=O)O)NC[C@@H](c1cccc(c1)Cl)O 10.1021/jm00094a025
5486546 947 None 12 Rat Functional pIC50 = 4.5 4.5 -53703 5
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 421 8 4 6 2.2 C[C@H](Cc1ccc2c(c1)OC(O2)(C(=O)O)C(=O)O)NC[C@@H](c1cccc(c1)Cl)O 10.1021/jm00094a025
CHEMBL1204876 947 None 12 Rat Functional pIC50 = 4.5 4.5 -53703 5
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 421 8 4 6 2.2 C[C@H](Cc1ccc2c(c1)OC(O2)(C(=O)O)C(=O)O)NC[C@@H](c1cccc(c1)Cl)O 10.1021/jm00094a025
1786 2520 None 51 Guinea pig Functional pIC50 = 6.5 6.5 -4 7
Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
4171 2520 None 51 Guinea pig Functional pIC50 = 6.5 6.5 -4 7
Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
4171.0 2520 None 51 Guinea pig Functional pIC50 = 6.5 6.5 -4 7
Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
553 2520 None 51 Guinea pig Functional pIC50 = 6.5 6.5 -4 7
Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
CHEMBL13 2520 None 51 Guinea pig Functional pIC50 = 6.5 6.5 -4 7
Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
DB00264 2520 None 51 Guinea pig Functional pIC50 = 6.5 6.5 -4 7
Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigsTested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1016/S0960-894X(97)00207-2
3687256 6836 None 5 Human Functional pIC50 = 6.4 6.4 3 2
Antagonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assayAntagonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assay
ChEMBL 500 8 1 5 5.0 Cc1ccc(C(C)C)c(OCC(O)CN2CCC(CN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1 10.1016/j.bmcl.2010.04.009
CHEMBL1083994 6836 None 5 Human Functional pIC50 = 6.4 6.4 3 2
Antagonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assayAntagonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assay
ChEMBL 500 8 1 5 5.0 Cc1ccc(C(C)C)c(OCC(O)CN2CCC(CN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1 10.1016/j.bmcl.2010.04.009
14739905 210744 None 0 Human Functional pIC50 = 7.4 7.4 7 2
Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs
ChEMBL 353 10 2 6 2.3 OC(CNCCOc1ccc(-n2ccnc2)cc1)COc1ccccc1 10.1021/jm00172a033
CHEMBL98975 210744 None 0 Human Functional pIC50 = 7.4 7.4 7 2
Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs
ChEMBL 353 10 2 6 2.3 OC(CNCCOc1ccc(-n2ccnc2)cc1)COc1ccccc1 10.1021/jm00172a033
1499 2091 None 34 Rat Functional pIC50 = 8.3 8.3 -269 38
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00094a025
3779 2091 None 34 Rat Functional pIC50 = 8.3 8.3 -269 38
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00094a025
3779.0 2091 None 34 Rat Functional pIC50 = 8.3 8.3 -269 38
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00094a025
536 2091 None 34 Rat Functional pIC50 = 8.3 8.3 -269 38
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00094a025
CHEMBL434 2091 None 34 Rat Functional pIC50 = 8.3 8.3 -269 38
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00094a025
DB01064 2091 None 34 Rat Functional pIC50 = 8.3 8.3 -269 38
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm00094a025
14823035 141650 None 1 Rat Functional pIC50 = 6.3 6.3 -10 4
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 377 9 2 5 3.1 COC(=O)COc1ccc(C[C@@H](C)NC[C@H](O)c2cccc(Cl)c2)cc1 10.1021/jm00094a025
CHEMBL38486 141650 None 1 Rat Functional pIC50 = 6.3 6.3 -10 4
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscleIn vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
ChEMBL 377 9 2 5 3.1 COC(=O)COc1ccc(C[C@@H](C)NC[C@H](O)c2cccc(Cl)c2)cc1 10.1021/jm00094a025
14739908 107302 None 0 Human Functional pIC50 = 5.3 5.3 1 2
Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs
ChEMBL 416 10 3 7 1.9 CS(=O)(=O)Nc1ccc(C(O)CNCCOc2ccc(-n3ccnc3)cc2)cc1 10.1021/jm00172a033
CHEMBL316868 107302 None 0 Human Functional pIC50 = 5.3 5.3 1 2
Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsTested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogs
ChEMBL 416 10 3 7 1.9 CS(=O)(=O)Nc1ccc(C(O)CNCCOc2ccc(-n3ccnc3)cc2)cc1 10.1021/jm00172a033
44313150 103832 None 0 Human Functional pIC50 = 6.3 6.3 -6 3
Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)c2)cc1 10.1016/s0960-894x(00)00459-5
CHEMBL308868 103832 None 0 Human Functional pIC50 = 6.3 6.3 -6 3
Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol
ChEMBL 628 12 6 6 6.7 CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)c2)cc1 10.1016/s0960-894x(00)00459-5
65772 60423 None 5 Human Functional pIC50 = 8.2 8.2 -5 11
Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol
ChEMBL 345 5 3 6 2.6 COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC 10.1016/s0960-894x(00)00459-5
CHEMBL174984 60423 None 5 Human Functional pIC50 = 8.2 8.2 -5 11
Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindololCompound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta-1 adrenergic receptor (AR) in the presence of [125I]iodocyanopindolol
ChEMBL 345 5 3 6 2.6 COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC 10.1016/s0960-894x(00)00459-5
10283539 167968 None 0 Human Functional pIC50 = 5.2 5.2 -1479 3
Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorCompound was tested for the antagonistic activity against Beta-1 adrenergic receptor
ChEMBL 697 14 6 9 2.8 CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00607-8
CHEMBL431048 167968 None 0 Human Functional pIC50 = 5.2 5.2 -1479 3
Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorCompound was tested for the antagonistic activity against Beta-1 adrenergic receptor
ChEMBL 697 14 6 9 2.8 CS(=O)(=O)Nc1cc(OC[C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(NC(=O)NCc4cc(F)ccc4F)cc3)CC2)ccc1O 10.1016/s0960-894x(02)00607-8
127034966 136614 None 0 Human Functional pIC50 = 6.2 6.2 -1 2
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 260 5 2 4 1.6 CB1C=Cc2cccc(OCC(O)CN(C)C)c2N1 10.1021/acs.jmedchem.5b01088
CHEMBL3736433 136614 None 0 Human Functional pIC50 = 6.2 6.2 -1 2
Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayAntagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay
ChEMBL 260 5 2 4 1.6 CB1C=Cc2cccc(OCC(O)CN(C)C)c2N1 10.1021/acs.jmedchem.5b01088
187238 78149 None 6 Rat Functional pKd = 10.2 10.2 - 0
Antagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cells
ChEMBL 413 5 3 4 2.8 CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12 10.1021/jm050624l
CHEMBL210309 78149 None 6 Rat Functional pKd = 10.2 10.2 - 0
Antagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cells
ChEMBL 413 5 3 4 2.8 CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12 10.1021/jm050624l
187238 78149 None 6 Rat Functional pKd = 10.2 10.2 - 0
Antagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cells
ChEMBL 413 5 3 4 2.8 CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12 10.1021/jm050624l
CHEMBL210309 78149 None 6 Rat Functional pKd = 10.2 10.2 - 0
Antagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cells
ChEMBL 413 5 3 4 2.8 CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12 10.1021/jm050624l
187238 78149 None 6 Rat Functional pKd = 10.2 10.2 - 0
Antagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cellsAntagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cells
ChEMBL 413 5 3 4 2.8 CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12 10.1021/jm050624l
CHEMBL210309 78149 None 6 Rat Functional pKd = 10.2 10.2 - 0
Antagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cellsAntagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cells
ChEMBL 413 5 3 4 2.8 CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12 10.1021/jm050624l
187238 78149 None 6 Rat Functional pKd = 10.1 10.1 - 0
Antagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cells
ChEMBL 413 5 3 4 2.8 CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12 10.1021/jm050624l
CHEMBL210309 78149 None 6 Rat Functional pKd = 10.1 10.1 - 0
Antagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cells
ChEMBL 413 5 3 4 2.8 CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12 10.1021/jm050624l
13040915 102987 None 0 Guinea pig Functional pKd = 10 10.0 - 0
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3hAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h
ChEMBL 325 10 2 7 0.8 CCOC(=O)CCNCC(O)COc1ccccc1C(=O)OC 10.1021/jm00354a003
CHEMBL30622 102987 None 0 Guinea pig Functional pKd = 10 10.0 - 0
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3hAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h
ChEMBL 325 10 2 7 0.8 CCOC(=O)CCNCC(O)COc1ccccc1C(=O)OC 10.1021/jm00354a003
3047497 13404 None 5 Rat Functional pKd = 9.6 9.6 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 321 11 2 4 2.8 CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL1192675 13404 None 5 Rat Functional pKd = 9.6 9.6 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 321 11 2 4 2.8 CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL543955 13404 None 5 Rat Functional pKd = 9.6 9.6 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 321 11 2 4 2.8 CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
3047497 13404 None 5 Rat Functional pKd = 9.6 9.6 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 321 11 2 4 2.8 CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL1192675 13404 None 5 Rat Functional pKd = 9.6 9.6 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 321 11 2 4 2.8 CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL543955 13404 None 5 Rat Functional pKd = 9.6 9.6 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 321 11 2 4 2.8 CC(C)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
187238 78149 None 6 Rat Functional pKd = 9.5 9.5 - 0
Antagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cells
ChEMBL 413 5 3 4 2.8 CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12 10.1021/jm050624l
CHEMBL210309 78149 None 6 Rat Functional pKd = 9.5 9.5 - 0
Antagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cellsAntagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cells
ChEMBL 413 5 3 4 2.8 CC(C)(C)NCC(O)COc1cccc2[nH]c(C#N)c(I)c12 10.1021/jm050624l
2685 890 None 19 Human Functional pKd = 9.5 9.5 - 1
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 494 11 4 8 2.3 OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O 10.1021/jm400348g
541 890 None 19 Human Functional pKd = 9.5 9.5 - 1
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 494 11 4 8 2.3 OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O 10.1021/jm400348g
CHEMBL280822 890 None 19 Human Functional pKd = 9.5 9.5 - 1
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 494 11 4 8 2.3 OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O 10.1021/jm400348g
123686 1981 None 38 Human Functional pKd = 9.5 9.5 74 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 354 9 4 5 1.7 C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O 10.1021/jm400348g
12581 1981 None 38 Human Functional pKd = 9.5 9.5 74 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 354 9 4 5 1.7 C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O 10.1021/jm400348g
CHEMBL11268 1981 None 38 Human Functional pKd = 9.5 9.5 74 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 354 9 4 5 1.7 C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O 10.1021/jm400348g
33624 3821 None 21 Guinea pig Functional pKd = 9.4 9.4 - 6
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1021/jm00350a009
33624.0 3821 None 21 Guinea pig Functional pKd = 9.4 9.4 - 6
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1021/jm00350a009
4061 3821 None 21 Guinea pig Functional pKd = 9.4 9.4 - 6
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1021/jm00350a009
565 3821 None 21 Guinea pig Functional pKd = 9.4 9.4 - 6
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1021/jm00350a009
CHEMBL499 3821 None 21 Guinea pig Functional pKd = 9.4 9.4 - 6
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1021/jm00350a009
DB00373 3821 None 21 Guinea pig Functional pKd = 9.4 9.4 - 6
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1021/jm00350a009
13187527 97144 None 0 Rat Functional pKd = 9.3 9.3 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 321 10 2 4 2.9 CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1 10.1021/jm00389a008
CHEMBL267375 97144 None 0 Rat Functional pKd = 9.3 9.3 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 321 10 2 4 2.9 CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1 10.1021/jm00389a008
CHEMBL542536 97144 None 0 Rat Functional pKd = 9.3 9.3 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 321 10 2 4 2.9 CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1 10.1021/jm00389a008
56598832 88302 None 0 Human Functional pKd = 9 9.0 4365 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 527 16 5 7 3.3 O=C(NCCNCC(O)COc1ccc(OCCOCCc2ccc(F)cc2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
CHEMBL2348218 88302 None 0 Human Functional pKd = 9 9.0 4365 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 527 16 5 7 3.3 O=C(NCCNCC(O)COc1ccc(OCCOCCc2ccc(F)cc2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
2685 890 None 19 Human Functional pKd = 9.0 9.0 - 1
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 494 11 4 8 2.3 OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O 10.1016/j.ejmech.2022.114961
541 890 None 19 Human Functional pKd = 9.0 9.0 - 1
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 494 11 4 8 2.3 OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O 10.1016/j.ejmech.2022.114961
CHEMBL280822 890 None 19 Human Functional pKd = 9.0 9.0 - 1
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 494 11 4 8 2.3 OC(COc1ccc(cc1)c1nc(cn1C)C(F)(F)F)CNCCOc1ccc(c(c1)C(=O)N)O 10.1016/j.ejmech.2022.114961
66653268 88285 None 0 Human Functional pKd = 8.8 8.8 3311 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 491 14 4 6 3.8 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1cccc(Cl)c1 10.1021/jm400348g
CHEMBL2348201 88285 None 0 Human Functional pKd = 8.8 8.8 3311 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 491 14 4 6 3.8 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1cccc(Cl)c1 10.1021/jm400348g
5311116 2334 None 9 Human Functional pKd = 8.8 8.8 4365 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 484 15 5 8 2.2 N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O 10.1021/jm400348g
544 2334 None 9 Human Functional pKd = 8.8 8.8 4365 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 484 15 5 8 2.2 N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O 10.1021/jm400348g
CHEMBL207802 2334 None 9 Human Functional pKd = 8.8 8.8 4365 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 484 15 5 8 2.2 N#Cc1cc(OCCOCC2CC2)ccc1OCC(CNCCNC(=O)Nc1ccc(cc1)O)O 10.1021/jm400348g
2303 3187 None 44 Human Functional pKd = 8.7 8.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
4946 3187 None 44 Human Functional pKd = 8.7 8.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
564 3187 None 44 Human Functional pKd = 8.7 8.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
63 3187 None 44 Human Functional pKd = 8.7 8.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
91536 3187 None 44 Human Functional pKd = 8.7 8.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
CHEMBL27 3187 None 44 Human Functional pKd = 8.7 8.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
CHEMBL452861 3187 None 44 Human Functional pKd = 8.7 8.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
DB00571 3187 None 44 Human Functional pKd = 8.7 8.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
12733305 60407 None 0 Guinea pig Functional pKd = 8.7 8.7 - 0
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 357 8 2 6 2.5 COc1ccc(CCNCC(O)C2=COc3ccccc3O2)cc1OC 10.1021/jm00140a015
CHEMBL174853 60407 None 0 Guinea pig Functional pKd = 8.7 8.7 - 0
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 357 8 2 6 2.5 COc1ccc(CCNCC(O)C2=COc3ccccc3O2)cc1OC 10.1021/jm00140a015
13187527 97144 None 0 Rat Functional pKd = 8.7 8.7 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 321 10 2 4 2.9 CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1 10.1021/jm00389a008
CHEMBL267375 97144 None 0 Rat Functional pKd = 8.7 8.7 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 321 10 2 4 2.9 CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1 10.1021/jm00389a008
CHEMBL542536 97144 None 0 Rat Functional pKd = 8.7 8.7 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 321 10 2 4 2.9 CC(C)NCC(O)COc1ccc(CCOC2CCCC2)cc1 10.1021/jm00389a008
44288749 164365 None 0 Rat Functional pKd = 8.0 8.0 - 0
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 330 8 2 4 4.0 CC(C)(C)c1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1 10.1021/jm970338c
CHEMBL42117 164365 None 0 Rat Functional pKd = 8.0 8.0 - 0
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 330 8 2 4 4.0 CC(C)(C)c1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1 10.1021/jm970338c
44288749 164365 None 0 Rat Functional pKd = 8.0 8.0 - 0
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 330 8 2 4 4.0 CC(C)(C)c1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1 10.1021/jm970338c
CHEMBL42117 164365 None 0 Rat Functional pKd = 8.0 8.0 - 0
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 330 8 2 4 4.0 CC(C)(C)c1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1 10.1021/jm970338c
11722868 104434 None 0 Guinea pig Functional pKd = 7 7.0 - 0
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 minAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 min
ChEMBL 309 8 2 5 1.9 COC(=O)CCc1ccc(OCC(O)CNC(C)(C)C)cc1 10.1021/jm00354a003
CHEMBL31025 104434 None 0 Guinea pig Functional pKd = 7 7.0 - 0
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 minAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 min
ChEMBL 309 8 2 5 1.9 COC(=O)CCc1ccc(OCC(O)CNC(C)(C)C)cc1 10.1021/jm00354a003
13040919 106123 None 0 Guinea pig Functional pKd = 5 5.0 - 0
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3hAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h
ChEMBL 339 9 2 7 1.1 CCOC(=O)C(C)(C)NCC(O)COc1ccccc1C(=O)OC 10.1021/jm00354a003
CHEMBL31335 106123 None 0 Guinea pig Functional pKd = 5 5.0 - 0
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3hAbility to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h
ChEMBL 339 9 2 7 1.1 CCOC(=O)C(C)(C)NCC(O)COc1ccccc1C(=O)OC 10.1021/jm00354a003
172461665 196598 None 0 Human Functional pKd = 7.0 7.0 134 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 366 7 2 6 2.4 O[C@@H](CNCC1COc2ccccc2O1)COc1cccc2cnccc12 10.1016/j.ejmech.2022.114961
CHEMBL5427527 196598 None 0 Human Functional pKd = 7.0 7.0 134 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 366 7 2 6 2.4 O[C@@H](CNCC1COc2ccccc2O1)COc1cccc2cnccc12 10.1016/j.ejmech.2022.114961
44371562 49732 None 0 Guinea pig Functional pKd = 5.0 5.0 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 257 7 2 5 1.2 CC(C)NCC(O)COC(=O)Cc1cccs1 10.1021/jm00387a006
CHEMBL156683 49732 None 0 Guinea pig Functional pKd = 5.0 5.0 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 257 7 2 5 1.2 CC(C)NCC(O)COC(=O)Cc1cccs1 10.1021/jm00387a006
20554487 13304 None 0 Rat Functional pKd = 7.9 7.9 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 369 11 2 5 2.2 CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCC2)cc1 10.1021/jm00389a008
CHEMBL1191855 13304 None 0 Rat Functional pKd = 7.9 7.9 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 369 11 2 5 2.2 CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCC2)cc1 10.1021/jm00389a008
CHEMBL543011 13304 None 0 Rat Functional pKd = 7.9 7.9 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 369 11 2 5 2.2 CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCC2)cc1 10.1021/jm00389a008
54757126 65514 None 0 Human Functional pKd = 7.0 7.0 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 893 26 4 10 6.8 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
CHEMBL1830492 65514 None 0 Human Functional pKd = 7.0 7.0 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 893 26 4 10 6.8 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
14856222 172752 None 0 Guinea pig Functional pKd = 4.9 4.9 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 217 5 2 4 0.9 CC(C)C(=O)OCC(O)CNC(C)(C)C 10.1021/jm00387a006
CHEMBL449651 172752 None 0 Guinea pig Functional pKd = 4.9 4.9 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 217 5 2 4 0.9 CC(C)C(=O)OCC(O)CNC(C)(C)C 10.1021/jm00387a006
12733304 128304 None 0 Guinea pig Functional pKd = 5.9 5.9 - 0
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 275 3 1 4 2.5 OC(CN1CCCCCC1)C1=COc2ccccc2O1 10.1021/jm00140a015
CHEMBL366558 128304 None 0 Guinea pig Functional pKd = 5.9 5.9 - 0
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 275 3 1 4 2.5 OC(CN1CCCCCC1)C1=COc2ccccc2O1 10.1021/jm00140a015
44288217 155243 None 0 Rat Functional pKd = 7.9 7.9 - 0
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 288 8 2 4 3.0 Cc1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1 10.1021/jm970338c
CHEMBL40217 155243 None 0 Rat Functional pKd = 7.9 7.9 - 0
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 288 8 2 4 3.0 Cc1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1 10.1021/jm970338c
2303 3187 None 44 Guinea pig Functional pKd = 7.9 7.9 -21 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
4946 3187 None 44 Guinea pig Functional pKd = 7.9 7.9 -21 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
564 3187 None 44 Guinea pig Functional pKd = 7.9 7.9 -21 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
63 3187 None 44 Guinea pig Functional pKd = 7.9 7.9 -21 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
91536 3187 None 44 Guinea pig Functional pKd = 7.9 7.9 -21 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
CHEMBL27 3187 None 44 Guinea pig Functional pKd = 7.9 7.9 -21 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
CHEMBL452861 3187 None 44 Guinea pig Functional pKd = 7.9 7.9 -21 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
DB00571 3187 None 44 Guinea pig Functional pKd = 7.9 7.9 -21 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
44371486 14251 None 0 Guinea pig Functional pKd = 6.9 6.9 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 230 7 2 4 1.9 CCC/C(C)=N\OCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL1161387 14251 None 0 Guinea pig Functional pKd = 6.9 6.9 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 230 7 2 4 1.9 CCC/C(C)=N\OCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL1199437 14251 None 0 Guinea pig Functional pKd = 6.9 6.9 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 230 7 2 4 1.9 CCC/C(C)=N\OCC(O)CNC(C)(C)C 10.1021/jm00180a007
54757229 65536 None 0 Human Functional pKd = 6.9 6.9 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 795 22 4 8 6.3 C=CCc1ccccc1OCC(O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1 10.1021/jm2008562
CHEMBL1830617 65536 None 0 Human Functional pKd = 6.9 6.9 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 795 22 4 8 6.3 C=CCc1ccccc1OCC(O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1 10.1021/jm2008562
3682 189546 None 13 Human Functional pKd = 6.9 6.9 - 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 277 6 2 3 2.6 Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2 10.1016/j.ejmech.2022.114961
CHEMBL1256784 189546 None 13 Human Functional pKd = 6.9 6.9 - 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 277 6 2 3 2.6 Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2 10.1016/j.ejmech.2022.114961
CHEMBL513389 189546 None 13 Human Functional pKd = 6.9 6.9 - 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 277 6 2 3 2.6 Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2 10.1016/j.ejmech.2022.114961
44371537 50684 None 0 Guinea pig Functional pKd = 4.9 4.9 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 243 6 2 4 1.5 CC(C)NCC(O)COC(=O)C1CCCCC1 10.1021/jm00387a006
CHEMBL157557 50684 None 0 Guinea pig Functional pKd = 4.9 4.9 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 243 6 2 4 1.5 CC(C)NCC(O)COC(=O)C1CCCCC1 10.1021/jm00387a006
12348305 97049 None 0 Guinea pig Functional pKd = 6.9 6.9 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 281 6 2 6 0.9 CC(C)NCC(O)COC(=O)c1ccc2c(c1)OCO2 10.1021/jm00387a006
CHEMBL266548 97049 None 0 Guinea pig Functional pKd = 6.9 6.9 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 281 6 2 6 0.9 CC(C)NCC(O)COC(=O)c1ccc2c(c1)OCO2 10.1021/jm00387a006
2369 622 None 46 Rat Functional pKd = 6.9 6.9 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
2369.0 622 None 46 Rat Functional pKd = 6.9 6.9 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
356 622 None 46 Rat Functional pKd = 6.9 6.9 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
549 622 None 46 Rat Functional pKd = 6.9 6.9 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
CHEMBL423 622 None 46 Rat Functional pKd = 6.9 6.9 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
DB00195 622 None 46 Rat Functional pKd = 6.9 6.9 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
12606708 13085 None 0 Guinea pig Functional pKd = 5.9 5.9 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 282 6 2 4 2.6 CC(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C 10.1021/jm00180a007
CHEMBL1190195 13085 None 0 Guinea pig Functional pKd = 5.9 5.9 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 282 6 2 4 2.6 CC(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C 10.1021/jm00180a007
CHEMBL540337 13085 None 0 Guinea pig Functional pKd = 5.9 5.9 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 282 6 2 4 2.6 CC(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C 10.1021/jm00180a007
44287476 12016 None 0 Guinea pig Functional pKd = 5.9 5.9 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 230 7 2 4 1.9 CCC(CC)=NOCC(O)CNC(C)(C)C 10.1021/jm00380a001
CHEMBL1183311 12016 None 0 Guinea pig Functional pKd = 5.9 5.9 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 230 7 2 4 1.9 CCC(CC)=NOCC(O)CNC(C)(C)C 10.1021/jm00380a001
CHEMBL289858 12016 None 0 Guinea pig Functional pKd = 5.9 5.9 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 230 7 2 4 1.9 CCC(CC)=NOCC(O)CNC(C)(C)C 10.1021/jm00380a001
3047527 206080 None 0 Rat Functional pKd = 6.9 6.9 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 335 11 2 4 3.2 CC(C)NCC(O)COc1ccc(CCOCC2CCCC2)cc1 10.1021/jm00389a008
CHEMBL6712 206080 None 0 Rat Functional pKd = 6.9 6.9 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 335 11 2 4 3.2 CC(C)NCC(O)COc1ccc(CCOCC2CCCC2)cc1 10.1021/jm00389a008
2447486 63080 None 0 Guinea pig Functional pKd = 7.9 7.9 - 2
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 324 5 2 4 3.2 CC(C)(C)NC[C@@H](O)CON=C1c2ccccc2-c2ccccc21 10.1021/jm00350a009
CHEMBL1788270 63080 None 0 Guinea pig Functional pKd = 7.9 7.9 - 2
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 324 5 2 4 3.2 CC(C)(C)NC[C@@H](O)CON=C1c2ccccc2-c2ccccc21 10.1021/jm00350a009
54756927 65508 None 0 Human Functional pKd = 7.9 7.9 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 833 22 4 8 7.5 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNC[C@H](O)COc1cccc2ccccc12 10.1021/jm2008562
CHEMBL1830486 65508 None 0 Human Functional pKd = 7.9 7.9 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 833 22 4 8 7.5 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNC[C@H](O)COc1cccc2ccccc12 10.1021/jm2008562
44288217 155243 None 0 Rat Functional pKd = 7.9 7.9 - 0
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 288 8 2 4 3.0 Cc1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1 10.1021/jm970338c
CHEMBL40217 155243 None 0 Rat Functional pKd = 7.9 7.9 - 0
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 288 8 2 4 3.0 Cc1ccc(NCC(O)CON=C(C2CC2)C2CC2)cc1 10.1021/jm970338c
172446785 195127 None 0 Human Functional pKd = 6.9 6.9 -2 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 389 11 2 3 4.8 CCc1ccccc1OC[C@@H](O)CNCCC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2022.114961
CHEMBL5397120 195127 None 0 Human Functional pKd = 6.9 6.9 -2 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 389 11 2 3 4.8 CCc1ccccc1OC[C@@H](O)CNCCC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2022.114961
12606686 92912 None 0 Guinea pig Functional pKd = 4.9 4.9 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 189 5 2 3 1.2 CC(C)OCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL1161385 92912 None 0 Guinea pig Functional pKd = 4.9 4.9 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 189 5 2 3 1.2 CC(C)OCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL24391 92912 None 0 Guinea pig Functional pKd = 4.9 4.9 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 189 5 2 3 1.2 CC(C)OCC(O)CNC(C)(C)C 10.1021/jm00180a007
1786 2520 None 51 Guinea pig Functional pKd = 7.8 7.8 -4 7
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00350a009
4171 2520 None 51 Guinea pig Functional pKd = 7.8 7.8 -4 7
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00350a009
4171.0 2520 None 51 Guinea pig Functional pKd = 7.8 7.8 -4 7
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00350a009
553 2520 None 51 Guinea pig Functional pKd = 7.8 7.8 -4 7
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00350a009
CHEMBL13 2520 None 51 Guinea pig Functional pKd = 7.8 7.8 -4 7
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00350a009
DB00264 2520 None 51 Guinea pig Functional pKd = 7.8 7.8 -4 7
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00350a009
12733308 122617 None 0 Guinea pig Functional pKd = 6.8 6.8 - 0
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 393 4 2 7 3.1 Oc1nc2ccccc2n1C1CCN(CC(O)C2=COc3ccccc3O2)CC1 10.1021/jm00140a015
CHEMBL360139 122617 None 0 Guinea pig Functional pKd = 6.8 6.8 - 0
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 393 4 2 7 3.1 Oc1nc2ccccc2n1C1CCN(CC(O)C2=COc3ccccc3O2)CC1 10.1021/jm00140a015
3047500 13282 None 0 Rat Functional pKd = 6.8 6.8 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 349 11 2 4 3.6 CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1 10.1021/jm00389a008
CHEMBL1191645 13282 None 0 Rat Functional pKd = 6.8 6.8 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 349 11 2 4 3.6 CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1 10.1021/jm00389a008
CHEMBL542776 13282 None 0 Rat Functional pKd = 6.8 6.8 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 349 11 2 4 3.6 CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1 10.1021/jm00389a008
3047500 13282 None 0 Rat Functional pKd = 6.8 6.8 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 349 11 2 4 3.6 CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1 10.1021/jm00389a008
CHEMBL1191645 13282 None 0 Rat Functional pKd = 6.8 6.8 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 349 11 2 4 3.6 CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1 10.1021/jm00389a008
CHEMBL542776 13282 None 0 Rat Functional pKd = 6.8 6.8 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 349 11 2 4 3.6 CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1 10.1021/jm00389a008
44287622 12005 None 0 Guinea pig Functional pKd = 4.8 4.8 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 258 7 2 4 2.4 CC(C)C(=NOCC(O)CNC(C)(C)C)C(C)C 10.1021/jm00380a001
CHEMBL1183276 12005 None 0 Guinea pig Functional pKd = 4.8 4.8 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 258 7 2 4 2.4 CC(C)C(=NOCC(O)CNC(C)(C)C)C(C)C 10.1021/jm00380a001
CHEMBL288140 12005 None 0 Guinea pig Functional pKd = 4.8 4.8 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 258 7 2 4 2.4 CC(C)C(=NOCC(O)CNC(C)(C)C)C(C)C 10.1021/jm00380a001
10403687 2511 None 2 Guinea pig Functional pKd = 4.8 4.8 - 2
Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig
ChEMBL 319 8 2 2 3.9 CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
1205 2511 None 2 Guinea pig Functional pKd = 4.8 4.8 - 2
Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig
ChEMBL 319 8 2 2 3.9 CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
CHEMBL275035 2511 None 2 Guinea pig Functional pKd = 4.8 4.8 - 2
Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig
ChEMBL 319 8 2 2 3.9 CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
12733301 60430 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 235 4 2 4 1.7 CC(C)NCC(O)C1=COc2ccccc2O1 10.1021/jm00140a015
CHEMBL175010 60430 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 235 4 2 4 1.7 CC(C)NCC(O)C1=COc2ccccc2O1 10.1021/jm00140a015
44371406 11668 None 0 Guinea pig Functional pKd = 6.8 6.8 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 278 9 2 4 2.4 C/C(CCc1ccccc1)=N/OCC(O)CNC(C)C 10.1021/jm00180a007
CHEMBL1181107 11668 None 0 Guinea pig Functional pKd = 6.8 6.8 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 278 9 2 4 2.4 C/C(CCc1ccccc1)=N/OCC(O)CNC(C)C 10.1021/jm00180a007
CHEMBL155714 11668 None 0 Guinea pig Functional pKd = 6.8 6.8 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 278 9 2 4 2.4 C/C(CCc1ccccc1)=N/OCC(O)CNC(C)C 10.1021/jm00180a007
44264144 13283 None 0 Rat Functional pKd = 6.8 6.8 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 385 11 2 6 1.6 CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCCO2)cc1 10.1021/jm00389a008
CHEMBL1191646 13283 None 0 Rat Functional pKd = 6.8 6.8 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 385 11 2 6 1.6 CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCCO2)cc1 10.1021/jm00389a008
CHEMBL542777 13283 None 0 Rat Functional pKd = 6.8 6.8 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 385 11 2 6 1.6 CC(C)NCC(O)COc1ccc(CCS(=O)(=O)CC2CCCO2)cc1 10.1021/jm00389a008
361497 49094 None 0 Guinea pig Functional pKd = 5.8 5.8 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 243 6 2 5 1.3 CC(C)NCC(O)COC(=O)c1cccs1 10.1021/jm00387a006
CHEMBL156147 49094 None 0 Guinea pig Functional pKd = 5.8 5.8 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 243 6 2 5 1.3 CC(C)NCC(O)COC(=O)c1cccs1 10.1021/jm00387a006
172454272 196013 None 0 Human Functional pKd = 5.8 5.8 - 1
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 359 7 2 7 1.6 O[C@@H](CNCC1COc2ccccc2O1)COc1ccc2c(c1)OCO2 10.1016/j.ejmech.2022.114961
CHEMBL5415148 196013 None 0 Human Functional pKd = 5.8 5.8 - 1
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 359 7 2 7 1.6 O[C@@H](CNCC1COc2ccccc2O1)COc1ccc2c(c1)OCO2 10.1016/j.ejmech.2022.114961
12778441 78397 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 338 7 2 4 3.6 CCC(C)(C)NC[C@H](O)CON=C1c2ccccc2-c2ccccc21 10.1021/jm00350a009
CHEMBL2110257 78397 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 338 7 2 4 3.6 CCC(C)(C)NC[C@H](O)CON=C1c2ccccc2-c2ccccc21 10.1021/jm00350a009
3486 3157 None 44 Guinea pig Functional pKd = 5.8 5.8 - 2
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00387a006
4883 3157 None 44 Guinea pig Functional pKd = 5.8 5.8 - 2
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00387a006
555 3157 None 44 Guinea pig Functional pKd = 5.8 5.8 - 2
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00387a006
CHEMBL6995 3157 None 44 Guinea pig Functional pKd = 5.8 5.8 - 2
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00387a006
DB01297 3157 None 44 Guinea pig Functional pKd = 5.8 5.8 - 2
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00387a006
172468087 196633 None 0 Human Functional pKd = 5.8 5.8 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 459 10 2 5 5.0 CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1 10.1016/j.ejmech.2022.114961
CHEMBL5428413 196633 None 0 Human Functional pKd = 5.8 5.8 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 459 10 2 5 5.0 CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1 10.1016/j.ejmech.2022.114961
3486 3157 None 44 Guinea pig Functional pKd = 5.8 5.8 - 2
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00380a001
4883 3157 None 44 Guinea pig Functional pKd = 5.8 5.8 - 2
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00380a001
555 3157 None 44 Guinea pig Functional pKd = 5.8 5.8 - 2
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00380a001
CHEMBL6995 3157 None 44 Guinea pig Functional pKd = 5.8 5.8 - 2
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00380a001
DB01297 3157 None 44 Guinea pig Functional pKd = 5.8 5.8 - 2
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00380a001
12606710 13401 None 0 Guinea pig Functional pKd = 4.8 4.8 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 204 6 3 4 0.7 CC(C)NOCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL1192661 13401 None 0 Guinea pig Functional pKd = 4.8 4.8 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 204 6 3 4 0.7 CC(C)NOCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL543940 13401 None 0 Guinea pig Functional pKd = 4.8 4.8 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 204 6 3 4 0.7 CC(C)NOCC(O)CNC(C)(C)C 10.1021/jm00180a007
44287431 11232 None 0 Guinea pig Functional pKd = 4.8 4.8 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 244 8 2 4 2.0 CC(C)NCC(O)CON=C(C(C)C)C(C)C 10.1021/jm00380a001
CHEMBL1178793 11232 None 0 Guinea pig Functional pKd = 4.8 4.8 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 244 8 2 4 2.0 CC(C)NCC(O)CON=C(C(C)C)C(C)C 10.1021/jm00380a001
CHEMBL41839 11232 None 0 Guinea pig Functional pKd = 4.8 4.8 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 244 8 2 4 2.0 CC(C)NCC(O)CON=C(C(C)C)C(C)C 10.1021/jm00380a001
54757331 65538 None 0 Human Functional pKd = 7.8 7.8 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 883 28 4 10 6.3 C=CCc1ccccc1OCC(O)CNCCOCCOCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1 10.1021/jm2008562
CHEMBL1830619 65538 None 0 Human Functional pKd = 7.8 7.8 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 883 28 4 10 6.3 C=CCc1ccccc1OCC(O)CNCCOCCOCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1 10.1021/jm2008562
155774 4096 None 34 Human Functional pKd = 7.8 7.8 38 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
2848 4096 None 34 Human Functional pKd = 7.8 7.8 38 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
538 4096 None 34 Human Functional pKd = 7.8 7.8 38 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
CHEMBL75753 4096 None 34 Human Functional pKd = 7.8 7.8 38 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
DB13781 4096 None 34 Human Functional pKd = 7.8 7.8 38 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
56598831 89177 None 0 Human Functional pKd = 7.8 7.8 1023 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 459 15 5 7 2.3 O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
CHEMBL2348220 89177 None 0 Human Functional pKd = 7.8 7.8 1023 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 459 15 5 7 2.3 O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
CHEMBL2365796 89177 None 0 Human Functional pKd = 7.8 7.8 1023 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 459 15 5 7 2.3 O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
44264411 13405 None 0 Rat Functional pKd = 7.8 7.8 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 443 15 2 6 3.6 COc1ccc(CCNCC(O)COc2ccc(CCOCC3CCC3)cc2)cc1OC 10.1021/jm00389a008
CHEMBL1192677 13405 None 0 Rat Functional pKd = 7.8 7.8 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 443 15 2 6 3.6 COc1ccc(CCNCC(O)COc2ccc(CCOCC3CCC3)cc2)cc1OC 10.1021/jm00389a008
CHEMBL543957 13405 None 0 Rat Functional pKd = 7.8 7.8 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 443 15 2 6 3.6 COc1ccc(CCNCC(O)COc2ccc(CCOCC3CCC3)cc2)cc1OC 10.1021/jm00389a008
3486 3157 None 44 Guinea pig Functional pKd = 6.8 6.8 - 2
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00140a015
4883 3157 None 44 Guinea pig Functional pKd = 6.8 6.8 - 2
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00140a015
555 3157 None 44 Guinea pig Functional pKd = 6.8 6.8 - 2
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00140a015
CHEMBL6995 3157 None 44 Guinea pig Functional pKd = 6.8 6.8 - 2
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00140a015
DB01297 3157 None 44 Guinea pig Functional pKd = 6.8 6.8 - 2
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1021/jm00140a015
172450718 196107 None 0 Human Functional pKd = 5.8 5.8 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 426 9 3 6 3.0 CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc3c(c2)OC(C)(C)CC3=O)cc1 10.1016/j.ejmech.2022.114961
CHEMBL5416996 196107 None 0 Human Functional pKd = 5.8 5.8 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 426 9 3 6 3.0 CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc3c(c2)OC(C)(C)CC3=O)cc1 10.1016/j.ejmech.2022.114961
137 370 None 37 Human Functional pKd = 6.8 6.8 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
2119 370 None 37 Human Functional pKd = 6.8 6.8 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
563 370 None 37 Human Functional pKd = 6.8 6.8 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
66368 370 None 37 Human Functional pKd = 6.8 6.8 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
CHEMBL266195 370 None 37 Human Functional pKd = 6.8 6.8 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
DB00866 370 None 37 Human Functional pKd = 6.8 6.8 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
54756927 65508 None 0 Human Functional pKd = 6.7 6.7 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 833 22 4 8 7.5 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNC[C@H](O)COc1cccc2ccccc12 10.1021/jm2008562
CHEMBL1830486 65508 None 0 Human Functional pKd = 6.7 6.7 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 833 22 4 8 7.5 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNC[C@H](O)COc1cccc2ccccc12 10.1021/jm2008562
12606701 11231 None 0 Guinea pig Functional pKd = 5.7 5.7 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 228 6 2 4 1.7 CC(C)NCC(O)CON=C1CCCCC1 10.1021/jm00180a007
CHEMBL1178787 11231 None 0 Guinea pig Functional pKd = 5.7 5.7 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 228 6 2 4 1.7 CC(C)NCC(O)CON=C1CCCCC1 10.1021/jm00180a007
CHEMBL41378 11231 None 0 Guinea pig Functional pKd = 5.7 5.7 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 228 6 2 4 1.7 CC(C)NCC(O)CON=C1CCCCC1 10.1021/jm00180a007
44371426 14312 None 0 Guinea pig Functional pKd = 6.7 6.7 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 216 6 2 4 1.5 CC/C(C)=N\OCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL1161384 14312 None 0 Guinea pig Functional pKd = 6.7 6.7 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 216 6 2 4 1.5 CC/C(C)=N\OCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL1199902 14312 None 0 Guinea pig Functional pKd = 6.7 6.7 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 216 6 2 4 1.5 CC/C(C)=N\OCC(O)CNC(C)(C)C 10.1021/jm00180a007
2303 3187 None 44 Human Functional pKd = 6.7 6.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
4946 3187 None 44 Human Functional pKd = 6.7 6.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
564 3187 None 44 Human Functional pKd = 6.7 6.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
63 3187 None 44 Human Functional pKd = 6.7 6.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
91536 3187 None 44 Human Functional pKd = 6.7 6.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
CHEMBL27 3187 None 44 Human Functional pKd = 6.7 6.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
CHEMBL452861 3187 None 44 Human Functional pKd = 6.7 6.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
DB00571 3187 None 44 Human Functional pKd = 6.7 6.7 -6 20
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm2008562
11768868 13166 None 1 Guinea pig Functional pKd = 4.7 4.7 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 161 4 2 3 0.4 COCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL1190805 13166 None 1 Guinea pig Functional pKd = 4.7 4.7 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 161 4 2 3 0.4 COCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL541607 13166 None 1 Guinea pig Functional pKd = 4.7 4.7 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 161 4 2 3 0.4 COCC(O)CNC(C)(C)C 10.1021/jm00180a007
12606701 11231 None 0 Guinea pig Functional pKd = 4.7 4.7 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 228 6 2 4 1.7 CC(C)NCC(O)CON=C1CCCCC1 10.1021/jm00380a001
CHEMBL1178787 11231 None 0 Guinea pig Functional pKd = 4.7 4.7 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 228 6 2 4 1.7 CC(C)NCC(O)CON=C1CCCCC1 10.1021/jm00380a001
CHEMBL41378 11231 None 0 Guinea pig Functional pKd = 4.7 4.7 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 228 6 2 4 1.7 CC(C)NCC(O)CON=C1CCCCC1 10.1021/jm00380a001
2303 3187 None 44 Guinea pig Functional pKd = 8.6 8.6 -21 20
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00180a007
4946 3187 None 44 Guinea pig Functional pKd = 8.6 8.6 -21 20
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00180a007
564 3187 None 44 Guinea pig Functional pKd = 8.6 8.6 -21 20
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00180a007
63 3187 None 44 Guinea pig Functional pKd = 8.6 8.6 -21 20
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00180a007
91536 3187 None 44 Guinea pig Functional pKd = 8.6 8.6 -21 20
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00180a007
CHEMBL27 3187 None 44 Guinea pig Functional pKd = 8.6 8.6 -21 20
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00180a007
CHEMBL452861 3187 None 44 Guinea pig Functional pKd = 8.6 8.6 -21 20
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00180a007
DB00571 3187 None 44 Guinea pig Functional pKd = 8.6 8.6 -21 20
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00180a007
2176 3127 None 40 Human Functional pKd = 8.6 8.6 1 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1021/jm2008562
4828 3127 None 40 Human Functional pKd = 8.6 8.6 1 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1021/jm2008562
4828.0 3127 None 40 Human Functional pKd = 8.6 8.6 1 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1021/jm2008562
91 3127 None 40 Human Functional pKd = 8.6 8.6 1 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1021/jm2008562
CHEMBL500 3127 None 40 Human Functional pKd = 8.6 8.6 1 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1021/jm2008562
DB00960 3127 None 40 Human Functional pKd = 8.6 8.6 1 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1021/jm2008562
2303 3187 None 44 Rat Functional pKd = 8.6 8.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
4946 3187 None 44 Rat Functional pKd = 8.6 8.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
564 3187 None 44 Rat Functional pKd = 8.6 8.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
63 3187 None 44 Rat Functional pKd = 8.6 8.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
91536 3187 None 44 Rat Functional pKd = 8.6 8.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
CHEMBL27 3187 None 44 Rat Functional pKd = 8.6 8.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
CHEMBL452861 3187 None 44 Rat Functional pKd = 8.6 8.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
DB00571 3187 None 44 Rat Functional pKd = 8.6 8.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
56597179 88303 None 0 Human Functional pKd = 8.6 8.6 2754 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 473 14 5 7 2.9 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
CHEMBL2348219 88303 None 0 Human Functional pKd = 8.6 8.6 2754 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 473 14 5 7 2.9 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccc(O)cc1 10.1021/jm400348g
2369 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
2369.0 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
356 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
549 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
CHEMBL423 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
DB00195 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
44264404 13429 None 0 Rat Functional pKd = 8.5 8.5 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 319 11 2 4 2.5 OC(CNC1CC1)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL1192875 13429 None 0 Rat Functional pKd = 8.5 8.5 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 319 11 2 4 2.5 OC(CNC1CC1)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL544190 13429 None 0 Rat Functional pKd = 8.5 8.5 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 319 11 2 4 2.5 OC(CNC1CC1)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
2369 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
2369.0 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
356 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
549 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
CHEMBL423 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
DB00195 622 None 46 Rat Functional pKd = 8.5 8.5 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
44287522 11228 None 0 Guinea pig Functional pKd = 4.7 4.7 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 244 10 2 4 2.3 CCCC(CCC)=NOCC(O)CNC(C)C 10.1021/jm00380a001
CHEMBL1178778 11228 None 0 Guinea pig Functional pKd = 4.7 4.7 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 244 10 2 4 2.3 CCCC(CCC)=NOCC(O)CNC(C)C 10.1021/jm00380a001
CHEMBL40783 11228 None 0 Guinea pig Functional pKd = 4.7 4.7 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 244 10 2 4 2.3 CCCC(CCC)=NOCC(O)CNC(C)C 10.1021/jm00380a001
54757027 65512 None 0 Human Functional pKd = 6.7 6.7 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 889 26 4 8 9.1 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCCCCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
CHEMBL1830490 65512 None 0 Human Functional pKd = 6.7 6.7 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 889 26 4 8 9.1 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCCCCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
1786 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
4171 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
4171.0 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
553 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
CHEMBL13 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
DB00264 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
1786 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
4171 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
4171.0 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
553 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
CHEMBL13 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
DB00264 2520 None 51 Rat Functional pKd = 7.6 7.6 - 7
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1021/jm00389a008
172462381 196770 None 0 Human Functional pKd = 5.6 5.6 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 383 9 2 5 3.4 CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCCc3ccccc3)cc2O1 10.1016/j.ejmech.2022.114961
CHEMBL5431834 196770 None 0 Human Functional pKd = 5.6 5.6 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 383 9 2 5 3.4 CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCCc3ccccc3)cc2O1 10.1016/j.ejmech.2022.114961
54757026 65511 None 0 Human Functional pKd = 6.6 6.6 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 833 22 4 8 7.5 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
CHEMBL1830489 65511 None 0 Human Functional pKd = 6.6 6.6 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 833 22 4 8 7.5 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
172455562 196362 None 0 Human Functional pKd = 5.6 5.6 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 383 7 2 7 2.0 O=c1ccc2ccc(OC[C@@H](O)CNCC3COc4ccccc4O3)cc2o1 10.1016/j.ejmech.2022.114961
CHEMBL5422259 196362 None 0 Human Functional pKd = 5.6 5.6 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 383 7 2 7 2.0 O=c1ccc2ccc(OC[C@@H](O)CNCC3COc4ccccc4O3)cc2o1 10.1016/j.ejmech.2022.114961
44287498 12407 None 0 Guinea pig Functional pKd = 4.6 4.6 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 214 6 2 4 1.3 CC(C)NCC(O)CON=C1CCCC1 10.1021/jm00380a001
CHEMBL1185760 12407 None 0 Guinea pig Functional pKd = 4.6 4.6 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 214 6 2 4 1.3 CC(C)NCC(O)CON=C1CCCC1 10.1021/jm00380a001
CHEMBL431713 12407 None 0 Guinea pig Functional pKd = 4.6 4.6 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 214 6 2 4 1.3 CC(C)NCC(O)CON=C1CCCC1 10.1021/jm00380a001
127940 207342 None 5 Human Functional pKd = 6.6 6.6 - 0
The compound was evaluated for the antagonistic activity against alpha-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against alpha-1 adrenergic receptor.
ChEMBL 351 8 4 3 2.9 CC(CCc1ccccc1)NCC(O)c1cc(C(N)=O)c2[nH]ccc2c1 10.1021/jm00156a019
CHEMBL7585 207342 None 5 Human Functional pKd = 6.6 6.6 - 0
The compound was evaluated for the antagonistic activity against alpha-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against alpha-1 adrenergic receptor.
ChEMBL 351 8 4 3 2.9 CC(CCc1ccccc1)NCC(O)c1cc(C(N)=O)c2[nH]ccc2c1 10.1021/jm00156a019
172462257 196705 None 0 Human Functional pKd = 6.6 6.6 -2 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 459 10 2 5 5.0 CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1 10.1016/j.ejmech.2022.114961
CHEMBL5430355 196705 None 0 Human Functional pKd = 6.6 6.6 -2 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 459 10 2 5 5.0 CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCC(c3ccccc3)c3ccccc3)cc2O1 10.1016/j.ejmech.2022.114961
56598833 88301 None 0 Human Functional pKd = 7.6 7.6 436 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 433 14 5 7 2.0 CCOCCOc1ccc(OCC(O)CNCCNC(=O)Nc2ccc(O)cc2)cc1 10.1021/jm400348g
CHEMBL2348217 88301 None 0 Human Functional pKd = 7.6 7.6 436 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 433 14 5 7 2.0 CCOCCOc1ccc(OCC(O)CNCCNC(=O)Nc2ccc(O)cc2)cc1 10.1021/jm400348g
168613 60341 None 17 Guinea pig Functional pKd = 7.6 7.6 - 0
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 316 6 2 8 0.5 CC(C)(C)NC[C@@H](O)COc1nsnc1N1CCOCC1 10.1021/jm00350a009
CHEMBL1744069 60341 None 17 Guinea pig Functional pKd = 7.6 7.6 - 0
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 316 6 2 8 0.5 CC(C)(C)NC[C@@H](O)COc1nsnc1N1CCOCC1 10.1021/jm00350a009
12733306 60101 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 368 5 1 6 2.5 COc1ccccc1N1CCN(CC(O)C2=COc3ccccc3O2)CC1 10.1021/jm00140a015
CHEMBL173882 60101 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaAntagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria
ChEMBL 368 5 1 6 2.5 COc1ccccc1N1CCN(CC(O)C2=COc3ccccc3O2)CC1 10.1021/jm00140a015
2303 3187 None 44 Rat Functional pKd = 5.6 5.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
4946 3187 None 44 Rat Functional pKd = 5.6 5.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
564 3187 None 44 Rat Functional pKd = 5.6 5.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
63 3187 None 44 Rat Functional pKd = 5.6 5.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
91536 3187 None 44 Rat Functional pKd = 5.6 5.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
CHEMBL27 3187 None 44 Rat Functional pKd = 5.6 5.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
CHEMBL452861 3187 None 44 Rat Functional pKd = 5.6 5.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
DB00571 3187 None 44 Rat Functional pKd = 5.6 5.6 - 20
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm970338c
10042467 1426 None 1 Guinea pig Functional pKd = 4.6 4.6 - 2
Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig
ChEMBL 333 8 1 2 4.3 CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C 10.1021/jm991056a
1203 1426 None 1 Guinea pig Functional pKd = 4.6 4.6 - 2
Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig
ChEMBL 333 8 1 2 4.3 CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C 10.1021/jm991056a
CHEMBL11553 1426 None 1 Guinea pig Functional pKd = 4.6 4.6 - 2
Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig
ChEMBL 333 8 1 2 4.3 CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C 10.1021/jm991056a
44371642 49232 None 0 Guinea pig Functional pKd = 4.6 4.6 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 203 6 2 4 0.5 CC(C)NCC(O)COC(=O)C(C)C 10.1021/jm00387a006
CHEMBL156271 49232 None 0 Guinea pig Functional pKd = 4.6 4.6 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 203 6 2 4 0.5 CC(C)NCC(O)COC(=O)C(C)C 10.1021/jm00387a006
12606702 12017 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 242 5 2 4 2.1 CC(C)(C)NCC(O)CON=C1CCCCC1 10.1021/jm00180a007
CHEMBL1161383 12017 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 242 5 2 4 2.1 CC(C)(C)NCC(O)CON=C1CCCCC1 10.1021/jm00180a007
CHEMBL1183312 12017 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 242 5 2 4 2.1 CC(C)(C)NCC(O)CON=C1CCCCC1 10.1021/jm00180a007
CHEMBL289868 12017 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 242 5 2 4 2.1 CC(C)(C)NCC(O)CON=C1CCCCC1 10.1021/jm00180a007
12606704 14321 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 290 7 2 4 2.8 CC(/C=C/c1ccccc1)=N\OCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL1161386 14321 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 290 7 2 4 2.8 CC(/C=C/c1ccccc1)=N\OCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL1199951 14321 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 290 7 2 4 2.8 CC(/C=C/c1ccccc1)=N\OCC(O)CNC(C)(C)C 10.1021/jm00180a007
44371312 49272 None 0 Guinea pig Functional pKd = 4.6 4.6 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 203 5 2 4 0.7 CCC(=O)OCC(O)CNC(C)(C)C 10.1021/jm00387a006
CHEMBL156304 49272 None 0 Guinea pig Functional pKd = 4.6 4.6 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 203 5 2 4 0.7 CCC(=O)OCC(O)CNC(C)(C)C 10.1021/jm00387a006
44264509 206146 None 0 Rat Functional pKd = 5.5 5.5 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 429 14 2 4 4.5 CC(CCc1ccc(F)cc1)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL6749 206146 None 0 Rat Functional pKd = 5.5 5.5 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 429 14 2 4 4.5 CC(CCc1ccc(F)cc1)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
3047492 206424 None 5 Guinea pig Functional pKd = 5.5 5.5 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 293 10 2 4 2.4 CC(C)NCC(O)COc1ccc(COCC2CC2)cc1 10.1021/jm00389a008
CHEMBL6939 206424 None 5 Guinea pig Functional pKd = 5.5 5.5 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 293 10 2 4 2.4 CC(C)NCC(O)COc1ccc(COCC2CC2)cc1 10.1021/jm00389a008
2303 3187 None 44 Guinea pig Functional pKd = 8.5 8.5 -21 20
Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00373a008
4946 3187 None 44 Guinea pig Functional pKd = 8.5 8.5 -21 20
Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00373a008
564 3187 None 44 Guinea pig Functional pKd = 8.5 8.5 -21 20
Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00373a008
63 3187 None 44 Guinea pig Functional pKd = 8.5 8.5 -21 20
Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00373a008
91536 3187 None 44 Guinea pig Functional pKd = 8.5 8.5 -21 20
Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00373a008
CHEMBL27 3187 None 44 Guinea pig Functional pKd = 8.5 8.5 -21 20
Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00373a008
CHEMBL452861 3187 None 44 Guinea pig Functional pKd = 8.5 8.5 -21 20
Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00373a008
DB00571 3187 None 44 Guinea pig Functional pKd = 8.5 8.5 -21 20
Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00373a008
54669764 65513 None 0 Human Functional pKd = 8.5 8.5 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 893 26 4 10 6.8 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNC[C@H](O)COc1cccc2ccccc12 10.1021/jm2008562
CHEMBL1830491 65513 None 0 Human Functional pKd = 8.5 8.5 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 893 26 4 10 6.8 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNC[C@H](O)COc1cccc2ccccc12 10.1021/jm2008562
56598967 88295 None 0 Human Functional pKd = 8.5 8.5 2238 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 457 14 4 6 3.2 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccccc1 10.1021/jm400348g
CHEMBL2348211 88295 None 0 Human Functional pKd = 8.5 8.5 2238 3
Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrsAntagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs
ChEMBL 457 14 4 6 3.2 O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccccc1 10.1021/jm400348g
54757026 65511 None 0 Human Functional pKd = 7.5 7.5 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 833 22 4 8 7.5 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
CHEMBL1830489 65511 None 0 Human Functional pKd = 7.5 7.5 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 833 22 4 8 7.5 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
54758320 65539 None 0 Human Functional pKd = 6.5 6.5 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 794 20 5 8 6.1 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCNCC(O)COc1cccc2[nH]ccc12 10.1021/jm2008562
CHEMBL1830620 65539 None 0 Human Functional pKd = 6.5 6.5 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 794 20 5 8 6.1 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCNCC(O)COc1cccc2[nH]ccc12 10.1021/jm2008562
12606706 93286 None 0 Guinea pig Functional pKd = 6.5 6.5 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 202 5 2 4 1.1 CC(C)=NOCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL24480 93286 None 0 Guinea pig Functional pKd = 6.5 6.5 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 202 5 2 4 1.1 CC(C)=NOCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL555848 93286 None 0 Guinea pig Functional pKd = 6.5 6.5 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 202 5 2 4 1.1 CC(C)=NOCC(O)CNC(C)(C)C 10.1021/jm00180a007
172445308 195059 None 0 Human Functional pKd = 5.5 5.5 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 413 8 2 7 2.7 CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCc3ccc4c(c3)OCO4)cc2O1 10.1016/j.ejmech.2022.114961
CHEMBL5395772 195059 None 0 Human Functional pKd = 5.5 5.5 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 413 8 2 7 2.7 CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCCc3ccc4c(c3)OCO4)cc2O1 10.1016/j.ejmech.2022.114961
1531 2266 None 40 Guinea pig Functional pKd = 7.5 7.5 - 12
The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 10.1021/jm00156a019
3869 2266 None 40 Guinea pig Functional pKd = 7.5 7.5 - 12
The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 10.1021/jm00156a019
3869.0 2266 None 40 Guinea pig Functional pKd = 7.5 7.5 - 12
The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 10.1021/jm00156a019
7207 2266 None 40 Guinea pig Functional pKd = 7.5 7.5 - 12
The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 10.1021/jm00156a019
CHEMBL429 2266 None 40 Guinea pig Functional pKd = 7.5 7.5 - 12
The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 10.1021/jm00156a019
DB00598 2266 None 40 Guinea pig Functional pKd = 7.5 7.5 - 12
The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor.
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 10.1021/jm00156a019
172461924 196811 None 0 Human Functional pKd = 5.5 5.5 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 413 7 2 7 2.6 CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCC3COc4ccccc4O3)cc2O1 10.1016/j.ejmech.2022.114961
CHEMBL5432691 196811 None 0 Human Functional pKd = 5.5 5.5 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 413 7 2 7 2.6 CC1(C)CC(=O)c2ccc(OC[C@H](O)CNCC3COc4ccccc4O3)cc2O1 10.1016/j.ejmech.2022.114961
172470154 197049 None 0 Human Functional pKd = 5.5 5.5 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 396 9 3 6 2.3 CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc3ccc(=O)oc3c2)cc1 10.1016/j.ejmech.2022.114961
CHEMBL5437540 197049 None 0 Human Functional pKd = 5.5 5.5 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 396 9 3 6 2.3 CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccc3ccc(=O)oc3c2)cc1 10.1016/j.ejmech.2022.114961
121848 130778 None 3 Guinea pig Functional pKd = 7.5 7.5 - 2
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 324 5 2 4 3.2 CC(C)(C)NCC(O)CON=C1c2ccccc2-c2ccccc21 10.1021/jm00350a009
CHEMBL368457 130778 None 3 Guinea pig Functional pKd = 7.5 7.5 - 2
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 324 5 2 4 3.2 CC(C)(C)NCC(O)CON=C1c2ccccc2-c2ccccc21 10.1021/jm00350a009
10028830 2246 None 31 Human Functional pKd = 6.5 6.5 -186 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 497 13 4 6 2.7 O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1 10.1016/j.ejmech.2022.114961
3932 2246 None 31 Human Functional pKd = 6.5 6.5 -186 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 497 13 4 6 2.7 O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1 10.1016/j.ejmech.2022.114961
CHEMBL4238084 2246 None 31 Human Functional pKd = 6.5 6.5 -186 3
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 497 13 4 6 2.7 O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1 10.1016/j.ejmech.2022.114961
44264298 13379 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 346 12 2 5 2.7 CC(CC#N)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL1192477 13379 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 346 12 2 5 2.7 CC(CC#N)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL543717 13379 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 346 12 2 5 2.7 CC(CC#N)NCC(O)COc1ccc(CCOCC2CCC2)cc1 10.1021/jm00389a008
12778440 60192 None 0 Guinea pig Functional pKd = 7.5 7.5 - 0
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 338 7 2 4 3.6 CCC(C)(C)NCC(O)CON=C1c2ccccc2-c2ccccc21 10.1021/jm00350a009
CHEMBL173976 60192 None 0 Guinea pig Functional pKd = 7.5 7.5 - 0
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 338 7 2 4 3.6 CCC(C)(C)NCC(O)CON=C1c2ccccc2-c2ccccc21 10.1021/jm00350a009
54756929 65510 None 0 Human Functional pKd = 6.5 6.5 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 805 20 4 8 6.7 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
CHEMBL1830488 65510 None 0 Human Functional pKd = 6.5 6.5 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 805 20 4 8 6.7 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
44263933 13662 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 10 2 4 2.7 CC(C)NCC(O)COc1ccc(COCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL1194583 13662 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 10 2 4 2.7 CC(C)NCC(O)COc1ccc(COCC2CCC2)cc1 10.1021/jm00389a008
CHEMBL552898 13662 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 307 10 2 4 2.7 CC(C)NCC(O)COc1ccc(COCC2CCC2)cc1 10.1021/jm00389a008
172455968 196414 None 0 Human Functional pKd = 5.4 5.4 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 371 7 2 7 1.4 O=C1COc2cc(OC[C@@H](O)CNCC3COc4ccccc4O3)ccc21 10.1016/j.ejmech.2022.114961
CHEMBL5423415 196414 None 0 Human Functional pKd = 5.4 5.4 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 371 7 2 7 1.4 O=C1COc2cc(OC[C@@H](O)CNCC3COc4ccccc4O3)ccc21 10.1016/j.ejmech.2022.114961
172461561 196828 None 0 Human Functional pKd = 5.4 5.4 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 413 7 2 7 2.6 CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCC3COc4ccccc4O3)cc2O1 10.1016/j.ejmech.2022.114961
CHEMBL5432967 196828 None 0 Human Functional pKd = 5.4 5.4 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 413 7 2 7 2.6 CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCC3COc4ccccc4O3)cc2O1 10.1016/j.ejmech.2022.114961
5311452 3671 None 7 Human Functional pKd = 7.4 7.4 -5 4
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 325 7 2 3 3.7 CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O 10.1016/j.ejmech.2022.114961
547 3671 None 7 Human Functional pKd = 7.4 7.4 -5 4
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 325 7 2 3 3.7 CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O 10.1016/j.ejmech.2022.114961
CHEMBL1326499 3671 None 7 Human Functional pKd = 7.4 7.4 -5 4
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 325 7 2 3 3.7 CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O 10.1016/j.ejmech.2022.114961
2447484 102823 None 0 Guinea pig Functional pKd = 7.4 7.4 - 2
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 324 5 2 4 3.2 CC(C)(C)NC[C@H](O)CON=C1c2ccccc2-c2ccccc21 10.1021/jm00350a009
CHEMBL305153 102823 None 0 Guinea pig Functional pKd = 7.4 7.4 - 2
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atriaCompound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
ChEMBL 324 5 2 4 3.2 CC(C)(C)NC[C@H](O)CON=C1c2ccccc2-c2ccccc21 10.1021/jm00350a009
54758415 65540 None 0 Human Functional pKd = 7.4 7.4 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 882 26 5 10 6.1 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2[nH]ccc12 10.1021/jm2008562
CHEMBL1830621 65540 None 0 Human Functional pKd = 7.4 7.4 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 882 26 5 10 6.1 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2[nH]ccc12 10.1021/jm2008562
12606709 14348 None 0 Guinea pig Functional pKd = 5.4 5.4 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 296 5 2 4 3.0 CC(C)(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C 10.1021/jm00180a007
CHEMBL1161382 14348 None 0 Guinea pig Functional pKd = 5.4 5.4 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 296 5 2 4 3.0 CC(C)(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C 10.1021/jm00180a007
CHEMBL1200073 14348 None 0 Guinea pig Functional pKd = 5.4 5.4 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 296 5 2 4 3.0 CC(C)(C)NCC(O)CO/N=C1\CC2CCC1(C)C2(C)C 10.1021/jm00180a007
3047500 13282 None 0 Guinea pig Functional pKd = 5.4 5.4 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 349 11 2 4 3.6 CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1 10.1021/jm00389a008
CHEMBL1191645 13282 None 0 Guinea pig Functional pKd = 5.4 5.4 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 349 11 2 4 3.6 CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1 10.1021/jm00389a008
CHEMBL542776 13282 None 0 Guinea pig Functional pKd = 5.4 5.4 - 0
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 349 11 2 4 3.6 CC(C)NCC(O)COc1ccc(CCOCC2CCCCC2)cc1 10.1021/jm00389a008
44371514 11705 None 0 Guinea pig Functional pKd = 6.4 6.4 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 216 8 2 4 1.5 CCC/C(C)=N\OCC(O)CNC(C)C 10.1021/jm00180a007
CHEMBL1181235 11705 None 0 Guinea pig Functional pKd = 6.4 6.4 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 216 8 2 4 1.5 CCC/C(C)=N\OCC(O)CNC(C)C 10.1021/jm00180a007
CHEMBL160282 11705 None 0 Guinea pig Functional pKd = 6.4 6.4 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 216 8 2 4 1.5 CCC/C(C)=N\OCC(O)CNC(C)C 10.1021/jm00180a007
172465355 196533 None 0 Human Functional pKd = 5.4 5.4 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 383 9 2 5 3.4 CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCCc3ccccc3)cc2O1 10.1016/j.ejmech.2022.114961
CHEMBL5426087 196533 None 0 Human Functional pKd = 5.4 5.4 - 0
Antagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubationAntagonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as inhibition of fenoterol-induced CRE-SPAP production by measuring rightward shift of the fenoterol concentration response curve measured after 5 hrs incubation
ChEMBL 383 9 2 5 3.4 CC1(C)CC(=O)c2ccc(OC[C@@H](O)CNCCCc3ccccc3)cc2O1 10.1016/j.ejmech.2022.114961
127940 207342 None 5 Guinea pig Functional pKd = 7.4 7.4 - 0
The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptorThe compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor
ChEMBL 351 8 4 3 2.9 CC(CCc1ccccc1)NCC(O)c1cc(C(N)=O)c2[nH]ccc2c1 10.1021/jm00156a019
CHEMBL7585 207342 None 5 Guinea pig Functional pKd = 7.4 7.4 - 0
The compound was evaluated for the antagonistic activity against beta-1 adrenergic receptorThe compound was evaluated for the antagonistic activity against beta-1 adrenergic receptor
ChEMBL 351 8 4 3 2.9 CC(CCc1ccccc1)NCC(O)c1cc(C(N)=O)c2[nH]ccc2c1 10.1021/jm00156a019
2369 622 None 46 Guinea pig Functional pKd = 5.4 5.4 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
2369.0 622 None 46 Guinea pig Functional pKd = 5.4 5.4 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
356 622 None 46 Guinea pig Functional pKd = 5.4 5.4 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
549 622 None 46 Guinea pig Functional pKd = 5.4 5.4 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
CHEMBL423 622 None 46 Guinea pig Functional pKd = 5.4 5.4 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
DB00195 622 None 46 Guinea pig Functional pKd = 5.4 5.4 - 3
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea
ChEMBL 307 11 2 4 2.4 OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C 10.1021/jm00389a008
137 370 None 37 Human Functional pKd = 8.4 8.4 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
2119 370 None 37 Human Functional pKd = 8.4 8.4 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
563 370 None 37 Human Functional pKd = 8.4 8.4 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
66368 370 None 37 Human Functional pKd = 8.4 8.4 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
CHEMBL266195 370 None 37 Human Functional pKd = 8.4 8.4 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
DB00866 370 None 37 Human Functional pKd = 8.4 8.4 -3 8
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1021/jm2008562
2303 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
4946 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
564 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
63 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
91536 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
CHEMBL27 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
CHEMBL452861 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
DB00571 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
2303 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
4946 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
564 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
63 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
91536 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
CHEMBL27 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
CHEMBL452861 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
DB00571 3187 None 44 Rat Functional pKd = 8.4 8.4 - 20
Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaCardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1021/jm00389a008
54757232 65537 None 0 Human Functional pKd = 7.4 7.4 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 883 28 4 10 6.3 C=CCc1ccccc1OC[C@@H](O)CNCCOCCOCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1 10.1021/jm2008562
CHEMBL1830618 65537 None 0 Human Functional pKd = 7.4 7.4 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 883 28 4 10 6.3 C=CCc1ccccc1OC[C@@H](O)CNCCOCCOCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1 10.1021/jm2008562
54757126 65514 None 0 Human Functional pKd = 7.4 7.4 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 893 26 4 10 6.8 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
CHEMBL1830492 65514 None 0 Human Functional pKd = 7.4 7.4 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 893 26 4 10 6.8 O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCOCCOCCNCC(O)COc1cccc2ccccc12 10.1021/jm2008562
44264188 206368 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 325 10 2 4 2.1 CC(C)NCC(O)COc1ccc(C[S+]([O-])CC2CC2)cc1 10.1021/jm00389a008
CHEMBL6902 206368 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaAntagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria
ChEMBL 325 10 2 4 2.1 CC(C)NCC(O)COc1ccc(C[S+]([O-])CC2CC2)cc1 10.1021/jm00389a008
54757229 65536 None 0 Human Functional pKd = 7.4 7.4 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 795 22 4 8 6.3 C=CCc1ccccc1OCC(O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1 10.1021/jm2008562
CHEMBL1830617 65536 None 0 Human Functional pKd = 7.4 7.4 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 795 22 4 8 6.3 C=CCc1ccccc1OCC(O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1 10.1021/jm2008562
12606687 12225 None 0 Guinea pig Functional pKd = 5.4 5.4 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 175 6 2 3 0.8 CC(C)NCC(O)COC(C)C 10.1021/jm00180a007
CHEMBL1184385 12225 None 0 Guinea pig Functional pKd = 5.4 5.4 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 175 6 2 3 0.8 CC(C)NCC(O)COC(C)C 10.1021/jm00180a007
CHEMBL346972 12225 None 0 Guinea pig Functional pKd = 5.4 5.4 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 175 6 2 3 0.8 CC(C)NCC(O)COC(C)C 10.1021/jm00180a007
134495 749 None 18 Guinea pig Functional pKd = 4.4 4.4 - 2
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 267 5 2 4 2.5 COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC 10.1021/jm00387a006
18026 749 None 18 Guinea pig Functional pKd = 4.4 4.4 - 2
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 267 5 2 4 2.5 COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC 10.1021/jm00387a006
9809 749 None 18 Guinea pig Functional pKd = 4.4 4.4 - 2
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 267 5 2 4 2.5 COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC 10.1021/jm00387a006
CHEMBL289093 749 None 18 Guinea pig Functional pKd = 4.4 4.4 - 2
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 267 5 2 4 2.5 COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC 10.1021/jm00387a006
134495 749 None 18 Guinea pig Functional pKd = 4.4 4.4 - 2
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 267 5 2 4 2.5 COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC 10.1021/jm00380a001
18026 749 None 18 Guinea pig Functional pKd = 4.4 4.4 - 2
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 267 5 2 4 2.5 COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC 10.1021/jm00380a001
9809 749 None 18 Guinea pig Functional pKd = 4.4 4.4 - 2
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 267 5 2 4 2.5 COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC 10.1021/jm00380a001
CHEMBL289093 749 None 18 Guinea pig Functional pKd = 4.4 4.4 - 2
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 267 5 2 4 2.5 COc1ccc(cc1C(C(NC(C)(C)C)C)O)OC 10.1021/jm00380a001
44371383 49628 None 1 Guinea pig Functional pKd = 6.3 6.3 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 257 5 2 5 1.7 CC(C)(C)NCC(O)COC(=O)c1cccs1 10.1021/jm00387a006
CHEMBL156603 49628 None 1 Guinea pig Functional pKd = 6.3 6.3 - 0
Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaAntagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria
ChEMBL 257 5 2 5 1.7 CC(C)(C)NCC(O)COC(=O)c1cccs1 10.1021/jm00387a006
10447834 1933 None 1 Guinea pig Functional pKd = 4.3 4.3 - 3
Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig
ChEMBL 305 7 2 2 3.7 NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
4026 1933 None 1 Guinea pig Functional pKd = 4.3 4.3 - 3
Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig
ChEMBL 305 7 2 2 3.7 NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
CHEMBL275507 1933 None 1 Guinea pig Functional pKd = 4.3 4.3 - 3
Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pigCompound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig
ChEMBL 305 7 2 2 3.7 NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
54757129 65515 None 0 Human Functional pKd = 7.3 7.3 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 795 22 4 8 6.3 C=CCc1ccccc1OC[C@@H](O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1 10.1021/jm2008562
CHEMBL1830493 65515 None 0 Human Functional pKd = 7.3 7.3 - 0
Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysisAntagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis
ChEMBL 795 22 4 8 6.3 C=CCc1ccccc1OC[C@@H](O)CNCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1 10.1021/jm2008562
44287469 12001 None 0 Guinea pig Functional pKd = 5.3 5.3 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 258 9 2 4 2.7 CCCC(CCC)=NOCC(O)CNC(C)(C)C 10.1021/jm00380a001
CHEMBL1183268 12001 None 0 Guinea pig Functional pKd = 5.3 5.3 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 258 9 2 4 2.7 CCCC(CCC)=NOCC(O)CNC(C)(C)C 10.1021/jm00380a001
CHEMBL287766 12001 None 0 Guinea pig Functional pKd = 5.3 5.3 - 0
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaAntagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
ChEMBL 258 9 2 4 2.7 CCCC(CCC)=NOCC(O)CNC(C)(C)C 10.1021/jm00380a001
44288489 169006 None 0 Rat Functional pKd = 7.3 7.3 - 0
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 314 8 3 5 2.5 OC(CNc1nc2ccccc2[nH]1)CON=C(C1CC1)C1CC1 10.1021/jm970338c
CHEMBL43850 169006 None 0 Rat Functional pKd = 7.3 7.3 - 0
Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer)
ChEMBL 314 8 3 5 2.5 OC(CNc1nc2ccccc2[nH]1)CON=C(C1CC1)C1CC1 10.1021/jm970338c
12606684 96127 None 0 Guinea pig Functional pKd = 6.3 6.3 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 203 6 2 3 1.4 CC(C)COCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL1161388 96127 None 0 Guinea pig Functional pKd = 6.3 6.3 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 203 6 2 3 1.4 CC(C)COCC(O)CNC(C)(C)C 10.1021/jm00180a007
CHEMBL26003 96127 None 0 Guinea pig Functional pKd = 6.3 6.3 - 0
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigAntagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig
ChEMBL 203 6 2 3 1.4 CC(C)COCC(O)CNC(C)(C)C 10.1021/jm00180a007
60657 14492 None 24 Rat Functional